SULFOBENZOYL HYDRAZONES

1,210,539. Sulphobenzoylhydrazones. ROUSSEL UCLAF. 22 Dec., 1967 [26 Dec., 1966; 23 March, 1967], No. 58466/67. Headings C2A, C2C and C2U. The invention comprises compounds of the Formula I in which the sulpho group is in the 3- or 4-position of the benzene ring wherein Y represents hydrogen when the group = C-Z represents the residue of an aldehyde of the formula O=CHZ or =C(Y)Z represents the residue of a ketone or quinone of the formula O=C(Y)Z, and salts thereof with bases e.g. tetracycline and their preparation by reacting a corresponding hydrazide of the Formula II or a salt thereof with an aldehyde, ketone or quinone in the presence of a metal, ammonia or organic base salt of a carboxylic acid. Examples of compounds of the formula O=C(Y)Z are 3#-hydroxy- 17-oxo-androst-5-ene, isatin; N- propyl-, N-benzyl- and 5-nitro-isatin, 3#- hydroxy - 20 - oxo - pregn - 5 - ene and 5- nitrofurfuraldehyde. Therapeutic compositions in forms suitable for oral, parenteral, rectal or topical administration comprise compounds of the Formula I wherein Y represents a hydrogen atom and Z a 5-nitro-2-furyl group or non-toxic salts thereof together with a suitable carrier.