06-06-2013 дата публикации
Номер: US20130143929A1
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, 2. A compound of wherein:{'sup': 1', '5a', '5a, 'Qis a phenyl ring substituted with 1 to 3 substituents independently selected from R; or a pyridinyl or pyrimidinyl ring optionally substituted with up to 3 substituents independently selected from R;'}{'sup': 2', '5a', '5a, 'Qis a phenyl ring substituted with 1 to 3 substituents independently selected from R; or a pyrazolyl, pyridinyl or pyrimidinyl ring optionally substituted with up to 3 substituents independently selected from Ron carbon atom ring members and methyl on the nitrogen atom ring member;'}{'sup': 1', '2, 'sub': 1', '3, 'Rand Rare each independently H, halogen, cyano, C-Calkyl or cyclopropyl;'}{'sup': 3', '6, 'Ris Br, Cl, F, —ORor —SC≡N;'}{'sup': '4', 'Ris H or methyl;'}{'sup': '5a', 'sub': 1', '2', '1', '2', '1', '2', '1', '2, 'each Ris independently halogen, cyano, C-Calkyl, C-Chaloalkyl, cyclopropyl, C-Calkoxy, C-Calkylthio or -T-U—V;'}{'sup': '6', 'sub': 1', '3', '1', '2', '2', '3', '2', '4', '2', '4', '2', '4', '2', '4', '2', '4, 'Ris H, —CH(═O), C-Calkyl, C-Chaloalkyl, C-Calkoxyalkyl, C-Ccyanoalkyl, C-Calkylcarbonyl, C-Calkoxycarbonyl, C-C(alkylthio)carbonyl or C-Calkoxy(thiocarbonyl);'}each T is independently O, NH or a direct bond;{'sub': 1', '3, 'each U is independently C-Calkylene, wherein up to 1 carbon atom is selected from C(═O);'}{'sup': 8a', '8b', '9, 'each V is independently N(R)(R) or OR;'}{'sup': 8a', '8b, 'each Rand Ris independently H or methyl; and'}{'sup': '9', 'each Ris independently H, methyl or halomethyl.'}3. A compound of wherein{'sup': 1', '5a, 'Qis a phenyl ring substituted with 1 to 3 substituents independently selected from R;'}{'sup': 2', '5a, 'Qis a phenyl ring substituted with 1 to 3 substituents independently selected from R;'}{'sup': 1', '2, 'sub': 1', '2, 'Rand Rare each independently H, Cl, Br, I or C-Calkyl; and'}{'sup': '5a', 'each Ris independently halogen, cyano, ...
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