КОМПОЗИЦИЯ, ИЗМЕНЯЮЩАЯ ЦВЕТ

Изобретение относится к гомогенной композиции, изменяющей свой цвет при воздействии жидкости на водной основе. Композиция включает образующий матрицу компонент, лейкокраситель, кислоту Льюиса на основе соли металла, нейтральное поверхностно-активное вещество (ПАВ) и органический растворитель. Образующий матрицу компонент выбирают из нерастворимых в воде пленкообразующих полимеров и сополимеров. Массовое отношение количества нейтрального ПАВ к количеству лейкокрасителя составляет менее 10. Описываются также многокомпонентный материал, включающий подложку с нанесенным печатанием слоем, содержащим указанную композицию, и два варианта одноразового абсорбирующего изделия, включающего указанный многокомпонентный материал. Предложенная композиция обладает водостойкостью и одновременно хорошей смачиваемостью, что обеспечивает быстрое изменение цвета комплекса лейкокраситель/кислота Льюиса при предотвращении выщелачивания этого комплекса. 4 н. и 12 з.п. ф-лы, 3 пр.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ N-ФЕНИЛМАЛЕИНИМИДА

Использование: в аналитической химии, в частности, для количественного определения N-фенилмалеинимида. Способ заключается в том, что гидролиз анализируемой пробы вещества осуществляют в концентрированной уксусной кислоте, затем обрабатывают полученный раствор смесью концентрированных серной и азотной кислот в объемном отношении 1:1 при температуре 20-25oС в течение 60-65 мин, а потом - водным раствором гидроксида натрия с концентрацией 20-25%, после чего измеряют оптическую плотность полученного раствора при длине волны 400 нм. Техническим результатом является повышение селективности определений, упрощение определений и устранение возможных потерь, расширение области применения. 4 табл.

ТЕСТ-СИСТЕМА В ВИДЕ БИОЛОГИЧЕСКОГО ЧИПА, ОСНОВАННАЯ НА РЕАКЦИЯХ ВЗАИМОДЕЙСТВИЯ АНТИТЕЛА С АНТИГЕНОМ, И ЕЕ ПРИМЕНЕНИЕ

Изобретение относится к химико-фармацевтической промышленности, в частности к вирусологии, биотехнологии, иммунологии, и может быть использовано для определения наличия конкретных компонентов в различных биологических образцах. Сущность изобретения состоит в том, что для анализа биологических образцов используется тест-система в виде биологического чипа, состоящая из не менее одного биочипа, содержащего не менее одного реактора, внутри которого иммобилизованы молекулы-зонды, обладающие структуроспецифичностью или видоспецифичностью к лигандам, по определенному порядку в виде матрицы зондов и/или схемы расположения зондов. При этом указанные лиганды обладают специфичной активностью в реакции антиген/антитело или специфическим сродством к антигену и/или антителу и не вступают в реакцию с антителом-зондом/антигеном-зондом, при этом снижается вероятность перекрестных реакций. Изобретение также относится к способу анализа биологических образцов с использованием вышеупомянутой тест-системы. 2 ...

СПОСОБ ОПРЕДЕЛЕНИЯ НИТРАТА, ВОССТАНОВИТЕЛЬ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

Группа изобретений относится к определению нитрата в различных объектах. Заявляется способ определения нитрата, включающий восстановление нитрата в нитрит раствором соли ванадия (III) в присутствии двух диазотирующихся соединений, одно из которых вводится в аналитическую пробу до добавления восстановителя и вступает в реакцию с нитритом и другими нитрозирующими агентами, присутствующими в пробе. Второе диазотирующееся соединение, преимущественно сульфаниламид, вводится в реакционную смесь после исчерпания имеющегося в аналитической пробе нитрита. Нитрит, образующийся при восстановлении нитрата, вступает в реакцию нитрозирования с обоими нитрозирующимися соединениями. Азокраситель, образующийся при сочетании второго из нитрозирующихся соединений с замещенным нафтиламином, преимущественно с N1-диэтил-N2-нафтилэтилендиамином, определяют колориметрически. Количество образовавшегося красителя зависит от времени реакции восстановления и концентрации ванадия в степени окисления +3. Концентрацию ...

УСТРОЙСТВО ДЛЯ НАНЕСЕНИЯ РАСТВОРА НА СУБСТРАТ

Задачей изобретения является обеспечение возможности точного покрытия материала широкими или узкими полосками раствора посредством головки экструдера для щелевого покрытия. Головка экструдера включает, по меньшей мере, горловину со сливными носиками, проходящими за пределы поверхности или корпуса головки экструдера. Головка экструдера выполнена с возможностью предотвращения утечки раствора из нее. Верхняя и нижняя части головки экструдера, ограничивающие горловину, выполнены предпочтительно по существу плоскими и зеркальными изображениями друг друга. Сливные носики предпочтительно размещены в непосредственной близости к материалу, на который предстоит осадить раствор. Раствор, проходящий через горловину головки экструдера, направляется к ленте ткани и осаждается по существу узкой или широкой полосой постоянной толщины. Часто раствор включает раствор типа реагента. Покрытие раствором обычно высыхает на субстрате. Затем высушенное изделие может применяться при производстве тестирующей полоски ...

СПОСОБ ЭКСПРЕСС-ОБНАРУЖЕНИЯ ВЕЩЕСТВ НА ТВЕРДЫХ ПОВЕРХНОСТЯХ

Использование: в аналитической химии, при колориметрическом обнаружении биологических агентов на твердых поверхностях. Сущность: на исследуемую поверхность наносят по крайней мере один реагент с помощью аэрозольной упаковки. В качестве первого реагента используют раствор производного диоксиксантенового красителя в полярном органическом растворителе при рН 1-3, а в качестве второго реагента - водный раствор уксусной кислоты. В качестве раствора производного диоксиксантенового красителя в полярном органическом растворителе используют смесь 0,3-0,6% (мас.) раствора эозина БА или флоксина в ацетоне и 0,75% (мас.) водного раствора хлористого водорода в соотношении 70: 1. Технический результат изобретения заключается в экспресс-обнаружении биологических агентов на твердых поверхностях без использования дополнительного оборудования. 2 з.п. ф-лы, 4 табл.

СПОСОБ ИЗГОТОВЛЕНИЯ СТЕРИЛИЗОВАННОГО И ТАРИРОВАННОГО МЕДИЦИНСКОГО УСТРОЙСТВА НА ОСНОВЕ БИОСЕНСОРА (ВАРИАНТЫ)

Изобретение относится к области изготовления медицинских устройств. Способ изготовления стерилизованного и тарированного медицинского устройства на основе биосенсора (например, медицинского устройства с объединенными в одно целое биосенсором и ланцетом), содержащее реагент биосенсора (например, реагент биосенсора из специфического фермента для анализируемого вещества и медиатора). Стерилизацию осуществляют, например, гамма-излучением. Затем тарируют реагент биосенсора стерилизованного медицинского устройства на основе биосенсора. Другой способ изготовления стерилизованного и тарированного медицинского устройства на основе биосенсора включает в себя вначале сборку и упаковывание множества медицинских устройств с реагентом биосенсора, затем стерилизацию облучением для создания множества стерилизованных, упакованных медицинских устройств на основе биосенсора. После этого тарируют стерилизованные и упакованные медицинские устройства на основе биосенсора. Тарирование можно выполнять, используя ...

СПОСОБ ОБНАРУЖЕНИЯ АНИОННЫХ ПОВЕРХНОСТНО-АКТИВНЫХВЕЩЕСТВ В ВОДОСОДЕРЖАЩЕЙ СРЕДЕ

Использование: для определения анионных поверхностно-активных веществ (АПАВ) в водных средах, например в молоке, сокосодержащих напитках, соках, любых безалкогольных, алкогольных напитках. Сущность изобретения: вводят в исследуемую пробу индикатор - органический флуоресцентный краситель, содержащий четвертичный атом азота или смесь сильной неорганической кислоты с органическим флуоресцентным красителем, содержащим амино и/или алкиламино группу, добавляют полифосфатный буфер, имеющий высокую ионную силу и рН 2-5, экстрагируют полученные окрашенные соединения органическим растворителем, измеряют интенсивность его флуоресценции и/или окраски и судят по их величине о содержании АПАВ. Техническим результатом является расширение видов анализируемых растворов, снижение предела обнаружения и повышение точности определения. 12 з.п. ф-лы.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ ИОНОВ МЕДИ

Изобретение относится к измерительной технике. В способе анализируемую пробу обрабатывают роданидом калия и раствором N-этил-N(2-гидроксиэтил)-1,4-фенилендиаммония сульфат моногидрата, в продукт реакции добавляют ацетон, выжидают 10 минут, разбавляют водой и измеряют оптическую плотность окрашенного раствора на длине волны 513 нм. Технический результат - повышение чувствительности определения ионов меди. 2 табл.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ ЦИАНИДОВ

Изобретение относится к аналитической химии и может быть использовано при количественном определении цианид-аниона в экстрактах, полученных из воды, грунта, проб воздуха, смывов с поверхностей различных объектов. Изобретение также может быть использовано при проведении мероприятий по мониторингу окружающей среды, мероприятий по защите от оружия массового поражения, для определения полноты дегазации и уничтожения веществ, выделяющих цианид-анионы, а также в криминалистике. Способ количественного определения цианидов в водной и водно-спиртовых пробах включает обработку пробы щелочными растворами люминола, гемина и перекисным соединением с последующим замером интенсивности хемилюминесценции, причем в качестве перекисного соединения используется пара-нитробензциангидрин, получаемый в результате обработки пробы пара-нитробензильденидом, обработку осуществляют при 293 К в течение одной минуты при объемном соотношении растворов пробы, люминола, гемина и пара-нитробензальдегида 1:2:1:1. Достигается ...

