ЗАМЕЩЕННЫЕ БИАРИЛЬНЫЕ СОЕДИНЕНИЯ ИЛИ ЗАМЕЩЕННЫЕ ПИРИДИНЫ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ

Изобретение относится к биарильным соединениям или замещенным пиридинам формулы (I), где Х обозначает N или CR8, где R8 обозначает водород, галоген, фенил, алкил, алкокси, алкоксикарбонил, карбокси, формил или -NR4R5, где R4 и R5 обозначают водород, алкил, алкенил, циклоалкил, фенил, нафтил; R1a и R1в обозначают трифторметил, алкил, алкенил, алкинил, циклоалкил, алканоил; R2 обозначает алкил, алкенил, алкинил, циклоалкил; R3 обозначает гидрокси, трифторацетил, алканоил, алкенил; Аr обозначает ароматическое или гетероароматическое кольцо, например фенил, нафтил, пиридил, фуранил, тиофенил. Соединения формулы (I) обладают антагонистическим действием по отношению к рецептору глюкагона и могут быть использованы при лечении глюкагонмедиированных состояний, таких как диабет. 8 с. и 12 з.п. ф-лы, 2 табл.

НОВЫЕ АКТИВАТОРЫ РЕЦЕПТОРОВ ВИТАМИНА D И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

Настоящее изобретение относится к новым соединениям формулы (I) или их фармацевтически приемлемым солям, используемым для лечения или предупреждения расстройств, опосредуемых рецепторами витамина D, а также к фармацевтической композиции, содержащей данные соединения.В формуле (I) атом углерода, к которому присоединен X, имеет S или R конфигурацию, X представляет собой -CHOC(O)R, Yи Yкаждый представляет собой водород, Yи Yвместе образуют метиленовую группу, Zпредставляет собой фтор, гидроксильную группу или гидроксиметил, Zпредставляет собой фтор или гидроксильную группу, Rпредставляет собой Cалкил, Cалкиламино, CалкилкарбонилоксиCалкил или гидроксиCалкил. 3 н. и 2 з.п. ф-лы, 4 ил., 6 табл., 19 пр.

СПОСОБ ПОЛУЧЕНИЯ 4-МЕТОКСИМЕТИЛ-2,3,5,6-ТЕТРАФТОРБЕНЗОЛМЕТАНОЛА

... 1. Способ получения 4-метоксиметил-2,3,5,6-тетрафторбензолметанола, включающий i) взаимодействие 2,3,5,6-тетрафтор-1,4-бензолдиметанола с неорганическим основанием в воде, и затем ii) добавление диметилсульфата и несмешивающегося с водой органического растворителя, выбранного из группы, состоящей из углеводородов и простых эфиров, к реакционной смеси. 2. Способ по п. 1, в котором неорганическим основанием является гидроксид щелочного металла. 3. Способ по п. 2, в котором гидроксидом щелочного металла является гидроксид натрия. 4. Способ по п. 1, в котором несмешивающимся с водой органическим растворителем является толуол. 5. Способ по п. 1, в котором несмешивающимся с водой органическим растворителем является трет-бутилметиловый эфир. 6. Способ получения 4-метоксиметил-2,3,5,6-тетрафторбензолметанола, включающий i) взаимодействие 2,3,5,6-тетрафтор-1,4-бензолдиметанола с неорганическим основанием в воде и несмешивающимся с водой органическом растворителе, выбранном из группы, состоящей из ...

НОВЫЕ ПРОИЗВОДНЫЕ НОРБОРНАНА И НОРБОРНЕНА, ИХ ПРИМЕНЕНИЕ И СОДЕРЖАЩИЕ ИХ АРОМАТНЫЕ ПРОДУКТЫ

... 1. Соединение формулы где пунктиром отмеченная связь присутствует или отсутствует; и где R1 означает, когда пунктиром отмеченная связь присутствует -СНСН3ОН, или -СНСН3OCOR, или -СНСН3XCH2CHOHR', или -СНСН3OCHR'CH2ОН, или когда пунктиром отмеченная связь отсутствует -СНСН3ОН, или -СНСН3OCOR, или -СОСН3, или -СНСН3ХСН2CHOHR', или -CH2CH2XCH2CHOHR', или -СНСН3OCHR'СН2ОН, или -CHCHCOR', или -CH2CH2CHROH, или -CH2CH2CHR'OCOR, или -CHCHCHOHR', или -CHCHCHR'OCOR, где R означает Н, Me, Et, Pr, изоPr, But, изоBut, СН3(СН2)4, (СН3)2СНСН2, СН2СН или (СН3)2ССН; R' означает Н, Me или Et, и Х означает О, N или S. 2. Соединение по п.1, отличающееся тем, что пунктиром отмеченная связь отсутствует и R1 означает -СНСН3ОСН2СНОНСН3 или -СНСН3OCHR'CH2ОН. 3. Соединение по любому из пп.1 и 2 в виде диастереоизомера или энантиомера. 4. Соединение по любому из пп.1 и 2 в виде смеси диастереоизомеров. 5. Соединение по любому из пп.1 и 2 в виде рацемической смеси. 6. Способ получения соединения по любому из пп.1 ...

