PARTIALLY FLUORINATED SULFINIC ACID MONOMERS AND THEIR SALTS

Described herein is a composition according to formula I or its precursor, formula II: CXX═CX—(R)—CZ1Z2-SOM (I) wherein X, X, and Xare independently selected from H, F, Cl, Br, I, CFand CH, and wherein at least one of X, X, or Xis a H; Ris a linking group; Z1 and Z2 are independently selected from F, Cl, Br, I, CF, and a perfluoroalkyl group; p is 0 or 1; and M is a cation; and CXXX—CXX—(R)—CZ1Z2-SOM (II) wherein X, X, and Xare independently selected from H, F, Cl, Br, I, CFand CH, wherein at least one of X, X, or Xis a H, and Xand Xare independently selected from H, F, Cl, Br and I; Ris a linking group; Z1 and Z2 are independently selected from F, Cl, Br, I, CF, and a perfluoroalkyl group, p is 0 or 1; and M is selected from F, and a cation. 2. The monomer according to claim 1 , wherein X claim 1 , X claim 1 , and Xare all H and Ris a perfluorinated group.3. The monomer according to claim 1 , wherein Ris selected from: —(CH)— claim 1 , —(CF)— claim 1 , —(CF)—O—(CF)— claim 1 , —(CF)—[O—(CF)]— claim 1 , and —[(CF)—O—]—[(CF)—O—] claim 1 , and combinations thereof claim 1 , wherein a claim 1 , b claim 1 , c claim 1 , and d are independently at least 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 10 claim 1 , 20 claim 1 , etc.5. A method comprising:(a) reacting a terminal alkene compound with a halofluorosulfonylfluoride to produce a halohydrofluorosulfonylfluoride;(b) dehalohydrogenating the halohydrofluorosulfonylfluoride to produce an alkenefluorosulfonylfluoride; and(c) reducing of the alkenefluorosulfonylfluoride to produce an alkenefluorosulfinic acid or salt.6. The method of wherein halogen of the halofluorosulfonylfluoride is selected from Br claim 5 , or I.7. The method of claim 5 , wherein the terminal alkene compound is at least one of ethylene claim 5 , CH═CCl claim 5 , CH═CF claim 5 , CH═CHF claim 5 , CH═CHCl claim 5 , and propylene.8. The method of claim 5 , wherein the halofluorosulfonylfluoride is at least one of ICFCF—O—CFCFSOF claim 5 , BrCFCF—O— ...

FLUORINATED OLIGOMERS HAVING PENDANT BROMINE-CONTAINING MOIETIES

Described herein is an oligomer having a pendant bromine-containing moiety according to formula II and/or formula III; and combinations thereof; wherein X, X, and Xare each independently selected from F, Cl, H, and CF; R is a linear or branched linking group, which may be saturated or unsaturated, substituted or unsubstituted, and may comprise a heteroatom; each Zand Zis independently selected from F and CF; n is 0 or 1; q is 0 or 1; and m is at least 2. 4. The composition according to claim 3 , wherein the monomer is selected from:{'sub': 3', '2', '4', '9', '2', '3', '2', '3', '7', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3, 'ethylene, tetrafluoroethylene, propylene, hexafluoropropylene, vinyl chloride, vinyl fluoride, a fluoroalkyl substituted ethylene, vinylidene fluoride, allyl iodide, fluorinated alkyl vinyl ethers, fluorinated alkoxy vinyl ethers, bromotrifluoroethylene, chlorotrifluoroethylene, CFCH═CH, CFCH═CH, CFOCF═CF, CFOCF═CF, CF═CFOCFCF(CF)OCFCFCF, CF═CFOCFCFCFCN, CF═CFOCFCFCFCOCH, CF═CFOCFCF(CF)OCFCFCOCH, CF═CFOCFCFCFCHOH, and CF═CFOCFCFCFOCF.'}5. The composition according to claim 1 , wherein the X claim 1 , X claim 1 , and Xare all F claim 1 , n is 1 claim 1 , and R is a perfluorinated alkylene.6. The composition according to claim 1 , wherein R is selected from: —(CH)— claim 1 , —(CF)— claim 1 , —(CF)—O—(CF)— claim 1 , —(CFCF(CF)O)— and —(CF)—[O—(CF)]— claim 1 , —[(CF)—O]—[(CF)—O]— claim 1 , —[(CF)—O—]—[(CFCF(CF)O)—]— claim 1 , and combinations thereof claim 1 , wherein a claim 1 , b claim 1 , c claim 1 , and d are each independently at least 1.9. The method according to claim 8 , wherein the energy source is added during the step of brominating the polysulfinate oligomer.10. The method according to claim 7 , wherein the brominating step is conducted in the presence of water.11. The method according to claim 8 , wherein the ...

PREPARATION OF OLIGOMERS AND CO-OLIGOMERS OF HIGHLY FLUORINATED SULFINIC ACIDS AND SALTS THEREOF

There is provided a method for preparing oligomers and co-oligomers of highly fluorinated sulfuric acids and salts thereof. 2. The method of further comprising (d) acidifying the highly fluorinated sulfinate oligomer from step (c) and extracting a highly fluorinated sulfinic acid oligomer therefrom.3. The method of further comprising (e) converting the highly fluorinated sulfinic acid oligomer from step (d) to form a salt thereof.4. The method of wherein the highly fluorinated sulfinic acid oligomer is converted to the salt thereof using an organic or inorganic base.5. The method of wherein the highly fluorinated sulfinic acid oligomer is converted to the salt thereof using ammonium hydroxide.6. The method of wherein the highly fluorinated sulfinic acid oligomer is converted to the salt thereof using sodium or potassium hydroxide.8. The method of wherein when G is a functional group claim 7 , the functional group is selected from carboxylic acids and derivatives thereof claim 7 , nitriles claim 7 , sulfonyl halides claim 7 , sulphonates claim 7 , imidates claim 7 , amidines claim 7 , alcohols claim 7 , mercaptans claim 7 , iodine claim 7 , bromine and combinations thereof.10. The method of wherein the ethylenically-unsaturated monomer is selected from CH═CH claim 9 , CF═CH claim 9 , CF═CF claim 9 , CH═CHCHI claim 9 , CF═CFCFI claim 9 , CH═CHCFCFI claim 9 , CH═CHCFCFCHCHI claim 9 , CH═CH(CF)I claim 9 , CH═CH(CF)CHCHI claim 9 , CH═CH(CF)I claim 9 , CH═CH(CF)CHCHI claim 9 , CF═CFCHCHI claim 9 , CF═CFCFCFI claim 9 , CF═CFOCFCFI claim 9 , CF═CFOCFCFCHCHI claim 9 , CF═CFOCFCFCFI claim 9 , CF═CFOCFCFCFCFI claim 9 , CF═CFOCFCFCFCHCHI claim 9 , CF═CFOCFCFCHI claim 9 , CF═CFOCFCFCFCHI claim 9 , CF═CFCFOCHCHI claim 9 , CF═CFO(CF)OCFCFI claim 9 , CH═CHBr claim 9 , CF═CHBr claim 9 , CF═CFBr claim 9 , CH═CHCHBr claim 9 , CF═CFCFBr claim 9 , CH═CHCFCFBr claim 9 , CF═CFOCFCFBr claim 9 , CF═CFCl claim 9 , CF═CFCFCl claim 9 , and combinations thereof.12. The method of wherein R1 and ...

ANTIMICROBIAL AGENT COMPRISING A CYSTEINE COMPONENT COVALENTLY BOUND TO A SUBSTRATE IN PARTICULAR BY BINDING THROUGH AN S-S BRIDGE VIA A SPACER MOLECULE

The invention relates to an antimicrobial agent where a cysteine compound is covalently bound to a substrate, in particular by binding through an S—S bridge via a spacer molecule to the substrate. The spacer comprises a carbon chain, optionally interrupted by one or more heteroatoms, e.g. O, S, N, P and Si; the chain is optionally substituted with one or more alkyl groups, preferably lower alkyl groups with 1-5 carbon atoms, hydroxyl groups or alkoxy groups. Also, the invention refers to a substrate that is coated with the antimicrobial agent of the invention. The agent has excellent antimicrobial properties and can be used to coat surfaces and substrates of various devices, such as medical devices or devices used in food handling, in order to prevent or inhibit accumulation and/or growth and/or proliferation and/or the viability of microorganisms and/or formation of biofilm. 1. Antimicrobial agent comprising a substrate with a covalently bound cysteine compound.2. Antimicrobial agent according to wherein the cysteine compound is bound through an S—S bridge via a spacer molecule to the substrate; the spacer comprises a carbon chain claim 1 , optionally interrupted by one or more heteroatoms claim 1 , e.g. O claim 1 , S claim 1 , N claim 1 , P and Si; the chain is optionally substituted with one or more alkyl groups claim 1 , preferably lower alkyl groups with 1-6 carbon atoms claim 1 , hydroxyl groups or alkoxy groups.3. Antimicrobial agent according to any one of or having the formula [{'sub': 2', 'm', '2', '2', 'n', '2', 'p', '3', '2', 'n', '2', 'p', '2', 'p', '2', '2', 'n', '3', '2, 'L is a spacer molecule selected from the group comprising (CH)where m is 1-20, preferably 1-12, 1-8 or 1-6; (CHCHO)(CH)or (CH(CH)CHO)(CH)where n is 1-1000, preferably 1-100 or 3-50, and p is 1-20, preferably 1-12, 1-10 or 1-6; the (CH)segment being bound to the disulphide bridge and may optionally be positioned between the (CHCHO)or (CH(CH)CHO) segments;'}, 'X is linking group from ...

