Способ получения (IR)-фенотрина

Изобретение касается производства сложных эфиров хризантемовой кислоты, в частности получения 3-феноксибензилового эфира (IR)-хризантемовой кислоты [((IR)-фенотрина], являющегося действующим веществом инсектицидного препарата для сельского хозяйства. Цель - повышение выхода целевого продукта. Процесс ведут последовательной обработкой (IR)-2,2-диметил-3-(2Ъ-оксопропил)-циклопропан-1-карбоновой кислоты гидрокарбонатом калия, 3-феноксибензилхлоридом, метилмагнийиодидом и дегидратацией в присутствии п-толуолсульфокислоты при нагревании. Выход 57%. Исходную кетокислоту получают известным двухстадийным способом из доступного сырья - 3-карена с общим выходом 45%. Общий выход целевого продукта 3-карена 26%, что на 12% выше известного.

New derivatives of the carboxylic acid cyclopropane their preparation, their application to the fight against the parasites of the plants, of the animals and the buildings, the compositions containing them and new intermediaries obtained.

CYCLOPROPAN CARBOXYLSAEURE DERIVATIVES, YOUR PRODUCTION AND APPLICATION WITH THE FIGHT AGAINST PARASITS AGAINST PLANTS, ANIMALS AND RESTAURANTS, YOUR COMPOSITIONS AND INTERMEDIATE PRODUCTS.

CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES; PROCESS FOR PREPARING THE SAME AND THEIR USE FOR CONTROLLING PLANT AND INDOOR PESTS; COMPOSITIONS THEREOF AND NEW INTERMEDIATES PRODUCED

... : L' invention concerne les composés (I') : (I') où la double liaison est E ou Z, A' est un reste d'alcool et R est un alcoyl (C1-C18) substitué par un ou plusieurs groupements fonctionnels identiques ou différents ou un aryl (C6-C14) ou un hétérocycle, éventuellement substitué par un ou plusieurs groupements fonctionnels identiques ou différents. L'invention concerne également la préparation des composés (I'), leur application à la lutte contre les parasites des végétaux et des locaux, les compositions les renfermant et les nouveaux intermédiaires obtenus.

New cyclopropanecarboxylic acid derivatives, process for their preparation and their application in combating parasites

Способ получения эфиров-производных циклопропанкарбоновой кислоты

Изобретение касается производных циклоалифатических кислот, в частности получения эфиров замещенной хщклопропанкарбоновой кислоты общей ФОРМУЛЫ R-0-C(0) -СН-С(СН)г-СН-С(0)ОА , где R-C,-C4.алкил , замещенный хлором или фтором; А - (1S) ( циано-З-феноксибензил; ...

VINYL CARBOXYLATE DERIVATIVES OF EYDOPROPANE CARBOXYLIC ACID ESTERS AND USE AS PESTICIDES

СПОСОБ ПОЛУЧЕНИЯ ЭФИРОВ ПРОИЗВОДНЫХ ЦИКЛОПРОПАНКАРБОНОВОЙ КИСЛОТЫ

Предметом изобретения является способ получения эфиров - производных циклопропанкарбоновой кислоты. Он основан на взаимодействии со спиртом в органическом растворителе при комнатной температуре в присутствии основания. В качестве основания используется пиридин или диметиламинопиридин и при необходимости дициклогексилкарбодиимид.

NEW DERIVATIVES OF THE CARBOXYLIC ACID CYCLOPROPANE, THEIR METHOD OF PREPARATION, AND THEIR APPLICATION TO THE FIGHT AGAINST THE PARASITES

PROCESSES OF COMPOSITE PREPARATION, APPLICATION OF SAID COMPOSITES, AND COMPOSITIONS DESTINED TO THE COMBAT OF PARASITES

CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE

Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.

