2-[1', 2', 4'-ТРИАЗОЛ-3'-ИЛОКСИМЕТИЛЕН]АНИЛИДЫ, ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ И СРЕДСТВО БОРЬБЫ С ВРЕДОНОСНЫМИ ГРИБАМИ

Описываются новые соединения - 2-[1', 2', 4' - триазол-3'-илоксиметилен] анилиды общей формулы (I), где R1 означает C1 - C4 алкил, галоген, R2 означает водород, галоген, C1 - C4 алкил, C1 - C4 галогеналкил, C1 - C4 алкоксигруппу, R3 означает C1 - C4 алкил, фенил, незамещенный или замещенный 1 - 2 атомами галоида, С1 - C6 алкилом, C1 - C4 галоалкилом, нитро, C1 - C4 алкоксилом, C1 - C4 галоалкоксилом, фенилом или феноксигруппой, 2-пиридил, незамещенный или замещенный C1 - C4 галоалкилом, 2-пиразинил или пиридил, замещенный галоидом, R4 означает водород или C1 - C4 алкил, R5 означает C1 - C4 алкил, X означает кислород или NH, n = 0 или 1. Соединения проявляют биологическую активность и могут быть применены для борьбы с вредителями и вредными грибами с более высокой эффективностью. Описываются промежуточные продукты и средство борьбы с вредоносными грибами. 3 с.п.ф-лы, 3 табл.

Способ получения 1,2-бисгидроксиламинов

VERFAHREN ZUR HERSTELLUNG AROMATISCHER HYDROXYLAMINE DURCH HYDRIERUNG AROMATISCHER NITRODERIVATE

PROCESS FOR THE PRODUCTION OF AROMATIC HYDROXYLAMINES

... 1388523 Hydroxylamines RHONE-POU- LENC SA 29 May 1973 [29 May 1972] 25389/73 Heading C2C Hydroxylamines of Formula I in which each of R 1 , R 2 , R 3 , R 4 and R 5 is H, alkyl, cycloalkyl, phenyl, phenylalkyl or alkylphenyl, or in which at least one pair of R 1 , R 2 , R 3 , R 4 and R 5 on adjacent carbon atoms of the benzene ring, together with those two adjacent carbon atoms, forms a benzene ring, which is unsubstituted or substituted by an alkyl group, are prepared by hydrogenating a compound of Formula II in the presence of a catalyst comprising platinum and an organic base, the pKa of which is less than 3À2, the ratio of weight of the amount of organic base to that of the nitro compound being greater than 0À1 : 1. Examples of bases which can be used in the process are diethylamine, diisopropylamine, piperidine, betaine and coniine.

PREPARATION OF AROMATIC HYDROXYLAMINE

PROCESS FOR THE PREPARATION OF P-NITROSODIPHENYL HYDROXYLAMINES

Process for ther solid phase synthesis of aldehyde ketone oxim amine hydroxamic acid abd a b-unsaturated carboxyxlix acid and aldehyde compounds

Process for the solid phase synthesis of of aldehyde, ketone, oxine, amine, hydroxamic acid and B-unsaturated carboxylic acid and aldehyde compounds.

This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and a,b-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

Process for the solid phase synthesis of aldehydes ketones oximes amines and hydroxamic acid compounds

Process for the solid phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds.

New derivatives of hydroxylamine, their method of preparation, their application as growth factors of the plants and the compositions containing them.

Process for the solid phase synthesis of aldehyde,ketone, oxime, amine, hydroxamic acid and alpha, b eta-unsaturated carboxylic acid and aldehyde compounds.

Process for the solid phase synthesis of aldehydesketones oximes amines and hydroxamic acid compoun ds

Process for ther solid phase synthesis of aldehyde ketone oxim amine hydroxamic acid abd a b-unsaturated carboxyxlix acid and aldehyde compounds

Process for the solid phase synthesis of aldehydes ketones oximes amines and hydroxamic acid compounds

PROCEDURE FOR THE PRODUCTION OF A ZEOLITHHALTIGEN SOLID

MORE CYCLOHEXENONOXIMETHER, PROCEDURES AND INTERMEDIATE PRODUCTS FOR YOUR PRODUCTION AND YOUR USE THAN HERBICIDES

INHIBIERTE 141B

PROCEDURE FOR THE PRODUCTION OF HYDROXYLAMINEN.

HYDROXYL AMINE DERIVATIVES, PROCEDURES FOR ITS PRODUCTION, YOUR APPLICATION AS GROWTH FACTORS FOR VEGETABLES AND IT CONTAINING COMPOSITIONS.

PROCEDURE FOR THE PRODUCTION OF N-ALKYLSUBSTITUIERTEN HYDROXYL AMMONIUM CHLORIDE.

CARBONIC ACID DERIVATIVES.

