СПОСОБ ПОЛУЧЕНИЯ 2,3,5-ТРИМЕТИЛБЕНЗОХИНОНА ПРИ ПОМОЩИ ОКИСЛЕНИЯ 2,3,6-ТРИМЕТИЛФЕНОЛА

FIELD: chemistry; technological processes. SUBSTANCE: present invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a mixture containing 2,3,5-trimethyl benzoquinone, which are used to produce vitamin E. Method comprises the step of oxidation of 2,3,6-trimethylphenol to 2,3,5-trimethyl benzoquinone with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least a copper (ll) halide, so that a mixture containing 2,3,5-trimethyl benzoquinone is formed. Reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more carbon atoms. Invention also relates to a mixture for the synthesis of vitamin E containing 2,3,5-trimethyl benzoquinone, to use of a secondary aliphatic acyclic alcohol having 6 or more carbon atoms and to use of the mixture produced by the proposed method. EFFECT: proposed method allows maximally preventing the formation of chlorinated byproducts, thereby improving the selectivity of the process. 18 cl, 1 tbl, 12 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 668 962 C2 (51) МПК C07C 46/08 (2006.01) C07C 50/02 (2006.01) C07C 31/125 (2006.01) C07D 311/72 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 46/08 (2006.01); C07D 311/72 (2006.01) (21)(22) Заявка: 2016103145, 25.06.2014 (24) Дата начала отсчета срока действия патента: Дата регистрации: 05.10.2018 02.07.2013 EP 13174688.5; 02.07.2013 US 61/841,946 (56) Список документов, цитированных в отчете о поиске: EP 0369823 А1, 23.05.1990. EP (43) Дата публикации заявки: 07.08.2017 Бюл. № 22 0475272 B1, 11.01.1995. RU 2163600 C2, 27.02.2001. RU 2165406 C1, 20.04.2001. (45) Опубликовано: 05.10.2018 Бюл. № 28 C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 02.02.2016 (86) Заявка PCT: EP 2014/063425 (25.06.2014) 2 6 6 8 9 6 2 (87) Публикация заявки PCT: R U 2 6 6 8 9 6 2 (73) ...

СПОСОБ ПОЛУЧЕНИЯ 2,3,6-ТРИМЕТИЛ-П-БЕНЗОХИНОНА

... 1. Способ получения 2,3,6-триметил-n-бензохинона путем окисления 2,3, 6-триметилфенола кислородом или кислородсодержащим газом в среде воды и алифатического спирта в присутствии катализатора - солевой системы галогенидов меди и лития, отличающийся тем, что в качестве алифатических спиртов используют спирты C1 - С4, реакцию проводят при рН 2,9-4,5 при концентрации 2,3,6-триметилфенола 0,5-9% с непрерывной экстракцией целевого продукта ароматическим углеводородом. 2. Способ получения по п.1, отличающийся тем, что реакцию проводят при рН 3,1-3,6. 3. Способ получения по п.1, отличающийся тем, что реакцию проводят при концентрации 2,3,6-триметилфенола 1,5-3%.

VERFAHREN ZUR HERSTELLUNG VON 2,3,5-TRIMETHYL-P-BENZOCHINON

VERFAHREN ZUR HERSTELLUNG VON 2,3,5-TRIMETHYL-P-BENZOCHINON

Ionic liquids, method of their production and process for generating hydrogen peroxide

A method for the purification of dicarboxylic acids

Long-chain dicarboxylic acids are purified by dissolving the acids or their salts in a lower aliphatic alcohol or tetrahydrofuran or an aqueous solution of the alcohol or tetrahydrofuran, removing insoluble solids from the solution and recovering the acids from the solids- free solution by precipitation and filtration. This method is particularly suitable for the purification of acids produced by fermentation of, for example, a normal paraffin substrate by means of a yeast fungi or bacteria. The method removes residual solids originating from the fermentation broth.

PROCEDURE FOR THE PRODUCTION OF A SEMITRICHINOYL CONTAINING SOLUTION

PROCEDURE FOR THE PRODUCTION OF TRIMETHYLBENZOCHINON.

QUINONDERIVATE, YOUR PRODUCTION AND USE.

ALPHA, OMEGA DICARBONIC ACIDS, PROCEDURES FOR YOUR PRODUCTION AND DRUG, THESE CONNECTIONS CONTAINING.

PROCEDURE FOR the PRODUCTION OF 2,3,5-TRIMETHYL-P BENZOCHINON

NEW HYDROCHINONDERIVATIVEN AS INTERCEPTORS FOR DEVELOPER OXIDIZED

Bioreductive cytotoxic agents

PROCESS FOR THE MANUFACTURE OF BENZOQUINONES

PROCEDE DE PREPARATION DE TRIMETHYLBENZOQUINONE

QUINONE COMPOUNDS FOR TREATING APE1 MEDIATED DISEASES

The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and pharmaceutical compositions containing them for treating Ape1 mediated diseases.

Verfahren zur Darstellung eines Kondensationsproduktes.

Verfahren zur Herstellung von Trimethyl-p-benzochinon

Benzoquinones prepn and application

Benzoquinones are made by heating the corresponding p-nitrosophenol at below pH7 with water at 150-200 degrees C; in presence of a lower aldehyde or ketone, pref. acetone. The reaction is applied esp. to p-nitrosophenols substituted in one or both o-positions (to OH) with C3-12 alpha-branched alkyl, esp. mono- and di-tert. butyl. The products are readily reduced to the corresponding hydroquinones. Used as antioxidants for e.g. petrols, plastics, rubbers etc.

Optionally substituted p- or o- benzoquinone - prodn

Opt. substd. p- or o-nitrosophenol is reacted with oxygen at 75-200 degrees C in contactw with an oxidation catalyst comprising transition metal oxides and/or salts to produce the corresponding benzoquinones (esp. p- or reduced to the corresponding hydroquinones (the latter are valuable antioxidants and reducing agents).

Procédé de préparation de quinones par oxydation thallique de phénols

Alkyl-substd para or orth benzoquinone prodn - by oxidation of corresp nitrosophenols

... p- or o-Benzoquinones substd. at least in the o-position with an alpha-branched 3 - 12C alkyl are prepd. by reacting the corresp. nitrosophenol with an oxidising agent having a standard oxidation potential below -0.40 V (pref. Na2Cr2O7), at 25 - 125 degrees C in an acidic reaction medium. Benzoquinones so produced are used in the mfr. of the corresp. substd. hydroquinones (pref. by catalytic hydrogenation), which are used as antioxidants e.g. for foodstuffs, or as reducing agent in chemical reactions.

Methyl-substd quinones prepn - by oxidn of phenols with oxygen in the presence of copper and halide ions

Cpds. of formula (I): (where >=1 pref. 3 of R1-R4 is Me and the other(s) are H or Me) are prepd. by oxidising a cpd. of formula (II): (where X is H, Br, Cl or I) with O2 or an O2-contg. gas in a solvent, pref. 2-methyoxyethanol, acetone or DMF, in the presence of Cu and halogen ions (pref. in the form of CuCl2), and opt. in the presence of a complexing agent, pref. NEt3, Ph3P or Ph3As, provided that the complexing agent is only present up to a molar ratio of Cu to complexing agent of 1:2. The reaction temp. is pref. 50-70 degrees C and the O2 press. 1-50 atm; molar ratio of Cu to (II) is pref. 0.5-2:1; prodts. are inters. for tocophenols.

Process for the preparation of p-quinones

PROCEDURE FOR the PRODUCTION OF 2,3,5-TRIMETHYLHYDROCHINON.

СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИМЕТИЛБЕНЗОХИНОНА

Изобретение относится к усовершенствованному способу получения 2,6-диметилбензохинона (2,6-DMQ).