АЛЬТЕРНАТИВНЫЕ СПОСОБЫ СИНТЕЗА ИНГИБИТОРОВ РЕНИНА И ИХ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ

Настоящее изобретение относится к способам синтеза соединений формулы (А), где R1 означает галоген, C1-С6галогеналкил, С1-С6алкокси(С1-С6)алкилокси или С1-С6алкокси(С1-С6)алкил; R2 означает галоген, С1-С4алкил или С1-С4алкокси; R3 и R4 независимо означают разветвленный С3-С6алкил; и R5 означает С3-С12циклоалкил, C1-С6алкил, C1-С6гидроксиалкил, С1-С6алкокси(С1-С6)алкил, С1-С6алканоилокси(С1-С6)алкил, С1-С6аминоалкил, С1-С6алкиламино(С1-С6)алкил, С1-С6диалкиламино(С1-С6)алкил, C1-С6алканоиламино(С1-С6)алкил, НО(O)С-(С1-С6)алкил, С1-С6алкил-O-(O)С-(С1-С6)алкил, H2N-С(O)-(С1-С6)алкил, С1-С6алкил-HNC(O)-(С1-С6)алкил или (С1-С6алкил)2N-С(O)-(С1-С6)алкил или их фармацевтически приемлемых солей, которые обладают ингибирующей способностью в отношении ренина, а также к основным промежуточным соединениям, полученным на стадиях синтеза конечных соединений и к способам синтеза указанных промежуточных соединений. 24 н. и 19 з.п. ф-лы.

2-БРОМТЕТРАФТОРЭТИЛХЛОРСУЛЬФАТ В КАЧЕСТВЕ ПОЛУПРОДУКТА ДЛЯ СИНТЕЗА ЭТИЛБРОМДИФТОРАЦЕТАТА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И СПОСОБ ПОЛУЧЕНИЯ ЭТИЛБРОМДИФТОРАЦЕТАТА

Изобретение относится к способам получения эфиров фторированных кислот, а именно бромдифторуксусной кислоты, в частности этилбромдифторацетата. Этилбромдифторацетат является важным интермедиатом в синтезе многих фармацевтических препаратов, а также средств защиты растений. Настоящим изобретением предлагается способ получения этилбромдифторацетата, включающий взаимодействие 2-бром-тетрафторэтилгалогенсульфата, где галоген - хлор или фтор, с этиловым спиртом в присутствии основания при охлаждении; 2-бромтетрафторэтилхлорсульфат в качестве полупродукта для получения этилбромдифторацетата; а также способ получения 2-бромтетрафторэтилхлорсульфата взаимодействием тетрафторэтилена со свежеполученным из брома и хлора хлористым бромом и хлорсульфоновой кислотой, с последующим выделением его из реакционной смеси отгонкой в вакууме. 3 н. и 5 з.п. ф-лы, 4 пр.

New cyclopropanecarboxylic acid derivatives, process for their preparation and their application in combating parasites

INTERMEDIATES IN THE PREPARATION OF CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES

CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES; PROCESS FOR PREPARING THE SAME AND THEIR USE FOR CONTROLLING PLANT AND INDOOR PESTS; COMPOSITIONS THEREOF AND NEW INTERMEDIATES PRODUCED

Аммониевая соль @ -октилтиоакриловой кислоты в качестве реагента-собирателя при флотационной очистке сточных вод

Аммониевая соль|5 -октилтиоакриловой кислоты CgH SCH CHCCOqNH4 в качестве реагента-собирателя при флотационной очистке сточных вод. (Л ...

Способ получения 2-окси-3-алкил(алкенил)-тиопропиловых эфиров альфа,бета-ненасыщенных кислот

PHARMACEUTICALLY ACCEPTABLE COMPOSITION CONTAINING AT LEAST ONE DERIVATIVE OF THE CYCLOPROPANE CARBOXYLIC ACID

L'invention concerne l'application par exemple, à la lutte contre les parasites des animaux, des compositions renfermant les composés (I') (I') où la double liaison est E ou Z, A' est un reste d'alcool et R est un alcoyl (C1-C18) substitué par un ou plusieurs groupements fonctionnels identiques ou différents ou un aryl (C6-C14) ou un hétérocycle, éventuellement substitué par un ou plusieurs groupements fonctionnels identiques ou différents.

NOUVEAUX DERIVES DE L'ACIDE CYCLOPROPANE CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION, ET LEUR APPLICATION A LA LUTTE CONTRE LES PARASITES

L'INVENTION A POUR OBJET LES COMPOSES DE FORMULE(I): (CF DESSIN DANS BOPI) DANS LAQUELLE, A REPRESENTE LE RESTE D'UN RADICAL ALCOOL, R REPRESENTE UN RADICAL ALCOYLE SUBSTITUE PAR UN OU PLUSIEURS GROUPEMENTS FONCTIONNELS, OU UN RADICAL HETEROCYCLIQUE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS GROUPEMENTS FONCTIONNELS, OU UN RADICAL ARYLE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS GROUPEMENTS FONCTIONNELS. LES COMPOSES DE FORMULE(I) PRESENTENT D'INTERESSANTES PROPRIETES PESTICIDES NOTAMMENT INSECTICIDES.

