COMPOSITIONS PROVIDING ENHANCED ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE BACTERIA AND USE THEREOF

A method of inhibiting, reducing growth of or destroying gram positive bacteria comprising contacting the gram positive bacteria with an effective amount of a 2-(substituted-amino)-imidazole compound and with an additional antibacterial compound separately, simultaneously, or sequentially, whereby the two compounds provide an antibiotic potentiation effect against the gram-positive bacteria. The additional antibacterial compound may comprise penicillin, daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).