SULPHUR-CONTAINING AND SULPHONATED AROMATIC PERFLUOROALKANE MONOMER

A sulphur-containing and sulphonated aromatic perfluoroalkane monomer is provided that can be used for the manufacture of a polymer membrane for a PEM-type fuel cell. The perfluoroalkane monomer is a functionalized polymer that has a structure corresponding to a formula (I): 19-. (canceled)11. The monomer according to claim 10 , wherein n is in a range from 2 to 20.12. The monomer according to claim 10 , wherein n is in a range from 2 to 8.13. The monomer according to claim 10 , wherein Eand E claim 10 , which are identical or different claim 10 , are chosen from a group that includes: halogens claim 10 , carboxyls claim 10 , acyl chloride claim 10 , sulphonyl chloride claim 10 , sulphonyl fluoride claim 10 , isocyanate claim 10 , and combinations thereof.14. The monomer according to claim 13 , wherein Eand E claim 13 , which are identical or different claim 13 , represent halogens.15. The monomer according to claim 14 , wherein the monomer corresponds to a formula (II):{'br': None, 'sub': 1', '1', '2', 'n', '2', '2, 'F—Ar—X—(CF)—X—Ar—F\u2003\u2003(II).'}16. The monomer according to claim 14 , wherein the monomer corresponds to a formula (III):{'br': None, 'sub': 1', '1', '2', 'n', '2', '2, 'Cl—Ar—X—(CF)—X—Ar—Cl\u2003\u2003(III).'}17. The monomer according to claim 10 , wherein n is equal to 4.18. The monomer according to claim 11 , wherein n is equal to 4.19. The monomer according to claim 12 , wherein n is equal to 4.20. The monomer according to claim 13 , wherein n is equal to 4.21. The monomer according to claim 14 , wherein n is equal to 4.22. The monomer according to claim 15 , wherein n is equal to 4.23. The monomer according to claim 16 , wherein n is equal to 4. The present invention relates to the monomers which can be used for the synthesis of polymers intended in particular, in the sulphonated form, to constitute a solid electrolyte or membrane in a fuel cell.It relates more particularly to the above monomers of the aromatic type comprising a central ...

Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses

The invention provides electrophilic monohalomethylating reagents, methods for their preparation and methods for preparation of monohalomethylated biologically active compounds using such reagents. Typical monohalomethyl groups transferred are FH2C—, CIH2C— and others. The reagents used for transferal of the groups are described by Formulae A-D: wherein: X═F, CI, Br, I, sulfonate esters, phosphate esters or another leaving group; R11=tetrafluoroborates, inflates, halogen, perchlorate, sulfates, phosphates or carbonates The other variables are as defined in the claims. 2. A compound according to wherein for any of compounds A claim 1 , B claim 1 , C or D the said leaving group is the conjugated base of a strong acid or is a weak base.3. A compound of formula A according to claim 1 , wherein:X═F, Cl or Br; and{'sub': 1', '10, 'R1, R2, R3, R4, R5, R6, R7, R8, R9, R10=H or alkyl or C-Calkyl; and'}R11=tetrafluoroborate or triflato.4. A compound of formula A according to claim 3 , wherein:R1, R2, R3, R4, R5, R6, R7, R8, R9, R10=H or methyl.5. A compound of formula B according to claim 1 , wherein:X═F, Cl or Br; and{'sub': 1', '10, 'R1, R2, R3, R4, R5=H or alkyl or C-Calkyl; and'}R11=tetrafluoroborate or triflato; andR12=resin or naphthalene.6. A compound of formula B according to claim 5 , wherein:R1, R2, R3, R4, R5=H or methyl.7. A compound of formula C according to claim 1 , whereinX═F, Cl or Br; andR13=naphthalene; and{'sub': 1', '10, 'R6, R7, R8, R9, R10=H or alkyl or C-Calkyl; and'}R11=tetrafluoroborate or triflato.8. A compound of formula C according to claim 7 , whereinR6, R7, R8, R9, R10=H or methyl.9. A process for making an organic biologically active compound containing a “CHX” moiety claim 7 , or an intermediate therefor claim 7 , which process comprises the step of monohalomethylation claim 7 , wherein the monohalomethylating reagent used is a compound of formula A claim 7 , B claim 7 , C or D according to any one of to .10. A process according to wherein the ...

NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX

The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure. 1. (canceled)2. A method of treating a cardiovascular disease claim 35 , comprising administering an effective amount of the compound of to a patient in need thereof.3. The method of claim 2 , wherein the compound is administered intravenously.4. The method of claim 2 , wherein the cardiovascular disease is heart failure.5. The method of claim 4 , wherein the compound is administered intravenously.6. The method of claim 2 , wherein the cardiovascular disease is acute decompensated heart failure.7. The method of claim 6 , wherein the compound is administered intravenously.8. A pharmaceutical composition comprising the compound of and at least one pharmaceutically acceptable excipient.9. The pharmaceutical composition of claim 8 , wherein the pharmaceutical composition is suitable for intravenous administration.10. The pharmaceutical composition of claim 8 , wherein the at least one pharmaceutically acceptable excipient is at least one species of cyclodextrin.11. The pharmaceutical composition of claim 10 , wherein the pharmaceutical composition is suitable for intravenous administration.12. A method of treating a cardiovascular disease claim 8 , comprising administering an effective amount of the pharmaceutical composition of a patient in need thereof.13. The method of claim 12 , wherein the pharmaceutical composition is administered intravenously.14. The method of claim 12 , wherein the cardiovascular disease is heart failure.15. The method of claim 14 , wherein the pharmaceutical composition is administered intravenously.16. The method of claim 12 , wherein the cardiovascular disease is acute decompensated ...

CYANIDE ANTIDOTE COMPOSITIONS AND METHODS OF USE

Cyanide antidote compositions and methods of use are described herein. A cyanide antidote composition may include a sulfur analog, sulfur analog derivative, or a pharmaceutically acceptable derivative of a sulfur analog. 1. A cyanide antidote composition , comprising: {'br': None, 'sup': 1', '2, 'sub': 'n', 'R—S—R\u2003\u2003(I)'}, 'a sulfur analog, or pharmaceutically acceptable derivative of a sulfur analog, having the structure{'sup': 1', '3', '2', '4, 'sub': 2', '2, 'where Ris R—SO—; Ris R—SO; and n is 1 to 8;'}{'sup': '3', 'where Ris an alkyl moiety or an aryl moiety;'}{'sup': '4', 'where Ris an alkyl moiety or an aryl moiety.'}3. The cyanide antidote of claim 2 , wherein Rand Rcomprise aryl moieties and n is 1.4. The cyanide antidote of claim 2 , wherein Rand Rcomprise one or more substituted aryl moieties.5. The cyanide antidote of claim 1 , wherein Ris an allyl moiety and Ris an aryl moiety.9. The cyanide antidote of claim 1 , further comprising liposomes and/or dentrimeric polymers.10. The cyanide antidote of claim 1 , wherein the sulfur analog has the structure SR claim 1 , where Ris an alkyl moiety claim 1 , or aryl moiety and n is at least 3.12. A method of treating cyanide intoxication in a subject claim 1 , comprising: {'br': None, 'sup': 1', '2, 'sub': 'n', 'R—S—R\u2003\u2003(I)'}, 'administrating to a subject who would benefit from such treatment a therapeutically effective amount of a sulfur analog, or pharmaceutically acceptable derivative of a sulfur analog in an amount sufficient to convert at least some cyanide to thiocyanate to detoxify the subject, wherein the sulfur analog has the structure'}{'sup': 1', '3', '2', '4', '5, 'sub': 2', '2, 'where Ris S or R—SO—; Ris R—SO— or R; and n is 1 to 8;'}{'sup': 1', '3', '2', '4, 'sub': 2', '7, 'where Ris R—SO—; Ris R—SO; and n isl to 8;'}{'sup': '3', 'where Ris an alkyl moiety or an aryl moiety;'}{'sup': '4', 'where Ris an alkyl moiety or an aryl moiety.'}14. The method of claim 13 , wherein Rand ...

PROCESS FOR THE MANUFACTURE OF DIHALODIPHENYLSULFONES

A process for the preparation of dihalodiphenylsulfones such as 4,4′-dichlorodiphenyl sulfone or 4,4′-bis-(4-chlorophenylsulfonyl)biphenyl with high regioselectivity, at low temperature and in the absence of toxic reagents by reacting together at least one acid, at least one fluorinated anhydride and at least one halobenzene. The invented process is particularly suited for the manufacture of 4,4′-dichlorodiphenyl sulfone. 113-. (canceled)15. The process according to claim 14 , wherein the fluorinated acid is selected from the group consisting of perfluorinated alkane carboxylic acids claim 14 , perfluorinated alkane sulfonic acids claim 14 , and mixtures thereof.16. The process according to claim 14 , wherein the fluorinated acid is distilled off after the halobenzene is added to the reaction.17. The process according to claim 14 , wherein the molar ratio of the acid selected from the group consisting of sulfuric acid claim 14 , arene sulfonic acid claim 14 , or oleum to the halobenzene is from 0.2 to 5.18. The process according to claim 17 , wherein the molar ratio is from 0.4 to 2.19. The process according to claim 14 , wherein the process further comprises a catalyst selected from the group consisting of boric acid claim 14 , boronic acid claim 14 , aluminosilicates claim 14 , perfluoroalkanesulfonic acid resins claim 14 , mixed oxides claim 14 , and mixtures thereof. This application claims priority to U.S. provisional application No. 61/476,419 filed Apr. 18, 2011, the whole content of this application being incorporated herein by reference for all purposes.The present invention relates to a new process for the manufacture of dihalodiphenylsulfones such as 4,4′-dichlorodiphenyl sulfone.4,4′-Dichlorodiphenyl sulfone, abbreviated as DCDPS, is an organic sulfone with the formula (ClCH)SO. It is most commonly used as a key monomer in the manufacture of sulfone polymers.Other dihalodiphenylsulfones than 4,4′-dichlorodiphenyl sulfone and related derivatives are also ...