Способ количественного определения производных дибензазепинов (группы ипраминов)

Изобретение относится к фармацевтической промышленности и может быть использовано для количественного определения производных дибензазепинов (группы ипраминов) в субстанциях. Навески порошков имипрамина гидрохлорида, кломипрамина гидрохлорида, тримипрамина гидрохлорида и дезипрамина 0,025 г помещают в мерные колбы емкостью 50 мл, растворяют сначала в 30 мл метанола, выдерживают при комнатной температуре до полного растворения, а затем доводят метанолом до метки объемы колб, в мерные колбы емкостью 20 мл точно отмеривают 2,0, 3,0, 4,0, 5,0, 6,0 мл приготовленных растворов имипрамина гидрохлорида, кломипрамина гидрохлорида, тримипрамина гидрохлорида и дезипрамина, прибавляют каплями в течение 5-6 минут 5,5 мл метанольного раствора сульфата никеля (II) в аммиаке, через 2-3 минуты выпадает голубой осадок комплексной соли, колбы доводят до метки метанолом, содержимое мерных колб переносят в делительные воронки, прибавляют 10 мл хлороформа и встряхивают, хлороформный слой окрашивается в синий ...

СПОСОБ ОПРЕДЕЛЕНИЯ СТЕПЕНИ ТЯЖЕСТИ ОСТРОГО ИНФЕКЦИОННОГО МОНОНУКЛЕОЗА, ВЫЗВАННОГО ВИРУСОМ ЭПШТЕЙНА - БАРР У ДЕТЕЙ

Изобретение относится к области медицины, а именно к детским инфекционным болезням, и может быть использовано для определения степени тяжести острого инфекционного мононуклеоза, вызванного вирусом Эпштейна-Барр у детей. Способ определения степени тяжести острого инфекционного мононуклеоза, вызванного вирусом Эпштейна-Барр, заключается в том, что у больных инфекционным мононуклеозом дополнительно определяют в сыворотке крови содержание малонового диальдегида, и при содержании малонового диальдегида в сыворотке крови в пределах от 1,10 до 6,10 ммоль/л оценивают тяжесть состояния как легкую, при содержании малонового диальдегида в пределах от 6,11 до 10,15 ммоль/л оценивают тяжесть состояния как среднетяжелую, а при содержании малонового диальдегида не менее 10,16 ммоль/л оценивают тяжесть состояния как тяжелую. Изобретение направлено на повышение достоверности и расширение функциональных возможностей диагностики степени тяжести острого инфекционного мононуклеоза, вызванного вирусом Эпштейна-Барр ...

СПОСОБ КИНЕТИЧЕСКОГО ОПРЕДЕЛЕНИЯ СЕЛЕНА

Изобретение относится к аналитической химии и может быть использовано для анализа промышленных и природных объектов, а также в веществах особой чистоты. Способ кинетического определения селена основан на его каталитическом действии на реакцию восстановления марганца в азотнокислой среде при рН 1-7. Чувствительность определения 3,2 • 10-8%. Определению не мешают ионы натрия, калия, золота, 60000-кратные меди, 40000-кратные железа. Способ обладает высокой чувствительностью, прост, не требует дорогостоящих реактивов.

ИНДИКАТОРНАЯ ТРУБКА

Индикаторная трубка для контроля вредных веществ, содержащая цилиндрический прозрачный герметично запаянный стеклянный корпус с каналом для прокачивания контролируемой среды, частично заполненным индикаторным наполнителем, изменяющим цвет при прохождении через него определяемых вредных веществ, отличающаяся тем, что она снабжена прикрепленной к наружной поверхности корпуса пленочной шкалой, имеющей по меньшей один диапазон измерений, при этом шкалу на корпусе трубки размещают так, что ее начало совпадает с границей слоя индикаторного наполнителя со стороны взаимодействия трубки с окружающей средой.

ФОТОКОЛОМЕТРИЧЕСКАЯ ГОЛОВКА ЛЕНТОЧНОГО ГАЗОАНАЛИЗАТОРА

... 1. Фотоколометрическая измерительная головка ленточного газоанализатора, содержащая корпус с патрубками подвода и отвода анализируемой газовой смеси, реакционную газовую камеру с размещенной в ней индикаторной лентой, с одной стороны которой установлен осветительный светодиод, а с другой - фотодиод, отличающаяся тем, что реакционная камера содержит опорную подложку с окном для выхода анализируемой газовой смеси, на которой размещена индикаторная лента, и систему прижима индикаторной ленты, включающую в себя прижимную плашку с окном для входа анализируемой газовой смеси, выполненную с возможностью перемещения в корпусе при помощи связанного с ней механизма перемещения, при этом осветительный диод и патрубок подвода анализируемого газа установлены в прижимной плашке.2. Фотоколометрическая измерительная головка ленточного газоанализатора по п. 1, отличающаяся тем, что механизм перемещения выполнен в виде прикрепленной к прижимной плашке втулки, подпружиненной относительно корпуса, и вала с ...

Способ концентрирования микроэлементов

Изобретение относится к аналитической химии и может быть использовано в практике аналитических, агрохимических, медицинских лабораторий. Осуществляют концентрирование микроэлементов для последующего аналитического определения путем соосаждения с диантипирилметаном, образующим в системе вода - минеральная кислота - тиоцианат аммония коллектор дитиоцианат диантипирилметания. Соосаждение микроэлентов ведут при оптимальной концентрации ионов водорода в интервале 0,05-2,0 моль/л и тиоцианат-ионов в интервале 0,05-2,0 моль/л. Обеспечивается уменьшение токсичности и повышение устойчивости анионного фона водного раствора к действию внешних факторов, повышение эффективности извлечения и расширение перечня извлекаемых ионов металлов. 2 табл., 1 пр.

УСТРОЙСТВО ДЛЯ АНАЛИЗА ЖИДКОСТЕЙ

Устройство для анализа жидкостей, характеризующееся тем, что оно содержит емкость с горловиной и без дна, замкнутый эластичный рукав, выполненный из прозрачного полупроницаемого материала, часть которого размещена внутри емкости между ее горловиной и открытым дном с зазором между замкнутым рукавом и горловиной, установленный с зазором внутри замкнутого рукава шарик из магнитомягкой стали и размещенный на горловине емкости постоянный кольцевой магнит, при этом на внутренней части замкнутого рукава расположен слой реагента.

СПОСОБ КОЛИЧЕСТВЕННОГО СПЕКТРОФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ И ИДЕНТИФИКАЦИИ ДИНИТРИЛА ОРТОХЛОРБЕНЗИЛИДЕНМАЛОНОВОЙ КИСЛОТЫ В ЭКСТРАКТАХ

Использование: при анализе органических соединений. Спиртовый экстракт смешивают с 35-45% водным раствором гидроксида натрия и 0,04-0,6% спиртовым раствором метадинитробензола, а спектрофотометрирование реакционной смеси проводят через 20 мин. 2 з.п.ф-лы, 3 ил., 1 табл.

СПОСОБ ОПРЕДЕЛЕНИЯ ФЕНИЛГИДРАЗИНА

Сущность изобретения: способ предназначен для определения фенилгидразина в присутствии бисульфат-ионов в сточных водах. В анализируемую пробу вводят смешивающийся с водой органический растворитель в количестве, достаточном для растворения конечного продукта реакции, затем добавляют последовательно избытки альдегида и 4-хлор-5,7-динитробензофуразана. Раствор выдерживают для получения постоянной окраски и фотометрируют в области полосы поглощения с максимумом при 510 нм.