ALLYL ETHER-TERMINATED FLUOROALKANESULFINIC ACIDS, SALTS THEREOF, AND A METHOD OF MAKING THE SAME

Described herein are allyl ether-terminated fluoroalkylsulfinic acids and salts thereof and methods of making. 1. A method comprising:(a) reacting an allylation compound in the presence of a fluoride salt with a second compound selected from the group consisting of (i) a fluorinated fluoroacyl sulfonyl fluoride; (ii) a fluorinated sultone to produce an allyl ether-terminated sulfonyl fluoride; and (iii) combinations thereof; and(b) reducing the allyl ether-terminated sulfonyl fluoride to produce an allyl ether-terminated fluoroalkanesulfinic acid.2. The method of wherein the second compound is perfluorinated or highly-fluorinated.3. The method of claim 1 , wherein the second compound comprises a halogen selected from of the group consisting of Cl claim 1 , Br claim 1 , and combinations thereof.4. The method of claim 1 , wherein the reacting takes place in the presence of a phase transfer catalyst.5. The method of claim 4 , wherein the phase transfer catalyst is selected from of the group consisting of (CHCH)NCl claim 4 , (propyl)NCl claim 4 , (butyl)NCl claim 4 , (butyl)NBr claim 4 , (butyl)PBr claim 4 , CHN(butyl)Br claim 4 , (butyl)NCHSO claim 4 , (butyl)NCFSO claim 4 , methyltrialkyl (C-C)ammonium chloride claim 4 , and combinations thereof.6. The method of claim 1 , wherein the allylation compound is represented by the general formula CHX═CX—CHX-L claim 1 , wherein X claim 1 , X claim 1 , and Xare each independently selected from the group consisting of H claim 1 , Cl claim 1 , F claim 1 , Br claim 1 , an aryl claim 1 , and a C1 to C4 alkyl group claim 1 , and L is selected from the group consisting of I claim 1 , Br claim 1 , Cl claim 1 , F claim 1 , RC(O)O— claim 1 , RS(O)O— claim 1 , RP(O)O— claim 1 , and combinations thereof claim 1 , and where each R is independently selected from the group consisting of an alkyl group claim 1 , an aryl group claim 1 , a fluorinated alkyl group claim 1 , a fluorinated aryl group.8. The method of claim 1 , wherein the ...

SMALL MOLECULE XANTHINE OXIDASE INHIBITORS AND METHODS OF USE

Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia. 115-. (canceled) This application claims priority to U.S. Provisional Application No. 61/734,409, filed Dec. 7, 2012, which is incorporated herein by reference in its entirety.Gout is caused by hyperuricemia, namely, abnormally high levels of uric acid in the blood. Gout is usually present as acute inflammatory arthritis, as well as tophi, kidney stones, or urate nephropathy. Gout affects 1-2% of adults in developed countries and represents the most common case of inflammatory arthritis in men. In the United States, gouty arthritis accounts for millions of outpatient visits annually. Furthermore, gout and hyperuricemia are associated with chronic diseases such as hypertension, diabetes mellitus, metabolic syndrome, and renal and cardiovascular disease.Xanthine oxidase (XO) is a form of a molybdoflavin protein, xanthine oxidoreductase (XOR). It plays an important role in the catabolism of purines in humans, as it catalyzes the oxidation of hypoxanthine to xanthine and then catalyzes the oxidation of xanthine to uric acid. Meanwhile, reactive oxygen species (ROS), including superoxide and HO, are generated during this process. Uric acid can serve as an antioxidant to prevent macromolecular damage by ROS. However, overproduction of uric acid can cause hyperuricemia and lead to gout and other diseases. Therefore, maintaining uric acid at normal levels represents an important therapeutic goal for the prevention of gout and related disorders. For most patients with primary gout, overproduction of uric acid is the primary cause of hyperuricemia.Currently, two drugs have been developed to treat gout. Allopurinol is the most commonly used therapy for chronic gout and has been used clinically for more than 40 years. Allopurinol lowers uric acid production by inhibiting XO activity, and is used as a first-line urate-lowering phamacotherapy. Allopurinol, ...

METHOD FOR PRODUCING OXYSULPHIDIC AND FLUORINATED DERIVATIVES IN AN IONIC LIQUID MEDIUM

The invention relates to a method for producing an oxysulphidic and fluorinated derivative in the form of a salt of formula (II) Ea-SOQ (II) comprising providing an ionic liquid compound of formula (I) in the liquid state Ea-SOOCr (II)—Ea representing the fluorine atom or a group having between 1 and 10 carbon atoms selected from fluoroalkyls, perfluoroalkyls and fluoroalkenyls; and—Q representing an onium cation, with a sulphur oxide, said ionic liquid compound of formula (I) representing at least 50 wt. % of the initial liquid reactive medium. 2. The process as claimed in claim 1 , in which the reaction medium is devoid of organic solvent of amide type.3. The process as claimed in claim 1 , in which the onium cation Qis selected from the group consisting of ammonium claim 1 , phosphonium claim 1 , pyridinium claim 1 , pyrazolinium claim 1 , imidazolium claim 1 , arsenium claim 1 , quaternary ammonium and quaternary phosphonium cations.4. The process as claimed in claim 1 , in which the onium cation Qis a quaternary phosphonium cation.5. The process as claimed in claim 1 , in which the cation Qrepresents a quaternary ammonium cation selected from the group consisting of tetraethylammonium claim 1 , tetrapropylammonium claim 1 , tetrabutylammonium claim 1 , trimethylbenzylammonium claim 1 , methyltributylammonium and Aliquat 336.6. The process as claimed in claim 1 , in which the cation Qrepresents a pyridinium cation.7. The process as claimed in claim 1 , for the preparation of a trifluoromethanesulfinic acid onium salt CF SOOQ.8. The process as claimed in claim 7 , in which the trifluoromethanesulfinic acid onium salt CFSOOQis tetrabutylphosphonium trifluoromethanesulfinate CFSOOPBu.9. A process for the preparation of a compound in the form of a salt of formula (III):{'br': None, 'sub': '3', 'sup': −', '+, 'Ea-SOQ\u2003\u2003(III)'}Ea representing a fluorine atom or a group having from 1 to 10 carbon atoms selected from the group consisting of fluoroalkyls, ...

AN IMPROVED ASYMMETRIC SYNTHESIS OF alpha-(DIARYLMETHYL) ALKYL AMINES

The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1″). 3. The process according to claim 1 , wherein the lithiating agent used at step (a) is an organolithium compound selected from n-butyl lithium (n-BuLi) claim 1 , phenyllithium claim 1 , methyllithium claim 1 , tert-butyllithium or mixture thereof.4. The process according to claim 1 , wherein the step (b) involves the cleaving of the sulfinyl substitution of the amine by treatment of the alpha-(diarylmethyl) alkyl amine compound (4) with an acid claim 1 , such as hydrochloric acid claim 1 , hydrobromic acid claim 1 , hydrofluoric acid claim 1 , nitric acid claim 1 , sulfuric acid claim 1 , phosphoric acid or a mixture thereof.7. The process according to claim 5 , wherein the lithiating agent used at step (x) is an organolithium compound selected from n-butyl lithium (n-BuLi) claim 5 , phenyllithium claim 5 , methyllithium claim 5 , tert-butyllithium or mixture thereof.8. The process according to claim 5 , wherein the step (y) involves the cleaving of the sulfinyl substitution of the amine by treatment of the sulfinyl amine compound (5) with an acid claim 5 , such as hydrochloric acid claim 5 , hydrobromic acid claim 5 , hydrofluoric acid claim 5 , nitric acid claim 5 , sulfuric acid claim 5 , phosphoric acid or a mixture thereof. The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter ...

MIXED SALTS OF HYDROXYALKANE SULFINIC ACID

The preparation and use of mixed salts of hydroxyalkane sulfinic acids and optionally hydroxyalkane sulfonic acids as a reducing agent are disclosed. The reducing power of the salts is significantly higher than the reducing power of the corresponding zinc salt. The storage stability of the salts as solids and as aqueous solution is significantly higher than one of the corresponding sodium salts. 2. The magnesium-zinc-salt of claim 1 , wherein the counterions comprise 40 to 60 mole % magnesium ions and 40 to 60 mole % zinc ions or 45 to 55 mole % magnesium ions and 45 to 55 mole % zinc ions.3. The aluminium-zinc-salt of claim 1 , wherein the counterions comprise 25 to 60 mole % aluminium ions and 40 to 75 mole % zinc ions or 30 to 50 mole % aluminium ions and 50 to 70 mole % zinc ions.4. The salt of claim 1 , wherein Ris H.5. The salt of claim 1 , wherein Ris COOH.6. The salt of claim 1 , additionally containing a mixed magnesium-zinc-salt or a mixed aluminium-zinc-salt or a mixed calcium-zinc-salt of the sulfonic acid of formula (I) wherein n is 2.7. The salt of claim 6 , which comprises the sulfinic acid salt and the sulfonic acid salt in a weight ratio of 3:1 to 1:5.8. The salt of claim 7 , which comprises the mixed magnesium-zinc-salt of the sulfinic acid and the mixed magnesium-zinc-salt of the sulfonic acid in a weight ratio of 2:1 to 1:3.9. The salt of claim 7 , which comprises the mixed aluminium-zinc-salt of the sulfinic acid and the mixed aluminium-zinc-salt of the sulfonic acid in a weight ratio of 1:1 to 1:2.10. The salt of claim 6 , which comprises less than 2 wt % of magnesium-zinc-sulfite or aluminium-zinc-sulfite.11. A salt as defined in obtainable by adjusting the pH of an aqueous solution of glyoxylic acid to 3 to 4 by reacting it with magnesium hydroxide or aluminum hydroxide or calcium hydroxide claim 6 , reacting the obtained magnesium or aluminium or calcium salt of glyoxylic acid with zinc dithionite and adjusting the pH to 4.5 to 6.12. A ...

Method for preparing oxysulphide and fluorinated derivatives in the presence of an organic solvent

The present invention concerns a method for preparing an oxysulphide and fluorinated derivative of formula (III) Ea-SO3R (III) that comprises bringing a compound of formula (II) Ea-SOOR (II)—Ea representing the fluorine atom or a group having 1 to 10 carbon atoms chosen from the fluoroalkyls, the perfluoroalkyls and the fluoroalkenyls; and—R representing hydrogen, a monovalent cation or an alkyl group; into contact, in the presence of a polar aprotic organic solvent, with an oxidising agent.