METHOD OF PURIFYING DIMETHYL SULFOXIDE

A method of purifying dimethyl sulfoxide economically and at good yield satisfies the specifications of the United States Pharmacopoeia and reduces odor. The method includes distilling a solution having 35 parts by weight or more of water admixed per 100 parts by weight of raw dimethyl sulfoxide. 17.-. (canceled)8. A method of purifying dimethyl sulfoxide comprising distilling a mixed solution prepared by adding 35 parts by weight or more of water to 100 parts by weight of raw dimethyl sulfoxide.9. The method as described in claim 8 , wherein the purified dimethyl sulfoxide has an absorbance of 0.01 to 0.20 at 275 nm.10. The method as described in claim 8 , wherein the water is ion-exchanged water claim 8 , distilled water claim 8 , ultrapure water claim 8 , or tap water.11. The method as described in claim 8 , wherein the water has an electrical conductivity of 50 mS/m or less at 25° C.12. The method as described in claim 8 , wherein the distillation is carried out in a single step to evaporate water to obtain dimethyl sulfoxide.13. The method as described in claim 8 , wherein the distillation is carried out in a first step to evaporate water to obtain roughly purified dimethyl sulfoxide claim 8 , followed by a second step of distilling the roughly purified dimethyl sulfoxide to obtain purified dimethyl sulfoxide.14. High-purity dimethyl sulfoxide obtained by a purification method as described in and having a purity of 99.996% or more as determined by gas chromatograph (GC) analysis.15. The method as described in claim 9 , wherein the water is ion-exchanged water claim 9 , distilled water claim 9 , ultrapure water claim 9 , or tap water.16. The method as described in claim 9 , wherein the water has an electrical conductivity of 50 mS/m or less at 25° C.17. The method as described in claim 10 , wherein the water has an electrical conductivity of 50 mS/m or less at 25° C.18. The method as described in claim 9 , wherein the distillation is carried out in a single step ...

ION PAIR CATALYSIS OF TUNGSTATE AND MOLYBDATE

The present invention relates to ion pair catalysts (I) comprising the cationic bisguanidinium ligand (A) and diperoxomolybdate anion (B). The present invention also relates to ion pair catalysts (III) comprising the cationic bisguanidinium ligand (C) and peroxotungstate anion (D). It further relates to the use of the said catalysts in the manufacture of enantiomerically enriched sulfoxides. 2. The complex of claim 1 , wherein:{'sub': 1', '1-3', '3, 'each Rindependently represents Calkyl-phenyl, which phenyl group is substituted by from two to four Rsubstituents;'}{'sub': 2', '4, 'each Rindependently represents phenyl, which group is unsubstituted or substituted by from one to two Rsubstituents;'}{'sub': 3', '4', '1-6', '3-6', '5, 'each Rand Rindependently represents fluoro, branched or unbranched Calkyl, Ccycloalkyl, which latter two groups are unsubstituted or substituted by one or more halogen atoms) or OR;'}{'sub': 1-3', '3-6, 'R5 represents branched or unbranched Calkyl or Ccycloalkyl, which groups are unsubstituted or substituted by one or more halogen atoms.'}3. (canceled)4. The complex of claim 1 , wherein the organic cation (A) is enantioenriched.5. The complex of claim 1 , where the organic cation (A) is selected from:(i) 1,4-bis((4S,5S)-1,3-bis(3,5-di-tert-butylbenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium;(ii) 1,4-bis((4R,5R)-1,3-bis(3,5-di-tert-butylbenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium;(iii) 1,4-bis((4S,5S)-1,3-bis(3,5-di-tert-butyl-4-methoxybenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium;(iv) 1,4-bis((4R,5R)-1,3-bis(3,5-di-tert-butyl-4-methoxybenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium;(v) 1,4-bis((4S,5S)-1,3-bis(3,5-di-tert-butyl-4-fluorobenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium; and(vi) 1,4-bis((4R,5R)-1,3-bis(3,5-di-tert-butyl-4-fluorobenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium.6. The complex of claim 5 , where the organic ...

COMPLEXES OF 1-METHYLCYCLOPROPENE WITH METAL COORDINATION POLYMER NETWORKS

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure. 1. An adsorption complex comprising 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN) , wherein the MCPN is a porous material , and the 1-MCP is adsorbed into the MCPN.2. The adsorption complex of claim 1 , wherein the MCPN has a mean pore diameter of 1 to 50 Å.3. The adsorption complex of claim 1 , wherein the MCPN is a magnesium coordination polymer network or a calcium coordination polymer network.4. The adsorption complex of claim 1 , wherein the MCPN comprises a metal node claim 1 , and wherein the metal node is Mg claim 1 , Mn claim 1 , Ca claim 1 , Cu claim 1 , Al claim 1 , Zn claim 1 , Fe claim 1 , or Co.5. The adsorption complex of claim 1 , wherein the MCPN is magnesium formate; [Ca(4 claim 1 ,4′-sulfonyldibenzoate).HO]; Cu-TDPAT (also referred to as 2 claim 1 ,4 claim 1 ,6-tris(3 claim 1 ,5-dicarboxylphenylamino)-1 claim 1 ,3 claim 1 ,5-triazine); Zn(tcbpe) (also referred to as the reaction product of tetra-(4-bromo-phenyl)ethylene (tpe-Br) and 4-(methoxycarbonyl)phenylboronic acid); [Co(biphenyldicarboxylate)4 claim 1 ,4′bipyridine].4DMF.HO; [Co(biphenyldicarboxy-late)(4 claim 1 ,4′bipyridine)]0.5DMF; [Zn(biphenyldicarboxylate)(1 claim 1 ,2-bipyridylethene)].2DMF claim 1 , Mg(CC—C—H—CO); aluminum terephthalate; Cu(benzene-1 claim 1 ,3 claim 1 ,5-tricarboxylate); Fe(1 claim 1 ,3 claim 1 ,5-benzenetricarboxylate); 2-methylimidazole zinc salt; Co(2-methylimidazole); or Al(OH)fumarate.6. The adsorption complex of claim 1 , wherein the MCPN is thermally stable at a ...

NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX

The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure. 2. A method of treating a cardiovascular disease claim 1 , comprising administering an effective amount of the compound of a patient in need thereof.3. The method of claim 2 , wherein the compound is administered intravenously.4. The method of claim 2 , wherein the cardiovascular disease is heart failure.5. The method of claim 4 , wherein the compound is administered intravenously.6. The method of claim 2 , wherein the cardiovascular disease is acute decompensated heart failure.7. The method of claim 6 , wherein the compound is administered intravenously.8. A pharmaceutical composition comprising the compound of and at least one pharmaceutically acceptable excipient.9. The pharmaceutical composition of claim 8 , wherein the pharmaceutical composition is suitable for intravenous administration.10. The pharmaceutical composition of claim 8 , wherein the at least one pharmaceutically acceptable excipient is at least one species of cyclodextrin.11. The pharmaceutical composition of claim 10 , wherein the pharmaceutical composition is suitable for intravenous administration.12. A method of treating a cardiovascular disease claim 8 , comprising administering an effective amount of the pharmaceutical composition of a patient in need thereof.13. The method of claim 12 , wherein the pharmaceutical composition is administered intravenously.14. The method of claim 12 , wherein the cardiovascular disease is heart failure.15. The method of claim 14 , wherein the pharmaceutical composition is administered intravenously.16. The method of claim 12 , wherein the cardiovascular disease is acute decompensated heart failure.17. ...

Compositions and methods for treating eye disorders

Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.

1-(2-ACYLOXYETHYL)CYCLOPROPYL SULFONATE COMPOUND, 3-HALOMETHYL-3-BUTENYL CARBOXYLATE COMPOUND, AND METHOD FOR PRODUCING 4-ALKYL-3-METHYLENEBUTYL CARBOXYLATE

Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically, provided is, for example, a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, comprising an acyloxylation step of subjecting a 1-(2-haloethyl)cyclopropyl sulfonate compound (1) to acyloxylation to obtain a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound (2), a halogenation step of subjecting the compound (2) to halogenation involving cyclopropyl-allyl rearrangement to obtain a 3-halomethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5). This application claims priority from Japanese Patent Application No. 2014-262613, filed Dec. 25, 2014, the disclosure of which is incorporated by reference herein in its entirety.The present invention relates to a method for producing a 4-alkyl-3-methylenebutyl carboxylate that is useful as a bioactive substance such as an insect pheromone and substance relating thereto and as a synthetic intermediate in organic synthetic chemistry. For example, the present invention relates to a method for producing 7-methyl-3-methylene-7-octenyl propionate, which is, for example, a major component of the sex pheromone of (Comstock) (generic name: San Jose Scale).The sex pheromones of insects are biologically active substances that are commonly secreted by female individuals and have the function of attracting male individuals. A small amount of the sex pheromone shows strong attractive activities. The sex pheromone has been widely used as means for forecasting insect emergence or for ascertaining regional spread (invasion into a specific area) and as means for controlling an insect pest. As the means for controlling insect pests, control methods called mass trapping, lure and kill (another name: ...

