16-05-2013 дата публикации
Номер: US20130123493A1
A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof, Formula (II): Formula (I): the process comprising the reaction of a carbamate of Formula (II′): or formula (I′): with a primary or secondary amine of the formula: R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein. 3. A process according to or , wherein the compound has the Formula IIa , and wherein the carbamate of Formula II′ has a corresponding structure in which the —NR1R2 group of Formula IIa is replaced by the —C(O)O-Ph-J group of Formula II′.4. The process according to claim 3 , wherein the compound is of Formula IIa claim 3 , and wherein:{'sub': '1-4', 'R1 is selected from H and Calkyl,'}{'sub': 1-6', '3-10', '1-6', '1-6', '1-6', '3-10', '1-6', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '1-6', '1-6', '3-8, 'R2 is selected from Calkyl, aryl, heteroaryl, heterocyclyl, Ccycloalkyl, aryl Calkyl, heteroaryl Calkyl, heterocyclyl Calkyl and Ccycloalkyl Calkyl, each of which may optionally be substituted with one or more groups selected from R2a, halogen, OH, OR2a, OCOR2a, SH, SR2a, SCOR2a, NH, NHR2a, NHSONH, NHSOR2a, NR2aCOR2b, NHC(NH)NH, NHCOR2a, NR2aR2b, COR2a, CSR2a, CN, COOH, COOR2a, CONH, CONHOH, CONHR2a, CONHOR2a, C(NOH)NH, SOR2a, SOH, SONH, CONR2aR2b, SONR2aR2b, wherein R2a and R2b are independently selected from Calkyl, substituted Calkyl, aryl, heteroaryl, Ccycloalkyl and heterocyclyl, or R2a and R2b, together with the heteroatom to which they are joined, can form heterocyclyl,'}{'sub': 1-6', '1-6', '3-8', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '1-6', '1-6', '3-8, 'wherein, when the substituent of R2 is Calkyl, substituted Calkyl, aryl, heteroaryl, Ccycloalkyl, heterocyclyl or a group containing one or more of these moieties, each of these moieties may optionally be substituted with one or more groups selected from R2c, halogen, OH, OR2c, OCOR2c, SH, SR2c, SCOR2c, ...
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