Способ получения винил-(2-оксипентин-4-окси)-алкиловых эфиров

Способ получения простых моноэфиров ацетиленовых бета-гликолей

Способ получения высших моноэфиров дипервичнотретичных глицеринов ацетиленового ряда

Способ получения алкил- или арилзамещенных 4-метоксибутен-2-ола-1

Способ получения производных 2-алкилглицерина

Способ получения амидов бифенилмасляной кислоты

Способ получения алкеновых производных или их солей

Изобретение касается ациклических ненасыщенных соединений , в частности, способов получения алмкеновых производных общей формулы R4-CH2-(CH2M)N-C(-C6H4-N-R1)-C(-C6H4-N-R2)*M99.(-C6H4-N-R3), где N=1 или 2 R1и MR2-H или OH R3-H, OH, OCH3или 2-(NM,N-диметиламино)-этоксил R4-CI или BR, или их м солей, обладающих эстрогенной, антиэстрогенной, прогестановмой и противоопухолевой активностью, что может быть использовано в медицине. Цель - создание новых активных соединений указанного класса. Синтез ведут реакцией соединения формулы R5-CH2-(CH2)N-CH(-C6H4-N-R6)-C(O)-C6H4-N-R7, где N имеет указанные значения R5-тетрагидропиран-2-илокси или бензилокси R6-H или тетрагидропиран-2-илокси R7-H, метокси или тетрагидропиран-2-илокси, с соединением общей формулы R8-C6H4-N-MG BR, где R8-H, метокси, 2-(N,N-диметиламино)этокси или тетрагидропиран-2-илокси. Образующееся соединение, в котором R8-тетрагидропиран-2-илокси или бензилокси, подвергают кислотному гидролизу с последующей дегидратацией и замещением гидроксильной ...

Verfahren zur Herstellung von Vitamin A und Zwischenprodukte

LOKALANAESTHETIKUM

Disclosed are mixtures of homologous lauryl polyglycol ethers of the formula: C12H25O(CH2-CH2O)x-H in which C12H25 is a straight-chain primary alkyl group and x has a mean value of 5 to 7. The homologous range of the ethers in the mixture is narrow, at least 75 % by wt. of the homologous mixture consisting of homologues with x = 4 to 8 glycol ether groups. Such mixtures exhibit a high local-anaesthetic action and are suitable for use as active substances in topical therapeutic and cosmetic applications.

POLYTETRAHYDROFURANVINYLETHER UND IHRE HERSTELLUNG

NEUE 3,5-DIHYDROXYCARBONSAEUREN UND DEREN DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS ARZNEIMITTEL, PHARMAZEUTISCHE PRAEPARATE UND ZWISCHENPRODUKTE.

... 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).

VERFAHREN ZUR HERSTELLUNG VON UEBER O,O'-METHYLENETHERGRUPPEN VERKNUEPFTEN PHENOLRESOLETHERN UND DEREN VERWENDUNG.

CHEMOLUMINESZENTE 3-(SUBSTITUIERTE ADAMANT-2'-YLIDENE)1,2-DIOXETANE

Bekaempfung von Schaedlingen, insbesondere von Milben

Hydroxy-Mischether, Verfahren zu deren Herstellung sowie deren Verwendung

Cyano-substituierte Verbindungen, die Ätherbindungen enthalten.

HYDROXYLIERTE FLUORVINYLVERBINDUNGEN UND DEREN POLYMERE.

PERFLUORALKYL-GRUPPEN ENTHALTENDE, ALPHA,BETA-UNGESAETTIGTE DI- UND TRIESTER UND HIERAUS HERGESTELLTE POLYMERISATIONSPRODUKTE

CHEMILIMINESZENTE 1,2-DIOXETAN-VERBINDUNGEN.

1.2.4-TRIAZOLIDINE-3.5-DIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

VERFAHREN ZUR HERSTELLUNG VON HALOPERIDOL

VERFAHREN ZUR HERSTELLUNG VON NORPATCHOULENOL

Verfahren zur Herstellung von Natriumaluminiumhydriden

PERFUMERY COMPOSITIONS COMPRISING DERIVATIVES OF ELGENOL

... 1414458 Perfumes BUSH BOAKE ALLEN LTD 6 Nov 1972 [12 Nov 1971 8 Sept 1972] 52706/71 and 41845/72 Heading A5B [Also in Division C2] Perfume compositions comprise compounds where R is C 1-6 alkyl, allyl or benzyl together with conventional perfumery adjuvents.