DISULFIDE BIOCONJUGATION

Compounds and methods are provided for one-step functionalization of disulfide bonds in proteins. 2. (canceled)5. The compound of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare independently selected from H claim 1 , alkyl claim 1 , or the payload or reactive moiety; and further wherein any of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and R claim 1 , together with the carbon atoms that separate them claim 1 , complete one or more rings.6. The compound of claim 1 , wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris the payload or reactive moiety.7. The compound of claim 1 , wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris coupled to the payload or reactive moiety.8. The compound of claim 1 , wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris arylsulfonyl or heteroarylsulfonyl claim 1 , such as phenylsulfonyl.9. The compound of claim 8 , wherein Ris the payload or reactive moiety claim 8 , and Ris phenylsulfonyl.10. The compound of claim 1 , wherein at least one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Ris halo.11. The compound of claim 10 , wherein Rand Rare F claim 10 , and Ris the payload or reactive moiety.12. The compound of claim 1 , wherein the payload or reactive moiety is a payload moiety.13. The compound of claim 12 , wherein the payload moiety is a drug moiety claim 12 , a detectable label claim 12 , or a PEG moiety.14. The compound of claim 13 , wherein the detectable label is a fluorophore claim 13 , a radiolabel claim 13 , or an imaging agent.15. The compound of claim 1 , wherein the payload or reactive moiety is a reactive moiety.16. The compound of claim 15 , wherein the reactive moiety is a hydroxyl claim 15 , haloacyl claim 15 , an alkene claim 15 , an alkyl halide claim 15 , an alkyne claim 15 , an amine claim 15 , an aryl azide claim 15 , an aryl halide claim 15 , ...

PROCESS FOR THE PRODUCTION OF ALKANESULFONIC ACIDS

The present invention deals with a process for the production of alkanesulfonic acids, in particular methanesulfonic acid, and a method of purification of the raw products. 1. A process for preparing an alkanesulfonic acid , the process comprising:reacting sulfur trioxide and an alkane to obtain a raw alkane sulfonic acid; andpurifying the raw alkane sulfonic acid in a distillation process comprising at least two steps, to obtain a purified alkanesulfonic acid.2. The process according to claim 1 , wherein the distillation process employs a distillation set-up comprising (i) one distillation column with high separation performance (main distillation) claim 1 , and (ii) at least one additional distillation column claim 1 , either before and/or after the main distillation column claim 1 , each with a separation performance not matching that of the main distillation column (pre-distillation and/or post-distillation claim 1 , respectively).3. The process according to claim 1 , wherein the alkanesulfonic acid is methanesulfonic acid (MSA) and the alkane is methane.4. The process according to claim 1 , wherein the distillation process is operated at a temperature in the range of 130° C. to 200° C. in all distillation columns.5. The process according to claim 1 , wherein the distillation process is operated at a pressure in the range of 0.1 to 30 mbar in all distillation columns.6. The process according to claim 1 , wherein the distillation process is performed in at least two separate distillation columns.7. The process according to claim 1 , wherein the distillation process consists of two or three separate distillation columns.8. The process according to claim 1 , wherein the distillation process occurs such that each distillation step is carried out in one column or in more than one column operated in parallel.9. The process according to claim 1 , wherein a first distillation step claim 1 , a third distillation step claim 1 , or both is performed in a reaction vessel ...

Thiol-based deep eutectic solvent

A deep eutectic solvent consisting of (2-hydroxyethyl) trimethyl ammonium chloride and dithiothreitol in a molar ratio of from 1:2 to 1:3 and from 0% to 10% co-solvent, and methods of enzymatic production of polypeptides using the deep eutectic solvent.

METHOD OF PREPARING VORTIOXETINE

The new method of preparing 1-(2-(2,4-di-methylphenylsulphanyl)pheny!)piperazine of formula (I) or its salt comprises a reaction of 2-(2,4-dimethylphenyl-sulphanyl)benzeneamine of formula (XI), wherein Me is methyl, with a suitable precursor of formation of piperazine ring of formula (X11), wherein LG is a leaving group and R is hydrogen or a protective group, in a suitable organic solvent, wherein the reaction is carried out without presence of a base in a neutral or acidic environment. 2. The method according to claim 1 , wherein the reaction is carried out without presence of a base in a neutral or acidic environment.3. The method according to claim 1 , wherein the leaving group LG is selected from the group consisting of Cl claim 1 , Br claim 1 , I claim 1 , methylsulfonyloxy claim 1 , toluenesulfonyloxy claim 1 , and the protective group is COOR′ claim 1 , wherein R′ is an unbranched or branched C1-C5 alkyl group.5. The method according to claim 1 , wherein the organic solvent is an aromatic solvent selected from the group consisting of chlorobenzene claim 1 , xylene claim 1 , toluene claim 1 , α claim 1 ,α claim 1 ,α-trifluorotoluene and their mixtures.6. The method according to claim 1 , comprising reacting 2-(2 claim 1 ,4-dimethylphenylsulphanyl)benzeneamine of formula XI with 1-1.2 equivalents of bis-(2-chloroethyl)amine hydrochloride of formula XIIaa in toluene at a temperature of 103-111° C.8. The method according to claim 7 , wherein the reduction of the nitro compound of formula X is carried out with metals selected from the group consisting of Fe claim 7 , Zn claim 7 , and Sn claim 7 , with metal salts claim 7 , or by catalytic hydrogenation or transfer-hydrogenation in the presence of a catalyst based on Pt claim 7 , Pd claim 7 , Ni claim 7 , Fe claim 7 , or Co in a suitable solvent selected from C1-C5 alcohols and esters.9. The method according to claim 8 , wherein the reduction of the nitro compound of formula X is carried out by hydrogenation on ...

ALKYL PHENYL SULFIDE DERIVATIVE AND PEST CONTROL AGENT

An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. 19-. (canceled)11. The alkyl phenyl sulfide derivative or an agriculturally acceptable salt thereof claim 10 , according to claim 10 , wherein R in the general formula [I′] is a 2 claim 10 ,2-difluoroethyl group claim 10 , a 2 claim 10 ,2 claim 10 ,2-trifluoroethyl group claim 10 , a 3 claim 10 ,3 claim 10 ,3-trifluoropropyl group claim 10 , a pentafluoroethyl group claim 10 , a 1 claim 10 ,2 claim 10 ,2 claim 10 ,2-tetrafluoroethyl group claim 10 , a 2-chloro-2 claim 10 ,2-difluoroethyl group claim 10 , a 2 claim 10 ,2 claim 10 ,3 claim 10 ,3-tetrafluoropropyl group claim 10 , a 2 claim 10 ,2 claim 10 ,3 claim 10 ,3 claim 10 ,3-pentafluoropropyl group claim 10 , a 3 claim 10 ,3-dichloroallyl group claim 10 , a propargyl group claim 10 , a cyclopropylmethyl group or a (2 claim 10 ,2-difluorocyclopropyl)methyl group.12. The alkyl phenyl sulfide derivative or an agriculturally acceptable salt thereof claim 10 , according to claim 10 , wherein R in the general formula [I′] is a halogen atom claim 10 , a C-Calkyl group claim 10 , a C-Chaloalkyl group or a cyano group.13. The alkyl phenyl sulfide derivative or an agriculturally acceptable salt thereof claim 10 , according to claim 10 , wherein Rin the general formula [I′] is a hydrogen atom claim 10 , a halogen atom or a C-Calkyl group.14. The alkyl phenyl sulfide derivative or an agriculturally acceptable salt thereof claim 11 , according to claim 11 , wherein R in the general formula [I′] is a halogen atom claim 11 , a C-Calkyl group claim 11 , a C-Chaloalkyl group or a cyano group.15. The alkyl phenyl sulfide derivative or an agriculturally acceptable salt thereof claim 11 , according to claim 11 , wherein Rin the general formula [I′] is a hydrogen atom claim 11 , a halogen atom or a C-Calkyl group.16. An alkyl ...

METHOD FOR AROMATIC FLUORINATION

Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SOFto a reaction mixture; reacting the SOFand the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where A is an aryl or heteroaryl; providing SOFto the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SOF, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F. 2. The fluorination method of claim 1 , wherein the solvent is selected from the group consisting of polar aprotic solvents claim 1 , alkoxy ether solvents claim 1 , nitrile solvents claim 1 , and aromatic solvents.3. The fluorination method of claim 1 , wherein the fluorinating reagent is selected from the group consisting of sodium fluoride claim 1 , potassium fluoride claim 1 , cesium fluoride claim 1 , lithium fluoride claim 1 , tetrabutylammonium fluoride claim 1 , and tetramethylammonium fluoride.5. The fluorination method of claim 4 , wherein the solvent is selected from the group consisting of polar aprotic solvents claim 4 , alkoxy ether solvents claim 4 , nitrile solvents claim 4 , and aromatic solvents.6. The fluorination method of claim 4 , wherein the cation is selected from the group consisting of claim 4 , sodium claim 4 , potassium claim 4 , cesium claim 4 , tetramethylammonium claim 4 , and tetrabutylammonium.7. A fluorination method comprising: 'where A is an aryl or heteroaryl;', 'providing a compound having the structure Ar—OH to a reaction mixture;'}{'sub': 2', '2, 'providing SOFto the reaction mixture;'} ...

Fluorosulfones

A foamable composition includes a blowing agent, a foamable polymer or a precursor composition thereof, and a nucleating agent. The nucleating agent includes a compound having structural formula (I) RSOR(SOR)(I) where R, R, and Rare each independently a fluoroalkyl group having from 1 to 10 carbon atoms that is linear, branched, or cyclic and optionally contain at least one catenated ether oxygen atom or a trivalent nitrogen atom, and n is 0 or 1. 1. A foamable composition comprising:a blowing agent;a foamable polymer or a precursor composition thereof; and {'br': None, 'sup': 1', '2', '3, 'sub': 2', '2', 'n, 'RSOR(SOR)\u2003\u2003(I)'}, 'a nucleating agent, wherein said nucleating agent comprises a compound having structural formula (I)'}{'sup': 1', '2', '3, 'where R, R, and Rare each independently a fluoroalkyl group having from 1 to 10 carbon atoms that is linear, branched, or cyclic and optionally contain at least one catenated ether oxygen atom or a trivalent nitrogen atom, and n is 0 or 1.'}2. (canceled)3. (canceled)4. The foamable composition according to wherein the blowing agent comprises an aliphatic hydrocarbon having from about 5 to about 7 carbon atoms claim 1 , a cycloaliphatic hydrocarbon having from about 5 to about 7 carbon atoms claim 1 , a hydrocarbon ester claim 1 , water claim 1 , or combinations thereof.5. (canceled)6. A foam made with the foamable composition according to .7. (canceled)8. A device comprising: {'br': None, 'sup': 1', '2', '3, 'sub': 2', '2', 'n, 'RSOR(SOR)\u2003\u2003(I)'}, 'a dielectric fluid comprising a compound having structural formula (I)'}{'sup': 1', '2', '3, 'where R, R, and Rare each independently a fluoroalkyl group having from 1 to 10 carbon atoms that is linear, branched, or cyclic and optionally contain at least one catenated ether oxygen atom or a trivalent nitrogen atom, and n is 0 or 1;'}wherein the device is an electrical device and wherein the dielectric fluid further comprises a second dielectric fluid, ...

