02-01-2014 дата публикации
Номер: US20140005190A1
Автор:
Baell Jonathan Bayldon,
Bui Chinh Thien,
COLMAN PETER,
CZABOTAR PETER,
DUDLEY DANETTE A.,
Elmore Steven W.,
FAIRBROTHER WAYNE J.,
Flygare John A.,
Lessene Guillaume Laurent,
Ndubaku Chudi,
NIKOLAKOPOULOS GEORGE,
PETROS ANDREW M.,
RYE CARL STEVEN,
SLEEBS BRAD EDMUND,
SMITH BRIAN JOHN,
Souers Andrew J.,
WATSON KEITH GEOFFREY
Принадлежит:
In one aspect, the present invention provides for a compound of Formula I 125-. (canceled)29. The compound or pharmaceutically acceptable salt of claim 28 , wherein Xis —CH— or —O—.31. The compound or pharmaceutically acceptable salt of claim 30 , wherein Xis —CH— or —O—.32. The compound or pharmaceutically acceptable salt of claim 26 , wherein L is absent or is an optionally substituted group selected from the group consisting of Carylene-Cheteroalkylene claim 26 , Cheteroarylene-Cheteroalkylene claim 26 , Cheteroalkylene claim 26 , Cheteroalkenylene claim 26 , Calkylene claim 26 , Calkenylene claim 26 , Calkynylene claim 26 , and —O—; and{'sub': 5-6', '3-7', '3-7', '2', '2', '2', '3', '2', '2', '1-6', '2-6', '2-6', '1-6', '1-6', '1-6', '2-6', '2-6', '3-7', '3-7', '2', '1-4', '1-6', '1-6', '2-6', '2-6', '3-7', '3-7', '2', '1-4', '1-6', '2-6', '2-6', '1-6', '1-6', '1-6', '2-6', '2-6', '3-7', '3-7', '1-6', '1-6', '2-6', '2-6', '3-7', '3-7', '2', '1-4, 'sup': 6', 'p', 'q', 'p', 'p', 'p', 'p', 'q', 'p', 'p', 'q', 'r', 'p', 'p', 'q', 'p', 'q', 'p', 'r', 'r', 'p', 'q', 'r', 's', '1', 'p', 'q', '1', 'p', '1', 'p', '1', 'p', 'q', '1', 'p', 'r', '1', 'r', '1', 's', '1', 'p', 'q', '1', 'p', 'q', 'r', '6', 'p', 'q', 'p', 'r', 's', 's', 's', 's', '7', 't', 'u', 't', 't', 't', 'u', 't', 'v', 'v', '2', 't', 'u', '2', 't', 'u', '2', 'v', '2', 't', 'u', 'v', '7', 't', 'u', 't', 'v, 'E is a ring selected from the group consisting of phenyl, Cheteroaryl, Cheterocycloalkyl, and Ccycloalkyl, and wherein optionally fused to E is a 5- to 7-membered heterocyclic ring, a benzene ring, or a 5- to 6-membered heteroaromatic ring, and wherein E and said ring optionally fused to E are substituted with 0 to 5 Rsubstituents selected from the group consisting of fluoro, chloro, bromo, —NRR, —SR, —OR, —C(O)OR, —C(O)NRR, —C(O)R, —NRC(O)R, —OC(O)R, —NRC(O)NRR, —OC(O)NRR, —NRC(O)OR, —S(O)R, —S(O)NRR, —R, —R, —NO, —N, —CN, —Z—NRR, —Z—SR, —Z—OR, —Z—OC(O)NRR, —Z—NRC(O)OR, —Z—S(O)R, —Z—R, and —Z—S(O)NRR; ...
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