СПОСОБ ПОЛУЧЕНИЯ БИС(1-ГИДРОКСИЭТАН-1,1-ДИФОСФОНАТА(1-)) МЕДИ(II) ИЗ ОТХОДОВ ПРОИЗВОДСТВА

Изобретение относится к химической технологии органических веществ, в частности к улучшенному способу получения бис(1-гидроксиэтан-1,1-дифосфоната(1-)) меди(II). Целевой бис(1-гидроксиэтан-1,1-дифосфонат(1-)) меди(II) получают кристаллизацией из водного раствора с концентрациями соли меди(II) от 0,5 до 2,0 моль/л и 1-гидроксиэтан-1,1-дифосфоновой кислоты от 2,0 до 6,0 моль/л, полученного с использованием жидких медьсодержащих отходов гальванического и радиоэлектронного производств или с использованием полупродукта производства 1-гидроксиэтан-1, 1-дифосфоновой кислоты. Технический результат - снижение себестоимости бис(1-гидроксиэтан-1,1-дифосфоната(1-)) меди(II) при сохранении его чистоты, расширение сырьевой базы для получения целевого продукта, утилизация отходов производства. 8 з.п. ф-лы, 1 табл.

КОНЪЮГАТЫ RGD-ПЕПТИДОВ И ФОТОСЕНСИБИЛИЗАТОРОВ ПОРФИРИНА ИЛИ (БАКТЕРИО)ХЛОРОФИЛЛА И ИХ ПРИМЕНЕНИЕ

Изобретение относится к фотосенсибилизаторам, а именно к конъюгату RGD-содержащего пептида или RGD-пептидомиметика и фотосенсибилизатора, выбранного из тетраарилпорфирина формулы: ! ! или хлорофилла или бактериохлорофилла формул I, II или III; ! ! ! в котором тетраарилпорфирин или указанное производное хлорофилла или бактериохлорофилла формулы I, II или III содержит, по меньшей мере, один остаток RGD-содержащего пептида или RGD-пептидомиметика. Значения М и радикалов соответствуют указанным в формуле изобретения. Также предложены фармацевтическая композиция, способ диагностики опухолей динамической флуоресцентной визуализацией, молекулярная магнитно-резонансная томография (МРТ) для диагностики опухолей и способ фотодинамической терапии опухолей. Изобретение позволяет получить конъюгат RGD-содержащего пептида или RGD-пептидомиметика и фотосенсибилизатора, который применяется в способах фотодинамической терапии и диагностики опухолей. 6 н. и 17 з.п. ф-лы, 75 ил., 43 пр., 5 табл.

Способ получения термоактивированного металлоорганического координационного полимера и способ получения композитного нанопористого адсорбента на его основе

Изобретение относится к технологии синтеза и активации металлорганических полимеров для создания функциональных блочных материалов - адсорбентов, а именно к способу получения термоактивированного металлорганического координационного полимера Cu-ВТС. Способ включает взаимодействие при перемешивании раствора нитрата меди Cu (II) с раствором 1,3,5 -бензолтрикарбоновой кислоты, с использованием в качестве растворителя - N,N'-диметилформамида, с образованием пористой структуры, и последующей активацией, при этом активацию проводят комбинированным способом, включающим промывку подогретым до температуры 40-60°С органическим растворителем, сушку при температуре 90-120°С, термовакуумную активацию при температурах 110-200°С. Также предложены термоактивированный металлорганический координационный полимер Cu-ВТС, способы получения композитного нанопористого адсорбента и композитный нанопористый адсорбент. Техническим результатом изобретения является улучшение адсорбционных свойств металлорганического ...

КАТАЛИЗАТОР ДЛЯ ПОЛУЧЕНИЯ 3-(3-ФЕНИЛПРОП-2-ИН-1-ИЛ)-1,3-ОКСАЗОЛИДИНА

Изобретение относится к катализатору для получения 3-(3-фенилпроп-2-ин-1-ил)-1,3-оксазолидина, который может найти применение в синтезе биологически активных соединений. В качестве катализатора предлагается новый хелатный S,S-комплекс дихлорида димеди(I) 1,2-бис[(3,5-диметилизоксазол-4-ил)метилсульфанил]этана. Технический результат заключается в получении 3-(3-фенилпроп-2-ин-1-ил)-1,3-оксазолидин с выходами 75-98%. 1 табл., 1 пр.

СПОСОБ ПОЛУЧЕНИЯ МЕТАЛЛСОДЕРЖАЩИХ ПРОИЗВОДНЫХ БАКТЕРИОХЛОРОФИЛЛА, НОВЫЕ МЕТАЛЛИРОВАННЫЕ ПРОИЗВОДНЫЕ БАКТЕРИОХЛОРОФИЛЛА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ

Новые способы получения металлированных производных [M]-бактериохлорофилла общей формулы I, где R1 представляет собой С1-С25 углеводородный остаток; R2 представляет собой Н, ОН или COOR5, где R5 представляет собой С1-С12 алкил или С3-С12 циклоалкил; R3 представляет собой Н, ОН или С1 -С12 алкил или алкокоси; каждый R4 является независимо выбранным из группы, включающей винил, этил, ацетил, 1-гидроксиэтил и их простые и сложные эфиры; М представляет собой металл с ионным радиусом, меньшим, чем имеющийся у Cd (r≅95 пм), причем указанный металл выбран из группы, состоящей из двухвалентного металла, выбранного из группы, включающей Pd, Co, Ni, Cu, Zn и Mn, новые металлированные производные [M]-бактериохлорофилла и фармацевтическая композиция, их содержащая. Металлированные производные бактериохлорофилла могут применяться в методах фотодинамической терапии и фотодинамического уничтожения вирусов и микроорганизмов. 5 с. и 9 з.п. ф-лы, 1 табл., 2 ил.

ТЕТРА-(5-АЦЕТИЛАМИНО-7-ГЕПТИЛОКСИ)АНТРАХИНОНОПОРФИРАЗИНЫ МЕДИ И КОБАЛЬТА

Изобретение относится к тетра-(5-ацетиламино-7-гептилокси)антрахинонопорфиразинам меди и кобальта формулы ! ! Полученные соединения могут быть использованы в качестве красителей и катализаторов. 5 ил.

ТЕТРА-(5-АЦЕТИЛАМИНО-7-ГИДРОКСИ)-АНТРАХИНОНОПОРФИРАЗИНЫ МЕДИ И КОБАЛЬТА

Изобретение относится к тетра-(5-ацетиламино-7-гидрокси)антрахинонопорфиразинам меди и кобальта формулы ! ! Полученные соединения могут быть использованы в качестве красителей и катализаторов. 7 ил.

СРЕДСТВО, ОБЛАДАЮЩЕЕ АНТИБАКТЕРИАЛЬНОЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ КУЛЬТУРЫ КЛЕТОК ESCHERICHIA COLI

Изобретение относится к фармакологии, в частности, к применению комплексных соединений меди(II) на основе арилметиленбиспиран-2-онов указанной ниже формулы, в которой при n = 4 R=H (1) или R=3-NO2(2), в качестве антибактериального средства в отношении культуры клеток Escherichia coli K-12. Изобретение направлено на расширение арсенала средств, обладающих антибактериальным действием в отношении культуры клеток Escherichia coli K-12. 2 ил., 1 табл., 2 пр.

1-АЦЕТИЛ-5,10-ДИОКСИ-5,10-ДИГИДРО-2Н-АНТРА[2,3-D][1,2,3]ТРИАЗОЛ-7,8-ДИКАРБОНОВАЯ КИСЛОТА

Описывается новое соединение - 1-ацетил-5,10-диокси-5,10-дигидро-2Н-антра[2,3-D][1,2,3]триазол-7,8-дикарбоновая кислота формулы ! ! которое может быть использовано в качестве исходного соединения для синтеза металлокомплексов тетра[4,5]([6,7]1-ацетил-2Н-нафто[2,3-D][1,2,3]триазол-5,8-дион)фталоцианина; последние могут быть использованы в качестве красителей или катализаторов. 5 ил.

ТЕТРА[4,5]([6,7]1-АЦЕТИЛ-2Н-НАФТО[2,3-D][1,2,3]ТРИАЗОЛ-5,8-ДИОН)ФТАЛОЦИАНИНЫ МЕДИ И КОБАЛЬТА

Изобретение относится к тетра[4,5]([6,7]1-ацетил-2Н-нафто[2,3-D][1,2,3]триазол-5,8-дион)фталоцианинам меди и кобальта формулы ! ! где М - Cu, Со. Технический результат - изобретение позволяет получить новые производные фталоцианинов, которые могут быть использованы в качестве красителей, а также в качестве катализаторов различных процессов. 5 фиг., 1 ил.

СПОСОБ ПОЛУЧЕНИЯ ФТАЛОЦИАНИНА МЕДИ

Использование: в качестве химического реагента, красящего пигмента активного компонента катализатора окислительно-восстановительных реакций. Сущность изобретения: продукт фталоцианин меди. Проведение синтеза фталоцианина меди ведут под давлением до 1,5 МПа при 160 200°С, молярном соотношении реагентов фталевый ангидрид, источник меди (хлорид одно-или двухвалентной меди, сульфат меди), мочевина и катализатор (аммоний молибденовокислый, титан четыреххлористый и борная кислота), равном 1 (0,25 0,3) (2,5 3,5) (0,1 0,15), в присутствии гидрофобного растворителя минерального масла в количестве 300 800 мас.ч. растворителя на 592 мас.ч.фталевого ангидрида. 4 табл.

Ди[(фуран-3-карбоксилато-О)-(2,9-диметил-1,10-фенантролин-N,N')-медь(II)], обладающий антипролиферативной и антимикобактериальной активностью

Изобретение относится к координационным соединениям металлов. Предложено координационное соединение ди[(фуран-3-карбоксилато-O)-(2,9-диметил-1,10-фенантролин-N,N')-медь(II)] формулы обладающее антипролиферативным действием по отношению к раковым клеткам и антимикобактериальной активностью. Предложенное соединение может быть использовано в химиотерапии рака и туберкулеза. 3 ил., 2 табл., 5 пр.

МЕТАЛЛОКОМПЛЕКСЫ ТЕТРА-6-КАРБОКСИ-АНТРАХИНОНОПОРФИРАЗИНА

Изобретение касается новых производных металлопорфиразинов общей формулы I, где М=Cu, Со, которые могут быть использованы в качестве красителей, катализаторов различных процессов, материалов чувствительных элементов датчиков газов. 5 ил.

СПОСОБ ОБНАРУЖЕНИЯ И ЛЕЧЕНИЯ РАКА ЛЕГКИХ

Изобретение может быть использовано в медицине, в частности в онкологии для обнаружения и лечения рака легких. Способ высококонтрастный для быстрого обнаружения наличия злокачественных клеток in vitro и селективного облучения малых неясных злокачественных опухолевых масс в легких пациента. Исследуют биологический материал на наличие флуоресцирующих клеток, при этом получают одноклеточную суспензию клеток легких, обрабатывают ее 5,10,15,20-тетракис(4-карбоксифенил)порфином в течение промежутка времени, достаточного для захвата существенного его количества злокачественными клетками легких, выдерживают обработанную клеточную суспензию под ультрафиолетовым облучением и обнаруживают злокачественные клетки легких по наличию флуоресцирующих клеток в ней. Для лечения в части второго способа вводят в организм радиоизотоп, и производное порфирина, а именно комплекс67Cu 5,10,15,20-тетракис-(4-карбоксифенил)порфина. 8 с. и 12 з.п.ф-лы, 1 ил.

СПОСОБ ПОЛУЧЕНИЯ МЕТАЛЛФТАЛОЦИАНИНОВ

Сущность: получение фталоцианина металла (Cu, Ni, Zn) улучшенным способом. Реагент 1: фталевый ангидрид. Реагент 2: мочевина. Реагент 3: медный купорос или медь-цинк, или цинксодержащий гальванический шлам. Условия процесса: сплавление реагентов 1, 2 и 3 с предварительной обработкой массы водой в количестве 10-30 мас.%, а для связывания аммиака, выделяющегося в процессе синтеза, отходящие газы пропускают через барбатер с водной суспензией фталевого ангидрида при 20-60oC. 3 табл.

СПОСОБ ПОЛУЧЕНИЯ ТОНКОКРИСТАЛЛИЧЕСКОГО ФТАЛОЦИАНИНА МЕДИ

... (57) Изобретение относится к способам получения фталоцианина меди (PcCu), который может использоваться как краситель6 сенсор, компонент фоточувствительных слоев. Цель изобретения - упрощение процесса, получение PcCu в тонкокристаллической форме. Цель достигается тем, что синтез PcCu ведут при температуре 20 - 40oC в N,N-диметилформамиде взаимодействием 1,3-дииминоизоиндолина (ДИИ) с ультрадисперсным порошком меди (УДП Cu) с удельной поверхностью более 30 м2/г, полученный электрическим взрывом проводника в атмосфере азота, причем смешивание УДП Cu и ДИИ осуществляют в сухом виде.

Способ получения водорастворимого металлокомплекса хлорина е6 с медью

Настоящее изобретение относится к химико-фармацевтической промышленности, а именно к разработке новых способов получения фотосенсибилизаторов. Предложен способ получения медного металлокомплекса хлорина е6 со структурной формулой (1), включающий: реакцию N-метил-D-глюкамина и водорастворимой соли меди в водном растворе с получением соединения со структурной формулой (2), реакцию металлирования соединения со структурной формулой (3) соединением со структурной формулой (2) в водном растворе с последующим инкубированием раствора при температуре 37-60°С в течение 10-30 минут. 4 з.п. ф-лы, 1 пр. (1) (2) (3) ...

СРЕДСТВО ДЛЯ ЗАЩИТЫ ОТ БИОРАЗРУШЕНИЙ ДРЕВЕСНЫХ И ЛАКОКРАСОЧНЫХ МАТЕРИАЛОВ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И СПОСОБ ЗАЩИТЫ ОТ БИОРАЗРУШЕНИЙ ДРЕВЕСНЫХ МАТЕРИАЛОВ

Описывается средство для защиты от биоповреждений древесных и лакокрасочных материалов, содержащее эффективное количество трикапролактамо-медь (II) дихлорид моногидрата, предлагается также усовершенствованный способ его получения в виде вододиспергируемых гранул и способ защиты от биоразрушений древесных материалов. Технический результат - увеличение эффективности действия, расширение спектра действия или усиление проникающей способности. 4 с. и 1 з.п.ф-лы, 7 табл.

МЕДЬ(1) ОРГАНИЧЕСКИЕ СОЕДИНЕНИЯ И СПОСОБ ОСАЖДЕНИЯ МЕДНОЙ ПЛЕНКИ С ИХ ИСПОЛЬЗОВАНИЕМ

... 1. Медь(I)органическое соединение формулы (I): в котором R1, R2 и R3 каждый независимо представляют собой C1-8 алкильную, C1-8 алкокси, арильную или арилокси группу, R4 и R5 каждый независимо представляют собой водород, фтор, CnF2n+1 или CnH2n+1 группу, n представляет собой целое число в диапазоне от 1 до 6, R6 представляет собой водород, фтор или C1-4 алкильную группу, и m равно 1 или 2, если m равно 1, C≡C представляет собой C≡C и если m равно 2, C≡C представляет собой С= С. 2. Соединение по п. 1, которое выбирают из соединений следующих формул 3. Способ осаждения медной пленки на подложке, который включает испарение соединения, указанного в п. 1, и введения полученных паров в контакт с подложкой.

Монопротонированный калий серинат-фолинат меди (II), проявляющий противовоспалительную и анальгетическую активность

Монопротонированный калий серинат-фолинат меди (II) формулы проявляющий противовоспалительную или анальгетическую активность.

СПОСОБ ПОЛУЧЕНИЯ ФУНГИЦИДА

Способ получения фунгицида взаимодействием азотсодержащего гетероциклического соединения с хлоридом меди в среде абсолютного спирта, отличающийся тем, что, с целью улучшения качества целевого продукта, в качестве азотсодержащего соединения используют 2-иминофенил-6H-1,3,4-тиадиазин-5-он и обрабатывают хлоридом меди в эквимольном соотношении при кипении реакционной массы.

СПОСОБ ПОЛУЧЕНИЯ МИКРОПОРИСТОГО ТРИМЕЗИАТА МЕДИ(II)

Изобретение относится к области химии и химической технологии, а именно к координационной и синтетической химии металл-органических координационных полимеров, обладающих сорбционной ёмкостью, в частности к способу получения микропористого тримезиата меди(II), включающему этапы, на которых в этиловом спирте растворяют тримезиновую кислоту и добавляют водный раствор соли меди(II) с получением смеси, в которой следующее соотношение компонентов, масс.%: 50–80% спирта, 5–10% тримезиновой кислоты, 10–20% соли меди, вода — остальное, причем смесь нагревают при 20–100°C в течение 0,5–5 часов с периодическим добавлением по каплям 0,5–2%-ого раствора щелочного агента или добавлением щелочного агента в количестве от 0,5 до 2 мольных частей на каждую мольную часть соли меди, выделяют осадок, который охлаждают до 20-30°C, очищают последовательной обработкой этанолом и дистиллированной водой или водным раствором этанола с концентрацией 10–30% и высушивают на воздухе при 70-80°C до появления у порошка ...

МЕТАЛЛОКОМПЛЕКСЫ ТЕТРА-(6-БРОМ-7-ГИДРОКСИ) АНТРАХИНОНОПОРФИРАЗИНА

Изобретение относится к новым производным металлопорфиразина формулы I, которые могут быть использованы в качестве красителей, катализаторов различных процессов, материалов чувствительных элементов датчиков газов. Изобретение позволяет получить соединения обладающие красящими свойствами. 5 ил. 5493 ...

Способ получения аланината меди (II) в присутствии цинка

БИЯДЕРНЫЕ КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ БИОЛОГИЧЕСКИ АКТИВНЫХ D-ЭЛЕМЕНТОВ С АЛИФАТИЧЕСКИМИ ТИОЛАМИ КАК СРЕДСТВА ПОВЫШЕНИЯ ЭФФЕКТИВНОСТИ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ

... 1. Соединение общей формулы ! ! и его фармацевтически приемлемые соли и сольваты, ! где М обозначает одинаковые или разные атомы металла, выбранные из группы, включающей в себя: Pd, Fe, Mn, Co, Ni, Cu, Zn или Мо; ! R1 и R2 независимо друг от друга обозначают водород, амино, гидрокси, окси, карбокси, циано, С1-12алкил, С2-12алкенил, С2-12алкинил, С1-12алкокси, C1-12алкиламино, С1-12алкоксикарбонил, С1-12алкиламидо, ариламидо, причем алкильные группировки, входящие в состав указанных заместителей, могут быть, в свою очередь, замещены одной или более чем одной из следующих групп: гидрокси, окси, карбокси, амино или амидо; ! N∩N - лиганд или лиганды, содержащие один или несколько донорных алифатических или ароматических атомов азота и занимающие цис-положение у атомов металлов (М). ! 2. Соединение по п.1, характеризующееся тем, что оно позволяет (при условии их применения в малых и ультрамалых количествах) ускорять процесс гомогенного селективного, «мягкого» окисления тиольных групп тиоаминокислот ...

Способ получения аминокарбонатов переходных металлов

Хлоро-(хлоро[(S-метилизотиосемикарбазонато-анилида пировиноградной кислоты(-1)-0,N @ , N @ )медь (П)] N @ )медь(1) гемиметилат

Изобретение касается медьоргани- ческих координационных веществ, в частности хлоро-| хлоро (S-метилизо- тиосемикарбозонато-анилида пирозино- .градной кислоты (-1)-0, N ,N) медь (I-t). , N) медь (I) гемиметилата, который может быть использован как катализатор в электрохимических процес: сах. Цель - создание новой биядерной координационной структуры разнова- лентной меди и 8-алкш1тиосемикарба- зонов. Синтез нового вещества ведут реакцией в метаноле дигидрата CuCl и гидразона (эквивалентньте соотноше ния) с последующим вьщелением jcpa- сталлов желто-зеленого цвета (игольчатый габитус) . Монокристаллы при-:, надлежат моноклинной сингонии и характеризуются следующими параметра.ми элементарной ячейки: od 1Д,213(9)А, Ь 15,050(17)А 5 с 17,321(9)1; У 112,4(5)А: V 3425(5)А, np.rij. Р .2,/b, причем в ячейке содержатся два кристаллографически нeзaвиcи ьк. комплекса, совпадающих по строению, t брутто-ф-лой. . (С„Н,з , Н45,)-СНзОН.и структурой: О (Л С1 о-CU--NH .A Hf, Ju Cl SCH, 1/2 СНчОН 4; vj со со ...

Комплексное соединение меди (П) с тиосемикарбазоновым производным стабильного нитроксильного радикала имидазолина, проявляющие противоопухолевую активность

Комплексное соединение медч (II) с тиосемикарбазоновым производным стабильного нитроксильнрго радикала имидазолина общей формулы H2N ( ;CU-H,O Н )J С1 ЩС V . проявляющее противоопухолевую активность .. .

Способ получения комплексов медьорганических соединений с соединениями трехвалентного фосфора

Способ получения моноэтаноламинатов меди (II)

Изобретение касается медных комплексных соединений, в частности получения моноэтаноламинатов меди (II) общей Ф-лы Си - (МЭА)Х(ПНЭА)г, где X - хлор-, бром,иод, СНт,С(0)0 или Си (МЭА)Х(НМЭА), где X NOJ, -N-C-S- и МЭА - анион моноэтанол- амина, которые могут найти применение в сельском хозяйстве и медицине в качестве биологически активных соединений . Цель - увеличение выхода целевых продуктов и упрощение процесса . Последний ведут нагреванием металлической меди с соответствующей солью аммония при молярном соотношении 1:(1-1,7) в моноэтанолами- не при нагревании до 50°С. Выходы целевых продуктов составляют 89-95%.

Способ получения виниловых эфиров медных (си + ) производных триазеноспиртов

Диацидо-бис/диметиламино/-изопропанолмель/п/ в качестве ускорителя холодного отверждения полиэфирных смол

Способ получения тиокарбамидного комплекса двухзамещенного фосфата меди

Способ получения медных комплексов диимидов аминокислот

Способ получения комплексной соли диглицината фосфата меди

CПOCOБ ПOЛУЧEHИЯ ДИ-2-ЭTИЛГEKCИЛФOCФATOB METAЛЛOB

Способ получения координационного соединения хлорида меди и анилина

Изобретение относится к коорди- национным соединениям металлов, в частности к координационному соединению хлорида меди и анилина (МЛ), которое может быть использовано как регулятор влажности дисперсных алюмо- силикатных систем, Повьппение качества и выхода МА достигается использованием исходных реагентов в определенном соотношении. Получение МА ведут из хлорида меди и анилина в виде 1-3,4%-ного водного раствора при их молярном соотношении 1,3-1,5:1,7- 2,0 в среде растворителя. МА представляет собой мелкокристаллический черньй продукт, не растворимый в- воде и органических растворителях, устойчивый на воздухе. Взвесь в воде имеет рН 7. МА представляет собой CuClj- 2 моль анилина, его выход в указанном способе достигает 89% при хорошем качестве. Изменение соотношения CuClj и анилина ведет к получению загрязненного целевого продукта. 1 табл. с (Л 00 00 СО ...

Трикапролактамомедь (п) сульфат дигидрат,обладающий фунгицидной активностью

Трикапролактамомедь (II) сульфат дигидрат формулы . СН2-СН2-СН2 ш.-сн, -г- С1180/1-2НгО. : о- . обладакщйй фунгицидной активностью § (Л ...

Способ получения комплексной соли глицината трехзамещенного фосфата меди

Бис-пара-аминосалицилато-бис-этилендиамин медь (п), дигидрат, проявляющий свойства биостимулятора роста и развития хлопчатника

Способ получения @ Тс-комплекса

Изобретение относится к элементоорганическим соединениям, в частности к получению 39тТс-номплекса ф- лы (СМ-А-ОСН3)61С X0, где А - C(CH3),-CH2C(CHi)a-,-CH(CH3)CHc- или -CCCH-jVCH -CH -, а Х& - неорганический анион, которые могут найти применение в медицине. Цель - разработка способа получения соединений , менее поглощаемых печенью и легкими и бопее легко выводимых из печени при высоком поглощении их миокардом . Получение ведут реакцией изонит-, рила СМ-А-ОСН, где А указано выше, с ТсО в присутствии дитионита натрия или соли двухвапентного олова и цистеина. 1 табл. с Ј (Л ...

Способ получения хелатных макроциклических соединений металлов

Makrocyclische Chelatbildner für Metallopharmazeutika

FUNGICIDAL HETEROCYCLIC COMPOUNDS

HETEROZYKLISCHE THION-VERBINDUNGEN UND IHRE ANWENDUNG ALS BIOZIDE.