Method for separating and purifying 2,3,5-trimethyl benzoquinone

Process of O-hydroquinone oxidation and products obtained

Process for the production of azo dyes

Process for the preparation of P-benzoquinones

PROCEDE DE PREPARATION DE BENZOQUINONES

SETT ATT FRAMSTELLA METYLSUBSTITUERADE KINONER

alpha , omega -dicarboxylic acids and medicaments which contain these compounds

PCT No. PCT/EP85/00288 Sec. 371 Date Feb. 21, 1986 Sec. 102(e) Date Feb. 21, 1986 PCT Filed Jun. 15, 1985 PCT Pub. No. WO86/00298 PCT Pub. Date Jan. 16, 1986. (I') (II) alpha , omega -dicarboxylic acids having the general formula (I') in which: R1 and R2, which may be different or the same, represent a lower alkyl group which can be substituted by hydroxy, lower alkoxy, halogen or phenyl, the phenyl being capable of substitution one or several times by hydroxy, lower alkoxy, lower alkyl or halogen; a lower alkenyl or alkinyl group; a C3-C7-cyclo-alkyl group or a phenyl group possibly substituted by hydroxy, halogen, lower alkyl or lower alkoxy, and X and Y, which may be different or the same, represent hydrogen, lower alkyl, lower alkoxy, hydroxy, cyano, halogen, carboxyl, lower alkoxycarbonyl or carbamoyl, and Q represents non-ramified, saturated or unsaturated alkyl chain with 8-14 C atoms, which can be substituted, interrupted by hetero-atoms, and form part of a cyclic ...

MIXTURE OF MATRIX MATERIAL AND ORGANIC SEMICONDUCTOR CAPABLE OF EMISSION, USE THEREOF, AND ELECTRONIC COMPONENT CONTAINING THE MIXTURE

PROBLEM TO BE SOLVED: To provide a new material and a mixture of materials of an organic electronic component such as an electroluminescent element, and use thereof in a display based thereon. SOLUTION: The invention relates to a new mixture consisting of at least two materials, one material being used as a matrix material (for example, spirobifluorene represented by the figure) and the other as a material which is capable of emission and contains at least one element of an atomic number of 20 or larger. The mixture is used in the organic electronic component such as an electroluminescent element and a display. COPYRIGHT: (C)2012,JPO&INPIT ...

Способ получения триметил -бензохинона

Способ получения хинонов

Способ получения хиноновых производных

Изобретение касается хиноновых производных, в частности получения соединений общей ф-лы С(СНз)С(Х)-С(0)- CR2 CRi-C(0), где X CHR3-(CH2) (CH2)k m-R4; Ri и RajCHa. метокси или (Ri + )-rpynna -CH CH-CH C.H-; Rs-3,5,6- трйметил-1,4-бензохйнон-2-ил, тиенил, который замещен Ci-4-алкилом, фенил, который м,б. замещен Ci-4-элкокси, галогеном , трифторметилом, Ci-4-алкилом, имида- золилом, имидазолилметилом, нафтил; (0)OH, СНз, Ci-4-алкоксикарбонил, гид- роксиметил, который м.б, замещён аминокарбонилом; Z - группа а) ....... fT af ЬО B)VS Л г) cH}, n 2-8, m 0 или 1, k О или 1, которые обладают профилактическим действием против бронхиальной астмы, аллергии немедленного типа, различных воспалительных процессов, атеросклероза, шока от эндотоксина, связанного с бактериальной инфекцией, что может быть использовано в медицине. Цель - создание новых более активных веществ указанного класса. Синтез ведут окислением соединения ф-лы CfcHahCRe-CRi-CRa-CfC RsFCX, где Rs-H, СНз, Re-OH, Н, Метоксйгруппа. Новые ...

PROCESS FOR THE PRODUCTION OF 2,3,5-TRIMETHYLBENZOQUINONE

VERFAHREN ZUR REINIGUNG EINES OXIDATIONSREAKTIONSGEMISCHES.

PRODUCTION OF QUINONES

... 1,212,417. Quinones. IMPERIAL CHEMICAL INDUSTRIES Ltd. 2 April, 1969 [10 April, 1968], No. 17273/68. Heading C2C. Quinones are prepared by oxidizing an aromatic amine in a substantially waterimmiscible solvent, e.g. a hydrocarbon, chlorinated hydrocarbon or ether other than tetrahydrofuran, with an acidic aqueous solution of a pentavalent vanadium compound e.g. an alkali metal or ammonium meta vanadate in aqueous sulphuric acid. The spent vanadium reagent may be regenerated electrolytically. Examples disclose the preparation of benzoquinone from aniline and N-methyl aniline, of 2-methyl benzoquinone from o and m-toluidine and of naphthoquinone from 1-naphthylamine.

Compounds

PROCESS FOR PREPARING P-AND O-BENZOQUINONE DERIVATIVES

OXIDATION OF ORGANIC COMPOUNDS BY TELLUROXIDES

ADDUCTS FROM KETOVERBINDUNGEN AND ANIONS OF OXASAEUREN, PROCEDURE FOR THEIR PRODUCTION, THEIR USE AS WELL AS AZOKETOVERBINDUNGEN.

PROCEDURE FOR the PRODUCTION OF 2,3,5TRIMETHYLBENZOCHINON.

Bioreductive cytotoxic agents

A PROCESS FOR THE PREPARATION OF 2,3,5-TRIMETHYL-P-BENZOQUINONE

A process for the preparation of 2,3,5-trimethyl-p- benzoquinone by oxidation of 2,3,5- or 2,3,6- trimethylphenol using oxygen or a gas mixture containing oxygen in the presence of a two-phase liquid reaction medium composed of water and a neocarboxylic acid having 8 to 11 carbon atoms with a copper (II) halide-containing catalyst system at elevated temperature.

PROCESS FOR THE MANUFACTURE OF BENZOQUINONES

METHOD FOR THE PURIFICATION OF DICARBOXYLIC ACIDS PRODUCED BY FERMENTATION

Long-chain dicarboxylic acids, especially those produced by fermentation, are purified by a process involving dissolving the acid on a salt thereof in a lower aliphatic alcohol, tetrahydrofuran or aqueous solutions thereof, and removing insolubles from the solution so formed.

INHIBITORS OF HYDROXYPHENYLPYRUVATE DIOXYGENASE AND AN ASSAY FOR IDENTIFICATION OF INHIBITORS

... of the disclosure Detection method for identifying inhibitors There are described a method for enriching the anabolic p-hydroxyphenylpyruvate dioxygenases from plant tissues and a method by means of which the enzymatic activity of the enzyme can be measured in a simple manner without complete purification of the enzyme being necessary. The invention furthermore describes an assay system for identifying inhibitors of p-hydroxyphenylpyruvate dioxygenase from plants, in which an enriched HPPD from plants is incubated with a test substrate to be examined and the enzymatic activity of the enzyme is determined in comparison with the activity of the uninhibited enzyme. The invention furthermore describes the novel herbicidal active substances of the formula (I) (I) which were found using the assay method according to the invention.

Способ переработки технического лигнина с получением росторегулирующего вещества

Способ переработки технического лигнина с получением росторегулирующего вещества, включающий окисление водной суспензии лигнина азотной кислотой или окислами азота при температуре 50-120 °С с последующим выделением росторегулирующего вещества, отличающийся тем, что окисление проводят в течение 3-15 часов при подаче воздуха в количестве 0,003-0,1 дм3/мин на 1 г абсолютно сухого лигнина.

СПОСОБ ПОЛУЧЕНИЯ ТРИМЕТИЛГИДРОХИНОНА

Настоящее изобретение касается нового способа получения триметилгидрохинона (ТМГХ) посредством окисления триметилфенола (ТМФ). Оно касается, в частности, способа окисления триметилфенола посредством каталитической системы, образованной гетерополикислотами.

СПОСОБ ПОЛУЧЕНИЯ ТРИМЕТИЛГИДРОХИНОНА

Настоящее изобретение касается нового способа получения триметилгидрохинона (ТМГХ) посредством окисления триметилфенола (ТМФ). Оно касается в частности способа окисления триметилфенола посредством каталитической системы, образованной гетерополикислотами. Международная заявка была опубликована вместе с отчетом о международном поиске.

METHOD OF PRODUCING 2.6 - DIMETILBENZOKhINONA

Настоящее изобретение относится к усовершенствованному способу получения 2,6-диметилбензохинона (2,6-DMQ). The present invention relates to an improved method for producing 2,6-dimethylbenzoquinone (2,6-DMQ).

PROCESS FOR OXIDIZING PHENOLS TO QUINONES

TIMING VALVE FOR AN AUTOMATIC POWER TRANSMISSION

PROCESS FOR THE PREPARATION OF P-QUINONES

PROCESS FOR PREPARING AN INHIBITORY COMPOSITION COMPRISING A COMPOUND BASED ON AT LEAST TWO POLYMERIZATION-INHIBITING SOLIDS

NOVEL NATURAL ANTIBACTERIAL COMPOUND SEPARATED FROM ROOT OF PULSATILLA KOREANA NAKAI AND SEPARATION METHOD THEREOF

PURPOSE: A novel natural antibacterial compound separated from the root of Pulsatilla Koreana Nakai and its separation method are provided, wherein the compound is named after pulsaquinone and can be used as a lead compound for preparing the various active material. CONSTITUTION: The antibacterial compound named pulsaquinone is represented by the formula 1. The separation method comprises the steps of: vacuum-evaporating the methanol extract of the dry root of Pulsatilla Koreana Nakai to obtain the extract to collect the aqueous part; partitioning the extract with weak alkali buffer and ethyl acetate; controlling the aqueous part to be weak acidic; partitioning the aqueous part with ethyl acetate; eluting the active partition from the ethyl acetate extract by the silica gel adsorption chromatography with ethyl acetate and methanol with increasing the content of methanol gradually; eluting the active material from the active partition by the silica gel adsorption chromatography with ethyl ...

Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers

Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.

Process for preparing 2,3,5-trimethylbenzoquinone

PHOTOGRAPHIC ELEMENT

ХИНОНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, ОПОСРЕДУЕМЫХ Ape1

... 1. Соединение формулыили его фармацевтически приемлемая соль, где:Rпредставляет собой два заместителя, каждый из которых является независимо выбранным из группы, состоящей из водорода и алкоксигруппы, где оба Rне являются водородом одновременно; илиRпредставляет собой конденсированное арильное кольцо, которое, необязательно, является замещенным;R представляет собой водород или галоген, или алкил, гетероалкил, циклоалкил, циклогетероалкил, алкоксигруппу, гетероалкоксигруппу, циклоалкоксигруппу, циклогетероалкоксигруппу, алкилтиогруппу, гетероалкилтиогруппу, циклоалкилтиогруппу или циклогетероалкилтиогруппу, где каждая из перечисленных групп, необязательно, является замещенной;X представляет собой алкилен, алкенилен или алкинилен, каждый из которых, необязательно, является замещенным; иY представляет собой N(R)или NROR, где каждый R, необязательно, является выбранным из группы, состоящей из алкила, гетероалкила, циклоалкила и циклогетероалкила, каждый из которых, необязательно, является замещенным ...

Способ получения хиноновых производных

Изобретение относится к кетонам, в частности к получению хиноновых , т производных (R4)-(CH2)ft-Јz гДе( А --С C(R)-C(0)-C(RI)C(R)-C(0) при R, R .Ј - одинаковые или различные каждый метил, метоксн или вместе образуют R1- метил; пиридил, имидаэолил; . СООН. СН2ОН, CHiOCOCH3; Z, - -С СН-СН С -S; -С6Н4-; R С Cjf CH-CH C-CH CH, где R - метил, Н,п 0-6; k 0,1; которые проявляют ингибирующее действие синтетазы тромбоксана Аг, антагонизм к рецептору тромбоксана А ингибирование 5 липоксигеназы и ак-- цептирование активных кислородных частиц. Цель - разработка способа по- лучения соединений, обладающих ука эанным действием. Получение ведут реакцией окисляющего агента с срединени ем I, где (ORx)-C(R2) г C(R4)-CH(RT)CR3. 14 табл. 2 fe ...

QUINONE-DERIVATE ZUR VERBESSERUNG DER ZELLULARE BIOENERGIE

VERFAHREN ZUR REINIGUNG VON DURCH FERMENTATION ERZEUGTEN DICARBONSAEUREN

PROCESS FOR THE MANUFACTURE OF QUINONES

... 1364796 Quinones F HOFFMANN-LA ROCHE & CO AG 17 May 1972 [17 May 1971 17 Dec 1971] 23119/72 Heading C2C A process for the manufacture of quinones o the general formula in which at least one of the symbols R 1 , R 2 , R 3 and R 4 represents a methyl group and the otherf symbols represent a hydrogen atom or a methyl group comprises oxidizing a phenol of the general formula in which the symbols R 1 , R 2 , R 3 and R 4 have the significance given earlier and the symbol X represents a hydrogen, chlorine, bromine or iodine atom with the acid of oxygen or an oxygen containing gas in a solvent in the presence of copper and halogen ions as a catalyst and, if desired, in the presence of a complexing agent, but only in an amount up to a ratio of copper atoms : complexing agent molecules which is equal to 1 : 2. Complexing agents mentioned include akyl or phenyl derivatives of trivalent elements of the fifth main group of the periodic system, e.g. amines, phosphines and arsines. Examples describe the ...

CONNECTIONS, THE ONE MICHAEL ACCEPTOR SYSTEM CONTAINING, MARK IMIDE OR MALEIC ACID OF DERIVATIVES PREFERS, DIRECTLY OR INDIRECT WITH A CHROMOPHOREN A GROUP IS LINKED AND THEIR USE IN SUN PROTECTIVE AGENTS WITH LONG CONTINUOUS PROTECTION

PROCEDURE FOR THE PRODUCTION OF BENZOCHINONEN.

Procedure for the production of Chinonen

QUINONE DERIVATIVES FOR THE IMPROVEMENT OF THE ZELLULARE BIO ENERGY

Procedure for the production of Trimethyl p benzochinon

AGENT AND METHOD FOR COLORING KERATIN FIBERS CONTAINING 2-BENZOTHIAZOLINONE-HYDRAZONE AND QUINONE DERIVATIVES

PREPARATION OF 2,3,5-TRIMETHYL-P-BENZOQUINONE

Trimethyl-p-benzoquinone of the formula I (I) is prepared by a process wherein A. 2,5,6-trimethylcyclohex-2-en-1-one or 2,3,6-trimethyl-cyclohex-2-en-1-one is reacted with air or oxygen at from 0 to 150.degree.C in a virtually anhydrous low molecular weight alkanol in the presence of a catalytic amount of copper (I) oxide or copper(II) oxide and in the presence of from 1 to 10 moles of a hydrogen halide gas per mole of trimethylcyclohexenone, and thereafter B. the reaction mixture, which essentially contains 2,3,6-trimethylphenol and/or 4-halo-2,3,6-trimethylphenol, is mixed with an alkali metal alcoholate in an amount such that a sample, when moistened with water, has a pH of from 3 to 6, and is then reacted with air, pure oxygen or tert.-butyl hydroperoxide at from 0 to 150.degree.C, or wherein from 1 to 10 mole equivalents of a hydrogen halide gas per mole of substrate to be reacted are passed into a mixture containing a virtually anhydrous low molecular weight alkanol and a catalytic ...

CATALYTIC OXIDATION OF HYDROXY CONTAINING AROMATIC COMPOUNDS

The present invention relates to a process for the catalytic oxidation of hydroxy containing aromatic compounds to form the respective quinone compounds comprising contacting a hydroxy containing aromatic compound of the formula: (see fig. I) with a molecular oxygen containing gas in the presence of: (a) a catalytic amount of a cobalt (II) compound, (b) a primary aliphatic amine having the nitrogen atom attached to a tertiary carbon, and (c) an alcohol selected from the group consisting of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, 2,2,2-trifluoroethanol and benzyl alcohol, wherein X is selected from the group consisting of -OH, or (see fig. II) and R is individually selected from the group of radicals consisting of hydrogen, an alkyl having from about 1 to about 18 carbon atoms, an alkoxy having from about 1 to 8 carbon atoms, a phenyl and an aralkyl having 7 to 12 carbon atoms.

INHIBITORS OF HYDROXYPHENYLPYRUVATE DIOXYGENASE AND AN ASSAYFOR IDENTIFICATION OF INHIBITORS

Detection method for identifying inhibitors There are described a method for enriching the anabolic p-hydroxyphenylpyruvate dioxygenases from plant tissues and a method by means of which the enzymatic activity of the enzyme can be measured in a simple manner without complete purification of the enzyme being necessary. The invention furthermore describes an assay system for identifying inhibitors of p-hydroxyphenylpyruvate dioxy-genase from plants, in which an enriched HPPD from plants is incubated with a test substrate to be examined and the enzymatic activity of the enzyme is determined in comparison with the activity of the uninhibited enzyme. The invention furthermore describes the novel herbicidal active substances of the formula (I) (See formula I) which were found using the assay method according to the invention.

Mixtures of matrix materials and organic semiconductors capable of emission, use of the same and electronic components containing said mixtures

The present invention discloses mixtures of matrix materials and organic semiconductors capable of emission, use of the same and electronic components containing said mixtures. The invention relates to novel mixtures consisting of at least two substances, one substance being used as a matrix material and the other as a material which is capable of emission and contains at least one element having an atomic number larger than 20. The invention also relates to the use of said mixtures in organic electronic components such as electroluminescence elements and displays.