PROCESS FOR THE CONTINUOUS PREPARATION OF TRIMETHYLOL-ALKANE ALLYL ETHERS

... 1473024 Trimethylolalkane ethers BAYER AG 5 Aug 1975 [6 Aug 1974] 32690/75 Heading C2C Allyl ethers of the formula where X is 0 or 1 and n is 1, 2, or 3, are produced by the continuous etherification of a trimethylolalkane with allyl chloride under an inert atmosphere in the presence of an aqueous sodium hydroxide solution; the method comprises initially introducing the ether to be produced into at least two reaction chambers arranged in series, and introducing continuously, whilst stirring, the trimethylolalkane, 1À05-1À3 moles sodium hydroxide in a 40-50% aqueous solution and 1À0-1À2 moles of allyl chloride per mole of hydroxyl group to be etherified, to produce such concentrations that sodium salts of the trimethylolalkane do not precipitate, keeping the system at 80-130‹ C., and introducing continuously 0À5-1À7 parts by weight toluene relative to 1 part by weight of the sodium hydroxide, whilst azeotropically distilling off the water, to give a conversion of trimethylolalkane exceeding ...

BENZYL ETHER DERIVATIVES OF PENTITES

Novel Tricyclic Amines and a Process for the Manufacture Thereof

... 1,182,639. Dibenzo[a,d]cycloheptene derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 7 Nov., 1967 [8 Nov., 1966; 2 Feb., 1967], No. 50467/67. Heading C2C. Novel dibenzo[a,d]cycloheptene derivatives of the general formula wherein R is a chlorine or fluorine atom, R1 is a methyl group, R2 and R3 are each a chlorine or fluorine atom and X is an ethylene group or a vinylene group which may be substituted by a halogen atom and the broken lines denote optional bonds, and acid addition salts thereof are prepared (i) by reduction or dehydration of a hydroxy compound of the general formula wherein one of Y1 and Y2 is a hydrogen atom and the other is a hydroxy group; (ii) reaction of a 5-halo-substituted dibenzo[a,d]cycloheptene of the general formula wherein W is a halogen atom, with a dimethylaminopropyl magnesium halide; or (iii) by treatment of a 5-substituted dibenzo[a,d]cycloheptene of the general formula wherein Z is a halogen atom or a substituted ...

Boosters for high contrast silver halide imaging elements

PHARMACEUTICAL COMPOSITIONS CONTAINING DIPHENYLMETHANE DERI VATIVES

... 1390487 Pharmaceutical compositions containing diphenylmethane derivatives GRUPPO LEPETIT SPA 15 May 1973 [23 June 1972] 23068/73 Heading A5B [Also in Division C2] A pharmaceutical composition comprises a compound I in which R is one or two substituents selected from halogen, nitro and C 1-6 alkoxy, R 1 is hydrogen or one or two substituents selected from halogen, nitro, C 1-6 alkyl and C 1-6 alkoxy, R 2 is hydrogen, acyl derived from C 1-6 alkanoic acids or carbonic acids, carbanyl optionally mono-substituted by C 1-6 alkyl or optionally substituted phenyl and X is OR 3 or NHR 4 (in which R 3 is hydrogen, C 1-6 alkyl, optionally substituted phenyl or phenyl C 1-6 alkyl, acyl derived from C 1-6 alkanoic acids or carbonic acids or carbonyl optionally mono substituted by alkyl or optionally substituted phenyl and R, is hydrogen, C 1-6 alkyl or acyl derived from C 1-6 alkanoic acids or carbonic acids) and a solid or sterile liquid carrier. The compositions are CNS depressants and may be administered ...

Supported ruthenium nanoparticle catalyst for CIS- dihydroxylation and oxidative cleavage of alkenes

The present invention relates to the use of nanosized metal particles (e.g., ruthenium) grafted on inert solid support for oxidation of alkenes. The supported metal catalyst can effect cis-dihydroxylation and oxidative cleavage of alkenes to give the respective cis-diols and carbonyl products.

Preparation of aminoacetonitrile derivatives

... 2-Fluorinated methyl aminoacetonitriles are prepared by treating a corresponding fluorinated methyl ketimine magnesium halide with hydrogen cyanide or with an alkali metal cyanide or ammonium cyanide and a proton source.

HERBICIDAL TETRAHYDROFURAN DERIVATIVES

Phenethanolamine derivatives

PROCESS FOR THE OXIDATION OF ALPHA-OLEFINS

A process for the oxidation of alpha-olefins having from 3 to about 30 carbon atoms, in which the alpha-olefin and molecular oxygen are contacted in the presence of a solution of a Group VIII metal complex containing at least one NO2 or NO ligand, a divalent copper salt and a tertiary alcohol as solvent.

Novel N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones, their process of preparation and their application in thera

N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones are disclosed. These compounds possess antidepressant activity.

N-aryl oxazolidinones and pyrrolidinones and their processes

N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones are disclosed. These compounds possess antidepressant activity.

OXIDATION OF ALPHA-OLEFINS

chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes

Substituted dioxanes and their application like weedkillers.

PESTICIDAL COMPOUNDS

PESTICIDAL COMPOUNDS

Weedkillers compositions.

Derived from oxabicycloalcane with weedkiller activity.

