Способ получения ненасыщенных производных 7-ациламидо-3-цефем-4-карбоновой кислоты или их сложных эфиров или их солей с щелочными металлами

Способ получения ненасыщенных производных 7-ациламидо-3-цефем4-карбоновой кислоты или их солей

CEPHALOSPORINS

... 1426072 7 - # - Acylaminoceph - 3 - ems BEECHAM GROUP Ltd 17 Jan 1974 [18 Jan 1973 [20 Oct 1973] 2571/73 and 49000/73 Headings C2C and C2P Novel 7-#-acylaminoceph-3-ems of the general formula wherein Py is a 2- or 3-pyridyl group (optionally quaternized), R is an acyl group and R1 is a carboxylic acid group or a pharmaceutically acceptable salt or ester derivative thereof, and pharmaceutically acceptable acid addition salts thereof are prepared (a) by reacting a 7#- amino-ceph-3-em of the general formula with the appropriate acylating agent; and (b) when R1 is a carboxylic acid group, by hydrolysing the corresponding ester; followed optionally by salification. Novel t-butyl 7#-amino-3-(2- or 3-pyridylmethyl)-3-cephem-4-carboxylate is prepared by reacting benzyl 6#-triphenylmethylamino)penicillanate with 1-bromo-3-(2- or 3-pyridyl)-prop- 2-yne hydrobromide, treating the resulting 1- (1-benzyloxycarbonyl - 2 - methyl - 1 - propenyl)- 3 - triphenylmethyl - amino - 4 - [3 ...

METHOD OF CONVERTING CEPHALOSPORIN C TO A DERIVATIVE THEREOF

... 1324419 N-haloalkanoyl derivatives of cephalosporin C ELI LILLY & CO 12 Oct 1970 [17 Dec 1969] 48320/70 Heading C2A Cephalosporin C is converted to an N-haloalkanoyl derivative of formula wherein R is an -halo or ,-dihalo-C 2 -C 4 alkanoyl group, by acylating the amino group in the adipoyl side chain with a corresponding haloalkanoyl halide or anhydride. The cephalosporin C may be treated in aqueous solution, e.g. a productive fermentation broth which preferably has been filtered and if necessary concentrated, to convert it to the said derivative which is easily extracted from the aqueous medium with a water-immiscible solvent such as ethyl acetate. The acylating agent is preferably an -halo or ,-dihaloalkanoyl chloride or mixed anhydride (e.g. acetic chloroacetic anhydride). The solvent extraction is best conducted at acid pH and immiscible solvents used include propyl or butyl acetate, nitriles and ketones. Alkyl esters may be mixed with one tenth to one volume of C 2 to C 4 alkanol.

CEPHALOSPORIN ESTERS WITH ANTIBACTERIAL ACTIVITY

... 1464330 Cephalosporins SMITHKLINE CORP 25 June 1975 [26 June 1974] 26858/75 Heading C2C Novel compounds (I) (including salts thereof) wherein: M is or indanyl; n is 0 to 4; R is hydrogen, alkyl having 1 to 8 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenyl, phen-C 1 -C 4 -alkyl, pyridyl, thienyl, or pyrrolyl; R 1 is hydrogen, methyl or ethyl; R 2 and R 3 are each hydrogen, alkyl having 1 to 6 carbon atoms, phenyl, pyridyl, or thienyl; R 4 and R 5 are each hydrogen or alkyl of 1 to 4 carbon atoms; R 6 is alkyl having 1 to 4 carbon atoms, phenyl, phen-C 1 - C 4 -alkyl, pyridyl methyl, thiadiazolyl, amino- C 1 -C 4 alkyl, C 1 -C 4 alkylamino C 1 -C 4 alkyl or indanyl; X is NH or O; and each phenyl group is unsubstituted or substituted with one or two substituents selected from alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 4 carbon atoms, hydroxy, NHR 1 , N(R 1 ) 2 , nitro, fluoro, chloro, bromo, or carboxy, are made by standard methods. The # - azidoethoxy - carbonyloxymethyl ...

3-Tetrahydrofuran and tetrohydropyrinol ephynolsporens and analogues.