СПОСОБ ОПРЕДЕЛЕНИЯ НОВОКАИНАМИДА В ОБЪЕКТАХ БИОЛОГИЧЕСКОГО ПРОИСХОЖДЕНИЯ

Использование: в аналитической химии при проведении химико-токсилогических, судебно - химических и клинических исследований. Сущность изобретения: анализируемую пробу обрабатывают хлорной кислотой, доводят pH до 6 - 11, пропускают через хроматографическую колонку с силикагелем при соотношении массы силикагеля в граммах к объему пробы в мл (0,4 - 0,5) : (5 - 6) при содержании нокаинамида 10 - 100 мкг в пробе с последующим фотоколориметрированием окрашенного раствора. Относительная ошибка ± 3.8 % , время анализа 8 ч. 7 табл.

СПОСОБ ОПРЕДЕЛЕНИЯ О-ТОЛУИДИНА В КРОВИ

Изобретение относится к аналитической химии. Сущность изобретения: количественное определение о-толуидина в крови проводится предварительной обработкой проб хлороформом с последующим кипячением в течение 15 с и проведения газохроматографического анализа. Хроматография проводится путем вкладывания анализируемых проб крови после предварительной обработки в колонку с неподвижной жидкой фазой 3% OV-1, нанесенную на сорбент хроматон N-Супер. Количественное определение о-толуидина проводят методом абсолютной калибровки. 1 ил., 4 табл.

СПОСОБ ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ ТИТАНА

Сущность изобретения: переводят титан в ионный ассоциат с бромпирогалловым красным (БПК) и кристаллическим фиолетовым (КФ) и флотацией его при pH 0,75 - 0,85 толуолом с последующим разрушением этанолом с выделением эквивалентного титану количества кристаллического фиолетового. Количественную регистрацию осуществляют фотометрированием толуольно-этанольного экстракта при 590 нм. Условия образования ассоциата (1, 6-2,4)·10-4 М концентрация БПК и (1,2-1,6)·10-4 М КФ. 1 табл.

ВОЙСКОВОЙ ПРИБОР ХИМИЧЕСКОЙ РАЗВЕДКИ АВТОМАТИЧЕСКИЙ

Изобретение относится к области контроля загрязнения окружающей среды, а именно к средствам для обнаружения и полуколичественного определения отравляющих веществ, аварийно химически опасных веществ в воздухе и в капельно-жидком состоянии на поверхностях различных объектов. Прибор химической разведки содержит корпус с откидной крышкой, образующие в закрытом положении футляр с рычажной защелкой, и размещенные в корпусе источник электропитания, побудитель расхода воздуха, воздуховод с каналом для забора прокачиваемого воздуха, гнездо для размещения индикаторного средства, через которое осуществляется прокачивание воздуха побудителем расхода воздуха, устройство подогрева индикаторного средства, включающее датчик температуры и нагревательный элемент, а также блок управления работой прибора, содержащий панель управления и индикаторную панель, при этом в качестве индикаторного средства используется индикаторный плоский элемент, причем прибор дополнительно содержит модуль предварительного нагрева ...

СПОСОБ ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ ЖЕЛЕЗА (III) В РАСТВОРАХ ЧИСТЫХ СОЛЕЙ

Изобретение относится к области аналитической химии, применительно к анализу растворов чистых солей, содержащих железо (III) в очень малой концентрации. Способ включает переведение железа (III) в комплексное соединение с глицилалюминоном в слабокислой среде, причем к раствору железа (III) с рН 3,6-6,2 добавляют 280-340-кратное количество глицилалюминона, 0,03-0,2 мл раствора поверхностно-активного вещества, полученного путем добавления к 0,2 мл моноалкилфенилового эфира полиэтиленгликоля на основе полимердистиллята воды до 100 мл, и воды до 10 мл объема с последующим нагреванием на водяной бане при температуре 80-98°С в течение 3-8 минут. Достигается повышение чувствительности анализа.

КОЛИЧЕСТВЕННОЕ ОПРЕДЕЛЕНИЕ 2-ПИРИДИЛМАЛЕИНАМИДОКИСЛОТЫ

Изобретение относится к аналитической химии, а именно к способам количественного определения 2-пиридилмалеинамидокислоты (ПМАК). Способ основан на предварительном гидролизе ПМАК с последующим фотометрированием полученного раствора. Технический результат: уменьшение времени определения ПМАК и устранение нагревания пробы при высокой температуре. Водный раствор ПМАК обрабатывают 6 М раствором уксусной кислоты и сразу же измеряют оптическую плотность полученного раствора на характеристической длине волны поглощения 2-аминопиридина - одного из продуктов гидролиза ПМАК. 4 табл.

ИНДИКАТОРНЫЙ СОСТАВ ДЛЯ ОПРЕДЕЛЕНИЯ РЕНИЯ (VII) ВВОДНЫХ РАСТВОРАХ

Изобретение относится к аналитической химии (индикаторным составам) и может быть использовано для определения рения (VII) в водных растворах, в частности сточных водах и производственных растворах. Индикаторный состав для определения рения (VII) в водных растворах содержит сорбент-анионит АВ-17-10П, бриллиантовый зеленый, фосфорную кислоту и воду при следующем содержании компонентов, мас.%: анионит АВ-17-10П 0,40, бриллиантовый зеленый 0,004, фосфорная кислота 1,57, вода - остальное. Достигается повышение чувствительности и экспрессности определения рения (VII), улучшение селективности методики. 2 табл.

ИНДИКАТОРНЫЙ СОСТАВ ДЛЯ ОПРЕДЕЛЕНИЯ ПАЛЛАДИЯ (II)В ВОДНЫХ РАСТВОРАХ

Изобретение относится к аналитической химии (индикаторным составам) и может быть использовано для определения палладия (II) в водных растворах, в частности в сточных водах и производственных растворах. Достигается расширение линейного диапазона определяемых концентраций палладия (II) в водных растворах, повышение чувствительности и улучшение селективности методики. Индикаторный состав для определения Pd (II) в водных растворах содержит азотную кислоту, нитрозо-R-соль, воду и сорбент - анионит АНС-80 - при следующем соотношении компонентов, мас. %: анионит АНС-80 0,4; азотная кислота 0,001; нитрозо-R-соль 0,4; вода остальное. 3 табл.

ПРИБОР ХИМИЧЕСКОЙ РАЗВЕДКИ

Полезная модель относится к области контроля загрязнения окружающей среды, а именно к средствам для обнаружения и оценки степени заражения воздуха, грунта, поверхностей, в частности вооружений и военной техники, отравляющими веществами (ОВ) и сильнодействующими ядовитыми веществами (СДЯВ). Прибор химической разведки содержит корпус, состоящий из основания и крышки, образующих при соединении коробку с накидным замком. В корпусе размещены: индикаторные средства в виде набора индикаторных трубок; побудитель расхода воздуха и устройство подогрева индикаторных трубок. Устройство подогрева индикаторных трубок содержит корпус с гнездами для установки индикаторных трубок и нагревательный элемент, в качестве которого использован электронагреватель. Устройство подогрева индикаторных трубок также содержит: автономный источник электропитания; датчик температуры; микроконтроллер, управляющий работой электронагревателя; средство включения-выключения нагревательного элемента. Технический результат заключается в снижении травмоопасности устройства, в упрощении эксплуатационного обслуживания, повышении надежности устройства и увеличении срока службы. 23 з.п. ф-лы, 7 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 180 990 U1 (51) МПК G01N 21/78 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 21/78 (2018.05) (21)(22) Заявка: 2017138697, 07.11.2017 (24) Дата начала отсчета срока действия патента: Дата регистрации: 03.07.2018 (45) Опубликовано: 03.07.2018 Бюл. № 19 Адрес для переписки: 198260, Санкт-Петербург, а/я 65, Пантюхиной А.М. 1 8 0 9 9 0 U 1 (56) Список документов, цитированных в отчете о поиске: Мясников В.В. Защита от оружия массового поражения, М.: Воениздат, 1989, с.241-245. RU 2029288 C1, 20.02.1995. SU 138076 A1, 01.01.1961. CN 202911609 U, 01.05.2013. (54) ПРИБОР ХИМИЧЕСКОЙ РАЗВЕДКИ (57) Реферат: Полезная модель относится к области контроля загрязнения окружающей среды, а именно к средствам для обнаружения и ...

СПОСОБ ОПРЕДЕЛЕНИЯ ИЗОПРОПИЛНИТРАТА В СТОЧНОЙ ВОДЕ

Использование: аналитическая химия, а именно спектрофотометрические способы определения изопропилнитрата в сточных водах рабочей зоны предприятий химической промышленности. Сущность: способ заключается в том, что пробу обрабатывают цветореагентом - водным раствором смеси салициловой кислоты и салицилата натрия, взятых в массовом соотношении 1 : (10-11). Затем раствор выпаривают досуха, остаток растворяют в концентрированной серной кислоте, добавляют воду, раствор аммиака и полученный раствор фотометрируют в области полосы поглощения с максимумом при 360 нм. Способ характеризуется экспрессностью и дешевизной. 1 табл., 1 ил.

