03-05-2018 дата публикации
Номер: US20180117041A1
Принадлежит:
Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described. 2. The compound of claim 1 , wherein:{'sup': 3', '3, 'Ris alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, or phenyl, wherein the phenyl group represented by Ris optionally substituted with one or more groups selected from alkyl, halogen, haloalkyl, alkoxy, haloalkoxy, nitro and —CN;'}{'sup': 4', '5', '4', '5, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Rand Rindependently are halogen, —CN, —OR, —SR, —N(R), —C(O)R, —C(O)OR, —OC(O)O(alkyl), —C(O)O(haloalkyl), —OC(O)R, —C(O)N(R), —OC(O)N(R), —NRC(O)R, —NRC(O)O(alkyl), —S(O)R, —SOR, —SON(R), —NRS(O)R, —NRSOR, —NRC(O)N(R), —NRSON(R), haloalkyl, haloalkoxy, cycloalkoxy, cycloalkyl or alkyl, wherein the alkyl represented by Ror Ris optionally substituted with one or more groups selected from —CN, —OR, —SR, —N(R), ═O, —C(O)R, —C(O)OR, —C(O)O(haloalkyl), —OC(O)R, —OC(O)O(alkyl), —C(O)N(R), —OC(O)N(R), —NRC(O)R, —NRC(O)O(alkyl), —S(O)R, —SOR, —SON(R), —NRS(O)R, —NRSOR, —NRC(O)N(R)and —NRSON(R);'}{'sup': 6', '6, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris H, halogen, —CN, —OR, —SR, —N(R), —C(O)R, —C(O)OR, —OC(O)O(alkyl), —C(O)O(haloalkyl), —OC(O)R, —C(O)N(R), —OC(O)N(R), —NRC(O)R, —NRC(O)O(alkyl), —S(O)R, —SOR, —SON(R), —NRS(O)R, —NRSOR, —NRC(O)N(R), —NRSON(R), haloalkyl, haloalkoxy, cycloalkoxy, cycloalkyl or alkyl, wherein the alkyl group represented by Ris optionally substituted with one or more groups selected from —CN, —OR, —SR, —N(R), ═O, —C(O)R, —C(O)OR, —C(O)O(haloalkyl), —OC(O)R, —OC(O)O(alkyl), —C(O)N(R), —OC(O)N(R), —NRC(O)R, —NRC(O)O( ...
Подробнее