PESTICIDAL COMPOUNDS

KETONE AND REDUCED KETONE AS THERAPEUTIC MEANS FOR THE TREATMENT OF BONE ILLNESSES

VERFAHREN ZUR HERSTELLUNG VON NEUEN PHENAN- THRENEN

VERFAHREN ZUR HERSTELLUNG VON NEUEN PHENAETHANOLAMINVERBINDUNGEN UND IHREN SALZEN UND SOLVATEN

Phenethanolamine derivatives are disclosed of formula wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R1 and R2 are hydrogen or alkyl provided that the sum total of carbon atoms in R1 and R2 is not more than 4; and the physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant action at beta 2-adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients. The compounds may be prepared, for example by alkylation of an amine: where R3, R5 and R6 is hydrogen or a protecting group, followed by removal of any protecting group.

PROCEDURE FOR THE PRODUCTION OF NEW PHENAN THRENEN

NORBORNAN AND NORBORNENDERIVATE, YOUR USE AND THESE CONTAINING ODORIFEROUS SUBSTANCE PRODUCTS

HERBIZIDES MITTEL

VERFAHREN ZUR HERSTELLUNG VON NEUEN AZACACLOALKANEN

VERFAHREN ZUR HERSTELLUNG VON AETHERN

PROCEDURE FOR THE PRODUCTION OF CHIRALER OF SUBSTITUTED DIOLE AND DIOLANALOGER DERIVATIVES

VERFAHREN ZUR HERSTELLUNG NEUER (4-BIPHENYLYL) -ALKOHOLE

VERFAHREN ZUR KONTINUIERLICHEN HERSTELLUNG VON TRIMETHYLOLALKANALLYLATHERN

NEW PROCEDURE FOR THE ISOMERIZATION OF CONDENSING BICYCLI STRUCTURES AND PRODUCTION OF THIS CONTAINING VITAMIN D ANALOGUES

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) - 1-BUTANOLE

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) - ALCOHOLS

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) -3-BUTEN-1-OLE

CYCLIZIERTE SIMILAR ONE OF THE FATTY ACID METABOLITES, PROCEDURES FOR YOUR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL COMPOSITIONS

3,9-DISUBSTITUIERTE-SPIRO (5.5) UNDECANE ALSO CARDIOVASCULAIRE EFFECT, PROCEDURE FOR THEIR PRODUCTION AND IT ABSTENTION PHARMACEUTICAL ONE PREPARATIONS

OPTICALLY ACTIVE HALOGENHYDRINDERIVAT AND PROCEDURES FOR THE PRODUCTION OF AN OPTICALLY ACTIVE ONE EPOXYALKOHOLDERIVATS OF IT

CHEMILIMINESZENTE 1,2-DIOXETAN-VERBINDUNGEN

REGULATION OF THE MOLECULAR WEIGHT AND ENDGRUPPENFUNKTIONALTITÄT FROM POLYMERS.

2.3-DIALKOXYPROPYLGLYCERYLAETHER, PROCEDURE FOR THEIR PRODUCTION AND THIS CONTAINING COSMETIC COMPOSITION.

8 (NIEDERALKYL) BICYCLO (4.2.0>OCTANDERIVATE WITH VALUABLE THERAPEUTIC CHARACTERISTICS.

SEBOSUPPRESSIVE COSMETIC MEANS, CONTAINING BENZYLE ALCOHOL DERIVATIVES.

MORE OCTADIENYLAETHER AND PROCEDURES FOR THE PRODUCTION OF OCTADIENYLAETHERN.

PROCEDURE FOR the PRODUCTION 1,4-DISUBSTITUIERTER 2 - BUTENE.

O-ECYL-ALKANDIOL-PHOSPHOLIPIDE, PROCEDURES FOR YOUR PRODUCTION AND IT ABSTENTION PHARMATEUTI COMPOSITIONS.

INTERMEDIATE PRODUCTS IN THE SYNTHESIS OF VITAMIN D DERIVATIVES.

PRO DAY LANDIN SIMILAR TO.

PROCEDURE FOR THE PRODUCTION OF BICYCLOHEPTANDERIVATEN AND BICYCLOHEPTAN DERIVATIVES.

INTERMEDIATE PRODUCTS AND THEIR USE FUER THE SYNTHESIS OF ORGANIC COMPOUNDS.

HERBICIDE MEANS

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) - 1-BUTANOLE

POLYALKOXYLIERTE TERPENDERIVATE AND IT CONTAINING COMPOSITIONS

PROCEDURES FOR THE PRODUCTION OF UEBER O, O'METHYLENETHERGRUPPENVERKNUEPFTEN PHENOLRESOLETHERN AND THEIR USE.

PROCEDURE FOR THE PRODUCTION OF GLYZERINETHERN AND YOUR USE.

INHIBITORS SLOWLY OF THE REACTIONS ANAPHYLAKTI SUBSTANCE.

DRUG WITH IMPROVED PENETRATION OF THE GEWEBSMEMBRAN.

PRODUCTION OF OPTICALLY ACTIVE DERIVATIVES OF 4 - DEMETHOXYDAUNOMYCINON.

INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF GLYCERINDERIVATEN.