SULFONE-CONTAINING POLYTHIOETHERS, COMPOSITIONS THEREOF, AND METHODS OF SYNTHESIS

Sulfone-containing polythioethers, compositions containing sulfone-containing polythioethers, methods of synthesizing sulfone-containing polythioethers and the use of sulfone-containing polythioethers in aerospace sealant applications are disclosed. The sulfone-containing polythioethers have sulfone groups incorporated into the backbone of the polythioether. Cured sealant compositions comprising the sulfone-containing polythioethers exhibit enhanced thermal resistance. 2. The polythioether of claim 1 , wherein the polythioether comprises a sulfone-containing polythioether adduct of Formula (3) claim 1 , a sulfone-containing polythioether adduct of Formula (3a) claim 1 , or a combination thereof:{'br': None, 'sup': 6', '6, 'sub': 2', '2', '2', '2', '2, 'R-A-[—CH—CH—S(O)—CH—CH-A-]N—R\u2003\u2003(3)'}{'br': None, 'sup': '6', 'sub': 2', '2', '2', '2', '2', 'z, '{R-A-CH—CH—S(O)—CH—CH-A-V′—}B\u2003\u2003(3a)'} N is an integer from 1 to 10;', {'sub': 'z', 'claim-text': z is an integer from 3 to 6;', 'each —V is a group comprising a terminal alkenyl group; and', 'each —V′— is derived from the reaction of —V with a thiol; and, 'B represents a core of a z-valent, alkenyl-terminated polyfunctionalizing agent B(—V)wherein, {'sup': '6', 'each Rindependently comprises hydrogen or a moiety having a terminal reactive group.'}], 'wherein'}4. The polythioether of claim 2 , wherein each Ris hydrogen.5. The polythioether of claim 2 , wherein each Ris the same and the reactive group comprises —SH claim 2 , —CH═CH claim 2 , —NH claim 2 , —OH claim 2 , an epoxy group claim 2 , a trialkylsilane group claim 2 , a silyl group claim 2 , —N═C═O claim 2 , or a Michael acceptor group.6. A thiol-terminated sulfone-containing polythioether comprising the reaction product of reactants comprising: [{'br': None, 'sup': 1', '2', '1, 'sub': 2', 'p', 'm', '2', '2', 'n, 'HS—R—[—S—(CH)—O—(R—O)—(CH)—S—R—]—SH\u2003\u2003(4)'}, {'br': None, 'sup': 1', '2', '1, 'sub': 2', 'p', 'm', '2', '2, '{HS—R-[—S—(CH)—O ...

PROCESS FOR THE PREPARATION OF OPTIONALLY SUBSTITUTED PHENYL AND PYRIDYL PYRROLIDINES

The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds. The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.It is known that certain aryl and heteroaryl pyrrolidines are useful for combating harmful pests such as insects, acari, helminthes and nematodes which occur in agriculture and in non-agriculture fields such as horticulture or in the field of veterinary medicine (cf. WO 2008/128711, WO 2010/124845, WO 2010/043315, WO 2011/080211).The present invention relates to a process for the preparation of compounds of formula (X)wherein Z, X, X, Xand Xand Q are as defined herein.The method according to the invention comprises the following steps:step (i): reacting trifluoroacetophenones of formula (II)with compounds of formula (III)T-CHS(O)R  (III)optionally in the presence of a solvent, in the presence of a base (e.g. potassium tert-butoxide) and optionally in the presence of an additive, to obtain compounds of formula (IV), which includes both isomers of formula E-(IV) and Z-(IV)Step (ii): reacting compounds of the formula (IV), E-(IV), or Z-(IV)which are converted into compounds of formula (I)by (step (iii-a)) heating compounds of formula (VI) in which m represents 1, optionally in the presence of a base (e.g. triethylamine or sodium carbonate), if appropriate in the presence of a solvent (e.g. toluene) (step (iii-a-1)), to obtain compounds of formula (VII)which are subjected to a catalytic hydrogenation (e.g. using gaseous hydrogen in the presence of platinum on charcoal in methanol and in the presence of formic acid), or to a reduction reaction using a hydride source (e.g. sodium borohydride) in an appropriate solvent (e.g. tetrahydrofuran) (step (iii-a-2)) ...

SYNTHETIC MATRIX FOR CONTROLLED CELL INGROWTH AND TISSUE REGENERATION

Biomaterials containing a three-dimensional polymeric network formed from the reaction of a composition containing at least a first synthetic precursor molecule having n nucleophilic groups and a second precursor molecule having m electrophilic groups wherein the sum of n+m is at least five and wherein the sum of the weights of the first and second precursor molecules is in a range from about 8 to about 16% b weight of the composition, preferably from about 10 to about 15%, more preferably from about 12 to about 14.5% by weight of the composition. In one embodiment, the first and second precursor molecules are polyethylene glycols functionalized with nucleophilic and electrophilic groups, respectively. In a preferred embodiment, the nucleophilic groups are amino and/or thiol groups and the electrophilic groups are conjugated, unsaturated groups. The ratio of the equivalent weights of the electrophilic groups (second precursor molecule) and the nucleophilic groups (first precursor molecule) is in the range of between 0.7 and 1.1, more preferably between 0.8 and 1.0. The first and/or second precursor molecule may be covalently bound to one or more molecules selected from the group consisting of cell adhesion peptides, growth factors, and growth factor-like peptides. 134-. (canceled)35. A kit comprising:i) a first molecule comprising a multifunctional polyethylene glycol comprising m electrophilic groups;ii) a second molecule comprising a multifunctional polyethylene glycol comprising n nucleophilic groups; andiii) a base solution,wherein n+m is at least 5, andwherein the sum of the weights of the first and second molecules is 8% to 16% by weight of the total weight of the combination of the first molecule, the second molecule, and the base solution.36. The kit of claim 35 , wherein the sum of the weights of the first and second molecules is 10% to 15% by weight of the total weight of the combination of the first molecule claim 35 , the second molecule claim 35 , and ...

CRYSTAL COMPOSITION (CC) COMPRISING 4,4′-DICHLORODIPHENYLSULFOXIDE CRYSTALS (C)

The invention relates to a crystal (C) consisting of at least 95% by weight of 4,4′-dichlorodiphenylsulfoxide, 0 to 2% by weight of impurities and 0 to 3% by weight of an organic solvent (os). Moreover, the present invention relates to a crystal composition (CC) comprising crystals (C) and a process for the production of the crystal composition (CC) and the crystal (C). 1: A crystal composition (CC) , comprising crystals (C) , wherein the crystals (C) consist of(a) at least 95% by weight of 4,4′-dichlorodiphenylsulfoxide,(b) 0 to 2% by weight of impurities, and(c) 0 to 3% by weight of an organic solvent (os),based on a total weight of the crystals (C) comprised in the crystal composition (CC), wherein the crystal composition (CC) has{'sub': '3', 'a d10,-value in a range of 100 to 400 μm,'}{'sub': '3', 'a d50,-value in a range of 300 to 800 μm and'}{'sub': '3', 'a d90,-value in a range of 700 to 1500 μm,'}{'sub': 3', '3', '3', '3, 'wherein the d10,-value is lower than the d50,-value and the d50,-value is lower than the d90,-value.'}2: The crystal composition (CC) of claim 1 , wherein the crystal composition (CC) comprises at least 95% by weight of the crystals (C) claim 1 , based on a total weight of the crystal composition (CC).3: The crystal composition (CC) of claim 1 , wherein the crystal composition (CC) has a bulk density in a range of 600 to 950 kg/m.4: The crystal composition (CC) of claim 1 , wherein an average aspect ratio of the crystals (C) is in a range of 0.2 to 1.5: The crystal composition (CC) of claim 1 , wherein an average sphericity of the crystals (C) is in a range of 0.75 to 0.85.6: The crystal composition (CC) of claim 1 , wherein a Hausner ratio is in a range of 1.05 to 1.27.7: The crystal composition (CC) of claim 1 , wherein a unit cell of the crystals (C) is monoclinic claim 1 , space group C 2/m claim 1 , cell lengths a=16.05 ű0.05 Å claim 1 , b=9.82 ű0.05 Å claim 1 , c=7.21 ű0.05 Å claim 1 , cell angles alpha 90°±0.1° claim 1 , beta 95. ...

METHOD OF DISTILLING DIMETHYL SULFOXIDE AND MULTISTAGE DISTILLATION TOWER

A method of distilling a liquid containing dimethyl sulfoxide using a distillation system, including mixing sodium carbonate with a liquid containing dimethyl sulfoxide at a bottom of the distillation system such that sodium carbonate accounts for 0.005% to 25% by weight relative to 100% by weight of the liquid containing dimethyl sulfoxide and sodium carbonate in total at the bottom of the distillation system and heating the bottom; and obtaining a distillate containing dimethyl sulfoxide at a position lower than a position at which the liquid containing dimethyl sulfoxide is introduced and higher than a position of the heating portion. 115.-. (canceled)16. A method of distilling a liquid containing dimethyl sulfoxide using a distillation system , comprising:(1) mixing sodium carbonate with a liquid containing dimethyl sulfoxide at a bottom of the distillation system such that sodium carbonate accounts for 0.005% to 25% by weight relative to 100% by weight of the liquid containing dimethyl sulfoxide and sodium carbonate in total at the bottom of the distillation system and heating the bottom; and(2) obtaining a distillate containing dimethyl sulfoxide at a position lower than a position at which the liquid containing dimethyl sulfoxide is introduced and higher than a position of the heating portion.17. The method according to claim 16 , wherein a distillate rich in dimethyl sulfoxide compared to a feed material supplied to the distillation equipment is obtained at the position lower than the position at which the liquid containing dimethyl sulfoxide is initially introduced and higher than the position of the heated portion.18. The method according to claim 16 , wherein the distillation system is a single multistage distillation tower.19. The method according to claim 16 , wherein the temperature of the bottom of the distillation system is 90° C. to 180° C.20. The method according to claim 16 , wherein sodium carbonate is directly added at the bottom of the ...

