04-07-2019 дата публикации
Номер: US20190202864A1
A cyclic peptide is represented by Formula (I), 1. A cyclic peptide represented by Formula (I) ,{'br': None, 'sup': N', 'a', '1', '2', '3', 'b', 'C, 'sub': g', 'i', 'm', 'n', 'j', 'k', 'h, 'R—X—[X—X—X—X—X—X—X—X—X]—X—R\u2003\u2003(I)'}in Formula (I),{'sup': 'N', 'Rrepresents an N-terminal group;'}{'sup': 'C', 'Rrepresents a C-terminal group;'}{'sup': '1', 'Xrepresents an L-leucine residue, an L-isoleucine residue, an L-methionine residue, an L-lysine residue, or an L-arginine residue;'}{'sup': '2', 'Xrepresents an L-valine residue or an L-isoleucine residue;'}{'sup': '3', 'Xrepresents an L-tryptophan residue or an L-phenylalanine residue;'}{'sup': a', 'b', 'a', 'b, 'one of Xand Xrepresents an amino acid residue derived from an amino acid having an azide group on a side chain and the other represents an amino acid residue derived from an amino acid having an alkynyl group on a side chain, and Xand Xare bonded to each other through a triazole bond;'}{'sub': g', 'h', 'i', 'j', 'm', 'n, "X, X, X, X, X, and Xeach represent g consecutive X's, h consecutive X's, i consecutive X's, j consecutive X's, m consecutive X's, and n consecutive X's;"}X represents an amino acid residue, and in a case where there is a plurality of X's, the plurality of X's may be the same as or different from each other;g, h, i, and j each independently represent an integer equal to or greater than 0;m and n are integers satisfying 0≤m≤9, 0≤n≤9, and 3≤m+n≤9 simultaneously; and{'sup': 1', '2', '3', 'a', 'b', 'a', '1', '2', '3', 'b, 'sub': i', 'j', 'm', 'n', 'i', 'm', 'n', 'j, 'k is an integer equal to or greater than 1, and in a case where k≥2, X, X, X, X, X, X, X, X, and Xin a repeating unit [X—X—X—X—X—X—X—X—X] each may be the same or different between the repeating units.'}2. The cyclic peptide according to that is represented by Formula (IA) claim 1 ,{'br': None, 'sup': N', '4', 'a', '1', '2', '3', 'b', '5', 'C, 'sub': g', 'p2', 'r', 'p1', 'm', 'n', 'q1', 's', 'q2', 'k', 'h, 'R—X—[X—X—X—X—X—X—X—X—X— ...
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