2-ARYLPROPENSÄUREN AND YOUR USE WITH the PRODUCTION OF S-KETOPROFEN

PROCEDURE FOR the PRODUCTION OF NEW ONE 9,10-SECO-OSTRAN-DERIVATEN

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) - 1-BUTANOLE

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) - 1-BUTANOLE

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) -3-BUTEN-1-OLE

PROCEDURE FOR the PRODUCTION of NEW (4-BIPHENYLYL) -1-BUTANOLE

Procedure for the production of new D-Arabinoseverbindungen

SELECTIVE ALKYLATION OF A BY AN ALCOHOL SUBSTITUTED PHENOL CONNECTION

PENTASUBSTITUIERTE PHENYLE.

MONOMERS DIOLE AND FROM IT EDUCATION PHOSPHATE-LINKED OLIGOMERE

PROCEDURE FOR THE PRODUCTION OF FLUOROCARBONS, USE AS COOLING AGENTS AS WELL AS LUBRICANT FOR MAGNETIC RECORDING MEDIA

POLYETHERS, POLYAMINES, POLYTHIOETHERS, AND METHODS FOR MAKING SAME

The invention relates to polyethers, polyamines, and polythioethers, as well as to processes for synthesizing them, e.g., using olefins as starting material. 2. The compound of claim 1 , wherein X is O.3. The compound of claim 1 , wherein X is NH.4. The compound of claim 1 , wherein X is S.5. The compound of claim 1 , wherein Ris optionally substituted linear C-Calkyl or branched C-Calkyl.6. The compound of claim 1 , wherein Ris unsubstituted linear C-Calkyl or branched C-Calkyl.7. The compound of claim 1 , wherein Ris optionally substituted linear C-Calkenyl or branched C-Calkenyl.8. The compound of claim 1 , wherein Ris unsubstituted linear C-Calkenyl or branched C-Calkenyl.9. The compound of claim 1 , wherein n is 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , or 10.10. The compound of claim 1 , wherein n is 2 or 3.12. The method of claim 11 , wherein the reaction of a compound of Formula II or Formula III with methane sulfonic acid comprises an incubation step claim 11 , quenching step claim 11 , a phase separation step claim 11 , and a distillation step.13. The method of claim 12 , wherein the incubation step occurs at room temperature.14. The method of claim 12 , wherein the incubation step occurs over four days.15. The method of claim 11 , wherein the distillation step occurs at 85° C.16. The method of claim 11 , wherein the distillation step occurs at 1.5 mbar.17. The method of claim 11 , further comprising an amidation step claim 11 , wherein a compound of Formula I claim 11 , wherein X is O claim 11 , reacts with NHunder an elevated pressure to obtain a corresponding compound of Formula I claim 11 , wherein X is NH.19. The method of any one of claim 11 , wherein the compound of Formula II is citronellol. This application claims the benefit of and priority to U.S. Provisional Patent Application No. 62/043,943, filed Aug. 29, 2014, titled, “POLYETHERS, POLYAMINES, POLYTHIOETHERS, AND METHODS FOR ...

HYDROXY MIXERS, METHOD FOR THE PRODUCTION AND USE THEREOF

4-Methoxy-2-ethyl phenol prepn. - from a methoxy ethyl halide, magnesium, 4:bromo phenol ether and acid

4-Methoxy-2-ethyl phenol of formula (I) is prepared from a 2-methoxy ethyl halide of formula CH3OCH2CH2X (II) (where X is Cl, Br or I). (II) is treated with Mg to form the corresp, halide. This is treated with a bromophenol ether of formula (III) (where R is a group that is easily removed below 70 deg.C by acid) to give 4-(2-methoxy ethyl)phenol ether offormula (IV) which is treated with an acid to give (I). The reaction in which R is a tetrahydropyranyl, methoxymethyl, ethoxymethyl, and alpha methyl or ethyl ethoxymethyl group is partic. pref. (I) is an intermediate for the prepn. of the cardiovascular agent metoprolol.

Prepn. of 4-methoxyethyl phenol - from a 4-alkoxyphenyl bromide and a 2-methoxyethyl halide

phenol of formula (I) is prepd. by treating a 4-alkoxyphenyl bromide (II) with Mg to form the corresponding magnesium bromide (III) (where R is a gp. that can be eliminated by mineral or organic acid below 70 deg.C); reacting (III) with 2-methoxyethyl chloride, bromide, or iodide to give (IV) and treating this with acid to give (I). Process in which R is tetrahydropyranyl, methoxymethyl, ethoxymethyl or alpha alkyl ethoxymethyl, is pref. The prepn. of the magnesium bromide (III) is pref. effected in a mixed ether solvent, esp. diethyl ether and (THF). Reaction of (III) with the 2-methoxyethyl halide is effected in THF, and elimination of the gp. R is effected with an acid in an alcoholic medium. (I) are intermediates for the cardiovascular agent metoprolol.