QUANTITATIVE DETECTION OF NON-FLUORINE ANTI-SOIL USING A FLUORESCENT TRACE INDICATOR

A method for quantitatively and indirectly measuring non-fluorine anti-soil chemistry in carpet applications, is based on a known amount of FI trace to be added along with anti-soil chemistry in formulation prior to application to a carpet surface. The anti-soil chemistry with the trace amount of FI is then applied to the carpet through a topical foam or spray applicator during a precoating process. After completion of the precoat process, a carpet sample is collected, carpet face fiber is shaved, and FI is extracted using water. The extracted water solution is used to measure the fluorescence intensity (in counts per second or “CPS”) using a Fluorimeter. 1. A method for quantitatively measuring the amount of a treatment composition present on a textile substrate , the method comprising the following steps , in order:(a) adding a predetermined amount of a fluorescent indicator (FI) to the treatment composition;(b) applying the treatment composition obtained from step (a) to the surface of the textile substrate,(c) taking a sample of the surface,(d) extracting the FI from a portion of the sample to obtain a solution containing FI,(e) measuring the fluorescence emission intensity in the solution and(f) comparing to a predetermined baseline to determine the concentration of FI.2. The method of claim 1 , wherein step (c) further comprises isolating a sample of the textile substrate and removing a portion of the surface from the sample.3. The method of claim 1 , wherein the treatment composition is a non-fluorine anti-soil composition.4. The method of claim 1 , wherein the textile substrate is a carpet.5. The method of claim 1 , wherein the textile substrate has an uneven and/or irregular surface onto which the treatment composition is applied.7. The method of claim 6 , wherein the FI is selected from the group consisting of 1 claim 6 ,5-Naphthalenedisulfonic acid disodium salt claim 6 , 1 claim 6 ,5-Naphthalenedisulfonic acid tetrahydrate claim 6 , 2 claim 6 ,6- ...

METHOD OF PURIFYING DIMETHYL SULFOXIDE

A method of purifying dimethyl sulfoxide includes distilling a dimethyl sulfoxide-containing liquid in the presence of sodium carbonate under a reduced pressure in an inert gas atmosphere to distill out dimethyl sulfoxide, an amount of the sodium carbonate with respect to 100 g of pure dimethyl sulfoxide in a residual liquid after the distillation being 6 times or more the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation. 1. A method of purifying dimethyl sulfoxide comprising distilling a dimethyl sulfoxide-containing liquid in the presence of sodium carbonate under reduced pressure in an inert gas atmosphere to distill out dimethyl sulfoxide , an amount of the sodium carbonate with respect to 100 g of pure dimethyl sulfoxide in a residual liquid after the distillation being 6 times or more the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation.2. The method according to claim 1 , wherein the distillation is performed by adding claim 1 , at a start of the distillation claim 1 , the sodium carbonate in an amount of 0.0005 to 1.0 g with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid.3. The method according to claim 1 , wherein the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the residual liquid after the distillation is 6 to 1000 times the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation.4. The method according to claim 1 , wherein the amount of the sodium carbonate in the residual liquid after the distillation is 0.01 to 100 g with respect to 100 g of the pure dimethyl sulfoxide in the residual liquid after the distillation.5. The method according to claim 1 , wherein claim 1 , ...

METHOD OF PURIFYING DIMETHYL SULFOXIDE

A method of purifying dimethyl sulfoxide includes distilling a dimethyl sulfoxide-containing liquid in the presence of sodium carbonate in an inert gas atmosphere to distill out dimethyl sulfoxide, an amount of the sodium carbonate with respect to 100 g of pure dimethyl sulfoxide in a residual liquid after the distillation being 6 times or more the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation. 17-. (canceled)8. A method of purifying dimethyl sulfoxide comprising distilling a dimethyl sulfoxide-containing liquid in the presence of sodium carbonate in an inert gas atmosphere to distill out dimethyl sulfoxide , an amount of the sodium carbonate with respect to 100 g of pure dimethyl sulfoxide in a residual liquid after the distillation being 6 times or more the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation.9. The method according to claim 8 , wherein the distillation is performed by adding claim 8 , at a start of the distillation claim 8 , the sodium carbonate in an amount of 0.0005 to 1.0 g with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid.10. The method according to claim 8 , wherein the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the residual liquid after the distillation is 6 to 1000 times the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation.11. The method according to claim 8 , wherein the amount of the sodium carbonate in the residual liquid after the distillation is 0.01 to 100 g with respect to 100 g of the pure dimethyl sulfoxide in the residual liquid after the distillation.12. The method according to claim 8 , wherein claim 8 , after water in the dimethyl ...

PROCESS FOR PRODUCING SULFONIC ACID

The subject of the present invention is a process for producing a sulfonic acid which is sparingly corrosive, or even non-corrosive, with respect to stainless steels, said process comprising at least the steps of adding at least one nitrite to a sulfonic acid, curing, with stirring, with sparging of the mixture and recovering the low-corrosion sulfonic acid obtained. 1. Process for producing a low-corrosion sulfonic acid , comprising at least the following steps:a) adding at least one nitrite to a conventional sulfonic acid;b) curing the mixture obtained in step a) at a temperature between 0° C. and 100° C., and preferably between 0° C. and 80° C., more particularly between 10° C. and 60° C., even more particularly between 10° C. and 50° C., for a period of between a few seconds and a few hours, preferably between 1 min and 4 h, more particularly between 10 min and 2 h, even more particularly between 10 min and 1 h;c) recovering the low-corrosion sulfonic acid,2. Process according to claim 1 , in which the nitrite is chosen from alkali metal nitrites claim 1 , alkaline-earth metal nitrites and ammonium nitrite claim 1 , preferably from sodium nitrite and potassium nitrite claim 1 , more preferably the nitrite is sodium nitrite.3. Process according to or claim 1 , in which the sulfonic acid is a sulfonic acid of formula R—SOH claim 1 , where R represents a linear claim 1 , branched or cyclic claim 1 , saturated or unsaturated hydrocarbon-based chain comprising from 1 to 12 carbon atoms claim 1 , which is unsubstituted or substituted with one or more radicals and/or atoms chosen from halogen atoms claim 1 , alkyl radicals containing from 1 to 6 carbon atoms and aryl and heteroaryl radicals comprising 6 or 10 ring members.4. Process according to claim 1 , in which the sulfonic acid is chosen from methanesulfonic acid claim 1 , ethanesulfonic acid claim 1 , n-propanesulfonic acid claim 1 , iso-propanesulfonic acid claim 1 , n-butanesulfonic acid claim 1 , iso- ...

Process for preparing optically active alcohol

A β-keto acid derivative (1 mol) of formula (II): where R¹ is optionally substituted C1-7 alkyl, trifluoro­methyl or aryl, R² is C1-8 alkoxy, SR⁵ where R⁵ is C1-8 alkyl or phenyl or -NR⁶R⁷ where R⁶ and R⁷ are H, C1-8 alkyl or benzyl, and R³ is H, halogen, C1-8 alkyl or alkoxycarbonyl of R¹+R³ form a methylene chain, is dissolved in a solvent and there is added 100-1/50,000 mol of a ruthenium-optically active phosphine derivative as catalyst, e.g. of formula Ru x H y Cl z (R⁸-BINAP)₂(S) p (III) or [RuH l (R⁸-BINAP) v ]Y w (V) wherein BINAP is a specified tertiary phosphine group. The derivative is reacted with hydrogen at a pressure of 5-100 kg/cm2 for 1-48 hours and there is recovered as product an optically active alcohol of the formula (I) wherein the =C=O group has become CH-OH.

Phosphorus-sulfur fr additives and polymer systems containing same

Phosphorus-sulfur compounds have flame retardant activity in organic polymer systems. The phosphorus-sulfur compounds can be represented by the structure: Formula (I) wherein X is oxygen or sulfur, T is a covalent bond, oxygen, sulfur or nitrogen, provided that at least one of X and T is sulfur, each X' is independently oxygen or sulfur, each m is independently zero or 1 when X' is oxygen and zero, 1 or 2 when X' is sulfur, n is at least 1 and preferably at least 2, each R is independently an unsubstituted or inertly substituted hydrocarbyl group or the R groups together form an unsubstituted or inertly substituted divalent organic group and A is an organic linking group.

Phosphorus-sulfur flame retardant additives and polymer systems containing same

Phosphorus-sulfur compounds have flame retardant activity in organic polymer systems. The phosphorus-sulfur compounds can be represented by the structure: wherein X is oxygen or sulfur, T is a covalent bond, oxygen, sulfur or nitrogen, provided that at least one of X and T is sulfur, each X' is independently oxygen or sulfur, each m is independently zero or 1 when X' is oxygen and zero, 1 or 2 when X' is sulfur, n is at least 1 and preferably at least 2, each R is independently an unsubstituted or inertly substituted hydrocarbyl group or the R groups together form an unsubstituted or inertly substituted divalent organic group and A is an organic linking group.