VERFAHREN ZUR HERSTELLUNG VON MIT WISMUT MODIFIZIERTEM, SPHAEROIDISCHEM MALACHIT

SUBSTITUIERTE PHTHALOCYANINE.

Optischer Datenspeicher und Verfahren zu dessen Herstellung

VERFAHREN ZUM AUFLÖSEN VON KUPFERMETALL

1-AMINO-CYCLOPROPANCARBONSAEURE-METALLKOMPLEXVERBINDUNGEN, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS PFLANZENWACHSTUMSREGULATOREN

Komplexverbindungen mit einem mehrzähnigen, asymmetrischen Liganden und ihre Verwendung im opto-elektronischen Bereich

Beschrieben werden elektronische Vorrichtungen, enthaltend eine Metallkomplexverbindung mit einem ersten metallischen Zentrum M1 und einem zweiten metallischen Zentrum M2 und einem mehrzähnigen, asymmetrischen Liganden L1, der einen das erste und das zweite metallische Zentrum M1 und M2 verbrückenden Phosphido- oder Amido-Donor D1 aufweist sowie einen weiteren Donor D2, der entweder an das erste oder an das zweite metallische Zentrum bindet, sowie Verwendungen eines solchen Komplexes im elektronischen Bereich sowie zur Erzeugung von Licht sowie die Herstellung solcher Vorrichtungen.

SYNTHESIS OF alpha,beta-UNSATURATED COMPOUNDS

... 1,237,055. Ethylenically unsaturated compounds. ZOECON CORP. 17 Oct., 1969 [3 Feb., 1969; 11 April, 1969], No. 51168/69. Heading C2C. ,#-Ethylenically unsaturated compounds are prepared from ,#-acetylenically unsaturated acid esters, amides, aldehydes, ketones or nitriles, having on the #-carbon atom a hydrogen atom or a saturated or unsaturated, substituted hydrocarbon group, by reacting with an organometallic compound. The metal atom of the organo-metallic compound is copper (I), manganese (II), iron (II), cobalt (II), chromium (II) and chromium (III) and the organo group is a saturated or unsaturated, substituted or unsubstituted hydrocarbon group, which is added to the #-carbon atom of the acetylenically unsaturated compound. The organometallic compound may be prepared by reacting (a) a metal salt with organo-lithium; (b) a metal salt with organo-magnesium halide; or metal salt with diorgano-magnesium in an inert anhydrous organic solvent at from - 150‹ C. to room temperature. Examples ...

ISOTHIAZOLONE DERIVATIVES THEIR PREPARATION AND USE AS BIOCIDES

... 1390443 3-lsothiazolone derivatives and their preparation ROHM & HAAS CO 10 May 1972 [12 May 1971] 21941/72 Heading C2C [Also in Division C5] 3-Isothiazolones complexed with metal salts, e.g. complexes of the formula wherein Y is a hydrogen atom, an optionally substituted C 1-18 alkyl group, an optionally substituted C 2-18 alkenyl or alkynyl group, an optionally substituted C 3-12 cycloalkyl group, an optionally substituted aralkyl group of up to 10 carbon atoms, or an optionally substituted aryl group of up to 10 carbon atoms, R is hydrogen, halogen or a C 1-4 alkyl group, R1 is hydrogen, halogen or a C 1-4 alkyl group, or R and R1 can be joined together to complete a benzene ring which may be substituted by one or more halogen atoms, nitro groups, C 1-4 alkyl groups, C 1-4 alkoxy groups or cyano groups, M is a cation or a cationic complex of a metal, X is an anion forming a compound with the cation M, a is 1 or 2 and n is the integer for which the anion X satisfies ...

PHYSIOLOGICALLY TOLERABLE METAL COMPLEX SALTS FOR USE IN NMR DIAGNOSIS

A process for the manufacture of organic addition compounds containing heavy metals

Complex double compounds containing metals are prepared by combining non-noble heavy metal compounds derived from amines, acid amides including urea, nitriles, aminoalcohols or oximes which in aqueous or alcoholic solution do not have an acid reaction to phenol phthalein, with completely alkylated and/or arylated compounds of nitrogen, phosphorus or sulphur not substituted in the alkyl or aryl groups, or with alkyl and/or aryl phosphites. The metal compounds may be prepared in situ, e.g. by reacting the oxides or hydroxides of the metals with the nitrogen-containing organic compounds. The products are useful as additions to hydrocarbon mixtures; when added to gasolines they improve their anti-knock properties, whilst in the case of lubricants they render them suitable as extreme pressure lubricants or act as anti-oxidants. Examples of organic metallic compounds are cupro-urea, silver acetamide, cupro-aniline, nickel formamide and formanilide, cobalti - formanilide, cupro - acetamide and ...

A process for manufacturing organic addition compounds containing metals

Complex double compounds containing metals, which are useful as additions to hydrocarbons, e.g. gasoline, lubricating oils, tar oils, and brown coal products, as anti-detonants, anti-oxidants, or improvers, comprise the reaction products of an alkali metal derivative of an aromatic hydrocarbon with a complex compound formed of an inorganic or organic non-noble heavy metal compound and a completely alkylated and/or arylated compound of nitrogen, phosphorus or sulphur not substituted in the alkyl or aryl group. The radicle attached to the metal in the latter complex compounds is thereby replaced by an aromatic hydrocarbon radicle. Examples are given of the preparation of cuprophenyl-triethyl phosphine, nickel diphenyl-triethyl phosphine, cuprophenyl-trimethylamine, and silver a -naphthyl-triethyl phosphine. In addition, the following components are referred to: pyridine, triethylamine, tripropyl phosphine, triphenyl phosphine, thioether, ethylene diethyl sulphide and dibutyl sulphide. Specifications ...

METAL SALT AMINE XOMPLEXES

Defective metal-organic framework desulfurization adsorbent and its preparation method and use

A method of preparing a defective metal-organic framework suitable for use as a desulfurization adsorbent. The preparation method comprises initially dissolving trimesic acid and 5-hydroxyisophthalic acid in a solvent and sonicating them to form solution 1. Copper nitrate trihydrate is added to the solution to form solution 2. Solution 2 is then subjected to a microwave-assisted synthesis to obtain the desired metal-organic framework. The solvent can be one or more of water, anhydrous ethanol, N,N-dimethylformamide or acetone. Preferably the microwave-assisted synthesis involves heating from 20-35 °C to 95-105 °C at a rate of 4-6 °Cmin-1, maintaining this target temperature for between 10 and 20 min followed by a second heating step to between 115 and 125 °C at a rate of 1-2 °C and maintaining this temperature for 30 mins. A microwave power of between 500-1000 W is used. Preferably the molar ratio of benzene-1,3,5-tricarboxylic acid and 5-HIPA is between 1-9 and 3-7. Post-treatment can ...

New carbamates hydroxyarylakyleneaminoarylic and their derivatives, useful like insecticidal compounds.

Fungicidal heterocyclic compounds.

FIGHT AGAINST ALGAE AND WATER WEEDS

COPPER (I) FORERUNNER FOR the CHEMICAL VAPOR PHASE SEPARATION OF METALLIC COPPER

MORE DIKUPFER (I) OXALATE COMPLEXES THAN PRECURSOR FOR METALLIC COPPER SEPARATION

FUNGIZIDES MITTEL

VERFAHREN ZUM REGENERIEREN VON STROMLOS ARBEITENDEN METALLABSCHEIDUNGSBAEDERN

PROCEDURE FOR REGENERATING DEAD WORKING METALLABSCHEIDUNGSBAEDERN

PROCEDURE FOR the PRODUCTION of NEW of METAL COMPLEXES OF 3-ISOTHIAZOLONEN

DIAGNOSTIC MEANS

METAL COMPLEXES FOR THE METATHESE

CLEANING AGENT WITH BLEACH-CATALYTICALLY ACTIVE ONE COMPLEXES

PROCEDURE FOR the PRODUCTION of NEW 13-CIS-PROSTAGLANDINDERIVATE

PROCEDURE FOR THE PRODUCTION OF KUPRAT COMPLEXES OF HIGHER ORDER.

STABILIZATION OF ISOTHIAZOLONEN

CHELATIERUNGSMITTEL TO THE CONNECTION FROM METAL IONS TO PROTEINS.

METAL RADIONUCLIDE MARKED PROTEIN FOR DIAGNOSIS AND THERAPY.

PRODUCTION OF PURE AMINOSAEURECHELATEN OF THE PHARMACEUTICAL QUALITY.

METAL ISO NITRILE ADDITION PRODUCTS FOR THE PRODUCTION OF RADIONUKLEIDKOMPLEXEN.

PROCEDURE FOR THE PRODUCTION OF CUPRAT COMPLEXES OF HIGHER ORDER.

METAL-RADIONUCLIDE-MARKED PROTEINS AND GLYKOPROTEINE TO THE DIAGNOSIS AND THERAPY.

PROCEDURE FOR THE PRODUCTION OF PRO DAY LAND IN SIMILAR ONE BY ORGANOZIRKONIUMDERIVATEN.

FUNGICIDES HETERO-CYCLIC CONNECTIONS.

DIPYRIDOXYL PHOSPHATE AS MAGNETIC NUCLEAR RESONANCE PICTURE GIVING MEANS.

CUPREOUS POLYMERS, PROCEDURES FOR YOUR PRODUCTION AND YOUR APPLICATION AS FUNGICIDES.

HETERO-CYCLIC COPPER COMPLEXES.

CATALYSTS

Fungicide means

Procedure for the production of derivatives of hydroxyl connections

USE OF WATER AND ACIDIFIED WATER FOR THE CLEANING OF LIQUID MOCVD PRECURSOR COMPOUNDS

MISOPROSTOL, PROCEDURES FOR THE THEIR PRODUCTION WITH USE OF AN ORGAN COMET ALL COPPER COMPLEX

Procedure for the production of Dibenzocycloheptaenverbindungen and their salts

METALLCHELATVERBINDUNG, RADIO-PHARMACEUTICAL PRODUCT, PROCEDURE FOR ITS PRODUCTION AND DIAGNOSTIC KIT

PRODUCTION OF METAL COMPLEXES OF AMINO ACIDS, MANUFACTURED BY HYDROLYSIS OF SOJAPROTEIN

OPTICAL MATERIAL

AROMATIC AMINE-SUBSTITUTED LIGANDS WITH VERB-MOVED STICKSTOFF-UND SULFUR DONOR ATOMS FOR PICTURE FIGURATION

3-HYDROXY-2-%3-HYDROXY-1-OCTYNYL<-5-OXOCYCLOPENTANEHEPTANOIC ACID

TREATMENT OF LIQUIDS CONTAINING COMPLEXED METALS AND COMPLEXING AGENTS

THIAZOLIDIN-AND HYDROTHIAZIN-DERIVATIVES

Formulations of PSMA imaging agents

The present invention relates to formulations of radiolabeled compounds that are of use in radiotherapy and diagnostic imaging related to prostate specific membrane antigen (PSMA).

SELF-DECONTAMINATING METAL ORGANIC FRAMEWORKS

A self-decontaminating metal organic framework including an acid linked to a metal producing a metal organic framework configured for the sorption of chemical warfare agents and/or toxic industrial chemicals, the metal organic framework including reactive sites for the degradation of the agents and chemicals. 1. A method for producing a self-decontaminating metal organic framework , the method comprising:combining an acid with a linking agent and a metal to produce a self-decontaminating metal organic framework for sorption of chemical warfare agents and/or toxic industrial chemicals, the self-decontaminating metal organic framework including reactive sites for the degradation of said agents and chemicals.2. The method of in which the acid is a triple bonded acid.3. The method of in which the acid is acetylenedicareoxylic acid (ADA).4. The method of in which the metal is copper nitrate.5. The method of in which the self-decontaminating metal organic framework is linked to the metal with a linking agent.6. The method of in which the linking agent includes Pyrazine claim 5 , 2 claim 5 ,6-dimethylpyrazine claim 5 , 2-6-dichloropyrazine claim 5 , dipyridylethlene claim 5 , 4 claim 5 ,4′-dipyridyl claim 5 , or 2 claim 5 ,3 claim 5 ,5 claim 5 ,6-tetramethylpyrazine.7. The method of further including the step of adding an enzyme to the metal organic framework to assist in the degradation of said agents and chemical.8. The method of in which the size of the pores of the self-decontaminating metal organic framework are tailored for specific said agents and chemicals.9. The method of in which the surface area of the self-decontaminating metal organic framework is tailored for specific said agents and chemicals.10. A method of absorbing and degrading chemical warfare agents and toxic industrial chemicals claim 1 , the method comprising:adding a self-decontaminating metal organic framework to fabric or filter material, the self-decontaminating metal organic framework comprising ...

METHOD OF SYNTHESIZING A COMPLEX [CU(NNS)CL] ACTIVE AGAINST THE MALARIA PARASITE PLASMODIUM FALCIPARUM

Metal complex of Copper (II) containing a dithio-based ligand have been synthesized and characterized by elemental analysis, mass spectrometry, Proton NMR and FT-IR spectrometry. A single crystal X-ray structure of the copper complex has been analyzeThis paper describes the synthesis and characterization of the said metal complex containing deprotonated 3-[1-(2-pyridyl) ethylidene]hydrazinecarbodithioate ligand (FIG. ). 119-. (canceled)20. A method of producing a copper ligand chloride complex (CuLCl) having biological activity against a malaria parasite includes providing a source of 3-[1-(2-pyridyl) ethylidene]hydrazinecarbodithioate ligands (L) , deprotonating the ligands to form deprotonated ligands (L−) , contacting the deprotonated ligands with a copper chloride compound under conditions suitable to form the copper ligand chloride complex , and recovering the copper ligand chloride complex so formed.21. A method according to claim 20 , wherein the copper chloride compound is copper chloride dihydrate.22. A method according to claim 20 , wherein the source of ligands (L−) and copper chloride compound are provided respectively in solution claim 20 , the respective ligand and copper chloride solutions being mixed together to form a precipitate of the copper ligand chloride complex.23. A method according to claim 22 , wherein the copper chloride compound is dissolved in water to form the copper chloride solution and the source of ligands is dissolved in ethanol to form the ligand solution.24. A method according to claim 22 , wherein the copper ligand chloride complex precipitate is filtered off claim 22 , washed claim 22 , dried claim 22 , and then recrystallized.25. A method according to claim 24 , wherein the copper ligand chloride complex precipitate is recrystallized from acetone.26plasmodium falciparum.. A method according to claim 20 , wherein the copper ligand chloride complex is potent against the malaria parasite27plasmodium falciparum.. A method ...

COPPER ORGANIC METAL, METHOD FOR PREPARING COPPER ORGANIC METAL AND COPPER PASTE

Disclosed herein are a copper organic metal, a method for preparing a copper organic metal and a copper paste. The copper organic metal is constituted to combine a copper atom, [R—CO] and amine based ligand (L), thereby making it possible to be subjected to a low temperature sintering process and having an improved conductivity at the time of forming a conductive pattern as compared to the related art. 2. The copper organic metal according to claim 1 , wherein the amine based ligand includes alkylamine.3. The copper organic metal according to claim 2 , wherein the alkylamine is any one material selected from R—NH claim 2 , R—NH—R′ claim 2 , or R—N.4. The copper organic metal according to claim 1 , wherein the amine based ligand includes a hydroxyl (—OH) group.5. The copper organic metal according to claim 1 , wherein the amine based ligand includes HO—R—NH.6. A method for preparing a copper organic metal having an amine based ligand comprising:preparing a first solution by dissolving alkanoic acid or fatty acid in an aqueous sodium hydroxide solution or an aqueous potassium hydroxide solution;mixing the first solution and a second solution having a dissolved copper salt therein; andseparating and purifying a copper organic metal from the mixed solution including the first solution and the second solution.7. A method for preparing a copper organic metal having an amine based ligand comprising:preparing a first solution by dissolving alkanoic acid or fatty acid in an aqueous sodium hydroxide solution or an aqueous potassium hydroxide solution;mixing the first solution and a second solution having a dissolved copper salt therein;separating and purifying a copper organic metal from the mixed solution including the first solution and the second solution; andreacting the separated and purified copper organic metal with amine based solvent.8. The method according to claim 7 , wherein the amine based ligand includes alkylamine.9. The method according to claim 8 , wherein ...

Novel Imidazolium Salts and Carbene Metal Complexes Based Thereon for Use as Bioanalytical Markers for Biomolecules

The present invention relates to imidazolium salts, particularly imidazolium salts of the general formula I as well as the respective carbene metal complexes and their utilisation as bioanalytical tags for biomolecules. 2. Imidazolium salts according to claim 1 , wherein the groups R claim 1 , R claim 1 , and R claim 1 , where applicable claim 1 , are the same or different and chosen from the group of C-C-n-alkyl groups.3. Imidazolium salts according to claim 1 , wherein n claim 1 , m claim 1 , and q claim 1 , where applicable claim 1 , are zero or 1 and b and l are zero.4. Imidazolium salts according to claim 1 , wherein R″ is a C-C-n-alkyl group.7. Carbene metal complexes according to claim 6 , wherein the metal is chosen from the group consisting of copper claim 6 , iron claim 6 , ruthenium claim 6 , nickel claim 6 , and palladium or from the group consisting of technetium claim 6 , rhenium and cobalt.8. Carbene metal complexes according to claim 6 , wherein the ligand L is chosen from the group consisting ofCO;nitrile;isonitrile;nitrosyl;halogenide ion;hydrogen atom;{'sub': 1', '12', '6', '14', '1', '12', '6', '14', '1', '12', '6', '14', '1', '12', '6', '14', '6', '14', '1', '12', '1', '12, 'C-C-alkyl anion, allyl anion, methylallyl anion, benzyl anion, C-C-aryl anion, C-C-alkoxy anion, C-C-aryloxy anion, C-C-heteroalkyl anion, C-C-heteroaryl anion, C-C-heteroalkoxy anion, C-C-heteroaryloxy anion or C-C-heteroaryloxy anion, which is unsubstituted or the same or differently substituted by one or more C-C-alkyl groups or C-C-heteroalkyl groups, whereby the heteroatoms are chosen from the group B, Al, Ga, In, N, P, As, Sb, Bi, Si, Ge, Sn, Pb, O, S, Se, and Te and wherein the anions are unsubstituted or wholly or partially substituted with one or more than one, same, or different heteroatoms from the same group, in the form of functional groups, wherein the cyclic and aromatic systems are single rings or several annelated or isolated rings;'}primary, secondary, ...

HIGHLY HEAT-RESISTANT PHTHALOCYANINE

The problem addressed by the present invention is to provide a high heat-resistant phthalocyanine. The phthalocyanine is separated by mixing a phthalocyanine separation solvent and a phthalocyanine solution wherein a phthalocyanine starting material is dissolved in a solvent. THe phthalocyanine is wherein having high heat resistance, the decomposition temperature of the separated phthalocyanine being at least 10° C. higher than the decomposition temperature of the phthalocyanine starting material. Also, the phthalocyanine solution may be the result of dissolving at least two types of phthalocyanine starting material in the solvent, the separated phthalocyanine being wherein containing a solid solvent of the at least two types of phthalocyanine starting material and by the decomposition temperature of the separated phthalocyanine being at least 10° C. higher than the decomposition temperature of a mixture of at least two types of phthalocyanine separated by mixing the phthalocyanine separation solvent and each of at least two types of phthalocyanine solution resulting from dissolving each of the at least two types of phthalocyanine starting material in a solvent.

TREATING MYCOBACTERIAL INFECTION WITH CU+/++ BOOSTING THERAPEUTICS

Provided herein are methods of treating a subject with a mycobacterial infection. The methods comprise administering to the subject a Cu boosting therapeutic. Also provided are compositions comprising a Cu boosting therapeutic. Further provided are methods of screening for a Cu boosting therapeutic. 1. A method of treating a subject with a mycobacterial infection , the method comprising administering to the subject a Cu boosting therapeutic.2. The method of claim 1 , wherein the Cu boosting therapeutic is selected from the group consisting of a therapeutic pre-complexed with Cu; a therapeutic capable of complexing Cu from tissue claim 1 , blood claim 1 , or intracellular compartments; and a therapeutic that interferes with Cu homeostatsis without complexing Cu.3. The method of claim 2 , wherein the Cu boosting therapeutic is a therapeutic pre-complexed with Cu.5. The method of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , and Rare each independently selected from hydrogen and substituted or unsubstituted C-Calkyl.6. The method of claim 4 , wherein Rand Rare hydrogen.7. The method of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , and Rare each independently selected from hydrogen and methyl.11. The method of claim 3 , wherein the Cu boosting therapeutic is disulfiram pre-complexed with Cu.13. The method of claim 1 , further comprising administering to the subject a supplement capable of increasing Cu availability.14. The method of claim 1 , wherein the mycobacterial infection is the result of an infection by a bacteria from the Mycobacteriaceae family.15. A composition comprising a Cu boosting therapeutic.16. The composition of claim 15 , wherein the Cu+/++ boosting therapeutic is selected from the group consisting of a therapeutic pre-complexed with Cu; a therapeutic capable of complexing Cu from tissue claim 15 , blood claim 15 , or intracellular compartments; and a therapeutic that interferes with Cu homeostatsis without ...

COLOR MATERIAL AND METHOD FOR PRODUCING THE SAME

Color materials represented by the following general formula (I): 2. The color material according to claim 1 , wherein the anion (B) in the general formula (I) is an organic anion having a sulfonato group (—SO group).4. The color material according to claim 1 , wherein the anion (B) in the general formula (I) is an anion of an inorganic acid containing molybdenum and/or tungsten.5. The color material according to claim 1 , wherein “a” in the general formula (I) is 4 or less.6. The color material according to claim 1 , wherein the color material is a color material for being dispersed in a solvent having a solubility of the color material of 0.1 (mg/10 g solvent) or less at 23° C. The present invention relates to a novel color material with excellent heat resistance particularly, and a method for producing the same.Nowadays, a large number of dyes are known, and they are largely categorized into natural dyes and synthetic dyes. Examples of the synthetic dyes include aniline blue, fuchsine and methyl orange. Most of the synthetic dyes have an aromatic or heterocyclic ring, and they are classified as either ionic compounds (for example, all water-soluble dyes) or non-ionic compounds (for example, disperse dyes). In addition, in the case of the ionic dyes, they are categorized into anionic (negative ionic) dyes and cationic (positive ionic) dyes.The cationic dyes comprise an organic cation having a positive charge delocalized over a conjugated bond and normally an inorganic anion. Also, the cationic dyes are generally dyes in which an amino group which may have a substituent is involved in resonance. Therefore, selection of the cationic dyes depends on the number and kinds of the anion being a counter ion. Examples of the counter anion include a chloride ion, a bromide ion, an iodide ion, a perchlorate ion, a tetrafluoroborate ion, a hexafluorophosphate ion, an alkyl or aryl sulfate ion, a tosilate ion, an acetate ion and an oxalate ion.Generally, rhodamine, safranine ...

NOVEL CONTRAST AGENTS

This invention includes agents and compositions having MRI, PET, CT, X-ray, SPECT or optical signals, and methods for their use in the determination of a target. In some cases, a MRI, PET, CT, X-ray, SPECT, optical or other signal produced by the agent or composition can be affected by the presence of the target. Examples of targets that can be determined by this invention include, but are not limited to zinc, copper, iron ions and other biological targets. Example of application for imaging in vivo includes the function of pancreas and other organs. 5. The agent or composition according to claim 1 , wherein the target is a metal ion or a macromolecular receptor.6. The agent or composition according to claim 1 , wherein the target is Zn or Cu.7. The agent or composition according to claim 2 , wherein the target is a metal ion or a macromolecular receptor.8. The agent or composition according to claim 2 , wherein the target is Zn or Cu.9. The agent or composition according to claim 3 , wherein the target is a metal ion or a macromolecular receptor.10. The agent or composition according to claim 3 , wherein the target is Zn or Cu.11. The agent or composition according to claim 4 , wherein the target is a metal ion or a macromolecular receptor.12. The agent or composition according to claim 4 , wherein the target is Zn or Cu. This application is a continuation of U.S. patent application Ser. No. 12/748,445, filed Mar. 28, 2010, which claims priority to U.S. Provisional Application No. 61/225,187 filed Jul. 13, 2009, the disclosures of which are herein incorporated by reference.The present invention relates in general to the field of chelating agents, a method for preparing chelating agents and methods of using chelating agents in diagnostic and therapeutic applications.Without limiting the scope of the invention, its background is described in connection with contrast agents that detect a target in vivo for instance Zinc.In one aspect, this invention relates to ...

