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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 19246. Отображено 100.

12-01-2012 дата публикации

Pest controlling composition

Номер: US20120010251A1

Автор: Nishimura Shinya, Norihisa Sakamoto

Принадлежит: Sumitomo Chemical Co Ltd

The present invention provides a pest controlling composition comprising, as active ingredients, an amide compound of the formula (I) and a pyrethroid compound; and so on.

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Номер записи: 1

26-01-2012 дата публикации

Method for producing 2,2 difluoroethylamine derivatives by imine hydrogenation

Номер: US20120022264A1

Автор: Norbert Lui, Stefan Antons

Принадлежит: Bayer CropScience AG

Process for preparing 2,2-difluoroethylamine derivatives, wherein compounds of the general formula (IV) are hydrogenated to the corresponding 2,2-difluoroethylamine derivatives of the general formula (III), where the A, R 1 and R 2 radicals are each as defined in the description:

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Номер записи: 2

09-02-2012 дата публикации

Pest control composition

Номер: US20120035218A1

Автор: Kaori Ikari

Принадлежит: Sumitomo Chemical Co Ltd

[Object] A composition having an excellent control activity on pests is provided. [Means of Achievement] A pest control composition comprising (i) a hydrazide compound shown by the following formula (1) [wherein G, M, Q 1 , Q 2 , Q 3 , Q 4 , R 2 , R 4 , R 5 , R 6 , and m have the meanings listed in the specification, and (ii) pyriproxyfen. A pest control method comprising a step of applying effective amounts of (i) a hydrazide compound shown by the following formula (1) and (ii) pyriproxyfen to pests or pest habitats. [Selected Drawing] None

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Номер записи: 3

15-03-2012 дата публикации

Insect repellent composition

Номер: US20120065229A1

Автор: Marc Esculier

Принадлежит: Dakem SA

The present invention relates to an insect repellent composition containing the following active insect-repellent material in a physiologically acceptable medium: at least 1-methylpropyl(2-(2-hydroxyethyl)piperidine-1-carboxylate, said active material being used with at least one copolymer of vinylpyrrolidone and of a linear alkyl, having at least 16 carbon atoms, as a film-forming agent. The invention also relates to an insect-repelling method using said composition.

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Номер записи: 4

12-04-2012 дата публикации

Combined use of two insecticides

Номер: US20120087987A1

Автор: Darren M. Jahnke, S. John Barcay, Victor F. Man, Yvonne M. Killeen

Принадлежит: ECOLAB USA INC

The present disclosure relates to the combined use of two pesticides. A first pesticide composition provides an initial contact kill, and may form a barrier when applied to greasy surfaces. A second pesticide composition provides residual pesticidal activity on the surface. Methods of making and using the pesticide compositions are also provided.

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Номер записи: 5

17-05-2012 дата публикации

Pesticide compositions including polymeric adjuvants

Номер: US20120122687A1

Автор: John Larry Sanders

Принадлежит: SPECIALTY FERTILIZER PRODUCTS LLC

Pesticidal compositions of improved effectiveness are provided, including a pesticide (e.g., an insecticide or herbicide) together with a copolymer adjuvant or additive selected from the group consisting of acid or salt copolymers containing individual quantities of maleic and itaconic moieties. The compositions of the invention provide multiple-fold increases in effectiveness, as compared with an equal amount of the pesticide in the absence of the copolymer.

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Номер записи: 6

21-06-2012 дата публикации

Microcapsule and production method thereof

Номер: US20120156303A1

Автор: Mayuko Ozawa, Naoki Tsuda

Принадлежит: Sumitomo Chemical Co Ltd

A microcapsule in which a liquid droplet is coated with a resin, wherein in the droplet, a pesticidally active solid ingredient is suspended in a compound of formula (I), wherein R represents a C1-C5 alkyl group, is useful as a formulation of a pesticidally active solid ingredient.

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Номер записи: 7

01-11-2012 дата публикации

Insecticidal Compositions Suitable for Use in Preparation of Insecticidal Granular Fertilizer and Insecticidal Formulations

Номер: US20120277103A1

Автор: Coby L. Crane, David R. Kilanowski, Edward Kikta, Kim Watson, Larry G. Faehl, Robert Radabaugh

Принадлежит: FMC Corp, Scotts Co LLC

Insecticidal compositions suitable for use in preparation of insecticidal granular fertilizer and insecticidal formulations comprising a pyrethroid and a glycol present in a concentration of from 40.0% by weight to 99.0% by weight based upon the total weight of all components in the composition is disclosed.

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Номер записи: 8

29-11-2012 дата публикации

Herbicidal mixtures

Номер: US20120302441A1

Автор: Adam F. Burnhams, Andress Landes, Bernd Sievernich, Cyrill Zagar, Herve R. Vantieghem, Peter Dombo

Принадлежит: BASF SE

A synergistic herbicidal mixture comprising A) picolinafen; or one of its environmentally compatible salts; and B) a synergistically effective amount of at least a sulfonylurea of formula II wherein the variables A, B, X and R 1 to R 3 have the meanings given in the specification; and, if desired, C) at least a safener. Compositions comprising these mixtures, processes for the preparation of these compositions and their use for controlling undesired plants.

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Номер записи: 9

03-01-2013 дата публикации

3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinates and their use as herbicides

Номер: US20130005574A1

Автор: Carla N. Yerkes, Christian T. Lowe, James M. Renga, Jeffrey B. Epp, Jeremy Kister, Joseph D. Eckelbarger, Joshua Roth, Katherine A. Guenthenspberger, Lindsey G. FISCHER, Natalie C. GIAMPIETRO, Paul R. Schmitzer, Thomas L. Siddall

Принадлежит: Eckelbarger Joseph D, Epp Jeffrey B, Fischer Lindsey G, Giampietro Natalie C, Guenthenspberger Katherine A, Jeremy Kister, Joshua Roth, Lowe Christian T, Renga James M, Schmitzer Paul R, Siddall Thomas L, YERKES CARLA N

3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinic acids having a halogen, alkyl or mono-, di- tri- and tetra-substituted aryl substituents in the 6-position, and their acid derivatives, are herbicides demonstrating a broad spectrum of weed control.

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Номер записи: 10

17-01-2013 дата публикации

Deuterated pirfenidone

Номер: US20130018193A1

Автор: Julie F. Liu, Yong Dong

Принадлежит: Concert Pharmaceuticals Inc

This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor.

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Номер записи: 11

21-03-2013 дата публикации

PESTICIDAL COMPOSITIONS

Номер: US20130072382A1

Автор: Bryan Kristy, Buysse Ann M., Deamicis Carl, Eckelbarger Joseph D., Garizi Negar, Hunter Ricky, Johnson Peter Lee, Johnson Timothy C., JR. Ronald, McLeod CaSandra Lee, Niyaz Noormohamed M., Parker Marshall H., Pernich Dan, Ross, Trullinger Tony K., Yap Maurice C. H., Zhang Yu, Zhu Yuanming

Принадлежит: DOW AGROSCIENCES LLC

This document discloses molecules having the following formula (“Formula I”): 3. A molecule according to wherein(a) X is CR8;(b) R1 is H;(c) R2 is H;(d) R3 is H;{'sub': 1', '3, '(e) R4 is Cor CH;'}{'sub': 1', '6, '(f) R5 is H or unsubstituted C-Calkyl;'}(g) R6 is O;{'sub': 1', '6', 'n', '1', '6', '1', '6', 'n', '1', '6', '1', '6', '1', '6, '(h) R7 is (unsubstituted C-Calkyl)S(O)(unsubstituted C-Calkyl), (unsubstituted C-Calkyl)S(O)(unsubstituted C-Calkenyl), O(unsubstituted C-Calkyl), (C-Calkyl);'}(i) R8 is H or F; and(k) n is 0, 1, or 2.4. A molecule according to or in the form of a pesticidally acceptable acid addition salt claim 2 , salt derivative claim 2 , or solvate.5. A molecule according to or having at least one H.6. A molecule according to or having at least one C.7. A molecule according to or that is a resolved stereoisomer.8. A composition comprising a molecule according to or and at least one member of the Insecticide Group claim 2 , Acaricide Group claim 2 , Nematicide Group claim 2 , Fungicide Group claim 2 , or Herbicide Group.9. A composition comprising a molecule according to or and at least one biopesticide.10. A composition comprising a molecule according to or and at least one of the following compounds:(a) 3-(4-chloro-2,6-dimethylphenyl)-4-hydroxy-8-oxa-1-azaspiro[4,5]dec-3-en-2-one;(b) 3-(4′-chloro-2,4-dimethyl[1,1′-biphenyl]-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4,5]dec-3-en-2-one;(c) 4-[[(6-chloro-3-pyridinyl)methyl]methylamino]-2(5H)-furanone;(d) 4-[[(6-chloro-3-pyridinyl)methyl]cyclopropylamino]-2(5H)-furanone;(e) 3-chloro-N2-[(1S)-1-methyl-2-(methylsulfonyl)ethyl]-N1-[2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarboxamide;(f) 2-cyano-N-ethyl-4-fluoro-3-methoxy-benenesulfonamide;(g) 2-cyano-N-ethyl-3-methoxy-benzene sulfonamide;(h) 2-cyano-3-difluoromethoxy-N-ethyl-4-fluoro-benzene sulfonamide;(i) 2-cyano-3-fluoromethoxy-N-ethyl-benzenesulfonamide;(j) 2-cyano-6-fluoro-3-methoxy-N,N-dimethyl-benzenesulfonamide ...

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Номер записи: 12

21-03-2013 дата публикации

Pesticidal Mixtures

Номер: US20130072384A1

Автор: Gewehr Markus, Haden Egon, LANGEWALD Juergen, Pohlman Matthias

Принадлежит: BASF SE

The present invention relates to a mixture comprising [(3S,4R,4aR,6S,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12H-benzo[f]pyrano[4,3-b]chromen-4-yl]methyl cyclopropanecarboxylate and a fungicidal compound II in synergistic effective amounts, to the use of this mixture for controlling pests and for improving the plant health and to plant propagation material comprising this mixture. 125-. (canceled)27. The mixture according to claim 26 , wherein the fungicidal compound II is selected from the group consisting of azoxystrobin claim 26 , coumethoxystrobin claim 26 , coumoxystrobin claim 26 , dimoxystrobin claim 26 , enestroburin claim 26 , fluoxastrobin claim 26 , kresoxim-methyl claim 26 , metominostrobin claim 26 , orysastrobin claim 26 , picoxystrobin claim 26 , pyraclostrobin claim 26 , pyrametostrobin claim 26 , pyraoxystrobin claim 26 , pyribencarb and trifloxystrobin.28. The mixture according to claim 27 , wherein the fungicidal compound II is selected from the group consisting of azoxystrobin claim 27 , dimoxystrobin claim 27 , enestroburin claim 27 , fluoxastrobin claim 27 , kresoxim-methyl claim 27 , metominostrobin claim 27 , orysastrobin claim 27 , picoxystrobin claim 27 , pyraclostrobin claim 27 , pyribencarb and trifloxystrobin.29. The mixture according to claim 28 , wherein the fungicidal compound II is selected from the group consisting of dimoxystrobin claim 28 , enestroburin claim 28 , metominostrobin and pyraclostrobin.30. The mixture according to claim 26 , wherein the fungicidal compound II is selected from the group consisting of bixafen claim 26 , boscalid claim 26 , fluxapyroxad claim 26 , isopyrazam claim 26 , penflufen claim 26 , penthiopyrad claim 26 , sedaxane claim 26 , metalaxyl and ofurace.31. The mixture according to claim 30 , wherein the fungicidal compound II is selected from the group consisting of bixafen claim 30 , fluxapyroxad claim ...

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Номер записи: 13

28-03-2013 дата публикации

ESTER COMPOUND AND USE THEREOF

Номер: US20130079378A1

Автор: Matsuo Noritada

Принадлежит: Sumitomo Chemical Company, Limited

An ester compound represented by formula (1): wherein Rrepresents hydrogen or methyl, Rrepresents hydrogen or C1-C4 alkyl, and Rrepresents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent. 2. The ester compound according to claim 1 , wherein a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration in formula (1).3. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration in formula (1).4. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration claim 1 , and a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration in formula (1).5. The ester compound according to claim 1 , wherein a relative configuration of the substituent of the 1′-position existing on the substituent at the 3-position of the cyclopropane ring is Z-configuration in formula (1).6. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration and a relative configuration of the substituent of the 1′-position existing on the substituent at the 3-position of the cyclopropane ring is Z-configuration in formula (1).7. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration claim 1 , a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration claim 1 , and a relative configuration of the substituent of the 1′-position existing on the substituent at ...

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Номер записи: 14

04-04-2013 дата публикации

PESTICIDAL MIXTURES CONTAINING ISOXAZOLINE DERIVATIVES AND INSECTICIDE OR NEMATOICIDAL BIOLOGICAL AGENT

Номер: US20130085064A1

Автор: ANGST Max, Cassayre Jerome Yves, DUTTON Ana Cristina, HOEGGER Patrik

Принадлежит: SYNGENTA CROP PROTECTION LLC

The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) wherein A, A, R, R, R, Rand Rare as defined in claim and one of Yand Yis S, SO or SOand the other is CHand component B is an insecticide or nematicidal biological agent as defined in claim . The present invention also relates to methods of using said mixtures for the control of pests. 2. A pesticidal mixture according to claim 1 , wherein in the compound of formula I L is a direct bond or methylene; one of Yand Yis S and the other is CH; Aand Aare C—H; Ris hydrogen or methyl; Ris trifluoromethyl; Ris 3 claim 1 ,5-dichloro-phenyl; Ris methyl; and Ris hydrogen.3. A pesticidal mixture according to claim 1 , wherein in the compound of formula I L is a direct bond or methylene; one of Yand Yis SO and the other is CH; Aand Aare C—H; Ris hydrogen or methyl; Ris trifluoromethyl; Ris 3 claim 1 ,5-dichloro-phenyl; Ris methyl; and Ris hydrogen.4. A pesticidal mixture according to claim 3 , wherein the molar proportion of the cis SO compounds of formula I compared to the total amount of cis SO and trans SO compounds of formula I is greater than 50%.5. A pesticidal mixture according to claim 1 , wherein in the compound of formula I L is a direct bond or methylene; one of Yand Yis SOand the other is CH; Aand Aare C—H; Ris hydrogen or methyl; Ris trifluoromethyl; Ris 3 claim 1 ,5-dichloro-phenyl; Ris methyl; and Ris hydrogen.6. A pesticidal mixture according to claim 1 , wherein when L is a direct bond Yis CHand Yis S claim 1 , SO or SO claim 1 , and wherein when L is methylene Yis S claim 1 , SO or SOand Yis CH.8. A pesticidal mixture according to claim 1 , wherein component B is a compound selected froma) a pyrethroid selected from the group consisting of permethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin, fenpropathrin, cyfluthrin, tefluthrin, ethofenprox, ...

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Номер записи: 15

11-04-2013 дата публикации

PET RADIOPHARMACEUTICALS FOR DIFFERENTIAL DIAGNOSIS BETWEEN BILATERAL AND UNILATERAL CONDITIONS OF PRIMARY HYPERALDOSTERONISM

Номер: US20130089502A1

Автор: Allolio Bruno, Hahner Stefanie, Hartmann Rolf, Schirbel Andreas, Zimmer Christina

Принадлежит:

A functional PET imaging method is disclosed for differentiation between bilateral hyperplasia and unilateral adenoma comprising (1) introducing a radioactively labelled CYP11 B2 (aldosterone synthase) inhibitor which binds selectively to CYP11 B2 (aldosterone synthase) relative to CYP11 B1 (11β-hydroxylase) into a mammal with adrenal glands and (2) conducting positron emission tomography (PET) in the region of the adrenal glands to obtain a functional PET image of the adrenal glands. Also disclosed are radioactive tracer compounds suitable for use in this method, precursors for making the same, and a process for making the radioactive tracer compounds capable of being conducted as a rapid one-pot reaction. 1. A method for making a functional image of adrenal glands comprising (1) introducing a radioactively labelled CYP11B2 (aldosterone synthase) inhibitor which binds selectively to CYP11B2 relative to CYP11B1 (11β-hydroxylase) into a mammal with adrenal glands and (2) conducting positron emission tomography (PET) in the region of the adrenal glands to obtain a functional image of the adrenal glands.2. The method according to claim 1 , wherein the radioactively labelled CYP11B2 inhibitor comprises F.7. The compound of claim 4 , wherein Rrepresents CHCHX claim 4 , Ris H and Rand Rform claim 4 , together with the pyridine ring claim 4 , an isochinoline ring system.12. A process for making a radioactive tracer comprising reacting a compound of formula (I) according to claim 4 , wherein X represents Br claim 4 , I claim 4 , tosylate or mesylate claim 4 , with F ions to obtain a radioactive tracer compound of formula (I) in which X represents F.13. The process of claim 12 , wherein the process is conducted in the presence of a cyclic crown ether compound claim 12 , a potassium salt claim 12 , and an anhydrous polar aprotic organic solvent.14. The process of claim 12 , wherein the process is conducted at a temperature in the range from 70° C. to 100° C. for a time period ...

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Номер записи: 16

11-04-2013 дата публикации

ESTER COMPOUND AND USE THEREOF

Номер: US20130090363A1

Автор: Matsuo Noritada

Принадлежит: Sumitomo Chemical Company, Limited

An ester compound represented by formula (1): wherein Rrepresents hydrogen or methyl, Rrepresents hydrogen or C1-C4 alkyl, and Rrepresents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent. 2. The ester compound according to claim 1 , wherein a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration in formula (1).3. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration in formula (1).4. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration claim 1 , and a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration in formula (1).5. The ester compound according to claim 1 , wherein a relative configuration of the substituent of the 1′-position existing on the substituent at the 3-position of the cyclopropane ring is Z-configuration in formula (1).6. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration and a relative configuration of the substituent of the 1′-position existing on the substituent at the 3-position of the cyclopropane ring is Z-configuration in formula (1).7. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration claim 1 , a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration claim 1 , and a relative configuration of the substituent of the 1′-position existing on the substituent at ...

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Номер записи: 17

11-04-2013 дата публикации

PYRETHRINOID-TYPE ESTERS AS PESTICIDES

Номер: US20130090381A1

Автор: Matsuo Noritada

Принадлежит: Sumitomo Chemical Company, Limited

An ester compound represented by formula (1): wherein Rrepresents Rrepresents 2-propenyl or 2-propynyl; Rrepresents hydrogen or methyl, Rrepresents hydrogen or C1-C4 alkyl, and Rrepresents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent. 2. The ester compound according to claim 1 , wherein a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration in formula (1).3. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration in formula (1).4. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration claim 1 , and a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration in formula (1).5. The ester compound according to claim 1 , wherein a relative configuration of the substituent of the 1′-position existing on the substituent at the 3-position of the cyclopropane ring is Z-configuration in formula (1).6. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration and a relative configuration of the substituent of the 1′-position existing on the substituent at the 3-position of the cyclopropane ring is Z-configuration in formula (1).7. The ester compound according to claim 1 , wherein an absolute configuration of the 1-position of the cyclopropane ring is an R configuration claim 1 , a relative configuration of the substituent at the 1-position of the cyclopropane ring and the substituent at the 3-position of the cyclopropane ring is a trans configuration claim 1 , and a relative configuration of the substituent of ...

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Номер записи: 18

18-04-2013 дата публикации

ANTIMICROBIAL COMBINATIONS OF PYRION COMPOUNDS WITH POLYETHYLENEIMINES

Номер: US20130095058A1

Автор: Bylemans Dany Leopold Jozefien, De Bolle Miguel F.C.

Принадлежит: Janssen Pharmaceutica NV

The present invention relates to combinations of the pyrion compounds sodium pyrithione and 1-hydroxy-2-pyridinone, and polyethyleneimines (PEI) which provide an improved biocidal effect. More particularly, the present invention relates to compositions comprising a combination of a pyrion compound selected from sodium pyrithione and 1-hydroxy-2-pyridinone together with polyethyleneimines; in respective proportions to provide a synergistic biocidal effect. Compositions comprising these combinations are useful for the protection of any living or non-living material, such as crops, plants, fruits, seeds, objects made of wood, thatch or the like, engineering material, biodegradable material and textiles against deterioration due to the action of microorganisms such as bacteria, fungi, yeasts, algae, viruses, and the like. 1. A composition comprising a combination of a component (I) and a component (II) in respective proportions to provide a synergistic biocidal effect , whereby component (I) is a pyrion compound selected from sodium pyrithione (I-a) and 1-hydroxy-2-pyridinone (I-b) , andcomponent (II) are polyethyleneimines.2. The composition as claimed in wherein component (II) are polyethylene-imines with an average molecular weight between 1300 and 750000.3. The composition as claimed in wherein component (II) are polyethyleneimines with an average molecular weight of approximately 1300.4. The composition as claimed in wherein component (II) are polyethyleneimines with an average molecular weight of approximately 70000.5. The composition as claimed in wherein component (II) are polyethyleneimines with an average molecular weight of approximately 750000.6. The composition as claimed in wherein the ratio by weight of component (I) to component (II) ranges from 10:1 to 1:10.7. The composition as claimed in wherein the ratio by weight of component (I) to component (II) ranges from 4:1 to 1:4.8. The composition as claimed in wherein the ratio by weight of component (I) to ...