B-Lactam antibiotics of formula (I) or a salt thereof: wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group;CO2R3 is a carboxy group or a .carboxylate anion, or R is a readily removable carboxy protecting group; R represents up to four substituents; X is S,SO,S02,0.or CH2; m is 1 or 2;and n is 0, useful in the treatment of bacterial infections in humans and animals.

NOVEL COMPOUNDS

NOVEL COMPOUNDS

PROCEDURE FOR MANUFACTURING NEW DERIVATIVES of the 7-ACYLAMIDO-3-CEPHEM-4-CARBONSAEURE AND YOUR SALTS

VERFAHREN ZUM HERSTELLEN VON NEUEN HETEROMONO- CYCLISCHEN UND HETEROBICYCLISCHEN DERIVATEN UNGESAETTIGTER 7-ACYLAMIDO-3-CEPHEM-4-CARBON- SAEUREN, IHREN SALZEN UND ISOMREN

Oxime derivatives of cephalosporanic structure and compounds for their preparation

7-ALPHA-METHOXYCEPHALOSPORIN DERIVATIVES

UNSATURATED DERIVATIVES OF 7-ACYLAMIDO-3-CEPHEM-4- CARBOXYLIC ACID AND PROCESS FOR THEIR PREPARATION

This invention relates to compounds of the general formula I (I) wherein Z is cyano or carbamoyl; A is trans -CH=CH, cis -CH=CH or -C?C-; B is -O-?-CH3 or -S-Het wherein Het is one of the following groups , wherein R is hydrogen or methyl, or wherein R1 and R2 are independently selected from the group consisting of hydrogen and methyl; X is a free or esterified carboxy group, and pharmaceutically and veterinarily acceptable salts thereof. These compounds possess a high antibacterial activity against both Gram-positive and Gram-negative bacteria and are therefore useful in the treatment of infections caused by said microorganisms. This invention also provides a process for the preparation of these useful compounds.

CEPHAMYCINS

HETEROMONOCYCLIC AND HETEROBICYCLIC DERIVATIVES OF UNSATURATED 7-ACYLAMIDO-3-CEPHEM-4-CARBOXYLIC ACID AND PROCESS FOR THEIR PREPARATION

VERFAHREN ZUR UMWANDLUNG VON CEPHALOSPORIN C ODER DESSEN CARBONSAEURESALZ IN EIN IN ORGANISCHEN LOESUNGSMITTELN LOESLICHES DERIVAT.

PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORANSAEUREDERIVATEN.

PROCEDURE FOR the PRODUCTION 7-METHOXYCEPHALOSPORINDERIVATE.

PROCEDURE FOR the PRODUCTION OF INSATIATED DERIVATIVES of the 7-ACYLAMIDO-3-CEPHEM-4-CARBONSAEURE.

PROCEDURE FOR the PRODUCTION OF INSATIATED DERIVATIVES of the 7-ACYLAMIDO-3-CEPHEM-4-CARBONSAEURE.

PROCEDURE FOR THE PRODUCTION OF CEPHAMYCINEN.

PROCEDURE FOR THE PRODUCTION OF 3 (MORPHOLINOALKOXYIMINOMETHYL) - CEPHEMVERBINDUNGEN.

BICYCLI HETERO DERIVATIVES OF INSATIATED ONES 7-ACYLAMIDO-3-CEPHEM-4-CARBONSAEUREN, AS WELL AS ITS PRODUCTION AND YOUR USE FOR the PRODUCTION of PHARMACEUTICAL PREPARATIONS.

THE 7ALPHA-TO-[...] DERIVATIVES AND PROCESSES FOR THEIR PREPARATION.

2-ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ЦЕФЕМА

Изобретение относится к соединениям, представленным формулами ниже, и их фармацевтически приемлемым солям, к фармацевтической композиции, содержащей такое соединение, а также к применению указанных соединений в антибактериальной терапии, в частности в терапии инфекции, вызываемой грамотрицательными и/или грамположительными бактериями.