Preparation method of copper-based micro-/meso-porous catalyst

TIMING VALVE FOR AN AUTOMATIC POWER TRANSMISSION

Process for the preparation of trimethyl-benzoquinone

Para-benzoquinone prepn. by alkylphenol oidn. - in the presence of a cobalt di(salicylal)diimino-dipropylamine complex

The prepn. of p-benzoquinones (I) is carried out by oxidising an alkylphenol (II) with O2 or an O2-contg. gas in an org. solvent in the presence of a cobalt 3,3'-di(salicylal)-diimino-dipropylamine deriv. (III) and an amine (pref. with a pKa of 9-11). The reaction is pref. effected at 10-50 degrees C with an O2 partial pressure of =5 bar using 0.001-0.1 mole (III) per mole of (II) and 1 mole of amine per mole of (III). The alkylphenol (II) is pref. 2,3,5-trimethylphenol or 2,5-dimethylphenol. (III) is esp. Co 3,3'-di(salicylal)-diimino-dipropylamine or -dipropylmethylamine.

Method of preparation of derived from benzene

PROCEDE DE PREPARATION DE PARA- (OU ORTHO-) QUINONES ALCOXYLEES OU ARYLOXYLEES RESPECTIVEMENT A PARTIR DES HYDROQUINONES OU DES PYROCATECHOLS CORRESPONDANTS

PROCEDE DE PREPARATION D'UNE PARA- (OU ORTHO-) QUINONE ALCOXYLEE OU ARYLOXYLEE AU NIVEAU DU NOYAU PARA-QUINONIQUE OU ORTHO-QUINONIQUE, CARACTERISE EN CE QU'IL CONSISTE A OXYDER ET A ALCOXYLER OU ARYLOXYLER SIMULTANEMENT RESPECTIVEMENT L'HYDROQUINONE OU LE PYROCATECHOL CORRESPONDANT.

BLEACHABLE LIGHT?ABSORBING LAYERS FOR PHOTOGRAPHY

PREPARATIONS OF BENZOQUINONE AND DERIVATIVES THEREOF

FLAME RETARDANT SYSTEMS

PRODUCTION OF TRIMETHYL-p-BENZOQUINONE

２,３,６-트리메틸페놀의 산화에 의한 ２,３,５-트리메틸 벤조퀴논의 제조 방법

... 본 발명은, 적어도 할로겐화구리(II) 를 포함하는 촉매 또는 촉매계 존재 하, 2상 또는 다중상 반응 매질 중에서, 산소 또는 산소-함유 기체로 2,3,6-트리메틸페놀을 산화시켜, 2,3,5-트리메틸벤조퀴논을 포함하는 혼합물을 수득하는 단계를 포함하는, 2,3,5-트리메틸벤조퀴논 또는 2,3,5-트리메틸벤조퀴논을 포함하는 혼합물의 제조 방법으로서, 여기서 반응 매질이 6 개 이상, 바람직하게는 7 개 이상의 탄소 원자를 갖는 하나 이상의 2차 지방족 비고리형 알코올 및 물을 포함하는 것을 특징으로 하는 방법에 관한 것이다.

Process for the preparation of trimethyl-benzoquinone

A process for preparing trimethylbenzoquinone is provided which does not involve the formation of a sulphonic acid intermediate which comprises oxidising 2,3,6-trimethyl-phenol directly with manganese dioxide in an aqueous solution containing sulphuric acid in an amount up to 40% by weight.

PREPARATION OF BENZOQUINONES

Catalytic applications of mesoporous metallosilicate molecular sieves and methods for their preparation

A neutral templating route to mesoporous molecular sieves based on H-bonding and self-assembly between neutral primary amine or diamine surfactants (S°) and neutral inorganic precursors (I°) has been used to prepare hexagonal and lamellar mesoporous silicas with site isolated transition metal centers. This templating approach allows for the preparation of hexagonal or hexagonal-like mesoporous oxidation catalysts with large framework wall thickness of at least about 17 Å, small elementary particle size (<=400 Å), and unique combinations of framework-confined mesopores and textural mesopores while at the same time providing for facile recovery of the neutral template by simple solvent extraction. The templating of neutral metallosilicate precursors (I°) with neutral diamine surfactants (S°-S°) affords thermally stable pillared lamellar metallosilicates exhibiting complementary framework-confined microporosity and textural mesoporosity while at the same time also providing for template recovery ...

PREPARATION OF P-AND O-BENZOQUINONE DERIVATIVE AND ITS PREPARATION

PURPOSE: To obtain the corresponding benzoquinone derivative in high yield, safety and short time, by the oxidation of a p- and o-hydroquinone derivative with an aqueous hypohalite adjusted to a specific pH, in the presence of a quaternary ammonium salt. CONSTITUTION: A compound expressed by formulas I and II (R1WR8 are H, alkyl, aryl, etc., except when all R1WR4 and R5WR8 are H, and R1 and R2 and R3 and R4 may form a carbocyclic ring) is oxidized with an aqueous hypohalite adjusted to pH8W10, preferably in an equivalent amount of 2W8 times that of the hydroquinone derivative, in the presence of a quaternary ammonium salt preferably in an equivalent amount of 0.01W0.1 the hydroquinone derivative in an organic solvent, e.g. carbon tetrachloride, preferably at 0W35°C in the case of a compound expressed by formula I and at -20W0°C in the case of a compound expressed by formula II, to give compounds of formulas III and IV. COPYRIGHT: (C)1981,JPO&Japio ...

МОНОМЕРНАЯ КОМПОЗИЦИЯ И СПОСОБЫ ПОЛУЧЕНИЯ ФТОРИРОВАННОГО ПОЛИМЕРА

Изобретение относится к мономерной композиции и к способу получения фторированного полимера, с помощью которой может быть получен фторированный полимер с высокой молекулярной массой. Мономерная композиция включает особый циклический мономер и ингибитор полимеризации, при этом ингибитор полимеризации представляет собой ингибитор полимеризации, который удовлетворяет следующим требованиям: (a) представляет собой 6-членный ненасыщенный циклический углеводород, имеющий от 1 до 4 заместителей, (b) имеет в качестве заместителя по меньшей мере один тип заместителя, выбранный из группы, состоящей из трет-бутильной группы, метильной группы, изопропенильной группы, оксогруппы и гидроксигруппы, (c) в случае, когда ингибитор полимеризации имеет оксогруппу в качестве одного типа заместителя, один или более других заместителей, отличных от оксогруппы, представляют собой трет-бутильную группу и метильную группу, и (d) в случае, когда ингибитор полимеризации имеет гидроксигруппу в качестве заместителя, ...

TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH REDOX-ACTIVE THERAPEUTICS

Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD—not otherwise specified (PDD-NOS) or attention deficit/hyperactivity disorder (ADHD) comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds as disclosed herein. 113-. (canceled)1731-. (canceled)32. The method of claim 14 , wherein the bonds indicated with a dashed line are all single bonds.33. The method of claim 14 , wherein the bonds indicated with a dashed line are all double bonds.34. The method of claim 16 , wherein the bonds indicated with a dashed line are all single bonds.35. The method of claim 16 , wherein the bonds indicated with a dashed line are all double bonds.36. The method of claim 14 , wherein R claim 14 , R claim 14 , and Rare independently selected from the group consisting of H claim 14 , (C-C)alkyl claim 14 , and (C-C)alkoxy.37. The method of claim 14 , wherein R claim 14 , R claim 14 , and Rare independently selected from (C-C)alkyl.38. The method of claim 14 , wherein R claim 14 , R claim 14 , and Rare methyl.39. The method of claim 14 , wherein at least one of R claim 14 , R claim 14 , and Ris not methyl.40. The method of claim 14 , wherein Rand Rare methoxy claim 14 , and Ris methyl.41. The method of claim 32 , wherein the method is for treating the PDD claim 32 , wherein the PDD is autistic spectrum disorder (ASD).42. The method according to claim 33 , wherein the method is for treating the PDD claim 33 , wherein the PDD is autistic spectrum disorder (ASD).43. The method of claim 34 , wherein the method is for treating the PDD claim 34 , wherein the PDD is autistic spectrum disorder (ASD).44. The method according to claim 35 , wherein the method is for treating the PDD claim 35 , wherein the PDD is autistic spectrum disorder (ASD).45. The method according to claim 32 , wherein the method is ...

