13-06-2013 дата публикации
Номер: US20130150575A1
The present invention relates to solid forms having a low degree of crystallinity or substantially amorphous of the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine (P027) and processes for their preparation. 110-. (canceled)11. A solid form of hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine having a degree of crystallinity below 30%.12. The solid form according to claim 11 , which is substantially amorphous.13. The solid form according to claim 12 , having a FTIR spectrum showing characteristic peaks at about: 3421 claim 12 , 3137 claim 12 , 3054 claim 12 , 2959 claim 12 , 2859 claim 12 , 2540 claim 12 , 2447 claim 12 , 1632 claim 12 , 1600 claim 12 , 1557 claim 12 , 1509 claim 12 , 1487 claim 12 , 1442 claim 12 , 1372 claim 12 , 1305 claim 12 , 1290 claim 12 , 1256 claim 12 , 1236 claim 12 , 1199 claim 12 , 1169 claim 12 , 1130 claim 12 , 1100 claim 12 , 1046 claim 12 , 1013 claim 12 , 982 claim 12 , 933 claim 12 , 917 claim 12 , 861 claim 12 , 819 claim 12 , and 748 cm.14. A process for preparing a solid form according to claim 11 , the process comprising:a) dissolving the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine in a suitable solvent or mixture of solvents, andb) evaporating the solvent or mixture of solvents.15. The process according to claim 14 , wherein said dissolving is performed at a temperature ranging from about room temperature to 120° C.16. The process according to claim 14 , wherein said evaporating of the solvent or mixture of solvents is performed at a temperature of about room temperature or above.17. The process according to claim 14 , wherein the solvent or mixture of solvents is selected from the group consisting of: water claim 14 , acetonitrile claim 14 , isopropanol claim 14 , methanol claim 14 , acetonitrile-water claim 14 , isopropanol-water claim 14 , and methanol-water.18. A process for preparing ...
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