12-05-1971 дата публикации
Номер: GB1231613A
Автор:
Принадлежит:
1,231,613. Dibenzazepines. YOSHITOMI PHARMACEUTICAL INDUSTRIES Ltd. 2 July, 1968 [3 July, 1967; 7 Feb., 1968], No. 31450/68. Heading C2C. Novel dibenzazepine derivatives of Formula (I) in which R is hydrogen or chlorine, R<SP>1</SP> is hydroxy, cyano, carbamoyl, methoxy or acetyl and R<SP>2</SP> is phenyl, tolyl, trifluoromethyl-phenyl, benzyl, dimethylamino or piperidino, or R<SP>1</SP> and R<SP>2</SP> together represent the group -S-CH 2 - CO-N(R<SP>3</SP>)- in which R<SP>3</SP> is H, phenyl, tolyl or trifluoromethyl-phenyl, and pharmaceutically acceptable acid addition salts thereof, are prepared by reacting a compound of Formula (II) with a compound of Formula (III) in which X is hydrogen, an alkali metal atom or -CH 2 CH 2 CH 2 Q and Y is -CH 2 CH 2 CH 2 Q when X is hydrogen or an alkali metal atom or is hydrogen when X is -CH 2 CH 2 CH 2 Q, Q being a halogen atom or a reactive acid residue, and optionally converting a compound (I) into a pharmaceutically acceptable acid addition salt. Pharmaceutical compositions having vasodilating activity for oral or parenteral administration, comprise a compound (I), or a pharmaceutically acceptable acid addition salt thereof, together with a carrier.
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