PROCESS FOR MAKING N-SULFINYL a-AMINO AMIDES

Disclosed is a process for making diastereomeric N-sulfinyl α-amino amides by reaction of chiral sulfinimines with formamides and lithium diisopropylamide. The process of the invention provides the N-sulfinyl α-amino amides in high yields and with high diastereoselectivity.

ABA RECEPTOR AGONISTS THAT MODULATE TRANSPIRATION

The present invention provides agonist compounds that activate ABA receptors, agricultural formulations comprising the agonist compounds, and methods of use for the compounds and formulations. The agricultural formulations are useful for inducing ABA responses in plant vegetative tissues, reducing abiotic stress in plants, and inhibiting germination of plant seeds. The compounds are also useful for inducing expression of ABA-responsive genes in cells that express endogenous or heterologous ABA receptors. 2. The agricultural formulation of claim 1 , wherein Zis phenyl.3. The agricultural formulation of claim 1 , wherein at most one member selected from the group consisting of A claim 1 , A claim 1 , A claim 1 , and Ais N.5. The agricultural formulation of claim 1 , wherein no more than one ring substituent ortho- to Ris halo or haloalkyl.6. The agricultural formulation of claim 1 , wherein no more than one ring substituent is halo claim 1 , haloalkyl claim 1 , nitro claim 1 , or —SR.7. The agricultural formulation of claim 1 , wherein at least one ring substituent ortho- to Ris methyl.9. The agricultural formulation of claim 8 , wherein Ris hydrogen.10. The agricultural formulation of claim 8 , wherein Rand Rare hydrogen.11. The agricultural formulation of claim 8 , wherein Rand Rare each independently selected from the group consisting of halo claim 8 , nitro claim 8 , Calkyl claim 8 , cyclopropyl claim 8 , —OR claim 8 , and —N(R).12. The agricultural formulation of claim 11 , wherein Ris hydrogen or halo.13. The agricultural formulation of claim 11 , wherein Ris Calkyl.14. The agricultural formulation of claim 13 , wherein Ris methyl.15. The agricultural formulation of claim 1 , wherein each ring substituent ortho- to Ris selected independently from the group consisting of methyl claim 1 , ethyl claim 1 , n-propyl claim 1 , chloro claim 1 , bromo claim 1 , trifluoromethyl claim 1 , methoxy claim 1 , and ethoxy.16. The agricultural formulation of claim 1 , wherein ...

SULFONYL PHOTOACID GENERATORS AND PHOTORESISTS COMPRISING SAME

New bis(sulfonyl)imide and tri(sulfonyl)methide photoacid generator compounds (“PAGs”) are provided as well as photoresist compositions that comprise such PAG compounds. 3. A photoacid generator of wherein X is a sulfonium or iodonium compound.6. (canceled)7. A photoresist composition comprising a photoacid generator compound .8. A method for forming a photoresist relief image comprising:{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'a) applying a coating layer of a photoresist composition of on a substrate;'}b) exposing the photoresist coating layer to patterned activating radiation and developing the exposed photoresist layer to provide a relief image.9. A photoresist composition comprising a photoacid generator compound of .10. A method for forming a photoresist relief image comprising:{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, 'a) applying a coating layer of a photoresist composition of on a substrate;'}b) exposing the photoresist coating layer to patterned activating radiation and developing the exposed photoresist layer to provide a relief image.11. A photoresist composition comprising a photoacid generator compound of .12. A method for forming a photoresist relief image comprising:{'claim-ref': {'@idref': 'CLM-00011', 'claim 11'}, 'a) applying a coating layer of a photoresist composition of on a substrate;'}b) exposing the photoresist coating layer to patterned activating radiation and developing the exposed photoresist layer to provide a relief image.13. A photoresist composition comprising a photoacid generator compound of .14. A method for forming a photoresist relief image comprising:{'claim-ref': {'@idref': 'CLM-00013', 'claim 13'}, 'a) applying a coating layer of a photoresist composition of on a substrate;'}b) exposing the photoresist coating layer to patterned activating radiation and developing the exposed photoresist layer to provide a relief image. This invention relates to new sulfonyl imide and methide photoacid generator compounds (“ ...

AGRICULTURAL COMPOSITIONS AND METHODS OF USE THEREOF

The present invention is directed to an agricultural composition comprising an acetyl coenzyme-A carboxylase (ACCase) inhibitor, one or more sugar alcohols and optionally, one or more auxin herbicides. The present invention is further directed to a method of controlling weeds comprising applying concurrently or sequentially an ACCase inhibitor and one or more sugar alcohols, and optionally one or more auxin herbicides to the weeds or an area in need of weed control. 1. An agricultural composition comprising an acetyl coenzyme-A carboxylase (ACCase) inhibitor and one or more sugar alcohols.2. The composition of claim 1 , wherein the ACCase inhibitor is selected from the group consisting of clethodim claim 1 , fluazifop-P-butyl and haloxyfop-R-methyl.3. The composition of claim 2 , wherein the ACCase inhibitor is clethodim.4. The composition of claim 1 , wherein the one or more sugar alcohols is selected from the group consisting of D-mannitol claim 1 , D-sorbitol claim 1 , maltitol claim 1 , erythritol claim 1 , L-arabitol claim 1 , xylitol claim 1 , 1D-chiro-inositol claim 1 , inositol claim 1 , myoinositol claim 1 , galactinol claim 1 , L-quebrachitol claim 1 , D-pinitol claim 1 , D-ononitol claim 1 , D-myo-inositol-1 claim 1 ,3-diphosphate and galactinol.5. The composition of claim 4 , wherein the one or more sugar alcohols is D-sorbitol.6. An agricultural composition comprising clethodim and D-sorbitol.7. A method of controlling weeds comprising applying concurrently or sequentially an acetyl coenzyme-A carboxylase (ACCase) inhibitor and one or more sugar alcohols to the weeds or an area in need of weed control.8. The method of claim 7 , wherein ACCase inhibitor is applied at a rate from about 1 to about 100 grams per hectare.9. The method of claim 7 , wherein the ACCase inhibitor is applied at a rate from about 30 to about 70 grams per hectare.10. The method of claim 7 , wherein the ACCase inhibitor is applied at a rate of 55.4 grams per hectare.11. The method ...

ACETAMINOPHEN CONJUGATES, COMPOSITIONS AND METHODS OF USE THEREOF

Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile. Formulations comprising the conjugates are also provided, as are methods of using the conjugates and kits comprising the conjugates. 5. A formulation comprising a compound of or and a pharmaceutically acceptable carrier.6. (canceled)7. The formulation of claim 5 , wherein the pharmaceutically acceptable carrier comprises saline.8. A method of treating a disease or condition that is responsive to acetaminophen claim 5 , comprising administering to an individual in need thereof an effective amount of a compound according to or .9. The method of claim 8 , wherein the compound or formulation is administered parenterally.10. The method of claim 8 , wherein the disease or condition is selected from the group consisting of pain claim 8 , fever claim 8 , inflammation claim 8 , ischemic injury claim 8 , and neuronal injury.11. A kit for the treatment or prevention of a disease or condition that is responsive to acetaminophen claim 8 , comprising a compound of or claim 8 , or a pharmaceutically acceptable salt thereof claim 8 , and instructions for use. This patent application claims priority to U.S. Provisional Patent Application No. 61/538,075, filed Sep. 22, 2011, the disclosure of which is incorporated herein by reference in its entirety.Acetaminophen (USAN) or paracetamol (INN) (chemically known as N-(4-hydroxyphenyl)acetamide or N-(4-hydroxyphenyl)ethanamide) is an antipyretic and analgesic commonly used to manage fever of any etiology, minor to severe pains (including post-operative pain) and a variety of aches. Acetaminophen is well tolerated and lacks many of the undesired effects of other analgesics, such as non-steroidal anti- ...

THROMBOXANE RECEPTOR ANTAGONISTS

The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype. 132-. (canceled)34. The compound of claim 33 , wherein Ris —NO.36. The compound of claim 35 , wherein Ris selected from the group consisting of an isopropyl group claim 35 , a pentyl group claim 35 , a tert-butyl group claim 35 , and a cyclohexyl group.38. The compound of claim 37 , wherein Ris selected from the group consisting of an isopropyl group claim 37 , a pentyl group claim 37 , a tert-butyl group claim 37 , and a cyclohexyl group.40. The compound of claim 39 , wherein Ris selected from the group consisting of an isopropyl group claim 39 , a pentyl group claim 39 , a tert-butyl group claim 39 , and a cyclohexyl group.42. The compound of claim 41 , wherein Ris selected from the group consisting of an isopropyl group claim 41 , a pentyl group claim 41 , a tert-butyl group claim 41 , and a cyclohexyl group. This application claims priority to, and the benefit of, U.S. Provisional Application Nos. 61/625,540, 61/625,537, and 61/625,516, each of which were filed Apr. 17, 2012, the contents of each of which are incorporated by reference herein in their entirety.The invention generally relates to compounds that function as TP antagonists for treating thrombosis.Blood clotting is an important mechanism in preventing blood loss in response to blood vessel injury. Sometimes, however, clotting occurs in the blood vessels of a healthy person in a process called thrombosis. The resulting blood clot, or thrombus, is largely ...