ORNITHINE DECARBOXYLASE INHIBITIONS CYCLI AMINOOXY CONNECTIONS

BRANCHED OUT AMINOOXY AMINO ALKANE DERIVATIVES AS ORNITHIN DECARBOXYLASE INHIBITORS

PROCEDURE AND COMPOSITION FOR INHIBIERUNG POLYMERIZING OF ETHYLENISCH INSATIATED HYDROCARBONS

ANTIBIOTIC CEPHALOSPORINE SUBSTITUTED BENZYLOXYIMINO RADICAL IN POSITION 7 CARRYING

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

Retroviral protease inhibiting compounds

HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

PROCESS FOR THE PREPARATION OF A HYDROXYLAMINE

PHENYL HYDROXAMIC ACIDS INCLUDING A HETERO-CONTAINING SUBSTITUENT

QA198 PHENYL HYDROXAMIC ACIDS INCLUDING A HETERO-CONTAINING SUBSTITUENT Phenyl hydroxamic acids are disclosed having the general formula or a pharmaceutically acceptable salt thereof, wherein X is NR, oxygen, sulfur, (?)g or a single bond, and Y is NR, oxygen, sulfur, (?)g or a single bond, where R can be hydrogen or lower alkyl, g can be 1 or 2, and with the proviso that at least one of X and Y is other than a single bond; Z is aryl, aralkyl or cycloalkyl; R1 is hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl or aryl; R2 is hydrogen, QA198 lower alkyl, aroyl or acyl; m is 0 to 4 carbon atoms; and, n is 0 to 4 carbon atoms. These new compounds have been found to be inhibitors of arachidonic acid 5-lipoxygenase and are therefore useful as antiallergy agents and antipsoriatics.

ALFA-AMINOOXYLIC AMIDE DERIVATIVES

USE OF N,N-DIALKYLHYDROXYLAMINES AND THEIR PREPARATION

Use of N,N-dialkylhydroxylamines and their preparation The compounds of the formula (I) (I) wherein R1 and R2 are independently alkyl of 8 to 36 carbon atoms, are useful for stabilizing a poly(arylene sulfide) resin, a modified polystyrene or a polymer containing a diene component against thermal, oxidative or actinic degradation. N,N-Dialkylhydroxylamines of the formula (I) can be prepared by an improved process involving a reverse Michael reaction of the N-oxides of the corresponding .beta.-dialkylaminopropionic esters, amides or nitriles or of .beta.-dialkylaminosuccinyl esters or imides. N,N-Dialkylhydroxylamines of the formula (I) can also be prepared by animproved process involving the direct oxidation of the corresponding N,N-dialkylamines with aqueous hydrogen peroxide in a lower alkanol solvent.

TRACELESS REDUCTIVELY CLEAVABLE LINKER MOLECULES FOR PEPTIDE PURIFICATION

The present invention relates to linker molecules of formula (1), X-Tb-Va-U-Y-Z (1) and a method for purifying peptides using said linker molecules. The linker molecule can be coupled to a purification resin via the moiety X and to a peptide via the moiety Y under the release of the leaving group Z. T is an optional spacer moiety and V is an optional electron withdrawing moiety. U is an aryl or 5- or 6-membered heteroaryl moiety bound to at least one electron withdrawing moiety V, W or E. The linker is stable under acidic conditions and releases the peptide upon addition of a reducing agent.

FUNGICIDAL AGENTS

FUNGICIDAL AGENTS There are provided hydroxamic acids, and the esters and chelates thereof having the structure or and their use for the prevention, control or amelioration of diseases caused by phytopathogenic fungi. Further provided are compositions and methods comprising those compounds for the protection of plants from fungal infestation and disease.

COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.

COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.

2-[1',2',4'-TRIAZOL-3'-YLOXYMETHYLENE]ANILIDES, THEIR PREPARATION AND THEIR USE

The invention concerns 2-[1',2',4'-triazol-3'-~ yloxymethylene]-anilides of the formula (I) in which the subscript and substituents are as follows: n stands for 0, 1, 2, 3, or 4; X stands for a direct bond, oxygen or NR a, R a being hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl; R1 nitro, cyano, halogen or optionally substituted alkyl, alkenyl, alkinyl, alkoxy, alkenylox y or alkinyloxy; R2 hydrogen, nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, alkylthio or alkoxycarbonyl; R3 optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R4 hydrogen or optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkylcarbonyl or alkoxycarbonyl; R5 hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl. The invention also concerns methods of preparing such compounds, intermediates used in their preparation and their use in the control of animal and fungal pests .

ELECTROSYNTHESIS OF HYDROXYLAMMONIUM SALTS AND HYDROXYLAMINEUSING A MEDIATOR, A CATALYTIC FILM, METHODS OF MAKING THE CATALYTIC FILM, AND ELECTROSYNTHESIS OF COMPOUNDS USING THE CATALYTIC FILM

In one embodiment, the present invention relates to a method of making a catalytic film comprising: applying an electric current to an electrochemical cell comprising an anode, a cathode and a solution comprising a film forming compound and a nitrate ion source thereby forming the catalytic film. In another embodiment, the present invention relates to a method of preparing a hydroxylammonium salt, involving the steps of: providing an electrochemical cell containing an anode, a cathode, and a divider positioned between the anode and the cathode, to define a catholyte compartment between the cathode and the divider and an anolyte compartment between the anode and the divider; charging the catholyte compartment with a first solution comprising a nitrogen containing compound and a mediator and the anolyte compartment with a second solution comprising an ionic compound; passing a current through the electrochemical cell to produce a hydroxylammonium salt in the catholyte compartment; and recovering ...

PROCEDURE FOR THE PRODUCTION OF P-NITROSO-DIPHENYLHYDROXYLAMINEN.

