27-06-2013 дата публикации
Номер: US20130165641A1
The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: 1. A compound represented by the formula (I) or (II):as well as the pharmaceutically acceptable salts, esters and prodrugs thereof, wherein:{'sub': 3', '1', '2', '1', '2, 'claim-text': (a) hydrogen;', {'sub': 3', '3', '1', '6', '2', '6', '2', '6, '(b) —R, wherein Ris substituted or unsubstituted —C-Calkyl, —C-Calkenyl, or —C-Calkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;'}, {'sub': 4', '4, 'claim-text': (i) hydrogen;', '(ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl;', {'sub': '3', '(iii) —R; and'}, {'sub': 5', '5', '3', '12, '(iv) —R, wherein Ris substituted and unsubstituted —C-Ccycloalkyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;'}], '(c) —C(O)R; wherein Ris independently selected from the group consisting of, {'sub': '4', '(d) —C(O)NHR;'}, {'sub': '4', '(e) —C(O)OR; and'}, {'sub': 2', '4, '(f) —S(O)R;'}], 'T is hydrogen, OR, halogen or NRR, wherein Rand Rare each independently selected from{'sub': 1', '2, 'alternatively, Rand Rcan be taken together with the nitrogen they are attached with to form a fused or non-fused, substituted or unsubstituted heterocyclic ring;'}{'sub': '1', 'Yis S or O;'}{'sub': 2', '3', '10', '10', '3', '2', '3, 'Yand Yare each independently selected S, N, O or CR; wherein Ris independently selected from hydrogen, hydroxy, amino, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylamino, substituted or unsubstituted dialkylamino, CF, CN, NO, N, sulfonyl, acyl, aliphatic, and substituted aliphatic;'}{'sub': 1', '3', '2, 'provided that when either Yor Yis S and Yis CH or N, T is not hydrogen;'}{'sub': 1', '2', '3', '10, 'X, Xand Xare each independently selected N or CR;'}Cy is substituted or unsubstituted heterocyclic, or substituted or unsubstituted heteroaryl; (a) hydrogen;', {'sub': '3', '(b) —R;'}, {'sub': '4', ...
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