21-05-2020 дата публикации
Номер: US20200157049A1
Принадлежит:
The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): 130-. (canceled)32. The compound of claim 31 , wherein Rand Rcombine to form a carbonyl group.33. The compound of claim 31 , wherein Rand Y combine to form a ring with Q claim 31 , the ring including between 3 and 12 ring atoms.34. The compound of claim 33 , wherein the ring includes between 4 and 7 ring atoms.37. The compound of claim 36 , wherein the compound comprises one of a (+) enantiomer of the compound or a (−) enantiomer of the compound in an enantiomeric excess of greater than 50%.39. The compound of claim 38 , wherein the compound comprises one of a (+) enantiomer of the compound or a (−) enantiomer of the compound in an enantiomeric excess of greater than 50%.40. The compound of claim 38 , wherein:{'sup': '1', 'Ris selected from halogen, alkyl, optionally substituted aralkyl, optionally substituted alkoxycarbonylalkyl, optionally substituted cyanoalkyl, and optionally substituted hydroxyalkyl; and'}{'sup': 6', '9', '10, 'R, R, and Rare independently selected at each occurrence from aralkyloxy, aralkoxycarbonyl, heteroaryloxy, acyl, arylcarbonyl, aralkylcarbonyl, arylsulfonyl, alkoxycarbonyl, and aryloxycarbonyl.'}41. The compound of claim 40 , wherein:{'sup': '6', 'X is —NR—;'}{'sup': 7', '7, 'Z is selected from —C(O)— and —CRR—;'}{'sup': 7', '7, 'A at each occurrence is —CRR—;'}{'sup': 10', '11', '11, 'W is selected from —NR— and —CRR—; and'}n is 0-2.42. The compound of claim 41 , wherein n is 1.43. The compound of claim 38 , wherein:X is —O—;{'sup': 7', '7, 'Z is selected from —C(O)— and —CRR—;'}{'sup': 7', '7, 'A at each occurrence is —CRR—;'}{'sup': 10', '11', '11, 'W is selected from —NR—, and —CRR—; and'}n is 0-2.45. The method of claim 44 , wherein:{'sup': '6', 'X is —NR—;'}{'sup': 7', '7, 'A at each occurrence is —CRR—;'}{'sup': 10', '11', '11, 'W is selected from — ...
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