05-05-2016 дата публикации
Номер: US20160122337A1
Принадлежит:
The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory. 2. Compounds according to claim 1 , of the formula (I) claim 1 , in which{'sup': '1', 'Ris 1-azabicyclo[2.2.2]oct-3-yl,'}{'sup': '2', 'sub': 1', '4, 'Ris hydrogen or C-C-alkyl,'}{'sup': '3', 'sub': 1', '4, 'Ris hydrogen, fluorine, chlorine, bromine or C-C-alkyl,'}{'sup': '4', 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '3', '6', '3', '6', '1', '4, 'claim-text': {'sub': 1', '4', '1', '4', '1', '4, 'claim-text': [{'sub': 1', '4', '1', '4', '1', '4, 'C-C-alkylaminocarbonyl may optionally be substituted by C-C-alkoxy or C-C-alkylamino,'}, {'sub': 1', '4', '1', '4, 'C-C-alkylcarbonylamino may optionally be substituted by C-C-alkoxy, and, heterocyclyl may optionally be substituted by oxo,'}], 'where C-C-alkyl may optionally be substituted by hydroxyl, cyano, amino, C-C-alkylaminocarbonylamino, C-C-alkylaminocarboxyl, heterocyclyl or aryl,'}, 'Ris hydrogen, fluorine, chlorine, bromine, cyano, amino, trifluoromethyl, trifluoromethoxy, C-C-alkyl, C-C-alkylcarbonyl, C-C-alkylamino, formyl, hydroxycarbonyl, C-C-alkoxy, C-C-alkoxycarbonyl, C-C-alkylthio, C-C-alkylcarbonylamino, C-C-alkylaminocarbonyl, C-C-alkylsulphonylamino, C-C-cycloalkylcarbonylamino, C-C-cycloalkylaminocarbonyl, pyrrolyl, C-C-alkylaminocarbonylamino, heterocyclylcarbonyl, heterocyclylcarbonylamino, heteroarylcarbonylamino, hydroxyl, phenyl or heterocyclyl,'}A is oxygen or sulphur;{'sub': 1', '4, 'the ring B is benzo or pyrido, each of which are optionally substituted by radicals from the series halogen, cyano, trifluoromethyl, trifluoromethoxy and C-C-alkyl,'}and{'sub': 1', '4', '1', '4, 'E is C≡C, arylene and heteroarylene, where arylene and heteroarylene may be substituted by radicals from the series halogen, cyano, trifluoromethyl, ...
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