2 SUBSTITUTED CEPHEM COMPOUNDS

DERIVES From the 7A-METHOXYCEPHALOSPORINE, ITS MANUFACTORING PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THIS DRIFT

CEPHALOSPORIN C SOLUBILIZATION PROCESS

NEW CEPHAMYCINES, THEIR PREPARATION AND THEIR APPLICATION

DERIVED HETEROBICYCLIQUES FROM the UNSATURATED 7-ACYLAMIDO-3-CEPHEM-4-CARBOXYLIC ACID, PROCEEDED OF PREPARATION FROM THOSE AND USE INTO THERAPEUTIC

Способ получения ненасыщенных производных 7-ациламидо-3-цефем-4-карбоновой кислоты или их сложных эфиров или их солей с щелочными металлами

7-METHOXY-CYCLOHEXADIENYLUREIDOCEPHALOSPORINE

CEPHALOSPORINE AND YOUR HOMOLOGOUS ONES, PREPARATIONS AND PHARMAZEUTSICHE PREPARATIONS

PROCEDURE FOR MANUFACTURING NEW HETERO MONO CYCLI AND HETEROBICYCLI DERIVATIVES of INSATIATED ONES 7-ACYLAMIDO-3-CEPHEM-4-CARBON SAEUREN, YOUR SALTS AND ISOMERS

VINYLPYRROLIDINON CEPHALOSPORIN DERIVATIVES

CEPHALOSPORINDERIVATE, YOUR PRODUCTION AND APPLICATION.

PROCEDURE FOR MANUFACTURING NEW HETERO MONO CYCLI AND HETEROBICYCLI DERIVATIVES of INSATIATED ONES 7-ACYLAMIDO-3-CEPHEM-4-CARBON ACIDS, YOUR SALTS AND ISOMREN

BETA-LACTAM DERIVATIVES

CEPHALOSPORINS

CEPHALOSPORINS AND HOMOLOGUES PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS

... ▓▓ B-Lactam antibiotics of formula (I) or a salt thereof,▓wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group;▓ CO2R3 is a carboxy group or a carboxylate anion, or R3is a readily▓removable carboxy protecting group; R4 represents up to four▓substituents; X is S, SO, SO2, O or CH2; m is 1 0r 2; and n is 0,▓useful in the treatment of bacterial infections in humans and▓animals.▓ ...

OXIME DERIVATIVES OF CEPHALOSPORANIC STRUCTURE AND COMPOUNDS FOR THEIR PREPARATION

... : OXIME DERIVATIVES OF CEPHALOSPORANIC STRUCTURE AND COMPOUNDS FOR THEIR PREPARATION The invention relates to oxime derivatives of cephalosporanic structure, possessing antibacterial activity.

2 - SUBSTITUTED CEPHEM

7- METHOXYCEPHALOSPORINE, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATIONS

BROAD-SPECTRUM CEPHEM COMPOUNDS

Compounds represented by the general formula (I), esters of the compounds, derivatives thereof obtained through protection of amino on the 7-position thiazole ring, or pharmaceutically acceptable salts or solvates of them: (I) wherein T is S, SO, or O; X is halogeno, CN, carbamoyl which may be substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono-lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); and Z+ is an optionally substituted nitrogenous heterocyclic group having a cationic group.

ОКСИМНЫЕ ПРОИЗВОДНЫЕ С ЦЕФАЛОСПОРАНОВОЙ СТРУКТУРОЙ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ

Изобретение относится к оксимным производным с цефалоспорановой структурой, обладающим антибактериальной активностью.

Способ получения производных цефалоспорина C

7-METHOXYCEPHALOSPORINDERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

CEPHALOSPORINE UND IHRE HOMOLOGEN, ZUBEREITUNGEN UND PHARMAZEUTSICHE PRÄPARATE

BETA-LACTAM DERIVATIVES

VERFAHREN ZUM HERSTELLEN VON NEUEN DERIVATEN DER 7-ACYLAMIDO-3-CEPHEM-4-CARBONSAEURE UND IHREN SALZEN

2 substituted cephem compounds

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

COMPOSITIONS PROVIDING ENHANCED ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE BACTERIA AND USE THEREOF

A method of inhibiting, reducing growth of or destroying gram positive bacteria comprising contacting the gram positive bacteria with an effective amount of a 2-(substituted-amino)-imidazole compound and with an additional antibacterial compound separately, simultaneously, or sequentially, whereby the two compounds provide an antibiotic potentiation effect against the gram-positive bacteria. The additional antibacterial compound may comprise penicillin, daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).