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Номер записи: 19

18-04-2013 дата публикации

USE OF A 1-N-(HALO-3-PYRIDYLMETHYL)-N-METHYLAMINO-1-ALKYLAMINO-2-NITROETHYLENE DERIVATIVE FOR PREPARING A TOPICAL VETERINARY PHARMACEUTICAL COMPOSITION FOR COMBATING EXTERNAL PARASITES

Номер: US20130096164A1

Автор: Derrieu Guy, Marc Jean Pascal

Принадлежит: VIRBAC

The present invention relates to the use, as active ingredient, of a 1-N-(halo-3-pyridylmethyl)-N-methylamino-1-alkylamino-2-nitroethylene derivative for preparing a veterinary pharmaceutical composition for topical application in the treatment of external parasites, in particular fleas, in domestic animals, in particular in dogs and cats, intended to be applied at least every 2 weeks. 2. The method as claimed in claim 1 , wherein said composition is a collar.3. The method as claimed in claim 1 , wherein said composition is a liquid composition comprising at least one pharmaceutically acceptable liquid carrier.46. The method as claimed in claim 1 , wherein the compound(s) of formula (I) is (are) chosen from the compounds in which the halogen atom denoted Hal is located in position of the pyridyl ring and denotes a chlorine atom.5. The method as claimed in claim 1 , wherein the compound(s) of formula (I) is (are) chosen from those in which Rrepresents a hydrogen atom claim 1 , a C-Calkyl radical or a C-Ccycloalkyl radical.6. The method as claimed in claim 1 , wherein the compound(s) of formula (I) is (are) chosen from those in which Rrepresents a C-Calkyl radical or a cyclopropyl radical.7. The method as claimed in claim 1 , wherein the compound(s) of formula (I) is (are) chosen from those in which Rrepresents a hydrogen atom.8. The method as claimed in claim 1 , wherein the pharmaceutical composition comprises claim 1 , as compound of formula (I) claim 1 , (E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N′-methyl-2-nitrovinylidenediamine (nitenpyram).9. The method as claimed in claim 1 , wherein claim 1 , within the pharmaceutical composition claim 1 , the compound(s) of formula (I) represent(s) from 5% to 20% by weight relative to the total weight of the composition.10. The method as claimed in claim 1 , wherein the compound(s) of formula (I) is (are) administered to the animal in a unit dose of between 0.1 and 200 mg/kg of body weight.11. The method as claimed in claim 3 ...

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Номер записи: 20

18-04-2013 дата публикации

Process for Preparing 4-hydroxypyridines

Номер: US20130096312A1

Автор: Grammenos Wassilios, Jabs Thorsten, Keil Michael, Lohmann Jan Klaas, MAYWALD Volker, MENGES Frederik, Mueller Bernd, Rack Michael, Vogelbacher Uwe Josef, Vrettou-Schultes Marianna

Принадлежит: BASF SE

The present invention relates to a process for preparing 4-hydroxypyridines of formula I 114-. (canceled)16. The process as claimed in claim 15 , wherein the base is selected from alkali metal methylates.17. The process as claimed in claim 16 , wherein the base is sodium methylate.18. The process as claimed in claim 15 , wherein the base is dissolved in a monohydric C-C-alcohol.19. The process as claimed in claim 18 , wherein the monohydric C-C-alcohol is methanol.20. The process as claimed in claim 15 , wherein in step a) claim 15 , b) and c) are carried out without isolating any intermediate compound.21. The process as claimed in claim 15 , wherein the acid is selected from mineral acids.22. The process as claimed in claim 15 , wherein the ammonia source is selected from the group consisting of aqueous ammonia solution claim 15 , ammonium halides claim 15 , ammonium carboxylates and ammonium sulfate.23. The process as claimed in claim 15 , wherein Ris hydrogen claim 15 , C-C-alkyl or C-C-haloalkyl.24. The process as claimed in claim 23 , wherein Ris C-C-perhaloalkyl.25. The process as claimed in claim 15 , wherein R claim 15 , R claim 15 , Rare hydrogen claim 15 , C-C-alkyl or C-C-haloalkyl.26. The process as claimed in claim 25 , wherein R claim 25 , R claim 25 , Rare hydrogen.28. The process of claim 27 , wherein the chlorinating agent is thionyl chloride or phosphoryl chloride. The present invention relates to a process for preparing 4-hydroxypyridines.Synthesis of substituted pyridines has been the subject of intensive investigations on account of their great versatility and their uses as components of active substances, especially of medicinal drugs and plant protection agents.The reaction of an acetylacetone enol ether with ethyl perfluoroalkanoates in the presence of the strong base potassium tert-butoxide, followed by acid catalyzed cyclization to yield substituted pyranones has been disclosed by Tyvorskii et al. (Tetrahedron 54 (1998), 2819-2826). The ...

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Номер записи: 21

25-04-2013 дата публикации

Insecticidal compositions and methods of using the same

Номер: US20130101687A1

Автор: Andrea Rohrbacher, Darryl Ramoutar, Frances Nita Krenick, Joanna Maria Szymczyk, Marie Elizabeth Saunders, Michael Dean Willis

Принадлежит: Clarke Mosquito Control Products Inc

Insecticidal compositions have at least one active agent and at least one insecticide. The active agent can include perilla oil, a component found in perilla oil, or a perillaldehyde or carvone analog. The insecticide can include a pyrethrum, pyrethrin, pyrethroid, neonicotinoid, chlofenapyr, ethiprole, sulfoxoflor, carbamate, organophosphate, or organochlorine. Methods for controlling insects include contacting an insect with an effective amount of a composition described in this specification. Modified plants that produce an active agent can be contacted with an insecticide.

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Номер записи: 22

25-04-2013 дата публикации

METHODS AND COMPOSITIONS FOR CONTROLLING ALGAE

Номер: US20130102638A1

Автор: Cockreham Steve D., Netherland Michael D.

Принадлежит:

Described are preferred methods and compositions for controlling algae which involve the use of bleaching pyridinecarboxamide compounds. 1. A method for control of algae in a body of water , comprising:providing in the body of water an effective algicidal concentration of a bleaching pyridinecarboxamide compound.2. The method of claim 1 , comprising maintaining in said body of water a concentration of the compound of about 1 ppb to about 80 ppb.3. The method of claim 1 , wherein said providing includes applying to said body of water an aqueous liquid formulation containing the compound.5. The method of claim 4 , wherein the compound is picolinafen.8. A method of claim 7 , wherein the compound is diflufenican.9. An algicidal concentrate composition for addition to a body of water for algae control claim 7 , comprising:a liquid carrier suitable for introduction into an aquatic environment; anda bleaching pyridinecarboxamide compound at a level constituting about 5% to about 90% of said concentrate composition.11. The composition of claim 10 , wherein said compound is picolinafen.14. The composition of claim 13 , wherein the compound is diflufenican15. A product claim 13 , comprising: a container; a composition in said container claim 13 , the composition including a bleaching pyridinecarboxamide compound; said container bearing visible indicia regarding algicidal use of the composition.17. The product of claim 16 , wherein said compound is picolinafen.20. The product of claim 19 , wherein the compound is diflufenican. The present invention relates generally to the control of algae in bodies of water such as lakes, ponds and other aqueous systems. In one particular embodiment, the present invention relates to the control of-such algae using bleaching pyridinecarboxamide compounds.As further background, undesirable growth of algal species is a continuing challenge in water bodies such as lakes, ponds and reservoirs. To date, the primary agent used to control such algal ...

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Номер записи: 23

25-04-2013 дата публикации

SYNERGISTIC PESTICIDAL MIXTURES

Номер: US20130102642A1

Автор: Babcock Jonathan M., Farrow Marc, Huang Jim X., Meade Thomas

Принадлежит: DOW AGROSCIENCES LLC

Synergistic pesticidal mixtures are provided. 1. A synergistic composition comprising(b) spirotetramat.and This applications claims priority from U.S. Provisional application 60/927,119 filed on May 1, 2007, the entire disclosure of which is hereby incorporated by reference. This application also claim priority from U.S. non-provisional application Ser. No. 12/150,801 filed May 1, 2008, the entire disclosure of which is hereby incorporated by reference. This application also claim priority from U.S. non-provisional application Ser. No. 13/096,218 filed 28 Apr. 2011, the entire disclosure of which is hereby incorporated by reference.The invention disclosed in this document is related to field of pesticides and their use in controlling pests.Pests cause millions of human deaths around the world each year. Furthermore, there are more than ten thousand species of pests that cause losses in agriculture. These agricultural losses amount to billions of U.S. dollars each year. Termites cause damage to various structures such as homes. These termite damage losses amount to billions of U.S. dollars each year. As final note, many stored food pests eat and adulterate stored food. These stored food losses amount to billions of U.S. dollars each year, but more importantly, deprive people of needed food.There is an acute need for new pesticides. Insects are developing resistance to pesticides in current use. Hundreds of insect species are resistant to one or more pesticides. The development of resistance to some of the older pesticides, such as DDT, the carbamates, and the organophosphates, is well known. But resistance has even developed to some of the newer pesticides.Therefore, a need exists for new pesticides and particularly for pesticides that have new modes of action.The examples given for the substituents are (except for halo) non-exhaustive and must not be construed as limiting the invention disclosed in this document.“alkoxy” means an alkyl further consisting of a carbon ...

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Номер записи: 24

02-05-2013 дата публикации

NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS

Номер: US20130109652A1

Автор: CID-NUNEZ Jose Maria, DUVEY Guillaume Albert Jacques, FINN Terry Patrick, IMOGAI Hassan Julian, NHEM Vanthea

Принадлежит:

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) 3. The compound of claim 2 , wherein Mis a phenyl group having at least one fluoro or chloro group.4. The compound of claim 2 , wherein Mis a phenyl group having one fluoro group and one chloro group.6. The compound of claim 2 , wherein Mis a phenyl group substituted with at least one (C-C)alkyloxy.7. The compound of claim 2 , wherein Mis a phenyl group substituted with a methoxy group.8. The compound of claim 2 , wherein Mis a phenyl group substituted with at least one tetrazolyl-(C-C)alkyloxy.10. A compound according to claim 1 , or a pharmaceutically acceptable acid or base addition salt thereof claim 1 , a stereochemically isomeric form thereof and an N-oxide form thereof claim 1 , wherein said compound is:1-(2,4-difluorobenzyl)-5-(benzofuran-2-yl)pyridin-2(1H)-one;1-benzyl-5-(4-fluorophenyl)pyridin-2(1H)-one;1-(2,4-difluorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;1-(3-chlorobenzyl)-5-(4-fluorophenyl)pyridin-2(1H)-one;1-benzyl-5-(4-methoxyphenyl)pyridin-2(1H)-one;1-(3-(trifluoromethyl)benzyl)-5-phenylpyridin-2(1H)-one;1-(4-methylbenzyl)-5-phenylpyridin-2(1H)-one;1-(2,4-difluorobenzyl)-5-(thiophen-2-yl)pyridin-2(1H)-one;1-benzyl-5-(4-chlorophenyl)pyridin-2(1H)-one;1-(3-(trifluoromethyl)benzyl)-5-(4-chlorophenyl)pyridin-2(1H)-one;1-(2,4-difluorobenzyl)-5-(4-chlorophenyl)pyridin-2(1H)-one;1-(2,4-dichlorobenzyl)-5-(4-methoxyphenyl)pyrimidin-2(1H)-one;1-(3-chlorobenzyl)-5-phenylpyridin-2(1H)-one;1-(3-chlorobenzyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one;1-Benzyl-5-phenylpyridin-2(1H)-one;1-(2,4-difluorobenzyl)-5-phenylpyridin-2(1H)-one;1-Benzyl-5-(3-methoxyphenyl)pyridin-2(1H)-one;1-Benzyl-5-(3-chlorophenyl)pyridin-2(1H)-one;1-Benzyl-5-(4-cyanophenyl)pyridin-2(1H)-one;1-Benzyl-5-(3-nitrophenyl)pyridin-2(1H)-one;1-Benzyl-5-(2-fluorophenyl)pyridin-2(1H)-one;1-Benzyl-5-(3,4-dimethoxyphenyl)pyridin-2(1H)-one;1-Benzyl-5-(naphthalen-2-yl)pyridin-2(1H)-one;1 ...

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Номер записи: 25

09-05-2013 дата публикации

METHOD FOR PRODUCING SUBSTITUTED PYRIDIN-2-ONE

Номер: US20130116443A1

Автор: Grossbach Danja, Kroh Walter, Krüger Joachim, Paulsen Holger

Принадлежит: Bayer Intellectual Property GmbH

The present invention relates to a process for the preparation of substituted 3-(2-hydroxyethyl)-1-[4-nitrophenyl]pyridin-2(1H)-ones which serve as important intermediate compounds for producing drugs. 4. The process of claim 1 , wherein Ris methyl and Ris methyl.5. The process or wherein the borane complex is borane-dimethyl sulphide claim 1 , borane-tetrahydrofuran claim 1 , borane diethylaniline or catecholborane.6. The process of wherein the borane complex is used in excess.7. The process of claim 2 , wherein the copper catalyst is provided as a bis(2-pyridinecarboxylato)copper(II) complex or a hydrate thereof claim 2 , or prepared in-situ from copper iodide claim 2 , copper chloride claim 2 , copper(II) bromide claim 2 , copper(II) triflate or copper(II) sulphate with 2-pyridinecarboxylic acid.8. The process of claim 7 , wherein the copper catalyst is provided as a bis(2-pyridinecarboxylato)copper(II) complex or a hydrate thereof.9. The process of wherein the malonic acid ester is diethylmalonic acid ester claim 2 , dibenzylmalonic acid ester claim 2 , di-tert-butylmalonic acid ester or potassium ethylmalonic acid ester.10. The process of claim 9 , wherein the malonic acid ester is diethylmalonic acid ester.11. The process of claims 2 , wherein the base is sodium or potassium tert-butylate claims 2 , potassium claims 2 , sodium or caesium carbonate claims 2 , caesium fluoride or sodium hydride.12. The process of claim 11 , wherein the base is sodium or potassium tert-butylate.14. The compound of claim 13 , wherein Ris methyl and Ris methyl.15. The process of claim 3 , wherein Ris methyl and Ris methyl.16. The process of claim 3 , wherein the copper catalyst is provided as a bis(2-pyridinecarboxylato)copper(II) complex or a hydrate thereof claim 3 , or prepared in-situ from copper iodide claim 3 , copper chloride claim 3 , copper(II) bromide claim 3 , copper(II) triflate or copper(II) sulphate with 2-pyridinecarboxylic acid.17. The process of claim 16 , wherein ...

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Номер записи: 26

16-05-2013 дата публикации

Novel nicotine derivatives

Номер: US20130123106A1

Автор: Gandhi Paresh T.

Принадлежит:

Described are novel nicotine derivatives represented by general formulas (I) and (III), and salts thereof, and herbicide & pharmaceutical compositions containing the same as the active ingredient. The compound and salts thereof can control annual or perennial weed growing on the land where various crops such as rice plant, wheat, cotton and corn grow for a wide period ranging from the pre-emergence to growth in a remarkably small dose. The compounds and salts thereof can be useful as an anti-microbial and anti-fungal agents and also for the treatment of blood pressure, skeletal muscle, attention deficit disorder, mental disorders, schizophrenia, Alzheimer disease, Parkinson's disease and depression. Also described is the preparation of the nicotine derivatives having formula (I) and (III). 2. The compound as claimed in claim 1 , which is selected from the group consisting of:3-(5-(5-acetylthiophen-2-yl)nicotinoyl)-1-methylpyrrolidin-2-one;3-(5-(4-fluorophenyl)nicotinoyl)-1-methylpyrrolidin-2-one;3-(5-(1-methyl-2-oxopyrrolidine-3-carbonyl)pyridin-3-yl)benzaldehyde;1-methyl-3-(5-m-tolylnicotinoyl)pyrrolidin-2-one;3-(5-(4-chlorophenyl)nicotinoyl)-1-methylpyrrolidin-2-one;4-(5-(1-methyl-2-oxopyrrolidine-3-carbonyl)pyridin-3-yl)benzaldehyde;3-(5-(3-methoxyphenyl)nicotinoyl)-1-methylpyrrolidin-2-one;3-(5-(4-methoxyphenyl)nicotinoyl)-1-methylpyrrolidin-2-one;1-methyl-3-(5-p-tolylnicotinoyl)pyrrolidin-2-one;1-methyl-3-(5-phenylnicotinoyl)pyrrolidin-2-one;3-(5-(3-fluorophenyl)nicotinoyl)-1-methylpyrrolidin-2-one;1-methyl-3-(5-(3-nitrophenyl)nicotinoyl)pyrrolidin-2-one;3-(5-(2-methoxyphenyl)nicotinoyl)-1-methylpyrrolidin-2-one;1-methyl-3-(5-o-tolylnicotinoyl)pyrrolidin-2-one;3-(5-(3,5-dichlorophenyl)nicotinoyl)-1-methylpyrrolidin-2-one;1-methyl-3-(5-(naphthalen-1-yl)nicotinoyl)pyrrolidin-2-one;3-(5-(3-acetylphenyl)nicotinoyl)-1-methylpyrrolidin-2-one;3-(5-cyclopropylnicotinoyl)-1-methylpyrrolidin-2-one;1-methyl-3-(5-(naphthalen-2-yl)nicotinoyl)pyrrolidin-2-one;4-(5-(1-methyl- ...

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Номер записи: 27

16-05-2013 дата публикации

PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE

Номер: US20130123304A1

Автор: Gurley Steven, II Bob M., Moore, Mustafa Suni

Принадлежит: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Disclosed are compounds of the formula I: 2. A method according to whereinX is selected from cycloheptyl and cyclohexyl optionally substituted with one to three groups independently selected from halo, carbonyl, hydroxyl, alkyl and alkoxy;Y is selected from carbonyl, dimethylmethylene and hydroxymethylene; andZ is selected from alkyl, cycloalkyl, substituted cycloalkyl, phenyl, substituted phenyl, thiophenyl and substituted thiophenyl.3. A method according to wherein X is selected from cycloheptyl and cyclohexyl optionally substituted with carbonyl or hydroxyl.4. A method according to wherein Y is dimethylmethylene.5. A method according to wherein Z is alkyl claim 2 , phenyl or cycloalkyl.6. A method according to wherein the compound is selected froma) 3-(3-Hydroxycyclohexyl)-6-(2-methyloctan-2-yl)pyridine-2,4-diol;b) 3-(2,4-Dihydroxy-6-(2-methyloctan-2-yl)pyridin-3-yl)cyclohexanone;c) 4-(4,6-Dihydroxy-2-(2-phenylpropan-2-yl)pyridin-5-yl)-6,6-dimethylbicyclo[3.1.1]heptan-2-one;d) 4-Allyl-3-(4,6-dihydroxy-2-(2-phenylpropan-2-yl)pyridin-5-yl)cyclohexanone;e) 6-(2-Cyclohexylpropan-2-yl)-3-(5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)pyridine-2,4-diol; andf) 3-(5-Hydroxy-2-(3-hydroxypropyl)cyclohexyl)-6-(2-(thiophen-2-yl)propan-2-yl)pyridine-2,4-diol. This application is a continuation of and claims priority benefit from application Ser. No. 12/579,282 filed Oct. 13, 2009, which is a continuation in-part of and claims priority benefit from application Ser. No. 12/468,776 filed May 19, 2009 which claims priority benefit from application Ser. No. 61/128,088 filed May 19, 2008, and from prior provisional application Ser. No. 61/105,143 filed Oct. 14, 2008, incorporated herein by reference in its entirety.The classical cannabinoid, delta-9-tetrahydrocannabinol (Δ-THC), is the major active constituent extracted from . The effects of cannabinoids are due to an interaction with specific high-affinity receptors. Presently, two cannabinoid receptors have been characterized: CB-1, a ...

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Номер записи: 28

16-05-2013 дата публикации

METHOD TO CONTROL INSECTS RESISTANT TO COMMON INSECTICIDES

Номер: US20130123307A1

Автор: Gifford James M., Huang Jim X., Loso Michael R., Meade Thomas, Orr Nailah, Rogers Richard B., Sparks Thomas C., Zhu Yuanming

Принадлежит: DOW AGROSCIENCES LLC

N-Substituted sulfoximines are effective at controlling insects resistant to common insecticides. This application claims the benefit of U.S. Provisional Application Ser. No. 60/815,932 filed on Jun. 23, 2006, and the benefit of U.S. non-provisional application Ser. No. 11/704,824 filed on Feb. 9, 2007, now abandoned, and the benefit of U.S. non-provisional application Ser. No. 13/081,886 filed on Apr. 7, 2011, now allowed.The present invention concerns a novel method to control certain insect pests, specifically those that have developed resistance to one or more classes of insecticides, through the use of N-substituted sulfoximines.The development of resistance to insecticides in insect populations is a well recognized phenomenon and there are well documented cases of resistance for all of the major classes of insecticides (Georghiou and Saito, 1984 . Plenum Press, New York; Whalon et al., 2007 , http://www.cips.msu.edu/resistance.rmdb). The reduction in effectiveness of insecticides due to the development of resistance is one of the forces that drives the discovery and development of new insecticides.Predicting whether or not a resistance mechanism that has conferred resistance to an existing insecticide will confer resistance to a novel insecticide (i.e., cross-resistance) is not necessarily a simple matter. In the case where resistance is conferred by a change or modification in the molecular target at which the insecticide acts (i.e., target-site resistance), a novel insecticide that acts at a different target site is unlikely to be affected by the resistance mechanism. Thus, in such a case in which the target site at which a novel chemistry acts is known and the resistance mechanism of concern involves a modification to a different target site, one could predict with some confidence that the resistance mechanism would not confer resistance to the novel chemistry.In contrast to the above, the case where the target site of the novel chemistry is not known or ...

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Номер записи: 29

16-05-2013 дата публикации

SUBSTITUTED ENAMINOCARBONYL COMPOUNDS

Номер: US20130123506A1

Автор: ARNOLD Christian, Beck Michael Edmund, Goergens Ulrich, JESCHKE Peter, MALSAM Olga, Mueller Thomas, Nauen Ralf, PITTA Leonardo, Pontzen Rolf, Reckmann Udo, Sanwald Erich, Schallner Otto, Schenke Thomas, Velten Robert

Принадлежит: Bayer CropScience AG

The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects. 1. A compound of formula (III){'br': None, 'sup': '1', 'sub': '2', 'HN(R)—CH-A\u2003\u2003(III)'}in whichA represents pyrid-3-yl that is optionally substituted in the 6-position by fluorine, chlorine, bromine or trifluoromethyl, or represents 1,3-thiazol-5-yl that is optionally substituted in the 2-position by chlorine; and{'sup': 1', '1, 'sub': 1', '3', '2', '3, 'Rhalo-C-C-alkyl or halo-C-C-alkenyl, with the proviso that Rmust be 2,2-difluoroethyl when A represents pyrid-3-yl that is substituted in the 6-position by chlorine.'}2. A compound of formula (III) according to claim 1 , in whichA represents 6-fluoropyrid-3-yl, 6-chloropyrid-3-yl, 6-bromopyrid-3-yl, 6-trifluoromethylpyrid-3-yl, 2-chloro-1,3-thiazol-5-yl; and{'sup': 1', '1, 'sub': 1', '3', '2', '3, 'Rrepresents fluorine-substituted C-C-alkyl or C-C-alkenyl, with the proviso that Rmust be 2,2-difluoroethyl when A represents 6-chloropyrid-3-yl.'}3. A compound which is N-[(6-chloropyridin-3-yl)methyl]-2 claim 1 ,2-difluoroethane-1-amine. This application is a continuation application of U.S. application Ser. No. 13/334,949, filed Dec. 22, 2011, which is a continuation application of U.S. application Ser. No. 12/295,355, filed Mar. 11, 2009, now U.S. Pat. No. 8,106,211, issued Jan. 31, 2012, which is a §371 National Stage Application of PCT/EP2007/002386 filed Mar. 19, 2007 which claims priority from German Application 10 2006 015 467.3 filed Mar. 31, 2006, the contents of each of these are hereby incorporated by reference in their entireties.1. Field of the InventionThe present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.2. Description of Related ...