NEW DERIVATIVES OF THE CARBOXYLIC ACID CYCLOPROPANE, THEIR METHOD OF PREPARATION, AND THEIR APPLICATION TO THE FIGHT AGAINST THE PARASITES

METHOD OF PREPARING METHYL (Ｅ)-2-(3-METHOXY)ACRYLATE FROM 2-(3,3-DEMETHOXY)PROPANOATE

PHARMACEUTICALLY ACCEPTABLE COMPOSITION CONTAINING AT LEAST ONE DERIVATIVE OF THE CYCLOPROPANE CARBOXYLIC ACID

VINYL-CARBOXYLATE DERIVATIVES OF CYCLOPROPANE CARBOXYLIC ACIDESTERS AND USE AS PESTICIDES

METHOD OF PREPARING METHYL (Ｅ)-2-(3-METHOXY)ACRYLATE FROM 2-(3,3-DEMETHOXY)PROPANOATE

2-БРОМТЕТРАФТОРЭТИЛХЛОРСУЛЬФАТ В КАЧЕСТВЕ ПОЛУПРОДУКТА ДЛЯ СИНТЕЗА ЭТИЛБРОМДИФТОРАЦЕТАТА

Изобретение относится к способам получения эфиров фторированных кислот, а именно бромдифторуксусной кислоты, в частности этилбромдифторацетата. Этилбромдифторацетат является важным интермедиатом в синтезе многих фармацевтических препаратов, а также средств защиты растений. Настоящим изобретением предлагается способ получения этилбромдифторацетата, включающий взаимодействие 2-бромтетрафторэтилгалогенсульфата, где галоген - хлор или фтор, с этиловым спиртом в присутствии основания, такого как триэтиламин, при охлаждении; 2-бромтетрафторэтилхлорсульфат в качестве полупродукта для получения этилбромдифторацетата, а также способ его получения 2-бромтетрафторэтилхлорсульфата взаимодействием тетрафторэтилена со свежее полученным полученным хлористым бромом и хлорсульфоновой кислотой, с последующим вьщелением его из реакционной смеси отгонкой в вакууме.

Cyclopropane-carboxylic-acid derivatives, their preparation, their use in combating vegetal parasites, animals and locations, their compositions, and intermediates

INTERMEDIATES IN THE PREPARATION OF CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES

Catalysed hydrogenation of carboxylic acids and their anhydrides to alcohols and/or esters

Processes for Production of 2-Bromo-2,2-Difluoroethanol and 2-(Alkylcarbonyloxy)-1,1-Difluoroethanesulfonic Acid Salt

Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a substituted or unsubstituted linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 15 carbon atoms, a heteroaryloxy group having 4 to 15 carbon atoms, or a halogen atom.

VERFAHREN ZUR HERSTELLUNG NEUER DERIVATE DER ZYKLOPROPAN-KARBOXYLSAEURE

Method for preparing 5-chlorine-1-oxo-2,3-dihydroindene-2-carboxylic acid methyl ester

The invention belongs to the technical field of preparing pesticide intermediates and pharmaceutical intermediates, in particular to a method for preparing 5-chlorine-1-oxo-2, 3-dihydroindene-2-carboxylic acid methyl ester. The method is characterized in that in an inert atmosphere, 5-chlorine-1-indanone solution and dimethyl carbonate in which NaH is dissolved are mixed with each other, and then are processed by condensation reaction under the condition of certain temperature; and after the reaction, water and hydrochloric acid with certain concentration are added, the reactant is extracted, dried and filtered, filtered liquor is distilled by pressure reduction to obtain a crude product, and after the crude product is processed by chromatographic column chromatographic separation, a pure product can be obtained. The invention aims at providing the method for preparing the 5-chlorine-1-oxo-2, 3-dihydroindene-2-carboxylic acid methyl ester, which is basically free from contamination, causes ...