BETA-LACTAM DERIVATIVES

... 2071885 9109036 PCTABS00005 Cephalosporins of formula (I), wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for their preparation starting from the corresponding 4-acyl cephem are also provided.

CEPHALOSPORINS AND HOMOLOGUES, PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS

... 2087967 9201696 PCTABS00010 .beta.-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 represents up to four substituents; X is S, SO, SO2, O or CH2; m is 1 or 2; and n is 0, useful in the treatment of bacterial infections in humans and animals.

METHOD OF PREPARATION OF DERIVED From ACID 7-AMINOCEPHALOSPORANIQUE

CEPHALOSPORIN C SOLUBILIZATION PROCESS

NEWS SALTS IN THE PREPARATION OF CEPHALOSPORIN ANTIBIOTICS

The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n = 0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II). © KIPO & WIPO 2007 ...

CEPHALOSPORINS AND HOMOLOGUES, PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS

... beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 represents up to four substituents; X is S, SO, SO2, O or CH2; m is 1 or 2; and n is 0, useful in the treatment of bacterial infections in humans and animals.

HETEROBICYCLIC DERIVATIVES OF UNSATURATED 7-ACYLAMIDO-3-CEPHEM-4-CAROXYLIC ACID

A 7a-methoxycephalosporin derivative and process for producing the same

A 7 alpha -methoxycephalosporin derivative represented by the formula (I): wherein R1 represents a heterocyclic ring or an -S- heterocyclic ring; R2 represents a hydrogen atom, a carboxy group or a -COOR5 group wherein R5 represents a C1-6 alkyl group, a dialkylamino-C1-6 alkyl group or a group wherein R6 represents a C1-6 alkyl group, a C1-6 acyl group or a (C1-6 alkoxy) carbonyl group and Y represents a hydrogen atom or a C1-6 alkyl group; R3 represents a hydrogen atom, a carbamoyl group or a C1-6 acyl group; R4 represents a hydrogen atom, a C1-6 alkyl group, a dialkylamino-C1-6 alkyl group or a group wherein R6 and Y are defined as above; A and B, which may be the same or different, each represents a straight chain or branched chain alkylene group having 1 to 5 carbon atoms; and x represents 0 or 1; or a pharmaceutically acceptable salt thereof.

BETA LACTAM DERIVATIVES.

PROCEDURE FOR MANUFACTURING NEW DERIVATIVES of the 7-ACYLAMIDO-3-CEPHEM-4-CARBONSAEURE AND YOUR SALTS

Procedure for the production of new Cephalosporin C-derivatives soluble in organic solvents

CEPHALOSPORINS

3-%MORPHOLINOALKOXYIMINOMETHYL<CEPHEM COMPOUNDS

7-ALPHA METHOXYCEPHALOSPORIN DERIVATIVES

UNSATURATED DERIVATIVES OF 7-ACYLAMIDO-3-CEPHEM-3-CARBOXYLIC ACID

PROCESS FOR PREPARING 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES

PROCESS FOR PREPARING 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES 7-Aminocephalosporanic acid derivatives represented by the general formula (III), (III) wherein X is hydrogen, hydroxyl, acetoxy or a nucleophilic residue, which are useful as a starting material for the synthesis of cephalosporin type antibiotics low in toxicity and broad in pharmacological effect can be easily prepared by allowing to react cephalosporin C or its derivative represented by the general formula (I), (I) wherein X is as defined above, or a salt thereof with an .alpha.-keto derivative represented by the general formula (II), (II) . wherein R1 is carboxyl, aroyl or amide when R2 is hydrogen, and is carboxy! when R2 is alkyl or aryl, or its salt. In this case, the yield of the 7aminocephalosporanic acid derivatives can be remarkably improved by carrying out the reaction in the presence of hydrogen peroxide. The yield can be further improved by adding thiosulfuric acid or a salt thereof after the completion of the reaction ...