COMPOSITIONS AND METHODS COMPRISING CONDUCTIVE METAL ORGANIC FRAMEWORKS AND USES THEREOF

Compositions and methods comprising metal organic frameworks (MOFs) and related uses are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core. 140-. (canceled)41. Use of a MOF as a conductive material , wherein the MOF comprises:a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core.42. (canceled)43. Use of a MOF for chemical sensing , wherein the MOF comprises:a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core.4445-. (canceled)46. The use of claim 41 , wherein a portion of the metal ions are associated with two claim 41 , three claim 41 , or four ligands claim 41 , and each of those ligands is individually associated with one claim 41 , two claim 41 , three claim 41 , or four metal ions.47. The use of claim 41 , wherein the at least two sets of ortho-diimine groups are least two sets of ortho-phenylenediimine groups.48. The use of claim 41 , wherein each metal ion is a monovalent claim 41 , divalent claim 41 , or trivalent metal ion.49. The use of claim 41 , wherein each metal ion is Ag claim 41 , Cu claim 41 , Au claim 41 , Mg claim 41 , Mn claim 41 , Fe claim 41 , Co claim 41 , Ni claim 41 , Cu claim 41 , Pd claim 41 , Pt claim 41 , Ru claim 41 , Cd claim 41 , Zn claim 41 , Pb claim 41 , Hg claim 41 , V claim 41 , Cr claim 41 , Ni claim 41 , Fe claim 41 , V claim 41 , Ti claim 41 , Sc claim 41 , Al claim 41 , In claim 41 , Ga claim 41 , Mn claim 41 , Co claim 41 , and/or Cr.50. The use of claim 41 , wherein the organic core comprises a plurality of fused aryl and/or heteroaryl rings.51. The use of claim 41 , wherein the organic core comprises one or more of benzyl claim 41 , thiophenyl claim 41 , carbazolyl claim ...

COPPER (I) COMPLEXES WITH GLYCINE, PYRUVATE, AND SUCCINATE

The present invention is directed to a pharmaceutical and/or dietary supplement composition comprising an effective amount of a copper (I) complex with glycine, pyruvate, or succinate and methods of treating mitochondrial, neuromuscular, and other diseases. Also provided are pharmaceutical treatment regimes and kits comprising a copper (I) complex with glycine, pyruvate, or succinate. 43. The composition of any of - claims 1 , wherein the pharmaceutically acceptable carrier is an inert diluent and/or an extended release formulation.54. The composition of any of - claims 1 , further comprising a delivery vehicle selected from a liposome claims 1 , a microsome claims 1 , a nanosome claims 1 , a picosome claims 1 , a pellet claims 1 , a granular matrix claims 1 , a bead claims 1 , a microsphere claims 1 , a nanoparticle formulation claims 1 , or an aqueous solution.65. The composition of any of - claims 1 , further comprising copper ascorbate and/or ascorbic acid.76. The composition of any of - claims 1 , wherein the effective amount is between 1 mg and 20 mg.86. The composition of any of - claims 1 , wherein the effective amount is between 5 mg and 10 mg.96. The composition of any of - claims 1 , wherein the effective amount is between 7.5 mg and 10 mg.106. The composition of any of - claims 1 , wherein the effective amount is about 10 mg.1514. The method of any of - claims 11 , wherein the subject is a human.1614. The method of any of - claims 11 , wherein the compound is administered in a dose between 1 mg and 20 mg per day.1714. The method of any of - claims 11 , wherein the compound is administered in a dose between 5 mg and 10 mg per day.1814. The method of any of - claims 11 , wherein the compound is administered in a dose between 7.5 mg and 10 mg per day.1914. The method of any of - claims 11 , wherein the compound is administered in a dose of about 10 mg per day.21. The pharmaceutical treatment regime of claim 20 , wherein the pharmacologically active ...

Azolium Metal-Organic Frameworks

Disclosed herein are metal-organic frameworks comprising at least two azolium rings. The azolium groups are used as a strategy for controlling catenation and morphology in metal-organic frameworks. 1. A method for reducing , eliminating or inhibiting catenation in a metal-organic frameworks (MOF) , the method comprisingproviding a biphenyl dicarboxylate derivative having at least two charged groups projecting into pores of the metal-organic framework, the at least two charged groups repulsing each other due to electrostatic van der Waals interactions; andreducing, eliminating or inhibiting cantentation of the metal-organic framework.2. The method according to wherein the metal-organic framework is an azolium-based metal organic framework.5. The method according to wherein the metal ion is Cu.6. The method according to wherein the structure has a formula selected from the group consisting of Cu(4).2 (DMF/EtOH) and ZnO(4) claim 4 , wherein DMF and EtOH are solvent molecules dimethylformamide and ethanol claim 4 , respectively claim 4 , and y is the number of DMF solvent molecules. This application is a continuation of and claims priority to and the benefit of application Ser. No. 13/889,988 filed May 8, 2013 and issued as U.S. Pat. No. 9,090,634 on Jul. 28, 2015, which claimed priority to and the benefit of Ser. No. 61/644,246 filed on May 8, 2012—each of which is incorporated herein by reference in its entirety.This invention was made with government support under FA9550-07-1-0534 awarded by the Air Force Office of Scientific Research. The government has certain rights in the invention.The present invention relates generally to a metal-organic framework comprising at least two azolium rings. The azolium groups are used as a strategy for controlling catenation and morphology in metal-organic frameworks.Metal-organic frameworks (MOFs) have emerged as a promising class of functional materials due to their microporosity, high internal surface area, and the ability to ...

HEXAFLUORODIMETHYLCARBINOL TERMINATED ALKANE- AND ALKENETHIOLS

A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF)C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CHCH═CH—) and trimethylene group (—CHCHCH—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH)—, —(OCHCH)—, and —(Si(CH)O)—Si(CH)—(CH)—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF)(OH), wherein Z represents a thiol protecting group. 1. A composition of matter comprising a metal surface and a group having a general structure represented by (CF)C(OH)-L-M-S— bound to the metal surface:{'sub': 2', '2', '2', '2, 'wherein L is selected from optionally substituted —CH—CH═CH— and —CH—CH—CH—; and'}wherein M is selected from substituted or unsubstituted methylene chain, substituted or unsubstituted oxyalkylene chain, alkyl-substituted or unsubstituted silicon-containing chain, and combinations and multiples thereof.2. The composition of matter of ;{'sub': 2', 'n', '2', '2', 'm', '3', '2', 'p', '3', '2', '2', 'q, 'wherein M is selected from —(CH), —(OCHCH)—, —(Si(CH)O)—Si(CH)—(CH)—, and combinations thereof; and'}wherein n>0; m>0; p>0; and q>1.3. The composition of matter of claim 1 , wherein the metal surface comprises gold.4. The composition of matter of claim 1 , wherein the composition of matter comprises a substrate comprising the metal surface and a film on the metal surface comprising a compound which includes the group (CF)C(OH)-L-M-S—.5. The composition of matter of claim 4 , wherein the compound is present in ...

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

The present disclosure provides amide M carbene emitters of Formula (I); organic light emitting device (OLED) comprising an anode, a cathode, and an organic layer, disposed between the anode and the cathode, comprising a compound of Formula (I); and consumer products comprising an OLED comprising a compound of Formula (I): 2. The compound of claim 1 , wherein M is selected from the group consisting of Cu claim 1 , Ag claim 1 , and Au.3. The compound of claim 1 , wherein ring A is represented by formula (Aii).5. The compound of claim 1 , wherein ring A is represented by formula (Ai).7. The compound of claim 6 , wherein each of Xto Xindependently represents C.17. A formulation comprising the compound of . The present application claims priority to U.S. Provisional Application No. 63/061,263, filed Aug. 5, 2020, which is incorporated by reference herein in its entirety.The present disclosure relates to compounds for use as emitters, and devices, such as organic light emitting diodes, including the same.The claimed invention was made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: Regents of the University of Michigan, Princeton University, University of Southern California, and the Universal Display Corporation. The agreement was in effect on and before the date the claimed invention was made, and the claimed invention was made as a result of activities undertaken within the scope of the agreement.Opto-electronic devices that make use of organic materials are becoming increasingly desirable for a number of reasons. Many of the materials used to make such devices are relatively inexpensive, so organic opto-electronic devices have the potential for cost advantages over inorganic devices. In addition, the inherent properties of organic materials, such as their flexibility, may make them well suited for particular applications such as fabrication on a flexible substrate. Examples of ...

GOLD(III) COMPLEXES AS ANTICANCER AGENTS AND A METHOD OF TREATING CANCER

Gold(III) complexes containing mixed ligands. A method of treating cancer with these complexes is disclosed. The complexes are cytotoxic to prostate, breast, ovarian, and Hodgkin lymphoma cancer cell lines. These complexes were either more potent than cisplatin or had similar potency to cisplatin. 2. The gold(III) complex of claim 1 , wherein the gold(III) complex is represented by formula (III) claim 1 , a salt thereof claim 1 , a solvate thereof claim 1 , a derivative thereof claim 1 , or a prodrug thereof claim 1 , and R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare independently a hydrogen or an optionally substituted alkyl.3. The gold(III) complex of claim 2 , wherein Rand Rare independently an optionally substituted alkyl or an optionally substituted arylalkyl.4. The gold(II) complex of claim 3 , further comprising a counterion which is at least one pharmaceutically acceptable anion selected from the group consisting of fluoride claim 3 , chloride claim 3 , bromide claim 3 , iodide claim 3 , nitrate claim 3 , sulfate claim 3 , phosphate claim 3 , methanesulfonate claim 3 , ethanesulfonate claim 3 , p-toluenesulfonate claim 3 , salicylate claim 3 , malate claim 3 , maleate claim 3 , succinate claim 3 , tartrate claim 3 , citrate claim 3 , acetate claim 3 , perchlorate claim 3 , trifluoromethanesulfonate claim 3 , acetylacetonate claim 3 , hexafluorophosphate claim 3 , and hexafluoroacetylacetonate.5. The gold(III) complex of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , and Rare independently a hydrogen or a methyl claim 4 , and Rand Rare independently a methyl claim 4 , an ethyl claim 4 , or benzyl.6. A pharmaceutical composition claim 4 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the gold(II) complex of ; and'}at least one pharmaceutically acceptable carrier and/or excipient.7. The pharmaceutical composition of claim 6 , wherein the at ...

WATER CAPTURE METHODS, DEVICES, AND COMPOUNDS

A method of capturing water from a gaseous composition comprising water vapour (e.g., air), the method comprising: 143.-. (canceled)44. A method of capturing water from a gaseous composition , the method comprising:providing a metal-organic material configured to capture water from the gaseous composition;contacting the metal-organic material with the gaseous composition;wherein the gaseous composition comprises one or more of water or water vapor; andwherein the metal-organic material adsorbs water from the gaseous composition.45. The method of claim 44 , further comprising storing the metal-organic material after the metal-organic material adsorbs water from the gaseous composition.46. The method of claim 45 , further comprising applying a stimulus to the metal-organic material at a time after storage to effect desorption of water retained therein.47. The method of claim 46 , further comprising collecting desorbed water.48. The method of claim 44 , wherein the metal-organic material comprises metal species and one or more ligands.49. The method of claim 48 , wherein the metal species is selected from copper claim 48 , cobalt claim 48 , nickel claim 48 , iron claim 48 , zinc claim 48 , cadmium claim 48 , zirconium claim 48 , magnesium claim 48 , calcium and aluminium.50. The method of claim 48 , wherein the one or more ligands are selected from bidentate nitrogen ligands claim 48 , nitrogen-carboxylate ligands and polycarboxylate ligands.51. The method of claim 50 , wherein the one or more ligands are selected from 4 claim 50 ,4′ -bipyridine (L1) claim 50 , 1 claim 50 ,4-bis(4-pyridyl)benzene (L2) claim 50 , 4 claim 50 ,4′ -(2 claim 50 ,5 -dimethyl-1 claim 50 ,4-phenylene)dipyridine (L3) claim 50 , 1 claim 50 ,4-bis(4-pyridyl)biphenyl (L4) claim 50 , 1 claim 50 ,2-di(pyridine-4-yl)-ethene (L5) claim 50 , benzotriazole-5-carboxylic acid (L128) claim 50 , 2 claim 50 ,4-pyridinedicarboxylic acid (L80) claim 50 , glutaric acid (L141) claim 50 , and benzene-1 claim 50 , ...

LIGAND PASSIVATED GOLD NANOPARTICLES

The invention provides novel gold nanoclusters of the formula Au(SR)(weak ligand), wherein each R is independently an organic group, and the weak ligand is a weakly associating gold ligand of Formula I as described herein. The nanocluster can have an approximate molecular weight of 6 kDa. Corresponding dimers of the nanocluster can have an approximate molecular weight of 10 kDa (by SEC). The invention also provides methods of making and using the gold nanoclusters. 2. The gold nanocluster of further comprising a second gold nanocluster claim 1 , thereby forming a discrete gold nanocluster of the formula (Au(SR))(weak ligand) claim 1 , wherein the nanocluster has an approximate molecular weight of 10 kDa and is orange in color upon isolation.3. The gold nanocluster of wherein the nanocluster is water-soluble.4. The gold nanocluster of wherein the nanocluster is organo-soluble.5. The gold nanocluster of wherein x is 20 claim 1 , 24 claim 1 , 25 claim 1 , or 28.6. The gold nanocluster of wherein y is 15 claim 1 , 17 claim 1 , or 19.7. The gold nanocluster of wherein each Rand Ris OMe.8. The gold nanocluster of wherein n is 1 claim 1 , 2 claim 1 , or 3.9. The gold nanocluster of wherein the weak ligand of Formula I is diethylene glycol dimethyl ether claim 1 , triethylene glycol dimethyl ether claim 1 , or tetraethylene glycol dimethyl ether.10. The gold nanocluster of wherein -SR is the thiolate of glutathione claim 1 , cysteine claim 1 , captopril claim 1 , thiomalic acid claim 1 , N-(2-mercaptopropionyl)glycine claim 1 , p-mercaptobenzioc acid claim 1 , m-mercaptobenzoic acid claim 1 , furan-2-ylmethanethiol claim 1 , penicillamine claim 1 , a (C-C)mercaptoalkanoic acid claim 1 , 2-phenylethanethiol (PET) claim 1 , 1-phenylethanethiol claim 1 , benzyl mercaptan claim 1 , thiophenol claim 1 , a (C-C)alkylthiol claim 1 , a (C-C)mercaptocycloalkane claim 1 , a (C-C)mercaptoalkanoic acid claim 1 , dimercaptosuccinic acid claim 1 , 2-mercaptoethanol claim 1 , 3- ...

WATER STABLE COPPER PADDLEWHEEL METAL ORGANIC FRAMEWORK (MOF) COMPOSITIONS AND PROCESSES USING THE MOFS

This invention relates to a Cu-BTC MOF which is water stable. The Cu-BTC MOF has open coordination sites and has been post synthesis modified by partially occupying the open sites with a ligand such as acetonitrile (CHCN). The resultant MOF retains at least 40% of its as synthesized surface area after exposure to liquid water at 60° C. for 6 hours. This is an unexpected result versus the MOF which has not been post treated with ligands such as acetonitrile. This MOF can be used to abate contaminants such as ammonia in gas streams and especially air streams. 1. A metal organic framework (MOF) composition comprising:{'sub': '3', 'a coordination product of a copper metal ion and 1,3,5-benzenetricarboxylic acid (BTC) ligand the MOF characterized in that the copper has open coordination sites which are at least partially occupied by acetonitrile (CHCN) and it retains at least 40% of its as synthesized surface area after exposure to liquid water at room temperature for 6 hours.'}2. The composition of further characterized in that the MOF has an as synthesized Brunauer-Emmett-Teller (BET) surface area of at least 1200 m/g.3. The composition of further characterized in that the MOF has a gravimetric uptake capacity for ammonia of at least 0.3 g of ammonia per gram of MOF measured at 675 torr and 25° C.4. The MOF of further characterized in that the MOF has a pore volume of at least 0.5 cc/g.5. The MOF of where the MOF retains at least 50% of its synthesized surface area after exposure to liquid water at room temperature for 6 hours.6. The MOF of further characterized in that the MOF is formed into a shaped body selected from pellets claim 1 , spheres claim 1 , disks claim 1 , monolithic body claim 1 , irregularly shaped particles claim 1 , extrudates claim 1 , and mixtures thereof.7. The MOF of further characterized in that the MOF is deposited as a layer on a support selected from a monolith claim 1 , spherical support claim 1 , ceramic foam claim 1 , woven fabrics claim 1 ...

Molecular Imaging Probes

This disclosure relates to compounds of formula (I) shown below: [formula (I)], or a pharmaceutically acceptable salt thereof. These compounds can be used as imaging probes, e.g., for diagnosis of fibrosis or fibrogenesis. 2. The compound of claim 1 , wherein the first complexing group is a DOTA claim 1 , NOTA claim 1 , DO3AX claim 1 , DO3AP claim 1 , DOTP claim 1 , DO2A2P claim 1 , NOTP claim 1 , NO2AP claim 1 , NO2PA claim 1 , TETA claim 1 , TE2P claim 1 , TE2A claim 1 , TE1A1P claim 1 , CBTE2P claim 1 , CBTE1A1P claim 1 , SBTE2A claim 1 , SBTE1A1P claim 1 , DTTP claim 1 , CHX-A″-DTPA claim 1 , Desferal claim 1 , HBED claim 1 , PyDO3P claim 1 , PyDO2AP claim 1 , PyDO3A claim 1 , DIAMSAR claim 1 , EDTA claim 1 , DTP A claim 1 , CB-TE2A claim 1 , SarAr claim 1 , PCTA claim 1 , pycup claim 1 , DEDPA claim 1 , OCTAPA claim 1 , AAZTA claim 1 , DOTAIa claim 1 , CyPic3 A claim 1 , TRAP claim 1 , NOPO claim 1 , or CDTA moiety.3. The compound of claim 1 , wherein the metal ion is selected from Gd claim 1 , Mn claim 1 , Mn claim 1 , Fe claim 1 , Ce claim 1 , Pr claim 1 , Nd claim 1 , Eu claim 1 , Eu claim 1 , Tb claim 1 , Dy claim 1 , Er claim 1 , Ho claim 1 , Tm claim 1 , Yb claim 1 , and Cr claim 1 , or is an ion of a radioisotope selected from the group consisting of Ga claim 1 , Ga claim 1 , Al-F claim 1 , 64Cu claim 1 , In claim 1 , Mn claim 1 , Zr claim 1 , Y claim 1 , Tl claim 1 , Tc claim 1 , and Tc.4. The compound of claim 1 , wherein X is —C(RR)— claim 1 , —C(S)— claim 1 , or —C(O)— claim 1 , in which each of Rand R claim 1 , independently claim 1 , is H claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , or aryl.5. (canceled)6. The compound of claim 1 , wherein Y is —N(R)— or —O— claim 1 , in which Ris H claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , or aryl.7. (canceled)8. The compound of claim 1 , wherein L is —(CH)— claim 1 , —NH(CH)— claim 1 , or —(CH)—aryl- claim 1 , in which n is 1 claim 1 , 2 claim 1 , or 3.9. ( ...

METAL-MEDIATED REVERSIBLE SELF-ASSEMBLY OF CARBON NANOTUBES

There is provided a method and nanocomposite for the reversible assembly of nanotubes, such as oxidized single wall carbon nanotubes, based on metal coordination. The method produces a thermally stable, neutral nanocomposite possessing enhanced mechanical, electrical, physical and chemical properties for example. Disassembly can be provided by treatment with a competing ligand compound. 1. A method of preparing a nanocomposite , the method comprising the steps of: reacting first and second nanotubes with a metal complex in a solvent system to form an assembled complex , wherein the metal complex is comprised of a metal and a ligating portion selected from monotopic , ditopic and polytopic ligands coordinated to the metal , and wherein each of the first and second nanotubes includes at least one ligating component coordinating with the metal such that the metal complex serves to connect the first and second nanotubes.2. The method of claim 1 , where the assembled complex is disassembled upon treatment with a competing ligand component.3. The method of claim 1 , where the nanotubes are selected from the group consisting of organic nanotubes claim 1 , inorganic nanotubes claim 1 , single-wall nanotubes and multi-walled nanotubes.4. The method of claim 1 , where the metal of the metal complex is selected from zinc and copper (II).5. The method of claim 1 , where the ligating portion is selected from the group consisting of functionalized monopyridines claim 1 , bispyridines claim 1 , terpyridines and polypyridine ligands.6. The method of claim 1 , where the ligating component is a monotopic or polytopic ligand capable of coordinating a metal that can coordinate with organic or inorganic nanotubes.7. The method of claim 1 , where at least one of the nanotube and the ligating component is selectively modified with at least one substituent providing at least one physicochemical property claim 1 , the physiochemical property including solubility claim 1 , blendablility ...

METHOD FOR ADSORBING CARBON DIOXIDE ONTO POROUS METAL-ORGANIC FRAMEWORK MATERIALS, METHOD FOR COOLING POROUS METAL-ORGANIC FRAMEWORK MATERIALS, METHOD FOR OBTAINING ALDEHYDE USING POROUS METAL-ORGANIC FRAMEWORK MATERIALS, AND METHOD FOR WARMING POROUS METAL-ORGANIC FRAMEWORK MATERIALS

The present invention provides a method for adsorbing carbon dioxide onto porous metal-organic framework materials, a method for cooling porous metal-organic framework materials, a method for obtaining aldehyde using porous metal-organic framework materials and a method for warming porous metal-organic framework materials. In each method, porous metal-organic framework materials are used while an electric field or an electromagnetic field is applied to the porous metal-organic framework materials, or while a magnetic field or an electromagnetic field is applied to the porous metal-organic framework materials. If an electric field is applied, at least one organic compound included in the porous metal-organic framework materials is a polar compound. Instead, if a magnetic field is applied, at least one metal included in the porous metal-organic framework materials has an unpaired electron. 1. A method for cooling porous metal-organic framework materials , the method comprising:(a) applying an electric field or an electromagnetic field to the porous metal-organic framework materials containing an adsorbate such that the adsorbate is released from the porous metal-organic framework materials, wherein at least one metal ion, and', 'at least one organic compound bound by coordination bond to the at least one metal ion; and, 'the porous metal-organic framework materials contain'}the at least one organic compound is a polar compound.2. The method according to claim 1 , whereinthe adsorbate is selected from the group consisting of water, ammonia, hydrogen fluoride, alcohol, aldehyde, carboxylic acid, amine, amide, imide, fluorinated hydrocarbon and chlorofluorocarbon.3. The method according to claim 1 , whereinthe electric field is an alternating-electric field.4. The method according to claim 1 , whereinthe at least one metal ion is a copper ion.5. The method according to claim 1 , whereinthe at least one organic compound is 1,3-benzene dicarboxylic acid.6. A method for ...

GROUP 11 MONO-METALLIC PRECURSOR COMPOUNDS AND USE THEREOF IN METAL DEPOSITION

The present application provides precursor compounds useful for deposition of a group 11 metal on a substrate, for example, a microelectronic device substrate, as well as methods of synthesizing such precursor compounds. The precursor compounds provided are mono-metallic compounds comprising a diaminocarbene (DAC) having the general formula: “DAC-M-X”, where the diaminocarbene is an optionally substituted, saturated N-heterocyclic diaminocarbene (sNHC) or an optionally substituted acyclic diaminocarbene, M is a group 11 metal, such as copper, silver or gold; and X is an anionic ligand. Also provided are methods of synthesizing the precursor compounds, metal deposition methods utilizing such precursor compounds, and to composite materials, such as, e.g., microelectronic device structures, and products formed by use of such precursors and deposition methods. 1. A compound of Formula I:{'br': None, 'DAC-M-X\u2003\u2003I'} DAC is a diaminocarbene that is an optionally substituted, saturated N-heterocyclic diaminocarbene (sNHC) or an optionally substituted acyclic diaminocarbene;', 'M is a transition metal bound to the DAC component at the carbenic atom; and', 'X is an anionic ligand,', 'wherein the compound does not comprise an aryl or heteroaryl group, and M is bound to a non-halogenic atom of X,', 'and wherein the compound will achieve a vapour pressure of at least about 1 torr at 160° C. or less and will remain stable for at least one day at a temperature of at least about 100° C., 'wherein'}2. The compound of claim 1 , wherein M is a group 11 metal.3. The compound of claim 1 , which is a compound of Formula Ia:{'br': None, 'i': 's', 'NHC-M-X\u2003\u2003Ia.'}6. The compound of claim 1 , wherein X is not bound to M via an oxygen-metal bond.8. The compound of claim 7 , wherein Rand Rare each independently H claim 7 , a Cto Calkyl or heteroalkyl claim 7 , or a Cto Ccycloalkyl or cyclic heteroalkyl.9. The compound of claim 8 , wherein X is —N(SiMe).10. The compound of ...