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Номер записи: 30

16-05-2013 дата публикации

Pesticidal Mixtures

Номер: US20130125267A1

Автор: Gewehr Markus, LANGEWALD Juergen, Pohlman Matthias, Sikuljak Tatjana

Принадлежит: BASF SE

The present invention, comprising: [(3S,4R,4aR,6S,6aS,12R,12a5,12b5)-3-(cyclopropanecarbonyloxy)-6,12-dihy-droxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12H-benzo[f]pyrano[4,3-b]chromen-4-yl]methyl cydopropanecarboxylate (compound II) and a pesticidal compound II; in synergistic effective amounts. 130-. (canceled)32. The mixture according to claim 31 , wherein the pesticidal compound II is selected from the group consisting of alpha-cypermethrin claim 31 , bifenthrin claim 31 , cypermethrin claim 31 , deltamethrin claim 31 , flucythrinate claim 31 , lambda-cyhalothrin claim 31 , tefluthrin and permethrin.33. The mixture according to claim 31 , wherein the pesticidal compound II is selected from the group consisting of nitenpyram claim 31 , spinosad claim 31 , spinetoram and thiacloprid.34. The mixture according to claim 31 , wherein the pesticidal compound II is ethiprole.35. The mixture according to claim 31 , wherein the pesticidal compound II is selected from the group consisting of abamectin claim 31 , emamectin benzoate claim 31 , milbemectin and lepimectin.36. The mixture according to claim 31 , wherein the pesticidal compound II is selected from the group consisting of chloranthraniliprole and cyantraniliprole.37Bacillus firmus. The mixture according to claim 31 , wherein the pesticidal compound II is CNCM 1-1582.38. The mixture according to claim 31 , wherein the pesticidal compound II is selected from the group consisting of chloranthraniliprole claim 31 , spinosad and abamectin.39. The mixture according to claim 31 , wherein the pesticidal compound II is selected from the group consisting of abamectin claim 31 , bifenthrin claim 31 , alpha-cypermethrin claim 31 , metaflumizone claim 31 , pymetrozine claim 31 , chloranthraniliprole claim 31 , cyanantraniliprole claim 31 , sulfloxaflor claim 31 , spinosad and 4-{[(6-chloropyrid-3-yl)methyl](2 claim 31 ,2-difluoroethyl)amino}furan-2(5H)-on.40. The mixture according ...

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Номер записи: 31

23-05-2013 дата публикации

SYNERGISTIC HERBICIDAL COMPOSITION CONTAINING FLUROXYPYR AND PENOXSULAM, HALOSULFURON-METHYL, IMAZAMOX OR IMAZETHAPYR

Номер: US20130130900A1

Автор: Ellis Andrew Todd, Mann Richard K., McVeigh-Nelson Andrea Christine, Weimer Monte R.

Принадлежит: DOW AGROSCIENCES LLC

An herbicidal synergistic composition containing (a) fluoroxypyr and (b) an ALS inhibitor herbicide, in which the ALS inhibitor herbicide is penoxsulam, halosulfuron-methyl, imazamox or imazethapyr, provides improved post-emergence weed control in rice, cereal and grain crops, pastures, rangelands, IVM and turf. 1. A synergistic herbicidal mixture comprising a herbicidally effective amount of (a) fluoroxypyr , the acid itself , or an agriculturally acceptable salt or ester thereof , and (b) an ALS inhibitor herbicide from the sulfonylurea class of herbicides.2. The mixture of in which fluoroxypyr is the meptyl ester.3. The mixture of in which the ALS inhibitor herbicide is halosufuron-methyl.4. A synergistic herbicidal mixture comprising a herbicidally effective amount of (a) fluoroxypyr claim 1 , the acid itself claim 1 , or an agriculturally acceptable salt or ester thereof claim 1 , and (b) one or more ALS inhibitor herbicides from the imidazolinone class of herbicides.5. The mixture of in which fluoroxypyr is the meptyl ester.6. The mixture of in which the ALS inhibitor herbicides are imazamox and imazethapyr.7. A method for safening centipedegrass and sunflower from the individual harmful effects of penoxsulam and halosufuron-methyl which comprises contacting centipedegrass or sunflower with claim 4 , or applying to the area under cultivation claim 4 , a synergistic mixture of penoxsulam and halosufuron-methyl.8. An herbicidal composition comprising an herbicidally effective amount of the herbicidal mixture of and an agriculturally acceptable adjuvant and/or carrier.9. A method of controlling undesirable vegetation which comprises contacting the vegetation or the locus thereof with or applying to the soil or water to prevent the emergence or growth of vegetation an herbicidally effective amount the herbicidal mixture of .10. A method of controlling undesirable vegetation in rice claim 1 , cereal and grain crops claim 1 , pastures claim 1 , rangelands claim 1 , ...

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Номер записи: 32

23-05-2013 дата публикации

PEST CONTROL COMPOSITION

Номер: US20130131116A1

Автор: Ikari Kaori

Принадлежит: Sumitomo Chemical Company, Limited

A pest control composition comprising a hydrazide compound shown by formula (1) below (in the formula, G, M, Q, Q, Q, Q, R, R, R, Rand m have the same meanings described in the specification) and an ester compound shown by formula (2) below (in the formula, X, X, Xand Xhave the same meanings described in the specification) and a method for controlling pests whereby an effective dose of the hydrazide compound represented by formula (1) and the ester compound represented by formula (II) is applied to a pest or a pest habitat. 2. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , G is a group shown by G-1 claim 1 , Yis an oxygen atom claim 1 , Ris a trifluoromethyl group claim 1 , each of Q claim 1 , Q claim 1 , and Qis a CH group claim 1 , Qis a CRgroup claim 1 , Ris the group defined above claim 1 , (R)is a substituent at 3- and 5-positions claim 1 , m is 2 claim 1 , and Ris a chlorine atom.3. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a hydrogen atom.4. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a hydrogen atom or a methyl group.5. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a halogen atom.6. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a chlorine atom.7. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C2 to C6 alkyl group claim 1 , a C1 to C6 haloalkyl group claim 1 , a C3 to C6 cycloalkyl group claim 1 , or a (C1 to C6 alkoxy) C1 to C6 alkyl group.8. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C2 to C6 alkyl group.9. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C1 to C6 haloalkyl group.10. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C3 to ...

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Номер записи: 33

23-05-2013 дата публикации

PEST CONTROL COMPOSITION

Номер: US20130131118A1

Автор: Ikari Kaori

Принадлежит: Sumitomo Chemical Company, Limited

A pest control composition comprising a hydrazide compound shown by formula (1) below (in the formula, G, M, Q, Q, Q, Q, R, R, R, Rand m have the same meanings described in the specification) and an ester compound shown by formula (2) below (in the formula, X, Xand Xhave the same meanings described in the specification) and a method for controlling pests whereby an effective dose of the hydrazide compound represented by formula (1) and the ester compound represented by formula (II) is applied to a pest or a pest habitat. 2. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , G is a group shown by G-1 claim 1 , Yis an oxygen atom claim 1 , Ris a trifluoromethyl group claim 1 , each of Q claim 1 , Q claim 1 , and Qis a CH group claim 1 , Qis a CRgroup claim 1 , Ris the group defined above claim 1 , (R)is a substituent at 3- and 5-positions claim 1 , m is 2 claim 1 , and Ris a chlorine atom.3. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a hydrogen atom.4. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a hydrogen atom or a methyl group.5. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a halogen atom.6. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a chlorine atom.7. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C2 to C6 alkyl group claim 1 , a C1 to C6 haloalkyl group claim 1 , a C3 to C6 cycloalkyl group claim 1 , or a (C1 to C6 alkoxy) C1 to C6 alkyl group.8. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C2 to C6 alkyl group.9. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C1 to C6 haloalkyl group.10. The pest control composition according to claim 1 , wherein in the formula (1) claim 1 , Ris a C3 to C6 ...

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Номер записи: 34

30-05-2013 дата публикации

HYDROPHILIZED ANTIMICROBIAL POLYMERS

Номер: US20130136783A1

Автор: Sellenet Philippe H., Stratton Thomas R., Youngblood Jeffrey P.

Принадлежит: PURDUE RESEARCH FOUNDATION

A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal or antimicrobial polymers, methods for rendering materials bactericidal or antimicrobial, and methods for using bactericidal or antimicrobial compositions to kill or reduce bacterial or microbial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; fibers; paper; and/or wound dressing. 1. A device comprising a substrate having thereon a polymer represented as a free-radical copolymerization product of(a) a first monomer comprising a hydrophilic monomer having an acrylate group(b) a second monomer comprising at least one monomer selected from a pyridinium-type monomer having a quaternized nitrogen and a pyridine-type monomer having a nitrogen quaternizable with an alkyl halide, the second monomer additionally having a vinyl group(c) said polymer in quaternized form being more bactericidal in an aqueous solution than the first monomer or a homopolymer formed from the first monomer, and said polymer being more bactericidal in an aqueous solution than the second monomer or a homopolymer formed from the second monomer.2. A device according to claim 1 , wherein the second monomer comprises a member of the group consisting of vinylpyridine and quaternized vinylpyridinium.3. A device according to claim 1 , wherein the first monomer comprises at least one selected from hydroxyethylmethacylate claim 1 , polyethylene glycol) rnethacrylate and polyethylene glycol) methyl ether methacrylate.4. A device according to claim 3 , wherein the second monomer comprises a member of the group consisting of vinylpyridine and quaternized vinylpyridinium.5. A ...

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Номер записи: 35

30-05-2013 дата публикации

SUB-MICRON COMPOSITIONS

Номер: US20130136849A1

Автор: Maynard Nigel Paul

Принадлежит: MATTERSMITHS TECHNOLOGIES LIMITED

The invention relates to sub-micron compositions, and methods of preparing such compositions, in particular for the treatment of substrates against biological degradation biological pests. 1. A method of preparing a composition comprising sub-micron particles , containing or coated with an active agent(s) , the method comprising at least the steps of:a) (i) dispersing sub-micron particles in a solvent(s);(ii) adding to the dispersion, a formulation containing the active agent(s) dissolved in a suitable solvent in a manner sufficient to achieve substantial uniformity of the mixture (or vice versa); orb) dispersing sub-micron particles in a solvent(s) whilst concurrently or sequentially dissolving an active agent in said solvent in a manner sufficient to achieve substantial uniformity of the mixture; andc) altering the physicochemical environment within the dispersion to cause the active agent to fall out of solution as a sub-micron layer in or on the sub-micron particles.2. The method according to claim 1 , wherein the active agent is a biocide claim 1 , colouring agent or a water repellent agent or a mixture thereof.3. The method according to claim 1 , wherein the alteration in the physicochemical environment can be by one or more of; change in pH claim 1 , introduction of another moiety which reacts with the active agent to cause precipitation claim 1 , heating which can change the isoelectric point claim 1 , heating which can remove sufficient solvent such that the solubility product of the active agent is exceeded claim 1 , addition of a non-solvent of the active agent to cause precipitation or addition of a solute which causes precipitation of the active agent.4. The method according to claim 1 , wherein the physicochemical environment is altered while agitating the result of step (a) (ii) or (b) such that the active agent precipitates as a sub-micron layer on the sub-micron particles and/or within any porosity in the sub-micron particles.5. The method according ...

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Номер записи: 36

30-05-2013 дата публикации

ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF

Номер: US20130137732A1

Автор: "OReilly Mark", Burwell Steve R., Busch Fredrick

Принадлежит: BYOCOAT ENTERPRISES, INC.

This disclosure provides generally for antimicrobial compositions and methods for reducing or preventing microorganism growth, viability, or survival, which are useful for treating poultry, meat, seafood, vegetables, legumes, fruit, crops, and other products for human or animal consumption. For example, the compositions can include GRAS (Generally Recognized As Safe) antimicrobial components such as ε-poly-L-lysine in combination with at least one quaternary ammonium salt, including an aliphatic heteroaryl ammonium salt such as cetylpyridinium chloride. 1. An antimicrobial composition comprising:a) ε-poly-L-lysine; andb) at least one quaternary ammonium compound.2. An antimicrobial composition according to claim 1 , wherein the ε-poly-L-lysine contains from about 20 to about 40 L-lysine residues.3. An antimicrobial composition according to claim 1 , wherein each of the at least one quaternary ammonium compound is selected independently from an aliphatic heteroaryl salt claim 1 , an aliphatic benzyl dialkyl ammonium salt claim 1 , a dialiphatic dialkyl ammonium salt claim 1 , and a tetraalkyl ammonium salt.4. An antimicrobial composition according to claim 1 , wherein each of the at least one quaternary ammonium compound is selected independently from an aliphatic heteroaryl salt and an aliphatic benzyl dialkyl ammonium salt.5. An antimicrobial composition according to claim 3 , wherein the aliphatic heteroaryl salt is selected from cetylpyridinium chloride claim 3 , cetylpyridinium bromide claim 3 , and a combination thereof.6. An antimicrobial composition according to claim 3 , wherein the aliphatic benzyl dialkyl ammonium salt is selected from alkyl dimethyl benzyl ammonium halide claim 3 , alkyl diethyl benzyl ammonium halide claim 3 , alkyl methylethyl benzyl ammonium halide claim 3 , and a combination thereof.7. An antimicrobial composition according to claim 3 , wherein the dialiphatic dialkyl ammonium salt is selected from didodecyl dimethyl ammonium halide ...

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Номер записи: 37

06-06-2013 дата публикации

HERBICIDAL COMPOSITION CONTAINING CERTAIN PYRIDINE CARBOXYLIC ACIDS AND (2,4-DICHLOROPHENOXY)ACETIC ACID

Номер: US20130143738A1

Автор: Carranza Garzon Nelson M., Masters Robert A., Ovalle Daniel, Paniagua Leonardo, Reichert Alberto, Rojas-Calvo Carlos E.

Принадлежит: DOW AGROSCIENCES LLC

Herbicidal compositions comprising 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid (I) or a derivative thereof and 2,4-D or a derivative thereof. 2. The composition of claim 1 , wherein the composition further comprises a herbicide safener.3. The composition of claim 2 , wherein the herbicide safener is cloquintocet mexyl or acid.4. The composition of claim 1 , wherein (a) is the benzyl ester claim 1 , methyl ester claim 1 , or potassium salt of the compound of formula (I).5. The composition of claim 4 , wherein (a) is the methyl ester.6. The composition of claim 4 , wherein (b) is the dimethyl amine salt of 2 claim 4 ,4 D.7. The composition of claim 5 , wherein (b) is the dimethyl amine salt of 2 claim 5 ,4 D.8. The composition of claim 1 , wherein the carboxylic acid equivalent weight ratio of the compound of formula (I) or salt claim 1 , ester or amide thereof to 2 claim 1 ,4-D or salt claim 1 , ester claim 1 , or amide thereof is from 1:100 to 1:3.5.9. The composition of claim 1 , wherein the carboxylic acid equivalent weight ratio of the compound of formula (I) or salt claim 1 , ester or amide thereof to 2 claim 1 ,4-D or salt claim 1 , ester claim 1 , or amide thereof is from 1:56 to 1:7.10. The composition of claim 5 , wherein the carboxylic acid equivalent weight ratio of the methyl ester of the compound of formula (I) to 2 claim 5 ,4-D or salt claim 5 , ester claim 5 , or amide thereof is from about 1:56 to about 1:7.11. The composition of claim 10 , wherein the carboxylic acid equivalent weight ratio is from about 1:27 to about 1:14.12. The composition of claim 4 , wherein (a) is the benzyl ester claim 4 , and the carboxylic acid equivalent weight ratio of the benzyl ester of the compound of formula (I) to 2 claim 4 ,4-D or salt claim 4 , ester claim 4 , or amide thereof is from about 1:28 to about 1:7.13. The composition of claim 4 , wherein (a) is the potassium salt claim 4 , and the carboxylic acid equivalent weight ...

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Номер записи: 38

06-06-2013 дата публикации

HERBICIDAL COMPOSITION CONTAINING 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or derivative thereof AND FLUROXYPYR or derivatives thereof

Номер: US20130143739A1

Автор: Carranza Garzon Nelson M., Masters Robert A., Ovalle Daniel, Paniagua Leonardo, Reichert Alberto, Rojas-Calvo Carlos E.

Принадлежит: DOW AGROSCIENCES LLC

Herbicidal compositions comprising and methods of controlling desirable vegetation utilizing 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or an agriculturally acceptable ester, amide, or salt thereof and (b) fluroxypyr or an agriculturally acceptable ester, amide, or salt thereof. 2. The composition of claim 1 , wherein the composition further comprises a herbicide safener.3. The composition of claim 2 , wherein the safener is cloquintocet acid or cloquintocet mexyl.4. The composition of claim 1 , wherein (a) is a C-Cor benzyl ester of the compound of formula (I).5. The composition of claim 4 , wherein (a) is the methyl ester of the compound of formula (I).6. The composition of claim 5 , wherein (b) is fluroxypyr meptyl.7. The composition of claim 1 , wherein the carboxylic acid equivalent weight ratio of (a) to (b) is from about 1:1 to about 1:62.8. The composition of claim 1 , wherein the carboxylic acid equivalent weight ratio of (a) to (b) is from about 1:3 to about 1:31.9. The composition of claim 6 , wherein the carboxylic acid equivalent weight ratio of (a) to (b) is from about 1:1 to about 1:62.10. The composition of claim 6 , wherein the carboxylic acid equivalent weight ratio of (a) to (b) is from about 1:3 to about 1:31.11. The composition of claim 1 , wherein (a) is the triethylammonium salt of the compound of formula (I).12. The composition of claim 11 , wherein (b) is fluroxypyr meptyl.13. The composition of claim 12 , wherein the carboxylic acid equivalent weight ratio of (a) to (b) is from about 1:6 to about 1:17.14. The method of controlling undesirable vegetation comprising contacting the undesirable vegetation claim 1 , the area adjacent to the undesirable vegetation claim 1 , or soil a herbicidally effective amount of the composition of .15. The method of claim 14 , wherein (a) is the methyl ester of the compound of formula (I) and (b) is fluroxypyr meptyl.16. The method of claim 14 , wherein the undesirable ...

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Номер записи: 39

06-06-2013 дата публикации

COMPOSITION FOR REPELLING AND DETERRING VERMIN

Номер: US20130143924A1

Автор: Bouvier Jacques, Cavaliero Tania, DUCRAY Pierre, Lohrmann Maike

Принадлежит:

The present invention is directed to a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula (I) 3. Process according to claim 2 , wherein R1 is hydrogen or halogen; m is 1 or 2 claim 2 , R2 is hydrogen claim 2 , C-C-alkyl claim 2 , or phenyl; and R4 is hydrogen or acetyl.5. Process according to claim 4 , wherein R1 is hydrogen or halogen; m is 1 or 2 claim 4 , R2 is hydrogen claim 4 , C-C-alkyl claim 4 , or phenyl; and R4 is hydrogen or acetyl.7. Process according to claim 6 , wherein R1 is hydrogen or halogen; m is 1 or 2 claim 6 , R2 is hydrogen claim 6 , C-C-alkyl claim 6 , or phenyl; and R4 is hydrogen or acetyl.9. Process according to claim 8 , wherein R1 is hydrogen or halogen; m is 1 or 2 claim 8 , R2 is hydrogen claim 8 , C-C-alkyl claim 8 , or phenyl; and R4 is hydrogen or acetyl.1012-. (canceled)13. Process according to whereby the compound of formula I is applied in the form of a pour-on or spot-on formulation.14. Process for deterring vermin from places or materials where they are not wanted claim 1 , whereby an effective amount of a compound of formula I according to is applied to the place or to the material claim 1 , at which one would like to deter insect pests claim 1 , tics or mites.15. Composition for repelling vermin claim 1 , comprising a compound of formula I according to and a spreading additive.16. Process for the preparation of a composition for repelling vermin claim 1 , whereby a compound of formula I according to is mixed with a spreading additive.1718-. (canceled) The present invention relates essentially to a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula I shown below. Furthermore, it relates to corresponding vermin-repelling compositions which contain these substances as the active ingredient, to compounds of formula I for the preparation of vermin-deterring ...

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Номер записи: 40

20-06-2013 дата публикации

HERBICIDAL COMPOSITION CONTAINING FLUROXYPYR AND GLYPHOSATE

Номер: US20130157852A1

Автор: Mann Richard K.

Принадлежит: DOW AGROSCIENCES LLC

Herbicidal compositions containing fluoroxypyr and glyphosate. 1. A herbicidal composition comprising a herbicidally effective amount of (a) fluoroxypyr or salt or ester thereof and (b) glyphosate or salt or ester thereof.2. The composition of claim 1 , wherein (a) is fluoroxypyr meptyl and (b) is glyphosate ammonium.3. The composition of claim 1 , wherein the carboxylic acid equivalent weight ratio of fluoroxypyr or salt or ester thereof to glyphosate or salt or ester thereof is from 2:1 to 1:40.4. The composition of claim 3 , wherein the carboxylic acid equivalent weight ratio is from 1:1 to 1:20.5. The composition of claim 4 , wherein the carboxylic acid equivalent weight ratio is from 1:2.5 to 1:10.6. The composition of claim 2 , wherein the carboxylic acid equivalent weight ratio of fluoroxypyr meptyl to glyphosate ammonium is from 2:1 to 1:40.7. The composition of claim 2 , wherein the carboxylic acid equivalent weight ratio of fluoroxypyr meptyl to glyphosate ammonium is from 1:1 to 1:20.8. The composition of claim 2 , wherein the carboxylic acid equivalent weight ratio of fluoroxypyr meptyl to glyphosate ammonium is from 1:2.5 to 1:10.9. The composition of claim 1 , further comprising a safener.10. The composition of claim 1 , further comprising one or more additional herbicides.11. The composition of claim 1 , wherein the composition further comprises an agriculturally acceptable adjuvant or carrier.12. A method of treating undesirable vegetation comprising contacting the vegetation claim 1 , locus of the vegetation claim 1 , soil claim 1 , or water a herbicidally effective amount of the composition of .13. A method of treating undesirable vegetation comprising contacting the vegetation claim 8 , locus of the vegetation claim 8 , soil claim 8 , or water a herbicidally effective amount of the composition of .14. A method of treating undesirable vegetation comprising contacting the vegetation claim 8 , locus of the vegetation claim 8 , soil claim 8 , or water ...