Process for preparing hydroxylamino compounds or amino compounds

METHOD OF SOLID-PHASE SYNTHESIS OF ALDEHYDES, KETONES, OXIMES, AMINES AND HYDRO KSAMOVOI ACID

A PROCESS FOR THE SOLID-PHASE SYNTHESIS OF ALDEHYDES, KETONES, OXIMES, AMINES AND HYDROXAMIC ACID

A PROCESS FOR THE SOLID PHASE SYNTHESIS OF ALDEHYDE OF a, b- UNSATURATED ALKENOATE RESIN

Iminooxymethylene anilides, process and intermediate products for preparing the same and pesticides containing the same

NEW DERIVATIVES OF HYDROXYLAMINE, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS GROWTH FACTORS OF THE PLANTS

PROCESS FOR the MANUFACTURE Of HYDROXYLAMINES AND PRODUCTS THUS OBTAINED

PROCESS FOR THE PREPARATION OF AROMATIC HYDROXYLAMINES FROM NITROSO DERIVATIVES

PROCESS FOR THE PREPARATION OF ALPHA-AMINOXY-CARBOXYLIC ACIDS

PROCESS FOR THE PREPARATION OF AROMATIC HYDROXYLAMINES BY HYDRO GENATION OF AROMATIC NITRO DERIVATIVES

PROCESS FOR THE PREPARATION OF P-NITROSO-FENIL-HIDROXILAMINA AND PRODUCTS

IMINOOXYMETHYLENE ANILIDES, PROCESS AND INTERMEDIATE PRODUCTS FOR PREPARING THE SAME AND PESTICIDES CONTAINING THE SAME

Iminooxymethylene anilides have the formula in which the substituents and indices have the following meanings: R stands for hydrogen, optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, alkylcarbonyl or alk-oxycatbonyl; R1 stands for alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl and when X stands for NRa it may also stand for hydrogen; X stands for a direct bond, 0 or NRa, Ra stands for hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl; R2 stands for cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy; n equals 0, 1 or 2; R3 stands for hydrogen, hydroxy, halogen, alkyl, alkylhalide, alkoxy, alkylthio, optionally substituted cycloalkyl, heterocyclyl, aryl, arylalkyl, hetaryl or hetarylalkyl; R5 stands for hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, alkinyl, alkylcarbonyl, alkenylcarbonyl, alkinylcarbonyl or alkylsulfonyl; optionally substituted aryl, hetaryl, arylcarbonyl, herarylcarbonyl, arylsulfonyl or hetarylsulfonyl ...

PROCESS FOR SELECTIVE OXIDATION OF PRIMARY ALCOHOLS AND NOVEL CARBOHYDRATE ALDEHYDES

L'invention se rapporte à un procédé de production d'aldéhydes et/ou d'acides carboxyliques, selon lequel un alcool primaire, notamment un glucide, est oxydé à l'aide d'une quantité catalytique d'un composé nitrosonium obtenu par oxydation d'un composé nitroxyle en présence d'un enzyme susceptible d'oxyder. L'invention se rapporte en outre à des glucides oxydés contenant au moins un groupe à chaîne monosaccharide cyclique portant un groupe carbaldéhyde pour 25 unités monosaccharide et par molécule.

Hydroxylamine derivative of 5-nitro-8-hydroxy quinoline

Novel hydroxylamino derivatives of the formula Ar--ONH2 I wherein Ar is selected from the group consisting of mono- and polycyclic aromatics and hetero-aromatics, both optionally substituted with at least one member of the group consisting of --OH, halogen, --NO2, --CN, см. иллюстрацию в PDF-документе --R7, --OR8, см. иллюстрацию в PDF-документе --SO2 R12, --SO3 R13, --COOR14, aryl of 6 to 14 carbon atoms, --OR16, --CH2 --CN and --CH2 SO2 --R15, R1, R2, R3, R4, R5 and R6 are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, R7 and R8 are optionally unsaturated alkyl of 1 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen and cyano, R9, R10, R11, R12 and R13 are alkyl of 1 to 8 carbon atoms, Z is selected from the group consisting of hydrogen, optionally unsaturated alkyl of 1 to 8 carbon atoms and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R14 is selected from the group consisting ...

Fungicidal agents

There are provided hydroxamic acids, and the esters and chelates thereof having the structure см. иллюстрацию в PDF-документе and their use for the prevention, control or amelioration of diseases caused by phytopathogenic fungi. Further provided are compositions and methods comprising those compounds for the protection of plants from fungal infestation and disease.

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

A method of the preparation of N-hydroxy aspartic acid derivate

ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY

Compounds of the structure (I) where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or -NR1R2, where R1 and R2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzol[b]furyl, thienyl, or benzol[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

2-AMINO-7-CARBAMOYL-1,2,3,4-TETRAHYDRONAPHTHALENES, PROCESS FOR PREPARING THEM AND THEIR USE AS DRUGS

The invention relates to new 2-amino-7-carbamoyl-1,2,3,4-tetrahydronaphthalenes, a process for preparing them and their use as drugs.

Process for the synthesis of N,N-dialkyl-Hydroxylamines

STABILIZATION OF AQUEOUS HYDROXYLAMINE SOLUTION

PURPOSE: To stabilize the subject solution for long time by adding a small amount of a mercaptothiazole, thiosulfate, mercaptothiazolline, etc., to hydroxylamine or an at least partially nuetralized hydroxylamine salt. CONSTITUTION: The stabilized soln. of hydroxylamine or an at least partially nuetralized hydroxylamine salt for a long time is obtained by minimizing the decomposition of hydroxylamine. Therefor a compd. selected from the compd. groups of a compd. represented by formula I [where R or R1 are CHR2 (R2 is an alkyl or H) ;X is H or univalent cation], a compd. represented by formula II [R4 to R7 are each H, an alkyl or aryl; Y is -S-S-C(=S)-; (n) is 0 or 1] or a compd. represented by formula III (R8 is a polyvalent alkylene; (a) and (b) are 1-3 and (a+b) is <4) is added by effective amounts. As the stabilizers 2-mercapto-4,5-dimethylthiazoline, tetramethylthiuram disulfide, thiourea, 2- mercaptoethanol, etc., are exemplified. COPYRIGHT: (C)1993,JPO ...