PROCESS FOR PREPARING DERIVATIVES OF CYCLOPROPANE CARBOXYLIC ACID

Esters I [R = (un)substituted alkyl, aryl, heterocyclic; A' = alkyl, (un)substituted benzyl, furylmethyl, cyclopentenyl, pyridylmethyl, dicarboximidomethy ! were prepd. Thus, 1.33 g I (R = CH2CF3; A' = CH(CN)C6H4OPh-3) was obtained by esterifying 1.3 g of the I(R = CH2CF3; A' = H) (II) with 1.35 g of alcohol. The ester had an LD50 against houseflies of 1.115 ng/fly. II was prepd. from tert-Bu (1R, c:s) 2,2-dimethyl-3-(2,2-dibromovinyl)cyclopropanecarboxylate by carbonylation, esterification with CF3CH2OH, hydrolysis, and hydrogenation of the triple bond. Copyright 1997 KIPO ...

PREPARATION METHOD OF SUCCINIC ACID DIESTER

Disclosed is a method for preparing succinic acid diester, in which levulinic acid or levulinate esters are used as raw materials, molecular oxygen is used as oxygen source, and succinic acid diester is produced by catalytic selective oxidation and esterification reaction. The levulinic acid or levulinate esters used as raw materials in the method can be obtained from biomass such as cellulose, starch, agricultural and forestry residues or the like. The method is a new route for preparing succinic acid diester that does not rely on fossil resourse. As the reaction condition in the process is moderate and has a high succinic acid diester selectivity, it has important application prospect.

NEW DERIVATIVE OF CYCLOPROPANECARBOXYLIC ACID

PURPOSE: To provide a new cyclopropanecarboxylic acid derivative useful as intermediate of pyrethroid compound. CONSTITUTION: The compound of formula I, for example, (1Rcis)2,2- dimethyl-3[(Z)-3-(2,2,2-trifluoroethoxy)-3-oxo-1-propenyl]cyclopropanecarboxylic acid (S)-alpha-cyano-3-phenoxybenzyl, is produced by allowing the compound of formula V (alk is 1-20C alkyl) to react with alkaline reagent and the reagent which carboxyl group can be introduced, and to esterify the obtained compound of formula VI. In formula I, R is substituted 1-18C alkyl, optionally substituted 6-14C aryl or optionally substituted heterocyclic group; Q' is H, 1-20C alkyl or A'; A' is 1-18C alkyl, optionally substituted benzyl, formula II (R1 is H or methyl; R2 is monocyclic aryl or CH2-C≡CH), formula III ((a) is H or methyl; R3 is organic aliphatic group that has 2-6C and one or more unsturated C-C), formula IV (R1' and R2' are each H, halogen, 1-6C alkyl, 6-10C aryl, etc.), etc. COPYRIGHT: (C)1992,JPO ...

CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE

Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.

METHODS FOR PREPARING ESTER OF 1,3-PROPYLENE GLYCOL AND 1,3- PROPYLENE GLYCOL

Disclosed are methods for preparing an ester of 1,3-propylene glycol and 1,3-propylene glycol, wherein vinyl ester of an organic acid is used as the raw material to obtain the ester of 1,3-propylene glycol, and the obtained ester of 1,3-propylene glycol is hydrolyzed to obtain 1,3-propylene glycol. Said method for preparing the ester of 1,3-propylene glycol includes the following step: the vinyl ester of an organic acid is hydroformylated with CO and H2. The ester of 1,3-propylene glycol may be obtained directly by said reaction through one step, or an aldehyde is obtained firstly by said hydroformylation, then the ester of 1,3-propylene glycol is obtained by reduction the aldehyde with hydrogen. It is easy to refine the present products, the cost for post-treatment of the products is decreased, and the ester of 1,3-propylene glycol may be used directly to prepare PTT fibre without hydrolyzation.

Adipolydithioglykolsaeure und ihre Salze

Aryl sulfonium salt, polymerizable composition and polymerization method of the same

An aryl sulfonium salt, whose photo-induced products are non-benzene, is represented by the formula (I): , wherein Z represents a hydrogen atom or the formula (II): , The substituted groups of R1 to R12 are independently a hydrogen atom, a C1 to C12 alkyl group or a C3 to C12 cyclic alkyl group, and each phenyl group independently has at least one of the alkyl group or the cyclic alkyl group; and X- and Y- are independently an anion. A polymerizable composition containing the aryl sulfonium salt and a polymerization method of the same are provided.