Process for the preparation of hydroxy substituted polyethers

Optical oxygen sensor

Abstract An optical oxygen sensor which is based on a transfer of electromagnetic energy from a donor to an acceptor is described. Pyrene derivatives of the general formula I wherein R signifies an alkyl group with up to 30 C atoms which is substituted with a hydroxy or amino group or a group of the formula -NH(1-8C alkyl), a group -CH2-OR in which R has the aforementioned significance, a group -OR in which R has the aforementioned significance or a group -R'-O-R'' in which R' signifies an alkylene group, R'' has the above significance of R and R' and R'' together have not more than 30 C atoms and n signifies a whole number of 1-10, are used as the O2-indicators or as the donors. 1-Hydroxymethylpyrene, 1-(11-hydroxyundecyl)pyrene, 1-(11-hydroxyundecyloxymethyl)pyrene and 1-(2-aminoethyl-oxymethyl)pyrene are preferred pyrene derivatives. Perylene derivatives of the general formula II wherein R and n have the aforementioned significance, are used as the acceptors. 3-Hydroxymethylperylene, 11-amino-1-(3-perylene-methoxy)undecane, 3-(2-aminoethyloxymethyl)perylene and 3-(11-hydroxyundecyloxymethyl)perylene are preferred acceptors.

Hydroxy-substituted polyethers, their derivatives and preparation

Patent FR2487339B1

Optical oxygen sensor

A description is given of an optical oxygen sensor based on a transfer of electromagnetic energy from a donor to an acceptor. As O2 indicators or as donors, use is made of pyrene derivatives of the general formula <IMAGE> where R is an alkyl group containing up to 30 carbon atoms and substituted with a hydroxy or amino group or a group of the formula -NH(1-8C alkyl), or a -CH2-OR group, where R has the abovementioned meanings, or is an -OR group, where R has the abovementioned meanings, or is an R'-O-R'' group, where R' is an alkylene group, R'' has the above meaning of R and R' and R'' taken together do not contain more than 30 carbon atoms, and n is an integer from 1 to 10. Preferred pyrene derivatives are 1-hydroxymethylpyrene, 1-(11-hydroxyundecyl)pyrene, 1-(11-hydroxyundecyloxymethyl)pyrene or 1-(2-aminoethyloxymethyl)pyrene. The acceptors used are perylene derivatives of the general formula <IMAGE> where R and n have the abovementioned meanings. Preferred acceptors are 3-hydroxymethylperylene, 11-amino-1-(3-perylenemethoxy)undecane, 3-(2-aminoethyloxymethyl)perylene or 3-(11-hydroxyundecyloxymethyl)perylene.

Intermediate products for the production of glycerol derivatives

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Glycerol derivatives of the formula : - see diagramm : EP0072940,P15,F1 wherein each of the radicals R'1 , R'2 and R'3 is different and signifies a benzyl group or allyl group, R'1 and R'3 also a trityl group. 1. Claims for the Contracting State : AT Process for the preparation of glycerol derivatives of the formula II : see diagramm : EP0072940,P17,F1 wherein each of the radicals R'1 , R'2 and R'3 is different and signifies a benzyl group or allyl group, R'1 and R'3 also a trityl group, in that into a 1- (or 3-) benzyl- (or allyl-) glycerol one introduces the trityl group into the 3- (or 1-) position and thereafter the allyl (or benzyl) group into the 2-position.

POLYETER GLYCOLS AND ALCOHOLS DERIVED FROM 3,4-EPOXY-1-BUTENE.

SE REVELAN NUEVOS COMPUESTOS DE POLIETER OBTENIDOS POR LA REACCION O POLIMERIZACION DE 3.4-EPOXI-1-BUTENO EN PRESENCIA DE UN CATALIZADOR ACIDO Y UN COMPUESTO INICIADOR NUCLEOFILICO. LOS COMPUESTOS DE POLIETER INCLUYEN N UNIDADES DE RESIDUO (1) Y M UNIDADES DE RESIDUO (2) EN DONDE EL VALOR TOTAL DE N+M ES 2 HASTA 70, N/(N+M) ES UN VALOR EN EL RANGO DE 0.70 HASTA 0.95 Y LOS RESIDUOS (1) Y (2) TIENEN LAS ESTRUCTURAS (1 Y 2). NEW POLYETER COMPOUNDS OBTAINED BY THE REACTION OR POLYMERIZATION OF 3.4-EPOXI-1-BUTENE IN THE PRESENCE OF AN ACID CATALYST AND A NUCLEOPHILIC INITIATOR COMPOUND ARE REVEALED. POLYETER COMPOUNDS INCLUDE N UNITS OF WASTE (1) AND M UNITS OF WASTE (2) WHERE THE TOTAL VALUE OF N + M IS 2 UP TO 70, N / (N + M) IS A VALUE IN THE RANGE OF 0.70 TO 0.95 AND THE WASTE (1) AND (2) HAVE THE STRUCTURES (1 AND 2).