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Номер записи: 41

20-06-2013 дата публикации

HERBICIDAL PICOLINIC ACID SALT COMPOSITION

Номер: US20130157862A1

Автор: PANAYI Aristos, SAYER Chad Richard Ord

Принадлежит: NUFARM AUSTRALIA LIMITED

A herbicidal concentrate composition comprising a mixture of the monomethylamine and dimethylamine salts of at least one picolinic acid herbicide of formula (Ia): wherein Xis selected from hydrogen and amino. 2. A herbicidal composition according to wherein the herbicide is clopyralid.3. A herbicidal composition according to wherein the mixture of salts is present in aqueous solution of concentration of at least 300 g/L claim 1 , based on herbicidal acid equivalent.4. A herbicidal composition according to wherein the mixture of salts is present in aqueous solution of concentration of at least 500 g/L claim 1 , based on herbicidal acid equivalent.5. A herbicidal composition according to wherein the mixture of salts is present in aqueous solution of concentration of at least 700 g/L claim 1 , based on herbicidal acid equivalent.6. A herbicidal composition according to wherein the mole ratio is in the range of 70%-90% DMA to 30%-10% MMA.7. A composition consisting essentially of:i) clopyralid in the form of the monomethylamine salt and clopyralid in the form of the dimethylamine salt wherein the molar ratio of monomethylamine to dimethylamine is preferably in the range of from 10:90 to 90:10;ii) water;iii) no more than 10% by weight based on the total weight of the composition of additives selected from surfactants and compatibility agents; andiv) wherein the concentration of picolinic acid salt herbicide in the aqueous composition is at least 500 g/L based on herbicidal acid equivalent.8. A composition according to wherein the ratio is from 70%-90% DMA to 30%-10% MMA.9. A composition according to wherein the concentration of clopyralid salt herbicide is at least 500 g/L claim 8 , based on herbicidal acid equivalent.10. A composition according to wherein the concentration of clopyralid salt herbicide is at least 700 g/L claim 9 , based on herbicidal acid equivalent.11. A composition according to wherein the composition comprises casein in an amount of from 0.01 to 5% ...

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Номер записи: 42

20-06-2013 дата публикации

Methylene Urea Derivatives

Номер: US20130158076A1

Автор: Amendt Christiane, Buchstaller Hans-Peter, Finsinger Dirk, Grell Matthias, SCHADT Oliver, Sirrenberg Christian, Wiesner Matthias, Zenke Frank

Принадлежит: Merck Patent GmBH

The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. 1. A compound of formula I{'br': None, 'A-D-B\u2003\u2003(I)'}whereinD is a bivalent methylene urea moiety, or a derivative thereof,{'sub': α', 'β', 'x', 'y', 'z, 'A is a unsubstituted or substituted moiety of up to 40 carbon atoms of the formula: -L-(M-L′), where L is a 5, 6 or 7 membered cyclic structure, selected from the group consisting of aryl, heteroaryl, arylene and heteroarylene, bound directly to D, L′ comprises an optionally substituted cyclic moiety having at least 5 members, preferably selected from the group consisting of aryl, heteroaryl, aralkyl, cycloalkyl and heterocyclyl, M is a bond or a bridging group haying at least one atom, α is an integer of from 1-4; and each cyclic structure of L and L′ contains 0-4 members of the group consisting of nitrogen, oxygen and sulfur, wherein L′ is substituted by at least one substituent selected from the group consisting of —SOR, —C(O)R, and —C(NR)R'}{'sub': 'y', 'B is a substituted or unsubstituted, up to tricyclic aryl or heteroaryl moiety of up to 30 carbon atoms, comprising at least one 5-, 6-, or 7-membered cyclic structure, a 5- or 6-membered cyclic structure, bound directly to D containing 0-4 members of the croup consisting of nitrogen, oxygen and sulfur, wherein said cyclic structure directly bound to D is selected from the group consisting of aryl, heteroaryl and heterocyclyl, Ris hydrogen or a carbon based moiety of up to 24 carbon atoms optionally containing heteroatoms selected from N, S and O and optionally halosubstituted, up to per halo,'}{'sub': 'z', 'Ris hydrogen or a carbon based moiety of up to 30 carbon atoms optionally containing heteroatoms selected from N, S ...

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Номер записи: 43

27-06-2013 дата публикации

PEST CONTROL AGENT

Номер: US20130165482A1

Автор: Horikoshi Ryo, Kagabu Shinzo, Kitsuda Shigeki, Mitomi Masaaki, Nomura Masahiro, Onozaki Yasumichi

Принадлежит: MEIJI SEIKA PHARMA CO., LTD.

Specific amine derivatives have been found to possess excellent activities as pest control agents. 124-. (canceled)26. The amine derivative or a salt thereof according to claim 25 , wherein Y in formula (Ie′) is a hydrogen atom or a halogen atom.27. The amine derivative or a salt thereof according to claim 25 , wherein the compound of formula (Ie′) is a compound selected from the group consisting of N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2 claim 25 ,2-trifluoroacetamide claim 25 , N-[1-((6-chloro-5-fluoropyridin-3-yl)methyl)pyridin-2(1H)-ylidine]-2 claim 25 ,2 claim 25 ,2-trifluoroacetamide claim 25 , N-[1-((6-fluoropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2 claim 25 ,2-trifluoroacetamide claim 25 , N-[1-((6-bromopyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2 claim 25 ,2-trifluoroacetamide claim 25 , N-[1-(1-(6-chloropyridin-3-yl)ethyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2 claim 25 ,2-trifluoroacetamide claim 25 , N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2-difluoroacetamide claim 25 , 2-chloro-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2-difluoroacetamide claim 25 , N-[1-((2-chloropyrimidin-5-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2 claim 25 ,2-trifluoroacetamide and N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2 claim 25 ,2 claim 25 ,3 claim 25 ,3 claim 25 ,3-pentafluoropropanamide.28. The amine derivative or a salt thereof according to claim 25 , which has a pest control activity on at least one type of pest selected from the group consisting of lepidopterous pests claim 25 , hemipterous pests claim 25 , thysanopterous pests claim 25 , dipterous pests claim 25 , coleopterous pests claim 25 , animal parasitic fleas and ticks claim 25 , and canine heartworms.29. A pest control agent comprising at least one amine derivative or a salt thereof according to .32. The method according to or claim 25 , wherein the pest is an agricultural/ ...

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Номер записи: 44

04-07-2013 дата публикации

HERBICIDAL COMPOSITIONS

Номер: US20130172188A1

Автор: BRISTOW James Timothy

Принадлежит: ROTAM AGROCHEM INTERNATIONAL CO.,LTD

A herbicidal composition comprising an aqueous suspension of microcapsules, having a capsule wall of a porous condensate polymer, and containing a solution of fluoroxypyr in a rosin solvent system comprising rosin and/or a rosin derivative. There is also provided a herbicidal composition comprising microcapsules, having a capsule wall of a porous condensate polymer, and containing fluoroxypyr and a solvent comprising rosin and/or a rosin derivative. A method of preparing a herbicidal composition is also disclosed, comprising providing a water immiscible phase comprising fluoroxypyr and an isocyanate dissolved in a rosin solvent system comprising rosin and/or a rosin derivative; providing an aqueous phase comprising one or more surfactants; combining the water immiscible phase and the aqueous phase to form a dispersion of the water immiscible phase in the aqueous phase; adding to the resulting dispersion an amine, thereby forming microcapsules of polyurea containing droplets of the water immiscible phase; and curing the microcapsules. 1. A herbicidal composition comprising an aqueous suspension of microcapsules , the microcapsules having a capsule wall of a porous condensate polymer , wherein the microcapsules contain a solution of fluoroxypyr in a rosin solvent system comprising rosin and/or a rosin derivative.2. The composition according to claim 1 , wherein fluoroxypyr is present in the composition in an amount of at least 20% by weight.3. The composition according to claim 2 , wherein fluoroxypyr is present in the composition in an amount of at least 50% by weight.4. The composition according to claim 1 , wherein the rosin solvent system consists essentially of rosin and/or a rosin derivative.5. The composition according to claim 1 , wherein the rosin solvent system comprises a rosin derivative selected from hydrogenated rosin claim 1 , polymerized rosin claim 1 , esters of rosin or hydrogenated rosin claim 1 , in particular methyl esters of rosin or of ...

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Номер записи: 45

04-07-2013 дата публикации

METHOD FOR PRODUCTION OF F-18 LABELED AMYLOID BETA LIGANDS

Номер: US20130172620A1

Автор: Berndt Mathias, FRIEBE Matthias, Hultsch Christina, PATT Marianne, Samson Fabrice, Schildan Andreas, Smuda Christoph

Принадлежит: PIRAMAL IMAGING SA

This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives. 2. A method according to claim 1 , wherein PG is selected from the group consisting of:a) Boc,b) Trityl andc) 4-Methoxytrityl.3. A method according to claim 1 , wherein LG is selected from the group consisting of:a) Halogen andb) Sulfonyloxy,Wherein Halogen is chloro, bromo or iodo.4. A method according to claim 3 , wherein Sulfonyloxy is selected from the group consisting of:a) Methanesulfonyloxy,b) p-Toluenesulfonyloxy,c) (4-Nitrophenyl)sulfonyloxy,d) (4-Bromophenyl)sulfonyloxy.5. A method according to claim 1 , wherein n=3 and X═CH.6. A method according to claim 1 , wherein n=3 claim 1 , X═CH claim 1 , R=Boc claim 1 , and LG=Methanesulfonyloxy.7. A method according to claim 1 , wherein the radiofluorination reaction is carried out in a mixture of acetonitrile and co-solvents claim 1 , wherein the percentage of acetonitrile is at least 50%.8. A method according to claim 7 , wherein the radiofluorination reaction is carried out in a mixture of acetonitrile and co-solvents claim 7 , wherein the percentage of acetonitrile is at least 70%.9. A method according to claim 7 , wherein the radiofluorination reaction is carried out in a mixture of acetonitrile and co-solvents claim 7 , wherein the percentage of acetonitrile is at least 90%.10. A method according to claim 1 , wherein 1.5-75 μmol claim 1 , preferably 10-30 μmol and even more preferably 12-25 μmol of compound of Formula II are used in Step 1.11. A method according to claim 1 , wherein the method is performed as a fully automated process.12. A kit claim 1 , comprising a sealed vial comprising a predetermined quantity of a compound of formula II of and a sealed vial comprising acetonitrile or acetonitrile and a co-solvent.13. A method according to claim 1 , wherein Step 3 comprises a purification by HPLC.14. A method according to claim 13 , wherein the HPLC solvent used in ...

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Номер записи: 46

11-07-2013 дата публикации

HERBICIDAL COMPOSITIONS

Номер: US20130178365A1

Автор: BRISTOW James Timothy

Принадлежит: ROTAM AGROCHEM INTERNATIONAL CO., LTD.

A herbicidal composition comprising microcapsules containing a solution of at least one herbicidally active compound that is solid at room temperature and with a melting point below 190° C., other than a sulfonylurea, preferably fluroxypyr, in a polyhydric alcohol ester solvent system; suspended in a continuous phase having suspended therein finely divided particles of one or more sulfonylureas. A method for preparing the composition comprising i) providing a water-immiscible liquid phase comprising a polyhydric alcohol ester, an active compound that is solid at room temperature and with melting point below 190° C., and a first wall forming component; ii) providing an aqueous phase comprising water and, optionally, one or more surface active agents; iii) combining the water immiscible phase with the aqueous phase to form a dispersion of the water-immiscible phase in the continuous aqueous phase; iv) adding a second wall forming component to the resulting mixture, causing interfacial polymerization of the first and second wall forming components and encapsulating droplets of the water-immiscible phase; v) providing a suspension of a sulfonylurea in a polyhydric alcohol ester, optionally with one or more dispersants; and vi) combining the composition prepared in step (iv) with the composition prepared in step (v). 1. A herbicidal composition comprising microcapsules containing a solution of at least one herbicidally active compound that is solid at room temperature and with a melting point below 190° C. , said herbicidally active compound being other than a sulfonylurea , in a polyhyrdric alcohol ester solvent system; the microcapsules being suspended in a continuous phase of a polyhydric alcohol solvent system having suspended therein finely divided particles of one or more sulfonylureas.2. The herbicidal composition according to claim 1 , wherein the polyhydric alcohol ester solvent system consists essentially of one or more polyhydric alcohol esters.3. The ...

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Номер записи: 47

18-07-2013 дата публикации

SYNERGISTIC PESTICIDE COMPOSITIONS

Номер: US20130183390A1

Автор: Baker Robert B., Bao Nanggang N., Baur Peter, Kent Gerald J., Koufas Deborah A., REID Byron L.

Принадлежит: BAYER CROPSCIENCE LP

The present invention relates to compositions that include a combination of one or more pesticides and one or more adjuvants. 1. A composition comprising an active ingredient comprising a pyrethrum and/or a pyrethroid and dibutyl sebacate.2. A composition comprising an active ingredient comprising a pyrethrum and/or a pyrethroid and oleic acid.3. A composition comprising an active ingredient comprising a pyrethrum and/or a pyrethroid and benzenepropanoic acid.4. A composition consisting of an active ingredient comprising a pyrethrum and/or a pyrethroid and methyl oleate.5. A composition comprising an active ingredient comprising a pyrethrum and/or a pyrethroid and methyl linoleate.6. A composition comprising an active ingredient comprising a pyrethrum and/or a pyrethroid and butylated hydroxyanisole (BHA).7. A composition comprising an active ingredient comprising a pyrethrum and/or a pyrethroid and two or more sebacates , wherein the sebacates are hindered amine light stabilizers and wherein said composition does not include an attractant.8. The composition of claim 7 , wherein the sebacates are bis(1 claim 7 ,2 claim 7 ,2 claim 7 ,6 claim 7 ,6-pentamethyl-4-piperidinyl)sebacate and methyl(1 claim 7 ,2 claim 7 ,2 claim 7 ,6 claim 7 ,6-pentamethyl-4-piperidinyl)sebacate.9. The composition of claim 1 , wherein the pyrethrum comprises pyrethrin.10. The composition of claim 1 , wherein pyrethroid comprises deltamethrin claim 1 , permethrin claim 1 , β-cyfluthrin claim 1 , bifenthrin claim 1 , and/or resmethrin.1110. A method for controlling or preventing a pest infestation comprising administering the composition of anyone of - to a place in need thereof. This application is a Divisional of U.S. application Ser. No. 12/410,840, filed Mar. 25, 2009, the contents of which is incorporated by reference herein in its entirety, which claims priority to U.S. Provisional Application No. 61/163,206, filed Mar. 25, 2009 and U.S. Provisional Application No. 61/072,778, filed Apr. ...

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Номер записи: 48

18-07-2013 дата публикации

FUNGICIDAL ACTIVE SUBSTANCE COMBINATIONS

Номер: US20130184319A1

Автор: ASSMANN Lutz, Dahmen Peter, Pontzen Rolf, Sawada Haruko, Wachendorff-Neumann Ulrike

Принадлежит: Bayer CropScience AG

The invention relates to novel fungicidally active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide and active compounds listed in the disclosure. 2. A composition according to wherein in the active compound combinations the weight ratio of active compound of the formula (I) toactive compound of formula (II) is between 1:0.1 and 1:20,active compound of formula (V) is between 1:0.1 and 1:100,active compound of formula (VI) is between 1:0.1 and 1:100,active compound of formula (VII) is between 1:0.1 and 1:100,active compound of formula (VIII) is between 1:0.1 and 1:100,active compound of formula (IX) is between 1:0.1 and 1:100,active compound of formula (X-a) or (X-b) is between 1:0.1 and 1:100,active compound of formula (XI) is between 1:0.1 and 1:100,active compound of formula (XII) is between 1:0.1 and 1:100, andactive compound of formula (XIV) is between 1:0.1 and 1:100.3. A method for controlling fungi comprising applying an effective amount of an active compound combination according to to the fungi and/or their habitat.5. A process for preparing a fungicidal composition comprising mixing an active compound combination according to with one or more extenders and/or surfactants.6. A fungicidal composition according to wherein component (b) is a compound of formula (V).7. A method for controlling fungi comprising applying an effective amount of an active compound combination according to to the fungi and/or their habitat. This application is a continuation application of U.S. application Ser. No. 12/779,362, filed May 13, 2010 which is a National Stage filing of PCT/EP2004/008072, filed Jul. 20, 2004 which claims priority from German Application Number 103 33 373.8 filed Jul. 23, 2003 the contents of which are incorporated by reference in their entireties.1. Field of InventionThe invention relates to active compound combinations which comprise the known 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide on the one hand and other known ...

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Номер записи: 49

25-07-2013 дата публикации

TREATMENT OF OPHTHALMIC CONDITIONS WITH FLUORENONE DERIVATIVES

Номер: US20130189246A1

Автор: Petrukhin Konstantin

Принадлежит: The Trustees of Columbia University in the City of New York

Provided are compositions and methods for treatment of ophthalmic conditions, such as retinal detachment and age-related macular degeneration. Various fluorenone derivatives described herein can stimulate fluid removal from the subretinal space and down-regulate reactive gliosis. Administration of compounds described herein can provide an alternative or an adjunct to an invasive procedure to reattach the retina. 2. The method according to claim 1 , wherein X is selected from the group consisting of propyl claim 1 , hydroxyethyl claim 1 , haloethyl claim 1 , and cycloalkyl having less than 6 carbons.32. The method according to any one of - wherein R is a heterocyclic-alkyl group.43. The method according to any one of - wherein R is an oxazinyl-alkyl group.5. The method according to wherein the compound is selected from the group consisting of:2-{[(5,6-dichloro-2,3,9,9a-tetrahydro-3-oxo-9a-propyl-1H-fluoren-7-yl)oxy]methyl}-tetrahydro-1,3-oxazine;2-{[(5,6-dichloro-2,3,9,9a-tetrahydro-3-oxo-9a-propyl-1H-fluoren-7-yl)oxy]methyl}oxazoline;2-{[(5,6-dichloro-2,3,9,9a-tetrahydro-3-oxo-9a-propyl-1H-fluoren-7-yl)oxy]methyl}thiazoline;enantiomers thereof; andpharmaceutically acceptable salts thereof.63. The method according to any one of - wherein R is a pyridyl-alkyl group.7. The method according to wherein the compound is selected from the group consisting of:5,6-dichloro-9a-propyl-7-(2-pyridylmethoxy)-2,3,9,9a-tetrahydro-1H-fluoren-3-one;5,6-dichloro-9a-propyl-7-(3-pyridylmethoxy)-2,3,9,9a-tetrahydro-1H-fluoren-3-one;5,6-dichloro-9a-propyl-7-(4-pyridylmethoxy)-2,3,9,9a-tetrahydro-1H-fluoren-3-one;enantiomers thereof; andpharmaceutically acceptable salts thereof.82. The method according to any one of - wherein R is a heterocyclicaralkyl group.9. The method according to wherein the compound is selected from the group consisting of:5,6-dichloro-2,3,9,9a-tetrahydro-7-[4-(2-oxazolinyl)-phenylmethoxy]-9a-propyl-1H-fluoren-3-one;5,6-dichloro-2,3,9,9a-tetrahydro-7-[3-(2-oxazolinyl ...

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Номер записи: 50

25-07-2013 дата публикации

SOLID HERBICIDE COMPOSITIONS WITH BUILT-IN ADJUVANT

Номер: US20130190176A1

Автор: Dave Hiteshkumar, Li Mei, LIU Lei, Ouse David

Принадлежит: DOW AGROSCIENCES LLC

The present disclosure concerns improved solid herbicidal compositions, such as granules and powders, containing built-in adjuvant, which have improved stability and exhibit acceptable herbicidal efficacy when used to control weeds in flooded rice paddies or fields, or cereal crop fields. 2. The composition of claim 1 , wherein the solid herbicidal composition is a powder.3. The composition of claim 1 , wherein the solid herbicidal composition is a granule.4. The composition of claim 1 , further comprising one or more additional inert ingredients.5. The composition of claim 1 , further comprising one or more additional agriculturally active ingredients.8. The composition of claim 1 , in which the built-in adjuvant is one or more of water-immiscible organic liquid.9. The composition of claim 1 , in which the built-in adjuvant is one or more of a petroleum derived paraffinic hydrocarbon claim 1 , a petroleum derived aromatic hydrocarbon claim 1 , a plant derived oil claim 1 , or a C-Cester of a plant derived oil.10. The composition of claim 1 , in which the build-in adjuvant is one or more of a seed oil claim 1 , or a C-Cesters of plant derived oil.11. The composition of claim 1 , in which the build-in adjuvant is methyl soyate.12. The composition of claim 1 , wherein the build-in adjuvant is in an amount of from about 200 g/kg to about 600 g/kg relative to the total weight of the composition.13. The composition of claim 1 , wherein the build-in adjuvant is in an amount of from about 300 g/kg to about 600 g/kg relative to the total weight of the composition.14. The composition of claim 1 , in which the solid claim 1 , water soluble polymer or oligomer is one or more of a lignosulfonate claim 1 , a polyvinyl alcohol with a degree of hydrolysis from about 87 to about 99 percent claim 1 , or an alkyl naphthalene sulfonate formaldehyde condensate.15. The composition of claim 1 , in which the solid claim 1 , water soluble polymer or oligomer is one or more of polyvinyl ...