NEW UNSATURATED Of ACIDS 7-ACYLAMIDO-3-CEPHEM-4-CARBOXYLIQUES, USEFUL DERIVATIVES IN PARTICULAR LIKE AGENTS ANTIBACTERIENS, AND THEIR METHOD OF PREPARATION

DERIVED HETEROMONOCYCLIQUES ETHETEROBICYCLIQUES FROM THE ACID 7 UNSATURATED ACTYLAMIDO-3-CEPHEM-4-CARBOXYLIQUE, PROCEEDED OF PREPARATION FROM THOSE, AND USE INTO THERAPEUTIC

DERIVED HETEROBICYCLIQUES FROM the UNSATURATED 7-ACYLAMIDO-3-CEPHEM-4-CARBOXYLIC ACID, PROCEEDED OF PREPARATION FROM THOSE AND USE INTO THERAPEUTIC

2 IT CEPHEM COMPOUNDS SUBSTITUTED AND PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPOUNDS 11 2015 009460 - 0 29/10/2013 BRR

PREPARATION DE DERIVES DE L'ACIDE 7-AMINOCEPHALOSPORANIQUE

beta -lactam derivatives of the cephem sulphone type

PCT No. PCT/EP90/02189 Sec. 371 Date Jun. 12, 1992 Sec. 102(e) Date Jun. 12, 1992 PCT Filed Dec. 14, 1990 PCT Pub. No. WO91/09036 PCT Pub. Date Jun. 27, 1991.Cephalosporins of the formula (I): (I) wherein m is one or two; n is zero, one or two; A and B are organic residues; and R1 and R2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for their preparation starting from the corresponding 4-acyl cephem are also provided.

Способ получения ненасыщенных произ-ВОдНыХ 7-АцилАМидО-3-цЕфЕМ-4-КАРбОНОВОйКиСлОТы или иХ СОлЕй

7A - METHOXYSEPHALOSPORIN DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

Cephalosporins and homologues, preparations and pharmaceutical compositions

CEPHALOSPORIN DERIVATIVES, THEIR PRODUCTION AND THEIR USES

The invention relates to novel, protected forms of Cephalosporin C and related 7-aminoadipin-amidocephalosporanic acids, their production and their use in producing corresponding 7-aminocephalosporanic acid derivatives by deacylation, ...

PROCESS FOR PREPARING 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES

DERIVES From the 7A-METHOXYCEPHALOSPORINE, ITS MANUFACTORING PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THIS DRIFT

2 치환된 세펨 화합물

... 본 발명의 하기 화학식 I의 화합물은 광범위한 항미생물 스펙트럼을 가지며, 특히 베타-락타마제 생산 그람 음성 박테리아에 대한 강력한 항미생물 활성을 나타내는 2-치환된 세펨 화합물 및 그를 포함하는 제약 조성물에 관한 것이다. <화학식 I> ...

CEPHALOSPORINS AND HOMOLOGUES, PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS

... beta-Lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group; R4 represents up to four substituents; X is S, SO, SO2, O or CH2; m is 1 or 2; and n is 0, useful in the treatment of bacterial infections in humans and animals.

CEPHALOSPORIN C SOLUBILIZATION PROCESS

СОЕДИНЕНИЕ ЦЕФЕМА И ЕГО ФАРМАЦЕВТИЧЕСКИ ИЛИ ВЕТЕРИНАРНО ПРИЕМЛЕМЫЕ СОЛИ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

Сущность изобретения: Соединение цефема общей формулы (1), где m = 1 или 2, n = 0,1 или 2, А - низший алкил, нефтил или необязательно замещенный фенил. В - низший алкил, карбокси/низший/ алкил, защищенный карбокси/низший/алкил, фенил или гетерил; R1 - галоген, низший алкоксил, R2 - низший алкил, низший алканоилоксиметил или группа -CH2 -S-Het, где Het - гетерил; и его фармацевтически или ветеринарно приемлемые соли. Соединение общей формулы (I) получают взаимодействием соединения общей формулы (II) с галогенирующим агентом. Полученное при этом соединение общей формулы (III) подвергают взаимодействию с соединением MS(O)nB, где М - водород или катион металла. Соединение общей формулы (I) получают взаимодействием соединения общей формулы (II) с соединением LS(O)nB, где L - уходящая группа. Взаимодействие проводят в присутствии органического или неорганического основания в апротонном полярном или неполярном растворителе при -60 - +40oC. 3 с. и 2 з. п. ф-лы. 4 табл. а ...