CHIRAL 2-ARYLPROPYL-2-SULFINAMIDE AND CHIRAL N-2-ARYLPROPYL-2-SULFINYLIMINES AND SYNTHESIS THEREOF

Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds. 3. The compound of claim 1 , wherein each Ris independently hydrogen claim 1 , methyl claim 1 , isopropyl claim 1 , furanyl claim 1 , pyridinyl claim 1 , phenyl claim 1 , biphenyl claim 1 , or naphthyl.5. The compound of claim 4 , wherein each Ror Rare independently methyl claim 4 , isopropyl claim 4 , furanyl claim 4 , pyridinyl claim 4 , phenyl claim 4 , biphenyl claim 4 , or naphthyl claim 4 , orwherein each R3 is independently hydrogen, methyl, isopropyl, furanyl, pyridinyl, phenyl, biphenyl, naphthyl, or cycloalkyl.6. The compound of claim 4 , wherein Ris phenyl claim 4 , 1-napthyl claim 4 , 2-methyl-phenyl claim 4 , 4-methyl-phenyl claim 4 , trans-Ph-CH═CH claim 4 , 2-furyl claim 4 , isobutyl claim 4 , cyclohexyl claim 4 , or —C(O)OCHCH.7. The compound of claim 4 , wherein:{'sub': '1', 'Ris hydrogen;'}{'sub': 2', '2', '3, 'Ris phenyl, 1-napthyl, 2-methyl-phenyl, 4-methyl-phenyl, trans-Ph-CH═CH—, 2-furyl, isobutyl, cyclohexyl, or —C(O)OCHCH; or'}{'sub': '3', 'Ris hydrogen or methyl.'}8. The compound of claim 1 , in a diastereomerically pure form produced substantially as described in Scheme 1 claim 1 , Scheme 2 claim 1 , Scheme 3 claim 1 , Scheme 4 claim 1 , Scheme 3.1 claim 1 , Scheme 3.2 claim 1 , Scheme 4.1 or Scheme 4.2.10. The method of claim 9 , wherein the reaction forming the compound of Formula Ia of step a proceeds substantially in the absence of compounds i3b and i4b claim 9 ,wherein the reaction forming the compound of Formula Ia of step b proceeds substantially in the absence of compounds i4b and i5b, orwherein the reaction forming the compound of Formula Ia of ...

METHOD FOR PREPARING PERFLUOROALKYL SULFINATE ESTER

The present invention discloses a method for preparing a perfluoroalkyl sulfinate ester. The method includes reacting an α-carbonyldiazo compound and a sodium perfluoroalkyl sulfinate, in an organic solvent, in the presence of anhydrous copper acetate as an optimal catalyst and tert-butyl hydroperoxide (TBHP) as a green oxidant, to obtain the perfluoroalkyl sulfinate ester. Compared to the prior art, the present method has the advantages of a wide range of reaction substrates, a short reaction time, a high reaction yield, and mild reaction conditions. The reaction does not require pre-activation of sodium perfluoroalkyl sulfinate, which can participate in the reaction directly, making reaction operations simple. The present method uses TBHP as a green oxidant and produces tert-butanol and water after reaction. Moreover, the present method avoids using a bromide or a chloride as a reaction material, and thus avoids formation of a large amount of a halide salt. 2. The method according to claim 1 , wherein the reaction of the a-carbonyldiazo compound with the sodium perfluoroalkylsulfinate is conducted at 50 to 90° C. claim 1 , for 1 to 6 hours claim 1 , in the air; the transition metal compound is a copper compound; the organic solvent is petroleum ether claim 1 , 1 claim 1 ,2-dichloroethane claim 1 , 1 claim 1 ,1 claim 1 ,1-trichloroethane claim 1 , 1 claim 1 ,1 claim 1 ,2-trichloroethane claim 1 , nitro methane claim 1 , acetonitrile claim 1 , or ethyl acetate.3. The method according to claim 2 , wherein the reaction is conducted at 60° C. claim 2 , in the air claim 2 , for 1 hour; the copper compound is anhydrous copper acetate; and the organic solvent is ethyl acetate.4. The method according to claim 3 , further comprising after the reaction is complete claim 3 , diluting with ethyl acetate claim 3 , removing ethyl acetate claim 3 , and conducting silica column chromatography to obtain the perfluoroalkylsulfinate ester.5. The method according to claim 1 , wherein ...

Method for preparing oxysulphide and fluorinated derivatives by sulphination

The invention concerns a method for preparing an oxysulphide and fluorinated derivative, said method comprising the reacting, in the presence of an organic solvent, of: i) at least one compound of formula Ea-COOR (I), in which Ea represents the fluorine atom or a group having 1 to 10 carbon atoms chosen from fluoroalkyls, perfluoroalkyls and fluoroalkenyls and R represents hydrogen, a monovalent cation or an alkyl group, and ii) a sulphur oxide, said method being such that the initial molar ratio (sulphur oxide/compound of formula (I)) is less than 0.4 and the concentration of sulphur oxide dissolved in the reaction medium is kept constant for the entire duration of the reaction to a value of between 0.2% and 3% by weight by means of continually adding said sulphur oxide to the reaction medium.

磺酸盐组合物及其用于颜色稳定的用途

磺酸盐组合物包括式(I)的化合物，其中n是1或2，R 1 是H或C 1 ‑C 6 烷基，R 2 是COOM、SO 3 M或CH(OH)SO 2 ‑OM，各M是当量的多价金属，优选镁、钙、铝、锌及它们的组合。其中n为1的化合物与其中n为2的化合物的摩尔比低于0.1。所述磺酸盐组合物可用于非生物有机物质的颜色稳定，所述有机物质例如来自漆、油漆、粉末涂料和聚合物，特别是吸水性聚合物。

processes for purifying and preparing trifluoromethanesulfinic acid and for preparing fipronyl.

Method for producing sulfaminecarboxylic acid derivative

Plant growth regulator

The method of obtaining perchloromethylmercaptan

METHOD FOR PRODUCING SULFAMATE-CARBOXYLATE DERIVATIVES

1. Способ получения соединения формулы (III): ! ! в которой R1 обозначает водород, необязательно замещенный низший алкил, необязательно замещенный арил или необязательно замещенный арил низший алкил, и R2 обозначает необязательно замещенный низший алкил, необязательно замещенный циклоалкил или необязательно замещенный арил, ! его соли или сольвата, ! характеризующийся взаимодействием соединения формулы (I): ! ! в которой R1 имеет такое же значение, как определено выше, ! его соли или сольвата с соединением формулы (II): ! ! в которой R2 имеет такое же значение, как определено выше, и Hal обозначает галоген, ! в толуоле в присутствии по меньшей мере одного дополнительного компонента, выбранного из группы, состоящей из воды, спирта, диметилформамида, диметилацетамида и диметоксиэтана. ! 2. Способ по п.1, в котором дополнительным компонентом является вода или изопропанол. ! 3. Способ получения соединения формулы (IV): ! ! в которой R1 и R2 имеют такие же значения, как определено выше, ! его соли или сольвата, ! характеризующийся получением соединения формулы (III), его соли или сольвата способом по п.1 и окислением полученного соединения, его соли или сольвата. ! 4. Способ получения соединения формулы (IVb): ! ! в которой R2 имеет такое же значение, как определено выше, ! его соли или сольвата, ! характеризующийся гидролизом соединения формулы (IIIa): ! ! в которой R1а обозначает необязательно замещенный низший алкил, необязательно замещенный арил или необязательно замещенный арил низший алкил, и R2 имеет такое же значение, как определено выше, ! его соли или сольвата с получением соединения формулы (IIIb): ! ! в которой R2 имеет такое же значение, как определено в� РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2007 140 250 (13) A (51) МПК C07C 313/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21), (22) Заявка: 2007140250/04, 30.03.2006 (71) Заявитель(и): СИОНОГИ ЭНД КО., ЛТД. (JP) (30) Конвенционный ...

Herbicidic composition

Novel selective herbicidal compositions comprising an herbicidally effective amount of at least one compound selected from the group consisting of N-methyl-N-isopropylthio-N'-phenyl-urea, N-methyl-N-(2-chloroethylthio)-N'-(3,4-dichlorophenyl)-urea, N-methyl-N-n-butylthio-N'-(4-isopropylphenyl)-urea, N-methyl-N-isopropylthio-N'-(4-isopropylphenyl)-urea, N-methyl-N-isopropylthio-N'-(3,4-dimethylphenyl)-urea and N-methyl-N-n-butylthio-N'-(3,4-dimethylphenyl)-urea and a carrier and a method of selectively killing weeds in cereal crops and fields of beets.

METHOD FOR PRODUCING TRIFFORMAL SULFIC ACID SALT

1. Способ получения соли трифлиновой кислоты высокой степени чистоты из водной смеси, содержащей ее в комбинации с солью трифторуксусной кислоты и солевыми примесями, образующейся в результате способа ее получения, отличающийся тем, что указанную смесь подвергают следующим операциям: ! - первое подкисление, регулируемое таким образом, что выделяют, в основном, соль трифторуксусной кислоты в ее кислой форме, при этом преобладающее количество трифлиновой кислоты остается в солевой форме, ! - возможное отделение солей, образованных из кислоты, которая была использована для подкисления, и выделение водной фазы, ! - извлечение трифторуксусной кислоты из выделенной водной фазы, содержащей соль щелочного металла трифлиновой кислоты, трифторуксусную кислоту, трифлиновую кислоту, избыток сильной кислоты, с получением водной фазы, обедненной трифторуксусной кислотой, но содержащей соль щелочного металла трифлиновой кислоты, ! - выделение соли щелочного металла трифлиновой кислоты из водной фазы. ! 2. Способ по п.1, отличающийся тем, что водная смесь представляет собой водный раствор с содержанием сухих веществ от 10 до 40 мас.%, содержащий: ! - от 5 до 35 мас.% соли трифлиновой кислоты, предпочтительно соли щелочного металла, ! - от 5 до 35 мас.% соли трифторуксусной кислоты, предпочтительно соли щелочного металла, ! - от 0,5 до 2 мас.% солевых примесей. ! 3. Способ по п.2, отличающийся тем, что вышеупомянутый водный раствор содержит от 15 до 20 мас.% соли трифлиновой кислоты, от 10 до 15 мас.% соли трифторуксусной кислоты и от 0,5 до 2 мас.% солевых примесей. ! 4. Способ по п.1, отличающийся тем, что осуществляют подкисление с помощью серной, соляной РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2010 126 090 (13) A (51) МПК C07C 313/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (71) Заявитель(и): РАДИА ОПЕРАСЬОН (FR) (21)(22) Заявка: 2010126090/04, 25.11.2008 Приоритет(ы): (30) Конвенционный приоритет: 27.11.2007 FR 0708282 (85) Дата начала ...