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Номер записи: 51

25-07-2013 дата публикации

PEST CONTROLLING COMPOSITION AND METHOD FOR CONTROLLING PEST

Номер: US20130190272A1

Автор: Kiguchi So, Tanaka Soichi

Принадлежит: Sumitomo Chemical Company, Limited

The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more pyrethroid compound(s) selected from Group (A) shows an excellent controlling activity on a pest. Group (A): a group consisting of acrinathrin, bifenthrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lamda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, deltamethrin, etofenprox, fenpropathrin, fenvalerate, esfenvalerate, flucythrinate, fluvalinate, tau-fluvalinate, halfenprox, permethrin, protrifenbute, silafluofen, tefluthrin and tralomethrin 2. The pest controlling composition according to claim 1 , wherein the weight ratio of the compound represented by Formula (1) to the pyrethroid compound(s) is from 0.0125/1 to 500/1.3. The pest controlling composition according to or claim 1 , wherein the compound represented by Formula (1) has R-absolute configuration.5. The method according to claim 4 , wherein the compound of Formula (1) and the pyrethroid compound(s) are applied to a seed.6. The method according to or claim 4 , wherein the weight ratio of the compound represented by Formula (1) to the'pyrethroid compound(s) is from 0.0125/1 to 500/1.7. The method according to claim 4 , wherein the compound represented by Formula (1) has R-absolute configuration. The present invention relates to a pest controlling composition and a method for controlling a pest.Hitherto, there has been provided compounds as an active ingredient for a composition for controlling a pest (see e.g., The Pesticide Manual—15th edition (BCPC published) ISBN 1901396188; and SHIBUYA INDEX (Index of Pesticides) 13th Edition 2008 (SHIBUYA INDEX RESEARCH GROUP published) ISBN 9784881371435).Also there has been provided a compound of Formula (1):(see e.g., WO 95/27693 pamphlet and WO 02/10101 pamphlet).An object of the present invention is ...

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Номер записи: 52

01-08-2013 дата публикации

Novel Benzyl Sulfonamide Derivatives Useful As MOGAT-2 Inhibitors

Номер: US20130197039A1

Автор: Fernandez Maria Carmen, Gonzalez-Garcia Maria Rosario, Pfeifer Lance Allen

Принадлежит: ELI LILLY AND COMPANY

The present invention provides compounds of Formula below: 2. A compound according to wherein R1 is —CH.3. A compound according to wherein R1 is —CF.4. A compound according to claim 1 , wherein R2 is selected from: H claim 1 , —CH claim 1 , —CHOCH.5. A compound according to wherein R2 is H.6. A compound according to wherein R3 is selected from: H claim 1 , —CH claim 1 , —CHOCH claim 1 , and —CHOCHCH.7. A compound according to wherein R3 is selected from: H claim 6 , —CHOCH claim 6 , and —CHOCHCH.8. A compound according to wherein R3 is —CHOCH.9. A compound according to wherein R4 is selected from: H and F.10. A compound according to wherein R4 is F.11. A compound according to wherein R5 is H.12. A compound according to wherein A is selected from CH or CF.13. A compound according to wherein A is N.14. A compound according to wherein X is CF or N.15. A compound according to wherein X is CH.16. A compound of according to wherein the pharmaceutically acceptable salt is a hydrogen chloride addition salt.17. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and at least one of a pharmaceutically acceptable carrier claim 1 , diluent claim 1 , or excipient.19. A compound which is N-[(1S)-2 claim 1 ,2 claim 1 ,2-Trifluoro-1-{4-[({(2S)-2-[(5-fluoropyridin-2-yl)oxy]-3-methoxypropyl}amino)methyl]phenyl}ethyl]methanesulfonamide hydrochloride.20. A pharmaceutical composition comprising N-[(1S)-2 claim 1 ,2 claim 1 ,2-Trifluoro-1-{4-[({(2S)-2-[(5-fluoropyridin-2-yl)oxy]-3-ethoxypropyl}amino)methyl]phenyl}ethyl]methanesulfonamide claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and at least one of a pharmaceutically acceptable carrier claim 1 , diluent claim 1 , or excipient.21. A compound which is N-[(1S)-2 claim 1 ,2 claim 1 ,2-Trifluoro-1-{4-[({(2S)-2-[(5-fluoropyridin-2-yl)oxy]-3-ethoxypropyl}amino)methyl]phenyl}ethyl]methanesulfonamide hydrochloride salt in crystalline form ...

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Номер записи: 53

01-08-2013 дата публикации

PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION COMPRISING AN APOLIPOPROTEIN PEPTIDE/PHOSPHOLIPID COMPLEX

Номер: US20130197226A1

Автор: Busseuil David, RHÉAUME Eric, TARDIF Jean-Claude

Принадлежит:

The present invention features pharmaceutical compositions and methods of using the pharmaceutical compositions for treating left ventricular diastolic dysfunction. In particular, the pharmaceutical compositions include an apolipoprotein complex comprising a lipid fraction and a protein fraction. 137-. (canceled)38. A pharmaceutical composition comprising Dalcetrapib (Propanethioic acid , 2-methyl- , S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl]ester) for the treatment of LVDD.39. A pharmaceutical composition for the treatment of LVDD comprising a compound selected from the group consisting of:S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]2,2-dimethylthiopropionate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]2-acetylamino-3-phenylthiopropionate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]3-pyridinethiocarboxylate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]chlorothioacetate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]methoxythioacetate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]thiopropionate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]phenoxy-thioacetate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]2-methylthiopropionate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]-4-chlorophenoxythioacetate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]cyclopropanethiocarboxylate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]2-acetylamino-4-carbamoylthiobutyrate;S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl]2-hydroxy-2-methylthiopropionate;S-[2-(1-isopentylcyclopentanecarbonylamino)phenyl]2,2-dimethylthiopropionate;S-[2-(1-isopentylcyclopentanecarbonylamino)phenyl]thioacetate;S-[4,5-dichloro-2-(1-isopentylcyclohexanecarbonylamino)-phenyl]2,2-dimethylthiopropionate;S-[4,5-dichloro-2-(1-isopentylcyclopentanecarbonylamino)-phenyl]2,2-dimethylthiopropionate;S-[2-(1-isopentylcyclohexanecarbonylamino)-4-trifluoromethylphenyl]2,2-dimethylthiopropionate;O-methyl S-[2-(1-isopentylcyclohexanecarbonylamino)phenyl ...

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Номер записи: 54

08-08-2013 дата публикации

COMPOUNDS FOR THE TREATMENT OF ADDICTION

Номер: US20130203704A1

Автор: Cannizzaro Carina E., Graupe Michael, Guerrero Juan A., Lu Yafan, Strickley Robert G., Venkataramani Chandrasekar, Zablocki Jeff

Принадлежит: Gilead Sciences, Inc.

Disclosed are novel compounds having the structure of Formula (I): 2. The compound of claim 1 , wherein Ris hydrogen.3. The compound of claim 1 , wherein Ris Calkyl.4. The compound of claim 1 , wherein Ris methyl.5. The compound of claim 1 , wherein Ris —CHOP(O)(OR)(OR); and each of Rand Ris independently Na claim 1 , Li claim 1 , K claim 1 , or hydrogen.6. The compound of claim 1 , wherein Ris hydrogen claim 1 , Calkyl claim 1 , or halo.7. The compound of claim 1 , wherein Ris methyl claim 1 , fluoro or chloro.8. The compound of claim 1 , wherein each of R claim 1 , R claim 1 , R claim 1 , and Ris independently hydrogen claim 1 , Calkyl claim 1 , or halo.9. The compound of claim 1 , wherein one of R claim 1 , R claim 1 , R claim 1 , or Ris methyl or fluoro.10. The compound of claim 1 , wherein Ris hydrogen or methyl.11. The compound of claim 1 , wherein at least one of Rand Ris not hydrogen.12. The compound of claim 1 , wherein at least one of Rand Ris halo or Calkyl.13. The compound of claim 1 , wherein each of Rand Ris independently chloro or methyl.14. The compound of claim 1 , wherein each of Rand Ris independently hydrogen claim 1 , chloro claim 1 , fluoro claim 1 , or methyl.15. The compound of claim 1 , wherein R claim 1 , Rand Rare each hydrogen.16. The compound of claim 1 , wherein Ris —O—(Cto C-alkyl)-O—(Cto C-alkyl).17. The compound of claim 1 , wherein Ris —OCHCHOCH.18. The compound of claim 1 , wherein:{'sup': 1', '20', '21, 'sub': '2', 'Ris hydrogen, methyl, or —CHOP(O)(OR)(OR);'}{'sup': '2', 'Ris hydrogen, methyl, or fluoro;'}{'sup': 3', '4, 'each of Ror Ris independently hydrogen or methyl;'}{'sup': 5', '6, 'each of Rand Ris independently hydrogen or fluoro;'}{'sup': '7', 'Ris hydrogen;'}{'sup': '9', 'Ris hydrogen, chloro, fluoro, or methyl;'}{'sup': '10', 'Ris hydrogen or fluoro;'}{'sup': '11', 'sub': 2', '2', '3, 'Ris hydrogen or —OCHCHOCH;'}{'sup': '12', 'Ris hydrogen or fluoro;'}{'sup': '13', 'Ris hydrogen, chloro, fluoro, or methyl; and'}{'sup ...

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Номер записи: 55

08-08-2013 дата публикации

PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE

Номер: US20130203816A1

Автор: Boyer Angelique Sun, Evdokimov Artem G., Greis Kenneth D., Kawamoto Richard Masaru, Warshakoon Namal C., Wu Shengde

Принадлежит: Akebia Therapeutics Inc.

The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. 132-. (canceled)34. A pharmaceutical composition comprising:{'claim-ref': {'@idref': 'CLM-00033', 'claim 33'}, 'A) the compound according to ; and'}B) one or more pharmaceutically acceptable excipients.35. A method for treating anemia comprising administering to a human or mammal in need of treatment and effective amount of the compound according to .37. A pharmaceutical composition comprising:{'claim-ref': {'@idref': 'CLM-00036', 'claim 36'}, 'A) the compound according to ; and'}B) one or more pharmaceutically acceptable excipients.38. A method for promoting wound healing comprising administering to a human or mammal in need of treatment and effective amount of the compound according to .40. The compound according to claim 39 , chosen from:{[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester;{[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester;5-(3-Chlorophenyl)-N-(2-amino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide;5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide;5-(3-Chlorophenyl)-N-(2-dimethylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide;{[5-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester;{[5-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester;5-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-N-(2-amino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide;5-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-N-(2-methylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide; and5-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-N-(2-dimethylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide.41. A pharmaceutical composition comprising:{'claim-ref': {'@idref': 'CLM- ...

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Номер записи: 56

15-08-2013 дата публикации

PESTICIDAL MIXTURES INCLUDING ISOXAZOLINE DERIVATIVES

Номер: US20130210623A1

Автор: Cassayre Jerome Yves, Molitor Elvira

Принадлежит: SYNGENTA CROP PROTECTION LLC

The present invention provides pesticidal mixtures comprising a component A and a component B, wherein component A is an enantiomeric mixture of a compound of formula I that is enantiomerically enriched for the S enantiomer (Formula I) wherein the symbol * indicates the chiral centre; wherein A, A, R, R, R, R, Rand p are as defined in claim , and component B is a compound as defined in claim . The present invention also relates to methods of using said mixtures for the control of plant pests. 5. A pesticidal mixture according to claim 1 , wherein component A is at least 80% enantiomerically enriched for the S enantiomer.6. A pesticidal mixture according to claim 1 , wherein component A is at least 90% enantiomerically enriched for the S enantiomer.7. A pesticidal mixture according to claim 1 , wherein component B is a compound selected froma macrolide compound including those selected from the group consisting of abamectin, emamectin (e.g. emamectin benzoate), ivermectin, milbemycin, spinosad, azadirachtin and spinetoram;a neonicotinoid compound including those selected from the group consisting of imidacloprid, thiacloprid, acetamiprid, nitenpyram, dinotefuran, thiamethoxam, clothianidin, nithiazine and flonicamid;a pyrethroid compound including those selected from the group consisting of permethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, bifenthrin, fenpropathrin, cyfluthrin, tefluthrin, ethofenprox, natural pyrethrin, tetramethrin, S-bioallethrin, fenfluthrin, prallethrin and 5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropane carboxylate; anda tetramic acid compound including those selected from the group consisting of spirotetramat and spirodiclofen.8. A pesticidal mixture according to claim 1 , wherein component B is a compound selected from the group consisting of abamectin claim 1 , lambda cyhalothrin claim 1 , spirotetramat claim 1 , and ...

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Номер записи: 57

15-08-2013 дата публикации

SYNERGISTIC INSECTICIDAL MIXTURES

Номер: US20130210863A1

Автор: Dotan Assaf, LEVI-RUSO Ganit

Принадлежит: MAKHTESHIM CHEMICAL WORKS, LTD.

The present invention relates to synergistic insecticidal mixtures comprising a) a Pyrethroid insecticide (preferably bifenthrin), b) a Neonicotinoid insecticide (preferably imidacloprid) and c) a Benzoylphenyl urea insecticide (preferably novaluron) and to the related compositions and methods of controlling insects. 1. A ternary insecticidal composition comprising , as active components a) a pyrethroid compound , b) a neonicotinoid compound and c) a benzoylphenylurea compound in a synergistically effective amount.2. The composition of claim 1 , wherein said pyrethroid compound is allethrin claim 1 , bifenthrin claim 1 , cyfluthrin claim 1 , beta-cyfluthrin claim 1 , cyhalothrin claim 1 , cyphenothrin claim 1 , cypermethrin claim 1 , alpha-cypermethrin claim 1 , beta-cypermethrin claim 1 , zeta-cypermethrin claim 1 , deltamethrin claim 1 , esfenvalerate claim 1 , etofenprox claim 1 , fenpropathrin claim 1 , fenvalerate claim 1 , imiprothrin claim 1 , lambda-cyhalothrin claim 1 , permethrin claim 1 , prallethrin claim 1 , pyrethrin I and II claim 1 , resmethrin claim 1 , silafluofen claim 1 , tau-fluvalinate claim 1 , tefluthrin claim 1 , tetramethrin claim 1 , tralomethrin claim 1 , transfluthrin or a combination comprising at least one of the foregoing.3. The composition of claim 2 , wherein said pyrethroid compound is bifenthrin.4. The composition of claim 1 , wherein said neonicotinoid compound is selected from acetamiprid claim 1 , clothianidin claim 1 , imidacloprid claim 1 , nitenpyram claim 1 , thiacloprid claim 1 , thiamethoxam or a combination comprising at least one of the foregoing.5. The composition of claim 4 , wherein said neonicotinoid compound is imidacloprid.6. The composition of claim 1 , wherein said benzoylphenylurea compound is selected from bistrifluoron claim 1 , chlorfluazuron claim 1 , diflubenzuron claim 1 , flucycloxuron claim 1 , flufenoxuron claim 1 , hexaflumaron claim 1 , lufenuron claim 1 , novaluron claim 1 , noviflumuron claim 1 , ...

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Номер записи: 58

15-08-2013 дата публикации

WOOD PRESERVATIVE FORMULATIONS COMPRISING ISOTHIAZOLONES WHICH PROVIDE PROTECTION AGAINST SURFACE STAINING

Номер: US20130210873A1

Автор: Hughes Andrew Stewart, Mason Lee, Warburton Paul Stuart

Принадлежит: Arch Timber Protection Limited

The present invention provides a wood preservative formulation comprising an isothiazolone, an organic fungicidal timber decay preservative and an unsaturated carboxylic or sulphonic acid, salt or precursor thereof. The formulations of the invention are surprisingly effective at protecting wood and other cellulosic substrates, in particular at providing prolonged protection against in-service surface staining. The invention also provides methods for treating wood and other cellulosic substrates with said formulations. 1. A wood preservative formulation comprising an isothiazolone , an organic fungicidal timber decay preservative and an unsaturated carboxylic or sulphonic acid , salt or precursor thereof.2. The formulation as defined in claim 1 , wherein the unsaturated carboxylic or sulphonic acid claim 1 , salt or precursor thereof is an unsaturated carboxylic or sulphonic acid or alkali metal salt thereof.3. The formulation as defined in claim 1 , wherein the unsaturated carboxylic or sulphonic acid claim 1 , salt or precursor thereof is an unsaturated cyclic carboxylic or sulphonic acid claim 1 , salt or precursor thereof.4. The formulation as defined in claim 3 , wherein the unsaturated carboxylic or sulphonic acid claim 3 , salt or precursor thereof is an aromatic acid claim 3 , salt or precursor thereof.6. The formulation as defined in claim 5 , wherein the aromatic acid or salt thereof is selected from the group consisting of benzoic acid and sodium benzoate.7. The formulation as defined in claim 3 , wherein the cyclic carboxylic or sulphonic acid is a resin acid or salt thereof.8. The formulation as defined in claim 7 , wherein the resin acid or salt thereof is selected from the group consisting of abietic acid claim 7 , sodium abietate claim 7 , pimaric acid and sodium pimarate.9. The formulation as defined in claim 1 , wherein the unsaturated carboxylic or sulphonic acid claim 1 , salt or precursor thereof is a linear unsaturated carboxylic acid claim 1 , ...

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Номер записи: 59

15-08-2013 дата публикации

MACROCYCLIC MODULATORS OF THE GHRELIN RECEPTOR

Номер: US20130211045A1

Автор: Marsault Éric, St-Louis Carl

Принадлежит: TRANZYME PHARMA INC.

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders. 2. The pharmaceutically acceptable salt of claim 1 , wherein the salt is an amorphous form.3. The pharmaceutically acceptable salt of claim 1 , wherein the salt is a crystalline form.4. The pharmaceutically acceptable salt of claim 1 , wherein the salt is a hydrochloride claim 1 , hydrobromide or hydroiodide salt.5. The pharmaceutically acceptable salt of claim 1 , wherein the salt is the hydrochloride salt.7. The process of further comprising:(a) dissolving the precipitated salt from (d) in a hot mixture of an alcohol and water to form solution C;(b) cooling solution C; and(c) separating a precipitated salt from solution C.8. The process of claim 6 , wherein the alcohol is ethanol.9. The process of claim 6 , wherein the acid is hydrochloric acid.10. The process of claim 6 , wherein the precipitated salt is an amorphous form.11. The process of claim 6 , wherein the precipitated salt is the hydrochloride salt.12. The process of claim 7 , wherein the alcohol is ethanol.13. The process of claim 7 , wherein the precipitated salt is a crystalline form.14. The process of claim 7 , wherein the precipitated salt is the hydrochloride salt.15. A pharmaceutical composition comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) a ...

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Номер записи: 60

29-08-2013 дата публикации

PESTICIDAL COMPOSITIONS

Номер: US20130225411A1

Автор: Buchholz Anke, Reiner Werner

Принадлежит: SYNGENTA CROP PROTECTION LLC

A pesticidal composition comprising (a) a pesticidal effective amount of at least one compound of formula I in which Q is i or ii or iii or an agrochemically acceptable salt or an N-oxide thereof, and (b) a plant growth regulator, where the ratio of compound of formula I to plant growth regulator is from 20:1 to 1:25. 2. A composition according to claim 1 , wherein the plant growth regulator is selected from antiauxins claim 1 , auxins claim 1 , cytokinins claim 1 , defoliants claim 1 , ethylene inhibitors claim 1 , growth inhibitors claim 1 , growth retardants claim 1 , growth stimulators claim 1 , unclassified plant regulators claim 1 , plant activators claim 1 , salicylates claim 1 , jasmonates claim 1 , cis-jasmonates claim 1 , plant peptide hormones claim 1 , polyamines; strigolactones and nitric oxide donors.3. A composition according to claim 1 , wherein the plant growth regulator is selected from trinexapac ethyl claim 1 , 1-methylcyclopropene claim 1 , ethephon claim 1 , chlormequat and acibenzolar-5-methyl.4. A composition according to claim 3 , wherein the plant growth regulator is selected from trinexapac ethyl claim 3 , 1-methylcyclopropene claim 3 , chlormequat and acibenzolar-5-methyl.5. A composition according to claim 1 , wherein the ratio compound of formula I to plant growth regulator is from 1:1 to 1:20.6. A method of combating and controlling pests which comprises treating the pests or the locus of the pests or the plant susceptible to attack by a pest with an insecticidally claim 1 , nematicidally or mollusicidally effective amount of a composition according to . The present invention relates to new pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.The present invention relates to a pesticidal composition comprising(a) a pesticidal effective amount of at least one compound of formula Iin which ...

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Номер записи: 61

29-08-2013 дата публикации

New Process for the Preparation of Aryl Substituted Olefinic Amines

Номер: US20130225827A1

Автор: Dull Gary Maurice, Genus John, Hellstrom Janna, Ratilainen Tommi, Ryberg Per Olof, Wahlstrom Niklas, Wannman Thomas

Принадлежит:

An improved process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine and (2S)-(4E)-N-methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine and new intermediates used in said process. 112-. (canceled)13. A process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine comprising:a1) mixing (2S)—N-(tert-butoxycarbonyl)-N-methyl-4-penten-2-amine (1 mole-equivalent) and a 5-bromo-3-alkoxypyridine (1.1 mole-equivalents) with a palladium source (0.01 mole-equivalents), a phosphine ligand (0.24 mole-equivalents) and a base (1.5 mole-equivalents) in a suitable organic solvent under an atmosphere of nitrogen; ora2) mixing N-methyl-4-penten-2-amine di-benzoyl-L-(−)-tartaric acid (1 mole-equivalent) and a 5-bromo-3-alkoxypyridine (1.1 mole-equivalents) with a palladium source (0.01 mole-equivalents), a phosphine ligand (0.24 mole-equivalents) and a base (1.5 mole-equivalents) in a suitable organic solvent under an atmosphere of nitrogen;b) adding water and heating the mixture to 90° C. for 15 to 25 h or until the appropriate level of conversion has been achieved;c) cooling the mixture and adding water and an acid, followed by stirring at 0-70° C. for 3 to 8 h;d) separating the organic solvent and the acidic aqueous phase followed by washing the aqueous phase with an organic solvent;e) adjusting the pH in the aqueous phase by the addition of a base, andf) extracting the product into the organic phase followed by separation of the organic phase; and optionallyg) treating the organic phase with a metal scavenger or charcoal to yield a (2S)-(4E)-N-methyl-5-[3-(5-alkoxypyridin)yl]-4-penten-2-amine;wherein:the aforesaid (2S)—N-(tert-butoxycarbonyl)-N-methyl-4-penten-2-amine of step a1) is prepared as follows:h) preparing 4-penten-2-ol by a process comprising:adding vinylmagnesium chloride to a mixture of copper(I) chloride and ...