PROCESS FOR THE PRODUCTION OF VICINAL POLYCARBONYL COMPOUNDS

INSEKTIZIDE, AKARIZIDE UND NEMATIZIDE MITTEL

Cyclopropane-carboxylic-acid derivatives, their preparation, their use in combating vegetal parasites, animals and locations, their compositions, and intermediates

The application for the 2nd certificate of addition to the main patent application has the aim of illustrating the general formula I of this application by new examples, namely: - (S)-cyano(3-phenoxy-4-fluorophenyl)methyl (1R)-cis-2,2-dimethyl-3-Ä(Z)-3-oxo-3-(2,2,2-trifluoroethoxy)-1- propenylÜcyclopropanecarboxylate; - 3-propyn-2-yl 2,5-dioxoimidazolidinyl)methyl (1R)-cis-2,2-dimethyl-3Ä(Z)-3-oxo-3-hexafluoroisopropyloxy-1-propenylÜ cyclopropanecarboxylate. <>The application relates to the pesticidal compositions containing these compounds.

CYCLOPROPANE-CARBOXYLIC-ACID DERIVATIVES, THEIR PREPARATION, THEIR USE IN COMBATING VEGETAL PARASITES, ANIMALS AND LOCATIONS, THEIR COMPOSITIONS, AND INTERMEDIATES

CATALYSED HYDROGENATION OF CARBOXYLIC ACIDS AND THEIR ANHYDRIDES TO ALCOHOLS AND/OR ESTERS

VERFAHREN ZUR HERSTELLUNG VON VICINALEN POLYCARBONYLVERBINDUNGEN

New technology for producing ethyl lactate

New technology for producing ethyl lactate

The present invention relates to a new process for producing ethyl lactate. It uses lactic acid and ethyl alcohol as raw materials, and uses a mixture of three acidic compounds as catalyst, and uses absolute ethyl alcohol as dehydrolyzing agent, and makes the above-mentioned materials pass through such processes of full reflux esterification, absolute ethyl alcohol dehydration esterification, recovering ethyl alcohol, and vacuum rectification to prepare ethyl lactate. The invented technique is mature, its operation is stable, and its lactic acid yield is up to 97.2%. As compared with existent technique, said invention has the advantages of low raw material consumption, low production cost, large equipment production capacity and good product quality, etc..

PROCESSOS DE PREPARACAO DE COMPOSTOS,APLICACAO DOS DITOS COMPOSTOS,E COMPOSICOES DESTINADAS AO COMBATE DE PARASITAS

Cyclopropane-carboxylic-acid derivatives, their preparation, their use in combating vegetal parasites, animals and locations, their compositions, and intermediates

The application for the 2nd certificate of addition to the main patent application has the aim of illustrating the general formula I of this application by new examples, namely: - (S)-cyano(3-phenoxy-4-fluorophenyl)methyl (1R)-cis-2,2-dimethyl-3-Ä(Z)-3-oxo-3-(2,2,2-trifluoroethoxy)-1- propenylÜcyclopropanecarboxylate; - 3-propyn-2-yl 2,5-dioxoimidazolidinyl)methyl (1R)-cis-2,2-dimethyl-3Ä(Z)-3-oxo-3-hexafluoroisopropyloxy-1-propenylÜ cyclopropanecarboxylate. The application relates to the pesticidal compositions containing these compounds.

CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE

NOVEL DERIVATIVE OF CYCLOPROPANECARBOXYLIC ACID

Cardanol glycidyl ether derivatives

Methacrylated cardanol glycidyl ethers, diglycidyl ethers, intermediates and derivatives thereof are described herein. Compositions and polymers made with such compounds as well as methods of preparation thereof are also described. For example, compounds of Formulas: wherein n, R1, R2, R3, R4, R5, and R6 can each represent various different entities are described in the present disclosure.