Process for the production of 4,4'-dichlorodiphenyl sulfone

A method for the preparation of polymer grade 4,4'-dichlorodiphenyl sulfone (DCDPS) which is substantially free of 2,4' and 3,4'-isomers of dichlorodiphenyl sulfone with yield of over 90%, with substantially reduced reaction times without the use of impregnated catalysts. Furthermore, the reactants and byproducts are substantially recycled. The process involves reacting dimethyl sulfate with sulfur trioxide, reacting the formed dimethyl pyrosulfate with unreacted sulfur trioxide, reacting the mixture with monochlorobenzene, isolating the crude DCDPS using solvent extraction, recovering the solvent from the mother liquor and crystallizing the pure DCDPS. In another aspect, a process in which isomeric mixture of 4,4'-, and 2,4'-dichlorodiphenyl sulfone produced during the preparation of DCDPS is converted to value added products such as diphenyl sulfone, 2,4'- dihydroxydiphenyl sulfone, 4,4'-dihydroxydiphenyl sulfone and 2-aminodiphenyl sulfone.

[UNK]

Process for preparing aryl trifluoromethylsulfides

Trifluoromethylthiocopper, formed in situ by the reaction of bis-(trifluoromethylthio)mercury with copper, reacts with aromatic bromides and iodides to give aryl trifluoromethyl sulfides.

Insecticidal pyrazoline derivatives

ベンゾイル尿素誘導体、その製造法及び殺虫剤

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Alkyl esters of 4-substituted phenoxyisobutyric acid

ALKYL ESTERS OF 4-SUBSTITUTED PHENOXYISOBUTYRIC ACID WHICH ARE USEFUL IN THE TREATMENT OF HYPOCHOLESTEROLEMIA IN MAMMALS AND AS PREVENTIVES OF BILIARY LITHIASIS IN MAMMALS.

Methods of treating cholesterolemia

THE METHODS OF THIS INVENTION ARE USEFUL FOR THE TREATMENT OF CHOLESTEROLEMINA IN MAMMALS. THE METHODS INVOLVE ADMINISTERING TO MAMMALS CERTAIN FLUORINATED DERIVATIVES OF ESTERS OF PHENOXY ISOBUTYRIC ACID.

(C)CRYSTAL COMPOSITION (CC) COMPRISING 4,4'-DICHLORODIPHENYLSULFONE CRYSTALS (C)

The invention relates to crystals (C) consisting of at least 98% by weight of 4,4′-dichlorodiphenylsulfone, 0 to 2% by weight of impurities and 0 to 2% by weight of at least one solvent (c). Moreover, the present invention relates to a crystal composition (CC) comprising crystals (C) and a process for the production of the crystal composition (CC) and the crystals (C). 115.-. (canceled)16. A crystal composition (CC) comprising crystals (C) , wherein the crystals (C) consist of(a) at least 99.95% by weight of 4,4′-dichlorodiphenylsulfone,(b) 0 to 0.05% by weight of impurities, and(c) 0 to 0.05% by weight of at least one solvent,{'sup': '3', 'based on the total weight of the crystals (C) contained in the crystal composition (CC), wherein the crystal composition (CC) has a bulk density determined according to EN ISO 60:2000-01 in the range of 570 to 750 kg/m.'}17. The crystal composition (CC) according to claim 16 , wherein the crystal composition (CC) comprises at least 95% by weight of crystals (C) claim 16 , based on the total weight of the crystal composition (CC).18. The crystal composition (CC) according to claim 16 , wherein the tapered density determined according to DIN ISO 787 part 11 of the crystal composition (CC) is in the range of 750 to 850 kg/m.19. The crystal composition (CC) according to claim 16 , wherein the Hausner ratio of the crystal composition (CC) is in the range of 1.05 to 1.25.20. The crystal composition (CC) according to claim 16 , wherein the flowability (ff) according to Jenike of the crystal composition (CC) is in the range of 10 to 50.21. The crystal composition (CC) according to claim 16 , wherein the average aspect ratio of the crystals (C) contained in the crystal composition (CC) is in the range of 0.2 to 1.22. The crystal composition (CC) according to claim 16 , wherein the average sphericity (SPHT) of the crystals (C) contained in the crystal composition (CC) is in the range of 0.6 to 0.9.23. The crystal composition (CC) according ...

Lubricating oil additives

1404714 Fuels; lubricants EXXON RESEARCH & ENG CO 7 Sept 1973 [15 Jan 1973] 1980/73 Headings C5F and C5G [Also in Division C2] A lubricating oil or fuel oil composition comprises a lubricating oil or a fuel oil and a sulphurized hydrocarbon-substituted phenol prepared by reacting a phenol of the formula wherein R is an aliphatic group, and m and n are integers from 1 to 5 provided m + n is not more than 6, with S in the presence of an organic amine having a pK 6 of between 2 and 12. Specified aliphatic groups R are alkyl, cycloalkyl and alkenyl groups. The fuel oil may be gasoline or diesel fuel. The lubricating oil may be animal, vegetable, mineral or synthetic ester lubricating oil. Other additives which may be present are dispersants, VI improvers, corrosion inhibitors or additional antioxidants.

Polysulfone compositions and derivatives thereof

The compositions disclosed herein comprise compounds of the formula: DOOCArO-ArSO.sub.2 Ar'QAr'SO.sub.2 Ar-OArCOOD (I) and also derivatives and polymers therefrom or from the compound: X-ArSO.sub.2 Ar'QAr'SO.sub.2 Ar-X in which compounds D is hydrogen, halogen or a monovalent hydrocarbon radical, preferably of 1-20 carbon atoms; Q is either --O-- or --SO 2 --; Ar and Ar' are divalent aromatic groups including a multiplicity of aromatic groups linked by O, SO 2 , hydrocarbon groups, etc.; and X is preferably Cl but may be other halogen atoms. In these compounds, the central core or residue --ArSO 2 Ar'QAr'SO 2 Ar-- may be represented by A. Various derivatives and polymers having the core A are prepared, such as diamides of the formula R 2 NOCArO-A-OArCONR 2 ; polyester polymers of the formula [--OROOCArO-A-OArCO--]; polyarylate polymers of the formula [--ArCOOArO-A-OArOOCArCOO--]; polycarbonate polymers of the formula [--OCOOArO-A-OArOOCO--]; phenolic resins, and many other derivatives. These compositions exhibit many desirable properties and have many uses including the improvement or upgrading of polyethylene terephthalate (PET) and polybutyleneterephthalate (PBT) resins when blended therewith.

Acides indenyl-acetiques et procede pour les

Phosphorus-sulfur fr additives and polymer systems containing same

Phosphorus-sulfur compounds have flame retardant activity in organic polymer systems. The phosphorus-sulfur compounds can be represented by the structure: Formula (I) wherein X is oxygen or sulfur, T is a covalent bond, oxygen, sulfur or nitrogen, provided that at least one of X and T is sulfur, each X' is independently oxygen or sulfur, each m is independently zero or 1 when X' is oxygen and zero, 1 or 2 when X' is sulfur, n is at least 1 and preferably at least 2, each R is independently an unsubstituted or inertly substituted hydrocarbyl group or the R groups together form an unsubstituted or inertly substituted divalent organic group and A is an organic linking group.

1-(.beta.-(R-THIO) PHENETHYL) IMIDAZOLES AND DERIVATIVES THEREOF

ABSTRACT OF THE DISCLOSURE Novel 1-[.beta.-(R-thio)phenethyl]imidazoles and the corresponding 1-[.beta.-(R-sulfinyl)phenethyl]imidazoles and 1-[.beta.-(R-sulfonyl)pbenethyl]?zoles of the formula:

Dialkylphenol sulphides

Chemical process, etc.

Mineral oil composition

A MINERAL OIL COMPOSITION COMPRISING A NEUTRAL, NONVOLATILE, MINERAL OIL BASE AND, AS A VISCOSITY INDEX IMPROVER, AN EFFECTIVE AMOUNT, FOR EXAMPLE, 0.5-3 WEIGHT PERCENT, OF AN ESSENTIALLY AMORPHOUS, OIL SOLUBLE COPOLYMER HAVING RANDOM REPEAT UNITS DERIVED, ON A WEIGHT BASIS WITH THE COMBINED WEIGHTS TOTALLING 100%, (A) 25-55% FROM ETHYLENE, (B) 37-75% FROM A TERMINALLY UNSATURATED STRAIGHT CHAIN MONOOLEFIN HAVING 3-12 CARBON ATOMS, (C) 0.1-10% FROM A NON-CONJUGATED DIOLEFIN HAVING 518 CARBON ATOMS AND ONLY ONE POLYMERIZABLE DOUBLE BOND, AND (D) 0.1-2% FROM A NON-CONJUGATED DIOLEFIN HAVING 518 CARBON ATOMS AND TWO POLYMERIZABLE DOUBLE BONDS, SAID COPOLYMER HAVING AN INHERENT VISCOSITY OF 0.7-1.8 AS MEASURED ON A 0.1 WEIGHT PERCENT SOLUTION IN TETRACHLOROETHYLENE AT 30*C. AND A WALLACE PLASTICITY OF AT LEAST 16, SAID COPOLYMER FURTHER CHARACTERIZED AS EXHIBITING SUPERIOR PROCESSABILITY AND ISOLABILITY AND GOOD SHEAR STABILITY.

Method for preparing 3-methyl mercaptopropionic aldehyde

(threo)-1-aryl-2-acylamido-3-fluoro-1-propanols and its preparation

내용 없음. No content.

Method of preparation of symmetric oxythioalcanes

Cyclopropane derivative and insecticidal and tickicidal composition containing it

Herbicidal compounds, compositions, and method of use

Novel and highly effective herbicidal compounds in the diphenylether class are provided herein.