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

The present invention includes novel heteroleptic/homoleptic iridium complexes containing two tridentate ligands, where at least one of the tridentate ligands comprises of pyridinium-derived N-heterocyclic carbene. The compounds of the present invention may be useful for organic electroluminescent devices. 2. The compound of claim 1 , wherein each R claim 1 , R claim 1 , and Rare independently selected from the group consisting of hydrogen claim 1 , deuterium claim 1 , fluorine claim 1 , alkyl claim 1 , cycloalkyl claim 1 , heteroalkyl claim 1 , alkoxy claim 1 , aryloxy claim 1 , amino claim 1 , silyl claim 1 , alkenyl claim 1 , cycloalkenyl claim 1 , heteroalkenyl claim 1 , aryl claim 1 , heteroaryl claim 1 , nitrile claim 1 , isonitrile claim 1 , sulfanyl claim 1 , and combinations thereof.3. The compound of claim 1 , wherein each R claim 1 , R claim 1 , and Rare independently selected from the group consisting of deuterium claim 1 , fluorine claim 1 , alkyl claim 1 , cycloalkyl claim 1 , alkoxy claim 1 , aryloxy claim 1 , amino claim 1 , silyl claim 1 , aryl claim 1 , heteroaryl claim 1 , sulfanyl claim 1 , and combinations thereof.4. The compound of claim 1 , wherein M is selected from the group consisting of Ir claim 1 , Rh claim 1 , Re claim 1 , Ru claim 1 , Os claim 1 , Pt claim 1 , Au claim 1 , and Cu.5. The compound of claim 1 , wherein each of Xto Xare C.6. The compound of claim 1 , wherein ring A is a 6-membered aromatic ring.7. The compound of claim 6 , wherein ring A is a N-heteroaromatic ring selected from the group consisting of pyridyl claim 6 , pyrimidyl claim 6 , pyrazinyl claim 6 , pyridiznyl and benzo-analogs of each thereof.8. The compound of claim 1 , wherein ring A is a 5-membered N-heteroaromatic ring selected from the group consisting of imidazole claim 1 , pyrazole claim 1 , 1 claim 1 ,2 claim 1 ,3 claim 1 , triazole claim 1 , 1 claim 1 ,2 claim 1 ,4 claim 1 , triazole claim 1 , oxazole claim 1 , isoxazole claim 1 , thiazole claim 1 , ...

MOLECULAR HYDROGEN ADSORBENT COMPRISING COPPER-BTC MOF

Mixed metal metal-organic frameworks (MM-MOFs) of copper-1,3,5-benzenetricarboxylate (BTC), M—Cu-BTC, wherein M is Zn(II), Ni(II), Co(II), and/or Fe(II) may be made using post-synthetic exchange (PSE) with metal ions. Such MM-MOFs may be used in Hstorage, especially Ni(II) and Co(II) MM-MOFs. Selected metal exchanged materials can provide gravimetric Huptake around 1.63 wt. % for Zn—Cu-BTC, around 1.61 wt. % for Ni—Cu-BTC, around 1.63 wt. % for Fe—Cu-BTC, and around 1.12 wt. % for Co—Cu-BTC. 1. A mixed-metal metal organic framework (MM-MOF) , comprising:a linker comprising, relative to a total linker weight, at least 75 wt. % of 1,3,5-benzenetricarboxylate bound into the MM-MOF; and{'sup': 2+', '2+', '2+', '2+', '2+, 'divalent metal cations comprising, relative to a total metal weight, at least 65 atom. % Cu and from 10 to 30 atom. % of Ni Zn, Co, and/or Fe, bound into the MM-MOF,'}{'sup': '2+', 'wherein the MM-MOF has a gradient in Cu concentration between a center of the MM-MOF and an outer perimeter of the MM-MOF, and'}{'sup': '2+', 'wherein concentration of the Cu is higher towards the center of the MM-MOF than the outer perimeter.'}2. The MM-MOF of claim 1 , which is crystalline by powder x-ray diffraction and has a TBO topology.3. The MM-MOF of claim 1 , comprising the Ni in a range of from 10 to 30 atom. % claim 1 , and a remainder of the Cu.4. The MM-MOF of claim 1 , comprising the Zn in a range of from 10 to 20 atom. % claim 1 , and a remainder of the Cu.5. The MM-MOF of claim 1 , comprising the Co in a range of from 12.5 to 25 atom. % claim 1 , and a remainder of the Cu.6. The MM-MOF of claim 1 , comprising the Fe in a range of from 12 to 22.5 atom. % claim 1 , and a remainder of the Cu.7. The MM-MOF of claim 1 , wherein the Cu gradient is produced by a process comprising solution-based diffusion of the Ni claim 1 , Zn claim 1 , Co claim 1 , and/or Fe claim 1 , into a preexisting MOF comprising the Cu and the 1 claim 1 ,3 claim 1 ,5-benzenetricarboxylate.8 ...

Metal Delivery Agents and Therapeutic Uses of the Same

The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type. 191.-. (canceled)93. The method of where the disease is Parkinson's disease.94. The method of where the disease is amyotrophic lateral sclerosis.95. The method of where M is Cu.96. The method of where M is Zn.97. The method of where R2 and R6 are each methyl.98. The method of where R2 and R6 are each ethyl.99. The method of where R2 and R6 are each phenyl.100. The method of where M is Cu and R2 and R6 are each methyl.101. The method of where M is Cu and R2 and R6 are each ethyl.102. The method of where M is Cu and R2 and R6 are each phenyl.103. The method of where M is Zn and R2 and R6 are each methyl.104. The method of where M is Zn and R2 and R6 are each ethyl.105. The method of where M is Zn and R2 and R6 are each phenyl.106. The method of where M is Cu and R2 and R6 are each methyl.107. The method of where M is Cu and R2 and R6 are each ethyl.108. The method of where M is Cu and R2 and R6 are each phenyl.109. The method of where M is Zn and R2 and R6 are each methyl.110. The method of where M is Zn and R2 and R6 are each ethyl.111. The method of where M is Zn and R2 and R6 are each phenyl. The present invention relates to the use of metal complexes as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal ...

Organic electroluminescent materials and devices

A compound having a structure according to formula (I) is disclosed. In formula (I), Cu is a monovalent copper atom; *C is a carbene carbon; X 1 and X 2 are selected from alkyl, cycloalkyl, alkoxy, amino, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof; X 1 and X 2 are independently bonded to *C by an atom selected from C, N, O, S, and P; X 1 and X 2 are optionally joined to form a ring; and Y is selected halide, alkyl, cycloalkyl, alkoxy, amino, phosphine, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, heteroalkynyl, arylalkyl, aryloxy, aryl, heteroalkyl, heteroaryl, and combinations thereof. A formulation containing compound having a structure according to formula (I), and a device with an organic layer comprising disposed between an anode and a cathode, that includes a compound having a structure according to formula (I) are also described.

A POLYMER COATED METAL-ORGANIC FRAMEWORK

The present invention relates to metal-organic framework characterized in that it comprises a polymer coating; further the invention relates to a process for the preparation of said polymer-coated metal-organic framework and a process for recycling after degradation. The polymer coated MOFs of this invention find application in a broad range of technologies and therapeutic areas. 1. A metal-organic framework characterized in that it comprises a polymer coating.2. The metal-organic framework of claim 1 , wherein the metal-organic framework comprises one or more metal ions or metal clusters and one or more organic linkers claim 1 , the metal ions or metal clusters being of any metal selected from the periodic table claim 1 , preferably a metal from group IIA claim 1 , IIIA claim 1 , first row transition metals claim 1 , second row transition metals claim 1 , actinides claim 1 , and lanthanides.3. The metal-organic framework of claim 2 , wherein the organic linkers are small organic molecules with two or more coordinating functional groups.4. The metal-organic framework of claim 1 , wherein the BET surface area ranges from 10 m/g to 7000 m/g.5. The metal-organic framework of claim 1 , wherein the pore size ranges from 0.3 nm to 10 nm.6. The metal-organic framework of claim 1 , wherein the polymer coating is selected from styrene claim 1 , acrylate claim 1 , and methacrylate polymer coatings claim 1 , and further from polyimide claim 1 , polysulfone claim 1 , polyethersulfone claim 1 , and polyamide polymer coatings.7. The metal-organic framework of claim 1 , wherein the polymer coating has a thickness of from 1 nm to 1 μm.8. (canceled)9. A process for the preparation of a metal-organic framework comprising a polymer coating claim 1 , a controlled radical polymerization step.10. A process for recycling of degraded polymer-coated metal-organic frameworks claim 1 , comprising vapor or liquid assisted annealing or a solvothermal reaction. The present invention relates to a ...

COMPOSITION OF MATTER

The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding allylic substrates and substituted hydroxylamines, in the presence of a catalyst, said catalyst comprising copper compounds and a chiral ligand. Examples of chiral amine compounds which can be made using the method include Vigabatrin, Ezetimibe Terbinafine, Naftifine 3-methylmorphine, Sertraline, Cinacalcet, Mefloquine hydrochloride, and Rivastigmine. There are over 20,000 known bioactive molecules with chiral N-substituted allylic amine substructure. The method may also be used to produce non-natural chiral 13-aminoacid esters, a sub-class of chiral N-substituted allylic amine compounds. Examples of 13-aminoacid ester which can be produced by the disclosed method, include, but are not limited to, N-(2-methylpent--en-3-yl)benzenamine and Ethyl 2-methylene-3-(phenylamino)butanoate. Further, the products of the method described herein can be used to produce chiral heterocycles and bioactive molecules or materials. A novel chiral copper-BINAM nitrosoarene complex is also set forth. 1. A chemical compound comprising:a. a copper atom;b. two nitrosoarenes;c. two nitrogen donor ligands; andd. two counterions.2. The chemical compound of wherein the compound is a chiral coppernitrosoarene complex.3. The chemical compound of wherein at least one ligand is chiral.4. The chemical compound of wherein the copper atom is bonded to two chiral nitrogen-donor ligands claim 1 , such as BINAM claim 1 , NOBIN claim 1 , and related substituted ligands.5. The chemical compound of wherein the copper atom is bonded to two nitrosoarenes claim 1 , such as nitrosobenzene claim 1 , and related substituted nitrosobenzenes.6. The chemical compound of wherein the copper complex is associated with at least one counter ion such as triflates or halides.7. The chemical compound synthesized from the process of combining copper (II) salt [Cu(X)2] ...

SYNTHESIS OF TETRAZOLATE SALTS

The present invention relates to a novel method of synthesis of copper (I) 5-nitrotetrazolate. Particularly, for the synthesis of the copper (I) 5-nitrotetrazolate, the present invention uses a suitable salt of 5-aminotetrazole, preferably the sulfate or the nitrate salt as the starting compound. The selection of the said starting chemical not only eliminates any safety issue arising during Sandmeyer reaction conditions to affect the functional group conversion but also greatly improves the ease of executing the synthetic protocol, rendering the process safe to be adopted for commercial manufacture of the copper (I) 5-nitrotetrazolate compound. 1. A method of synthesis of copper (I) 5-nitrotetrazolate , the method comprises:a) using a salt of 5-aminotetrazole as a starting compound for the synthesis of the copper (I) 5-nitrotetrazolate;{'sub': '2', 'b) adding an acid to an aqueous mixture comprising of (i) the salt of 5-aminotetrazole, (ii) sodium nitrite (NaNO) and (iii) a copper salt or its hydrated form, at a suitable temperature to form a reaction mixture;'}c) stirring and heating the reaction mixture to form 5-nitrotetrazole in situ;d) adding an aqueous solution of sodium hydroxide (NaOH) to the reaction mixture at a particular temperature to convert 5-nitrotetrazole formed in step (c) to its sodium salt in situ, and a precipitated dark compound;e) filtering off the precipitated dark compound formed in step (d) to obtain a filtrate containing the said sodium salt of 5-nitrotetrazole;f) heating the filtrate containing the sodium salt of 5-nitrotetrazole to a particular temperature followed by addition of cuprous chloride (CuCl) to the filtrate until a colored solid is precipitated out of the reaction mixture;g) filtering the precipitated colored solid after removing all impurities, washing the precipitated solid successively with hot water and alcohol, and drying the precipitated colored solid to obtain the copper (I) 5-nitrotetrazolate.2. The method as claimed ...

PRODUCTION OF METAL-ORGANIC FRAMEWORKS

An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop. 1. A process for producing metal organic frameworks , the process comprising:mixing at least two different precursor solutions for forming the metal organic framework (MOF) through inline mixing to form a solution mixture, the precursor solutions comprising a first precursor solution comprising at least one multidentate linking ligand in water; and a second precursor solution comprising a metal cluster or metallic salt thereof in water,introducing the solution mixture into an apparatus which comprises: a tubular flow reactor which comprises a tubular body having an inlet into which, in use, the solution mixture is fed and flows, said tubular body including at least one annular loop comprising a coil; andpromoting a reaction within the tubular flow reactor to form the metal organic framework,wherein the precursor solutions are mixed through inline mixing in a feed conduit fluidly connected to the inlet of the tubular body and the resulting solution mixture being fed into said inlet,and wherein the solution mixture flows through said tubular body mixing the precursor compounds therein to produce the metal organic frameworks.2. The process according to claim 1 , wherein the two or more precursor solutions are mixed at or proximate said inlet.3. The process according to claim 2 , wherein the apparatus further comprises an inline mixer located at or proximate the inlet to the tubular body claim 2 , the inline mixer mixing the precursor solutions through inline mixing in said feed conduit fluidly connected to the inlet of the tubular body.4. The process according to claim 1 , wherein the apparatus further comprises a flow restriction device comprising a back-pressure controller downstream of the tubular reactor ...

Copper Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand. 2. The method of claim 1 , further comprising (2) combining an ionic activator with the reaction product.43. The method of claim 1 , further comprising (2) combining an ionic activator with the reaction product.6. The method of claim 5 , further comprising (2) combining a reducing agent with the reaction product.8. The method of claim 7 , further comprising (2) combining a reducing agent with the reaction product.9. The method of claim 1 , where one of conditions (i)-(v) is satisfied:(i) each A is a monovalent hydrocarbon group; or(ii) each A is an aryl group or an aralkyl group; or(iii) each A is mesityl; or(iv) each A is a silyl amide; or(v) each A is bis trimethylsilyl amide.10. (canceled)11. (canceled)12. (canceled)13. A composition comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, '(A) a catalytically active reaction product prepared by the method of ;'}(B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction; and(C) a polyorganohydrogensiloxane.14. A composition comprising:{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, '(A) a catalytically active reaction product prepared by the method of ;'}(B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction; and{'sup': 4', '4, 'sub': e', 'f, '(C) a silane ...

Labeled Alginate Conjugates For Molecular Imaging Applications

Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents. 2. The compound of claim 1 , wherein the compound further comprises a stable or radioactive metal ion chelated by the 1 claim 1 ,4 claim 1 ,7-triazacyclononane-1 claim 1 ,4 claim 1 ,7-triacetic acid moiety.3. The compound of claim 2 , wherein the stable or radioactive metal ion comprises a gallium ion.4. The compound of claim 2 , wherein the radioactive metal ion comprises Cu claim 2 , Cu claim 2 , Cu claim 2 , Cu claim 2 , Cu claim 2 , or In. This application is a divisional of U.S. patent application Ser. No. 13/708,306, filed Dec. 7, 2012, which claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Application No. 61/568,796, filed Dec. 9, 2011, the entire contents of which are incorporated herein by reference in their entireties.The present invention generally relates to the field of alginate conjugates and their use as imaging reagents.Cross-linked polymer hydrogel materials are widely utilized in the biomedical industry. They are used in contact lenses, blood contact materials, controlled release formulations, wound dressings, bioadhesives, membranes, superabsorbents, cell encapsulation and immunoisolation materials, and tissue engineering scaffolds. Among the different polymers, the naturally occurring polysaccharide alginic acid has found biomedical applications because of its biocompatibility, relative biological inertness, and the ability to engineer its mechanical properties by introducing various types of chemical and physical crosslinks. Alginic acid distinguishes itself from other biologically occurring polysaccharides in its ...

THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF

Provided, inter alia, are thiosemicarbazone compounds, metal complexes of thiosemicarbazone compounds, pharmaceutical compositions, and methods for treating cancer. 3. The compound of claim 2 , wherein the electronegative moiety is halogen claim 2 , —NH claim 2 , or an alkylamine.11. A pharmaceutical composition comprising the compound of and a pharmaceutically acceptable excipient.12. A composition comprising: (i) the compound of claim 1 , and (ii) copper claim 1 , a copper salt claim 1 , zinc claim 1 , a zinc salt claim 1 , cobalt claim 1 , a cobalt salt claim 1 , nickel claim 1 , a nickel salt claim 1 , magnesium claim 1 , a magnesium salt claim 1 , iron claim 1 , an iron salt claim 1 , manganese claim 1 , a manganese salt claim 1 , gallium claim 1 , a gallium salt claim 1 , germanium claim 1 , a germanium salt claim 1 , calcium claim 1 , a calcium salt claim 1 , or a combination of two or more thereof.13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. A method of treating cancer in a subject in need thereof claim 1 , the method comprising administering to the subject a therapeutically effective amount of the compound of .18. (canceled)19. (canceled)20. (canceled)21. (canceled)22. (canceled)23. (canceled)24. (canceled)27. (canceled)28. (canceled)29. (canceled)30. (canceled)31. (canceled)32. (canceled)33. (canceled)34. (canceled)35. (canceled)36. (canceled)38. (canceled)39. (canceled)40. (canceled)41. (canceled)42. (canceled)43. (canceled)44. (canceled)45. (canceled)46. (canceled)47. (canceled)48. (canceled)51. A pharmaceutical composition comprising the compound of and a pharmaceutically acceptable excipient.52. A method of treating cancer in a subject in need thereof claim 25 , the method comprising administering to the subject a therapeutically effective amount of the compound of .53. (canceled)54. (canceled)55. (canceled)56. (canceled)57. (canceled)58. (canceled)59. (canceled) This application claims priority to U.S. Application No. 62/810,160 filed ...

METHOD FOR PREPARING, IN SITU, METAL-ORGANIC FRAMEWORK BY USING CONTROL OF DIFFUSION WITHIN IONIC POLYMER

Disclosed is a method for preparing a matrix containing metal-organic frameworks (MOFs), comprising the steps of: 1) mixing an organic ligand precursor solution and an anionic polymer-containing solution to produce a mixed solution; and 2) adding a metal salt to the mixture solution. In addition, the present disclosure provides a matrix containing MOFs prepared according to the preparation method, and an adsorbent comprising the same. Furthermore, a method for performing fluid separation by using a matrix containing MOFs prepared according to the preparation method is disclosed. 1. A method for preparing a matrix containing metal-organic frameworks (MOFs) , the method comprising steps of:1) mixing an organic ligand precursor solution and an anionic polymer-containing solution to produce a mixed solution; and2) adding a metal salt to the mixed solution.2. The method of claim 1 , wherein step 1) further comprises step 1-1) of adding a crosslinkable metal salt to the mixed solution.3. The method of claim 1 , further comprising claim 1 , before step 1):step 1-0) of mixing the anionic polymer and a flexible polymer to produce an anionic polymer-containing solution.4. The method of claim 1 , wherein the MOFs contained in the matrix are uniformly distributed in the matrix.5. The method of claim 1 , wherein the MOFs have windows formed inside the MOFs wherein the windows have a uniform window size.6. The method of claim 1 , wherein the matrix comprises 10 to 50% by weight (wt %) of MOFs based on the total weight of the matrix.7. The method of claim 1 , wherein the anionic polymer is at least one selected from the group consisting of alginate claim 1 , carboxymethyl cellulose claim 1 , hyaluronic acid claim 1 , poly(acrylic acid) (PA) and its derivatives claim 1 , poly(methyl acrylate) (PMA) and its derivatives claim 1 , poly(thiophene acetic acid) and its derivatives claim 1 , poly(sulfonate styrene) (PSS) and its derivatives claim 1 , and a combination thereof.8. The ...

METAL COMPLEX, AND ABSORBENT MATERIAL, STORAGE MATERIAL AND SEPARATION MATERIAL COMPRISING METAL COMPLEX

The metal complex comprises a multivalent carboxylic acid compound, at least one metal ion selected from ions of metals belonging to Groups 2 to 13 of the periodic table, an organic ligand capable of multidentate binding to the metal ion, and a Cor Cmonocarboxylic acid compound. The metal complex has excellent gas adsorption, storage, and separation performance as well as excellent durability. The metal complex is stably present under high temperature and high humidity, and can maintain high adsorption performance. 1. A metal complex comprising:a multivalent carboxylic acid compound,at least one metal ion, which is an ion of a metal of Groups 2 to 13 of the periodic table,an organic ligand capable of multidentate binding to the metal ion, and{'sub': 1', '2, 'a Cor Cmonocarboxylic acid compound,'}wherein a composition ratio of the multivalent carboxylic acid compound to the monocarboxylic acid compound is from 10:1 to 5,000:1.2. The metal complex according to claim 1 , wherein the multivalent carboxylic acid compound is a dicarboxylic acid compound.3. The metal complex according to claim 1 , wherein the organic ligand capable of multidentate binding is an organic ligand capable of bidentate binding.4. The metal complex according to claim 3 , wherein the organic ligand capable of bidentate binding has a longitudinal length of 7.0 Å or more and 16.0 Å or less.5. The metal complex according to claim 1 , wherein the metal complex is molded into any shape selected from the group consisting of a pellet claim 1 , a film claim 1 , a sheet claim 1 , a plate claim 1 , a pipe claim 1 , a tube claim 1 , a rod claim 1 , a granule claim 1 , a special molded product claim 1 , a fiber claim 1 , a hollow filament claim 1 , a woven fabric claim 1 , a knitted fabric claim 1 , and a non-woven fabric.6. An adsorbent material claim 1 , comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the metal complex according to .'}7. The adsorbent material according to claim 6 , which is a ...

Silver Containing Hydrosilylation Catalysts And Compositions Containing The Catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition ′ capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand. 2. (canceled)3. (canceled)4. The method of claim 1 , further comprising (2) combining the reaction product with a reducing agent.6. The method of claim 5 , further comprising (2) combining the reaction product with an ionic activator.7. The method of claim 4 , where the reaction product comprises an Ag-ligand complex and a by-product of reaction of the Ag precursor and the ligand or of a side reaction therein.8. The method of claim 7 , further comprising removing all or a portion of the by-product.9. The method of claim 4 , further comprising using the product prepared by the method as a hydrosilylation catalyst.10. A composition comprising:{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, '(A) a catalytically active reaction product prepared by the method of ;'}(B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction; and{'sup': 4', '4, 'sub': e', 'f, '(C) a silane of formula RSiH, where subscript e is 0, 1, 2, or 3; subscript f is 1, 2, 3, or 4, with the proviso that a sum of (e+f) is 4, and each Ris independently a halogen atom or a monovalent organic group.'}11. The composition of claim 10 , where the composition further comprises one or more additional ingredients claim 10 , which are distinct from ingredients (A) claim 10 , (B) claim 10 , and (C) claim 10 , and which are selected from the group consisting of (D) a spacer; (E) ...

SELECTIVE EXTRACTION OF ANIONS FROM SOLUTION

A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper contributor, a hydroxide contributor, an optional counterion contributor, and at least one encapsulating anion to an aqueous solution containing the anions, or upon the addition of a solvent, a polymeric chain of [Cu(μ-OH)(μ-ea)] and optionally, a counterion contributor to the aqueous solution. The aggregates include compounds of the formula cis-Cu(OR)(Rea), where Ris H or an alkyl group, Ris H, or an alkyl group or a charged group, ea is an encapsulating anion, and each of x, y, and z is equal to an integer between about 1 and 40, inclusive. In addition, anion encapsulating aggregates can be formed by synthesis with alternate encapsulating anions by substituting alternate encapsulating anions for the encapsulating anion incorporated in the aggregate. 1. An anion-encapsulating compound , comprising:{'sup': 'II', 'sub': x', '1', 'y', '2', '1', '3', '2', '5', '3', '7', '4', '9', '2', '3', '2', '5', '3', '7', '4', '9, 'an encapsulating host of the formula cis-Cu(OR)(Rea) where Ris H, CH, CH, CH, CHor another alkyl group, Ris H, CH, CH, CH, CHor another alkyl or charged group, ea is a first encapsulating anion having a core with two donor atoms on one side at 1.3 angstroms to 2.5 angstroms apart, with no other atoms substantially hindering the coordination of the donor atoms to the copper metal centers, and each of x, y, and z is equal to an integer between about 1 and 40, inclusive.'}2. The anion encapsulating compound of claim 1 , wherein the first encapsulating anion is a pyrazolate anion claim 1 , a methyl pyrazolate anion claim 1 , a ligand-bound pyrazolate anion claim 1 , an ethylene-bridged pyrazolate claim 1 , or an indazolate anion.3. The anion encapsulating compound of claim 1 , comprising:a mixture of encapsulating anions, wherein the first encapsulating anion has a core with two donor atoms on one side at 1 ...