Preparation method of trifluorophenylpyrimidine intermediate dimethyl 2-[3-(trifluoromethyl) phenyl] malonate

The invention relates to a preparation method of a trifluorobenzene pyrimidine intermediate dimethyl 2-[3-(trifluoromethyl) phenyl] malonate, which comprises the following steps: firstly, catalyzing condensation of m-trifluoromethyl benzyl cyanide and dimethyl carbonate by using sodium methoxide to obtain 2-cyano-2-[3-(trifluoromethyl) phenyl] methyl acetate; and carrying out alcoholysis reaction on 2-cyano-2-[3-(trifluoromethyl) phenyl] methyl acetate, dry hydrogen chloride and methanol to obtain imino ester hydrochloride, and directly adding water to carry out hydrolysis reaction to generate 2-[3-(trifluoromethyl) phenyl] dimethyl malonate. Compared with the prior art, the method has the advantages that the process of hydrolyzing m-trifluoromethyl phenylacetonitrile into m-trifluoromethyl phenylacetic acid is omitted, the reaction process is shortened, the conditions are mild, the operation is simple, and industrialization is easy to realize.

Preparation of chemical compounds

Synthetic method of 4-(2,2-dichloro cyclopropyl)phenol acetate

Processes for production of 2-bromo-2,2-difluoroethanol and 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfonic acid salt

Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a substituted or unsubstituted linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 15 carbon atoms, a heteroaryloxy group having 4 to 15 carbon atoms, or a halogen atom.

ALPHA-FLUORO-ALPHA,BETA-SULFUR-CONTAINING UNSATURATED COMPOUND

NEW MATERIAL:The compound of formula 8 [R1 is (substituted) aliphatic or aromatic group; R2 is C(=O)SR4 (R4 is same as R1) or -CF2SR4; R3 is H or same as R1]. USE: Useful as a synthetic intermediate of a fluorine-containing organic compound such as β-fluoroallyl alcohol, a heterocyclic compound, etc. PREPARATION: The compound of e.g. formula 6 can be prepared by (1) converting the compound of formula 1 prepared by conventional method to the addition product of formula 3, (2) dehydrofluorinating the addition product to the ketone of formula 4 simultaneously to the step (1), (3) reacting the ketone with a Grignard reagent, and (4) heating the resultant carbinol of formula 5 at 100W 200°C. COPYRIGHT: (C)1985,JPO&Japio ...

NEW DERIVATIVE OF CYCLOPROPANE CARBOXYLIC ACID

NEW MATERIAL: A compound expressed by formula I or formula II wherein R is (substd.) 1 to 18C alkyl, (substd.) 6 to 14C aryl or (substd.) heterocyclic group; Q is H or 1 to 20C alkyl; Q' is Q or A' (A' is 1 to 18C alkyl, (substd.) benzyl, formula III (R1 is H or methyl; R2 is monocyclic aryl or CH2-C=CH), formula IV ((a) is H or methyl; R3 is 2 to 6C org. aliphatic group having one or more carbon-carbon unsatd. bonds). etc. EXAMPLE: (1R,cis)2,2-dimethyl-3-[(2)3-(2,2,2-trifluoroethoxy)-3-oxo-1- propenyl]cyclopropane carboxylic acid (S)a-cyano-3-phenoxybenzyl. USE: Insecticide. Useful to exterminate parasites of plants, animals and houses. PREPARATION: For example, an acid expressed by formula V is allowed to react with an alcohol of A'-OH preferably in the presence of dicyclohexylcarbodiimide to obtain a compd. of formula II with Q' being A'. COPYRIGHT: (C)1989,JPO ...

NOVEL DERIVATIVES OF CYCLOPROPANECARBOXYLIC ACID, MANUFACTURE, USE FOR REPULSION OF PLANT, ANIMAL AND HOUSE INSECT, COMPOSITION CONTAINING THEM AND NOVEL INTERMEDIATE

PREPARATION OF TRICYCLIC CARBOXYLATE

PURPOSE: To obtain the titled compound in high yield without causing any difficulty in stirring of the system during the reaction, by reacting a carboxylic acid with a dialkyl sulfate while being brought into contact with an alkali aqueous solution without using a solvent. CONSTITUTION: 1mol tricyclo[5,1,1,02,6]decanr-2-carboxylic acid shown by the formulaIis reacted with 1.0W2.0mol dialkyl sulfate having 1W3C alkyl group while being brought into contact with an aqueous solution of a hydroxide or a carbonate of an alkali metal, to give the desired compound shown by the formula II (R is 1W3C alkyl). In the reaction, preferably the alkali aqueous solution is added dropwise to the mixture of the carboxylic acid and the dialkyl sulfate, and, especially the solution is added dividedly several times, the procedure wherein the solution is partly added, the reaction is carried out, the water layer is taken out is repeated to raise the yield of the carboxylate. After the reaction is over, the reaction ...