파라-하이드로퀴논 유도체의 제조방법

본 발명은 항산화 및 심장기능 강화 등의 활성을 보유하여 화장품, 의약 및 건강보조식품 등의 원료로 광범위하게 사용되는 코엔자임 Q10의 제조를 위한 중간체인 하기 화학식 1의 파라-하이드로퀴논 유도체를 제조하는 방법에 관한 것이다. (화학식 1) 상기식에서, R은 C 1 내지 C 4 알킬을 나타내고, R 1 은 메틸 그룹에 의해 치환되거나 비치환된 탄소수 6개의 방향족 탄화수소를 나타낸다. 코엔자임 Q10, 파라-하이드로퀴논 유도체

피라졸린 유도체의 제법

내용 없음

아렌설포닉 에시드로부터 아렌설포닐 클로라이드를 얻는 새로운 방법

본 발명은 정밀화학 분야의 핵심적 중간체들의 합성과정에서 관능기 들의 변환에 중요한 역할을 하는 아릴설포닐 클로라이드의 새로운 제조 방법에 관한 것으로, 이전의 기술들이 아릴설포닉 에시드로 부터 아릴설포닐 클로라이드를 제조하는 방법으로 제시했던 섭시 70도 이상의 고온 반응과 긴 반응시간 및 균일하지 못한 반응조건 등의 문제점들을 해결하기 위해 아릴설포닉 에시드를 비스(트리클로로메틸)카보네이트 와 제삼인산칼륨 및 촉매량의 트리에틸아민과 섭시25도 이하의 온화한 조건에서 반응시킴을 특징으로 하는 아릴설포닐 클로라이드를 고수율로 얻는 새로운 방법을 제공함으로써 염료, 농약, 의약 및 전자재료등 관련 산업분야의 발전에 크게 기여할 것이다.

The method of producing dimethyl sulfoxide

Method of obtaining sulfone

Method of producing polymerization catalyst

Method for producing isoprene sulfones

Process for the manufacture of dihalodiphenylsulfones starting from organic acids

A process for the preparation of dihalodiphenylsulfones such as 4,4′-dichlorodiphenyl sulfone or 4,4′-bis-(4-chlorophenylsulfonyl)biphenyl with high regioselectivity, at low temperature and in the absence of toxic reagents by reacting together at least one acid, sulfur trioxide and at least one halobenzene. The invented process is particularly suited for the manufacture of 4,4′-dichlorodiphenyl sulfone.

Functional fluid containing metal salts of esters of hydrocarbyl succinic acid or anhydride with thio-bis-alkanols as antioxidants

There are disclosed zinc and nickel salts of mono- or di- esters of C 12 -C 50 aliphatic hydrocarbon substituted succinic acids or anhydrides, such as octadecenyl succinic anhydride, with thio-bis-alkanols such as dithiodiethanol. The products are useful as antioxidants for lubricating oils and functional fluids, especially automatic transmission fluids.

Carbocyclic six-membered ring compounds

Sechsringverbindungen der Formel I worin A ein Benzol- oder Cyclohexanring ist, X' bis X 6 jeweils unabhängig voneinander H, -OR, -COOR, -SR, -SOR, -SO 2 R oder, falls A eine Cyclohexanring ist, auch -O-COR, bedeuten, und R jeweils eine Alkylgruppe mit bis zu 15 C-Atomen, worin eine oder zwei CH 2 -Gruppen durch 0-Atome ersetzt sein können, ist. wobei mindestens drei der Substituenten X' bis X 6 von H verschieden sind. können als Bestandteile von diskotischen flüssigkristallinen Phasen für Flüssigkristall-Anzeigeelemente verwendet werden. Six-ring compounds of the formula I. wherein A is a benzene or cyclohexane ring, X 'to X 6 each independently of one another denote H, -OR, -COOR, -SR, -SOR, -SO 2 R or, if A is a cyclohexane ring, also -O-COR, and R is in each case an alkyl group with up to 15 C atoms, in which one or two CH 2 groups can be replaced by 0 atoms. with at least three of the substituents X 'to X 6 are different from H. can be used as components of discotic liquid crystalline phases for liquid crystal display elements.

Condensation polymers containing methine ultraviolet radiation-absorbing residues and shaped articles produced therefrom

A composition useful for molding into articles such as food containers, soft drink bottles, cured structural plastics and the like, comprising molding grade linear or unsaturated polyester or polycarbonate having reacted or copolymerized therein a total of from 100 to about 800 ppm, of the residue of one or a mixture of methine reactants of the formula ##STR1## wherein R 1 is hydrogen or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl or aryl radical; A 1 is an unsubstituted or substituted phenylene radical; A 2 is an unsubstituted or substituted 1,4-phenylene radical; R 2 is hydrogen or an unsubstituted or substituted alkyl, cycloalkyl or aryl radical; R 3 is cyano or ##STR2## and R 4 is one of the substituents which R 3 can represent or an unsubstituted or substituted carbamoyl, alkanoyl, aroyl, alkylsulfonyl, arylsulfonyl, aryl or aromatic heterocyclic radicals. The methine residues are present in the polymer as an integral part of the polymer chain and absorb ultraviolet radiation in the range of about 250 to about 390 nm. The residues are non-extractable from the polymer and stable at the conditions at which the polymers are manufactured and processed.

Insecticide-acaricide

Patent JPS5910344B2

Method of producing beta-methylthiopropionic aldehyde

Esters of trisubstituted hydroxyphenylalkonoic acids

6-SULFOXYPHENOL DERIVATIVES THEIR PREPARATION AND THEIR USE AS CYTOPROTEKTIVA

Benzoate derivative, its preparation, and use of said derivative

Novel surfactant polypod compound and its manufacture

Fire-retardant phosphorus-sulphur additives and polymer systems containing same

FIELD: chemistry. SUBSTANCE: present invention relates to phosphorus-sulphur compounds with fire-retardant properties, of formula: , where X denotes oxygen, T denotes sulphur, each X' independently denotes oxygen or sulphur, n is the valence of A and equals at least 2, A denotes an organic binding group, as well as a method of producing a foamed polymer, which involves formation of a molten mixture of a combustible thermoplastic or thermosetting polymer, at least one foaming agent and said phosphorus-sulphur compound under pressure, and then extruding the molten mixture through a nozzle in a region of low pressure such that the molten mixture expands and cools to form a foamed polymer. EFFECT: novel phosphorus-sulphur compound which is effective as a fire-retardant additive and a novel efficient method of producing foamed polymers with improved properties. 4 cl, 38 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 522 433 C2 (51) МПК C07F 9/165 (2006.01) C07F 9/173 (2006.01) C07F 9/177 (2006.01) C08K 5/5398 (2006.01) C08J 9/00 (2006.01) C08L 101/12 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012141581/04, 28.09.2012 (24) Дата начала отсчета срока действия патента: 05.12.2007 Приоритет(ы): (30) Конвенционный приоритет: 2009128050 21.12.2006 (45) Опубликовано: 10.07.2014 Бюл. № 19 2 5 2 2 4 3 3 R U A, 15.11.1978. US4388431 A, 14.06.1983. GB2206590 A, 11.01.1989. US4160795 A, 10.07.1979. Химическая энциклопедия под ред. И.Л. Кнунянца, "Большая Российская Энциклопедия", Москва, 1992, т. 3, стр.455456 и т. 4, стр. 7-8. EP0207380 A, 7.01.1987. US3341624 A, 12.09.1967. US4593058 A, 03.06.1986. EP0779332 A, 18.06.1997 (73) Патентообладатель(и): ДАУ ГЛОБАЛ ТЕКНОЛОДЖИЗ ЭлЭлСи (US) Адрес для переписки: 129090, Москва, ул. Большая Спасская, 25, стр. 3, ООО "Юридическая фирма "Городисский и Партнеры" (54) ФОСФОРНО-СЕРНЫЕ ОГНЕЗАЩИТНЫЕ ДОБАВКИ И ПОЛИМЕРНЫЕ СИСТЕМЫ, СОДЕРЖАЩИЕ ИХ (57) Реферат: Настоящее ...

Method of fighting undesirable plants

Compounds of the formula <CHEM> wherein R1 is halogen, CF3, alkoxy, alkyl, NO2, carboxylic or sulfonate ester, sulfonamide or CH2L; L is sulfonamide, alkoxy or ester; R2 is H, halogen, CE3 or OCH3; R9 is H or CH3; R9 is H or alkyl; R3 is <CHEM> W is O or S; Z is CH or N; X, Y X1, X2, X3, Y1 are selected from various organic, halo or amino substituents, or X1 may be H; and their agriculturally suitable salts, exhibit herbicidal and plant growth regulant activity. The compounds may be formulated for use in conventional manner. The compounds may be made by reacting a novel sulfonyl isocyanate of formula <CHEM> with an appropriate aminoheterocycle R3NHR8, R1, R2, R3, R8 and R9 being as defined above. Alternatively the appropriately substituted phenyl-methane sulfonamide may be reacted with an isothiocyanate R3NCS.

Method for preparing o, o-dialkyl-o- (2,2dichlorovinyl) -ionophosphates

The method of producing dibenzoxazepines

Phenoxyalkylcarboxylic acid derivatives and process for their preparations

Phenoxyalkylcarboxylic acid derivatives of the following formula, ##STR1## wherein R 1 indicates hydrogen atom, methyl group or ethyl group, m is an integer from 2 to 5, and n is an integer from 3 to 8, X 1 and X 2 each independently represent sulfur atom, oxygen atom, sulfinyl group or sulfonyl group, proviso X 1 and X 2 are not simultaneously oxygen atom; their alkali salts and hydrates thereof are useful as antiallergic agents.