СПОСОБ ОПРЕДЕЛЕНИЯ ЩЕЛОЧНОГО ЧИСЛА МОТОРНЫХ МАСЕЛ

Способ применим для оценки качества моторных масел и может быть использован для определения их пригодности при эксплуатации техники. Анализируемую капельную пробу масла вводят в смесь, состоящую из (71±1)% дистиллированной воды и (29±1)% растворителя, причем растворитель состоит из 50% толуола и 50% изопропанола, а в качестве индикатора используют фильтровальную бумагу "синяя лента", пропитанную 0,5%-ным водным раствором бромтимолового синего. Достигается повышение точности и упрощение анализа.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ ДИФЕНИЛАМИНОХЛОРАРСИНА

Использование: аналитическая химия, а именно спектрофотометрические способы определения дифениламинохлорарсина. Сущность: способ заключается в том, что к пробе добавляют 2,0±0,2%-ный раствор ароматического амина в диполярном растворителе и смесь 30±1%-ной перекиси водорода с 0,0020±0,0002 N натриевой или калиевой щелочью. При смешивании объемное соотношение раствора перекиси водорода и раствора щелочи составляет 2:1, а объемное соотношение растворов пробы, ароматического амина и смеси составляет 25:1:1 соответственно. В качестве ароматического амина преимущественно используют о-толуидин, а в качестве апротонного растворителя используют ацетон. Окрашенный продукт фотометрируют при 430±2 нм. Достигаемый результат: высокая чувствительность, точность определения, расширение диапазона определяемых концентраций вещества. 1 з.п. ф-лы, 3 табл.

СПОСОБ ОПРЕДЕЛЕНИЯ АКТИВНОСТИ ФОСФОЛИПАЗЫ Д

Назначение: биохимия, может быть использовано в клинической медицине, в микробиологической и пищевой промышленности, при контроле биотехнологических процессов при получении физиологически активных соединений и фосфолипидов. Сущность изобретения: активность фосфолипазы D определяют по количеству фосфатидной кислоты, образовавщейся в результате энзиматического расщепления фосфатидилхолина фосфолипазой D. Расщепление фосфатидилхолина осуществляют путем обработки проб красителем Viktoria Blua R в водном насыщенном растворе мочевины. Окрашенный комплекс фосфатидной кислоты подвергают разделению на фазы. Количество образовавшейся фосфатидной кислоты осуществляют спектрофотометрически в органической фазе. 1 ил.

ФОТОКОЛОРИМЕТРИЧЕСКИЙ ГАЗОАНАЛИЗАТОР

Использование: в аналитической технике, в частности в фотоколориметрическом газоанализаторе для измерения концентрации вредных веществ в воздухе. Сущность изобретения: газоанализатор содержит индикаторный элемент, два светоизлучающих диода, основной и дополнительный фотоприемники, выполненные в виде планарных фотодиодов, регистрирующее устройство. Также в газоанализаторе содержится тонкое плоское стекло со светоотражающим покрытием и оптическая ловушка. Дополнительный фотодиод через усилитель отрицательной обратной связи подключен ко входам светодиодов. Такое подключение позволяет осуществить управление интенсивностью их излучения, которая может меняться в зависимости от изменения различных внешних факторов. При этом сигнал от основного фотодиода будет определяться только изменением параметров индикаторного элемента, что повышает точность газоанализатора. 2 ил.

СПОСОБ ОПРЕДЕЛЕНИЯ ОРТОНИТРОАНИЛИНА

Использование: в аналитической химии органических соединений при анализе очищенных сточных вод. Сущность изобретения: анализируемую пробу обрабатывают смесью бутилацетата и дибутилфталата при их соотношении (мол.дол.) 0,4 0,6 0,4 0,6, после расслаивания отбирают органический слой и фотометрируют его. 2 табл.

Способ определения толщины слоев неорганических веществ с помощью фотоколориметрического метода

Изобретение относится к способу определения толщины слоев неорганических веществ и может быть использовано для оценки чистоты поверхности изделий, при исследованиях в области химической кинетики. Способ определения толщины слоев неорганических веществ с помощью фотоколориметрического метода включает перевод вещества слоя с подложки в раствор путем растворения в подходящем растворителе с образованием комплекса. Предварительно для данного комплекса строят градуировочную кривую зависимости пропускания от концентрации ионов анализируемого химического элемента для определения содержания вещества в растворе. По градуировочной кривой и полученному спектру пропускания анализируемого вещества определяют его концентрацию в растворе, зная которую, с учетом измеренных площади подложки и массы раствора, рассчитывают массовый эквивалент толщины слоя. Техническим результатом является обеспечение доступного и надежного способа измерения массовой толщины слоев до 1⋅10-10г/м2. 2 ил.

ТЕСТОВАЯ МИКРОСХЕМА И СПОСОБ ЕЕ ИЗГОТОВЛЕНИЯ

Изобретение относится к тестовой микрожидкостной микросхеме листовой формы и способу ее изготовления. Тестовая микрожидкостная микросхема листовой формы: первый слой на стороне передней поверхности и второй слой на стороне задней поверхности; причем первый слой и второй слой примыкают друг к другу; при этом один из первого слоя и второго слоя имеет секцию А приема жидкости; причем первый слой имеет по меньшей мере секцию В подтверждения детектирования; причем второй слой имеет по меньшей мере секцию D потока жидкости, примыкающую к секции В подтверждения детектирования, и проход Е для жидкости, соединенный с секцией D потока жидкости; при этом, в случае когда секция А приема жидкости предусмотрена в первом слое, секция А приема жидкости расположена на расстоянии от секции В подтверждения детектирования; при этом, когда тестовая жидкость образца падает в секцию А приема жидкости, тестовая жидкость проходит через секцию А приема жидкости, проход Е для жидкости и секцию D потока жидкости в ...

Состав тест-россыпи для определения сульфит-ионов в водных растворах, воздушных средах и биологических объектах

Изобретение относится к области аналитической химии, почвоведения и экологии. Предложен состав тест-россыпи для определения сульфит-ионов в водных растворах, воздушных средах и биологических объектах, характеризующийся тем, что содержит 4-[(4-аминофенил)(4-имино-2,5-циклогексадиен-1-илиден)метил]-2-метиланилина гидрохлорид в мольном соотношении 1:1, формалин, диоксид кремния, каолин, полилактид и костру льна при следующем соотношении компонентов, мас. %: 4-[(4-аминофенил)(4-имино-2,5-циклогексадиен-1-илиден)метил]-2-метиланилина гидрохлорид в мольном соотношении 1:1 - 0,2-1,0; формалин - 0,02-0,1; диоксид кремния - 6,0-8,0; каолин - 2,0-6,0; полилактид - 1,0-4,0; костра льна - до 100. Техническим результатом изобретения является изготовление состава, позволяющего проводить экспресс-анализ проб на месте отбора, а также сохранять стабильность и физико-химические характеристики в течение длительного времени при повышении чувствительности и точности определения концентрации сульфит-ионов. 5 ...

2,6-ДИФЕНИЛ-4- (4-ДИМЕТИЛАМИНОСТИРИЛ)ПИРИЛИЯ-ХЛОРИД В КАЧЕСТВЕ АНАЛИТИЧЕСКОГО РЕАГЕНТА ДЛЯ КОЛИЧЕСТВЕННОГО ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ АНИОННЫХ ПОВЕРХНОСТНО-АКТИВНЫХ ВЕЩЕСТВ

Использование: в аналитической химии в качестве реагента для количественного фотометрического определения анионных поверхностно-активных веществ (АПАВ). Сущность изобретения: продукт 2,6-дифенил-4-(4-диметиламиностирил)-пирилий хлорид. Б.Ф. C27H24ClO 228°С (разложение). Реагент 1:4-метил-2, 6-дифенилпирилий хлорид. Реагент 2: n-диметиламинобензальдегид. Условия процесса: в среде уксусного ангидрида при 106-110°С в течение 35 ч с последующей выдержкой при комнатной температуре 2сут. Позволяет повысить чувствительность определения АПАВ, расширить круг определяемых АПАВ и проводить как экстракционное, так и безэкстракционное определение АПАВ. 12 табл.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ ДИМАЛЕИНИМИДОВ

Изобретение относится к аналитической химии, а именно к способам количественного определения дималеинимидов. Способ заключается в том, что пробу дималеинимида в концентрированной азотной кислоте обрабатывают реагентами с последующим измерением оптической плотности полученного раствора при 400 нм, при этом в качестве реагентов используют 10% раствор нитрата калия в концентрированной серной кислоте (раствор I) и 15-20% водный раствор гидроксида натрия (раствор II), а обработку пробы анализируемого вещества ведут сначала раствором I при 20-25°С в течение 30 мин, а затем раствором II. Техническим результатом является повышение чувствительности. 3 табл.

