25-07-2013 дата публикации
Номер: US20130190361A1
Disclosed are compounds of Formula (I): 2. The compound according to or stereoisomers claim 1 , N-oxides claim 1 , or salts thereof; wherein:Ring A is phenyl or 5- to 6-membered heteroaryl having at least one N or S heteroatom;{'sub': 1', '2', '1-3, '(i) Rand Rare independently Calkyl; or'}{'sub': 1', '2', '3-7', 'a, '(ii) Rand Rtogether with the carbon atom to which they are attached, form a cyclic group selected from Ccycloalkyl and 4- to 6-membered heterocycloalkyl, wherein each of said cycloalkyl and heterocycloalkyl rings is substituted with zero to 4 R;'}{'sub': '3', 'claim-text': [{'sub': 1-4', '3', '1-3', '3', 'm', '1-2', '2, '(i) F, Cl, Calkyl, —CF, —O(Calkyl), —OCF, —S(O)(Calkyl), and/or —NH; and/or'}, {'sub': 2', '1', '1', '2', '1', '2', '1', '2', '2', '1', '1', '2', '1-3', '3', '1-2, '(ii) —CHA, —OA, —OCHA, —CHOA, and/or —CHSOA, wherein Ais phenyl, pyridinyl, thiazolyl, or imidazolyl substituted with zero to 2 substituents independently selected from F, Cl, —NH, Calkyl, —CF, and/or Calkoxy;'}], 'each Ris independently{'sub': '1', 'claim-text': [{'sub': b', 'b', '2-4, '(a) —(CRR)—,'}, {'sub': 2', '0-2', 'c', 'c', '2', '0-2, '(b) —(CH)—CR═CR—(CH), or'}, {'sub': 2', '0-2', '2', '1-2, '(c) —(CH))(CH)—;'}], 'Lis{'sub': '2', 'claim-text': (a) a bond,', {'sub': b', 'b', '1-4, '(b) —(CRR),'}, {'sub': 2', '0-2', 'c', 'c', '2', '0-2, '(c) —(CH)—CR═CR—(CH), or'}, {'sub': 2', '0-2', '2', '1-2, '(d) —(CH)O(CH)—;'}], 'Lis{'sub': 1-3', '2', '2', '3', '1-2', '3, 'Q is phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents independently selected from F, Cl, Calkyl, —CN, —NO, —NH, —CF, Calkoxy, and/or —OCF;'}{'sub': a', '3', 'a, 'each Ris independently F, Cl, and/or —CH; and/or two Rattached to the same carbon atom form ═O;'}{'sub': b', '3', '1-2', 'b', 'b, 'each Ris independently H, —CH, F, —OH, and/or Calkoxy, provided that if one Ris —OH, then the second Rattached to the same carbon is not —OH or F; and'}{'sub': c', '3, 'each Ris independently H, ...
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