Vinylpyrrolidone cephalosporin derivatives

Oxime derivatives of cephalosporanic structure and compounds for their preparation

BROAD-SPECTRUM CEPHEM COMPOUNDS

Compounds represented by the general formula (I), esters of the compounds, derivatives thereof obtained through protection of amino on the 7-position thiazole ring, or pharmaceutically acceptable salts or solvates of them: (I) wherein T is S, SO, or O; X is halogeno, CN, carbamoyl which may be substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono-lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); and Z+ is an optionally substituted nitrogenous heterocyclic group having a cationic group.

3-(Morpholinoalkoxyiminomethyl)cephem compounds

CEPHALOSPORINS

2 SUBSTITUTED CEPHEM COMPOUNDS

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

Cephem compounds having broad antibacterial spectrum

A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.

HETEROCYCLIC AND HETERO DICYCLIC DERIVATIVES OF UNSATURATED 77ACYLAMIDE 33CEPHEMM44CARBOXYLATE AND PROCESS FOR PREPARING SAME

NEUE 7 BETA-ACYLAMINOCEPH-3-EM-VERBINDUNGEN SOWIE VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ALS WIRKSTOFFE ENTHALTENDE ARZNEIPRAEPARATE

7 ALPHA -METHOXYCEPHALOSPORINDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND ARZNEIMITTEL, WELCHE DIESE ENTHALTEN

PROCESS FOR PREPARING 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES

... 1494452 7 - Aminocephalosporanic acid derivatives ASAHI KASEI KOGYO KK 20 Jan 1976 [22 Jan 1975 9 July 1975 (2) 18 July 1975] 02162/76 Heading C2C A process for preparing the -ketoadipoyl-7- ACA derivative of Formula (IV) (wherein X is H, OH, acetoxy or a nucleophilic residue) and 7-aminocephalosporanic acid derivatives of Formula (III) comprises allowing cephalosporin C or its derivative of the Formula (I) or a salt thereof, to react with an -keto derivative of Formula (II) R 1 -CO-R 2 (wherein R 1 is carboxyl, aroyl or amide when R 2 is hydrogen, and is carboxyl when R 2 is alkyl or aryl, or its salt. Compound (III) is obtained selectively when the above reaction is carried out in the presence of hydrogen peroxide. Preferred -keto derivatives are glyoxalic acid, phenylglyoxal, glyoxalic acid amide, pyruvic acid, -keto-phenylacetic acid and sodium - keto-n-butanoate. Reaction may be accelerated by effecting reaction in the presence of a bivalent or trivalent metal ion or an organic base ...

UNSATURATED-THIO-DERIVATIVES OF 7-ACETAMIDO-3-CEPHEM-4-CARBOXYLIC ACID AND PROCESS FOR THEIR PREPARATION

VINYLPYRROLIDINON CEPHALOSPORIN DERIVATIVES

The present invention relates to cephalosporin derivatives of the general formula (see fig. I) where R1 is halogen, lower alkyl, phenyl, benzyl, styryl, naphthyl or heterocyclyl; the lower alkyl, phenyl, benzyl, styryl, naphthyl and heterocyclyl being optionally substituted by at least one of halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted phenyl, amino, lower alkylamino, di-lower alkylamino, carboxy, lower alkylcarboxy, carbamoyl or lower alkylcarbamoyl; R4, R5 independently are hydrogen, lower alkyl or phenyl; X is S, O, NH or CH2; n is 0, 1 or 2; m is 0 or 1; s is 0 or 1; R2 is hydrogen, hydroxy, -CH2-CONHR6, lower alkyl-Qr, cycloalkyl-Qr, lower alkoxy, lower alkenyl, cycloalkenyl-Qr, lower alkynyl, aralkyl-Qr, aryl-Qr, aryloxy, aralkoxy, a heterocyclic ring or a heterocyclyl-Qr, the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl, aryl, aryloxy, aralkoxy and the heterocyclic ...

CEPHALOSPORIN DERIVATIVES, THEIR PRODUCTION AND THEIR USES

METHOD FOR CONVERTING CEPHALOSPORIN C TO AN ORGANIC SOLVENT-SOLUBLE DERIVATIVE AND THE COMPOUND RESULTING THEREFROM