СПОСОБ ОПРЕДЕЛЕНИЯ ЭЛЕКТРОНОНАСЫЩЕННОГО АРОМАТИЧЕСКОГО АМИНА, ЯВЛЯЮЩЕГОСЯ МАРКЕРОМ СОДЕРЖАНИЯ АНАЛИТА В БИОЛОГИЧЕСКОЙ ЖИДКОСТИ, И СРЕДСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ

Использование: в медицине, для определения аналита при помощи образования гетерополисинего. Сущность: аналит превращают с веществом, которое приводит к электрононасыщенному амину, который вступает в контакт с труднорастворимой солью гетерополикислоты. Средство для осуществления способа содержит труднорастворимую соль гетерополикислоты в количестве, достаточном для перевода всего амина в гетерополисиний. 2 с и 2 з. п. ф-лы, 7 ил., 4 табл.

СПОСОБ, СРЕДСТВО, ТЕСТ-СИСТЕМА ДЛЯ КОЛОРИМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ АНАЛИТА И НИТРОЗОАНИЛИНОВЫЕ СОЕДИНЕНИЯ

Изобретение может быть использовано для обнаружения и определения веществ в различных испытуемых материалах. Способ определения аналита включает ферментативное окисление аналита с помощью PQQ-зависимой дегидрогеназы в присутствии акцептора электронов. Акцептор электронов - обогащенные электронами ароматические нитрозосоединения, которые восстанавливают до иминосоединения при окислении аналита. Восстановленный акцептор обнаруживают путем цветового проявления. В случае, если акцептор не способен к цветовому проявлению, обнаружение проводят в присутствии неокислительного окрашивающего индикатора для иминосоединений или в присутствии лейкокрасителя. При этом лейкокраситель окисляется в присутствии иминосоединений до красителя. Средство для способа содержит PQQ-зависимую дегидрогеназу и прямой акцептор электронов - обогащенные электронами ароматические нитрозосоединения, неокислительный окрашивающий индикатор для иминосоединений или лейкокраситель. Тест-система для способа представляет собой ...

СПОСОБ КИНЕТИЧЕСКОГО ОПРЕДЕЛЕНИЯ МЕДИ И КОБАЛЬТА ПРИ СОВМЕСТНОМ ПРИСУТСТВИИ

Использование: в аналитической химии. Для определения меди и кобальта используют реакцию окисления индигокармина пероксидом водорода, катализируемую солями меди (II) в кислой и щелочной средах, а солями кобальта (II) - только в щелочной среде. Технический результат - снижение трудоемкости. 3 ил., 3 табл.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ СЕРОУГЛЕРОДА В ВОЗДУХЕ

Использование: в аналитической химии при контроле за содержанием сероуглерода в воздухе промышленных предприятий. Сущность изобретения: анализируемый воздух аспирируют через раствор диэтиламина в спирте концентрации 1,5%. Отбирают пробу раствора, вводят в нее спиртовой раствор ацетата меди до концентрации ацетата меди 0,02%, выдерживают полученный раствор не менее 5 мин и фотометрируют его в области полосы поглощения с максимумом при 400 нм. Содержание сероуглерода определяют по предварительно построенному калибровочному графику, для построения которого используют раствор бутилксантогената калия в качестве раствора с известным содержанием сероуглерода. При приготовлении стандартных растворов учитывают, что одномолярный раствор бутилксантогената калия соответствует одномолярному раствору сероуглерода. 1 табл.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ ФТОРАНГИДРИДА ДИИЗОПРОПИЛОВОГО ЭФИРА МЕТИЛФОСФОНОВОЙ КИСЛОТЫ

Изобретение относится к области аналитической химии. Определение фторангидрида диизопропилового эфира метилфосфоновой кислоты проводят 15%-ной перекисью водорода в слабощелочной среде (рН=7-8). В качестве ароматического амина используют 2,5%-ный ацетоновый раствор о-толидина. Технический результат - улучшение основных метрологических характеристик способа и повышение производительности массового анализа исследуемых проб в 3-4 раза. 3 табл.

ИНДИКАТОРНЫЙ СОСТАВ ДЛЯ ОПРЕДЕЛЕНИЯ ЗОЛОТА (III) В ВОДНЫХ РАСТВОРАХ

Изобретение относится к аналитической химии (индикаторным составам) и может быть использовано для определения золота (III) в водных растворах, в частности в сточных и производственных растворах. Индикаторный состав для определения золота (III) в водных растворах содержит хлористоводородную кислоту, органический реагент - родамин 6Ж, в качестве сорбента - высокоосновной анионит АВ-17-8, и воду при следующем соотношении компонентов, мас.%: Анионит АВ-17-8 2,0 Хлористоводородная кислота 0,01-0,1 Родамин 6Ж 0,01 Вода Остальное. Достигается повышение чувствительности определения и улучшение селективности методики. 4 табл.

СПОСОБ ОПРЕДЕЛЕНИЯ ЖИРНЫХ КАРБОНОВЫХ КИСЛОТ C5- C7 И ИХ СМЕСЕЙ

Использование - в аналитической химии. Сущность изобретения: состоит в экстракции кислот из слабокислых сред смесью толуола и 1 - 2 проц. об. гексанола или гептанола обработки экстракта толуольным раствором соли высшего четвертичного амониевого основания (ЧАО) с п-нитрофенолом и последующего фотометрирования. Концентрацию кислот определяют по убыли оптической плотности органической фазы по сравнению с оптической плотностью исходного раствора соли ЧАО с п-нитрофенолом. 1 табл.

Способ определения свинца (II) в водных и биологических образцах

Изобретение относится к способу определения свинца(II) в водных объектах окружающей среды и биологических образцах. Способ включает приготовление полимерной сенсорной пленки, которую помещают в испытуемый образец и по изменению цвета полимерной сенсорной пленки определяют наличие в нем свинца(II), количество которого определяют по калиброванной цветовой шкале, предварительно полученной из не менее 5-ти испытуемых образцов с известными концентрациями свинца. Полимерную сенсорную пленку помещают в испытуемый образец анализируемого раствора известного объема от 0,5 мл до 10 мл вместе со смесью ацетата магния и уксусной кислоты, взятых в соотношении 2,50⋅10моль/л : 1,25⋅10моль/л анализируемого раствора, и выдерживают 2-18 минут. В качестве полимерной сенсорной пленки берут пластифицированную бис(этилгексиловым) эфиром себациновой кислоты (ДОС) поли(винилхлоридную) (ПВХ) пленку толщиной 2-7 мкм, содержащую индикатор нейтральный хромоионофор 9-диметиламино-5-[4-(15-бутил-1,13-диоксо-2,14-иоксанонадецил ...

ОПРЕДЕЛЕНИЕ ДИМЕДРОЛА

Изобретение относится к области аналитической химии, а именно к твердофазно-спектрофотометрическому определению фармацевтического препарата - димедрола. Способ включает использование в качестве цветореагента сульфоназо и фотометрирование, при этом проводят образование ионного ассоциата с азокрасителем сульфоназо в растворе, затем осуществляют его концентрирование на сорбенте-пенополиуретане с последующим фотометрированием ионного ассоциата непосредственно на твердой фазе при pH 8 и длине волны 538 нм. Достигается повышение чувствительности и селективности анализа. 1 пр., 2 табл., 3 ил.

СПОСОБ ОПРЕДЕЛЕНИЯ НЕСИММЕТРИЧНОГО ДИМЕТИЛГИДРАЗИНА В ПОЧВАХ И РАСТИТЕЛЬНЫХ МАТЕРИАЛАХ

Использование: аналитический контроль объектов окружающей среды на содержание соединений, обладающих токсичными свойствами. Сущность изобретения: способ заключается в обработке анализируемого вещества 0,5 - 1,5 мас.% раствором гидроксиламина солянокислого в воде, при массовом соотношении гидроксида натрия или калия к воде, равном 1:3-4,6 с последующим кипячением в токе инертного газа или воздуха, после чего конденсируют путем пропускания пара через 0,45 - 0,62%-ный раствор пара-нитробензальдегида в смеси уксусной кислоты и этиленгликоля при их объемном соотношении, равном 1:4-5. Предлагаемый способ позволяет значительно сократить время проведения анализа, повысить его точность и устранить дефицит исходного реагента. 2 табл.