METHOD FOR PRODUCING COMPLEX ETHERIC FLUOROLCANESULPHIC ACIDS

1. Способ получения сложного эфира фторалкансульфиновой кислоты, отличающийся тем, что он включает реакцию фторалкансульфиновой кислоты с органическим карбонатом, приводящую к образованию сложного эфира фторалкансульфиновой кислоты и диоксида углерода, который выделяется в ходе реакции.2. Способ по п.1, отличающийся тем, что фторалкансульфиновая кислота отвечает следующей формулев которой:- Х обозначает атом водорода или атом фтора,- n обозначает число в интервале от 1 до 8.3. Способ по п.2, отличающийся тем, что фторалкансульфиновая кислота представляет собой дифторметансульфиновую кислоту, перфторалкансульфиновую кислоту, которая, предпочтительно, представляет собой трифторметансульфиновую кислоту, перфторбутансульфиновую кислоту, перфтороктансульфиновую кислоту.4. Способ по п.2, отличающийся тем, что фторалкансульфиновая кислота представляет собой трифторметансульфиновую кислоту.5. Способ по одному из пп.1-4, отличающийся тем, что органический карбонат отвечает следующей общей формулев которой:- Rобозначает:- алкильную группу, линейную или разветвленную, содержащую от 1 до 6 атомов углерода,- циклоалкильную группу, содержащую от 5 до 6 атомов углерода,- циклоалкильную группу, содержащую от 5 до 6 атомов углерода, замещенную одной, двумя или тремя алкильными группами, содержащими от 1 до 4 атомов углерода, и/или одним или двумя атомами галогена,- фенильную группу,- фенильную группу, замещенную одной, двумя или тремя алкильными группами, содержащими от 1 до 4 атомов углерода, и/или одним или двумя атомами галогена,- Rобозначает:- алкильную группу, линейную или разветвленную, содержащую от 1 до 6 атомов углерода,- циклоа� РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 313/04 (13) 2011 149 259 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2011149259/04, 29.04.2010 (71) Заявитель(и): РОДИА ОПЕРАСЬОН (FR) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): БЮИЗИН Оливье (FR) 04.05.2009 FR 0902136 ( ...

Method of producing trifluoromethanesulphinic acid

FIELD: chemistry. SUBSTANCE: invention relates to an improved method of producing trifluoromethanesulphinic acid of high purity from an aqueous mixture containing a salt of trifluoromethanesulphinic acid, a salt of trifluoroacetic acid and salt impurities formed from a method for production thereof, where said mixture is subjected to the following operations: acidification in order to separate salts of trifluoroacetic acid and triflic acid in form of an acid, using a strong acid having pKa value less than or equal to 1; separating trifluoroacetic and trifluoromethanesulphinic acid by distillation with extraction of trifluoroacetic acid from the overhead distillate, and trifluoromethanesulphinic acid together with excess strong acid, salts of strong acids, particularly salts formed as a result of acidification, and water from the bottom part of the distillation column; separating by distillation of the trifluoromethanesulphinic present in the still residue of distillation obtained before that. EFFECT: obtaining trifluoromethanesulphinic acid of high purity from an aqueous mixture containing a salt of trifluoromethanesulphinic acid. 19 cl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 471 777 (13) C2 (51) МПК C07C 313/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2010126162/04, 25.11.2008 (24) Дата начала отсчета срока действия патента: 25.11.2008 (73) Патентообладатель(и): РОДИА ОПЕРАСЬОН (FR) (43) Дата публикации заявки: 10.01.2012 Бюл. № 1 2 4 7 1 7 7 7 (45) Опубликовано: 10.01.2013 Бюл. № 1 (56) Список документов, цитированных в отчете о поиске: ЕР 0735023 А, 02.10.1996. WO 01/49659 А, 12.07.2001. RU 2160252 С2, 10.12.2000. С.Harzdorf et al. «Uber Perfluoralkansulfinsauren» LIEBIGS ANNALEN DER CHEMIE, no. 1, 22.02.1973, pp.33-39. 2 4 7 1 7 7 7 R U (86) Заявка PCT: EP 2008/066161 (25.11.2008) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 28.06.2010 (87) Публикация заявки ...

METHOD FOR OBTAINING OXISULPTED AND FLUORINE-CONTAINING ORGANIC DERIVATIVES

1. Способ получения органического оксисульфированного и фторсодержащего производного, включающий проведение реакции в присутствии органического полярного апротонного растворителя: ! (i) фторкарбоновой кислоты формулы Ea-CF2-COOH (I), где Еа означает электроноакцепторный атом или группу, по меньшей мере, частично превращенную в соль органическим или минеральным катионом, ! (ii) с оксидом серы, предпочтительно двуокисью серы, ! отличающийся тем, что отношение числа молей оксида серы к числу молей фторкарбоновой кислоты меньше 1, предпочтительно меньше 0,99. ! 2. Способ по п.1, отличающийся тем, что отношение числа молей оксида серы к числу молей фторкарбоновой кислоты составляет 0,4-0,95, предпочтительно 0,7-0,9. ! 3. Способ по п.1, отличающийся тем, что фторкарбоновая кислота, отвечающая формуле (I), в которой группа Еа обладает электроноакцепторным эффектом на атом дифторсодержащего углерода, предпочтительно выбрана из функциональных групп, у которых константа Гаммета равна, по меньшей мере, 0,1. ! 4. Способ по п.1, отличающийся тем, что соответствующая фторкарбоновая кислота представляет собой галогенфторуксусную кислоту формулы (Ia): ! X-CF2-COOH (Ia), ! где Х означает атом фтора. ! 5. Способ по п.1, отличающийся тем, что соответствующая фторкарбоновая кислота представляет собой кислоту формулы (Ib): ! R-G-CF2-COOH (Ib), ! где G означает функциональную группу C=O, S=O, ! G означает перфторалкиленовую группу -(CF2)n-, где n больше или равно 1, ! R означает атом галогена, предпочтительно хлор или фтор, ! R означает инертный органический или минеральный остаток, предпочтительно органический радикал, такой как арил, алкил или аралкил, возможно замещенный, ! R может пред РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2008 146 510 (13) A (51) МПК C07C 313/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (71) Заявитель(и): РОДИА ОПЕРАСЬОН (FR) (21), (22) Заявка: 2008146510/04, 18.04.2007 (30) Конвенционный ...

Manufacture of trifluoromethylated acid

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Manufacture of alkyll22chloropropionate

Method of producing fluoroalkanesulphinic acid esters

Изобретение относится к способу получения сложных эфиров фторалкансульфиновых кислот. В частности, к получению сложных эфиров трифторметансульфиновой кислоты, называемой обычно "трифлиновой кислотой". Способ получения сложного эфира фторалкансульфиновой кислоты согласно изобретению отличается тем, что он включает в себя реакцию фторалкансульфиновой кислоты формулы: с органическим карбонатом формулы , приводящую к образованию сложного эфира фторалкансульфиновой кислоты и диоксида углерода, который выделяется во время реакции. 11 з.п. ф-лы, 1 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 495 026 (13) C2 (51) МПК C07C 313/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2011149259/04, 29.04.2010 (24) Дата начала отсчета срока действия патента: 29.04.2010 (73) Патентообладатель(и): РОДИА ОПЕРАСЬОН (FR) R U Приоритет(ы): (30) Конвенционный приоритет: 04.05.2009 FR 0902136 (72) Автор(ы): БЮИЗИН Оливье (FR) (43) Дата публикации заявки: 10.06.2013 Бюл. № 16 C 2 2 4 9 5 0 2 6 R U C 2 (56) Список документов, цитированных в отчете о поиске: D.T. SAUER, ЕТ AL., "Chemistry of trifluoromethyl sulphinyl fluoride. Trifluoromethylsulphinamides and trifluoromethylsulphinate esters". Inorganic chemistry, vol.10, no.2, 1971, p.p.358-362. J.B. HENDRICKSON, ET AL., "Synthetic manipulation of the triflone group. Formation from alcohols, constructions, and conversion to ketones and amines", Tetrahedron, vol.32, no.14, 1976, p.p.1627-1635. UA 64730 C2, 15.03.2004. (85) Дата начала рассмотрения заявки PCT на национальной фазе: 05.12.2011 (86) Заявка PCT: EP 2010/055820 (29.04.2010) (87) Публикация заявки РСТ: WO 2010/127991 (11.11.2010) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры" (54) СПОСОБ ПОЛУЧЕНИЯ СЛОЖНЫХ ЭФИРНЫХ ФТОРАЛКАНСУЛЬФИНОВЫХ КИСЛОТ (57) Реферат: Изобретение относится к способу получения сложных эфиров фторалкансульфиновых кислот. В частности ...

Method of obtaining perchlormercaptan

Process for the production of a dipeptide derivative

The present invention is related to a novel and improved process for the manufacture of compounds of formula (I) or salts thereof herein designated as benzylsulfonyl-Ser-X-4-amidinobenzylamide, wherein R is a C 1 to C 6 linear or branched aliphatic hydrocarbon chain optionally substituted with a C 6 to C 10 aromatic group.