Method of producing aryl-sulphur pentafluorides

FIELD: chemistry. SUBSTANCE: invention relates to novel methods of producing aryl-sulphur pentafluorides of formula (I) where: R 1 , R 2 , R 3 , R 4 and R 5 each independently denotes a hydrogen atom, a halogen atom, an unsubstituted alkyl group having 1-18 carbon atoms or a nitro group; R denotes a hydrogen atom or a halogen atom; M denotes an alkali metal atom; and X denotes a chlorine atom, a bromine atom or an iodine atom. The methods involve reaction of at least one aryl-sulphur compound with a halogen and a fluorine salt to obtain aryl-sulphur halotetrafluoride. The aryl-sulphur halotetrafluoride reacts with a fluoride source to obtain the desired aryl-sulphur pentafluoride. EFFECT: improved method. 21 cl, 3 tbl, 34 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 472 779 (13) C2 (51) МПК C07C 381/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2009139003/04, 21.03.2008 (24) Дата начала отсчета срока действия патента: 21.03.2008 (73) Патентообладатель(и): УБЭ Индастриз, Лтд. (JP) R U Приоритет(ы): (30) Конвенционный приоритет: 23.03.2007 US 60/896,669 (72) Автор(ы): УМЕМОТО Теруо (US) (43) Дата публикации заявки: 27.04.2011 Бюл. № 12 C 2 (56) Список документов, цитированных в отчете о поиске: OU et al. "Oxidative addition and isomerization reactions. The synthesis of cisand trans- ArSF4 Cl and cis- and trans- PhTeF4Cl", Canadian journal of chemistry, vol.75(12), 1997, p.p.1878-1884. OU et al. "Oxidative fluorination of S, Se and Те compounds", Journal of Fluorine Chemistry, vol.101, 2000, 279-283. RU 97107003 A, (см. прод.) C 2 2 4 7 2 7 7 9 2 4 7 2 7 7 9 (45) Опубликовано: 20.01.2013 Бюл. № 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 23.10.2009 (86) Заявка PCT: US 2008/057849 (21.03.2008) (87) Публикация заявки РСТ: WO 2008/118787 (02.10.2008) Адрес для переписки: 105082, Москва, Спартаковский пер., 2, стр. 1, секция 1, этаж 3, "ЕВРОМАРКПАТ" R U (54) СПОСОБ ПОЛУЧЕНИЯ ...

Process for preparation of 4-phenoxy-phenoxy-alkane-carboxylic acids

Method of preparing aminoketone derivatives or their salts

The invention concerns alpha -aminoacyl derivatives of phenyl-, phenoxy-, thiophenoxy- and phenylsulphinylalkanoic acids together with their amides, esters and pharmaceutically acceptable salts; processes for their preparation; and pharmaceutical compositions for therapeutic use in inhibiting the formation of thrombi and also in reducing the persistence of thrombi formed in the blood of warm blooded animals. Representative compounds of the invention are methyl 4-(aminoacetyl)phenoxyacetate, 4-(aminoacetyl)phenoxyacetic acid and methyl 4-(aminoacetyl)-thiophenoxyacetate, preferably as their hydrochlorides.

Copolymerizable uv stabilizers and their method

내용 없음. No content.

Synergistic antioxidant compositions

내용 없음. No content.

Patent JPH0529216B2

Method of preparing 1,2-benzisothothiazolinone-3derivatives

6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazolin-3-one is a representative embodiment, can be prepared by cyclization of an appropriately substituted bis-[2-(aminoalkylcarbamyl)phenyl]disulfide, or by other disclosed methods.

Method of preparation of 0,0-dimethyl-or 0,0-diethyl-0-(2,2-dichlorovinyl)-thiophosrhates

Alphaaamino ketone derivative*process for preparation thereof and pharmaceutical composition having inihibitory property against formation of insoluble fibrin from fibrin

Preparation method of pyrazoline derivatives

Pyrazolines I[R1=H, alkyl, Ph, cyanoalkyl or alkoxyalkyl; R2, R3=H, alkyl, Ph; R4=H or alkyl; X=H or halogen; W=O or S; Y,Z=H, halogen, alkyl, alkoxy, NO2, CF3, alkylthio, acyl, CN, alkylsulphonyl, alkoxycarbonyl or haloalkyl-A' or Y+Z form OCH2O; A'=O,S,SO or SO2) are prepd.. Thus, 4-HOC6H4COCH2Ph is treated with ClCHF2 to give 4- CF2OC6H4COCH2Ph which is treated with CH2O to give 4-CF2HOC6H4CO Ph; CH2. The latter is cyclized with N2H4 to give 3-(4- difluoromethoxyphenyl)-4-phenyl-2-pyrazoline which is treated with 4- ClC6H4NCO to give I(X=R2=R4=H, R1=Ph, W=O). (I) are broad-spectrum insecticides and are active against both young and old larvae.

Patent JPH0115826B2

Method of producing 2-substituted 1-napthols

2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung disease and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the groups CH2-C 3BOND C-(CH2)mR5 and CH=CH-(CH2)nR5 (where m is 1-4, n is 0-3 and R5 includes phenyl, COOR9, where R9 is H or alkyl or 1-4 carbons, AR6 (where A is a methylene chain and R6 is a variety of groups including Cl, Br, I, CHO, CN, COOR9, NH2, SC(NH)NH2, phenyl, P(O)(OR9)2, etc.), and CHR7R21 (where R7 is a variety of aromatic and heterocyclic groups and R21 is H, optionally substituted phenyl and a variety of heterocyclic groups).

Six-membered cyclic compound

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

The method of obtaining sulfonyl compounds

Benzophenone and manufacture

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Herbicidal composition

Method of obtaining a-substituted benzhydrol derivatives or salts thereof

Phosphorus-sulfur fire-protective additives and polymeric systems, which contain them

FIELD: chemistry. SUBSTANCE: claimed invention can be applied in chemistry of polymers and relates to phosphorus-sulfur compound, which is represented by structure and method of obtaining foamed polymer, which includes formation of molten mixture of combustible thermoplastic or thermoreactive polymer, at least, one foaming agent and claimed phosphorus-sulfur compound under pressure with the following extrusion of molten mixture. EFFECT: claimed is novel effective fire-protective additive for polymers and novel effective method of obtaining foamed polymer. 2 cl, 38 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 497 826 (13) C1 (51) МПК C07F 9/165 (2006.01) C08K 5/5398 (2006.01) C08J 9/00 (2006.01) C08L 101/12 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2012141583/04, 05.12.2007 (24) Дата начала отсчета срока действия патента: 05.12.2007 C 1 2 4 9 7 8 2 6 R U Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры" (54) ФОСФОРНО-СЕРНЫЕ ОГНЕЗАЩИТНЫЕ ДОБАВКИ И ПОЛИМЕРНЫЕ СИСТЕМЫ, СОДЕРЖАЩИЕ ИХ и способу получения вспененного полимера, который включает образование расплавленной смеси горючего термопластичного или термореактивного полимера, по меньшей мере, одного вспенивающего средства и указанного фосфорно-серного соединения под давлением с последующим экструдированием расплавленной смеси. Предложена новая эффективная огнезащитная добавка для полимеров и новый эффективный способ получения вспененного полимера. 2 н.п. ф-лы, 38 пр. (57) Реферат: Настоящее изобретение может быть использовано в химии полимеров и относится к фосфорно-серному соединению, представленному структурой Ñòð.: 1 ru (73) Патентообладатель(и): ДАУ ГЛОБАЛ ТЕКНОЛОДЖИЗ ЭлЭлСи (US) C 1 (56) Список документов, цитированных в отчете о поиске: GB 1532392 А, 15.11.1978. US 4388431 A, 14.06.1983. GB 2206590 A, 11.01.1989. US 4160795 A, 10.07.1979. Химическая энциклопедия/Под ред. И.Л. Кнунянца ...

Phenoxyalkylcarboxylic acid derivatives and process for their preparation

Phenoxyalkylcarboxylic acid derivatives of the following formula, wherein R¹ indicates hydrogen atom, methyl group or ethyl group, m is an integer from 2 to 5, and n is an integer from 3 to 8, X¹ and X² each independently represent sulfur atom, oxygen atom, sulfinyl group or sulfonyl group, proviso X¹ and X² are not simultaneously oxygen atom; their alkali salts and hydrates thereof are useful as antiallergic agents.

The method of obtaining dibenzoxazepine derivatives

Carboxyalkenamidocephalosporins

An antibacterial 7beta-(carboxyalkenoyl)amino-3-cephem-4-carboxylic acid represented by the following formula: ##STR1## (wherein R is aryl or a heterocyclic group; R 1 is hydrogen or halogen; R 2 is a single bond, alkylene, or thiaalkylene; R 3 is a hydrogen atom or carboxy modifying group; R 4 is hydrogen or methoxy; R 5 is hydrogen or a 3-substituent of cephalosporins; R 6 is a hydrogen atom or carboxy modifying group; and X is oxygen, sulfur, or sulfinyl) a pharmaceutical composition containing the same, and a method for treating a bacterial infection with the same.

Copolymeric ultraviolet stabilizer

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for the preparation of 3- (1, 2-dithia-cyclopentyl) -5-pentanoic acid

Polymer composition

Method of preparing derivatives of 4-phenyl-2-methyl-1-carboxylic acid

Method of producing substituted imidazopyrimidines,-pyrazines,or -triazines or salts thereof,which are acceptable in pharmacology

Compounds having the formula (I) <CHEM> and their pharmaceutically acceptable salts, wherein one or two of A1, A2, A3, and A4 is N, and the remaining A1, A2, A3, and A4 are CH, provided that if A4 is N, then one of A1, A2, and A3 is also N, and provided that one of A1, A2, and A3 may be CX where X is halo; and each of R1, R2, and R3 is independently hydrogen, C1-C4 alkyl, C1-C4, alkoxy, allyloxy, benzyloxy, (C1-C4 alkyl) thio, (C1-C4 alkyl) sulfinyl, (C1-C4 alkyl)sulfonyl, hydroxy, halo, cyano, nitro, amino, mono- or di-(C1-C4alkyl)amino, trifluoromethyl, or Z-Q-substituted C1-C4 alkoxy, wherein Q is oxygen, sulfur, sulfinyl, sulfonyl, or a bond, and Z is C1-C4 alkyl, phenyl or phenyl substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, nitro, amino, C1-C4 alkylthio, C1-C4 alkylsulfinyl, or C1-C4 alkylsulfonyl are ionotropic agents or intermediates thereto.