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Номер записи: 62

05-09-2013 дата публикации

Use of active ingredients for controlling nematodes in nematode-resistant crops

Номер: US20130232645A1

Автор: Bill Striegel, Candace Poutre, Kevin Bugg, Nalini Desai, Steven Riniker, Wolfram Andersch

Принадлежит: Bayer Intellectual Property GmbH

The present invention relates generally to the use of fluopyram and compositions comprising fluopyram for controlling nematodes in nematode resistant crops and/or increasing crop yield and to methods particularly useful for controlling nematodes and/or increasing crop yield in those crops.

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Номер записи: 63

19-09-2013 дата публикации

METHODS OF TREATING SKIN DISORDERS WITH CAFFEIC ACID ANALOGS

Номер: US20130244986A1

Автор: Conrad Charles, Madden Timothy, Priebe Waldemar

Принадлежит: Moleculin LLC

Embodiments of the invention generally relate to pharmaceutical compositions containing at least one caffeic acid compound and methods for the topical treatment of proliferative and inflammatory skin disorders such as plaque psoriasis, atopic dermatitis, and other disorders. In some embodiments, the topical treatment includes applications of the pharmaceutical composition containing at least one caffeic acid compound or a mixture of caffeic acid compounds such as caffeic acid ester compounds, caffeic acid amide compounds, analogues thereof, derivatives thereof, salts thereof, or mixtures thereof. The pharmaceutical composition or topical dosage may contain the caffeic acid compound at a concentration by weight within a range from about 0.01% to about 20%, preferably, from about 0.1% to about 15%, preferably, from about 1% to about 10%, more preferably, from about 3% to about 7%, and more preferably, from about 4% to about 6%. 2. The method of , wherein the topical pharmaceutical composition comprises the compound of at a concentration by weight within a range from about 1% to about 10%.3. The method of , wherein the topical pharmaceutical composition comprises the compound of at a concentration by weight within a range from about 3% to about 7%.7. The method of claim 1 , wherein the topical pharmaceutical composition further comprises at least one additional agent selected from the group consisting of cell differentiating agents claim 1 , anti-proliferative agents claim 1 , mitochondrial inhibitors claim 1 , topical steroids claim 1 , immunosuppressive compounds claim 1 , JAK2 inhibitors claim 1 , JAK3 inhibitors claim 1 , parathyroid hormone-related protein (PTHrP) agonists claim 1 , cell adhesion blockers claim 1 , and combinations thereof.8. The method of claim 1 , wherein the topical pharmaceutical composition further comprises a cell differentiating agent selected from the group consisting of retinoic acid claim 1 , retinoic acid derivative claim 1 , vitamin D ...

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Номер записи: 64

19-09-2013 дата публикации

Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use

Номер: US20130245018A1

Автор: "Van t Hof Robert Jurgen", Clase Juha Andrew, Fisher Raymond, Greig Iain Robert, Sheridan Rose Mary, Smith Andrew, Tozer Matthew John, Tuffnell Andrew Robert

Принадлежит: PIMCO 2664 LIMITED

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. 1289-. (canceled)291. A compound according to claim 290 , wherein ═W— is —CH═ and —Y═ is —CH═.292. A compound according to claim 290 , wherein ═W— is —CH═ and —Y═ is —N═.293. A compound according to claim 291 , wherein -Dis cyclohexane-1 claim 291 ,4-di-yl.294. A compound according to claim 292 , wherein -Dis cyclohexane-1 claim 292 ,4-di-yl.295. A compound according to claim 291 , wherein -Dis 4-methyl-cyclohexane-1 claim 291 ,4-di-yl;296. A compound according to claim 292 , wherein -Dis 4-methyl-cyclohexane-1 claim 292 ,4-di-yl;297. A compound according to claim 293 , wherein —Ris —F; and —Ris —F.298. A compound according to claim 294 , wherein —Ris —F; and —Ris —F.299. A compound according to claim 295 , wherein —Ris —F; and —Ris —F.300. A compound according to claim 296 , wherein —Ris —F; and —Ris —F.301. A compound according to claim 293 , wherein —Ris —Cl; and ...

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Номер записи: 65

19-09-2013 дата публикации

PROCESS FOR CYCLOOXYGENASE-2 SELECTIVE INHIBITOR

Номер: US20130245272A1

Автор: Jariwala Viral Narendra, Mistry Ashokkumar Bhikhubhai, Shah Dharmesh Mahendra, Solanki Sanjay Amratlal, Vyas Ashok Vasantray

Принадлежит: Virdev Intermediates PVT. Ltd.

The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor. 2. The process according to claim 1 , wherein oxidation catalyst selected transition metal salts such as sodium molybdate claim 1 , sodium vanadate and sodium tungstate.3. The process according to claim 1 , wherein phase transfer catalyst selected from a group consisting of methyl-tri-n-octyl ammonium chloride claim 1 , methyl-tri-n-butyl ammonium chloride claim 1 , methyl-tri-n-butyl ammonium chloride claim 1 , benzethonium chloride claim 1 , and methyl benzethonium chloride.4. The process according to claim 1 , wherein the oxidation is carried out in presence of peroxide.5. The process according to claim 1 , wherein the process is conducted in biphasic system comprising of halogenated hydrocarbons and water.7. A process for preparation of 5-Chloro-3-(4-methylthio)phenyl-2-(2-methyl-5-pyridinyl)pyridine (IV) comprising reacting 1-(6-methyl-3-pyridinyl)-2[4-(methylthio)phenyl]ethanone (V) with 2-chloro-N claim 1 ,N-di methylamino trimethinium hexa fluoro phosphate (III) in presence of base followed by addition of alcohol and acid mixture claim 1 , adding an aqueous solution of ammonia followed by addition of ammonium salt claim 1 , heating claim 1 , to obtain 5-Chloro 3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine (IV).8. The process according to claim 7 , wherein claim 7 , base selected from sodium methoxide claim 7 , potassium methoxide claim 7 , potassium tert-butoxide claim 7 , ...

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Номер записи: 66

26-09-2013 дата публикации

COMPOUNDS

Номер: US20130252986A1

Автор: Hu Yimin, Jin Yun, Peng Cheng, WAN Zehong, WANG Jian, Zhang Xiaomin

Принадлежит:

The present invention relates to novel compounds that inhibit Lp-PLAactivity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA, for example atherosclerosis, Alzheimer's disease and/or diabetic macular edema. 2. The compound according to claim 1 , wherein A is N.3. The compound according to claim 1 , wherein n is 1 or 2.4. The compound according to claim 1 , wherein X is O.5. The compound according to claim 1 , wherein Y is O.6. The compound according to claim 1 , wherein z is —CH— heteroaryl claim 1 , wherein said heteroaryl is selected from the group consisting of pyridinyl claim 1 , pyrazole claim 1 , pynmidinyl claim 1 , and the heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of CHand —OCH.7. The compound according to claim 1 , wherein Ra is H.8. The compound according to claim 1 , wherein Rb is phenyl optionally substituted with one or more substituents independently selected from the group consisting of CN and F.9. The compound according to claim 1 , wherein Rc is phenyl optionally substituted with one or more substituents independently selected from the group consisting of F claim 1 , Cl claim 1 , CHor CF.10. The compound according to claim 1 , whereinA is n;n is 1 or 2;x is O;Y is O:{'sub': 2', '2', '3, 'Z is —CH-heteroaryl, wherein, said heteroaryl is selected from the group consisting of pyrodinyl, pyrazole, pyrimidyl, and the heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of CHand —OCH;'}Ra is H, F or Cl;Rb is phenyl optionally substituted with one or more substituents independently selected from the group consisting of CN and F; and{'sub': 3', '3, 'Rc is phenyl optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CHand CF.'}11. A pharmaceutical composition claim 1 ...

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Номер записи: 67

26-09-2013 дата публикации

SYNERGISTIC PARAFFINIC OIL AND BOSCALID FUNGICIDES

Номер: US20130253016A1

Автор: Fefer Michael, Liu Jun

Принадлежит: SUNCOR ENERGY INC.

Fungicidal compositions comprising a paraffinic oil and 2-chloro-N-(4′-chloro[1,1′-biphenyl]-2-yl)-3-pyridinecarboxamide (boscalid) are provided. The fungicidal compositions may further comprise a pigment. The fungicidal compositions may be provided as oil-in-water (O/W) emulsions which may be used for controlling fungal disease, such as dollar spot or bentgrass dead spot or bermudagrass dead spot, in plants, such as turfgrasses. Methods of applying the fungicidal compositions are also provided. 1. A fungicidal composition comprising an emulsifier , a paraffinic oil , and 2-chloro-N-(4′-chloro[1 ,1′-biphenyl]-2-yl)-3-pyridinecarboxamide (boscalid) , wherein the paraffinic oil and boscalid are present in amounts that are synergistically effective when applied to a plant for controlling a fungal pathogen of the plant.2. The composition according to claim 1 , wherein the paraffinic oil comprises a paraffin having a number of carbon atoms ranging from about 12 to about 50.3. The composition according to claim 1 , wherein the paraffinic oil comprises a paraffin having a number of carbon atoms ranging from about 16 to about 35.4. The composition according to claim 1 , wherein the paraffinic oil comprises a paraffin having an average number of carbon atoms of about 23.5. The composition according to claim 1 , wherein the paraffinic oil has a paraffin content of at least about 80%.6. The composition according to claim 1 , wherein the paraffinic oil has a paraffin content of at least about 90%.7. The composition according to claim 1 , wherein the paraffinic oil has a paraffin content of at least about 99%.8. The composition according to claim 1 , which further comprises a pigment and a silicone surfactant.9. The composition according to claim 8 , wherein the pigment is a polychlorinated (Cu II) phthalocyanine.10. The composition according to claim 8 , wherein the emulsifier comprises a natural or synthetic alcohol ethoxylate claim 8 , an alcohol alkoxylate claim 8 , an alkyl ...

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Номер записи: 68

26-09-2013 дата публикации

Use of Fluopyram for Controlling Nematodes in Crops and for Increasing Yield

Номер: US20130253018A1

Автор: Fuersch Helmut, Hellwege Elke, Hungenberg Heike, Rieck Heiko

Принадлежит: Bayer Intellectual Property GmbH

The present invention relates generally to the use of pyridylethylbenzamide derivatives for controlling nematodes and to methods particularly useful for controlling nematodes and/or increasing crop yield. 3. A composition comprisingA) fluopyram and/or an N-oxide thereof andB) at least one agrochemically active compound,at least one extender and/or surfactant, wherein said composition is capable of being used for controlling nematodes infesting at least one crop selected from the group consisting of vegetables, corn, soy, cotton, tobacco, coffee, sugarcane, fruits, tree crops, nuts, and flowers and/or capable of being used for increasing yield of said at least one crop.4. The composition according to claim 3 , wherein fluopyram and/or the N-oxide has been applied to said at least one crop at a rate of 100 g to 5 kg per ha.5. A method of controlling nematodes comprising applying fluopyram and/or an N-oxide thereof according to claim 1 , to a plant.6. A method of treating seeds for control of nematodes in a crop selected from the group consisting of vegetables claim 1 , potato claim 1 , corn claim 1 , soy claim 1 , cotton and banana claim 1 , comprising applying a compound according to to a seed.7. A method for increasing yield claim 1 , comprising applying fluopyram and/or an N-oxide thereof according to claim 1 , to a plant.8. A method for increasing yield claim 1 , comprising applying fluopyram and/or an N-oxide thereof according to to a seed. The present invention relates generally to the use of N-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-ethyl}-2,6-dichlorobenzamide (fluopyram) and compositions comprising fluopyram for controlling nematodes in vegetables, in particular tomato and cucurbits, potato, corn, soy, cotton, tobacco, coffee, fruits, in particular, citrus fruits, pine apples and bananas, and grapes and to methods particularly useful for controlling nematodes and/or increasing crop yield in consisting of vegetables, in particular tomato and cucurbits, ...

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Номер записи: 69

26-09-2013 дата публикации

Pesticidal composition containing lambda cyhalothrin and diafenthiuron.

Номер: US20130253054A1

Автор: Deepak Pranjivandas Shah

Принадлежит: Individual

The present invention relates to a composition comprising an effective amount of lambda cyhalothrin in the range of 0.5% to 12%; an effective amount of diafenthiuron in the range of 15% to 70% wherein the ratio of lambda cyhalothrin to diafenthiuron is in the range of 1:4 to 1:35; and at least one agrochemical excipient.

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Номер записи: 70

03-10-2013 дата публикации

Method for Mosquito Control

Номер: US20130259846A1

Автор: Dobson Stephen

Принадлежит:

A formulation and method for insect control is provided in the form of insecticide carrying insects which can be introduced in a population to thereby control the insect population. The formulation may include artificially generated adult insect carriers of a larvicide in which the larvicide has minimal impact on the adult insect and which larvicide affects juvenile survival or interferes with metamorphosis of juvenile insects to adulthood. The insects may be either male or female and may include mosquitoes. 1. A method for insect control , comprising:introducing insects which carry one or more insecticides comprising at least a larvicide, to an insect population, to thereby control the insect population.2. The method of claim 1 , wherein the insects are adult insects claim 1 , and the method further comprises exposing the adult insects to a pesticide which affects juvenile survival or interferes with metamorphosis of juvenile insects to adulthood claim 1 , and which pesticide has little impact on adult insects.3. The method of claim 2 , wherein the adult insects are male insects.4. The method of claim 1 , wherein the insect population is a mosquito population.5. The method of claim 2 , wherein the insect population is a mosquito population.6. The method of claim 3 , wherein the insect population is a mosquito population.7. The method of claim 6 , wherein the adult male insects are mosquitoes.8. The method of claim 2 , wherein the pesticide is a chemical agent.9. The method of claim 8 , wherein the chemical agent is selected from the group consisting of Azadirachtin claim 8 , Diflubenzuron claim 8 , Methoprene claim 8 , Neem Oil (Azadirachta indica) claim 8 , Novaluron claim 8 , Pyriproxyfen claim 8 , S-Methoprene claim 8 , S-Hydropene and Temephos.10. The method of claim 2 , wherein the pesticide is a biological agent.11AscogregarineBacillus sphaericus, Bacillus thuringiensis israelensis,CopepodaDensovirinaeLagenidium giganteum, MicrosporidaSpinosadSpinosyn.. The ...

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Номер записи: 71

03-10-2013 дата публикации

PESTICIDAL MIXTURES COMPRISING ISOXAZOLINE DERIVATIVES

Номер: US20130261069A1

Автор: Cassayre Jerome Yves, Dutton Ana, Haas Ulrich Johannes

Принадлежит: SYNGENTA CROP PROTECTION LLC

The present invention provides pesticidal mixtures comprising a component A, a component B and a component C, wherein component A is a compound of formula (I) wherein one of Yand Yis S, SO or SOand the other is CH; L is a direct bond or methylene; Aand Aare C—H, or one of Aand Ais C—H and the other is N; Ris hydrogen or methyl; Ris chlorodifluoromethyl or trifluoromethyl; Ris 3,5-dibromo-phenyl, 3,5-dichloro-phenyl, 3,4-dichloro-phenyl, or 3,4,5-trichloro-phenyl; Ris methyl; Ris hydrogen; or Rand Rtogether form a bridging 1,3-butadiene group; component B is a compound selected from Sedaxane, Fludioxonil, Metalaxyl, Mefenoxam, Cyprodinil, Azoxystrobin, Tebuconazole, Difenoconazole, Thiabendazole, Fluopyram, Penflufen, N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide and Fuxapyroxad; or component B is a compound selected from Tefluthrin, Lambda-cyhalothrin, Abamectin, Spinosad, Spinetoram, Chlorpyrifos, Thiodicarb, Chlorantraniliprole, Cyantraniliprole, spp. such as and , Imidacloprid, Thiacloprid, Acetamiprid, Nitenpyram, Dinotefuran, Thiamethoxam, Clothianidin, Nithiazine, Flonicamid, Fipronil, Pyrifluquinazone, Pymetrozine, Sulfoxaflor and Spirotetramat; and component C is a compound selected from an insecticide, a fungicide and a nematicide, which insecticide is selected from neonicotinoids, carbamates, diamides, spinosyns, phenylpyrazoles, pyrethroids, Pyrifluquinazone, Pymetrozine, Sulfoxaflor and Spirotetramat; which fungicide is selected from Azoxystrobin, Trifloxystrobin, Fluoxastrobin, Cyproconazole, Difenoconazole, Prothioconazole, Tebuconazole, Triticonazole, Fludioxonil, Thiabendazole, Ipconazole, Cyprodinil, Myclobutanil, Metalaxyl, Mefenoxam, Sedaxane, N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, Fluopyram, Penflufen, Fuxapyroxad, Fluopyram, and Penthiopyrad; which nematicide is selected from ...

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Номер записи: 72

03-10-2013 дата публикации

ADJUVANTS FOR INSECTICIDES

Номер: US20130261083A1

Автор: Hazen James Lyle, Sun Jinxia Susan

Принадлежит: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.

The invention relates to additives enhancing the activity of certain insecticides, to significantly increase the effect of such insecticides when applied to the exterior foliage of a plant, thus increasing the kill rate of feeding insects that are normally protected deep within other tissue structures of the plant. 5. The composition of claim 1 , wherein p:q is between 50:50 and 20:80.6. The composition of claim 1 , wherein p:q is between 56:44 and 29:71.7. The composition of claim 1 , wherein p is 5.0 to 9.5 and q is 12.0 to 7.5.8. The composition of claim 1 , wherein p is 5.0 and q is 12.0.9. The composition of claim 1 , wherein R is the hydrocarbon group of tallow amine.10. The composition of comprising at least one insecticidally active compound being a nicotinoid.11. The composition according to comprising at least one insecticidally active compound selected from the group consisting of chlofenapyr claim 1 , pyrethrin claim 1 , piperonyl butoxide and any mixture of two or more thereof.12. A method for controlling insect populations of crops claim 1 , said insect populations located within tissue structures of said crops claim 1 , the method comprises applying to the exterior foliage of said crops the insecticide composition of .1315.-. (canceled)16. The composition of wherein the nicotinoid is selected from the group consisting of clothianidin claim 10 , imidacloprid claim 10 , and thiamethoxam. The invention relates to additives enhancing the activity of certain insecticides, to significantly increase the effect of such insecticides when applied to the exterior foliage of a plant, thus increasing the kill rate of feeding insects that are normally protected deep within other tissue structures of the plant.The adjuvant industry have until now been focused on the enhancement of herbicidal activity. For example, in U.S. Pat. No. 5,226,943 certain adjuvants were disclosed for use with herbicides. Such adjuvants have the ability to cause changes in the plant ...

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Номер записи: 73

03-10-2013 дата публикации

METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES

Номер: US20130261310A1

Автор: BLAND DOUGLAS C., DAVIS CLARK S., FUNG ALEXANDER P., JR. Ronald, RENGA JAMES, Ross, Roth Gary A.

Принадлежит:

3-substituted-6-trifluoromethyl pyridines are useful synthetic intermediates in the preparation of the N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines, which are useful in forming potent insecticides. Methods of forming such 3-substituted-6-trifluoromethyl pyridines are disclosed. Also disclosed are methods of using 6-trichloromethyl halogenated pyridines to form 3-substituted-6-trifluoromethyl pyridines are disclosed. 1. A method of forming a 3-substituted-6-trifluoromethyl pyridine , the method comprising reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine.2. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 6-trichloromethyl-2 claim 1 ,3-dihalo pyridine with a fluorinating agent to form a 6-trifluoromethyl-2 claim 1 ,3-dihalo pyridine.3. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 2 claim 1 ,3-dichloro-6-trichloromethyl pyridine with a fluorinating agent to form a 2 claim 1 ,3-dichloro-6-trifluoromethyl pyridine.4. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 6-trichloromethyl halogenated pyridine with antimony pentafluoride to form a 6-trifluoromethyl halogenated pyridine.5. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6-trifluoromethyl halogenated pyridine comprises reacting a 6-trichloromethyl halogenated pyridine with hydrogen fluoride to form a 6-trifluoromethyl halogenated pyridine.6. The method of claim 1 , wherein reacting a 6-trichloromethyl halogenated pyridine with a fluorinating agent to form a 6- ...

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Номер записи: 74

17-10-2013 дата публикации

HERBICIDAL COMPOSITION AND METHOD OF USE THEREOF

Номер: US20130274105A1

Автор: DUNNE Cheryl Lynn, James John

Принадлежит:

The present invention relates to a herbicidal composition comprising topramezone and a pyridine herbicide. The invention also relates to methods of controlling the growth of weeds, and to the use of this composition. 1. A herbicidal composition comprising a herbicidally effective amount of a mixture of topramezone and a pyridine herbicide.2. The composition of claim 1 , wherein the pyridine herbicide is dithiopyr.34-. (canceled)5. The composition of claim 1 , wherein the weight ratio of topramezone to pyridine herbicide is between about 1:10 and about 10:1.6. The composition of claim 5 , wherein the weight ratio of topramezone to pyridine herbicide is between about 1:5 and about 5:1.7. The composition of claim 6 , wherein the weight ratio of topramezone to pyridine herbicide is between about 1:2 and about 2:1.8. A method for controlling or modifying the growth of white clover claim 1 , comprising applying to the locus of the white clover a herbicidally effective amount of a composition according to .9. The method of claim 8 , wherein the white clover is present in turfgrass.10. The method of claim 8 , wherein the composition is applied (i) pre-emergence or (ii) post-emergence.11. The method of claim 8 , wherein the combined amount of topramezone and pyridine herbicide applied to the locus of the weeds is between about 0.005 kg/ha and about 5 kg/ha.12. The method of claim 11 , wherein the combined amount of topramezone and pyridine herbicide applied to the locus of the weeds is between about 0.05 kg/ha and about 2 kg/ha.13. The method of claim 12 , wherein the combined amount of topramezone and pyridine herbicide applied to the locus of the weeds is between about 0.1 kg/ha and about 0.5 kg/ha.14. (canceled) The present invention relates to a herbicidal composition comprising mesotrione and a pyridine herbicide such as dithiopyr or thiazopyr. The invention also relates to a method of controlling the growth of weeds and to the use of this composition.The protection of ...

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Номер записи: 75

17-10-2013 дата публикации

METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS

Номер: US20130274272A1

Автор: Devadas Balekudru, Hockerman Susan L., Monahan Joseph B., Schindler John F., Selness Shaun R.