Process for producing sulfinate with low content exogenous salt

本发明涉及一种在pH＞6下，通过使用羰基化合物或亚胺还原碱金属或碱土金属或铵的连二亚硫酸盐制备具有低含量外来盐的亚磺酸盐的方法。连二亚硫酸盐与羰基或亚胺化合物的摩尔比优选在0.75－1.3的范围内。本方法提供了具有低含量外来盐的亚磺酸盐产物。如果需要，可以使用常规技术进一步除去形成的外来盐。本方法尤其可用于制备羟甲基亚磺酸盐。

Synthetic method of 4-methylsulfonyl methylbenzene

本发明公开了一种4-甲磺酰基甲苯的合成方法，依次进行如下步骤：以4-甲基苯磺酰氯为起始原料，经熔融进料，在碱性水溶液中与亚硫酸钠发生还原反应，从而生成4-甲基苯亚磺酸钠；甲基苯亚磺酸钠与氯甲烷进行甲基化反应，反应所得产物经过滤、重结晶等后处理，得产品4-甲磺酰基甲苯。本发明一锅法将氯磺酰基转化成甲磺酰基，简化了生产设备和工艺操作，减少了物料转移带来的损失，提高了产品收率。

Preparation method of N-Boc- (R) -2-amino-4, 4-dimethylpentanoic acid

本发明公开了一种N‑Boc‑(R)‑2‑氨基‑4,4‑二甲基戊酸的制备方法，属于有机合成领域。一种N‑Boc‑(R)‑2‑氨基‑4,4‑二甲基戊酸的制备方法，合成路线为： 本发明的N‑Boc‑(R)‑2‑氨基‑4,4‑二甲基戊酸的制备方法，这种制备方法所用原料廉价易得、成本低、工艺操作方便、安全且产品收率高，适于工业化生产，具有广阔的应用前景。

Substituted alpha,alpha-dichloro-methane-sulfenyl chlorides and their manufacture

1. A COMPOUND OF THE FORMULA NC-C(-X)(-CL)-S-CH2-BENZENE WHEREIN X IS HYDROGEN OR CHLORO.

Process for preparing oxysulfide and fluorinated compounds

本发明涉及一种用于制备氧硫化物和氟化化合物的方法，该方法包括在有机溶剂存在下使至少一种具有式Ea‑X(I)的化合物(其中Ea是氟原子或选自氟烷基、全氟烷基和氟烯基的优选具有从1至10个碳原子的基团，并且X是溴、氯或碘)和硫氧化物反应，所述方法使得溶解在该反应介质中的硫氧化物的浓度保持在按重量计0.2％与3％之间的值。还描述了由此获得的氧硫化物和氟化化合物用于合成具有式(Ea‑SO 2 ) 2 NH的磺酰亚胺化合物及其盐(Ea‑SO 2 ) 2 NM、具有式Ea‑SO 2 OH的氟化磺酸化合物或具有式(Ea‑SO 2 ) 2 O的氟化磺酸酐化合物的用途。

PROCESS FOR THE PREPARATION OF A TRIFLUOROMETHANESULFINIC ACID

Patent FR2459221B1

REAGENT AND METHOD OF PERHALOGENOALKYLATION FOR NUCLEOPHILE USING SULFUR DIOXIDE.

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINE DERIVATIVES IN THE PRESENCE OF AN ORGANIC SOLVENT

La présente invention concerne un procédé de préparation d'un dérivé oxysulfuré et fluoré de formule (III) Ea-SO3R (III) comprenant la mise en contact, en présence d'un solvant organique, d'un composé de formule (II) Ea-SOOR (II) - Ea représentant l'atome de fluor ou un groupe ayant de 1 à 10 atomes de carbone choisi parmi les fluoroalkyles, les perfluoroalkyles et les fluoroalkényles ; et - R représentant l'hydrogène, un cation monovalent ou un groupe alkyle ; avec un agent oxydant. The present invention relates to a process for the preparation of an oxysulfide and fluorinated derivative of formula (III) Ea-SO3R (III) comprising bringing into contact, in the presence of an organic solvent, a compound of formula (II) Ea -SOOR (II) - Ea representing the fluorine atom or a group having from 1 to 10 carbon atoms chosen from fluoroalkyls, perfluoroalkyls and fluoroalkenyls; and - R representing hydrogen, a monovalent cation or an alkyl group; with an oxidizing agent.

PROCESS FOR THE PREPARATION OF A TRIFLUOROMETHANESULFINIC ACID SALT

La présente invention a pour objet un procédé de préparation d'un sel de l'acide trifluorométhanesulfinique de haute pureté.Le procédé de l'invention de préparation d'un sel de l'acide trifluorométhanesulfinique de haute pureté, à partir d'un mélange aqueux le comprenant associé à un sel d'acide trifluoroacétique et des impuretés salines résultant de son procédé de préparation, est caractérisé par le fait que ledit mélange est soumis aux opérations suivantes :- première acidification contrôlée de telle sorte que l'on libère essentiellement le sel de l'acide trifluoroacétique sous sa forme acide, la majorité de l'acide trifluorométhanesulfinique restant sous une forme salifiée,- séparation éventuelle des sels provenant de l'acide ayant servi à l'acidification et récupération d'une phase aqueuse,- traitement de la phase aqueuse séparée comprenant le sel alcalin de l'acide triflinique, l'acide trifluoroacétique, l'acide triflinique, l'acide fort en excès à l'aide d'un solvant organique susceptible d'extraire les acides organiques formés (acide trifluoroacétique, acide triflinique),- séparation des phases organique et aqueuse,- récupération du sel alcalin de l'acide triflinique à partir de la phase aqueuse. The present invention relates to a process for the preparation of a salt of trifluoromethanesulfinic acid of high purity. The process of the invention for the preparation of a salt of trifluoromethanesulfinic acid of high purity, from a mixture aqueous comprising it combined with a salt of trifluoroacetic acid and salt impurities resulting from its preparation process, is characterized in that said mixture is subjected to the following operations: - first controlled acidification so that essentially the salt of trifluoroacetic acid in its acid form, the majority of the trifluoromethanesulfinic acid remaining in a salified form, - possible separation of the salts originating from the ...

Preparation method of enantiopure tert-butyl sulfinamide

本发明公开了一种对映纯叔丁基亚磺酰胺的制备方法，用叔丁基二硫醚与双氧水进行选择性氧化，随后与酰化试剂得到叔丁基亚磺酰氯或叔丁基亚磺酰溴，随后与水合肼得到叔丁基亚磺酰肼，再与酒石酸拆分剂进行拆分解离，锌醋酸裂解后得到对映纯叔丁基亚磺酰胺。本发明工艺操作简便稳定，产率高，环境友好，较现有的工艺，原料价廉易得，降低了现有对映纯叔丁基亚磺酰胺的生产成本，有利于工业化规模生产。

PROCESS FOR THE TREATMENT OF A REACTION MIXTURE CONTAINING A SALT OF SULFINIC ACID OF WHICH THE SULFUR CARBON IS PERFLUOROUS

Use of phosphorus derivatives as stabilizing agents for perchloromethyl mercaptan

USE OF PHOSPHORUS DERIVATIVES AS STABILIZING AGENTS FOR PERCHLOROMETHYL MERCAPTAN Abstract of the Disclosure A method for stabilizing perchloromethyl mercaptan by including therein effective amounts of phosphorus derivatives.

PROCESS FOR THE MANUFACTURE OF TRIFLUOROMETHANESULFENYL CHLORIDE

Fungicidal composition based on trihalovinylsulfenyl halides

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINATED COMPOUNDS

L'invention concerne un procédé de préparation d'un composé oxy sulfuré et fluoré comprenant la mise en réaction, en présence d'un solvant organique d'au moins un composé de formule Ea-X (I), où Ea représente un atome de fluor ou un groupe ayant de préférence de 1 à 10 atomes de carbone choisi parmi les fluoroalkyles, les perfluoroalkyles et les fluoroalkényles, et X représente le brome, le chlore ou l'iode, et d'un oxyde de soufre, ledit procédé étant tel que la concentration en oxyde de soufre dissous dans le milieu réactionnel est maintenue à une valeur comprise entre 0,2% et 3% poids. L'utilisation d'un composé oxysulfuré et fluoré ainsi obtenu pour la synthèse d'un composé sulfonimide de formule (Ea-SC2)2NH et de ses sels (Ea-SC2)2NM, d'un composé acide sulfonique fluoré de formule Ea-SO2OH ou d'un composé anhydride sulfonique fluoré de formule (Ea-SC2)2O est également décrite. The invention relates to a process for the preparation of a fluorinated oxy-sulfide compound comprising reacting, in the presence of an organic solvent, at least one compound of formula Ea-X (I), wherein Ea represents an atom of fluorine or a group preferably having 1 to 10 carbon atoms chosen from fluoroalkyls, perfluoroalkyls and fluoroalkenyls, and X represents bromine, chlorine or iodine, and an oxide of sulfur, said process being such that the concentration of sulfur oxide dissolved in the reaction medium is maintained at a value between 0.2% and 3% by weight. The use of an oxysulfurized and fluorinated compound thus obtained for the synthesis of a sulfonimide compound of formula (Ea-SC2) 2NH and of its salts (Ea-SC2) 2NM, of a fluorinated sulfonic acid compound of formula Ea- SO2OH or a fluorinated sulfonic anhydride compound of formula (Ea-SC2) 2O is also described.

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINE DERIVATIVES IN THE PRESENCE OF AN ORGANIC SOLVENT

La présente invention concerne un procédé de préparation d'un dérivé oxysulfuré et fluoré de formule (III) Ea-SO3R (III) comprenant la mise en contact, en présence d'un solvant organique, d'un composé de formule (II) Ea-SOOR (II) - Ea représentant l'atome de fluor ou un groupe ayant de 1 à 10 atomes de carbone choisi parmi les fluoroalkyles, les perfluoroalkyles et les fluoroalkényles ; et - R représentant l'hydrogène, un cation monovalent ou un groupe alkyle ; avec un agent oxydant. The present invention relates to a process for preparing an oxysulfurized and fluorinated derivative of formula (III) Ea-SO3R (III) comprising contacting, in the presence of an organic solvent, a compound of formula (II) Ea -SOOR (II) - Ea representing the fluorine atom or a group having 1 to 10 carbon atoms selected from fluoroalkyls, perfluoroalkyls and fluoroalkenyls; and - R representing hydrogen, a monovalent cation or an alkyl group; with an oxidizing agent.

PROCESS FOR THE PREPARATION OF PERHALOGENOMETHANESULFINIC AND SULFONIC ACIDS AND THEIR SALTS

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINE ORGANIC DERIVATIVES

Reagent and process for the perhaloalkylation of a nucleophile using sulphur dioxide

The present invention relates to a perfluoroalkylating reagent and to its process of use. This reagent contains: - a polar solvent which is advantageously aprotic; - sulphur dioxide; - a reducing agent where the said reducing agent is a soluble derivative of formic acid, the oxidation of which does not produce inorganic (an)ions; - a perfluoroalkyl halide (chlorine, bromine or iodine, preferably the last two). Application to organic synthesis.