MULTIFUNCTIONAL SUPRAMOLECULAR HYBRIDS ENCOMPASSING HIERARCHICAL SELF-ORDERING OF METAL-ORGANIC FRAMEWORK NANOPARTICLES AND METHOD OF PREPARING SAME

A supramolecular metal-organic framework material is a reaction product of a copper compound, a trialkylamine represented by Chemical Formula 1, and benzene substituted with 3 or more carboxyl groups. 2. The supramolecular metal-organic framework material of claim 1 , wherein the copper compound is copper nitrate (Cu(NO)) claim 1 , the trialkylamine represented by the Chemical Formula 1 is triethylamine (NEt) claim 1 , and the benzene substituted with 3 or more carboxyl groups is 1 claim 1 ,3 claim 1 ,5-benzenetricarboxylic acid (BTC).3. The supramolecular metal-organic framework material of claim 1 , wherein the reaction product is obtained in a non-aqueous organic solvent.4. The supramolecular metal-organic framework material of claim 3 , wherein the non-aqueous organic solvent includes one of a C-Calkanol claim 3 , dimethyl sulfoxide (DMSO) claim 3 , N claim 3 ,N-dimethyl formamide (DMF) claim 3 , N claim 3 ,N-diethylformamide (DEF) claim 3 , N claim 3 ,N-dimethylacetimide (DMAc) claim 3 , acetonitrile (ACN) claim 3 , toluene claim 3 , dioxane claim 3 , chlorobenzene claim 3 , methylethylketone (MEK) claim 3 , pyridine claim 3 , and a combination thereof.5. The supramolecular metal-organic framework material of claim 1 , wherein the supramolecular metal-organic framework material is in a sol state.6. The supramolecular metal-organic framework material of claim 1 , wherein the supramolecular metal-organic framework material is in a gel state.7. The supramolecular metal-organic framework material of claim 1 , wherein the supramolecular metal-organic framework material is a viscoelastic material.8. The supramolecular metal-organic framework material of claim 1 , wherein the supramolecular metal-organic framework material has a nanoparticle shape.9. The supramolecular metal-organic framework material of claim 1 , wherein the supramolecular metal-organic framework material has a lamella structure.11. The method of claim 10 , wherein the copper compound is copper ...

CHLOROBIS COPPER (I) COMPLEX COMPOSITIONS AND METHODS OF MANUFACTURE AND USE

A method of manufacturing an anhydrous copper complex of formula CHCICuNOand methods of treating neur-muscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention. 1. A method of treating a disease selected from the group consisting of: fibromyalgia , multiple sclerosis , muscular dystrophy , rheumatoid arthritis , Alzheimer's , dementia , amyotrophic lateral sclerosis , depression , joint pain , muscle pain , fatigue , sleeplessness , loss of fine motor control , speech loss , inflexibility , lyme disease , lyme disease co-infection , gastroparesis (GP) , myopathy , chronic inflammation , stroke , joint pain , muscle pain , fatigue , sleeplessness , inflexibility , myopathy , incontinence , impaired fine motor skills , high cholesterol , low sperm count , obesity , alopecia , burns , stretch marks , scars , attention deficit disorder , attention deficit hyperactivity disorder , and erectile dysfunction and incontinence , comprising administering to an animal in need of such treatment a copper complex of formula CHClCuNO.2. (canceled)3. The method of claim 1 , wherein the animal is a human being and the copper complex is administered sublingually.45-. (canceled)7. The method of claim 3 , wherein the compound is administered in a dose between 1 mg and 20 mg per day.8. The method claim 7 , wherein the compound is administered in a dose between 5 mg and 10 mg per day.912-. (canceled)13. A method of making an anhydrous copper complex claim 7 , comprising the steps of:a) adding an effective amount of nicotinic ...

CARBENE COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICES

A compound selected from the group consisting of Formula I, Formula II, and Formula III, 2. The compound of claim 1 , wherein L is selected from the group consisting of: NRR claim 1 , PRR claim 1 , CRRR claim 1 , substituted phenyl claim 1 , OR claim 1 , and SR claim 1 ,{'sup': X', 'Y', 'Z', 'X', 'Y, 'wherein R, R, and Rare independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, and combinations thereof; each of which is optionally substituted, or optionally, Rand Rcan join to form five-membered or six-membered, carbocyclic or heterocyclic ring, which is optionally substituted.'}3. The compound of claim 1 , wherein ring B is selected from the group consisting of:an optionally substituted cycloalkyl with 5 to 10 carbons;an optionally substituted aryl with 6 to 10 carbons;an optionally substituted heterocyclic with 3 to 8 carbons and 1 to 3 heteroatoms; andan optionally substituted heteroaryl with 3 to 8 carbons and 1 to 4 heteroatoms.4. The compounds of claim 1 , wherein ring A and/or ring B is a 2 claim 1 ,6-disubstituted phenyl or an aza-derivative thereof claim 1 , wherein C1 is connected to the nitrogen of the ring W.6. The compound of claim 5 , wherein T is selected from O or CRR.7. The compound of claim 5 , wherein R claim 5 , R claim 5 , R claim 5 , R claim 5 , R claim 5 , and Rare independently selected from the group consisting of hydrogen claim 5 , deuterium claim 5 , alkyl claim 5 , cycloalkyl claim 5 , heteroalkyl claim 5 , aryl claim 5 , heteroaryl claim 5 , and combinations thereof; or optionally claim 5 , Rjoins with Rto form a ring claim 5 , or two Rjoin to form a ring claim 5 , each of which is optionally substituted.9. The compound of claim 2 , wherein Rand/or Ris selected from the group consisting of:an aryl, optionally substituted with deuterium, alkyl, or an electron donating substituent group,a heteroaryl, optionally substituted with deuterium, alkyl, or an ...

METAL-ORGANIC FRAMEWORKS

The present invention relates to metal-organic frameworks and, in particular, a continuous flow process for synthesising a metal-organic framework comprising the steps of: providing a ligand and a metal salt which are suitable for forming a metal-organic framework, mixing the ligand and metal salt with a solvent to form a mixture, and providing the mixture at a temperature sufficient to cause the ligand and the metal salt to react to form a metal-organic framework. The invention also relates to a method for the treatment of a metal-organic framework to extract unreacted ligand from the metal organic framework, a method for synthesising a metal-organic framework using recycled unreacted ligand, and uses for metal-organic frameworks. 1. A continuous flow process for synthesising a metal-organic framework comprising the steps of:a. providing a ligand and a metal salt which are suitable for forming a metal-organic framework,b. mixing the ligand, metal salt and, optionally, other reagents with a solvent to form a mixture, andc. providing the mixture at a temperature sufficient to cause the ligand and the metal salt to react to form a metal-organic framework.2. The continuous flow process according to wherein the solvent is preheated to a temperature sufficient to cause the ligand to react with the metal salt to form a metal-organic framework.3. The continuous flow process according to wherein the preheated solvent is a supercritical fluid or near critical fluid.4. The continuous flow process according to wherein the preheated solvent is at a temperature of at least about 200° C.5. The continuous flow process according to wherein the preheated solvent is at a pressure of at least about 1.55 MPa.6. The continuous flow process according to wherein the mixture is at a temperature of at least about 150° C. claim 1 , preferably at least 200° C.7. The continuous flow process according to wherein mixture comprises supercritical or near critical solvent.8. The continuous flow ...

Method of preparing metal complexes of formula Z-M, in particular carbene-metal complexes

The present invention relates to an improved method of preparing metal complexes, in particular carbene-metal complexes. The method comprises the step of subjecting a salt of formula Z—X and a non-ionic metal salt of formula MLor subjecting a metallate of formula Z . . . MLX to a mechanical mixing process in the presence of a base. The method allows to formation of heterocyclic carbene metal complexes such as a nitrogen-containing heterocyclic carbene (NHC)-metal complexes. The invention also relates to the use of metal complexes, in particular carbene-metal complexes such as heterocyclic carbene-metal complexes obtainable by the method according to the present invention as catalysts. 1. A method of preparing a metal complex of formula Z-M , the method comprising the steps of{'sup': +', '−, 'sub': 'n', 'i1) providing a salt of formula Z—X and a non-ionic metal salt of formula ML; or'}{'sup': +', '−, 'sub': 'n', 'claim-text': with', 'Z comprising a two-electron donor ligand;', 'X comprising an anion;', 'M comprising a metal;', 'L comprising an anion or an electron donor ligand;', 'and, 'i2) providing a metallate of formula Z. . . MLX,'}{'sup': +', '−', '+', '−, 'sub': 'n', 'ii) subjecting the salt of formula Z—X and the metal salt of formula ML of step i1) or the metallate of formula Z. . . MLX, of step i2) to a mechanical mixing process in the presence of a base to form said metal complex of formula Z-M.'}2. The method according to claim 1 , wherein said method does not require the use of a solvent.3. The method according to claim 1 , wherein said salt of formula Z—X of step i1) has a single two-electron donor ligand Z or wherein said metallate of formula Z. . . MLX of step i2) has a single two-electron donor ligand Z.4. The method according to claim 1 , wherein said non-ionic metal salt of formula ML comprises a single metal M.5. The method according to claim 1 , wherein said metal complex of formula Z-M has a single two-electron donor ligand Z.6. The method ...

METHOD OF MAKING ORGANIC ELECTROLUMINESCENT MATERIALS

A method of forming compounds that comprise a heterocyclic carbene ligand is provided. In particular, an oxazole or a thioazole carbene are used in place of the traditional imidazole carbene. These compounds may be used in OLEDs to provide devices having improved properties, such as stability and color-tuning. 2. The compound of claim 1 , wherein A is benzene.5. The compound of claim 1 , wherein the compound is heteroleptic.6. The compound of claim 1 , wherein the compound is homoleptic.12. The first device of claim 11 , wherein the organic layer is an emissive layer and the compound is an emissive dopant.13. The first device of claim 11 , wherein the organic layer further comprises a host.15. The first device of claim 13 , wherein the host is a metal complex.17. A process for making a carbene metal complex claim 13 , comprising:reacting a copper dichloride carbene dimer with a metal precursor to yield the carbene metal complex.18. The process of claim 17 , further comprising reacting a carbene salt with copper-t-butoxide to yield a copper dichloride carbene dimer claim 17 , prior to reacting the copper dichloride carbene dimer with the metal precursor.19. The process of claim 17 , wherein the metal is Ir claim 17 , Os claim 17 , Ru or Pt.20. The process of claim 19 , wherein the metal precursor is selected from the group consisting of [IrCl(COD)] claim 19 , OsCl(DMSO) claim 19 , RuCl(DMSO) claim 19 , and PtCl(SEt). This application is a divisional application of U.S. patent application Ser. No. 13/033,287, filed Feb. 23, 2011, the entirety of which is incorporated herein by reference.The claimed invention was made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: Regents of the University of Michigan, Princeton University, University of Southern California, and Universal Display Corporation. The agreement was in effect on and before the date the claimed invention was made, and the ...

ANTIMICROBIAL COMPOSITE MATERIAL AND METHOD FOR FABRICATING THE SAME

An antimicrobial composite material and a method for fabricating the same are provided. The antimicrobial composite material includes a porous material, a chelating agent, and a multivalent metal ion. The chelating agent is chemically bonded to the porous material, and the multivalent metal ion is chemically bonded to the chelating agent. 1. An antimicrobial composite material , comprising:a porous material;a chelating agent chemically bonded to the porous material; anda multivalent metal ion chemically bonded to the chelating agent.2. The antimicrobial composite material as claimed in claim 1 , wherein a molar ratio of the multivalent metal ion to the chelating agent is 0.5:1 to 20:1.3. The antimicrobial composite material as claimed in claim 1 , wherein the multivalent metal ion comprises divalent silver ion (Ag) claim 1 , trivalent silver ion (Ag) claim 1 , trivalent cobalt ion (Co) claim 1 , trivalent nickel ion (Ni) or a combination thereof.4. The antimicrobial composite material as claimed in claim 3 , wherein a molar ratio of the multivalent metal ion to the chelating agent is 0.5:1 to 10:1 when the multivalent metal ion is divalent silver ion (Ag) claim 3 , trivalent silver ion (Ag) or a combination thereof.5. The antimicrobial composite material as claimed in claim 3 , wherein a molar ratio of the multivalent metal ion to the chelating agent is 1:1 to 20:1 when the multivalent metal ion is trivalent cobalt ion (Co) claim 3 , trivalent nickel ion (Ni) or a combination thereof.6. The antimicrobial composite material as claimed in claim 1 , wherein the antimicrobial composite material comprises 10 wt % to 50 wt % of the multivalent metal ion.7. The antimicrobial composite material as claimed in claim 1 , wherein a molar ratio of the porous material to a sum of the chelating agent and the multivalent metal ion is 1:0.5 to 1:20.8. The antimicrobial composite material as claimed in claim 1 , wherein the chelating agent comprises ethylene diamine tetra acetic acid ...

COORDINATION POLYMERS OF COINAGE METALS SYNTHESIS AND USES THEREOF

The embodiments described herein pertains to a new design method to produce copper, silver or gold based metal functional coordination polymers with excellent potential towards optoelectronic devices, gas storage and separation, optical sensors, and other applications. 1. A coordination polymer comprising:at least one metal atom selected from the group consisting of copper, silver, and gold; andat least one neutral bridging electron-donor organic ligand and/or a negatively-charged counterion.2. The coordination polymer of claim 1 , wherein the coordination polymer comprises an anionic ligand.3. The coordination polymer of claim 1 , wherein the coordination polymer comprises an anionic counterion.4. The coordination polymer of claim 1 , wherein the coordination polymer is a polymer having repeat units of the structure (I):{'br': None, 'sub': 1', '1', '1', '1', '2', '2', '2', '2, '-{M(X{circumflex over (\u2003)}{circumflex over (\u2003)}{circumflex over (\u2003)}Y)n}{M(X{circumflex over (\u2003)}{circumflex over (\u2003)}{circumflex over (\u2003)}Y)n}-\u2003\u2003 (I)'}where:{'sub': 1', '2, 'Mand Mare each, independently, copper, silver, or gold;'}{'sub': 1', '2', '1', '2, 'X, X, Y, and Yare each, independently N, O, P, or S;'}{'sub': 1', '1', '2', '2, 'each {circumflex over (\u2003)}{circumflex over (\u2003)}{circumflex over (\u2003)} represents, independently, an alkyl or aryl hydrocarbon group linking the respective groups X/Yand X/Ytogether; and'}{'sub': 1', '2', '1', '2, 'n+n=the coordination number of M+the coordination number of M.'}5. The coordination polymer of claim 1 , wherein the coordination polymer is a polymer having repeat units of the structure (II):{'br': None, 'sub': 1', '1', '1', '1', '2', '2', '2', '2', '1', '3', '2', '4, '-{[M(X{circumflex over (\u2003)}{circumflex over (\u2003)}{circumflex over (\u2003)}Y)nM(X{circumflex over (\u2003)}{circumflex over (\u2003)}{circumflex over (\u2003)}Y)n][Z]n[Z]n}-\u2003\u2003 (II)'}where:{'sub': 1', '2, 'Mand ...

PRODUCTION OF METAL-ORGANIC FRAMEWORKS

An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop. 1. A process for producing metal organic frameworks , the process comprising:mixing at least two different precursor solutions for forming the metal organic framework (MOF) through inline mixing to form a solution mixture, the precursor solutions comprising a first precursor solution comprising at least one multidentate linking ligand in solvent; and a second precursor solution comprising a metal cluster or metallic salt thereof in solvent,introducing the solution mixture into an apparatus which comprises: a tubular flow reactor which comprises a tubular body having an inlet into which, in use, the solution mixture is fed and flows, said tubular body including at least one annular loop comprising a coil; and a flow restriction device comprising a back-pressure controller downstream of the tubular reactor for controlling the pressure within the tubular reactor, andpromoting a reaction within the tubular flow reactor to form the metal organic framework,wherein the precursor solutions are mixed through inline mixing in a feed conduit fluidly connected to the inlet of the tubular body and the resulting solution mixture being fed into said inlet at room temperature, the two or more precursor solutions being mixed at or proximate said inlet,and wherein the solution mixture flows through said tubular body mixing the precursor compounds therein to produce the metal organic frameworks.2. The process according to claim 1 , wherein the apparatus further comprises an inline mixer located at or proximate the inlet to the tubular body claim 1 , the inline mixer mixing the precursor solutions through inline mixing in said feed conduit fluidly connected to the inlet of the tubular body.3. The process according to claim 1 ...

CHIRAL N-SUBSTITUTED ALLYLIC AMINE COMPOUNDS

The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding allylic substrates and substituted hydroxylamines, in the presence of a catalyst, said catalyst comprising copper compounds and a chiral ligand. Examples of chiral amine compounds which can be made using the method include Vigabatrin, Ezetimibe Terbinafine, Naftifine 3-methylmorphine, Sertraline, Cinacalcet, Mefloquine hydrochloride, and Rivastigmine. There are over 20,000 known bioactive molecules with chiral N-substituted allylic amine substructure. The method may also be used to produce non-natural chiral β-aminoacid esters, a sub-class of chiral N-substituted allylic amine compounds. Examples of β-aminoacid ester which can be produced by the disclosed method, include, but are not limited to, N-(2-methylpent-1-en-3-yl)benzenamine and Ethyl 2-methylene-3-(phenylamino)butanoate. Further, the products of the method described herein can be used to produce chiral heterocycles and bioactive molecules or materials. A novel chiral copper-BINAM nitrosoarene complex is also set forth. 1. The isolated chemical compound synthesized from the process of combining copper (II) salt [Cu(X)2] , and chiral nitrogen donor ligand in the presence of toluene.2. The isolated chemical compound of wherein the process comprises the steps of reacting Cu(X)2 claim 2 , Chiral nitrogen donor ligand claim 2 , followed by recrystallization to produce the desired chemical compound.3. The isolated chemical compound of wherein the recrystallization process comprises the steps of removal of solvent and re-dissolving the product in a particular solvent system to obtain crystals. This application is a divisional (“DIV”) of U.S. Nonprovisional Patent Application No. 16/211,806 filed on Dec. 6, 2018, which is a divisional (“DIV”) of U.S. Non-Provisional patent application Ser. No. 15/469,654 filed on Mar. 27, 2017, which itself is a CIP claiming ...

GOLD(III) ANTI-CANCER AGENTS

A method for treating cancer and gold(III) complexes with diaminocyclohexane ligand as anticancer agents. Also described are a pharmaceutical composition incorporating the gold(III) complexes and a method of synthesizing the gold(III) complexes. 114-. (canceled)16. The gold(III) complex of claim 15 , wherein at least one Ris an optionally substituted C-Calkyl group.17. The gold(III) complex of claim 16 , wherein at least one Ris an optionally substituted alkyl group.18. The gold(III) complex of claim 15 , which is represented by formula (I) claim 15 , wherein X is chloride.19. The gold(III) complex of claim 15 , further comprising at least one counterion which is at least one pharmaceutically acceptable anion selected from the group consisting of fluoride claim 15 , chloride claim 15 , bromide claim 15 , iodide claim 15 , nitrate claim 15 , sulfate claim 15 , phosphate claim 15 , methanesulfonate claim 15 , ethanesulfonate claim 15 , p-toluenesulfonate claim 15 , salicylate claim 15 , malate claim 15 , maleate claim 15 , succinate claim 15 , tartrate claim 15 , citrate claim 15 , acetate claim 15 , perchlorate claim 15 , trifluoromethanesulfonate claim 15 , acetylacetonate claim 15 , hexafluorophosphate claim 15 , and hexafluoroacetylacetonate.20. The gold(III) complex of claim 19 , wherein the at least one counterion is chloride. This application claims the priority of the filing date of the U.S. Provisional Patent Application No. 62/262,550 filed Dec. 3, 2015, the disclosure of which is hereby incorporated herein by reference in its entirety.This project was funded by the National Plan for Science and Innovation (MARIFAH)-King Abdulaziz City for Science and Technology (KACST) through the Science and Technology Unit at King Fand University of Petroleum and Minerals (KFUPM) of Saudi Arabia, award No. 14-MED64-04.Technical FieldThe present disclosure relates to gold(III) complexes with anti-cancer activity and a method of treating cancer.Description of the Related ...

COMPOSITIONS AND METHODS COMPRISING CONDUCTIVE METAL ORGANIC FRAMEWORKS AND USES THEREOF

Compositions and methods comprising metal organic frameworks (MOFs) and related uses are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core. 129-. (canceled)30. A method of synthesizing a porous metal organic framework (MOF) comprising:exposing a plurality of metal ions to a plurality of precursor ligands in the presence of an oxidant and a base to form a MOF comprising a portion of the plurality of metal ions each coordinated with at least one ligand,wherein each ligand comprises at least two sets of ortho-diimine groups arranged about an organic core.311. The method of claim , wherein the base is selected from the group consisting of NHand NHOH.321. The method of claim , wherein the oxidant is selected from the group consisting of air , oxygen , ferricinium , nitrosonium , Ag , and Ag.331. The method of claim , wherein the metal ions are provided as a salt.341. The method of claim , wherein the salt is selected from the group consisting of chloride , fluoride , bromide , iodide , NO , SO , and ClO.351. The method of claim , wherein each ligand comprises at least two sets of ortho-diimine groups arranged about an organic core is formed by oxidizing a precursor ligand , wherein each precursor ligand comprises at least two sets of ortho-diamine groups arranged about the organic core.361. The method of claim , wherein the at least one precursor ligand comprises at least two sets of ortho-diamine groups arranged about an organic core.39. The method of claim 38 , wherein each Ris hydrogen.40. (canceled)411. Use of a MOF formed by the method of claim claim 38 , as a conductive material.421. A film comprising a MOF formed by the method of claim .431. Use of a MOF formed by the method of claim claim 38 , for chemical sensing.441. A chemical sensor comprising a MOF formed by the method of claim .451. An ...

TUNABLE ELECTRICAL CONDUCTIVITY IN METAL-ORGANIC FRAMEWORK THIN FILM DEVICES

A composition including a porous metal organic framework (MOF) including an open metal site and a guest species capable of charge transfer that can coordinate with the open metal site, wherein the composition is electrically conductive. A method including infiltrating a porous metal organic framework (MOF) including an open metal site with a guest species that is capable of charge transfer; and coordinating the guest species to the open metal site to form a composition including an electrical conductivity greater than an electrical conductivity of the MOF. 1. A method comprising:infiltrating a porous metal organic framework (MOF) comprising an open metal site, wherein the MOF comprises a plurality of metal ions or metal clusters and a plurality of organic ligands, with a guest species that is capable of charge transfer, wherein the guest species is located within a pore of the MOF; andcoordinating the guest species to the open metal site to form a composition comprising an electrical conductivity greater than an electrical conductivity of the MOF.2. The method of claim 1 , wherein infiltrating comprises exposing the MOF to the guest species for a period of time.3. The method of claim 2 , wherein an electrical conductivity of the composition is related to the exposure time.4. The method of claim 1 , wherein the MOF comprises copper.5. The method of claim 4 , wherein the MOF comprises Cu(BTC).6. The method of claim 4 , wherein the guest species comprises a nitrile moiety claim 4 , a thiol moiety claim 4 , or a carbonyl moiety.7. The method of claim 4 , wherein the guest species comprises 7 claim 4 ,7 claim 4 ,8 claim 4 ,8-tetracyanoquinododimethane.8. The method of claim 5 , wherein the guest species comprises 7 claim 5 ,7 claim 5 ,8 claim 5 ,8-tetracyanoquinododimethane.9. The method of claim 1 , wherein the guest species is selected from the group consisting of a nitrile moiety claim 1 , a thiol moiety claim 1 , a carbonyl moiety claim 1 , a thiolate moiety claim 1 ...

CARBON NANOTUBE COMPOSITE AND PREPARATION METHOD OF THE SAME

A carbon nanotube (CNT) composite of which one or more specific functional groups are bonded to surface of a CNT, and a method of preparing a CNT composite are provided. The method includes the steps of introducing an acylhalide group to surface of a CNT, and causing a reaction of the acylhalide group with a polysiloxane having amine groups so as to prepare a CNT composite of which the polysiloxane is bonded to the surface by the medium of an amide group. The CNT composite can fix metal particles uniformly and densely thereon, can have improved mechanical and electrical properties, and can be applied to various industrial fields. 1. A method of preparing a CNT composite , comprising the steps of:introducing an acylhalide group to surface of a CNT;causing a reaction of the acylhalide group with a polysiloxane having amine groups so as to prepare the CNT composite of which the polysiloxane is bonded to the surface of the CNT by the medium of an amide group; anda step of fixing a metal nanoparticle to the CNT composite,wherein the step of introducing the acylhalide group comprises the steps of treating the CNT with an acid and causing a reaction of the acid-treated CNT with thionyl chloride or phosphorus chloride, andthe step of fixing the metal nanoparticle to the CNT composite comprises the step of causing a reaction of the CNT composite in a precursor solution of the metal nanoparticles.3. The method according to claim 2 , wherein Rand Rin Chemical Formula 2 are independently a methyl or a phenyl.4. The method according to claim 1 , further comprising a step of dispersing the CNT composite with ultrasonic waves in the presence of an organic solvent.5. The method according to claim 1 , further comprising a step of curing the CNT composite before the step of fixing a metal nanoparticle to the CNT composite.6. The method according to claim 5 , wherein the curing step is carried out at a temperature of 260 to 300° C.7. The method according to claim 1 , wherein the ...