Принадлежит:

The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): 3. Compound according to claim 2 , which is a compound selected from the group consisting of:3-chloro-4-((2,4-difluoro-3-methylbenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;3-bromo-4-((2,4-difluoro-3-methylbenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;3-chloro-4-((2,4-difluoro-3-methylbenzyl)oxy)-6″-(2-hydroxypropan-2-yl)-5′,6-dimethyl-2H-[1,4′:2′,2″-terpyridin]-2-one;3-bromo-4-((2,4-difluoro-3-methylbenzyl)oxy)-6″-(2-hydroxypropan-2-yl)-5′,6-dimethyl-2H-[1,4′:2′,2″-terpyridin]-2-one;3-chloro-4-((2,4-difluoro-3-methylbenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;3-bromo-4-((2,4-difluoro-3-methylbenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one; and3-chloro-4-((2,4-difluoro-3-methylbenzyl)oxy)-6″-(2-hydroxypropan-2-yl)-3″,5′,6-trimethyl-2H-[1,4′:2′,2″-terpyridin]-2-one;3-bromo-4-((2,4-difluoro-3-methylbenzyl)oxy)-6″-(2-hydroxypropan-2-yl)-3″,5′,6-trimethyl-2H-[1,4′:2′,2″-terpyridin]-2-one.5. Compound according to claim 4 , which is a compound selected from the group consisting of:3-chloro-4-((2,4-difluoro-5-methylbenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;3-bromo-4-((2,4-difluoro-5-methylbenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;3-chloro-4-((2,4-difluoro-5-methylbenzyl)oxy)-6″-(2-hydroxypropan-2-yl)-5′,6-dimethyl-2H-[1,4′:2′,2″-terpyridin]-2-one;3-bromo-4-((2,4- ...

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Номер записи: 76

17-10-2013 дата публикации

POLYMORPHS OF SORAFENIB ACID ADDITION SALTS

Номер: US20130274478A1

Автор: Jaryal Jagdev Singh, Prasad Mohan, Sathyanarayana Swargam, Thaper Rajesh Kumar

Принадлежит: RANBAXY LABORATORIES LIMITED

The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them, and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib. 2. The crystalline sorafenib methane sulphonate of further characterized by X-ray diffraction peaks having d-spacing values at about 10.80 claim 1 , 5.85 claim 1 , 5.20 claim 1 , 4.58 claim 1 , and 4.41 Å.3. The crystalline sorafenib methane sulphonate of characterized by a DSC thermogram having endotherm at about 205.07° C.4101112. The crystalline sorafenib methane sulphonate of characterized by X-ray diffraction spectrum claim 1 , DSC thermogram claim 1 , TGA claim 1 , and IR spectrum as depicted in claim 1 , claim 1 , claim 1 , and claim 1 , respectively. This application is a divisional application of U.S. patent application Ser. No. 13/497,861 filed on May 9, 2012, the contents of which are incorporated herein in their entirety.The present invention provides amorphous and crystalline forms of sorafenib acid addition salts, a process for their preparation, pharmaceutical compositions comprising them, and their use for the treatment of cancer. The present invention also provides a process for the preparation of sorafenib acid addition salts.Sorafenib is an inhibitor of the enzyme RAF kinase known from WO 00/42012. It is chemically 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N-methylpyridine-2-carboxamide having the structure as represented by Formula I.Sorafenib is marketed in the United States as its tosylate salt of Formula II under the brand name Nexavar®.Several acid addition salts of sorafenib are disclosed in WO 00/42012.Processes for the preparation of sorafenib tosylate are disclosed in WO 2006/034796, WO 2006/034797, WO 2009/034308, WO 2009/054004, WO 2009/106825 and WO 2009/092070, which are incorporated herein by reference. Besides sorafenib tosylate, ...

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Номер записи: 77

24-10-2013 дата публикации

Dual Action Lethal Containers, Systems, Methods and Compositions for Killing Adult Mosquitos and Larvae

Номер: US20130276355A1

Автор: Koehler Philip G., Pereira Roberto M., Ragasa Ephraim V.

Принадлежит: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Dual action lethal containers, systems, methods, compositions and formulas used to kill mosquitoes and their larvae. The containers can have separate interior larvicidal and adulticidal coatings separated from each other by horizontal water line holes in the container. Another container can use a novel combined coating of a larvicidal and adulticidal coating. Unique compositions of adulticidal coatings, larvicidal coatings and combined adulticidal and larvicidal coatings can be used as liners. 1. A dual action container for killing insects and their larvae , comprising:a housing having a closed bottom and closed side walls and open top;a plurality of drain openings about the housing substantially midway between the closed bottom and open top;an adulticidal coating layer on an inner surface of the housing above the plurality of drain openings; anda larvicidal coating layer on an inner surface of the housing below the plurality of drain openings, wherein the adulticidal coating and the larvicidal coating kill both adult insects and their larvae over time.2. The dual action container of claim 1 , wherein the adulticidal coating includes:permethrin.3. The dual action container of claim 1 , wherein the larvicidal coating includes:pyriproxyfen.4. The dual action container of claim 1 , wherein the insects include mosquitoes.5. The dual action container of claim 1 , wherein at least one of the adulticidal coating and the larvicidal coating includes a mixture for a long lasting insecticide that does not break down.6. The dual action container of claim 1 , wherein at least one of the adulticidal coating and the larvicidal coating includes an additive for allowing a slow time release of an insecticide.7. The dual action container of claim 1 , wherein the adulticidal coating contains insecticide that kills adult mosquitoes as they land to lay eggs claim 1 , and the larvicidal coating that kills larval mosquitoes which emerge from the eggs.8. The dual action container of claim 1 ...

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Номер записи: 78

24-10-2013 дата публикации

SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS

Номер: US20130281293A1

Автор: Satchivi Norbert M., Schmitzer Paul R.

Принадлежит:

Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of AD67 (MON 4660), benoxacor, 2-CBSU, daimuron, dichlormid, dicyclonon (BAS 145 138H), fenchlorazole-ethyl, fenclorim, fluxofenim, furilazole (MON 13900), glyphosate, isoxadifen-ethyl, mefenpyr-diethyl, naphthalic anhydride, oxabetrinil and mixtures thereof. 2. The composition of in which the 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide is a 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylic acid derivative or a 4-amino-3-chloro-6-(2 claim 1 ,4-dichloro-3-methoxy-phenyl)-2-pyridinecarboxylic acid derivative.3. The composition of in which the weight ratio of the safener to 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide is between about 16:1 and about 1:32.5. The composition of claim 3 , wherein the weight ratio of the safener to 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylate herbicide is between about 16:1 and about 1:32.12Triticum aestivumHordeum vulgare.. The method of claim 4 , wherein the wheat and barley is or This application claims the benefit of U.S. Provisional Application Ser. No. 61/117,332 filed on Nov. 24, 2008. This invention concerns the safening of the herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in cereal crops.When agrochemicals, such as plant protection agents and especially herbicides, are used, the cultivated plants may be damaged to a certain degree, depending on factors such as the dose of agrochemicals and their method of application, the species of cultivated plant, the nature of the soil and climatic conditions, for example, length of time of exposure to light, temperature and amounts of precipitation. Thus, it is known that cultivated plants which are to be protected from the adverse effect of undesirable plant growth may be damaged to a certain degree when an effective dose of herbicide is used. ...

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Номер записи: 79

31-10-2013 дата публикации

Compositions And Methods For Preventing Or Reducing Resistance Of Insects To Insecticides

Номер: US20130287831A1

Автор: Graham David Moores, Robin Vera Gunning

Принадлежит: Department of Primary Industries (State of New South Wales), ROTHAMSTED RESEARCH LTD

A method for preventing or reducing resistance to a pesticide of a substrate pest, which method comprises the administration to the substrate or the pest of a composition comprising: (a) a rapid-release formulation of an inhibitor of a factor causing or contributing to the resistance of the pest to the pesticide; and, substantially simultaneously, (b) a non-rapid release formulation of the pesticide. The invention also provides compositions suitable for use in such a method.

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Номер записи: 80

07-11-2013 дата публикации

Agrochemical Formulation Comprising Encapsulated Pesticide

Номер: US20130295152A1

Автор: Bihlmeyer Daniel, Bork Thomas, Distler Juergen, Katz Britta, Nord Simon, Schroeder-Grimonpont Tina, Sikuljak Tatjana, Taranta Claude, Warriner Richard A., Wofford James Thomas

Принадлежит: BASF SE

The present invention relates to a aqueous composition containing a suspended pesticide A, and microcapsules comprising a shell and a core, wherein the core contains a pesticide B and an aprotic, polar solvent B, and the shell contains poly(meth)acrylate, which comprises C-Calkyl esters of acrylic and/or methacrylic acid, acrylic acid, methacrylic acid, and/or maleic acid in polymerized form. The invention further relates to a method for preparing said composition comprising the mixing of the pesticide A, water and the microcapsules, to said microcapsule, wherein the core contains the pesticide B and a solvent A, wherein the weight ratio of the pesticide B to the sum of all solvents in the core is from 1:1 to 1:10, and wherein the microcapsule contains up to 7 wt % poly(meth)acrylate, based on the total amount of all pesticides in the core, all solvents in the core, and the poly(meth)acrylate. 115-. (canceled)16. An aqueous composition containinga suspended pesticide A, andmicrocapsules comprising a shell and a core, wherein(a) the core contains a pesticide B and an aprotic, polar solvent B, and{'sub': 1', '24, '(b) the shell contains poly(meth)acrylate, which comprises C-Calkyl esters of acrylic or methacrylic acid, acrylic acid, methacrylic acid, or maleic acid in polymerized form.'}17. The composition according to claim 16 , wherein the pesticide B is present in dissolved form.18. The composition according to claim 16 , wherein the pesticide A has a solubility in water of less than 10 g/l at 20° C.19. The composition according to claim 16 , wherein the core further contains a water-immiscible solvent A.20. The composition according to claim 16 , wherein solvent A is a hydrocarbon.21. The composition according to claim 19 , wherein the weight ratio of solvent A to solvent B is in the range from 10:1 to 1:5.22. The composition according to claim 16 , wherein solvent B is a ketone.23. The composition according to claim 16 , wherein weight ratio of the sum of all ...

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Номер записи: 81

07-11-2013 дата публикации

CONTROL OF AAD DICOT VOLUNTEERS IN MONOCOT CROPS

Номер: US20130296170A1

Автор: Chambers Richard S., Hanger Gregory A., ROBINSON ANDREW E., Satchivi Norbert M., Wright Terry R.

Принадлежит: DOW AGROSCIENCES LLC

The subject invention relates in part to the control of AAD-12 and/or AAD-13 dicot volunteers in fields planted with monocot crops such as corn. The dicots can include soybeans and cotton. 1. A method of controlling AAD-12 dicot volunteer plants in a field comprising monocot plants , said volunteer plants comprising an AAD-12 gene that encodes an AAD-12 protein , wherein said method comprisesapplying a herbicide to said volunteer plants, wherein said herbicide is selected from the group consisting of dicamba, clopyralid, and a triazine.2. The method of claim 1 , wherein said volunteer plants are selected from the group consisting of soybeans and cotton.3. The method of claim 1 , wherein said monocot plants are corn plants.4. The method of claim 1 , wherein said dicot volunteer plants are soybean plants grown from seed comprising an event as available under ATCC deposit number PTA-10442.5. The method of claim 1 , wherein said triazine herbicide is atrazine.6. The method of claim 3 , wherein said dicot plants are soybeans.7. The method of claim 1 , wherein said monocot volunteer plant comprises a glyphosate- and/or a glufosinate-tolerance gene.8. A method of controlling AAD-12 volunteer soybean plants in a field comprising monocot plants claim 1 , wherein said volunteer plants are grown from seed comprising an event as available under ATCC deposit number PTA-10442 and/or comprising SEQ ID NO:1 claim 1 , wherein said method comprisesapplying a herbicide to said volunteer plants, wherein said volunteer plants are susceptible to said herbicide, and said monocot plants are tolerant to said herbicide.9. The method of claim 8 , wherein said monocot plants are corn plants.10. The method of claim 8 , wherein said volunteer plants further comprises a glyphosate-tolerance gene claim 8 , and said herbicide is glufosinate.11. The method of claim 8 , wherein said volunteer plants further comprises a glufosinate-tolerance gene claim 8 , and said herbicide is glyphosate. Corn ( ...

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Номер записи: 82

07-11-2013 дата публикации

USE OF PRO-FUNGICIDES OF UK-2A FOR CONTROL OF SOYBEAN RUST

Номер: US20130296372A1

Автор: CORREA DA SILVA Olavo, Davies Kent William, Oimette David George, Owen W. John

Принадлежит: DOW AGROSCIENCES LLC

The present disclosure is related to the field of agrochemicals, including profungicides of UK-2A and their use to control soybean rust. 3. The method of claim 1 , wherein the composition further includes at least one of one additional agriculturally active ingredient selected from the group consisting of: insecticide claim 1 , an herbicide claim 1 , and a fungicide.4. The method of claim 1 , wherein the plant pathogen is Asian soybean rust.5. The method of claim 2 , wherein the composition further includes at least one additional agriculturally active ingredient selected from the group consisting of an insecticide claim 2 , an herbicide claim 2 , and a fungicide.6. The method of claim 2 , wherein the plant pathogen is Asian soybean rust. This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/643,689 filed May 7, 2012, which is expressly incorporated herein by reference.Fungicides are compounds, of natural or synthetic origin, which act to protect and cure plants against damage caused by agriculturally-relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less.The present disclosure relates to profungicides of UK-2A and their use as fungicides. Profungicides of UK-2A may offer protection against ascomycetes, basidiomycetes, deuteromycetes and oomycetes.One embodiment of the present disclosure includes a method of controlling a pathogen-induced disease in a plant that is at risk of being diseased from the pathogen comprising contacting the plant or an area adjacent to the plant with a composition including profungicides of UK-2A.Another embodiment of the present disclosure is a use of profungicides of UK-2A for protection of a plant against attack by a phytopathogenic organism or the treatment of a plant infested by a phytopathogenic organism, comprising the application of profungicides of UK-2A, ...

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Номер записи: 83

14-11-2013 дата публикации

Pesticidal composition comprising sulphur, an insecticide and an agrochemical excipient

Номер: US20130302446A1

Автор: Deepak Pranjivandas Shah

Принадлежит: Individual

The present invention relates to an pesticidal composition comprising an effective amount of a sulphur; an effective amount of at least one insecticide selected from the group consisting of cartap fipronil, pirimicarb, buprofezine, thiachloprid, acetamiprid, clothianidin, diafenthiuron, novaluron, flubendiamide, spirotetramat, thiamethoxam, imidacloprid or salts thereof, and at least one agrochemically acceptable excipient.

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Номер записи: 84

14-11-2013 дата публикации

METHODS OF IMPROVING PLANT GROWTH

Номер: US20130303376A1

Автор: Ebbinghaus Dirk, Hungenberg Heike, JESCHKE Peter, Thielert Wolfgang, Urlass Claudia, Velten Robert

Принадлежит:

The invention relates to the use of at least one compound selected from the class of the enaminocarbonyl compounds for enhancing plants' intrinsic defences and/or for improving plant growth and/or for enhancing the resistance of plants to plant diseases which are caused by fungi, bacteria, viruses, MLOs (mycoplasma-like organisms) and/or RLOs (rickettsia-like organisms), and/or for enhancing the resistance of plants to abiotic stress factors. 2. The method according to claim 1 , wherein the at least one enaminocarbonyl compound is selected from the group consisting of(I-8), 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one(I-9), 4-{[(5,6-dichloropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one(I-10), 4-{[(5,6-dichloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one(I-11), 4-{[(6-bromo-5-fluoropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one(I-12), 4-{[(6-bromo-5-fluoropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one(I-13), 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one(I-14), 4-{[(5,6-dichloropyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one(I-15), 4-{[(5,6-dichloropyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one(I-16), 4-{[(6-bromo-5-fluoropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one and (I-17), 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one.3. The method according to claim 1 , wherein the plant treated with the at least one enaminocarbonyl compound is transgenic.4. The method according to claim 1 , wherein the plant is protected from biotic or abiotic stress factors by the treatment.5. The method according to claim 1 , wherein the at least one enaminocarbonyl compound is used in combination with at least one fertilizer.7. The method according to claim 6 , wherein a nutrient solution is used for the treatment of the seed and/or the germinating plant in which an amount of from 0.0005 to 0.025% by weight of at least one enaminocarbonyl compound based on ...

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Номер записи: 85

14-11-2013 дата публикации

Substituted 2-Aminoacetamides and the Use Thereof

Номер: US20130303568A1

Автор: CAI Sui Xiong, LAN Nancy C., Wang Yan

Принадлежит:

The invention is directed to substituted 2-aminoacetamides represented by formula (II): 2. The method according to claim 1 , wherein A1 and A2 are both optionally substituted aryl moieties.3. The method according to claim 1 , wherein{'sub': 1', '2', '2', '1-6', '1-4, 'Aand Aare phenyl moieties, that Ais optionally substituted by one or two substituents independently selected from the group consisting of hydrogen, Calkyl, halogen, hydroxy, Calkoxy or trifluoromethyl;'}{'sub': 1', '2, 'Rand Rare hydrogen;'}{'sub': 3', '4, 'Rand Rare methyl;'}{'sub': 5', '6', '7', '1-6', '3-7, 'R, Rand Rare independently hydrogen, Calkyl, or Ccycloalkyl; and'}{'sub': '2', 'X is O, S, CH, or NH.'}4. The method according to claim 1 , wherein said compound is selected from the group consisting of:2-(4-(2-fluorobenzyloxy)benzylamino)-2-methyl-propanamide;2-(4-(4-fluorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(3,4-methylenedioxyphenoxy)benzylamino)-2-methyl-propanamide;2-(4-(3,4-methylenedioxybenzyloxy)benzylamino)-2-methyl-propanamide;2-(4-cyclohexyloxybenzylamino)-2-methyl-propanamide;2-(4-(5,6,7,8-tetrahydro-2-naphthoxy)benzylamino)-2-methyl-propanamide;2-(4-(2-adamantanoxy)benzylamino)-2-methyl-propanamide;2-(4-(4-chloro-2-fluorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(2,4-difluorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(3,4-difluorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(6-bromo-4-fluorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(4-nitrophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(4-tetrahydropyranoxy)benzylamino)-2-methyl-propanamide;2-(4-(3,5-difluorophenoxy)benzylamino)-2-methyl-propanamide,2-(4-(4-chlorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(4-methylphenoxy)benzylamino)-2-methyl-propanamide;2-(4-(2-chloro-4-fluorophenoxy)benzylamino)-2-methyl-propanamide;2-(4-(5-indanoxy)benzylamino)-2-methyl-propanamide;2-(4-cycloheptoxybenzylamino)-2-methyl-propanamide;2-(4-(1-methyl-4-piperidinoxy)benzylamino)-2-methyl-propanamide;2-(4-(exo-2- ...

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Номер записи: 86

14-11-2013 дата публикации

PESTICIDAL COMPOSITION AND METHOD FOR CONTROLLING PESTS

Номер: US20130303610A1

Автор: Sasaki Takashi

Принадлежит: Sumitomo Chemical Company, Limited

The present invention relates to a pesticidal composition and a pest control method which have an excellent efficacy in controlling pests. The pesticidal composition comprises an ester compound of Formula (1): wherein Rand Rare each independently selected from the group consisting of hydrogen atom, methyl group, trifluoromethyl group and chlorine atom; and Ris hydrogen atom, methyl group or methoxymethyl group, a glycol ether, and water wherein the glycol ether content is from 10 wt % to 50 wt % and water is from 20 wt % to 85 wt % of the total amount of the composition. 2. The pesticidal composition of wherein the glycol ether is an ethylene glycol ether.3. The pesticidal composition of wherein the glycol ether is at least one compound selected from the group consisting of an ethylene glycol ether and a propylene glycol ether.4. The pesticidal composition of wherein the glycol ether is one or two compounds selected from the group consisting of ethylene glycol monobutyl ether and diethylene glycol monobutyl ether.5. The pesticidal composition of wherein the glycol ether is at least one compound selected from the group consisting of ethylene glycol monobutyl ether claim 1 , diethylene glycol monobutyl ether claim 1 , propylene glycol monomethyl ether claim 1 , propylene glycol monoethyl ether claim 1 , and propylene glycol monopropyl ether.6. The pesticidal composition of wherein the glycol ether content is from 15 wt % to 40 wt % of the total amount of the composition.7. The pesticidal composition of wherein the ester compound of Formula (1) is at least one compound selected from the group consisting of:[2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-(1-propenyl)cyclopropane-carboxylate,[2,3,5,6-tetrafluoro-4-methylphenyl]methyl 2,2-dimethyl-3-(1-propenyl)cyclopropane-carboxylate,(2,3,5,6-tetrafluorophenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-carboxylate, and[2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 3-(2,2-dichlorovinyl ...

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Номер записи: 87

21-11-2013 дата публикации

NOVEL POLYMORPH FORMS OF (2S)-(4E)-N-METHYL-5-[3-(5-ISOPROPOXYPYRIDIN)YL]-4-PENTEN-2-AMINE

Номер: US20130310425A1

Автор: Dull Gary Maurice, Munoz Julio A.

Принадлежит: Targacept, Inc.

Polymorph forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine p-hydroxybenzoate, and methods for their preparation, pharmaceutical composition containing said polymorph(s) and use, are disclosed. The polymorphs can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders. 1. A method for treatment of a central nervous system disorder , comprising administering to a mammal , in need of such treatment , a therapeutically effective amount of:a crystalline polymorph B of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine p-hydroxybenzoate, exhibiting an X-ray powder diffraction pattern having characteristic peaks expressed in degrees (2-0°) at around 8.0, 9.,6 and 16.1; ora mixture of polymorphs comprising polymorph A of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine p-hydroxybenzoate, exhibiting an X-ray powder diffraction pattern having characteristic peaks expressed in degrees (2-0°) at around 7.6, 15.2, and 19.7; and polymorph B of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine p-hydroxybenzoate, exhibiting an X-ray powder diffraction pattern having characteristic peaks expressed in degrees (2-0°) at around 8.0, 9.6, and 16.1, in ratios of 5:95 to 95:5.2. The method of claim 1 , wherein the disorder is selected from the group consisting of age-associated memory impairment claim 1 , mild cognitive impairment claim 1 , presenile dementia claim 1 , early onset Alzheimer's disease claim 1 , senile dementia claim 1 , dementia of the Alzheimer's type claim 1 , Lewy body dementia claim 1 , vascular dementia claim 1 , Alzheimer's disease claim 1 , stroke claim 1 , AIDS dementia complex claim 1 , attention deficit disorder claim 1 , attention deficit hyperactivity disorder claim 1 , dyslexia claim 1 , schizophrenia claim 1 , schizophreniform disorder claim 1 , and schizoaffective disorder.3. ...