PROCESS FOR THE PRODUCTION OF TRIFLUOROMETHANESULFENYL CHLORIDE

L'invention concerne un procédé pour la fabrication du chlorure de trifluorométhanesulfényle à partir du disulfure de bis-(trifluorométhyle). Selon l'invention, on fait réagir le disulfure le bis-(trifluorométhyle) avec le chlore en phase liquide en présence d'un acide fort. The invention relates to a process for the manufacture of trifluoromethanesulfenyl chloride from bis- (trifluoromethyl) disulfide. According to the invention, the disulfide bis- (trifluoromethyl) is reacted with chlorine in the liquid phase in the presence of a strong acid.

REAGENT AND METHOD FOR THE SYNTHESIS OF ORGANIC OXYSULFIDE AND FLUORINATED DERIVATIVES

Process for the production of aldehydesulfoxylates

PROCESS FOR THE PURIFICATION OF TRIFLUOROMETHANESULFINATE AND SODIUM SULFONATE

PROCESS FOR PREPARING PERFLUOROALCANE-CARBOXYLIC AND PERFLUOROALCANE-SULFINIC ACID DERIVATIVES

Procédé de préparation de dérivés d'acides perfluoroalcane carboxyliques et d'acides perfluoroalcane sulfiniques consistant à faire réagir un halogenure de perfluoroalkyle RF X où X représente un atome de chlore, brome ou iode et RF une chaîne perfluorée linéaire ou ramifiée comportant de 2 à 12 atomes de carbone avec du CO2 ou du SO2 , en milieu solvant et en présence de zinc activé ou non. Process for the preparation of derivatives of perfluoroalkane carboxylic acids and perfluoroalkane sulfinic acids, consisting in reacting a perfluoroalkyl halide RF X where X represents a chlorine, bromine or iodine atom and RF a linear or branched perfluorinated chain comprising from 2 to 12 carbon atoms with CO2 or SO2, in a solvent medium and in the presence of activated zinc or not.

Process for preparing perchloromethylmercaptan

Improvement in the manufacture of aldehydesulfoxylates

PROCESS FOR THE PREPARATION OF ALKYL CHLORO-2 PROPIONATE BY CHLORINATION OF ALKYL LACTATE

L'INVENTION CONCERNE LA PREPARATION DE CHLORO-2 PROPIONATE D'ALCOYLE, RACEMIQUE OU OPTIQUEMENT ACTIF, A PARTIR DE LACTATE D'ALCOYLE RACEMIQUE OU OPTIQUEMENT ACTIF. CE PROCEDE CONSISTE, EN UNE PREMIERE ETAPE, A METTRE GRADUELLEMENT EN CONTACT LE LACTATE D'ALCOYLE ET LE CHLORURE DE THIONYLE, EN PRESENCE D'UNE QUANTITE EFFICACE D'UNE BASE ORGANIQUE TELLE QUE LA PYRIDINE, EN MAINTENANT DANS LE MELANGE REACTIONNEL UN EXCES MOLAIRE DE CHLORURE DE THIONYLE D'AU MOINS 2,5 PAR RAPPORT A LA QUANTITE DE LACTATE D'ALCOYLE INTRODUITE DANS CE MELANGE, A UNE TEMPERATURE INFERIEURE A LA TEMPERATURE DE DECOMPOSITION DU CHLOROSULFINATE DE LACTATE D'ALCOYLE FORME INTERMEDIAIREMENT PUIS, EN CE QUE, EN UNE DEUXIEME ETAPE, LE MELANGE REACTIONNEL RESULTANT DE LA PREMIERE ETAPE EST CHAUFFE A UNE TEMPERATURE AU MOINS EGALE A LA TEMPERATURE DE DECOMPOSITION DU CHLOROSULFINATE DE LACTATE D'ALCOYLE. LES CHLORO-2 PROPIONATES D'ALCOYLE SONT UTILISABLES POUR LA FABRICATION DES ACIDES PHENOXY-2 PROPIONIQUES, RACEMIQUES OU OPTIQUEMENT ACTIFS. THE INVENTION CONCERNS THE PREPARATION OF RACEMIC OR OPTICALLY ACTIVE ALKYL-2-CHLORO-PROPIONATE, FROM RACEMIC OR OPTICALLY ACTIVE ALCOHOL LACTATE. THIS PROCESS CONSISTS, IN A FIRST STEP, IN GRADUALLY PUTTING IN CONTACT THE ALCOHYL LACTATE AND THIONYL CHLORIDE, IN THE PRESENCE OF AN EFFECTIVE QUANTITY OF AN ORGANIC BASE SUCH AS PYRIDINE, MAINTAINING AN EXCESS IN THE REACTIONAL MIXTURE MOLAR OF THIONYL CHLORIDE OF AT LEAST 2.5 IN RELATION TO THE AMOUNT OF ALCOHYL LACTATE INTRODUCED INTO THIS MIXTURE, AT A TEMPERATURE LOWER THAN THE DECOMPOSITION TEMPERATURE OF ALCOHYL ACTATE CHLOROSULFINATE AS INTERMEDIATE THEN THEN, , IN A SECOND STAGE, THE REACTIONAL MIXTURE RESULTING FROM THE FIRST STAGE IS HEATED TO A TEMPERATURE AT LEAST EQUAL TO THE DECOMPOSITION TEMPERATURE OF THE ALKYL ACTATE CHLOROSULFINATE. ALKYL-2-CHLORO PROPIONATES CAN BE USED FOR THE MANUFACTURE OF 2-PHENOXY-PROPIONIC, RACEMIC OR OPTICALLY ACTIVE ACIDS.

Process for obtaining the dizincic salt of oxymethane-sulfinic acid

Process for alpha-chlorination of sulfenyl halides

New fluorinated polymer products useful for the polymerization of fluorinated vinyl monomers such as e.g. tetrafluoroethylene, fluorinated vinylidene, hexafluoropropane and their copolymers

Fluorinated polymer products (I) and (II) are new. Fluorinated polymer products (I) and (II) of formulae Rf(CH2CF2)mSO2M and Rf(CH2CF2)m(CH2)naSO3M are new. Rf1-5C (preferably 2-4C) perfluoroalkyl; m : 3-6; na : 0 or 2; and M : H, alkaline metal or ammonium group or ammonium group comprising substituted lower alkyl.

Patent FR2442833B1

PROCESS FOR THE PURIFICATION OF TRIFLUOROMETHANESULFINATE AND SODIUM SULFONATE

La présente invention concerne un procédé de purification des trifluorométhanesulfinate et sulfonate de sodium à partir de son milieu de préparation qui consiste à extraire le diméthylformamide avec du dichlorométhane puis à éliminer l'eau par distillation azéotropique puis à extraire le trifluorométhanesulfinate par l'acétate d'éthyle et à évaporer cette solution. Le trifluorométhanesulfonate est obtenu par oxydation du trifluorométhanesulfinate à l'aide d'eau d'oxygénée ou par l'hypochlorite de sodium. The present invention relates to a process for the purification of trifluoromethanesulfinate and sodium sulphonate from its preparation medium which consists in extracting the dimethylformamide with dichloromethane then in removing the water by azeotropic distillation and then in extracting the trifluoromethanesulfinate with acetate d ' ethyl and evaporate this solution. Trifluoromethanesulfonate is obtained by oxidation of trifluoromethanesulfinate with oxygenated water or with sodium hypochlorite.

Synthetic method of pasiclovir intermediate

本发明公开了一种帕西洛韦(Paxlovid)中间体的合成方法，涉及化学药物中间体技术领域。包括如下步骤：3,3‑二甲基‑4‑氧代丁酸酯与S‑取代亚磺酰胺反应生成化合物C‑1；化合物C‑1和单卤素取代乙酸酯在强碱作用下反应，利用S‑取代亚磺酰胺手性诱导，得到化合物C‑2；化合物C‑2在强碱作用下形成过渡态中间体化合物C‑3，进一步在强碱作用下和S‑取代亚磺酰手性诱导下，生成化合物C‑4；化合物C‑4脱保护基得化合物C‑5；化合物C‑5经还原反应得帕西洛韦中间体。本发明的方法原料低价易得、能耗低、制备简单、安全性高且降低了因手性拆分导致的损失。

Patent FR2051718A1

Method of producing oxy-sulphonated and fluorine-containing organic derivatives

FIELD: chemistry. SUBSTANCE: present invention relates to an improved method of producing a salt of fluoroalkane sulphinic acid which can be used in chemical industry. The method involves conducting a reaction in the presence of an organic polar aprotic solvent of sulphur oxide with fluorocarboxylic acid, at least partially converted into a salt by a volumetric organic or mineral cation of the corresponding halofluoroacetic acid of formula (Ia): X-CF 2 -COOH (Ia), where X denotes a fluorine atom; of formula (Ib): R-G-CF 2 -COOH(Ib), where G denotes a perfluoroalkylene group -(CF 2 )n-, where n ranges from 1 to 10, R denotes a halogen atom, preferably chlorine or fluorine. EFFECT: novel efficient method of producing a salt of fluoroalkanesulphinic acid is provided. 21 cl, 6 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 471 776 (13) C2 (51) МПК C07C 313/04 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2008146510/04, 18.04.2007 (24) Дата начала отсчета срока действия патента: 18.04.2007 (72) Автор(ы): БЕССОН Бернар (FR), МЕТЦ Франсуа (FR) (73) Патентообладатель(и): РОДИА ОПЕРАСЬОН (FR) R U Приоритет(ы): (30) Конвенционный приоритет: 26.04.2006 FR 0603715 (43) Дата публикации заявки: 10.06.2010 Бюл. № 16 2 4 7 1 7 7 6 (45) Опубликовано: 10.01.2013 Бюл. № 1 (56) Список документов, цитированных в отчете о поиске: RU 2160252 C2, 10.12.2000. SU 1684277 A1, 15.10.1991. Jerry March, Advanced Organic Chemistry, 4 изд., John Wiley and Sons, 1992, глава 9, с.278-286. 2 4 7 1 7 7 6 R U (86) Заявка PCT: FR 2007/000649 (18.04.2007) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 26.11.2008 (87) Публикация заявки РСТ: WO 2007/128893 (15.11.2007) Адрес для переписки: 129090, Москва, ул.Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. А.В.Мицу, рег.№ 364 (54) СПОСОБ ПОЛУЧЕНИЯ ОКСИСУЛЬФИРОВАННЫХ И ФТОРСОДЕРЖАЩИХ ОРГАНИЧЕСКИХ ПРОИЗВОДНЫХ (57) Реферат: Настоящее ...