METHOD FOR PREPARATION OF A LEAD-FREE PRIMARY EXPLOSIVE

Described are methods for preparing copper(I) 5-nitrotetrazolate, which include reacting copper(II) sulfate pentahydrate, sodium nitrite, 5-aminotetrazole, and at least one of nitric acid and urea in water. 1. A method of preparing copper(I) 5-nitrotetrazolate comprising preparing an aqueous reaction mixture of copper(II) sulfate pentahydrate , sodium nitrite , 5-aminotetrazole , and at least one of nitric acid and urea.2. The method of claim 1 , further comprising maintaining the reaction mixture in the temperature range of about 0° C. to about 90° C. for greater than about 5 minutes.3. The method of claim 1 , further comprising adding an aqueous solution of sodium ascorbate to the reaction mixture.4. The method of claim 3 , further comprising stirring the reaction mixture for about 30 minutes at an elevated temperature.5. The method of claim 3 , wherein the aqueous solution of sodium ascorbate is added at a rate that causes copper(I) 5-nitrotetrazolate to precipitate.6. The method of claim 3 , wherein the aqueous solution of sodium ascorbate is added at a rate that forms crystalline copper(I) 5-nitrotetrazolate.7. The method of claim 6 , further comprising washing the copper(I) 5-nitrotetrazolate at least one time.8. The reaction product of:(a) a copper(II) salt;(b) sodium nitrite;(c) nitric acid;(d) 5-aminotetrazole;(e) sodium ascorbate; and(f) water.9. A method of preparing copper(I) 5-nitrotetrazolate claim 6 , comprising the steps of:(a) providing an aqueous solution of copper(II) sulfate pentahydrate and sodium nitrite;(b) adding an aqueous solution of 5-aminotetrazole, nitric acid and copper(II) sulfate pentahydrate;(c) combining said solutions to form a mixture while cooling the mixture;(d) adding additional nitric acid to the mixture; and(e) adding an aqueous solution of sodium ascorbate to the mixture.10. The method of claim 9 , further comprising(f) maintaining the mixture in the temperature range of about 0° C. to about 90° C. for greater than about 5 ...

METHOD FOR PRODUCING COMPLEX COMPOSED OF ORGANIC NITROGEN COMPOUND AND COPPER (I) SALT OF FLUOROOXO ACID

Disclosed is a method for producing a complex composed of an organic nitrogen compound and a copper (I) salt of a fluorooxo acid with high yield while reducing the corrosion of a reaction vessel. The complex can be produced with high yield while reducing the corrosion of a reaction vessel, by reacting a copper (I) salt, a fluorooxo acid salt and an organic nitrogen compound with one another. 2. The method for producing a complex according to claim 1 , wherein the copper(I) salt is copper(I) chloride and/or copper(I) bromide.3. The method for producing a complex according to claim 1 , wherein the fluorooxo acid salt is at least one kind selected from the group consisting of sodium tetrafluoroborate claim 1 , potassium tetrafluoroborate claim 1 , sodium hexafluorosilicate claim 1 , potassium hexafluorosilicate claim 1 , sodium hexafluorophosphate and potassium hexafluorophosphate.4. The method for producing a complex according to claim 1 , wherein the organic nitrogen compound is acetonitrile.5. The method for producing a complex according to claim 1 , wherein the reaction is performed at −20 to 40° C.6. The method for producing a complex according to claim 1 , wherein the fluorooxo acid salt is used in a proportion of 0.5 to 10 molar equivalent relative to the copper(I) salt.7. The method for producing a complex according to claim 1 , wherein the organic nitrogen compound is used in a proportion of 1 to 50 molar equivalent relative to the copper(I) salt.8. The method for producing a complex according to claim 1 , wherein a reaction solvent used in the reaction is water claim 1 , a polar solvent claim 1 , or a mixed solvent thereof.9. The method for producing a complex according to claim 1 , wherein the complex composed of an organic nitrogen compound and a copper(I) salt of a fluorooxo acid is represented by the following general formula (4):{'br': None, 'sub': n', 'd, '[CuL]Z \u2003\u2003(4),'}wherein, Z denotes a fluorooxo acid group, L denotes a substituted or non ...

REGENERATION METHOD FOR CU-BTC MATERIAL

A method for regenerating a Cu-BTC material includes: impregnating a Cu-BTC adsorbed with guest molecules in an acidic proton solvent or in a steam environment thereof, and filtering the Cu-BTC material, to obtain a solid; impregnating the solid in a non-acidic organic solvent or a steam environment thereof, and finally filtering, washing and drying the solid, to complete the generation of the Cu-BTC material. 1. A method for regenerating a Cu-BTC material , comprising: impregnating Cu-BTC adsorbed with guest molecules in an acidic proton solvent or a steam environment thereof , and filtering the Cu-BTC material to obtain a solid; and impregnating the solid in a non-acidic organic solvent or a steam environment thereof , and finally filtering , washing and drying the solid , to complete the regeneration of the Cu-BTC material.2. The method according to claim 1 , wherein the guest molecules are gas molecules or organic dye molecules; and are preferably one or more selected from CO claim 1 , CO claim 1 , N claim 1 , H claim 1 , CH claim 1 , CH claim 1 , CH claim 1 , NO claim 1 , NO claim 1 , SO claim 1 , HS claim 1 , methyl orange claim 1 , methyl blue claim 1 , methylene blue claim 1 , methyl red and Sudan red.3. The method according to or claim 1 , wherein the guest molecule adsorption in the Cu-BTC adsorbed with guest molecules is 0 to 100 wt % claim 1 , and further 0.1 wt % to 100 wt %.4. The method according to claim 1 , wherein the specific surface area of the Cu-BTC adsorbed with guest molecules and the Cu-BTC material is greater than 600 m/g.5. The method according to claim 1 , wherein the acidic proton solvent is at least one selected from acetic acid claim 1 , formic acid claim 1 , hydrochloric acid claim 1 , sulfuric acid claim 1 , nitric acid claim 1 , carbonic acid claim 1 , phosphoric acid claim 1 , hydrofluoric acid claim 1 , hydrogen bromide and hydrogen iodide.6. The method according to or claim 1 , wherein the acidic proton solvent has a pH value of ...

TITANIUM HETEROMETALLIC METAL-ORGANIC SOLIDS, METHOD FOR OBTAINING THEM AND THEIR USES

The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure. 1. A crystalline and porous Ti(IV) heterometallic MOF solid , characterised in that it comprises a tricarboxylic ligand L selected from a tricarboxylic C-aryl acid , a tricarboxylic CN-aryl acid or a derivative thereof of the tricarboxylic (C′-aryl)-C-aryl or (C′-aryl)-CN-aryl acid type , as the organic part of the MOF , and Tiwith at least one divalent metal Min the structural unit and inorganic part of the MOF , wherein Tiand the at least one divalent metal Mare homogeneously distributed at atomic level , and wherein the MOF solid also includes at least one polar solvent S molecule.2. The Ti(IV) heterometallic MOF solid claim 1 , according to claim 1 , wherein the polar solvent S can be selected from N claim 1 ,N′-dimethylformamide claim 1 , N claim 1 ,N′-diethylformamide claim 1 , N claim 1 ,N′-dimethylacetamide claim 1 , N-methyl-2-pyrrolidone claim 1 , methanol claim 1 , ethanol claim 1 , isopropanol claim 1 , n-propanol claim 1 , water and mixtures thereof.3. The Ti(IV) heterometallic MOF solid claim 1 , according to claim 1 , wherein the inorganic part includes a proportion of titanium less than or equal to 50% claim 1 , with divalent metal(s) making up the remaining part until 100%.4. The Ti(IV) heterometallic MOF solid claim 1 , according to claim 1 , wherein the proportion of titanium is comprised between 50% and 15% claim 1 , with divalent metal(s) making up the remaining part until 100%.5. The Ti(IV) heterometallic MOF solid claim 1 , according to claim 1 , wherein Tiand the at least one divalent ...

METHOD FOR PREPARING STABILIZED METAL ION LIGAND NANOCOMPLEX AND COMPOSITIONS THEREOF

The present disclosure provides method of making a nanoparticle complex wherein the nanoparticle complex comprises a ligand and a metal cation. The disclosure also provides nanoparticle complexes, methods of treating a disease in a patient utilizing the nanoparticle complexes, methods of identifying a disease in a patient utilizing the nanoparticle complexes, and kits involving the nanoparticle complexes. 1. A method of making a nanoparticle complex , said method comprising the steps of:providing a first composition, wherein the first composition comprises at least one ligand;{'sub': n', 'y, 'providing a second composition, wherein the second composition comprises a salt of the formula MX,'}wherein M is a metal cation and X is counterion, andwherein n is an integer from 1 to 3 and y is an integer from 1 to 5; andcombining the first composition and the second composition to obtain the nanoparticle complex, wherein the nanoparticle complex comprises the ligand and M.2. The method of claim 1 , wherein the ligand is an organic molecule is capable of forming a complex with the metal cation claim 1 , wherein the organic molecule comprises an atom or a functional group capable of donating an electron pair to the metal cation claim 1 , and wherein the atom or the functional group is selected from the group consisting of S-donor claim 1 , O-donor claim 1 , N claim 1 ,O-donor claim 1 , N-donor claim 1 , P-donor claim 1 , Lewis base claim 1 , Shiff base claim 1 , macrocycle claim 1 , and N—N dimine donor.3. The method of claim 1 , wherein the ligand is a therapeutic agent claim 1 , and wherein the therapeutic agent is diethyldithiocarbamatetrihydrate (DDC).4. The method of claim 1 , wherein the ligand is a therapeutic agent and wherein the therapeutic agent is selected from the group consisting of paclitaxel claim 1 , docetaxel claim 1 , and doxorubicin.5. The method of claim 1 , wherein the ligand is an imaging agent.6. The method of claim 1 , wherein M is selected from the ...

METHOD OF SYNTHEZING METAL-ASCORBIC ACID CRYSTALS

The invention provides metal-ascorbic acid crystals and a method for synthesizing the metal-ascorbic acid crystals. The metal in the metal-ascorbic acid crystals is one of copper (Cu), gold (Au) and silver (Ag). The method for synthesizing the metal-ascorbic acid crystals includes sonicating a solution of ascorbic acid and a solvent in dark to obtain a clear solution, wherein the solvent is one of dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). A metal salt is added to the clear solution, wherein the metal salt is one of copper (II) sulfate pentahydrate (CuSO.5HO), gold (III)-chloride (AuCl), and silver sulfate (AgSO). The clear solution is sonicated after adding the metal salt to obtain a reaction mixture. Thereafter, the reaction mixture is heated in dark. The reaction mixture is treated to facilitate solvent extraction of the metal-ascorbic acid. Finally, the metal-ascorbic acid is crystallized. 1. A method of synthesizing metal-ascorbic acid crystals , wherein the metal is one of copper (Cu) , gold (Au) and silver (Ag) , the method comprising:sonicating a solution of ascorbic acid and a solvent in the absence of light to obtain a clear solution, wherein the solvent is one of dimethylformamide (DMF) and dimethyl sulfoxide (DMSO);{'sub': 4', '2', '3, 'adding metal salt to the clear solution, wherein the metal salt is one of copper (II) sulfate pentahydrate (CuSO.5HO), gold (III)-chloride (AuCl), and silver sulfate (Ag2SO4);'}sonicating the clear solution after adding the metal salt to obtain a reaction mixture;heating the reaction mixture in the absence of light; transferring the reaction mixture to a separation funnel for solvent extraction;', 'adding dichloromethane to the separation funnel;', 'adding deionized water to the separation funnel; and', 'separating an aqueous layer and reducing a volume of the aqueous layer using a rotary evaporator pump; and, 'treating the reaction mixture to facilitate solvent extraction of the metal-ascorbic acid, wherein ...

Transmetalation Methods for the Synthesis of PET and SPECT Imaging Agents

A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging agent onto an acid stable stationary phase; replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; and eluting the imaging agent including the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The imaging agent can include a targeting agent that is directly conjugated to the imaging agent or by means of a linker. The process may also apply to other metals that are non-radioactive but used as diluent metals or other metals that are strongly bound to DOTA. 1. A process for the preparation of a radionuclide imaging agent , comprising:providing an imaging agent comprising a chelated place-holder metal;loading the imaging agent onto an acid stable stationary phase;replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; andeluting the imaging agent comprising the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography or single-photon emission computed tomography.2. The process of claim 1 , wherein the place-holder metal comprises a Group 1 or 2 metal from Row 4 claim 1 , 5 claim 1 , or 6 or a Group 3 claim 1 , 4 claim 1 , 5 claim 1 , or 6 of Row 6 of the Periodic Table of Elements.3. The process of claim 1 , wherein the replacing comprises transmetalating the chelated place-holder metal with the replacement radioactive metal.4. The process of claim 3 , wherein the transmetalating comprises a period of time of less than about 24 hours.5. The process of claim 3 ...

Modular Imaging Agents Containing Amino Acids and Peptides

Targeted molecular imaging agents (TMIAs) are derived from coupling together pre-formed amino acids with imaging agents attached to their side chains. These peptide-based imaging agents may be synthesized from a single or multiple preformed amino acids containing multi-modal, multi-chelated metal, multi-dye imaging agents, or combinations of these, on the side chains of resultant peptides. These imaging amino acids or peptides may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs. 3. The compound according to claim 2 , wherein:{'sub': 2', 'n, 'A is (CH), wherein n is 1-4;'}B is a moiety selected from H, Fmoc, Boc, or Cbz;{'sub': '2', 'C is a moiety selected from OH, NH, or an activating group;'}D is a dye, or metal-chelate complex, attached directly, or via a linker;{'sub': '1', 'Ris H; and'}{'sub': '2', 'Ris H.'}4. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is Fmoc; C is NH; D is DOTA-Gd; Ris H; and Ris H.5. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is H; C is NH claim 3 , D is DOTA-Gd; Ris H; and Ris H.6. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is Fmoc; C is OH; D is DOTA-Gd; Ris H; and Ris H.7. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is Fmoc; C is NH; D is DOTA-Eu; Ris H; and Ris H.8. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is Fmoc; C is NH; D is DOTA-Eu; Ris H; and Ris H.9. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is Fmoc; C is NH; D is DOTA-Ce; Ris H; and Ris H.10. The compound according to claim 3 , wherein A is (CH) claim 3 , wherein n is 4; B is Fmoc; C is NH; D is DOTA-Cu; Ris H; and Ris H.11. The compound according ...

METHOD FOR PREPARING CU-BTC AND NANO-CU-BTC

The methods for preparing Cu-BTC and nano-Cu-BTC are disclosed. An imporous coordination compound Cu(CHO)(HO)is impregnated an organic solvent or a steam environment thereof to obtain Cu-BTC. Cu-BTC is impregnated in an acidic protic solvent environment and filtered to obtain a solid, and the solid is impregnated in a non-acidic organic solvent or a steam environment thereof, centrifuged, washed, and dried, to obtain nano-Cu-BTC. 1. A method for preparing Cu-BTC , comprising: impregnating Cu(CHO)(HO)in an organic solvent or an organic solvent steam , reacting with stifling , washing , filtering and drying , to obtain Cu-BTC.2. The method according to claim 1 , wherein Cu(CHO)(HO)is a whisker-shaped imporous coordination compound having XRD characteristic peaks at 2θ of 9.4 claim 1 , 11.35 claim 1 , 13.95 claim 1 , 16.2 claim 1 , 16.85 claim 1 , 17 claim 1 , 18.75 claim 1 , 19.45.3. The method according to claim 1 , wherein the organic solvent comprises at least one of methanol claim 1 , ethanol claim 1 , N claim 1 , N-dimethylformamide claim 1 , dimethyl sulfoxide claim 1 , acetonitrile claim 1 , sulfolane claim 1 , acetone claim 1 , dimethylacetamide and hexamethylphosphoramide.4. The method according to claim 1 , wherein the solid-liquid ratio of Cu(CHO)(HO)to the organic solvent is 1 g/L to 100 g/L; and the duration of the reaction is 1 to 60 min.5. A method for preparing nano-Cu-BTC claim 1 , comprising: impregnating Cu-BTC in an acidic protic solvent environment and filtered to obtain a solid claim 1 , impregnating the solid in a non-acidic organic solvent or a steam environment of a non-acidic organic solvent claim 1 , centrifuged claim 1 , washed claim 1 , and dried claim 1 , to obtain nano-Cu-BTC.6. The method according to claim 5 , wherein the concentration of the acidic protic solvent is pH=1 to 3.7. The method according to claim 5 , wherein the solid-liquid ratio of Cu-BTC to the acidic protic solvent is 1 g/L to 50 g/L; Cu-BTC is impregnated in the ...

Copper Complex for Capturing Carbon Dioxide

A composition and method are disclosed for capturing CO. A pollutant/greenhouse gas can be converted into a valuable organic compound using a nontoxic reducing agent. COmay be economically captured from the atmosphere, from products of combustion, or from byproducts of various chemical processes. The method reduces COin a three-step reaction cycle, in which a binuclear metal-organic compound converts COto oxalate in a redox cycle under mild conditions. 2. The compound of claim 1 , wherein L is m-xylylenebis(pyridyltriazole).3. The compound of claim 1 , wherein said compound is selected from the group consisting of [CuL(μ-CO)]; [CuL(μ-CO)](PF); [CuL(NO)](PF); [CuL(NO)](NO); [CuL](PF); [CuLCl]Cl; [CuLCl](PF); [CuL]; and [CuL].4. The compound of claim 3 , wherein L is m-xylylenebis(pyridyltriazole).5. A method for reducing carbon dioxide to oxalate; said method comprising the sequential steps of:{'claim-ref': [{'@idref': 'CLM-00001', 'claim 1'}, {'@idref': 'CLM-00001', 'claim 1'}], '(a) reacting carbon dioxide with a reduced form of the compound of to produce oxalate complexed to an oxidized form of the compound of ;'}{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(b) reacting the oxalate complex from step (a) with a mineral acid to liberate oxalate from the oxidized form of the compound of ;'}{'claim-ref': [{'@idref': 'CLM-00001', 'claim 1'}, {'@idref': 'CLM-00001', 'claim 1'}], '(c) reducing the oxidized form of the compound of from step (b) to regenerate the reduced form of the compound of ; and'}(d) repeating each of steps (a) through (c) a plurality of times.6. A method for reducing carbon dioxide to oxalate; said method comprising the sequential steps of:{'claim-ref': [{'@idref': 'CLM-00002', 'claim 2'}, {'@idref': 'CLM-00002', 'claim 2'}], '(a) reacting carbon dioxide with a reduced form of the compound of to produce oxalate complexed to an oxidized form of the compound of ;'}{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, '(b) reacting the oxalate complex ...

METAL ORGANIC FRAMEWORK NANOSHEET AND METHOD FOR PRODUCING SAME

The present disclosure provides a method for producing a metal organic framework nanosheet, including forming a metal organic framework in a sheet form between two monolayers constituting a single bilayer membrane in a case where the bilayer membranes form a hyper-swollen lamellar phase in a solvent. The present disclosure relates to a metal organic framework nanosheet including a metal organic framework disposed, in a sheet form, between two monolayers constituting a single bilayer membrane, wherein a plurality of the bilayer membranes forms a hyper-swollen lamellar phase in a solvent. 1. A metal organic framework nanosheet comprising a metal organic framework disposed , in a sheet form , between two monolayers constituting a single bilayer membrane , whereina plurality of the bilayer membranes forms a hyper-swollen lamellar phase in a solvent.2. The metal organic framework nanosheet according to claim 1 , wherein the bilayer membranes are composed of a nonionic amphiphile.3. The metal organic framework nanosheet according to claim 2 , wherein the nonionic amphiphile is at least one selected from the group consisting of an ester type surfactant claim 2 , an ether type surfactant claim 2 , an ester ether type surfactant claim 2 , an alkanolamide type surfactant claim 2 , alkyl glycoside and a higher alcohol.4. The metal organic framework nanosheet according to claim 3 , wherein the nonionic amphiphile is the ether type surfactant claim 3 , and the ether type surfactant is at least one selected from the group consisting of polyethylene glycol monoalkyl ether and polyoxyethylene alkyl phenyl ether.6. The metal organic framework nanosheet according to claim 5 , wherein 2 Подробнее

Method for producing 2,3-bisphosphinopyrazine derivative, and method for producing phosphine transition metal complex

There is provided a method for producing a 2,3-bisphosphinopyrazine derivative, the method comprising a first step of adding a base to a liquid comprising: 2,3-dihalogenopyrazine represented by the following general formula (1); a hydrogen-phosphine borane compound represented by the following general formula (2); and a deboranating agent, and allowing the resultant to react to thereby obtain the 2,3-bisphosphinopyrazine derivative represented by the following general formula (3). According to the present invention, a method for producing the industrially advantageous 2,3-bisphosphinopyrazine derivative can be provided.

Precursors for Electron Beam-Induced Deposition of Gold and Silver

Precursors are prepared and employed in electron beam induced decomposition (EBID). The EBID precursors are complexes of the formula: X-M-Y, where M is Au or Ag; X is F, Cl, Br, I, CN, OR, OCR, or R; Y is P(OR), NR, unsubstituted or substituted pyrrole, unsubstituted or substituted pyridine, unsubstituted or substituted pyrrolidine, or unsubstituted or substituted piperidine; and where R, R, R, R, and substituents of the substituted pyrrole, pyridine, pyrrolidine, or piperidine are independently H, C-Calkyl, C-Caryl, C-Cperfluoroalkyl, C-Cpartially fluorinated alkyl, and SiRRRwhere R, R, and Rare independently H, C-Calkyl, or C-Cfluorinated alkyl. The decomposition of the EBID precursor results in the formation of one or more gold, silver, or any combination thereof features on a substrate.

MATERIAL FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME

A material for an organic electroluminescent (EL) device includes a copper(I) complex represented by the following Formula 1: 2. The material for an organic EL device as claimed in claim 1 , wherein the copper(I) complex exhibits delayed fluorescence.34-. (canceled)54. The material for an organic EL device as claimed in claim claim 1 , wherein the nitrogen-containing heterocyclic ligand is 1 claim 1 ,6-naphthyridine.6. The material for an organic EL device as claimed in claim 5 , wherein X is an anion selected from the group of a halide ion claim 5 , a nitrate ion claim 5 , and a perchlorate ion.7. The material for an organic EL device as claimed in claim 6 , wherein X is one of Cl claim 6 , Br and I.10. The organic EL device as claimed in claim 9 , wherein the copper(I) complex exhibits delayed fluorescence.1112-. (canceled)1312. The organic EL device as claimed in claim claim 9 , wherein the nitrogen-containing heterocyclic ligand is 1 claim 9 ,6-naphthyridine.14. The organic EL device as claimed in claim 13 , wherein X is an anion selected from the group of a halide ion claim 13 , a nitrate ion claim 13 , and a perchlorate ion.15. The organic EL device as claimed in claim 14 , wherein X is one of Cl claim 14 , Br and I. Japanese Patent Application No. 2014-064085, filed on Mar. 26, 2014, in the Korean Intellectual Property Office, and entitled: “Material For Organic Electroluminescent Device and Organic Electroluminescence Device Including The Same,” is incorporated by reference herein in its entirety.1. FieldEmbodiments relate to a material for an organic electroluminescent device and an organic electroluminescent device including the same.2. Description of the Related ArtAn organic electroluminescence diode, which is a self-emitting type device, is being actively developed. The organic electroluminescent device (hereinafter referred to as an organic EL device) embodies light emission of a luminescent material including an organic compound of an emission layer ...

METHOD FOR PREPARING COPPER ORGANIC METAL AND COPPER PASTE

The copper organic metal is constituted to combine a copper atom, [R—CO] and amine based ligand (L), thereby making it possible to be subjected to a low temperature sintering process and having an improved conductivity at the time of forming a conductive pattern. 1. A method for preparing a copper organic metal having an amine based ligand comprising:preparing a first solution by dissolving alkanoic acid or fatty acid in an aqueous sodium hydroxide solution or an aqueous potassium hydroxide solution;mixing the first solution and a second solution having a dissolved copper salt therein; andseparating and purifying a copper organic metal from the mixed solution including the first solution and the second solution.2. A method for preparing a copper organic metal having an amine based ligand comprising:preparing a first solution by dissolving alkanoic acid or fatty acid in an aqueous sodium hydroxide solution or an aqueous potassium hydroxide solution;mixing the first solution and a second solution having a dissolved copper salt therein;separating and purifying a copper organic metal from the mixed solution including the first solution and the second solution; andreacting the separated and purified copper organic metal with amine based solvent.3. The method according to claim 2 , wherein the amine based ligand includes alkylamine.4. The method according to claim 3 , wherein the alkylamine is any one material selected from R—NH claim 3 , R—NH—R′ and R—N.5. The method according to claim 2 , wherein the amine based ligand includes a hydroxyl (—OH) group.6. The method according to claim 2 , wherein the amine based ligand includes HO—R—NH.7. A copper paste comprising:a copper powder; and{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'a copper organic metal prepared by the method for preparing a copper organic metal according to .'} This application is a divisional of U.S. application Ser. No. 13/723,908 filed on Dec. 21, 2012, which claims the benefit under 35 U.S.C. ...