СПОСОБ СОРБЦИОННО-СПЕКТРОСКОПИЧЕСКОГО ОПРЕДЕЛЕНИЯЗОЛОТА (III)

Изобретение относится к аналитической химии и может быть использовано для определения золота (III) во вторичном сырье и ломе, в природном сырье и технологических растворах. При проведении анализа сорбцию золота (III) осуществляют из солянокислых растворов ионообменником АВ-17 с предварительно закрепленным на нем в результате хемосорбции роданином, с последующим определением золота (III) в твердой фазе. Достигается повышение воспроизводимости и точности индивидуального определения золота (III) при экспрессных анализах за счет более полного извлечения золота из растворов в связи с увеличением сорбционной емкости. 1 табл.

БИОИНДИКАТОРНАЯ МЕДИЦИНСКАЯ МАСКА

Изобретение относится к медицинской технике, а именно к биоиндикаторной медицинской маске. Маска представляет собой фильтрующую поверхность из нетканого материала, имеющую складчатое строение, выполненное с возможностью увеличения площади фильтрующей поверхности при надевании на лицо. Маска имеет нанесенные на фильтрующую поверхность индикаторы, средства для крепления маски на лице, выполненные в виде эластичных ушных петель, и металлический фиксатор для прилегания к лицу. Нетканый материал представляет собой материал мельтблаун. В качестве индикатора использованы два реагента, нанесенные на граничащие между собой, но не пересекающиеся поверхности нетканого материала в области углов рта, имеющие разную по отношению друг к другу исходную цветность и выполненные с возможностью изменения исходной цветности по мере накопления патогенов в нетканом материале для сигнализирования о необходимости замены медицинской маски. Техническим результатом является создание одноразовой медицинской маски, ...

СПОСОБ ОПРЕДЕЛЕНИЯ ДИМЕТИЛДИОКСАНА В ВОЗДУХЕ

Способ определения диметилдиоксана в воздухе путем его концентрирования с помощью силикагеля, последующего элюирования растворителем, обработки аликвоты элюата раствором п-диметиламинобензальдегида и концентрированной серной кислотой и последующего фотометрирования, отличающийся тем, что в качестве растворителя для элюирования используют раствор аммиака, разбавленный дистиллированной водой в объемном соотношении аммиак: вода 3: 7, обработку аликвоты элюата раствором п-диметиламинобензальдегида и концентрированной серной кислотой проводят при температуре 90-100oС в течение 5 мин.

СПОСОБ ОБНАРУЖЕНИЯ АНАЛИЗИРУЕМОГО(ЫХ) ВЕЩЕСТВА(ВЕЩЕСТВ) ПРИ ПОМОЩИ КОЛЛОИДНЫХ МАГНИТНЫХ ЧАСТИЦ

... 1. Способ обнаружения и/или количественного определения, по меньшей мере, одного анализируемого вещества в жидкой среде, характеризующийся тем, что в нем используют магнитные коллоидные частицы, функционализированные по поверхности, по меньшей мере, одним специфическим лигандом подлежащего обнаружению и/или количественному определению анализируемого вещества, и тем, что он содержит следующие этапы: 1) соединение указанных частиц с указанной анализируемой средой; 2) воздействие на указанную среду магнитным полем, имеющим магнитную индукцию, достаточную для структурирования указанных магнитных частиц в виде цепочек; 3) поддержание воздействия этого магнитного поля в течение времени, достаточного для обеспечения связывания или взаимодействия рассматриваемого анализируемого вещества, по меньшей мере, с двумя специфическими лигандами, присутствующими соответственно на двух последовательных соседних частицах цепочки; 4) прекращение воздействия магнитным полем; и 5) определение присутствия и/или ...

СПОСОБ ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ КОБАЛЬТА

Предлагаемый способ позволяет определять малые количества кобальта в присутствии больших количеств никеля, вольфрама, молибдена и многих комплексообразователей: лимонной, винной, аскорбиновой, салициловой кислот, тиомочевины в сильнокислой среде. Определение проводят с органическим реагентом хинолин-азо Р в солянокислой среде (2 М раствор) без предварительного отделения основы, что способствует повышению избирательности, точности и экспрессности анализа.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ МЕЗАПАМА

Способ количественного определения мезапама путем обработки анализируемой пробы химическим реагентом, отличающийся тем, что в качестве химического реагента используют смесь 0,5 моль/л сульфата меди и 1 моль/л раствора салицилата натрия, взятых в объемных соотношениях 0,8-1,8: 1,0-2,2 мл, с последующей экстракцией полученного окрашенного соединения хлороформом и фотометрированием экстракта.

СПОСОБ ОПРЕДЕЛЕНИЯ СЕРОВОДОРОДА И МЕРКАПТАНОВ В УГЛЕВОДОРОДНЫХ ГАЗАХ ДЛЯ ПРОВЕДЕНИЯ ТЕХНОЛОГИЧЕСКОГО КОНТРОЛЯ

Изобретение относится к области аналитической химии и может быть использовано для проведения технологического контроля углеводородного газа, чтобы предотвратить коррозию трубопроводов. Способ включает отбор пробы, последовательную подачу ее в реакционную емкость с поглотительным раствором карбоната щелочного металла для выделения сероводорода и в реакционную емкость с поглотительным раствором щелочи в этиловом спирте для выделения меркаптанов, подачу в указанные емкости солянокислого раствора фотометрического реагента n-фенилендиамина с последующей подачей вспомогательного солянокислого раствора ионов железа (III), перемешиванием потоком воздуха с получением в каждой емкости однородного окрашенного раствора, раздельную подачу полученных растворов при нагревании до 35-40°С в фотометрический детектор, измерение сигналов пробы в фотометрическом детекторе и сравнение каждого из них с фоновым сигналом. Достигается упрощение, а также повышение безопасности и информативности анализа. 3 з.п. ф-лы ...

ТЕСТИРУЮЩАЯ ПОЛОСКА С РЕАГЕНТОМ ДЛЯ ОПРЕДЕЛЕНИЯ СОДЕРЖАНИЯ АНАЛИЗИРУЕМОГО ВЕЩЕСТВА

... 1. Тестирующая полоска с реагентом для применения при определении концентрации анализируемого вещества в физиологическом образце, включающая пористую матрицу, по меньшей мере один элемент системы, продуцирующей сигнал, основанный на окислении анализируемого вещества и по меньшей мере один гемолизирующий агент. 2. Тестирующая полоска по п.1, в которой указанная система, продуцирующая сигнал, включает фермент, который окисляет анализируемое вещество для продукции перекиси водорода. 3. Тестирующая полоска по п.2, в которой указанная система, продуцирующая сигнал, кроме того, включает фермент, который превращает по меньшей мере один субстрат в хромогенный продукт в присутствии перекиси водорода. 4. Тестирующая полоска по пп.1, 2 или 3, в которой указанное анализируемое вещество представляет собой глюкозу. 5. Тестирующая полоска по пп.1, 2 или 3, в которой указанный гемолизирующий агент присутствует в количестве, достаточном для продуцирования гемолиза, который эквивалентен концентрации гемолизата ...

СПОСОБ ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ ЭРБИЯ (III) В РАСТВОРАХ ЧИСТЫХ СОЛЕЙ

Изобретение относится к фотометрическому анализу применительно к определению содержания эрбия (III) в очень малой концентрации. Способ включает переведение эрбия (III) в комплексное соединение с ксиленоловым оранжевым в слабокислой среде. При этом к раствору эрбия (III) с рН 4-5 добавляют 180-250-кратное количество ксиленолового оранжевого. Также к раствору эрбия (III) добавляют 0,1-0,3 мл раствора поверхностно-активного вещества, полученного путем растворения 0,2 г желатина в теплой воде и доведения водой до 100 мл. Затем доводят объем растворов до 10 мл водой, нагревают на водяной бане при температуре 80-98°С в течение 10-15 минут. Техническим результатом изобретения является повышение чувствительности при фотометрическом определении эрбия (III).

Способ фотометрического определения железа (III) в растворах чистых солей в присутствии поверхностно-активного вещества

Изобретение относится к области аналитической химии, а именно к фотометрическому методу анализа, и может быть использовано для определения содержания железа (III) в растворах чистых солей, содержащих железо (III) в очень малой концентрации. Способ включает переведение железа (III) в комплексное соединение с органическим реагентом - ксиленоловым оранжевым и поверхностно-активным веществом в слабокислой среде, добавление дистиллированной воды до 10 мл объема с нагреванием на водяной бане при температуре 60-80°С и последующим фотометрированием полученного раствора после его охлаждения, при этом для построения градуировочного графика к 0,5 мл (0,8-2,0)⋅10М раствора железа (III) с рН, равным 4,0-5,0, создаваемым введением 3,0 мл ацетатного буферного раствора, добавляют 1,0 мл 1⋅10М раствора ксиленолового оранжевого и 0,2 мл 4⋅10М раствора поверхностно-активного вещества в виде этоксилата перфтороктилового спирта и дистиллированную воду до 10 мл, при этом нагревание на водяной бане осуществляют ...