New reagent, useful for the prepn. of fluorinated and oxo-sulphurated derivs.

Reagent useful for the synthesis of oxosulphated and fluorinated organic derivs. by reaction with a sulphur oxide, esp. sulphur dioxide, comprises (a) a fluorocarboxylic acid of formula Ea-CF2-COOH (I) (Ea = electron withdrawing atom or group), in the form of a (partial) salt formed with an organic or mineral cation; and (b) a polar aprotic solvent. The mobile proton content of its components, including impurities, is at most equal to half the concn. of (I). Also claimed is the synthesis of only one fluorinated and oxysulphated organic cpd.comprising (a) reacting the above reagent with a sulphur oxide; and (b) heating the resulting mixt. at 100-200 deg C. for 0.5-10 hrs..

Patent FR2261761A1

Pesticidal treatment of stored goods, enclosures, structures and works of art, with sulphur compounds

The present invention is directed to the pesticidal treatment of stored foodstuffs, chambers, structures and works of art, using a volatile sulphur compound of general formula: in which R represents an alkyl or alkenyl radical containing from 1 to 4 carbon atoms, n is equal to 0, 1 or 2, x is a number ranging from 0 to 4, and R′ represents an alkyl or alkenyl radical containing from 1 to 4 carbon atoms or, only if n=x=0, a hydrogen atom. These sulphur compounds (in particular dimethyl disulphide) are applied by nebulization directly to the material to be treated.

PROCESS FOR THE SYNTHESIS OF OXYSULFIDE AND FLUORINATED ORGANIC DERIVATIVES

Process for the preparation of 4-alkylsulfonyl-1-alkyl-2-chlorobenzenes and the like

Process for the preparation of 4-alkylsulfonyl-1-alkyl-2-chlorobenzenes and like compounds. A process for the preparation of 4-alkyl(C1-C4)-sulfonyl-1-alkyl-2-chlorobenzenes, in very good yields and with high selectivity by selectively chlorinating a p-alkyl-benzenesulfonyl chloride with gaseous chlorine in the presence of a chlorine carrier at 50°C to 100°C to give a compound of the formula (see formula I) in which R1 is an alkyl(C1-C4) group, subsequently reducing the latter in an aqueous medium at a pH of 8 to 10 with alkali metal sulfate or alkali metal hydrogen sulfite, preferably sodium hydrogen sulfite or sodium sulfite, at 40 to 90°C to give a compound of the formula (see formula II) in which T represents an alkali metal, and reacting the latter with alkyl(C1-C4) chloride in the presence of an acid binder at 80 to 150°C, and also compounds of the last mentioned formula which, instead of the -SO2Na group contain she -SO2X group (X = hydrogen atom or alkali metal atom).

The method of obtaining trichloromethanesulfonyl chloride

Method for analyzing and preparing tert-butyl sulfinamide enantiomer by using HPLC

本申请公开了一种用HPLC分析及制备叔丁基亚磺酰胺对映异构体的方法，包括以下步骤：将含有(RS)‑叔丁基亚磺酰胺的样品用HPLC法进行分析和/或制备，采用正相色谱法；以硅胶表面涂覆纤维素衍生物作为手性固定相，以烷烃和低级醇及其酯的混合溶液作为流动相。解决了叔丁基亚磺酰胺对映异构体的分析分离问题，能够快速、准确和高效分析分离叔丁基亚磺酰胺对映异构体，有效控制叔丁基亚磺酰胺的质量，得到光学纯的叔丁基亚磺酰胺。

Production of perchloromethyl mercaptan

Abstract of the Disclosure A catalyst composition suitable for the production of perchloromethyl mercaptan comprising lead acetate, solvent impregnated, on magnesium silicate.

The use of certain sulphinic acids and their derivatives for the regulation of plant growth

Compositions of tetrahalo-ethyl-sulfenyl halides.

Process for the preparation of 1,2-benzisothiazolin-3-ones

Cyanobenzenesulfenyl halide and process for preparation of 3-substituted benzisothiazole using the same

The present invention provides a compound represented by the general formula (I): (see formula I) wherein X represents Cl or Br, a process for preparation of the same and a process for preparation of 3-substituted benzisothiazole by reaction of the compound (I) with a piperazine compound. The compounds of the present invention are useful as intermediates in the preparation of pharmaceuticals.

REPLACED UREAS AND PROCEDURE FOR THEIR PREPARATION

Purification of perchloromethyl mercaptan

1345637 Purification of CCl 3 .SH STAUFFER CHEMICAL CO 24 Jan 1972 [22 Feb 1971] 3179/72 Heading C2C Perchloromethyl mercaptan is purified by mixing thoroughly with water for a period of time sufficient to hydrolyse the sulphur monochloride (S 2 Cl 2 ) impurity but short enough to eliminate any significant hydrolysis (i.e. >5%) of the perchloromethyl mercaptan and thereafter separating from the mixture, by filtration, the purified product. The mixing time is preferably between 1 and 3 minutes using a volume ratio of perchloromethyl mercaptan to water of between 1À0 : 0À5 and 1À0 : 4À0. The purification is preferably carried out at 10‹ to 50‹ C. using perchloromethyl mercaptan of 85 to 96% purity.

Method for producing perfluoroalkanesulfinate

Trifluoromethanesulfinate purification method

本发明公开了一种三氟甲基亚磺酸提纯方法，包括混合搅拌三氟甲基亚磺酸钠工业品、无水硫酸镁及溶剂，搅拌抽滤，滤液收集，滤饼加回到原搅拌反应釜中，继续加入溶剂，搅拌抽滤，滤液收集，汇总所有过滤液及淋洗的滤液溶液并液置于釜中，减压蒸干，回收溶剂，加入去离子水，得三氟甲基亚磺酸钠水溶液；然后送干燥器进行喷雾干燥，得含量大于95％的三氟甲基亚磺酸钠粉末产品。本发明通过使用溶剂从三氟甲基亚磺酸钠工业品中萃取出高含量的三氟甲基亚磺酸钠，脱除溶剂后得到无溴离子等无机盐的高含量的三氟甲基亚磺酸钠，满足锂离子电池电解质双三氟甲烷磺酰亚胺锂生产要求。

N-sulfenyl-and n-sulfinyl-n,n'-diacylhydrazides

USE OF 2-HALOGENOETHANESULFIC ACIDS AND THEIR DERIVATIVES FOR REGULATING PLANT GROWTH

Process for the preparation of sulfinic and sulphonic acids or their salts

Preparation of ring-halogenated arylsulfenyl halides

PERCHLOROMETHYL MERCAPTAN PREPARATION PROCESS

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINATED DERIVATIVES BY SULFINATION

On décrit un procédé de préparation d'un dérivé oxysulfuré et fluoré comprenant la mise en réaction, en présence d'un solvant organique : i) d'au moins un composé de formule Ea-COOR (I), où Ea représente l'atome de fluor ou un groupe ayant de 1 à 10 atomes de carbone choisi parmi les fluoroalkyles, les perfluoroalkyles et les fluoroalkényles et R représente l'hydrogène, un cation monovalent ou un groupe alkyle, et ii) d'un oxyde de soufre, ledit procédé étant tel que le rapport molaire initial (oxyde de soufre/composé de formule (I)) est inférieur à 0,4 et la concentration en oxyde de soufre dissous dans le milieu réactionnel est maintenue constante durant toute la durée de la réaction à une valeur comprise entre 0,2 et 3% poids par un ajout continu dudit oxyde de soufre au milieu réactionnel. A process for preparing an oxysulfide and fluorinated derivative comprising reacting, in the presence of an organic solvent: i) at least one compound of formula Ea-COOR (I), wherein Ea represents the atom fluorine or a group having from 1 to 10 carbon atoms selected from fluoroalkyls, perfluoroalkyls and fluoroalkenyls and R represents hydrogen, a monovalent cation or an alkyl group, and ii) a sulfur oxide, said process being such that the initial molar ratio (sulfur oxide / compound of formula (I)) is less than 0.4 and the concentration of sulfur oxide dissolved in the reaction medium is kept constant throughout the reaction time at a value between 0.2 and 3% by weight by a continuous addition of said sulfur oxide to the reaction medium.

Heteroanthracycline antitumor analogs

Heterocyclic antitumor compounds are described, which are useful in the treatment of cancer and tumors in vitro, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, CNS cancer and melanoma. Pharmaceutical compositions and method of preparing the compounds are also described.

Method of producing optically active l-2-chlormethylpropionate

A racemic or optically active alkyl 2-chloropropionate is prepared, respectively, from a racemic or optically active alkyl lactate by, in a first step, gradually bringing the alkyl lactate into contact with the thionyl chloride, in the presence of an organic base, while maintaining, in the reaction mixture, an excess of thionyl chloride, relative to the amount of alkyl lactate introduced into this mixture, at a temperature below the decomposition point of the chlorosulphinate of the alkyl lactate, which is formed as an intermediate, and then, in a second step, in heating the reaction mixture resulting from the first step at a temperature which is at least equal to the decomposition point of the chlorosulphinate of the alkyl lactate. The alkyl 2-chloropropionates can be used for the manufacture of the racemic or optically active 2-phenoxypropionic acids.

Patent FR2032762A5

Patent FR2181113A5

Process for preparing oxysulphide and fluorinated compounds

Process for preparing trifluoromethylated carboxylic acids

Pentachloroethylsulphenyl chloride