18-07-2013 дата публикации
Номер: US20130184317A1
Принадлежит:
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein. 181-. (canceled)83. The compound of wherein{'sup': 2', '6', '6a', '6b, 'sub': 6', '20', '2, 'Ris a C-Calkyl, optionally substituted with one or more substituents independently selected from halogen, —OH, —NH, —NHC(O)R, and —NRR;'}{'sup': 6', '7', '7', '7', '7, 'sub': 3', '2', '3', '2', '2', '3', '6', '5', '6', '4', '2', '6', '5', '2', '6', '4', '1', '20', '1', '20', '2', '3', '2', '3', '2', '2', '3', '1', '6', '6', '5', '6', '4', '2', '6', '5', '2', '6', '4, 'Ris —CH, —CHCH, —CHCHCH, —CH, —CHR, —CHCH, —CHCHR, aryl, heteroaryl, or —C-Calkyl, wherein each of the aryl, heteroaryl, or —C-Calkyl may optionally be substituted with one or more substituents independently selected from —NH, —OH, —CH, —CHCH—CHCHCH—C-Calkyl, —CH, —CHR, —CHCH, —CHCHRand halogen;'}{'sup': '6a', 'Rmay be H or methyl;'}{'sup': '6b', 'sub': 6', '5, 'Rmay be methyl 7-nitrobenzene[c][1,2,5]oxadiazole-4-yl, or —C(O)CH; and'}{'sup': '7', 'sub': 3', '3', '3', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2, 'Rmay be —H, —CH, heteroaryl, —C(CH), —OH, —NH, —NHC(O)CH, —S(O)OH, —P(O))H, —As(O)OH, —NO, —OCH, —OCHCH, —C(O)OH, —C(O)NH, or halogen.'}84. The compound of or pharmaceutically acceptable salt thereof claim 82 , wherein Ris a C-Calkyl.85. The compound of or pharmaceutically acceptable salt thereof claim 82 , wherein Ris a straight C-Calkyl.86. The compound of or pharmaceutically acceptable salt thereof claim 82 , wherein Ris a C-Calkyl.87. The compound of or pharmaceutically acceptable salt thereof claim 82 , wherein Ris a C-Calkyl.88. The compound of or pharmaceutically acceptable salt thereof claim 82 , wherein Ris a C-Calkyl.89. The compound of or pharmaceutically acceptable salt thereof claim 82 , wherein Ris —(CH)CH.92. The pharmaceutical composition of claim 91 , wherein:{'sup': 2', '6', '6a', '6b, 'sub': 6', '20', '2, 'Ris a C-Calkyl, optionally ...
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