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Номер записи: 88

28-11-2013 дата публикации

PESTICIDE COMPOSITION FOR SHORTENING THE VIRUS LETHAL TIME

Номер: US20130315873A1

Автор: HSU Ju-Chun, SHIH Cheng-Jen, TUAN Shu-Jen, WANG Hsiang-Chuan

Принадлежит: NATIONAL TAIWAN UNIVERSITY

The present invention is related to a pesticide composition for shortening the virus lethal time that comprises 0.01-75% of a ryanodine receptor insecticide or a diamides insecticide and 10-10PIB/ml of baculovirus. The pesticide composition of the present invention can effectively reduce the lethal time to the pest compared to the baculovirus alone, and also can increase the control effect of the pest compared to the same concentration of the insecticide. 1. A pesticide composition comprising: (a) a ryanodine receptor insecticide or a diamides insecticide and (b) baculovirus , wherein the concentration of the ryanodine receptor insecticide or the diamides insecticide is 0.01-75% and the concentration of the baculovirus is 10-10PIB/ml.2. The pesticide composition of claim 1 , wherein the concentration of the ryanodine receptor insecticide or the diamides insecticide is 0.1-50% and the concentration of the baculovirus is 10-10PIB/ml.3. The pesticide composition of claim 1 , wherein the concentration of the ryanodine receptor insecticide or the diamides insecticide is 0.1-40% and the concentration of the baculovirus is 10-10PIB/ml.4. The pesticide composition of claim 1 , which controls pests of moths claim 1 , flies or beetles.5. The pesticide composition of claim 1 , which is sprayed directly claim 1 , seed-treated claim 1 , distributed in fields or mixed with baits or other attractant substances after dilution to achieve pesticidal effects.6. The pesticide composition of claim 5 , wherein the dilution is 100-3000 folds.7. The pesticide composition of claim 1 , which shortens pesticidal time of the baculovirus to pest by more than two folds.8. The pesticide composition of claim 1 , wherein the ryanodine receptor insecticide is chlorantraniliprole claim 1 , flubendiamide or cyantraniliprole.9nucleopolyhedrovirus.. The pesticide composition of claim 1 , wherein the baculovirus is10. The pesticide composition of claim 1 , wherein the concentration of the ryanodine ...

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Номер записи: 89

28-11-2013 дата публикации

INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS

Номер: US20130317062A1

Автор: Cassayre Jerome Yves, Corsi Camilla, Maienfisch Peter, Pitterna Thomas

Принадлежит: SYNGENTA PARTICIPATIONS AG

A compound of formula (I) 2. A compound according to wherein Ris pyrid-4-yl optionally substituted by one or two substituents each independently selected from fluoro claim 1 , chloro claim 1 , bromo claim 1 , methyl claim 1 , difluoromethyl claim 1 , chlorodifluoromethyl or trifluoromethyl.3. A compound according to wherein Ris hydrogen claim 1 , halogen claim 1 , cyano claim 1 , C-Calkyl claim 1 , C-Chaloalkyl claim 1 , C-Calkenyl claim 1 , C-Ccycloalkyl claim 1 , C-Calkoxy claim 1 , C-Chaloalkoxy claim 1 , C-Calkylthio or C-Chaloalkylthio.4. A compound according to wherein Ris hydrogen claim 1 , halogen claim 1 , cyano claim 1 , C-Calkyl claim 1 , C-Chaloalkyl claim 1 , C-Calkenyl claim 1 , C-Ccycloalkyl claim 1 , C-Calkoxy claim 1 , C-Chaloalkoxy claim 1 , C-Calkylthio or C-Chaloalkylthio.5. A compound according to wherein Ris hydrogen claim 1 , fluoro claim 1 , chloro or bromo.6. A compound according to wherein each Ris independently halogen claim 1 , C-Calkyl or C-Calkoxy.7. A compound according to wherein m is 0 or 1.8. A compound according to wherein each Ris independently halogen claim 1 , C-Calkyl or C-Calkoxy.9. A compound according to wherein n is 0 or 1.10. A compound according to wherein Ris hydrogen claim 1 , halogen claim 1 , cyano claim 1 , C-Calkyl claim 1 , C-Chaloalkyl claim 1 , C-Ccycloalkyl claim 1 , C-Calkenyl claim 1 , C-Chaloalkenyl claim 1 , C-Calkynyl claim 1 , C-Calkoxy or C-Chaloalkoxy.12. An insecticidal claim 1 , acaricidal claim 1 , nematicidal or molluscicidal composition comprising an insecticidally claim 1 , acaricidally claim 1 , nematicidally or molluscicidally effective amount of a compound of formula (I) as defined in .13. The method according to wherein Ris pyrid-4-yl optionally substituted by one or two substituents each independently selected from fluoro claim 11 , chloro claim 11 , bromo claim 11 , methyl claim 11 , difluoromethyl claim 11 , chlorodifluoromethyl or trifluoromethyl.14. The method according to wherein Ris ...

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Номер записи: 90

28-11-2013 дата публикации

PESTICIDAL MIXTURES WITH IMPROVED PROPERTIES

Номер: US20130317067A1

Автор: Hungenberg Heike, JESCHKE Peter, Olenik Britta, Velten Robert

Принадлежит: Bayer Intellectual Property GmbH

The present invention relates to novel pesticidal compositions comprising the crystalline modification I of 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one and a fungicidally active compound that show surprisingly good insecticidal, acaricidal, nematicidal and fungicidal activities. In particular, these compositions are suited for the treatment of seed. 1. A composition comprising the crystalline modification I of 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one and a fungicide of group A selected from the subgroups (1) to (16):(1) Inhibitors of the ergosterol biosynthesis: Aldimorph, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, dodemorph, dodemorph acetate, epoxiconazole, etaconazole, fenarimol, fenbuconazole, fenhexamid, fenpropidin, fenpropimorph, fluquinconazole, flurprimidol, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imazalil, imazalil sulfate, imibenconazole, ipconazole, metconazole, myclobutanil, naftifine, nuarimol, oxpoconazole, paclobutrazol, pefurazoate, penconazole, piperalin, prochloraz, propiconazole, prothioconazole, pyributicarb, pyrifenox, quinconazole, simeconazole, spiroxamine, tebuconazole, terbinafine, tetraconazole, triadimefon, triadimenol, tridemorph, triflumizole, triforine, triticonazole, uniconazole, uniconazole-p, viniconazole, voriconazole, 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol, methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate, N′-{5-(difluoromethyl)-2-methyl-4-[3-(trimethylsilyl)propoxy]phenyl}-N-ethyl-N-methylimidoformamide, N-ethyl-N-methyl-N′-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imidoformamide and O-[1-(4-methoxyphenoxy)-3,3-dimethylbutan-2-yl]1H-imidazole-1-carbothioate;(2) inhibitors of the respiratory chain at complex I or II: Bixafen, boscalid, carboxin, diflumetorim, fenfuram, fluopyram, flutolanil, fluxapyroxad, furametpyr, ...

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Номер записи: 91

05-12-2013 дата публикации

FUNGICIDAL COMPOSITIONS AND METHODS

Номер: US20130324400A1

Автор: Doran David, Riggs Jennifer

Принадлежит: BAYER CROPSCIENCE LP

Provided are methods for reducing the occurrence of sudden death syndrome in plants, such as soybeans, using compounds of the general formula (I). 2. The method of wherein p is 2.3. The method of wherein q is 1 or 2 claim 1 , and the substituent(s) Y is/are positioned in the ortho position of the benzene ring.6. The method of claim 5 , wherein the applying is to a soybean seed claim 5 , a soybean root claim 5 , or to soil in which soybean is growing or in which it is desired to grow claim 5 , or to a combination thereof.7. The method of claim 6 , wherein reducing the occurrence comprises reducing mean disease severity compared to seed claim 6 , plants claim 6 , or plant roots not treated with a compound of general formula (I).8. The method of claim 6 , wherein reducing the occurrence comprises increasing yield as compared to seed claim 6 , plants claim 6 , or roots not treated with a compound of general formula (I).10. The method of wherein p is 2.11. The method of wherein q is 1 or 2 claim 9 , and the substituent(s) Y is/are positioned in the ortho position of the benzene ring.14. The method of claim 13 , wherein the applying is to a soybean seed claim 13 , a soybean root claim 13 , or to soil in which soybean is growing or in which it is desired to grow claim 13 , or to a combination thereof.15. The method of claim 13 , wherein reducing the occurrence comprises reducing mean disease severity compared to seed claim 13 , plants claim 13 , or plant roots not treated with a compound of general formula (I).17. The seed of wherein p is 2.18. The seed of wherein q is 1 or 2 claim 16 , and the substituent(s) Y is/are positioned in the ortho position of the benzene ring. 1. FieldThe present invention relates to methods and compositions for preventing, treating, and/or ameliorating fungal diseases and/or nematodes in plants via application to plant roots, seed, and/or soil of at least one pyridinyl ethylbenzamide derivative.2. Description of Related ArtSudden death syndrome ...

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Номер записи: 92

05-12-2013 дата публикации

6-(2-Aminophenyl)picolinates and their use as herbicides

Номер: US20130326735A1

Автор: BRÜNJES Marco, DIETRICH Hansjörg, Döller Uwe, GATZWEILER ELMAR, Häuser-Hahn Isolde, Heinemann Ines, Hoffmann Michael Gerhard, ROSINGER CHRISTOPHER HUGH

Принадлежит: Bayer Intellectual Property GmbH

The present invention relates to novel herbicidally active 6-(2-aminophenyl)picoline derivatives and to processes for preparation thereof. The present invention further provides for the use thereof as a herbicide, especially as a herbicide for selective control of weed plants in useful plant crops, and as a plant growth regulator alone or in combination with safeners and/or in a mixture with other herbicides. 3. The compound as claimed in claim 1 , in which the radicals are each defined as follows:n is an integer selected from the group consisting of 0, 1, 2, 3, and 4;{'sup': 1', '1', '1, 'sub': 1', '6', '1', '6', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '1', '6', '1', '6', '2', '6', '1', '6', '2', '6', '1', '6', '1', '6', '1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '2', '6', '3', '8', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '2', '2', '2, 'Ris, optionally independently of further Rradicals, selected from the group consisting of hydrogen, halogen, cyano, nitro, amino, (C-C)alkyl, (C-C)haloalkyl, (C-C)alkoxyalkyl, (C-C)haloalkoxyalkyl, (C-C)alkenyl, (C-C)haloalkenyl, (C-C)alkynyl, (C-C)alkoxy, (C-C)haloalkoxy, (C-C)haloalkenyloxy, (C-C)alkylthio, (C-C)alkylthioalkyl, (C-C)haloalkylthio, (C-C)alkylsulfonyl, (C-C)haloalkylsulfonyl, (C-C)alkenylthio, (C-C)haloalkenylthio, (C-C)alkylamino, (C-C)dialkylamino, (C-C)alkylaminoalkyl, (C-C)alkylcarbonyl, (C-C)alkoxycarbonyl, (C-C)aminocarbonyl, (C-C)alkylaminocarbonyl, (C-C)dialkylaminocarbonyl, or two adjacent Rradicals together form an —OCHO—, —CHCHO—, —OCHCHO—, —OCH(CH)O—, —OC(CH)O—, —OCFO—, —CFCFO—, —OCFCFO— or —CH═CH—CH═CH— group;'}{'sup': '2', 'Ris hydrogen, halogen, cyano;'}{'sup': 3', '9', '10', '11', '12', '13', '14', '15, 'sub': 1', '4', '2', '4', '2', '4', '2, 'Ris hydrogen, (C-C)alkyl, (C-C)alkenyl, (C-C)alkynyl or C(═O)R, OR, S(O)R, N(R)Ror N═C(R)R;'}{'sup': 4', '6', '9, 'sub': 1', '4, 'Ris hydrogen, (C-C)alkyl optionally substituted by one or two ...

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Номер записи: 93

12-12-2013 дата публикации

VIRAL POLYMERASE INHIBITORS

Номер: US20130331391A1

Автор: BEAULIEU Pierre L., FORGIONE Pasquale, GAGNON Alexandre, GODBOUT Cedrickx, JOLY Marc-Andre, LLINAS-BRUNET Montse, NAUD Julie, POIRIER Martin, RANCOURT Jean

Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Compounds of formula I: 2. The compound according to , or a pharmaceutically acceptable salt thereof , wherein X is O , and R , R , R , R , R , and Rare as defined in .5. The compound according to claim 4 , or a pharmaceutically acceptable salt thereof claim 4 , wherein Ris H or CF claim 4 , and Ris selected from:{'sub': '1-3', 'sup': '7', '—(C)alkylene-R;'}{'sup': '7', 'wherein Ris Het; wherein the Het is a 5- or 6-membered heterocycle containing 1 to 4 heteroatoms, each independently selected from N, O and S, or Het is a 9- or 10-membered heteropolycycle containing 1 to 4 heteroatoms, each independently selected from N, O and S;'}{'sub': '2', 'wherein each N heteroatom may, independently and where possible, exist in an oxidized state such that it is further bonded to an oxygen atom to form an N-oxide group and wherein each S heteroatom may, independently and where possible, exist in an oxidized state such that it is further bonded to one or two oxygen atoms to form the groups SO or SO;'}{'sub': 1-6', '1-6', '3-7', '2', '1-4', '3-7', '1-4', '3-7', '1-4', '2', '1-4', '1-6, 'wherein the Het is optionally substituted with 1 to 3 substituents each independently selected from halo, cyano, oxo, imino, —OH, —O—(C)alkyl, —O—(C)haloalkyl, (C)cycloalkyl, —NH, —NH(C)alkyl, —NH(C)cycloalkyl, —N((C)alkyl)(C)cycloalkyl, —N((C)alkyl), —NH—C(═O)(C)alkyl, (C)alkyl and Het, wherein the Het is a 5- or 6-membered heterocycle containing 1 to 4 heteroatoms, each independently selected from N, O and S.'}6. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris selected from H claim 1 , F claim 1 , Cand CH.7. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris selected from H claim 1 , F and CH.8. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris selected from H claim 1 , F claim 1 , Cl claim 1 , CHand CN.9. The compound according to claim 1 , or ...

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Номер записи: 94

12-12-2013 дата публикации

INSECTICIDAL MIXTURES WITH IMPROVED PROPERTIES

Номер: US20130331417A1

Автор: Hungenberg Heike, JESCHKE Peter, Olenik Britta, Velten Robert

Принадлежит: Bayer Intellectual Property GmbH

The present invention relates to novel pesticidal compositions comprising the crystalline modification I of 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino} furan-2(5H)-one and a insecticide, acaricide or nematicide that show surprisingly good insecticidal, acaricidal, nematicidal and fungicidal activities. In particular, these compositions are suited for the treatment of seed. 1. A composition comprising a crystalline modification I of 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino} furan-2(5H)-one and an insecticide , an acaricide or a nematicide of group (A) selected from the subgroups (1) to (29):(1) Acetylcholinesterase (AChE) inhibitors: Carbamates, alanycarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC, and xylylcarb; or organophosphates, acephate, azamethiphos, azinphos (-methyl, -ethyl), cadusafos, chlorethoxyfos, chlorfenvinphos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl), coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, isofenphos, isopropyl O-(methoxyaminothio-phosphoryl) salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos (-methyl), profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, and vamidothion;(2) GABA-gated chloride channel antagonists: Organochlorines, chlordane, endosulfan (alpha-); or fiproles (phenylpyrazoles), ethiprole, fipronil, ...

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Номер записи: 95

12-12-2013 дата публикации

Methods for Preventing Flea Allergy Dermatitis in Companion Animals

Номер: US20130331418A1

Автор: Larry Nouvel

Принадлежит: Sergeant's Pet Care Products Inc

Methods for reducing the incidence of flea allergy dermatitis (FAD) in a companion animal are disclosed, the methods directed to inhibiting blood feeding by ectoparasites on a companion animal. The methods of the present invention involve administering a pesticide composition comprising cyphenothrin to a companion animal, specifically dogs and cats, in doses and proportions which are parasiticidally effective against a variety of ectoparasites, and in formulations which are convenient for topical application to the animal's skin, preferably localized over a small surface area. Such methods are useful in preventing and/or reducing the incidence of flea allergy dermatitis.

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Номер записи: 96

19-12-2013 дата публикации

RADIOFLUORINATION METHOD

Номер: US20130338361A1

Автор: Betts Helen May, Khan Imtiaz, ROBINS EDWARD GEORGE

Принадлежит: GE HEALTHCARE LIMITED

Provided by the present invention is a novel method for obtaining an F-labelled compound wherein said compound comprises an F-labelled pyridyl ring. The method of the invention is advantageous over the prior art methods as it provides these compounds in higher radiochemical yields than have been possible with previous methods. Also provided by the present invention is an F-labelled synthon useful in the method of the invention. 4) The method as defined in which further comprises the step:{'sup': 18', '18, '(ii) coupling the F-labelled synthon of Formula Y as defined herein with a cross-coupling partner in a transition metal-mediated coupling reaction to obtain an F-labelled product.'}5) The method as defined in wherein said transition metal is palladium.12) The method as defined in which is automated. The present invention relates to a method for radiosynthesis and more specifically a novel method for the synthesis of F-labelled compounds. The invention also relates to a novel synthon for use in the inventive method of synthesis.In order to expand the range of applications for positron emission tomography (PET) there is an interest in developing synthetic methods for new PET tracers, i.e. biologically useful compounds labelled with C, F or Br. Currently, the most widely-used of these radiotracers for PET imaging is F.Typically, the synthesis of a PET tracer including its purification should be completed within three half-lives of the radiotracer. F has a relatively short half-life of 109.7 minutes and as such methods for its incorporation into a PET tracer demands fast and high-yielding reactions that can be performed on a small scale and under mild conditions.Direct labelling is desirable as it introduces F at the last possible step. However, direct labelling tends only to be possible using [F]fluoride in a nucleophilic substitution reaction can require the presence of activating groups, proton-free conditions and typically high temperatures of above 100° C. The ...

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Номер записи: 97

26-12-2013 дата публикации

LOCAL TOPICAL ADMINISTRATION FORMULATIONS CONTAINING INDOXACARB

Номер: US20130345210A1

Автор: "ONeil Peter Andrew", Freehauf Keith Alan, Guerino Frank, Sargent Roger Mervyn, Simmons Robert D., Wang Chen-Chao

Принадлежит:

The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil. 1. A local , topical , spot-on formulation for control of ectoparasites on a domestic animal comprising an ectoparasitically effective amount of Indoxacarb , a veterinarily acceptable carrier , and a pyrethroid pesticide.2. The formulation of claim 1 , wherein said ectoparasite is an Arthropod.3. The formulation of claim 2 , wherein said Arthropod is an Insecta.4. The formulation of claim 3 , wherein said Insecta is a flea claim 3 , fly claim 3 , or louse.5. The formulation of claim 2 , wherein said Arthropod is an Arachnida.6. The formulation of claim 1 , wherein the concentration of Indoxacarb in said formulation is at least 200 g/L.7. The formulation of claim 1 , wherein the concentration of Indoxacarb in said formulation is at least 150 g/L.8. The formulation of claim 1 , wherein the concentration of Indoxacarb is at least 100 g/L.9. The formulation of claim 1 , wherein said veterinarily acceptable carrier comprises one or more of a solvent claim 1 , crystallization inhibitor claim 1 , adjuvant claim 1 , co-solvent claim 1 , colorant claim 1 , surfactant claim 1 , spreading oil claim 1 , antioxidant claim 1 , light stabilizer or tackifier.10. The formulation of claim 9 , wherein said solvent comprises a glycol ether.11. The formulation of claim 10 , wherein said glycol ether comprises dipropylene glycol monomethyl ether.12. The formulation of claim 9 , wherein said solvent comprises an alkyl acetate.13. The formulation of claim 12 , wherein said alkyl acetate is ethyl acetoacetate.14. The formulation of claim 9 , wherein said crystallization inhibitor is triacetin.15. The ...

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Номер записи: 98

26-12-2013 дата публикации

Pest control composition and pest control method

Номер: US20130345266A1

Автор: Yoshito Tanaka

Принадлежит: Sumitomo Chemical Co Ltd

The present invention provides a pest control composition containing a combination of (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine(clothianidin) and an ester compound represented by formula (I).

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Номер записи: 99

26-12-2013 дата публикации

METHOD FOR SYNTHESIZING PIRFENIDONE

Номер: US20130345430A1

Автор: Cyr Michael, Pyles Sabine M., Radhakrishnan Ramachandran

Принадлежит: INTERMUNE, INC.

A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. 2. The method of claim 1 , further comprising washing the pirfenidone with a saline solution.3. The method of claim 1 , further comprising extracting the pirfenidone from the organic solvent mixture with an extracting organic solvent.4. The method of claim 3 , wherein the extracting organic solvent comprises toluene.5. The method of claim 1 , further comprising admixing a base with the bromobenzene claim 1 , 5-methyl-2-pyridone claim 1 , cuprous oxide claim 1 , and organic solvent.6. The method of claim 5 , wherein the base comprises a carbonate.7. The method of claim 6 , wherein the carbonate comprises potassium carbonate.8. The method of claim 1 , wherein the organic solvent comprises dimethyl formamide.9. The method of claim 1 , further comprising crystallizing the pirfenidone from a solvent mixture comprising heptanes and toluene to form purified pirfenidone.10. The method of claim 9 , further comprising recrystallizing the purified pirfenidone bydissolving at least a portion of the purified pirfenidone in an acidic aqueous solution at an elevated temperature to form a pirfenidone solution;adding a base to the pirfenidone solution until the pH is at least about 11 to form a basic pirfenidone solution; andcooling the basic pirfenidone solution to a temperature below about 20° C. to form recrystallized pirfenidone.11. The method of claim 9 , comprising performing the crystallizing in the absence of ethyl acetate and in the absence of butanol.13. The pirfenidone of claim 12 , wherein the method further ...

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Номер записи: 100