СПОСОБ ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ ХРОМА (III) В РАСТВОРАХ ЧИСТЫХ СОЛЕЙ

Изобретение относится к области аналитической химии, а именно к фотометрическому методу анализа, и может быть использовано для определения содержания хрома (III) в растворах чистых солей, содержащих хром (III) в малой концентрации. В способе фотометрического определения хрома (III) в растворах чистых солей, включающем переведение его в комплексное соединение с ксиленоловым оранжевым в слабокислой среде, к раствору хрома (III) с pH 3,0-3,8 добавляют 200-кратное количество ксиленолового оранжевого и 200-кратное количество комплексона III и 0,1-0,2 мл раствора поверхностно-активного вещества. Поверхностно-активное вещество получают путем добавления к 0,2 г желатина воды до 100 мл. Затем доводят объемы растворов до 10 мл водой с последующим нагреванием на водяной бане при температуре 60-80°C в течение 15 мин. Изобретение позволяет повысить чувствительность при фотометрическом определении хрома (III). 1 ил., 4 пр.

СПОСОБ ФОТОМЕТРИЧЕСКОГО ОПРЕДЕЛЕНИЯ ХИМИЧЕСКИХ ЗАГРЯЗНИТЕЛЕЙ ВОДЫ

Изобретение относится к аналитической химии и может быть использовано для автоматизации контроля химических загрязнителей в воде. Способ предусматривает использование бумажной ленты из натуральных и химических волокон, модифицированной сорбирующими составами, пропускание через ленту пробы воды, добавление аналитического реагента с последующим фотометрированием, что позволяет определять широкую номенклатуру химических загрязнителей в автоматическом режиме.

СПОСОБ ОПРЕДЕЛЕНИЯ ГИДРОХИНОНА И ДИОКСИМПАРАХИНОНА В РАСТВОРАХ

Изобретение относится к области аналитической химии, а именно к способу определения гидрохинона и диоксимпарахинона в растворах. В изобретении описан способ определения гидрохинона и диоксимпарахинона в растворах путем обработки пробы гидроксидом и ацетатом натрия с последующим фотометрированием окрашенных растворов.

СПОСОБ ОПРЕДЕЛЕНИЯ 2,4-ДИХЛОРФЕНОЛА В ВОДНЫХ РАСТВОРАХ

Изобретение относится к аналитической химии органических соединений и может быть использовано для контроля за содержанием 2,4-дихлорфенола в хлорированных сточных водах производства красителей, пестицидов, пластификаторов. Определенный объем анализируемого водного раствора обрабатывают сульфатом лития, метилэтилкетоном и экстрагируют в течение 15 мин. После расслаивания фаз отделяют концентрат, добавляют фотометрические реагенты и фотометрируют. Содержание 2,4-дихлорфенола находят по градуировочному графику. Применяемый экстрагент позволяет увеличить полноту извлечения 2,4-дихлорфенола при 50-кратном концентрировании до 98%, повысить коэффициент распределения до 3800, снизить предел обнаружения на порядок и улучшить условия труда путем замены растворителей менее токсичными экстрагентами.

Способ количественного определения гексаметилендималеинимида

Способ количественного определения гекоаметидендималеинимида путем обработки раствора пробы в концентрированной азотной кислоте реагентами о последующим измерением оптической плотности подученного раствора при 400 нм, отличающийся тем, что в качестве реагентов используют раствор смеси концентрированных азотной и уксусной кислот 1:1 (раствор I) и 18-22%-ный водный раствор гидроксида натрия (раствор II), и обработку раствора пробы ведут при температуре 20-25°С сначала раствором I в течении 30 мин, а затем раствором II.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ СУММЫ АМИНОКИСЛОТ В ТРУТНЕВОМ МОЛОЧКЕ

Изобретение относится к области аналитической химии, а именно к способам количественного анализа, и может быть применено в практике контрольно-аналитической службы ПО "Фармация". Цель изобретения - повышение чувствительности способа. Способ заключается в обработке анализируемой пробы аллоксаном в среде диметилацетамида при температуре кипящей водяной бани с дальнейшим добавлением к окрашенному продукту солей Са2+ и последующим фотометрированием полученного раствора. Отличительными признаками способа является применение аллоксана в качестве цветореагента и солей Ca2+, деметилацетамида как растворителя. Открываемый минимум в сумме аминокислот 0,55 мкг/мл.

СПОСОБ ОПРЕДЕЛЕНИЯ ИЗОПРОПИЛНИТРАТА В СТОЧНОЙ ВОДЕ

Изобретение относится к аналитической химии, а именно - к способам количественного определения изопропилнитрата в сточной воде рабочей зоны предприятий химической промышленности и других областях техники. Изобретение направлено на сокращение времени проведения способа. Поставленная задача достигается тем, что в способе, включающем взятие пробы, обработку ее цветореагентом и последующее определение концентрации изопропилнитрата фотометрированием, в качестве цветореагента используют водный раствор смеси салициловой кислоты и салицилата натрия, взятых в массовом отношении 1:(10-11), после обработки цветореагентом пробу выпаривают досуха, растворяют остаток в концентрированной серной кислоте, добавляют воду и раствор аммиака и фотометрированию подвергают полученный раствор.

СПОСОБ ОПРЕДЕЛЕНИЯ ИЗОПРОПИЛНИТРАТА В ВОЗДУХЕ

Изобретение относится к аналитической химии, а именно - к способам количественного определения изопропилнитрата в воздухе. Изобретение решает задачу сокращения времени определения. Поставленная задача достигается в способе определения изопропилнитрата в воздухе путем контакта индикатора с анализируемой пробой с последующим определением изопропилнитрата, при этом в качестве индикатора используют хемосенсоры на основе оксида слова и определение концентрации ведут по изменению величины напряжения на индикаторе.

ОПРЕДЕЛЕНИЕ ДИМЕДРОЛА ИЛИ ПАПАВЕРИНА

Определение димедрола и папаверина, включающее экстракцию анализируемой пробы кислотным азокрасителем и фотометрование полученного ионного ассоциата, отличающееся тем, что в качестве цветореагента используют сульфоназо, а фотометрируют экстракт бутанолом при рН 4 и 5 соответственно в области поглощения с максимумом при 580 нм.

КОМПОЗИЦИИ СТАБИЛИЗИРОВАННОГО ТЕТРАЗОЛИЙ-ФЕНАЗИНОВОГО РЕАГЕНТА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

... 1. Композиция реагентов, содержащая тетразолиевый краситель, феназиновый агент переноса электронов, и эффективное количество соединения группы IIIA и/или флавинового стабилизирующего агента. 2. Композиция по п.1, в которой указанный флавиновый стабилизирующий агент представляет собой FAD. 3. Композиция по п.1 или 2, в которой указанный стабилизирующий агент группы IIIA представляет собой борат или борную кислоту. 4. Композиция по пп.1, 2 или 3, в которой указанная композиция реагентов содержит аналитическую систему, продуцирующую сигнал окисления. 5. Композиция по любому из пп.1-4, где указанная композиция представляет собой жидкую композицию. 6. Композиция по любому из пп.1-4, где указанная композиция представляет собой сухую композицию. 7. Реакционноспособная индикаторная полоска, содержащая субстрат, и композицию реагентов по любому из пп.1-6. 8. Аналитическая система обнаружения или измерения, включающая (А) реакционноспособную индикаторную полоску по п.7, и (В) автоматизированный прибор ...

СПОСОБ КАЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ ПРОИЗВОДНЫХ ГУАНИДИНА

Способ качественного определения производных гуанидина путем обработки анализируемой пробы цветным реактивом в присутствии серной кислоты с образованием окрашенного продукта, отличающийся тем, что перед обработкой цветным реактивом анализируемую пробу обрабатывают последовательно избытком нитрита натрия и сульфаминовой кислотой до полного прекращения выделения пузырьков газа, при этом избыток нитрита натрия по отношению к анализируемой пробе составляет не менее 1000 мольный, избыток сульфаминовой кислоты по отношению к нитриту натрия составляет 1,3-1,5 мольный, а концентрация серной кислоты в конечном объеме реакционной смеси составляет 20-30 мас.%.