СПОСОБ ПОЛУЧЕНИЯ СОДЕРЖАЩЕГО ЦЕОЛИТ ТВЕРДОГО ВЕЩЕСТВА

Изобретение относится к способам получения цеолитов. Способ получения твердого вещества, содержащего титан-силикалит-1, включает: стадию (I): по меньшей мере, частичную кристаллизацию твердого вещества, содержащего, по меньшей мере, один цеолит, из синтезной смеси с получением смеси (I), включающей, по меньшей мере, упомянутое твердое вещество, а также, по меньшей мере, одно темплатное соединение, представляющее собой гидроксид тетрапропиламмония, в качестве вспомогательного вещества; стадию (II): концентрацию твердого вещества, которое находится в смеси (I), ультрафильтрацией с получением ретентата и пермеата, причем пермеат содержит упомянутое, по меньшей мере, одно темплатное соединение; стадию (III): агломерацию или грануляцию или агломерацию и грануляцию частиц твердого вещества в ретентате со стадии (II), причем полученный на стадии (II) пермеат, содержащий упомянутое, по меньшей мере, одно темплатное соединение, по меньшей мере, частично возвращают на стадию (I), а ультрафильтрацию ...

ИНГИБИРУЮЩИЕ ОРНИТИНДЕКАРБОКСИЛАЗУ РАЗВЕТВЛЕННЫЕ АМИНООКСИАМИНОАЛКАН ПРОИЗВОДНЫЕ

Описаны соединения формулы I, указанной в описании, или их соли. Соединения формулы I и их соли ингибируют орнитиндекарбоксилазу.

СПОСОБ СЕЛЕКТИВНОГО ОКИСЛЕНИЯ ПЕРВИЧНЫХ СПИРТОВ И НОВЫЕ УГЛЕВОДНЫЕ АЛЬДЕГИДЫ

... 1. Способ окисления первичного спирта с использованием нитроксильного соединения и окислителя, отличающийся тем, что первичный спирт окисляют в присутствии фермента, способного к окислению, и/или в присутствии комплекса металла, в водной среде или в смеси воды со спиртом, эфиром или несмешиваемым с водой органическим растворителем. 2. Способ по п.1, в котором нитроксильное соединение представляет собой ди-трет-нитроксильное соединение, в частности, 2,2,6,6, -тетраметилпиперидин-1-оксил (TEMPO). 3. Способ по п.1 или 2, в котором фермент, способный к окислению, представляет собой оксидоредуктаэу. 4. Способ по п.3, в котором фермент представляет собой пероксидазу, в частности пероксидазу хрена, соевых бобов, пе-роксидазу лигнина или миело- или лакто-пероксидазу, и окислитель представляет собой перекись водорода. 5. Способ по п.3, в котором фермент представляет собой полифенольную оксидазу или лакказу и окислитель представляет собой кислород. 6. Способ по п.1 или 2, в котором фермент представляет ...

Способ получения ароматических гидроксиламинов

HYDROXAMIC ACID DERIVATIVES

CHEMICAL COMPOUNDS

SALTS OF N-NITROSOPHENYLHYDROXYLAMIN

ACETYLENE DERIVATIVES WITH LIPOXYGENASE INHIBITORI EFFECT

PROCEDURE FOR THE PRODUCTION OF N-ETHYLHYDROXYLAMIN-HYDROCHLORIDE.

OXIDIZED CARBOHYDRATES

STABILIZATION OF AQUEOUS HYDROSCYLAMINELÖSUNGEN.

PROCEDURE FOR THE FIXED PHASE SYNTHESIS OF ALDEHYDES, KETONEN AND HYDROXAMIC ACID DERIVATIVES

STABILIZED HYDROXYL AMINE SOLUTIONS

COMPOUNDS AND METHODS

Acetylenic urea derivatives having lipoxygenase inhibitory activity

A METHOD FOR THE PREPARATION OF N-ETHYL-HYDROXYLAMINE HYDROCHLORIDE

Intermediates

SUBSTITUTED AMINOXY-PROPIONAMIDES

SUBSTITUTED AMINOXY-PROPIONAMIDES Substituted aminoxy propionamide derivatives of the formula (I) (I) wherein p is 1 to 4; R' and R" are independently hydrogen, alkyl of 1 to 36 carbon atoms, cycloalkyl of 5 to 12 carbon atoms, aralkyl of 7 to 9 carbon atoms or said aralkyl substituted by alkyl of 1 to 36 carbon atoms; R2 and R3 are independently hydrogen or alkyl of 1 to 12 carbon atoms; A, when p=1, is a group -NHR4 wherein R4 is hydrogen, amino, alkyl of 1 to 18 carbon atoms or and B is a direct bond or alkylene of 1 to 10 carbon atoms; A, when p=2, is a bivalent radical of a 5-7 membered heterocyclic compound containing two nitrogen atoms in the ring with the free valencies on the nitrogen atoms, or is a group -N(R4)-B-N(R4)-and B and R4 have the meanings given above; A, when p=3, is a group of the formula or and n is 2 to 6 and R5 is hydrogen or alkyl of 1 to 4 carbon atoms; and A, when p=4, is a group of the formula or and R5 and n have the meanings ...