METHOD FOR PRODUCING 2,3,5-TRIMETHYL BENZOQUINONE BY OXIDATION OF 2,3,6-TRIMETHYLPHENOL

The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms. 115-. (canceled)16. A mixture comprising 2 ,3 ,5-trimethylbenzoquinone which has a copper content of less than 240 mg/kg.17. The mixture as claimed in claim 16 , wherein the mixture has a lithium content of less than 0.3 g/100 g.18. The mixture as claimed in claim 16 , wherein the mixture has a chlorine content of less than 0.5 g/100 g.19. The mixture as claimed in claim 16 , wherein the mixture has a copper content of less than 220 mg/kg.20. The mixture as claimed in claim 16 , wherein the mixture has a copper content from 210 to 220 mg/kg.21. The mixture as claimed in claim 17 , wherein the mixture has a copper content from 210 to 220 mg/kg.22. The mixture as claimed in claim 16 , wherein the mixture has a chlorine content of less than 0.42 g/100 g.23. The mixture as claimed in claim 16 , wherein the mixture has a chlorine content of from 0.26 g/100 g to 0.42 g/100 g.24. The mixture as claimed in claim 21 , wherein the mixture has a chlorine content of from 0.26 g/100 g to 0.42 g/100 g.26. The mixture according to claim 25 , wherein the mixture has a chlorine content of less than 0.5 g/100 g.27. The mixture according to claim 25 , wherein the mixture has a lithium content of less than 0.3 g/100 g.28. The mixture according to claim 25 , wherein the mixture has a copper content of less than 240 mg/kg.29. The mixture according to claim 26 , wherein the mixture has a lithium ...

TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH REDOX-ACTIVE THERAPEUTICS

Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD-not otherwise specified (PDD-NOS) or attention deficit/hyperactivity disorder (ADHD) comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds as disclosed herein. 131-. (canceled)37. A composition comprising a compound of and a pharmaceutically acceptable carrier.38. A composition comprising the compound of and a pharmaceutically acceptable carrier.39. A composition comprising the compound of and a pharmaceutically acceptable carrier.40. A composition comprising the compound of and a pharmaceutically acceptable carrier.41. A composition comprising a compound of and a pharmaceutically acceptable carrier.42. A food claim 32 , medical food claim 32 , functional food claim 32 , food supplement claim 32 , or dietary supplement comprising a compound of and a physiologically or nutritionally acceptable carrier claim 32 , adjuvant claim 32 , excipient claim 32 , buffer claim 32 , or diluent.43. A method of reducing a symptom associated with claim 32 , or for treating or suppressing a pervasive developmental disorder (PDD) or attention deficit/hyperactivity disorder (ADHD) in a patient in need of such treatment claim 32 , comprising administering to the patient a therapeutically or physiologically effective amount of a compound of .44. The method of claim 43 , wherein the method is for treating the PDD.45. The method of claim 44 , wherein the PDD is autistic disorder.46. The method according to claim 43 , wherein the method is for treating attention deficit/hyperactivity disorder (ADHD).47. The method according to claim 44 , wherein the PDD is Rett's disorder.48. A method of reducing a symptom associated with claim 36 , or for treating or suppressing a pervasive developmental disorder (PDD) or attention deficit/hyperactivity ...

METHOD OF FORMING PHENYLENE ETHER OLIGOMER

A phenylene ether oligomer is prepared by a process that includes partially converting 2,6-dimethylphenol to 3,3′,5,5′-tetramethyl-4,4′-dihydroxybiphenyl and/or 3,3′,5,5′-tetramethyldiphenoquinone, converting the residual 2,6 dimethylphenol to poly(2,6-dimethyl-1,4-phenylene ether) and any 3,3′,5,5′-tetramethyl-4,4′-dihydroxybiphenyl to 3,3′,5,5′-tetramethyldiphenoquinone, and reacting the poly(2,6-dimethyl-1,4-phenylene ether) and 3,3′,5,5′-tetramethyldiphenoquinone to form the phenylene ether oligomer. The preparation can be conducted without isolation of intermediates. 2. The method of claim 1 , wherein the alkylenediamine is selected from the group consisting of N claim 1 ,N′-di-(C-alkyl)ethylenediamines claim 1 , N claim 1 ,N claim 1 ,N′-tri-(C-alkyl)ethylenediamines claim 1 , N claim 1 ,N claim 1 ,N′N′-tetra-(C-alkyl)ethylenediamines claim 1 , N claim 1 ,N′-di-(C-alkyl)-1 claim 1 ,2-propylenediamines claim 1 , N claim 1 ,N claim 1 ,N′-tri-(C-alkyl)-1 claim 1 ,2-propylenediamines claim 1 , N claim 1 ,N claim 1 ,N′N′-tetra-(C-alkyl)-1 claim 1 ,2-propylenediamines claim 1 , N claim 1 ,N′-di-(C-alkyl)-1 claim 1 ,3-propylenediamines claim 1 , N claim 1 ,N claim 1 ,N′-tri-(C-alkyl)-1 claim 1 ,3-propylenediamines claim 1 , N claim 1 ,N claim 1 ,N′N′-tetra-(C-alkyl)-1 claim 1 ,3-propylenediamines claim 1 , and combinations thereof.3. The method of or claim 1 , wherein the alkylenediamine is selected from the group consisting of N claim 1 ,N′-di-tert-butylethylenediamine claim 1 , N claim 1 ,N claim 1 ,N′ claim 1 ,N′-tetraethylethylenediamine claim 1 , N claim 1 ,N claim 1 ,N′ claim 1 ,N′-tetramethylethylenediamine claim 1 , N claim 1 ,N′-diethyl-N claim 1 ,N′-dimethylethylenediamine claim 1 , N claim 1 ,N′-diethylethylenediamine claim 1 , N claim 1 ,N′-dimethylethylenediamine claim 1 , N claim 1 ,N claim 1 ,N′ claim 1 ,N′-tetramethyl-1 claim 1 ,3-butylenediamine claim 1 , and combinations thereof.4. The method of any one of - claim 1 , wherein the reaction of the 2 ...

Способ получения 2, 3, 5-триметилбензохинона при помощи окисления 2, 3, 6-триметилфенола

А 2016103145 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) 1] хх < д < Хх < РИ "’ 23: (50) МПК С07С 46/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2016103145, 25.06.2014 (71) Заявитель(и): БАСФ СЕ (ОЕ) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): 02.07.2013 ЕР 13174688.5; ДЭН Рихард (ОЕ), 02.07.2013 95$ 61/841,946 КЛАУС Михаель (ОЕ), (43) Дата публикации заявки: 07.08.2017 Бюл. № 22 я АНП. Е (85) Дата начала рассмотрения заявки РСТ на ТЕЛЕС Йоахим Энрике (РЕ) национальной фазе: 02.02.2016 (86) Заявка РСТ: ЕР 2014/063425 (25.06.2014) (87) Публикация заявки РСТ: УГО 2015/000767 (08.01.2015) Адрес для переписки: 105064, Москва, а/я 88, "Патентные поверенные Квашнин, Сапельников и партнеры" (54) СПОСОБ ПОЛУЧЕНИЯ 2, 3, 5-ГРИМЕТИЛБЕНЗОХИНОНА ПРИ ПОМОЩИ ОКИСЛЕНИЯ 2, 3, 6-ТРИМЕТИЛФЕНОЛА (57) Формула изобретения 1. Способ получения 2,3,5-триметилбензохинона или смеси, содержащей 2,3,5- триметилбензохинон, включающий в себя следующую стадию: (1) окисление 2,3,6-триметилфенола до 2,3,5-триметилбензохинона с помощью кислорода или кислородсодержащего газа в двух- или многофазной реакционной среде в присутствии катализатора или каталитической системы, содержащей по меньшей мере галогенид меди (ПП), так что образуется смесь, содержащая 2,3,5- триметилбензохинон, отличающийся тем, что реакционная среда содержит воду и по меньшей мере один вторичный алифатический ациклический спирт, имеющий 6 или более, предпочтительно 7 или более, атомов углерода. 2. Способ по п. 1, отличающийся тем, что катализатор или каталитическая система содержит хлорид меди (П). 3. Способ по п. 1 или 2, отличающийся тем, что катализатор или каталитическая система, кроме того, содержит по меньшей мере один галогенид щелочного металла, предпочтительно хлорид лития. 4. Способ по п. 1 или 2, отличающийся тем, что реакционная среда содержит 3- гептанол. 5. Способ по п. 1 или 2, отличающийся тем, что этот способ проводится в Стр.: 1 па ЗУ ГОС У А ...