Synthetic endogenous cannabinoids analogues and uses thereof

Hydroxy-mixed ethers, method for their production and their application

Die Erfindung betrifft Hydroxyalkylpolyethylen- und Hydroxyalkylpolypropylenglykolether der allgemeinen Formel (I) <IMAGE> in der R¹ für einen linearen Alkylrest mit 6 bis 16 C-Atomen, R² für einen geradkettigen oder verzweigten, gesättigten oder ungesättigten Alkylrest mit 1 bis 22 C-Atomen, R³ für Wasserstoff oder eine Methylgruppe und n für eine Zahl von 0 bis 30 stehen, sowie Mischungen mehrerer derartiger Verbindungen, ein Verfahren zur Herstellung derartiger Hydroxy-Mischether, das dadurch gekennzeichnet ist, daß man geeignete Epoxide mit geeigneten Alkoholalkoxylaten bei erhöhter Temperatur unter Schutzgas in Gegenwart eines Katalysators umsetzt, sowie die Verwendung der genannten Verbindungen oder ihrer Mischungen als schaumdrückende Zusätze in schaumarmen Reinigungsmitteln. The invention relates to hydroxyalkyl polyethylene and hydroxyalkyl polypropylene glycol ethers of the general formula (I) <IMAGE> in which R¹ is a linear alkyl radical having 6 to 16 C atoms, R² is a straight-chain or branched, saturated or unsaturated alkyl radical having 1 to 22 C atoms, R³ is hydrogen or a methyl group and n is a number from 0 to 30, and mixtures of several such compounds, a process for the preparation of such hydroxy mixed ethers, which is characterized in that suitable epoxides with suitable alcohol alkoxylates at elevated temperature in a protective gas The presence of a catalyst and the use of the compounds mentioned or their mixtures as foam-suppressing additives in low-foam cleaning agents.

Polyether glycols and alcohols derived from 3,4-epoxy-1-butene

Process for the preparation of 1-isopropylamino-3-(4-(2-methoxy-ethyl)-phenoxy)-2-propanol

A process for the preparation of 1-isopropylamino- 3-[4-(2-methoxyethyl)phenoxy]-2-propanol of the formula comprising the reduction of 4-(methoxyethanoyl)phenol to 4-(1-hydroxy-2-methoxyethyl)phenol, which is reacted with methanol or ethanol at acid conditions to the corresponding 4-(1-alkoxy-2-methoxyethyl)-phenol. This compound is reacted with epichlorohydrine to 1,2-epoxy-3-[4-(1-alkoxy-2-methoxyethyl)phenoxy]propane, which after reaction with isopropylamine gives 1-isopropylamino-3-[4-(1-alkoxy-2-methoxyethyl)phenoxy]-2-propanol, which in the last step is hydrogenated catalytically to a compound of formula (I).

Fatty alcohol alkoxylate

Fatty alcohol alkoxylate

A compound of the formula ##STR1## where R, which may be the same or different, is selected from at least one of hydrogen, methyl, ethyl and phenyl, at least one R on each --OCHR--CHR-- unit being hydrogen; where m is an integer selected from 1-100; where n is an integer selected from 8 and 9. The preferred process of preparation is by the reaction of alkylene oxide with linoleyl alcohol in the presence of a catalyst which is a Bronsted base. The compounds are useful as reactive surfactants in aqueous emulsion polymerisation processes.

PROCESS OF PREPARING 1 (P-HYDROXIFENYL) -2-METOXYETANE

Substituted 1,3-dioxanes as herbicides

Herbicide composition

Preparation of optically active 4-demethoxydaunomycinone

A process for preparing optically active 4-demethoxy-7-deoxydaunomycinone which comprises reacting a racemic mixture of the α-hydroxyketone of the formula: ##STR1## with an optical isomer of the α-glycol of the formula: ##STR2## wherein R is a group of the formula: ##STR3## and X is a halogen atom or a lower alkyl group to give a diastereomeric mixture of the acetal of the formula: ##STR4## .

Patent JPH027937B2

A process for the preparation of 1-isopropylamino- 3-[4-(2-methoxyethyl)phenoxy]-2-propanol of the formula <CHEM> comprising the reduction of 4-(methoxyethanoyl)phenol to 4-(1-hydroxy-2-methoxyethyl)phenol, which is reacted with methanol or ethanol at acid conditions to the corresponding 4-(1-alkoxy-2-methoxyethyl)-phenol. This compound is reacted with epichlorohydrine to 1,2-epoxy-3-[4-(1-akoxy-2-methoxyethyl)phenoxy]propane, which after reaction with isopropylamine gives 1-isopropylamino-3-[4-(1-alkoxy-2-methoxyethyl)phenoxy]-2-propanol which in the last step is hydrogenated catalytically to a compound of formula (I).