PROCESS FOR THE PREPARATION OF PARA-NITROSO- DIPHENYLHYDROXYLAMINES

An improved process for the preparation of para-nitroso-diphenylhydroxylamines is disclosed. One member of the group consisting of nitrosobenzene, ortho-substituted nitrosobenzenes, meta-substituted nitrosobenzenes, ortho-meta-disubstituted nitrosobenzenes and para-substituted nitrosobenzenes is reacted with one member selected from the group consisting of nitrosobenzenes ortho-substituted nitrosobenzenes, meta-substituted nitrobenzenes, and ortho-meta-disubstituted nitrosobenzenes, in the presence of an acid catalyst. The improvement comprises utilizing as the acid catalyst an acid selected from the group consisting of aliphatic, cycloaliphatic, and aromatic sulfonic acids, having a pKa equal to or less than one, perchloric acid, and trifluoroacetic acid, in an amount equal to or greater than 0.5 mol of acid per mol o{ nitroso reactants, and performing the reaction at a temperature from about -20.degree.C to about 60.degree.C.

PROCESS FOR THE SOLID PHASE SYNTHESIS OF ALDEHYDE, KETONE, OXIME, AMINE, HYDROXAMIC ACID AND .ALPHA.,.BETA.-UNSATURATED CARBOXYLIC ACID AND ALDEHYDE COMPOUNDS

This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and .alpha.,.beta.-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

PROCESS FOR PREPARING PYRIDINECARBOXYLIC ACID DERIVATIVES

N-7113A The present invention pertains to a method of preparing substituted and unsubstituted N-hydroxy-2-aminobutane diacid derivatives. The invention also pertains to the use of N-hydroxy-2-aminoethane derivatives (including the Nhydroxy-2-aminobutane diacid derivatives) in the preparation of pyridine derivatives.

2-[1', 2', 4' - ТРИАЗОЛ-3'-ИЛОКСИМЕТИЛЕН] - АНИЛИДЫ И СРЕДСТВО ДЛЯ БОРЬБЫ С ВРЕДОНОСНЫМИ ГРИБАМИ

Изобретение относится к средствам для борьбы с вредителями и вредоносными грибами. В основу изобретения была положена задача получить соединения с более высокой эффективностью. Из международной заявки WO-A 93/15046 известны 2-[1,2,4-триазол-5 илсксиметилен]анилиды, применяемые для борьбы с вредителями и вредоносными грибами. В соответствии с этим были получены 2-[2’, 2’, 4’-триазол-3’-илоксиметилен]анилиды общей формулы I где R1 - С1-С4алкил или галоген; R2 - водород, галоген, С1-С4-алкил, С1-С4-галогеналкил или С1-С4-алкокси; R3 - С1-С4-алкил, фенил, незамещенный или замещенный 1-2 атомами галогена, С1-С6алкилом, С1-С4 галогеналкилом, нитро, С1-С4-алкоксилом, С1-С4 -галогеналкоксилом, фенилом или феноксигруппой, 2-пиридил, незамещенный или замещенный С1-С4-галогеналкилом, 2-пиразинил или пиридил, замещенный галоидом; R4 - водород или С1-С4 -алкилом; R5 - С1-С4-алкил; Х - кислород или NH; N=0 или 1. Другим объектом изобретения является средство для борьбы с вредоносными грибами. 64 табл ...

Hydroxamic acids derivatives, compositions on their base, method of control of phytopathogenic fungi and prevention of infection

СПОСОБ ТВЕРДОФАЗНОГО СИНТЕЗА АЛЬДЕГИДОВ, КЕТОНОВ, ОКСИМОВ, АМИНОВ И ГИДРОКСАМОВОЙ КИСЛОТЫ

... 1. Способ получения кетона формулы в которой Rcи Ra независимо представляют собой алифатическую или ароматическую группу, включающий a) i) сочетание карбоновой кислоты формулы RaCOOH с полимерной смолой гидроксиламина формулы с образованием полимерной смолы гидроксамовой кислоты формулы и с последующим взаимодействием полимерной смолы гидроксамовой кислоты с алкилирующим или арилирующим агентом формулы Rb LG, где LG является уходящей группой, с образованием полимерной смолы N-алкилированной или N-арилированной гидроксамовой кислоты общей формулы или ii) взаимодействие полимерной смолы N-защищенного гидроксиламина формулы в которой Р является аминозащитной группой с алкилирующим или арилирующим реагентом формулы RbLG, где LG является уходящей группой, с образованием полимерной смолы N-защищенного, N-алкилированного или N-арилированного гидроксиламина формулы с последующим удалением аминозащитной группы с образованием полимерной смолы N-алкилированного или N-арилированного гидроксиламина ...

Process for the preparation of chlorinated phenylhydroxylamines

METHOD FOR PREPARING ALKOXYAMINES BY PHOTOLYSIS OF DITHIOCARBAMATES

The invention concerns a novel method for preparing alkoxyamines from nitroxide and dithiocarbamate by photolysis reaction. Said method does not generate effluent containing metals, can be performed in batch or continuously and is carried out at a temperature lower than known methods for the synthesis of alkoxyamines. © KIPO & WIPO 2008 ...

COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION

The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections. 2. The method of claim 1 , wherein the at least one compound comprises a combination of two or more of the compounds.3. The method of claim 1 , wherein the Flavivirus infection is Zika virus infection.4. The method of claim 1 , wherein the at least one compound comprises a compound in Table 7 claim 1 , or a prodrug claim 1 , metabolite claim 1 , or derivative thereof claim 1 , or a pharmaceutically acceptable salt of any of the foregoing.5. The method of claim 1 , wherein the at least one compound comprises the niclosamide compound claim 1 , and the niclosamide compound comprises:(a) niclosamide,(b) a niclosamide derivative,(c) a prodrug or metabolite of (a) or (b), or(d) a pharmaceutically acceptable salt of (a), (b), or (c).10. The method of claim 1 , wherein the at least one compound comprises an emricasan compound claim 1 , and wherein the emricasan compound comprises:(a) emricasan,(b) an emricasan derivative,(c) a prodrug or metabolite of (a) or (b), or(d) a pharmaceutically acceptable salt of (a), (b), or (c).12. The method of claim 1 , wherein the at least one compound comprises a combination of the niclosamide compound and the emricasan compound claim 1 , and wherein the niclosamide compound ...