Preparation of 2,3,5-trimethylbenzoquinone

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Preparation of 3,3'5,5'-tetratertiary butyl diphenoquinone

Oxidative coupling products of 2,6-ditertiary butyl phenol are formed by contacting the 2,6-ditertiary butyl phenol with an oxygen-containing gas in the presence of a heterogeneous oxidative coupling catalyst in methanol.

Method for the preparation of 2,3,5-trimethylbenzoquinone

본 발명은 2,3,5-트리메틸벤조퀴논의 제조방법에 관한 것으로, 좀 더 상세하게는 용매 및 산화제 존재하에서 2,3,5-트리메틸페놀 또는 2,3,6-트리메틸페놀을 산화촉매로 붕소화합물을 사용하여 반응시켜 2,3,5-트리메틸벤조퀴논을 제조하는 방법에 관한 것이다. 본 발명에 사용된 산화제와 촉매는 상업적으로 손쉽게 구입할 수 있는 화합물인바, 본 발명을 통해서 2,3,5-트리메틸벤조퀴논을 경제적으로 대량생산이 가능하게 하는 효과가 있다. The present invention relates to a method for preparing 2,3,5-trimethylbenzoquinone, and more particularly, to 2,3,5-trimethylphenol or 2,3,6-trimethylphenol in the presence of a solvent and an oxidizing agent. It relates to a method for producing 2,3,5-trimethylbenzoquinone by reacting with a boron compound. The oxidizing agent and catalyst used in the present invention are commercially available compounds, and thus, the present invention has the effect of enabling economically mass production of 2,3,5-trimethylbenzoquinone.

Patent JPH0451536B2

Method for producing 2,3,5-trimethylbenzoquinone by oxidation of 2,3,6-trimethylphenol

Patent FR2249062B1

Process for oxidizing a phenol to a p-benzoquinone

ABSTRACT Phenol or a substituted phenol is oxidized to the corresponding benzoquinone or substituted benzoquinone in a nitroalkane solvent in the presence of a copper ion catalyst promoted with a base selected from alkali metal phenoxides, and secondary or tertiary lower alkyl amines.

Trimethyl-para-benzoquinone prepn. - by oxidn. of 2,3,5-trimethyl-phenol in presence of complex salts of cobalt and Schiff's bases

Trimethyl-p-benzoquinone (II) is prepd. by oxidation of 2,3,5-trimethylphenol, with O2 or a gas contng. O2 in an inert org. solvent in the presence of complex salts of Co and Schiffs bases, of formula (I):- (where R1, R2, R3 = same or different are H or 1-4C 1 alkyl; R2 and R3 together with the C atoms to which they are attached may form a benzene ring (opt. substd. by halo, NO2, 1-4C alkyl or 1-4C alkoxy); R4 = divalent 2-15C hydrocarbyl or a 4-10C alkyl interrupted by hetero-atom(s) such as O or N). (II) is an inter. for trimethylhydroquinone which is a precursor for Vitamin E. Process is suitable for industrial scale and gives good yields (up to about 80%) of (II).

Patent FR2449667B1

Patent FR2408570B1

Patent FR2268779B1

Patent FR2401896B1

4-hydroxytetrahydropyran-2-one derivatives

4-hydroxytetrahydropyran-2-one derivatives with general formula (I) are useful as cholesterol reducing agents as well as lipid reducing agents, serving as inhibitors of HMG-CoA reductase, and capable of inhibiting the biosynthesis of peroxidized lipids, and therefore effective for curing arteriosclerosis: ##STR1## wherein R 1 represent hydrogen or a 2-tetrahydropyranyl group; R 2 and R 3 each represent hydrogen or an alkyl group having 1 to 6 carbon atoms; R 4 represents hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an aryl group, an aralkyl group, an acyl group, an aroyl group or a substituted sulfonyl group; A represents --CH 2 CH 2 --, or --CH═CH--; and n is an integer of 1 or 2, and intermediates for synthesizing the 4-hydroxytetrahydropyran-2-one derivatives are disclosed.

QUINONES BY THALLIC OXIDATION OF PHENOLS

Method for preparing 2-methyl-1,4-naphthoquinone

FIELD: organic chemistry, organic synthesis, chemical technology. SUBSTANCE: invention relates to a method for synthesis of 2-methyl-1,4-naphthoquinone (menadione, vitamin K 3 ) that is used broadly in medicinal practice and animal husbandry. Method for synthesis of 2-methyl-1,4-naphthoquinone involves oxidation of 2-methyl-1-naphthol with oxygen or oxygen-containing gas in medium of a low-polar or nonpolar organic solvent or in 2-methyl-1-naphthol melt at intensive stirring, under pressure 1 atm, not less, and temperature 20°C, not less. Method provides simplifying technology and preparing the end product of high purity and high yield. EFFECT: improved preparing method. 4 cl, 1 tbl, 17 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 278 106 (13) C1 (51) ÌÏÊ C07C 50/12 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2005108448/04, 28.03.2005 (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 28.03.2005 (45) Îïóáëèêîâàíî: 20.06.2006 Áþë. ¹ 17 (73) Ïàòåíòîîáëàäàòåëü(è): Èíñòèòóò êàòàëèçà èì. Ã.Ê. Áîðåñêîâà Ñèáèðñêîãî îòäåëåíè Ðîññèéñêîé Àêàäåìèè íàóê (RU) ãàçîì â ñðåäå ìàëîïîë ðíîãî èëè íåïîë ðíîãî îðãàíè÷åñêîãî ðàñòâîðèòåë èëè â ðàñïëàâå 2ìåòèë-1-íàôòîëà ïðè èíòåíñèâíîì ïåðåìåøèâàíèè ïðè äàâëåíèè íå íèæå 1 àòì è òåìïåðàòóðå íå íèæå 20°Ñ. Òåõíè÷åñêèé ðåçóëüòàò - óïðîùåíèå òåõíîëîãèè ñ ïîëó÷åíèåì öåëåâîãî ïðîäóêòà âûñîêîé ÷èñòîòû ïðè åãî âûñîêîì âûõîäå. 3 ç.ï. ôëû, 1 òàáë. R U 2 2 7 8 1 0 6 (57) Ðåôåðàò: Èçîáðåòåíèå îòíîñèòñ ê îðãàíè÷åñêîìó ñèíòåçó, à èìåííî ê ñïîñîáó ïîëó÷åíè 2-ìåòèë-1,4íàôòîõèíîíà (ÌÍÕ, ìåíàäèîíà, âèòàìèíà Ê3), êîòîðûé øèðîêî ïðèìåí åòñ â ìåäèöèíñêîé ïðàêòèêå è æèâîòíîâîäñòâå. 2-Ìåòèë-1,4íàôòîõèíîí ïîëó÷àþò ïóòåì îêèñëåíè 2-ìåòèë-1íàôòîëà êèñëîðîäîì èëè êèñëîðîäñîäåðæàùèì Ñòðàíèöà: 1 RU C 1 C 1 (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß 2-ÌÅÒÈË-1,4-ÍÀÔÒÎÕÈÍÎÍÀ 2 2 7 8 1 0 6 Àäðåñ äë ïåðåïèñêè: 630090, ã.Íîâîñèáèðñê, ïð. Àêàä. Ëàâðåíòüåâà, 5, Èíñòèòóò êàòàëèçà èì. Ã.Ê. Áîðåñêîâà, ...

Method for producing 2,3,5-trimethyl benzoquinone by oxidation of 2,3,6-trimethylphenol

本发明涉及制备2,3,5-三甲基苯醌或包含2,3,5-三甲基苯醌的化合物的方法，所述方法包括以下步骤：将2,3,6-三甲基苯酚在两相或多相反应介质中在包含至少一种铜(II)卤化物的催化剂或催化剂体系的存在下用氧气或含氧气体氧化成包含2,3,5-三甲基苯醌的混合物，其特征在于反应介质包含水和至少一种具有6个或更多，优选7个或更多碳原子的仲脂族无环醇。

Process for the manufacture of quinones

Manufacture of ppbenzoquinone

PARA-BENZOQUINONE PREPARATION PROCESS

Procédé de préparation de tara-benzoquinone par oxydation du phénol par l'oxygène moléculaire en présence d'ions cuivreux ou cuivriques et d'un réducteur organique. Process for the preparation of tara-benzoquinone by oxidation of phenol with molecular oxygen in the presence of cuprous or cupric ions and of an organic reducing agent.