CHIRAL BINUCLEAR METAL COMPLEXES FOR STEREOSELECTIVE GLYCOSIDE HYDROLYSIS OF SACCHARIDES

Disclosed herein is a class of chiral binuclear metal complexes for stereoselective glycoside hydrolysis of saccharides, and more particular chiral binuclear transition metal complex catalysts that discriminate epimeric glycosides and α- and β-glycosidic bonds of saccharides in aqueous solutions at near physiological pHs. The chiral binuclear metal complexes include a Schiff-base-type ligand derived from a chiral diamino building block, and a binuclear transition metal core, each which can be varied for selectivity. The metal core is a Lewis-acidic metal ion, such as copper, zinc, lanthanum, iron and nickel. The Schiff-base may be a reduced or non-reduced Schiff-base derived from aliphatic linear, aliphatic cyclic diamino alcohols or aromatic aldehydes. The ligand can be a penta- or heptadentate ligand derived from pyridinecarbaldehydes, benzaldehydes, linear or cyclic diamines or diamino alcohols. 1. A chiral binuclear transition metal complex for stereoselective glycoside hydrolysis of saccharides , said chiral binuclear transition metal complex comprising:a Schiff-base ligand derived from chiral diamino building blocks; anda binuclear transition metal core.2. The chiral binuclear transition metal complex of wherein said chiral diamino building block is varied by changing the distance of the metals of said binuclear core in order to tune the complexes selectivity.3. The chiral binuclear transition metal complex of wherein said Schiff-base is a reduced or non-reduced Schiff-base derived from aliphatic linear claim 1 , aliphatic cyclic diamino alcohols or aromatic aldehydes.4. The chiral binuclear transition metal complex of wherein said ligand is a penta- or heptadentate ligand derived from pyridinecarbaldehydes claim 1 , benzaldehydes claim 1 , linear or cyclic diamines or diamino alcohols.6. The chiral binuclear transition metal complex of wherein said metal core is a Lewis-acidic metal ion selected from the group consisting of copper claim 1 , zinc claim 1 , ...

POROUS POLYMER METAL COMPLEX, GAS ADSORBENT, AND GAS SEPARATION DEVICE AND GAS STORAGE DEVICE USING SAME

An object of the present invention is to provide a porous polymer metal complex which can be used as a gas adsorbent and contains two or more types of similar ligands. A porous polymer metal complex is provided expressed by [CuX](1) (in the Formula, X represents two or more types of isophthalic acid ions selected from the group consisting of isophthalic acid ions and isophthalic acid ions having a substituent at position 5, at least an amount of one type of X is 5 mol % to 95 mol % of the total number of moles of X, and n represents an assembly number of constituent units expressed by CuX and is not particularly limited). 1. A porous polymer metal complex expressed by Formula (1):{'br': None, 'sub': 'n', '[CuX]\u2003\u2003(1)'}(in the Formula, X represents two or more types of isophthalic acid ions selected from the group consisting of isophthalic acid ions and isophthalic acid ions having a substituent at position 5, at least an amount of one type of X is 5 mol % to 95 mol % of the total number of moles of X, and n represents an assembly number of constituent units expressed by CuX and is not particularly limited).2. The porous polymer metal complex according to claim 1 , expressed by Formula (2):{'br': None, 'sub': 1-m', 'm', 'n, '[CuXY]\u2003\u2003(2)'}{'sub': 1-m', 'm, '(in the Formula, each of X and Y represents isophthalic acid ions or isophthalic acid ions having a substituent at position 5, X and Y are different from each other, 0.05≦m≦0.95 is satisfied, and n represents an assembly number of constituent units expressed by CuXYand is not particularly limited).'}3. The porous polymer metal complex according to claim 1 ,wherein the porous polymer metal complex has a paddle-wheel structure having vertically coordinated two units in which a copper ion is coordinated to four carboxyl groups,the paddle-wheel structure is connected by isophthalic acid derivatives to form a Kagome structure constituted by six-membered rings and three-membered rings, andthe Kagome ...

METAL COORDINATION COMPLEX FOR DETECTION OF VAPORS AND ANIONS AND PROCESS FOR THE PREPARATION THEREOF

The present invention discloses novel multi-action copper complexes which are used for reversible vapochromic detection of polar solvents as well as anion sensing in both aqueous and non-aqueous media. 3. The complex as claimed in claim 1 , wherein said complex shows vapochromic behavior for polar solvent within a minute.4. The complex as claimed in claim 3 , wherein the polar solvent is selected from the group consisting of methanol claim 3 , ethanol claim 3 , acetone claim 3 , dimethylformamide claim 3 , dimethyl sulfoxide and Tetrahydrofuran.5. The complex as claimed in claim 1 , wherein said complex showed colour change in the solid state.6. A process for the synthesis of complex of formula X as claimed in and the said process comprising the steps of:{'sub': '3', 'a. adding triethylamine (EtN) to a stirred solution of isonicotinoylchloride in dichloromethane (DCM) followed by adding 2-phenethylamine with stirring for period in the range of 7 to 8 hrs at room temperature in the range of 20 to 30° C. to obtain N-phenethylisonicotinamide ligand;'}{'sub': 3', '2', '2, 'b. adding methanolic solution of N-phenethylisonicotinamide ligand of step (a) to Cu(NO). 3HO with stirring followed by refluxing, filtering and separating the solution in two parts;'}c. crystallizing one part of the solution as obtained in step (b) in methanol to yield blue coloured needle shaped crystals of complex of formula (1) and crystallizing the second part of the solution as obtained in step (b) in a MeOH-water mixture to obtain green coloured plates of complex of formula (2);d. adding water to the blue crystals of formula 1 to obtain green crystal of formula 2 and suspending green crystals of formula 2 in methanol to yield blue crystals of formula 1.7. A process for selective claim 1 , naked eye detection of anions in aqueous and non-aqueous medium using complex of formula X comprising the steps of:i. suspending the powder of complex of formula X in aqueous solution of tetrabutylammonium ( ...

TWO-DIMENSIONAL METAL-ORGANIC-FRAMEWORKS

Synthesizing a metal-organic-framework includes combining a first solution and a second solution to yield a synthetic medium. The first solution typically includes a solvent, an inhibitor, a metal capping agent, a ligand, and a metal source, and the second solution typically includes a deprotonating agent and a buffer. The metal and the ligand are reacted in the synthetic medium to yield a two-dimensional metal-organic-framework in the form of a nanosheet, and the two-dimensional metal-organic-framework is removed from the synthetic medium. The two-dimensional metal-organic framework has an aspect ratio of at least 300 or at least 1000. 1. A method of synthesizing a metal-organic-framework , the method comprising: the first solution comprises a solvent, an inhibitor, a metal capping agent, a ligand, and a metal source comprising a metal, and', 'the second solution comprises a deprotonating agent and a buffer;, 'combining a first solution and a second solution to yield a synthetic medium, whereinreacting the metal and the ligand in the synthetic medium to yield a two-dimensional metal-organic-framework in the form of a nanosheet; andremoving the two-dimensional metal-organic-framework from the synthetic medium.2. The method of claim 1 , wherein the solvent comprises N claim 1 ,N-diethylformamide.3. The method of claim 1 , wherein the solvent is free of added water.4. The method of claim 1 , wherein the solvent is free of added N claim 1 ,N-dimethylformamide.5. The method of claim 1 , wherein the inhibitor comprises formic acid.6. The method of claim 1 , wherein the metal capping agent comprises pyridine.7. The method of claim 1 , wherein the ligand comprises terephthalic acid.8. The method of claim 1 , wherein the metal source comprises zinc nitrate claim 1 , copper nitrate claim 1 , or both.9. The method of claim 1 , wherein the metal source is free of acetate.10. The method of claim 1 , wherein the deprotonating agent comprises triethylamine.11. The method of claim ...

ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

An organometallic compound represented by Formula 1 or 2 and an organic light-emitting device including the same. 2. The organic light-emitting device of claim 1 , whereinthe emission layer comprises the organometallic compound.3. The organic light-emitting device of claim 1 , whereinthe emission layer consists of the organometallic compound; orthe emission layer comprises the organometallic compound and a host, and an amount of the organometallic compound in the emission layer is in a range of about 0.01 parts by weight to about 50 parts by weight based on 100 parts by weight of the emission layer.4. The organic light-emitting device of claim 3 , whereinthe host comprises two different hosts.5. The organic light-emitting device of claim 1 , whereinthe emission layer comprises the organometallic compound, andthe emission layer emits blue light having a maximum emission wavelength of about 430 nm to about 490 nm.6. The organic light-emitting device of claim 1 , whereinthe first electrode is an anode,the second electrode is a cathode,the organic layer further comprises a hole transport region between the first electrode and the emission layer and an electron transport region between the emission layer and the second electrode,the hole transport region comprises at least one selected from a hole injection layer, a hole transport layer, a buffer layer, an emission auxiliary layer, and an electron blocking layer, andthe electron transport region comprises at least one selected from a hole blocking layer, an electron transport layer, and an electron injection layer.7. The organic light-emitting device of claim 6 , whereinthe electron transport region comprises a hole blocking layer, andthe hole blocking layer comprises a phosphine oxide-containing compound or a silyl-containing compound.9. The organometallic compound of claim 8 , wherein{'sub': '11', 'Mis selected from Pt, Pd, Cu, Ag, and Au.'}10. The organometallic compound of claim 8 , wherein{'sub': 11', '13, 'Ato Aare ...

HOLE TRANSPORTING MATERIAL FOR AUTOMOTIVE PEROVSKITE SOLAR CELL HAVING HIGH HEAT RESISTANCE, PEROVSKITE SOLAR CELL INCLUDING THE SAME, AND METHOD FOR MANUFACTURING THE SAME

A hole transporting material having excellent heat resistance and durability, a perovskite solar cell including the hole transporting material in a hole transporting layer, and a method for manufacturing the solar cell are provided. Provided is a perovskite solar cell having PCE which is equal to or greater than PCE in the related art because the hole transporting layer is formed by using the hole transporting material in which the phthalocyanine-based organic ligand is coordinate-bonded to metal. Also, provided is a perovskite solar cell which can maintain initial PCE for a long time in a wide temperature range when the hole transporting material is used as the hole transporting layer due to excellent heat resistance and durability. 1. A hole transporting material for an automotive perovskite solar cell with high heat resistance in which a phthalocyanine-based organic ligand is coordinate-bonded to a metal.2. The hole transporting material of claim 1 , wherein the metal is copper (Cu) claim 1 , zinc (Zn) or cobalt (Co).3. The hole transporting material of claim 1 , wherein the phthalocyanine-based organic ligand includes a tert-butyl substituent.5. An automotive perovskite solar cell including a hole transporting layer constituted by the hole transporting material of .6. The automotive perovskite solar cell of claim 5 , comprising:a first electrode;an electron transporting layer formed on the first electrode;a light absorbing layer formed on the electron transporting layer and including a compound having a perovskite structure;a hole transporting layer formed on the light absorbing layer; anda second electrode formed on the hole transporting layer.7. A method for manufacturing an automotive perovskite solar cell claim 5 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'forming a hole transporting layer by solution-casting the hole transporting material of .'}8. The method of claim 7 , wherein the solution-casting is performed by any one process ...

COMPOSITION OF MATTER

The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding allylic substrates and substituted hydroxylamines, in the presence of a catalyst, said catalyst comprising copper compounds and a chiral ligand. Examples of chiral amine compounds which can be made using the method include Vigabatrin, Ezetimibe Terbinafine, Naftifine 3-methylmorphine, Sertraline, Cinacalcet, Mefloquine hydrochloride, and Rivastigmine. There are over 20,000 known bioactive molecules with chiral N-substituted allylic amine substructure. The method may also be used to produce non-natural chiral β-aminoacid esters, a sub-class of chiral N-substituted allylic amine compounds. Examples of β-aminoacid ester which can be produced by the disclosed method, include, but are not limited to, N-(2-methylpent-1-en-3-yl)benzenamine and Ethyl 2-methylene-3-(phenylamino)butanoate. Further, the products of the method described herein can be used to produce chiral heterocycles and bioactive molecules or materials. A novel chiral copper-BINAM nitrosoarene complex is also set forth. 1. A chemical compound having the formula [Cu(BINAM)(ArNO)]OTf.2. The chemical compound of wherein the compound is a chiral copper-BINAM nitrosoarene complex.3. A chemical compound comprising:a. a copper atom;b. two nitrosoarenes;c. two BINAM ligands;d. two triflates.4. The chemical compound of wherein the compound is a chiral copper-BINAM-nitrosoarene complex.5. The chemical compound of wherein the copper-nitroso complex is chiral.6. The chemical compound of wherein at least one ligand is chiral.7. The chemical compound synthesized from the process of combining copper triflate (Cu(OTf)) claim 3 , and R(+)-BINAM in the presence of toluene.8. The chemical compound of wherein the process comprises the steps of first creating a mixture of Cu(OTf) claim 7 , R(+)-BINAM claim 7 , and toluene claim 7 , stirring the mixture claim 7 , and removing ...

Method for Producing an Organic Electronic Component, and Organic Electronic Component

A method for producing an organic electronic component and an organic electronic component are disclosed. In an embodiment the component comprises at least one organic electronic layer having a matrix, wherein the matrix contains a metal complex as a dopant, wherein the metal complex comprises at least one metal atom M and at least one ligand L bonded to the metal atom M. 115-. (canceled)17. The method according claim 16 , wherein the source is a linear source.18. The method according to claim 16 , wherein the metal atom M of the metal complex is selected from the group consisting of main group metals of groups 13 to 15 of the periodic table of elements and metals Cu claim 16 , Cr claim 16 , Mo claim 16 , Rh and Ru.19. The method according to claim 16 , wherein the metal atom M of the metal complex is Bi or Cu.20. The method according to claim 16 , wherein at least one of the substituents Ris a —CFgroup.21. The method according to claim 16 , wherein ligand L comprises precisely two substituents R claim 16 , each forming a —CFgroup.22. The method according to claim 16 , wherein ligand L comprises precisely two substituents R claim 16 , each forming a —CFgroup and each being arranged in 3 claim 16 ,5-position on the benzene ring of ligand L.23. The method according to claim 16 , wherein the substituents Rare mutually independently selected from the group consisting of methyl claim 16 , ethyl claim 16 , n-propyl claim 16 , iso-propyl claim 16 , n-butyl claim 16 , iso-butyl claim 16 , tert-butyl and substituted and unsubstituted phenyl.24. The method according to claim 16 , wherein both Eand Eare oxygen.27. The method according to claim 16 , wherein the metal complex has a decomposition temperature which is greater than 10 Kelvin above a sublimation temperature of the metal complex.28. The method according to claim 16 , wherein the metal complex has a decomposition temperature which is greater than 40 Kelvin above a sublimation temperature of the metal complex.29. The ...

METHODS FOR PREPARING METAL CARBOXYLATES IN ONE-POT REACTION

The present invention relates to methods of manufacturing multiple metal propionates in a single reaction using sodium hydroxide as initiator and propionic acid as solvent. The method provides up to 95% conversion with greater than 60% yield. In addition, the method significantly reduces the cost or production by shortening reaction time, eliminating secondary mixing process, and providing simultaneous drying and micronization steps. 1. A method of manufacturing one or more metal carboxylates in a single unit reaction in free-flowing micronized form.2. The method of comprising the steps of: mixing one or more metal salts with one or more C2 to C4 carboxylic acids in the presence of an alkali hydroxide to form one or more metal carboxylates in both mono-nuclear and di-nuclear carboxylates.3. The method of wherein the metal salt comprises a metal selected from the group consisting of zinc claim 2 , copper claim 2 , manganese claim 2 , and cobalt.4. The method of wherein the salt is selected from the group consisting of sulfate chloride claim 2 , carbonate and oxide.5. The method according to claim 1 , wherein sequence of operations such as reaction claim 1 , drying and micronization are carried out using a single equipment called turbo reactor.6. The method of wherein the product containing one or more metal carboxylates comprise less than 0.2% by weight moisture and have a particle size of less than about 500 microns.78. The method of wherein the reaction occurs at a temperature of at least 70° C.87. The method of claim wherein the temperature is 92±5° C.9. The method of wherein the processing time is about three to four hours.10. The method of further including the step of removing solvent from the metal propionates.11. The method of further comprising the steps of drying and cooling the product.12312. The method of claim further including the step of agitating the product.13. The method of wherein at least two metal salts are mixed with propionic acid.14. The ...

COVALENT ORGANIC FRAMEWORKS WITH A WOVEN STRUCTURE

The disclosure provides for covalent organic frameworks (COFs) that constructed from weaving a plurality of long organic threads together. In particular, the disclosure provides for the construction of woven COFS, where long organic strands are connected together in a woven pattern using organic ligands/complexes that when orientated in certain geometries are capable of reversibly binding metal ions. 1. A woven covalent organic framework that comprises a plurality of long organic threads that are mutually interlaced at regular intervals so as to form points-of-registry ,wherein the long organic threads comprise organic linking ligands that have been covalently bound together and wherein at least some portion of the organic linking ligands further comprise heteroatoms and/or functional groups capable of coordinating a metal, metal ion or metal containing complex, andwherein the points-of-registry may be metalated to comprise coordinated metals, metal ions, or metal containing complexes, or the points-of-registry may be de-metalated.3. The woven covalent organic framework of claim 2 , wherein M is a metal or a metal ion selected from the group consisting of Li claim 2 , Na claim 2 , K claim 2 , Rb claim 2 , Cs claim 2 , Be claim 2 , Mg claim 2 , Ca claim 2 , Sr claim 2 , Ba claim 2 , Sc claim 2 , Sc claim 2 , Sc claim 2 , Y claim 2 , Y claim 2 , Y claim 2 , Ti claim 2 , Ti claim 2 , Ti claim 2 , Zr claim 2 , Zr claim 2 , Zr claim 2 , Hf claim 2 , Hf claim 2 , V claim 2 , V claim 2 , V claim 2 , V claim 2 , Nb claim 2 , Nb claim 2 , Nb claim 2 , Nb claim 2 , Ta claim 2 , Ta claim 2 , Ta claim 2 , Ta claim 2 , Cr claim 2 , Cr claim 2 , Cr claim 2 , Cr claim 2 , Cr claim 2 , Cr claim 2 , Cr claim 2 , Mo claim 2 , Mo claim 2 , Mo claim 2 , Mo claim 2 , Mo claim 2 , Mo claim 2 , Mo claim 2 , W claim 2 , W claim 2 , W claim 2 , W claim 2 , W claim 2 , W claim 2 , W claim 2 , Mn claim 2 , Mn claim 2 , Mn claim 2 , Mn claim 2 , Mn claim 2 , Mn claim 2 , Mn claim 2 , Re claim ...

Method for Producing an Organic Electronic Component, and Organic Electronic Component

A metal complex is disclosed. In an embodiment the metal complex includes at least one metal atom M and at least one ligand L attached to the metal atom M, wherein the ligand L has the following structure: 2. The metal complex according to claim 1 , wherein the metal M is a main group metal.3. The metal complex according to claim 1 , wherein the metal M is a main group metal of groups 13 to 15 of the periodic table of elements.4. The metal complex according to claim 1 , wherein the metal M is Bi.5. The metal complex according to claim 1 , wherein the metal M is Bi in an oxidation state III.6. The metal complex according to claim 1 , wherein the substituent Ris an at least difluorinated substituent.7. The metal complex according to claim 1 , wherein the substituent Ris a perfluorinated substituent.8. The metal complex according to claim 1 , wherein the substituent Ris a —CFgroup.9. The metal complex according to claim 1 , wherein the substituent Ris a —CFgroup and the metal M is Bi.16. The metal complex according to claim 1 , wherein m=0. This is a continuation application of U.S. application Ser. No. 15/515,735, entitled “Method for Producing an Organic Electronic Component, and Organic Electronic Component” which was filed on Mar. 30, 2017 which is a national phase filing under section 371 of PCT/EP2014/079049, filed Dec. 22, 2014, which claims the priority of German patent application 10 2014 114 231.4, filed Sep. 30, 2014, all of which are incorporated herein by reference in its entirety.The invention relates to a method for producing an organic electronic component wherein the organic electronic layer is obtained by means of gas-phase deposition. The invention further relates to an organic electronic component.Organic electronics is concerned with applications of organic matrix materials for converting light into electrical current and vice versa and with the construction of electrical components using organic semiconductor material. Examples of the former ...

BINUCLEAR METAL(I) COMPLEXES FOR OPTOELECTRONIC APPLICATIONS

Metal(I) complexes of the MX(E∩D)form, having a structure of formula A 123-. (canceled)28. The metal(I) complex of claim 27 , wherein A claim 27 , Q claim 27 , G and Y are each bound to each other claim 27 , and thereby forming one of an imidazolidine and an imidazole derivative claim 27 , leading with the unit Z to form annulated ring systems claim 27 , and forming annulated ring systems with the groups R-R.29. The metal(I) complex of claim 24 , wherein E∩D comprises at least one substituent for increasing the solubility of the metal(I) complex in an organic solvent claim 24 , the substituent is selected from the group consisting of:branched, unbranched or cyclic alkyl chains comprising a length of C1 to C30,branched, unbranched or cyclic alkoxy chains comprising a length of C1 to C30,branched, unbranched or cyclic perfluoroalkyl chains comprising a length of C1 to C30, andpolyethers comprising a chain length of 3-50 repeat units.30. The metal(I) complex of claim 24 , wherein E∩D comprises at least one substituent selected from the group consisting of electron conductors and hole conductors for increasing charge carrier transport.32. The method of claim 31 , wherein the reaction is performed in one of dichloromethane claim 31 , acetonitrile claim 31 , tetrahydrofuran dimethyl sulfoxide claim 31 , and ethanol.33. The method of claim 32 , further comprising adding one of diethyl ether claim 32 , pentane claim 32 , hexane claim 32 , methyl-tert-butyl ether claim 32 , methanol claim 32 , ethanol and water to obtain the metal(I) complex in the form of a solid.34. The method of claim 33 , further comprising substituting at least one bidentate ligand E∩D with at least one substituent for increasing the solubility claim 33 , selected from the group consisting of:branched, unbranched or cyclic alkyl chains comprising a length of C1 to C30,branched, unbranched or cyclic alkoxy chains comprising a length of C1 to C30,branched, unbranched or cyclic perfluoroalkyl chains ...

PRODUCTION OF METAL-ORGANIC FRAMEWORKS

An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop. 1. An apparatus for producing metal organic frameworks which comprise a plurality of metal clusters , each metal cluster including one or more metal ions; and a plurality of charged multidentate linking ligands connecting adjacent metal clusters , the apparatus comprising:a tubular flow reactor which comprises a heated tubular body having an inlet into which, in use, precursor solutions are fed and flow, said precursor solutions comprising precursor compounds which form the metal organic framework, said tubular body including at least one annular loop comprising a coil;a flow restriction device comprising a back-pressure controller downstream of the tubular reactor for controlling the pressure within the tubular reactor; andan inline mixer located at or proximate the inlet to the heated tubular body, the inline mixer mixing the precursor solutions through inline mixing in a feed conduit fluidly connected to the inlet of the tubular body,wherein the precursor compounds are provided as at least two different precursor solutions fed into the same inlet of the tubular reactor at room temperature, the at least two different precursor solutions comprising a first precursor solution comprising at least one of the multidentate linking ligand; and a second precursor solution comprising the metal cluster or a metallic salt thereof,and wherein the at least two different precursor solutions are mixed at or proximate that inlet of the tubular reactor and heated during flow through the said tubular body, said flow through said tubular body mixing the precursor compounds therein to produce the metal organic frameworks.2. An apparatus according to claim 1 , wherein the average radius of each annular loop is between 10 ...