Organic-inorganic hybrid compound, amine hydrogen iodide salt, composition for photoelectric conversion element, and photoelectric conversion element

The present invention provides a novel compound to be used in a solar cell. The compound of the present invention is an organic-inorganic hybrid compound represented by Formula (I). R 1 CH 2 N + H 3 M 1 X 1 3   (I) where, R 1 is a C1-C5 alkyl group or C2-C5 alkenyl group substituted with at least one halogen atom; M 1 is a divalent metal ion; X 1 is a monovalent halogen atom ion; and X 1 3 is formed from one type of halogen atom ion or a combination of two or more types of halogen atom ions.

Photoinitiators and method of preparing the same

본 발명은 옥심에스테르기를 포함하는 광개시제 및 이의 제조방법에 관한 것으로, 하기 화학식 1로 표시되는 광개시제에 관한 것이다. The present invention relates to a photoinitiator comprising an oxime ester group and a preparation method thereof, and to a photoinitiator represented by the following Chemical Formula 1. 화학식 1 Formula 1 (상기 화학식 1에서 R 1 ,R 3 , R 4 , R 5 , R 6 는 각각 독립적으로 수소 원자, 할로겐 원자, OH, CN, R X , OR X , SR X , COR X , OCOR X , NR X R Y , CONR X R Y 을 나타내고, (In Formula 1, R 1 , R 3 , R 4 , R 5 , R 6 are each independently a hydrogen atom, a halogen atom, OH, CN, R X , OR X , SR X , COR X , OCOR X , NR X R Y , CONR X R Y R X 및 R Y 는 C1~C6의 알킬, C1~C6의 할로알킬, NL 2 , OL 및 SL로 이루어진 군에서 선택된 하나 이상의 기로 치환된 C1~C5의 알킬, C1~C6의 알킬, 할로겐, 니트릴, OH 및COOH로 이루어진 군으로부터 선택된 하나 이상의 기로 치환 또는 비치환된 페닐 및, C2~C5의 알킬카르복실산으로 이루어진 군으로부터 선택되고, L은 수소 또는 C1~C6의 알킬이며, R X and R Y are C1 to C6 alkyl, C1 to C6 alkyl, C1 to C6 alkyl, halogen, nitrile substituted with one or more groups selected from the group consisting of C1 to C6 alkyl, C1 to C6 haloalkyl, NL 2 , OL and SL And phenyl unsubstituted or substituted with one or more groups selected from the group consisting of OH and COOH, and C 2 -C 5 alkylcarboxylic acid, L is hydrogen or alkyl of C 1 -C 6, R 2 는 수소 원자, 할로겐 원자, OH, CN, R E , OR E , SR E , COR E , OCOR, NR E R F , CONR E R F 을 나타내고, R 2 represents a hydrogen atom, a halogen atom, OH, CN, R E , OR E , SR E , COR E , OCOR, NR E R F , CONR E R F , R E 및 R F 는 C1~C6의 알킬, C1~C6의 할로알킬, NL 2 , OL 및 SL로 이루어진 군에서 선택된 하나 이상의 기로 치환된 C1~C5의 알킬, C1~C6의 알킬, 할로겐, 니트릴, OH 및COOH로 이루어진 군으로부터 선택된 하나 이상의 기로 치환 또는 비치환된 페닐 및, C2~C5의 알킬카르복실산으로 이루어진 군으로부터 선택되고, 산소원자를 포함하거나 포함하지 않은 2~6개의 탄소원자로 서로 이어져서 고리 화합물을 형성할 수 있고, L은 수소 또는 C1~C6의 알킬이며, R E and R F are C1 to C6 alkyl, C1 to C6 alkyl, C1 to C6 alkyl, halogen, nitrile substituted with one or more groups selected from the group consisting of C1 to C6 alkyl, C1 to C6 haloalkyl, NL 2 , OL and SL Phenyl unsubstituted or substituted with one or more groups selected from the group consisting of OH and COOH, ...

PROCESS FOR THE MANUFACTURE OF HYDROXYLAMINES AND PRODUCTS THUS OBTAINED

Mild reduction reaction for the production of arylhydroxylamines.

Slow reduction reaction for manufacturing arylhydroxy amine

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Patent JPH0470308B2

MELLOWED REDUCTION REACTION FOR THE PRODUCTION OF ARYLHYDROXYLAMINE.