Method of producing n-benzoquinone

p-Benzoquinone is prepared by oxidizing phenol with molecular oxygen or with a gas in which oxygen is present, in the liquid phase, in the presence of cuprous or cupric ions. The improvement resides in carrying out the reaction in the presence of a metal, in the metallic form, which is selected from the group consisting of nickel, iron, tin, cobalt, chromium, molybdenum, magnesium and copper. The resultant p-benzoquinone is useful as an industrial source of hydroquinone, which is employed in photography.

Method for producing 2,3,5-trimethyl benzoquinone by oxidation of 2,3,6-trimethylphenol

The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two-or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (ll)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.

Process for the preparation of 2,3,5-trimethylbenzoquinone

A process for preparing 2,3,5-trimethylbenzoquinone (TMBQ) from 2, 3, 6-trimethylphenol (TMP), which comprises contacting TMP with oxygen or oxygen-containing gas in an aqueous solution of a catalyst comprising a copper halogeno complex represented by the general formula (I) and an alkali metal halide; said contact reaction of TMP with the oxygen or the oxygen-containing gas being carried out semi-batchwise while continuously adding a solution of TMP in a specified alcohol to the aqueous solution of the catalyst to which a specified alcohol, cupric hydroxide, cuprous chloride or a mixture thereof is previously added. The present process yields various advantages as follows: (1) TMBQ can be produced with high selectivity, (2) TMBQ can be easily separated from the reaction mixture, (3) The amount of the catalyst consumed can be greatly reduced, and (4) Reuse of the catalyst can be easily accomplished.

PARA-BENZOQUINONE PREPARATION PROCESS

Process for the preparation of para-benzoquinone

: Procédé de préparation de para-benzoquinone par oxydation du phénol par l'oxygène moléculaire en présence d'ions cuivreux ou cuivriques et d'un réducteur organique.

Process for preparing ppbenzoquinone

Ketone esp. cyclohexanone prepn. from olefinic cpd. with oxidant recovery

Catalytic oxidation of hydroxy containing aromatic compounds

The present invention relates to a process for the catalytic oxidation of hydroxy containing aromatic compounds to form the respective quinone compounds comprising contacting a hydroxy containing aromatic compound of the formula: (see fig. I) with a molecular oxygen containing gas in the presence of: (a) a catalytic amount of a cobalt (II) compound, (b) a primary aliphatic amine having the nitrogen atom attached to a tertiary carbon, and (c) an alcohol selected from the group consisting of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, 2,2,2-trifluoroethanol and benzyl alcohol, wherein X is selected from the group consisting of -OH, or (see fig. II) and R is individually selected from the group of radicals consisting of hydrogen, an alkyl having from about 1 to about 18 carbon atoms, an alkoxy having from about 1 to 8 carbon atoms, a phenyl and an aralkyl having 7 to 12 carbon atoms.

Preparation of 2,3,5-trimethylbenzoquinone

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for the preparation of trimethyl-p-benzoquinone

Method for the preparation of 2,3,5-trimethylbenzoquinone

Patent JPS4840341B1

PROCESS FOR PREPARING TRIMETHYL P-BENZOQUINONE.

A kind of copper catalyst of Polymer-supported and preparation and application

本发明描述了一种聚合物负载的铜催化剂及制备和应用，其特征在于载体为邻菲罗啉与芳基化合物交联的聚合物，活性组分为金属铜，铜负载于邻菲罗啉与芳基化合物交联聚合物上，其中铜的质量负载量为1％‑10％。其制备方法为将邻菲罗啉与芳基化合物以及二甲氧基甲烷在强酸催化下合成交联聚合物，并进一步将铜的化合物铜负载在聚合物上，得到该聚合物负载的铜催化剂。应用该负载金属铜催化剂可用于催化氧气氧化2，3，6‑三甲基苯酚制备2，3，5‑三甲基‑1，4‑苯醌。该催化剂制备方法简单，具有较高的活性和选择性，稳定性好，催化剂可实现多次重复使用，有很好的工业前景。

PROCESS FOR OXIDATION OF PHENOLE AND LAKYL-PHENOLS TO CORRESPONDING P-BENZOQUINONES

PROCESS FOR THE PRODUCTION OF P-BENZOQUINONE

Process for the production of 2,3,5-trimethylbenzoquinone

Process for the preparation of alkoxylated or aryloxylated para- (or ortho-) quinones respectively from the corresponding hydroquinones or pyrocatechols.

Process for the preparation of a para- (or ortho-) quinone which is alkoxylated or aryloxylated at the para-quinone or ortho-quinone nucleus, characterised in that it consists in oxidising and simultaneously alkoxylating or aryloxylating the corresponding hydroquinone or pyrocatechol, respectively.

Process for the oxidation of hydroquinone to p.benzoquinone

PROCEDURE FOR THE PREPARATION OF PARA-KINONIC OR ORTHO-KINONE DERIVATIVES, POSSIBLY ALCOXYLATED OR ARYLOXYLATED, RESPECTIVELY STARTING FROM THE CORRESPONDING HYDROKINONIC OR PYROCATECHIC DERIVATIVES

Process for the oxidation of olefins

Process for the manufacture of quinones

Process for the preparation of 2,3,5-trimethyl-p-benzoquinone

Verfahren zur Herstellung von 2,3,5-Trimethyl-p-benzochinon durch Oxidation von 2,3,5- oder 2,3,6-Trimethylphenol mittels Sauerstoff oder eines Sauerstoff enthaltenden Gasgemisches in Gegenwart eines zweiphasigen flüssigen Reaktionsmediums, bestehend aus Wasser und einer Neocarbonsäure mit 8 bis 11 C-Atomen mit einem Kupfer(II)halogenid enthaltenden Katalysatorsystem bei erhöhter Temperatur. A process for the preparation of 2,3,5-trimethyl-p-benzoquinone by oxidation of 2,3,5- or 2,3,6-trimethylphenol by means of oxygen or a gas mixture containing oxygen in the presence of a two-phase liquid reaction medium consisting of water and a neocarboxylic acid having 8 to 11 carbon atoms with a copper (II) halide-containing catalyst system at elevated temperature.

Reactivation of copper salt phenol oxidation catalysts

1482369 Catalyst reactivation GOODYEAR TIRE & RUBBER CO 19 Feb 1975 [13 March 1974] 6984/75 Heading B1E [Also in Division C2] A phenol oxidation catalyst selected from copper I or copper II halides, cyanates, thiocyanates or cyanides which has become deactivated by use in the oxidation of phenol in methanol solution by precipitation of the salt in the form of an insoluble, inactive complex is reactivated by (i) separating the inactive complex from the reaction solution, (ii) adding 0.001-1.0 mole/gm complex of at least one acid selected from sulphuric, hydrochloric, nitric, trifluoroacetic, phosphoric, perchloric and toluene sulphonic acids, and (iii) heating the mixture, if necessary, until the complex dissolves. Methanol may be added to the mixture in addition to acid. The Examples relate to treatment of deactivated copper (II) chloride catalyst.

Patent FR2272068B1

Trimethyl-p-benzoquinone preparation process

PROCESS FOR PREPARING P-BENZOCHINONE

METHOD FOR THE PRODUCTION OF ANY ALKOXYLATED OR ARYLOXYLATED PARA-CHINONE OR ORTHO-CHINONE DERIVATIVES FROM THE CORRESPONDING HYDROQUINONE OR BRENZ CATECHINE DERIVATIVES

Patent FR2272068A1

Process for preparing 2,3,5-trimethylbenzoquinone

2，3，5-三甲基苯醌是在氯化铜和氯化锂组成的催化剂存在下，在芳香烃和C 1-4 低级脂肪族醇组成的溶剂混合物中使2，3，6-三甲基苯酚氧化制得的。

Process of preparing p-benzoquinone

Process for the preparation of 2,6-di-tertiary-butyl-hydroquinone

PROCESS FOR THE PREPARATION OF QUINONES

Patent JPH0460098B2

OXIDATION OF MONOHYDROXY ARYL COMPOUNDS TO QUINONES-1,4

PROCEDURE FOR PREPARING P-BENZOQUINONE.

Patent JPS5059342A

Process for the preparation of benzoquinones by oxidation of phenols

Method for producing quinones

PROCEDURE FOR THE PREPARATION OF PARA-KINONIC OR ORTHO-KINONIC DERIVATIVES, EVENTUALLY ALCOXYLATED OR ARYLOXYLATED, RESPECTIVELY STARTING FROM THE CORRESPONDING HYDROKINONIC OR PYROCATECHIC DERIVATIVES.

