12-07-2018 дата публикации
Номер: WO2018127236A1
Автор:
LI, Yi,
XIE, Huihui,
HUANG, Chaoming,
LI, Bo,
DING, Liang,
XIAO, Ying
Принадлежит:
Disclosed is a preparation method for (2S,3R,4S)-2,3,4,5-tetrahydroxy-valeraldehyde, which solves the problems in the prior art that reaction conditions are harsh, processes are complex, product yield is low, purity is not high, and industrialisation is difficult to implement. In the present invention, D-sorbitol is reacted with benzaldehyde in acidic conditions to produce 2,4-O-benzylidene-D-sorbitol, which is then reacted with an oxidizing agent to produce 2,4-O-benzylidene-L-xylose, which is then hydrolysed in acidic conditions to produce a (2S,3R,4S)-2,3,4,5-tetrahydroxy-valeraldehyde crude product, which is finally recrystallised to obtain (2S,3R,4S)-2,3,4,5-tetrahydroxy-valeraldehyde. The present invention has simple processes, easy operations, mild conditions, rapid reaction speeds, high product yield, high purity and low equipment investment, and is suitable for large-scale industrial production.
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