Organic/inorganic mixed compound, amine hydrogen iodide salt, composition for photoelectric conversion elements, and photoelectric conversion element

　太陽電池に用いられる新規な化合物を提供する。本発明に係る化合物は、式（Ｉ）で示される有機無機混成化合物である。 Ｒ １ Ｙ １ Ｎ ＋ Ｈ ２ （Ｙ ２ Ｈ）Ｍ １ Ｘ １ ３ 　・・・（Ｉ） （式（Ｉ）中、Ｒ １ はＣ１～Ｃ６アルキル基、Ｃ３～Ｃ６アルケニル基またはＣ３～Ｃ６アルキニル基を表し、これらの基はハロゲン原子、Ｃ１～Ｃ４アルコキシ基またはＣ１～Ｃ４アルキルチオ基で置換されていてもよく、Ｍ １ は二価の金属イオンを表し、Ｘ １ は一価のハロゲン原子イオンを表し、複数あるＸ １ は互いに異なるハロゲン原子イオンであってもよく、Ｙ １ およびＹ ２ は何れか一方が酸素原子であり、他方が単結合であることを表している。）

Method for producing organic hydroxylamines

According to the inventive method for producing organic hydroxylamines, at least one organic nitro compound is partially hydrogenated in the presence of an organic base or ammonia, a trivalent phosphor compound and a hydrogenation catalyst. The invention is characterised in that quantities of the nitrogen base of more than 10 wt.% in relation to the organic nitro compound are used.

Process for manufacturing hydroxyl amines

Secondary amines are oxidized with hydrogen peroxide in the presence of a catalyst chosen from derivatives of zinc or cadmium. The process is applied to the preparation of di-substituted N,N-hydroxylamines such as N,N-diethylhydroxylamines and N,N-di-n-propylhydroxylamine.

Process for manufacturing hydroxyl amines, and compounds so obtained

Secondary amines are oxidized with hydrogen peroxide in the presence of a catalyst chosen from derivatives of zinc or cadmium. The process is applied to the preparation of di-substituted N,N-hydroxylamines such as N,N-diethylhydroxylamines and N,N-di-n-propylhydroxylamine.

Organic-inorganic hybrid compound, amine hydroiodide salt, composition for photoelectric conversion element, and photoelectric conversion element

Provided is a novel compound used for solar cells. The compound according to the present invention is an organic-inorganic hybrid compound represented by formula (I): (I) R 1 CH 2 N + H 3 M 1 X 1 3 . (In formula (I), R 1 represents a C1-C5 alkyl group or C2-C5 alkenyl group substituted by at least one halogen atom, M 1 represents a divalent metal ion, X 1 represents a monovalent halogen atom ion, and X 1 3 is formed by one type of halogen atom ion or by a combination of two or more types of halogen atom ions.)

Process for producing di-substituted N, N-hydroxylamine

Secondary amines are oxidized with hydrogen peroxide in the presence of a catalyst chosen from derivatives of zinc or cadmium. The process is applied to the preparation of di-substituted N,N-hydroxylamines such as N,N-diethylhydroxylamines and N,N-di-n-propylhydroxylamine.

Process for the preparation of hydroxylamines and products thereby obtained

Secondary amines are oxidized with hydrogen peroxide in the presence of a catalyst chosen from derivatives of zinc or cadmium. The process is applied to the preparation of di-substituted N,N-hydroxylamines such as N,N-diethylhydroxylamines and N,N-di-n-propylhydroxylamine.

Moderated reduction reactions for producing arylhydroxylamines

A method is provided for enhancing the production rate of arylhydroxylamines by moderated catalytic hydrogenation reactions. Small quantities of acid introduced to the reaction medium doubles the hydrogenation rate of nitroaromatic compounds without a significant loss in selectivity to arylhydroxylamines.

Preparation method of methoxyamine hydrochloride and preparation method of N-methoxyacetamide

本发明涉及一种甲氧胺盐酸盐的制备方法、N‑甲氧基乙酰胺的制备方法，属于有机合成技术领域。本发明的甲氧胺盐酸盐的制备方法包括以下步骤：1)将乙酰氧肟酸和硫酸二甲酯在水中进行甲基化反应生成N‑甲氧基乙酰胺；甲基化反应过程中采用碳酸氢钠和氢盐化钠控制反应体系的pH为7‑9，所述碳酸氢钠和氢氧化钠的摩尔比为0.03‑0.09:1；2)再将N‑甲氧基乙酰胺制成甲氧胺盐酸盐。本发明的甲氧胺盐酸盐的制备方法，甲基化反应过程中采用碳酸氢钠和氢氧化钠复合碱，不仅能够提高乙酰氧肟酸的转化率，还有助于严格控制甲基化过程中的pH为7‑9，减少多甲基化杂质(O,N‑二甲基羟胺盐酸盐)的生成，提高N‑甲氧基乙酰胺的收率。

一种o-3-氯-2-丙烯基羟胺的制备方法

本发明涉及一种O‑3‑氯‑2‑丙烯基羟胺的制备方法，其包括以下步骤：S1将羟胺水溶液、乙酸甲酯加入到烧瓶中并完全混合，再加入4‑二甲氨基吡啶催化剂，随后向烧瓶内滴加液碱后进行反应；S2再次向烧瓶加入反式‑1，3二氯丙烯，升温并维持温度进行反应；S3加入盐酸并进行搅拌，随后进行回流反应；S4、减压蒸馏分离有机物后，加入液碱调节pH；S5室温下进行萃取，随后减压蒸馏脱除溶剂，即得O‑3‑氯‑2‑丙烯基羟胺,本发明操作简单，收率高，反应安全且有效的减少杂质的产生，适用于大规模工业生产。

一种o-3-氯-2-丙烯基羟胺的制备方法

本发明涉及一种O‑3‑氯‑2‑丙烯基羟胺的制备方法，其包括以下步骤：S1将羟胺水溶液、乙酸甲酯加入到烧瓶中并完全混合，再加入4‑二甲氨基吡啶催化剂，随后向烧瓶内滴加液碱后进行反应；S2再次向烧瓶加入反式‑1，3二氯丙烯，升温并维持温度进行反应；S3加入盐酸并进行搅拌，随后进行回流反应；S4、减压蒸馏分离有机物后，加入液碱调节pH；S5室温下进行萃取，随后减压蒸馏脱除溶剂，即得O‑3‑氯‑2‑丙烯基羟胺,本发明操作简单，收率高，反应安全且有效的减少杂质的产生，适用于大规模工业生产。