No translation available

La p-benzoquinone est préparée par oxydation du phénol par l'oxygène moléculaire ou un gas qui en contient, en phase liquide en présence d'ions cuivreux ou cuivriques. La réaction est conduite en présence d'un métal à l'état métallique choisi dans le groupe constitué par le nickel, le fer, l'étain, le cobalt, le chrome, le molybdène, le magnésium et le cruivre. Le procédé de l'invention permet l'utilisation de réacteurs en métal émaillé ou en tantale pour conduire la réaction.

Patent JPS5059341A

METHOD FOR PREPARING TRIMETHYL-P-BENZOQUINONE

Process for the manufacture of quinones

Patent FR2249062A1

Patent FR2535713B1

PROCESS FOR PREPARING CHINONES.

NOVEL COPPER CHLORIDE SELECTIVE OXIDIZING SYSTEM AND ITS APPLICATION TO OXIDATION OF PHENOLIC DERIVATIVES FOR THE OBTAINING OF CORRESPONDING QUINUNIC DERIVATIVES

NOUVEAU SYSTEME OXYDANT SELECTIF CONSTITUE PAR LA COMBINAISON DE CHLORURE CUIVREUX, D'ACETONITRILE ET D'OXYGENE MOLECULAIRE. CE SYSTEME EST UTILE NOTAMMENT POUR L'OXYDATION DE PHENOLS EN QUINONES. NEW SELECTIVE OXIDIZING SYSTEM CONSTITUTED BY THE COMBINATION OF COPPER CHLORIDE, ACETONITRILE AND MOLECULAR OXYGEN. THIS SYSTEM IS USEFUL IN PARTICULAR FOR THE OXIDATION OF PHENOLS TO QUINONES.

Process for producing 2,3,5-trimethylbenzoquinone

Yield-efficient process for the production of highly pure 2-methyl-1,4-naphthoquinone and its derivatives

The present invention concerns a process for the production of 2-methyl-1,4-naphthoquinone and its derivatives, comprising the following steps: a) oxidizing 2-methyl-naphthalene (2-MNA) to achieve an organic phase containing 2-methyl-naphthoquinone (2-MNQ) and 6-methyl-naphthoquinone (6-MNQ); b) subjecting said organic phase to treatment with an aqueous solution of a bisulfite salt to extract preferentially the 6-MNQ isomer from the organic phase; c) separating said organic phase from the aqueous phase: d) optionally removing interfering bisulfite ions from said aqueous phase e) raising the pH of said aqueous phase to higher than 8.5 in the presence of a solvent resulting in an organic phase containing 2-MNQ; f) isolating said 2-MNQ from said organic phase.

Process for preparing para-quinone and ortho-quinone derivatives

Process for the preparation of para-benzoquinones

1. Process for the preparation of para-benzoquinones by the oxidation of phenol, or of phenols which are monosubstituted or polysubstituted in the ortho- and/or metaposition, with molecular oxygen or a gas containing molecular oxygen, the reaction being carried out in an organic solvent, in the presence of cuprous or cupric ions, characterized in that the reaction is carried out in a ketone, as the solvent, and also in the presence of carboxylate or phenate ions.

Process for the manufacture of quinones

PROCESS FOR THE PRODUCTION OF 2,3,5-TRIMETHYL-p-BENZOCHINONE

Postupak za proizvodnju 2,3,5-trimetil-p-benzohinona oksidacijom 2,3,5- ili 2,3,6-trimetilfenola, pomoću kiseonika ili jedne smeše gasa sa sadržajem kiseonika u prisustvu dvofazne tečne reakcione sredine od smeše vode i neokarbonske kiseline sa 8 do 11 C-atoma i uz primenu jednog katalizatora bar sa sadržajem halogenida bakra (II), na povišenoj temperaturi.[Process for the production of 2,3,5 -trimethyl-p-benzochinione by oxidation of 2,3,5 or 2,3,6 -trimethyl phenol, by means of oxigen or mixture of gas with the content of oxygen in the presence of two phase fluid reaction mixture of water and neocarbonic acid with 8 to 11 C-atoms and at least with the content of copper halogenide (II) at raised temperature.

METHOD FOR PREPARING TRIMETHYL-P-BENZOQUINON VEDOXIDATION OF 2,3,6-TRIMETHYLPHENOL

Catalytic oxidation of hydroxy containing aromatic compounds

efficient process for the production of high purity 2-methyl-1,4-naphthoquinone and its derivatives.

processo com rendimento eficiente para a produção de 2 - metil -1,4 - naftoquinona com alta pureza e de seus derivados. a presente invenção descreve um processo para a produção de 2-metil-1,4 naftoquinona e seus adutos de bisssulfito, compreendendo as seguintes etapas: a) oxidação do 2-metil-naftaleno (2-mna) para obter uma fase orgânica contendo 2-metil-naftoquinona (2-mnq) e 6-metil-naftoquinona; b) exposição da referida fase orgânica ao tratamento com uma solução aquosa de um sal de bissulfito para extrair preferencialmente o isômero 6-mnq da fase orgânica; c) separação da referida fase orgânica da fase aquosa; d) exposição da fase orgãnica da etapa do processo c) a uma segunda etapa de bissulfitação com uma solução aquosa de um sal bissulfito, resultando em uma fase orgânica contendo 2-mna e traços de 2-mnq, e uma fase aquosa contendo 2-msb e traços de 6-msb; e) remoção opcional dos íons de bissulfito interferentes da fase aquosa do processo da etapa c); f) aumento do ph da fase aquosa da etapa c) ou e) para mais de 8,5 na presença de um solvente resultando em uma fase orgânica contendo 2-mnq; g) combinação da fase orgânica da etapa f) com a fase orgânica sendo tratada na etapa do processo d); h) exposição da fase orgãnica a um novo ciclo da etapa d) de volta a etapa a) para ser utilizada como solvente na reação de oxidação do 2-mna. efficient process for the production of high purity 2 - methyl - 1,4 - naphthoquinone and its derivatives. The present invention describes a process for the production of 2-methyl-1,4 naphthoquinone and its bisulfite adducts, comprising the following steps: a) Oxidation of 2-methyl naphthalene (2-mna) to obtain an organic phase containing 2 methyl naphthoquinone (2-mmq) and 6-methyl naphthoquinone; b) exposing said organic phase to treatment with an aqueous solution of a bisulfite salt to preferentially extract the 6-mmol isomer from the organic phase; c) separating said organic phase from the aqueous phase; d) exposing the organic ...

Photographic recording material

2,3, the preparation method of 5-trimethylbenzoquinone

2，3，5-三甲基苯醌是在氯化铜和氯化锂组成的催化剂存在下，在芳香烃和C 1-4 低级脂肪族醇组成的溶剂混合物中使2，3，6-三甲基苯酚氧化制得的。

酚类化合物的光氧化

本发明涉及将酚类化合物光氧化成相应的醌型化合物，其中使用具有可见光谱的高波长范围的光，使用在水与醇的溶剂混合物中的亚甲基蓝作为光敏剂。

2,3,6-三甲基苯酚的光氧化

本发明涉及光氧化2,3,6‑三甲基苯酚以得到2,3,5‑三甲基苯醌，其中使用具有可见光谱的高波长范围的光，在水与醇的溶剂混合物中使用亚甲基蓝作为光敏剂。

Procedimento per la preparazione di para-benzochinone.

Process for producing condensation products of 1,4-naphthohydroquinones

Procedimento per preparare p-benzochinone.

双催化体系制备对苯醌化合物的方法

本发明属于有机合成技术领域，涉及一种对苯醌化合物的制备方法，包括以下步骤：1）将苯酚化合物、过渡金属盐催化剂、酸性离子液体和溶剂依次加入高压反应釜，充入氧气至指定压力，加热至指定温度并持续搅拌，反应0.5‑5小时；2）反应结束后将催化剂从反应体系分离并蒸出溶剂，剩余固体经溶剂洗涤后再汽提得到对苯醌化合物；本发明方法在保证了高转化率、高选择性的同时，有效降低过渡金属催化剂用量的，且离子液体催化剂可多次循环使用，实现了低排放、绿色环保的生产工艺，经济性也大大提高，适合工业化生产。

Verfahren zur herstellung von 2,3,5-trimethylbenzochinon durch oxidation von 2,3,6-trimethylphenol

フェノール化合物の光酸化

本発明は、可視スペクトルの高い波長の範囲の光を使用して、水とアルコールの溶媒混合物中で光増感剤としてメチレンブルーを使用するフェノール化合物のそれぞれのキノイド化合物への光酸化に関する。【選択図】なし