Synthetic endogenous cannabinoid analogues and uses thereof

Process for the preparation of hydroxybenzyl ethers

Verfahren zum Herstellen partieller Alkylaether mehrwertiger Alkohole

Phenolverbindungen, die Methoxymethylgruppen oder Hydroxymethylgruppen enthalten

Bisymmetrical phenolic compounds

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내용없음

Verfahren zur Herstellung von Kondensationsprodukten

一种甘油醚类气干剂的制备方法

本发明公开了一种甘油醚类气干剂的制备方法，属于有机化合物合成技术领域。该制备方法包括如下步骤：先将甘油和催化剂加入反应釜内，然后分步加入碱金属氢氧化物水溶液和卤代烯烃，在一定温度下进行反应，每步反应结束后，去除下层水相和固体，取上层有机相继续参与下一步反应，蒸馏后即得。本发明通过相转移催化剂催化反应进行，可促进传质传热，有利于产品分布变窄，通过本发明的制备方法得到的产品中二醚的含量达到93％以上，成本低、无有机溶剂，适合工业化生产。

Synthetisches Schmiermittel fuer feinmechanische Instrumente, insbesondere Uhren, und Verfahren zu seiner Herstellung

Novel trisphenol derivative

In order to provide a novel compound that has good solvent solubility, has high storage stability (dissolution stability) during refrigerated or frozen storage, and can be used as a crosslinking agent, a substituted trisphenol compound represented by formula (2) below is provided:

Process for preparing benzyl ethers

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내용 없음.

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新穎之三酚衍生物

本發明之課題係提供一種可作為交聯劑使用之新穎化合物，其對溶劑的溶解性良好，並且在冷藏或冷凍保存時的保存穩定性(溶解穩定性)高。上述課題之解決手段係提供一種下述式(2)所示之取代三酚化合物。

Glyceryl ethers

THE INVENTION DISCLOSED HEREIN RELATES TO GLYCERYL ETHERS HAVNG THE GENERAL FORMULA I R1,R2,R3,R4,R5,((R6,R7,R8,R9,R10-PHENYL)-CH(-O-CH2- CH(-OH)-CH2-OH)-)BENZENE THE COMPOUNDS OF THIS INVENTION HAVE BEEN FOUND TO HAVE ACTIVITY AS MUSCLE RELAXANTS, ANTI-CONVULSIVES AND SEDATIVES.

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éthers glycoliques et leur application comme antiparasitaires

Procedimiento para la preparacion de benzhidrilglicerile- teres.

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(diphenylmethoxy)-propane-1,2-diols and their preparation

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Procedimiento para la preparacion de benzhidrilglicerile- teres.

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Lubrifiant synthétique pour instruments mécaniques de précision, notamment pour montres, et son procédé de fabrication

一种季戊四醇三烯丙基醚的制备方法

本发明公开了一种季戊四醇三烯丙基醚的制备方法，其中，所述方法包括：提供反应原料及催化剂，加热至预设温度并保温至第一预设时间，控制以第一模式进行分水并以第一预设速度滴加氯丙烯5小时后，得到第一阶段反应产物；分三次向上一反应步骤的产物中投入碱液及催化剂并控制分别以第二分水模式、第三分水模式、第四分水模式进行分水，其中，所述以第一模式分水包括所有反应时间内不进行分水，所述第二模式分水包括在部分反应时间内分水，所述第三模式分水包括所有反应时间内分水，所述第四模式分水包括所有反应时间内分水。通过控制不同的分水模式，能够有效提高三醚的选择性，有效的降低季戊四醇三烯丙基醚的成本，有利于其应用领域进一步扩展。

一种季戊四醇三烯丙基醚的制备方法

本发明公开了一种季戊四醇三烯丙基醚的制备方法，其中，所述方法包括：提供反应原料及催化剂，加热至预设温度并保温至第一预设时间，控制以第一模式进行分水并以第一预设速度滴加氯丙烯5小时后，得到第一阶段反应产物；分三次向上一反应步骤的产物中投入碱液及催化剂并控制分别以第二分水模式、第三分水模式、第四分水模式进行分水，其中，所述以第一模式分水包括所有反应时间内不进行分水，所述第二模式分水包括在部分反应时间内分水，所述第三模式分水包括所有反应时间内分水，所述第四模式分水包括所有反应时间内分水。通过控制不同的分水模式，能够有效提高三醚的选择性，有效的降低季戊四醇三烯丙基醚的成本，有利于其应用领域进一步扩展。

新型三酚衍生物

本发明的课题在于提供一种对溶剂的溶解性良好，在冷藏或冷冻保存时的保存稳定性(溶解稳定性)高，可作为交联剂使用的新型化合物。作为解决方法，提供一种下述式(2)所表示的取代三酚化合物。

一种甘油醚类气干剂的制备方法

本发明公开了一种甘油醚类气干剂的制备方法，属于有机化合物合成技术领域。该制备方法包括如下步骤：先将甘油和催化剂加入反应釜内，然后分步加入碱金属氢氧化物水溶液和卤代烯烃，在一定温度下进行反应，每步反应结束后，去除下层水相和固体，取上层有机相继续参与下一步反应，蒸馏后即得。本发明通过相转移催化剂催化反应进行，可促进传质传热，有利于产品分布变窄，通过本发明的制备方法得到的产品中二醚的含量达到93％以上，成本低、无有机溶剂，适合工业化生产。