一锅法制备o-烷基羟胺盐酸盐和n,o-二烷基羟胺盐酸盐的方法

本发明涉及有机合成领域，具体为一锅法制备0‑烷基羟胺盐酸盐和N，O‑二烷基羟胺盐酸盐的方法，包括以下步骤：S1乙酰化：盐酸羟胺与水以及乙酸甲酯混合，室温搅拌下滴加氢氧化钠溶液，得中间体乙酰羟胺；S2烷基化：常温下向反应釜内滴加烷基化试剂后升温反应；S3水解纯化：反应合格后加入浓硫酸升温水解，合格后加入片碱或液碱调pH＝12，常压蒸馏后用盐酸酸化、冷却结晶、离心烘干得到最终产品；本发明选用乙酸甲酯作为乙酰保护剂，与乙酸乙酯相比具有以下优点：水溶性好、反应位阻小、保护充分、杂质少以及价格成本低等优点；同时产品纯度高、工艺操作简便、原料易得、废水成分简单对环境相对友好，适宜工业化生产。

一种制备乙氧胺的方法

本发明属于化学合成，具体的说是一种制备乙氧胺的方法，乙酰氧肟酸钠盐溶液与催化剂混合，在密闭环境下，向体系中通入卤代乙烷气体或液体，得到O‑乙基乙酰氧肟酸，O‑乙基乙酰氧肟酸经水解纯化后既得乙氧胺。本发明使用卤代乙烷(氯乙烷或溴乙烷)替代硫酸二乙酯进行乙基化反应，反应原料廉价易得，且取消硫酸单乙酯水解废水预处理工艺，减少杂盐废固的产生。

一种o-3-氯-2-丙烯基羟胺的制备方法

本发明涉及一种O‑3‑氯‑2‑丙烯基羟胺的制备方法，其包括以下步骤：S1将羟胺水溶液、乙酸甲酯加入到烧瓶中并完全混合，再加入4‑二甲氨基吡啶催化剂，随后向烧瓶内滴加液碱后进行反应；S2再次向烧瓶加入反式‑1，3二氯丙烯，升温并维持温度进行反应；S3加入盐酸并进行搅拌，随后进行回流反应；S4、减压蒸馏分离有机物后，加入液碱调节pH；S5室温下进行萃取，随后减压蒸馏脱除溶剂，即得O‑3‑氯‑2‑丙烯基羟胺,本发明操作简单，收率高，反应安全且有效的减少杂质的产生，适用于大规模工业生产。

一种甲氧胺盐酸盐的制备方法、n-甲氧基乙酰胺的制备方法

本发明涉及一种甲氧胺盐酸盐的制备方法、N‑甲氧基乙酰胺的制备方法，属于有机合成技术领域。本发明的甲氧胺盐酸盐的制备方法包括以下步骤：1)将乙酰氧肟酸和硫酸二甲酯在水中进行甲基化反应生成N‑甲氧基乙酰胺；甲基化反应过程中采用碳酸氢钠和氢盐化钠控制反应体系的pH为7‑9，所述碳酸氢钠和氢氧化钠的摩尔比为0.03‑0.09:1；2)再将N‑甲氧基乙酰胺制成甲氧胺盐酸盐。本发明的甲氧胺盐酸盐的制备方法，甲基化反应过程中采用碳酸氢钠和氢氧化钠复合碱，不仅能够提高乙酰氧肟酸的转化率，还有助于严格控制甲基化过程中的pH为7‑9，减少多甲基化杂质(O,N‑二甲基羟胺盐酸盐)的生成，提高N‑甲氧基乙酰胺的收率。

一种反式-3-氯-2-丙烯基羟胺的制备方法

本发明属于有机合成技术领域，涉及一种用于生产烯草酮原药中间体和其它农药重要中间体的反式‑3‑氯‑2‑丙烯基羟胺的制备方法，具体包括以下步骤：先以反式1,3二氯丙烯为原料，先将反式1,3二氯丙烯进行水解，得到3‑氯丙烯醇；再将得到的3‑氯丙烯醇与羟胺盐在酸性催化剂催化下生成反式‑3‑氯‑2‑丙烯基羟胺。本发明的有益效果是：由于采用上述技术方案，本发明制备方法具有原料易购，操作简便，产率高，无污染易工业化生产。

一锅法制备o-烷基羟胺盐酸盐和n,o-二烷基羟胺盐酸盐的方法

本发明涉及有机合成领域，具体为一锅法制备0‑烷基羟胺盐酸盐和N，O‑二烷基羟胺盐酸盐的方法，包括以下步骤：S1乙酰化：盐酸羟胺与水以及乙酸甲酯混合，室温搅拌下滴加氢氧化钠溶液，得中间体乙酰羟胺；S2烷基化：常温下向反应釜内滴加烷基化试剂后升温反应；S3水解纯化：反应合格后加入浓硫酸升温水解，合格后加入片碱或液碱调pH＝12，常压蒸馏后用盐酸酸化、冷却结晶、离心烘干得到最终产品；本发明选用乙酸甲酯作为乙酰保护剂，与乙酸乙酯相比具有以下优点：水溶性好、反应位阻小、保护充分、杂质少以及价格成本低等优点；同时产品纯度高、工艺操作简便、原料易得、废水成分简单对环境相对友好，适宜工业化生产。