Production of metal-organic frameworks

An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop. 1. An apparatus for producing metal organic frameworks , comprising:a tubular flow reactor comprising a heated tubular body into which, in use, precursor compounds which form the metal organic framework are fed and flow, said tubular body including at least one annular loop comprising a coil;a flow restriction device comprising a back-pressure controller downstream of the tubular reactor for controlling the pressure within the tubular reactor; and a housing having a reservoir capable of receiving a MOF containing solution; and', 'a high frequency ultrasound transducer operatively connected to the reservoir and capable of applying megasonic frequencies of at least 400 kHz to the MOF containing solution,, 'an apparatus for separating a metal organic framework (MOF) from a solution, comprisingwherein the precursor compounds are provided as at least one precursor solution fed into an inlet of the tubular reactor and heated during flow through the tubular body.2. An apparatus according to claim 1 , wherein the average radius of each annular loop is between 10 and 1000 mm.3. (canceled)4. (canceled)5. An apparatus according to claim 1 , wherein the at least one annular loop form a substantially tubular shaped coil radially centered about a central axis of said coil.6. An apparatus according to claim 1 , wherein the length of the coil is greater than 50 mm.7. (canceled)8. An apparatus according to claim 1 , wherein the internal diameter of the tubular body is between 0.5 mm and 50 mm.9. (canceled)10. (canceled)11. (canceled)12. An apparatus according to claim 1 , wherein the tubular body is in located inside a heated housing.13. An apparatus according to claim 12 , wherein the tubular body heats the precursor ...

GOLD NANOPARTICLES AND METHODS OF MAKING AND USING GOLD NANOPARTICLES

Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications. 1. A method for making a gold nanoparticle , comprising:adding a reducing composition comprising a reducing agent into a flow reactor;adding a pre-determined amount of a ligand precursor composition comprising at least one ligand precursor having a thiosulfate terminal functional group, a polar linker, and a reactive moiety selected from polar functional group, a clickable functional group, a detectable label, or an enzyme-reactive moiety into the flow reactor;adding a gold nanoparticle precursor composition comprising a gold nanoparticle precursor into the flow reactor; andisolating a functionalized gold nanoparticle coupled to at least one ligand precursor of the ligand precursor composition.2. The method of claim 1 , wherein the method further comprises adding a base to the reducing composition claim 1 , the gold nanoparticle precursor composition claim 1 , or a combination thereof so as to change the speciation of the gold nanoparticle precursor claim 1 , change the pH of the reducing composition claim 1 , or a combination thereof.3. The method of claim 2 , wherein the base is selected from NaOH claim 2 , LiOH claim 2 , KOH claim 2 , and combinations thereof.4. The method of claim 1 , wherein the reducing composition is added to the flow reactor at a flow rate that results in turbulent mixing claim 1 , chaotic flow claim 1 , transition flow claim 1 , or combinations thereof of ...

CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS

The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to a biological entity are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention. 4. A compound according to wherein L is a linking moiety having from 1 to 20 atoms in the normal chain.5. A compound according to wherein L is a group of the formula{'br': None, 'sub': 2', 'a, '—(CH)—,'}{'sub': 2', '1', '12', '3', '12', '6', '18', '1', '18, 'sup': 4', '4, 'wherein optionally one or more of the CHgroups may be independently replaced by a heteroatomic group selected from S, O, P and NRwhere Ris selected from the group consisting of H, optionally substituted C-Calkyl, optionally substituted C-Ccycloalkyl, optionally substituted C-Caryl, and optionally substituted C-Cheteroaryl;'}a is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.6. A compound according to wherein a is an integer selected from the group consisting of 1 claim 5 , 2 claim 5 , 3 claim 5 , 4 claim 5 , and 5.7. A compound according to wherein L is selected from the group consisting of —CH— claim 1 , —CHCH— claim 1 , —CHCHCH— claim 1 , —CHCHCHCH— and —CHOCH—.8. A compound according to wherein L is —CHCHCH—9. A compound according to wherein Lis a linking moiety having from 1 to atoms in the normal chain.10. A compound according to wherein Lis a group of the formula{'br': None, 'sub': 2', 'a, '—(CH)—,'}{'sub': 2', '1', '12', '3', '12', '6', '18', '1', '18, 'sup': 4', '4, 'wherein optionally one or more of the CHgroups may be independently replaced by a heteroatomic group selected from S, O, P and NRwhere Ris ...

METAL-ORGANIC FRAMEWORKS FOR SELECTIVE SEPARATIONS

Disclosed herein are metal-organic frameworks (MOF) and uses thereof, including those comprising a repeat unit of the formula [Cu3(L1)2(H20)3] or [Cu3(L2)2(H20)3], wherein L1 is a ligand of the formula: (structurally represented), and where L2 is a ligand of the formula: (structurally represented). These are useful for many applications, including in the purification of hydrogen gas from production byproducts CH4 and C02, sensing, heterogeneous catalysis, drug delivery, lithium sulfide battery, membrane and analytical devices. 2. The MOF of claim 1 , wherein the repeat unit is of the formula [Cu(L1)(HO)].3. The MOF of claim 2 , wherein the MOF is activated for sorption of gas molecules.4. The MOF of claim 1 , wherein the repeat unit is of the formula [Cu(L2)(HO)].5. The MOF of claim 4 , wherein the MOF is activated for sorption of gas molecules.65. The MOF according to any one of - claims 1 , further comprising one or more than one type of guest molecule.7. The MOF of claim 6 , wherein one type of guest molecule is a solvent molecule.8. The MOF of claim 7 , wherein the solvent molecule is water.9. The MOF of claim 7 , wherein the solvent molecule is N claim 7 ,N′-dimethylformamide.10. The MOF of claim 1 , further comprising about two N claim 1 ,N′-dimethylformamide and five and half water molecules per repeat unit.11. The MOF of claim 1 , further comprising about five N claim 1 ,N′-dimethylformamide and six and half water molecules per repeat unit.12. The MOF of claim 1 , wherein the solvent molecules occupy the pores of the MOF.13. The MOF of claim 6 , wherein one type of guest molecule is a gas molecule.14. The MOF of claim 13 , wherein the gas molecule is H claim 13 , CO claim 13 , or CH.15. The MOF of claim 14 , wherein the gas molecule is CO.16. The MOF of ; wherein the gas molecule is CH.17. The MOF of ; wherein the gas molecule is H.18. The MOF of claim 14 , wherein the gas molecule is COand CH.19. The MOF of claim 1 , wherein the MOF is substantially free ...

COMPOSITIONS AND METHODS FOR CARBON DIOXIDE SENSING

Methods of sensing carbon dioxide, sensors, and related articles and systems are generally described. 1. A method of sensing carbon dioxide , comprising: the composition comprises a molecular structure comprising an electrically conductive backbone, a plurality of heteroatoms, and a plurality of pores,', 'the composition has a monolayer amount of water of greater than or equal to 2 wt %,', 'the gas or liquid comprises carbon dioxide, and', 'the gas has a relative humidity of greater than 0% RH or the liquid has a relative humidity of greater than 0% ERH., 'exposing a composition to a gas or liquid, wherein23-. (canceled)4. A sensor , comprising:a composition, the composition comprises a molecular structure comprising an electrically conductive backbone, a plurality of heteroatoms, and a plurality of pores,', 'the composition has a monolayer amount of water of greater than or equal to 2 wt %, and', 'the composition is configured to exhibit a change in electrical resistivity upon exposure to a gas comprising carbon dioxide and having a relative humidity of greater than 0% RH or upon exposure to a liquid comprising carbon dioxide and having an equilibrium relative humidity of greater than 0% ERH., 'wherein5. (canceled)6. A sensor , comprising:a metal-organic framework, the metal-organic framework is configured to exhibit a change in electrical resistivity upon exposure to a gas comprising carbon dioxide and having a humidity of greater than 0% RH or upon exposure to a liquid comprising carbon dioxide and having an equilibrium relative humidity of greater than 0% ERH, and', 'the change in electrical resistivity is directly proportional to an amount of carbon dioxide in the gas when the relative humidity of the gas is from 20% RH to 80% RH or the change in electrical resistivity is directly proportional to an amount of carbon dioxide in the liquid when the equilibrium relative humidity of the liquid is from 20% ERH to 80% ERH., 'wherein7. A sensor as in claim 4 , wherein ...

METHOD FOR PRODUCING METAL COMPLEX

Disclosed is a method for producing a metal complex comprising a multivalent carboxylic acid compound, at least one metal ion, an organic ligand capable of multidentate binding to the metal ion, and a monocarboxylic acid compound, wherein the metal ion is used in the form of a metal salt having a counter anion of the metal ion, a conjugate acid of the counter anion having a first dissociation exponent larger by 0 to 6 than that of the multivalent carboxylic acid compound, and at least one of the multivalent carboxylic acid compound, the metal ion, the organic ligand capable of multidentate binding, and the monocarboxylic acid compound is reacted in a suspended state. This method can effectively produce a metal complex. 1. A method for producing a metal complex comprising a multivalent carboxylic acid compound , at least one metal ion of a metal belonging to Groups 2 to 13 of the periodic table , an organic ligand capable of multidentate binding to the metal ion , and a monocarboxylic acid compound ,the method comprising reacting the multivalent carboxylic acid compound, the at least one metal ion, the organic ligand, and the monocarboxylic acid compound in a single stage or multiple stages, to form the metal complex,wherein:in the reacting, the metal ion is in the form of a metal salt having a counter anion of the metal ion, a conjugate acid of the counter anion having a first dissociation exponent larger by 0 to 6 than that of the multivalent carboxylic acid compound, and the monocarboxylic acid compound is the counter anion of the metal ion; andat least two of the multivalent carboxylic acid compound, the metal ion, the organic ligand, and the monocarboxylic acid compound are reacted in a suspended state so that a concentration of each of the at least two of the components in the reaction system after addition is equal to or greater than its saturated solubility.2. The method of claim 1 , wherein the reacting occurs in a solvent.3. The method of claim 1 , wherein ...

COMPOSITION OF MATTER

The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding allylic substrates and substituted hydroxylamines, in the presence of a catalyst, said catalyst comprising copper compounds and a chiral ligand. Examples of chiral amine compounds which can be made using the method include Vigabatrin, Ezetimibe Terbinafine, Naftifine 3-methylmorphine, Sertraline, Cinacalcet, Mefloquine hydrochloride, and Rivastigmine. There are over 20,000 known bioactive molecules with chiral N-substituted allylic amine substructure. The method may also be used to produce non-natural chiral β-aminoacid esters, a sub-class of chiral N-substituted allylic amine compounds. Examples of β-aminoacid ester which can be produced by the disclosed method, include, but are not limited to, N-(2-methylpent-1-en-3-yl)benzenamine and Ethyl 2-methylene-3-(phenylamino)butanoate. Further, the products of the method described herein can be used to produce chiral heterocycles and bioactive molecules or materials. A novel chiral copper-ligand nitrosoarene complex is also set forth. 1. A chemical compound having the formula [Cu(Ligand)2(ArNO)2]X2.2. The chemical compound of where in the compound is a chiral copper-nitrosoarene complex having two nitrogen donor ligands and two counter ions.3. A chemical compound comprising:a. a copper atom;b. two nitrosoarenes;c. two nitrogen donor ligands; andd. two counterions.4. The chemical compound of wherein the compound is a chiral copper-nitrosoarene complex.5. The chemical compound of wherein at least one ligand is chiral.6. The chemical compound of wherein the copper atom is bonded to two chiral nitrogen-donor ligands claim 3 , such as BINAM claim 3 , NOBIN claim 3 , and related substituted ligands.7. The chemical compound of wherein the copper atom is bonded to two nitrosoarenes claim 3 , such as nitrosobenzene claim 3 , and related substituted nitrosobenzenes.8. The ...

GRAFTED DINUCLEAR METAL COMPLEXES, AND USE THEREOF AS CELLULAR MICROPARTICLE SENSORS

Novel grafted dinuclear metal complexes having formula (I) or of formula (II) 2. The method of claim 1 , wherein M is selected from Zn claim 1 , Cu claim 1 , Mn claim 1 , Co claim 1 , Ni and Fe.3. The method of claim 1 , wherein:M is Zn or Cu{'sub': 2', 'm, 'X is —(CH)—NH-A, where m=1, A is H, n=1 and p=0 or'}{'sub': 2', 'm, 'X is —(CH)—NH-A, where m=1, A is H, n=2 and p=0 or'}{'sub': '2', 'X is —CH—NHC(O)—R—NH-A, A is H, n=1 and p=0.'}4. The method of claim 1 , wherein X is —(CH)—NH-A claim 1 , —CH—NHC(O)—R—NH-A wherein R is a C-Calkyl group claim 1 , preferably a C-Calkyl group claim 1 , either substituted or unsubstituted claim 1 , linear or branched claim 1 , and A is a fluorophore group.5. The method of claim 1 , wherein the compound having formula (I) is claim 1 , in a first step claim 1 , immobilised on a solid support.6. The method of claim 5 , further comprising the following steps:immobilisation of a compound having formula (I) or (II) on the surface of the solid support,placing in contact with a sample of biological fluid that is likely to contain cellular microparticlescapture of the cellular microparticles on the said compound having formula (I) or (II), anddetection and/or characterisation of the captured cellular microparticles.7. The method of claim 1 , wherein the solid support is activated prior to immobilisation of the compound having formula (I) or (II).8. The method of claim 7 , further comprising the following steps:activation of a solid support,immobilisation of a compound having formula (I) or (II) on a surface of the activated support,placing in contact with a sample of biological fluid that is likely to contain cellular microparticlescapture of the cellular microparticles on the said compound having formula (I) or (II), anddetection and/or characterisation of the captured cellular microparticles.10. The method of claim 1 , wherein the solid support is a microtiter plate claim 1 , a sheet claim 1 , a cone claim 1 , a tube claim 1 , a well ...

RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE

Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc. 3. The probe for detecting HS of claim 1 , wherein the compound represented by any one of Chemical Formulae 1 to 4 is any one selected from(1) 1,4,7,10-tetraazacyclododecane;(2) 1-(anthracen-9-ylmethyl)-1,4,7,10-tetraazacyclododecane;(3) 1,7-dioxa-4,10-diazacyclododecane;(4) 1,4,7,10-tetrakis(anthracen-9-ylmethyl)-1,4,7,10-tetraazacyclododecane;(5) (7S,14R)-5,5,7,12,12,14-hexahexamethyl-1,4,8,11-tetraazacyclotetradecane;(6) 2,5,5,7,9,12,12,14-octamethyl-1,4,8,11-tetraazacyclotetradecane;(7) (1E,7E)-2,5,5,7,9,12,12,14-octamethyl-1,4,8,11-tetraazacyclotetradeca-7,14-diene;(8) (7S,14S)-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane;(9) 6,15-dimethyldocosahydrodibenzo[b,i][1,4,8,11]tetraazacyclotetradecene;(10) ethyl 3-(1,4,7,10-tetraazacyclododecan-1-yl)propanoate;(11) 1,4-bis((1,4,7,10-tetraazacyclotridecan-4-yl)methyl)benzene;(12) 2-(4-nitrobenzyl)-1,4,7,10- ...

METHOD FOR PREPARING HOLE TRANSPORTING MATERIAL FOR PEROVSKITE SOLAR CELL WITH IMPROVED LONG-TERM STABILITY, HOLE TRANSPORTING MATERIAL FOR PEROVSKITE SOLAR CELL PREPARED THEREBY, AND PEROVSKITE SOLAR CELL INCLUDING THE SAME

The present invention relates to a method for preparing a hole transporting material for a perovskite solar cell with improved long-term stability, a hole transporting material for a perovskite solar cell prepared thereby, and a perovskite solar cell including the same, and more particularly, to a method for preparing a hole transporting material for a hole transporting material for a perovskite solar cell, which has high hole mobility, and thus is excellent in power conversion efficiency and may simultaneously realize excellent long-term stability, a hole transporting material for a perovskite solar cell prepared thereby, and a perovskite solar cell which includes the same, and thus may simultaneously realize excellent power conversion efficiency and long-term stability. 2. The hole transporting material of claim 1 , wherein a separate dopant is not comprised in the hole transporting material.6. The hole transporting material of claim 1 , wherein the hole transporting material has a bandgap energy of 1.60 eV or less.7. A method for preparing a perovskite solar cell claim 1 , the method comprising:forming an electron transporting layer on a transparent electrode;forming a perovskite photoactive layer on the electron transporting layer;{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'forming a hole transporting layer by treating the perovskite photoactive layer with a solution comprising the hole transporting material of ; and'}forming a counter electrode on the hole transporting layer.8. The method of claim 7 , wherein a doping process of the hole transporting material is not performed even in any step before and after the forming of the hole transporting layer.9. The method of claim 7 , wherein the solution comprises the hole transporting material at a concentration of 5 mM to 50 mM.10. The method of claim 9 , wherein the solution comprises at least one solvent selected from chlorobenzene claim 9 , toluene claim 9 , xylene claim 9 , chloroform claim 9 , ...

New imidazolium salts and carbene metal complexes based thereon for use as bioanalytical markers for biomolecules

Imidazoliumsalze der allgemeinen Formel I,wobei b Null oder eine ganze Zahl von 1 bis 4 ist; und n, m gleich oder verschieden und jeweils unabhängig voneinander Null oder 1 sind; und X– ein Anion ist; R1 und R2 gleich oder verschieden sind und ausgewählt sind aus der Gruppe von C1-C12-n-Alkylrest und C5-C14-Arylrest, welcher seinerseits gleich oder unterschiedlich substituiert ist durch einen oder mehrere verzweigte oder unverzweigte C1-C3-Alkylreste, R3 ausgewählt ist aus der Gruppe von -COOH und -C(=O)-R'; wobei R' -OR'' mit R'' ausgewählt aus C1-C12-Alkylrest, oder -NH2 ist; R4 Wasserstoff oder R5 ist, wobei R5 ein Imidazolring der Formel II ist,wobei q Null oder 1 und ist; und R6 gleich oder verschieden zu R1 und R2 und ausgewählt aus C1-C12-n-Alkylrest ist. Imidazolium salts of general formula I wherein b is zero or an integer from 1 to 4; and n, m are the same or different and are each independently zero or 1; and X- is an anion; R1 and R2 are the same or different and are selected from the group of C1-C12-n-alkyl radical and C5-C14-aryl radical, which in turn is the same or different substituted by one or more branched or unbranched C1-C3-alkyl radicals, R3 selected is selected from the group of -COOH and -C (= O) -R '; wherein R 'is -OR' 'with R "selected from C1-C12 alkyl radical, or -NH2; R4 is hydrogen or R5, wherein R5 is an imidazole ring of formula II, wherein q is zero or 1 and; and R6 is the same or different from R1 and R2 and is selected from C1-C12-n-alkyl.

Organometallic compounds containing an alkenyl ligand and suitable for use as vapor deposition precursors

Organometallic compounds containing an electron donating group-substituted alkenyl ligand are provided. Such compounds are particularly suitable for use as vapor deposition precursors. Also provided are methods of depositing thin films, such as by ALD and CVD, using such compounds.

Volatile copper(i) complexes for deposition of copper films by atomic layer deposition

The present invention relates to novel 1,3-diimine copper complexes and the use of 1,3-diimine copper complexes for the deposition of copper on substrates or in or on porous solids in an Atomic Layer Deposition process.

Methods for producing copper ethanolamine solutions

Provided are preservation formulations and methods, e.g., formulations for the preservation of wood. In particular, provided are methods for the production of copper monoethanolamine aqueous solutions from metallic copper and monoethanolamine.

Substituted phenylethylene precursor deposition method

A method for using a Cu(hfac) precursor with a substituted phenylethylene ligand to form an adhesive seed layer on an IC surface has been provided. The substituted phenylethylene ligand includes bonds to molecules selected from the group consisting of C 1 to C 6 alkyl, C 1 to C 6 haloalkyl, phenyl, H and C 1 to C 6 alkoxyl. One variation, the α-methylstyrene ligand precursor has proved to be especially adhesive. Copper deposited with this precursor has low resistivity and high adhesive characteristics. The seed layer provides a foundation for subsequent Cu layers deposited through either CVD, PVD, or electroplating. The adhesive seed layer permits the subsequent Cu layer to be deposited through an economical high deposition rate process.

Metal carbene complexes, methods and intermediates for making them and their use in metathesis reactions

Compounds having one of the general formulae:    wherein: M is a metal; Z is selected from the group consisting of oxygen, sulphur, NR"" and PR""; R", R"' and R"" are each a radical independently selected from hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, aryl and heteroaryl, or R" and R"' together form an aryl or heteroaryl radical, each said radical being optionally substituted; R' is either as defined for R", R"' and R"" when included in a compound having the general formula (IA) or, when included in a compound having the general formula (IB), is selected from hydrogen, C 1-6 alkylene and C 3-8 cycloalkylene, the said alkylene and cycloalkylene group being optionally substituted; R 1 is a constraint steric hindrance group having a pK a of at least about 15; R 2 is an anionic ligand; R 3 and R 4 are each hydrogen or a radical selected from, among others, C 1-20 alkyl, C 1-20 alkenyl; R 3 and R 4 together may form a fused aromatic ring system, and y represents the number of sp 2 carbon atoms between M and the carbon atom bearing R 3 and R 4 and is an integer from 0 to 3 inclusive are useful as catalysts for olefin metathesis and atom transfer radical polymerization.

New imidazolium salts and carbene metal complexes based thereon for use as bioanalytical markers for biomolecules

Die vorliegende Erfindung betrifft Imidazoliumsalze, insbesondere Imidazoliumsalze der allgemeinen Formel I sowie die entsprechenden Carben-Metallkomplexe und deren Verwendung als bioanalytische Marker für Biomoleküle. The present invention relates to imidazolium salts, in particular imidazolium salts of the general formula I and the corresponding carbene-metal complexes and their use as bioanalytical markers for biomolecules.

铜-碳烯络合物及其应用

本发明涉及铜－碳烯络合物、其制备方法以及它们在催化偶联反应中的应用。

手性铜络合催化剂组合物及用其进行不对称制备的方法

本发明公开了一种手性铜络合催化剂组合物，它可通过一种通式(1)的光学活性的N-邻羟苯亚甲基氨基醇化合物与一价或二价铜化合物在惰性溶剂中进行反应而得到，其中，R 1 和R 2 表示烷基及类似物，X 1 和X 2 表示氢原子、卤素原子、硝基、烷基、烷氧基、氰基或类似物，和对于每1摩尔通式(1)的光学活性的N-邻羟苯亚甲基氨基醇化合物，一价铜或二价铜化合物的用量低于1摩尔，以及使用所述络合催化剂用来制备光学活性的环丙烷羧酸酯的方法。

置換フェニルエチレン前駆体堆積方法

Organocopper Precursors for Chemical Vapor Deposition

본 발명은 (R 6 COOCR 5 COR 4 )Cu +1 {L} x (식 중, x는 1, 2 또는 3이고, L은 포스핀, 포스파이트 또는 불포화 탄화수소의 중성 배위자이다)를 형성하는데 적절한 중성 배위자 및 아세토아세테이트 유도체를 함유하는 유기 구리 (I) 화합물을 제공한다. R 4 및 R 6 은 각각 독립적으로 C 1 -C 9 알킬 또는 아릴이고, R 5 는 H, F, C 1 -C 9 알킬 또는 아릴이다. CVD 전구체로서 이들 유기 구리 (I) 화합물을 사용하는 경우 열적으로 안정하고 휘발성이 크며 CVD 기술에 의해 고품질의 구리 박막을 제조할 수 있는 장점이 있다. 이들 전구체는 증류가능한 액체 또는 녹는점이 낮은 고체로서 단리되며, 기화 공정 중에 분해되지 않고 낮은 온도에서 금속이나 전도성 기판 위에 구리를 선택적으로 증착시킬 수 있다. The present invention is suitable for forming (R 6 COOCR 5 COR 4 ) Cu +1 {L} x , wherein x is 1, 2 or 3 and L is a neutral ligand of phosphine, phosphite or unsaturated hydrocarbons. An organic copper (I) compound containing a neutral ligand and an acetoacetate derivative is provided. R 4 and R 6 are each independently C 1 -C 9 alkyl or aryl, and R 5 is H, F, C 1 -C 9 alkyl or aryl. The use of these organic copper (I) compounds as CVD precursors has the advantage of being thermally stable, highly volatile and capable of producing high quality copper thin films by CVD techniques. These precursors are isolated as distillable liquids or low melting points solids and can selectively deposit copper on metals or conductive substrates at low temperatures without degradation during the vaporization process. 화학 증착법, CVD, 유기 구리 전구체, 아세토아세테이트, 중성 배위자, 고품질 구리 박막 Chemical vapor deposition, CVD, organic copper precursors, acetoacetates, neutral ligands, high quality copper thin films

Low temperature organometallic deposition of metals

A process for coating metal on a substrate. The process uses organometallic compounds such as (trimethyl)(cyclopentadienyl) platinum in the presence of a reducing fluid such as hydrogen gas to produce high purity films capable of selective deposition on substrates containing, for example, tungsten and silicon. The films are deposited using chemical vapor deposition (CVD) or gas phase laser deposition. The invention also comprises devices made from the process of the invention.