СПОСОБ ИДЕНТИФИКАЦИИ РАКЕТНЫХ ГОРЮЧИХ

Способ идентификации ракетных горючих, включающий отбор анализируемой пробы, внесение индикатора, их смешивание, с последующим определением марки горючего, отличающийся тем, что перед внесением индикатора добавляют водный раствор гидроксида натрия в анализируемую пробу, в качестве индикатора используют бихромат аммония, а марку аминного горючего определяют по ярко-желтой окраске, гидразинового горючего по темно-коричневой окраске.

СПОСОБ ЭКСПРЕСС-ОБНАРУЖЕНИЯ ВЕЩЕСТВ НА ТВЕРДЫХ ПОВЕРХНОСТЯХ

... 1. Способ экспресс-обнаружения веществ на твердых поверхностях, включающий нанесение по крайней мере одного реагента на исследуемую поверхность с помощью аэрозольной упаковки и визуальный контроль за изменением окраски поверхности, отличающийся тем, что в качестве первого реагента используют раствор диоксинсантенового красителя в полярном органическом растворителе при рН 1-3, а в качестве второго реагента водный раствор уксусной кислоты. 2. Способ экспресс-обнаружения веществ на твердых поверхностях по п.1, отличающийся тем, что в качестве раствора диоксинсантенового красителя в полярном органическом растворителе используют смесь 0,3-0,6 мас.% раствора эозина или флоксина в ацетоне и 0,75 мас.% водного раствора хлористого водорода в соотношении 70:1. 3. Способ экспресс-обнаружения веществ на твердых поверхностях по п.1, отличающийся тем, что после нанесения первого реагента на исследуемую поверхность с помощью аэрозольной упаковки на поверхность наносят 3-5 мас.% раствор уксусной кислоты ...

СПОСОБЫ И УСТРОЙСТВА ДЛЯ ИСПОЛЬЗОВАНИЯ ПРИ АНАЛИЗАХ ПО ОПРЕДЕЛЕНИЮ КОНЦЕНТРАЦИИ АНАЛИЗИРУЕМОГО ВЕЩЕСТВА

... 1. Способ определения концентрации анализируемого вещества в пробе, содержащий этапы: использование системы, содержащей реагентную индикаторную полоску, имеющую область для приема пробы, и измеритель для определения концентрации анализируемого вещества в пробе, введенной в указанную область для приема пробы, введение пробы в указанную область для приема пробы, при этом пробу выбирают из группы, состоящей из контрольном жидкости и исследуемой жидкости, при условии, что контрольная жидкость свободна от компонента, замедляющего растворение медиатора, и окислителя, когда концентрацию анализируемого вещества определяют с использованием электрохимических способов, и определение измерителем концентрации анализируемого вещества в пробе, при котором указанный способ дополнительно содержит этап определения того, является ли проба контрольной жидкостью или исследуемой жидкостью, для получения информации по идентификации пробы. 2. Способ по п.1, при котором пробу определяют как контрольная жидкость ...

СПОСОБ ОПРЕДЕЛЕНИЯ ЖЕЛЕЗА В ВОДЕ

Способ определения железа в воде, включающий обработку воды хлороформом, отличающийся тем, что определяют общее содержание железа в пробе воды, а затем в другой пробе воды создают рН в пределах 4,0-5,0, добавляют хлороформ до получения соотношения хлороформ - вода не менее 1:5, интенсивно перемешивают, отстаивают до разделения пробы на три слоя: воду, пленку, содержащую железо-органический комплекс, и хлороформ, в воде верхнего слоя определяют содержание железа, после чего по разнице содержания железа в первой пробе и верхнем слое воды второй пробы определяют содержание железа, связанного в железо-органические комплексы.

СПОСОБ ЭКСПРЕСС-ОБНАРУЖЕНИЯ КАННАБИСА

... 1. Способ экспресс-обнаружения каннабиса, включающий последовательную обработку исследуемого образца компонентами комплексного реактива, при этом в качестве первого компонента для обработки пробы образца берут диазосоединение в виде раствора в хлористом метилене, а в качестве второго для повторной обработки берут щелочной реагент, о наличии искомого вещества в пробе судят по изменению окраски исследуемого образца, отличающийся тем, что в качестве второго компонента для повторной обработки исследуемого образца берут 2,0-5,0% раствор моноэтиламина в изопропаноле в диапазоне pH 8,5-9,5, после чего взаимодействие компонентов реактива вызывает поддающуюся обнаружению окраску, по которой судят о наличии искомого вещества в пробе. 2. Способ по п.1, отличающийся тем, что в качестве второго компонента берут 2,0-5,0% раствор моноэтиламина в изопропаноле.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ КЛОФЕЛИНА

Изобретение относится к области аналитической химии, а именно к способам количественного определения лекарственных препаратов. Целью изобретения является разработка способа количественного определения клофелина, позволяющего провести оценку однородности дозирования клофелина в таблетках. Способ заключается в том, что дезинтеграцию таблетки проводят в буферном растворе рН 3,3 ± 0,2 в присутствии бромфенолового синего. Полученный ионный ассоциат экстрагируют хлороформом, фильтруют через безводный сульфат натрия и фотометрируют. Параллельно в тех же условиях проводят определение со стандартным раствором клофелина. Содержание препарата в одной таблетке находят по формуле. Cпособ количественного определения клофелина в одной таблетке обладает высокой чувствительностью, достаточной точностью, экономичен, прост в исполнении, не требует сложной аппаратуры и может быть рекомендован для использования в работе контрольно-аналитических лабораторий химико-фармацевтических заводов и производственных ...

СПОСОБ ОПРЕДЕЛЕНИЯ АРОМАТИЧЕСКИХ ГИДРОКСИПРОИЗВОДНЫХ

Изобретение относится к аналитической химии (фотометрического анализа) и может быть использовано для фотометрического определения ароматических гидроксипроизводных в природных и сточных водах. Способ включает обработку анализируемого раствора при рН от 9 до 12 тетрафтороборатом 4-нитрофенилдиазония до концентрации 0,01 - 0,03 М, катионными поверхностно-активными веществами до концентрации 8•10- 2•10М, сорбцию образовавшегося окрашенного азосоединения на пенополиуретане и измерение диффузного отражения.

СПОСОБ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ КЕТАМИНА ГИДРОХЛОРИДА В ЛЕКАРСТВЕННЫХ КОМПОЗИЦИЯХ, СОДЕРЖАЩИХ БЕНЗЭТОНИЯ ХЛОРИД

Изобретение относится к аналитической химии, в частности к способам количественного определения кетамина гидрохлорида в лекарственных композициях, содержащих бензэтония хлорид. Определение ведут обработкой пробы водно-этанольной смесью до концентрации 0,00015-0,0015 г/мл, взятием двух аликвот, одну из которых обрабатывают щелочью до pH 11, другую - таким же объемом кислоты до pH 2, с последующим измерением оптической плотности одного полученного раствора относительно другого при длинах волн 269, 273, 276 и 304 нм и расчетом содержания кетамина гидрохлорида. Способ позволяет определять кетамин гидрохлорид в присутствии бензэтония хлорида в течение 45 мин с чувствительностью определения при длине волны 269,5 нм 0,00007 г/мл, при 273,5-0,00012, при 276,5-0,00007 и при 304-0,00028 против 0, 00004 г/мл при снижении трудоемкости анализа и улучшении метрологических характеристик (за счет исключения систематических ошибок).

ФОТОКОЛОРИМЕТРИЧЕСКИЙ ГАЗОАНАЛИЗАТОР

Изобретение относится к газовому анализу, а именно к аналитическим приборам. Газоанализатор содержит блок фотометрирования с приемником и источником излучения, установленную между ними перегородку с щелью и индикаторной трубкой, размещенной вдоль щели, ширина которой составляет не более 0,4 диаметра индикаторной трубки, устройство подачи газов и вторичные приборы, связанные с приемником излучения. Использование в газоанализаторе индикаторной трубки, взаимодействующей с источником и приемником излучения, и размещение ее в перегородке вдоль щели с определенной шириной, позволили расширить номенклатуру компонентов в анализируемом газе.

ФОТОКОЛОРИМЕТРИЧЕСКИЙ ГАЗОАНАЛИЗАТОР

Фотоколориметрический газоанализатор, содержащий реакционную камеру с индикаторной лентой, источник излучения, дифференциально включенные рабочий и сравнительный фотоприемники, командоаппарат, выход которого подсоединен к селектору импульсов и лентопротяжному механизму, отличающийся тем, что, с целью повышения точности, чувствительности, надежности и помехоустойчивости, он дополнительно содержит генератор прямоугольных импульсов со скважностью Q ≫ 1, два амплитудных детектора положительных и отрицательных сигналов с управляемым сбросом сигналов, сумматор, управляемый ключ, счетчик импульсов, схему задержки и схему ИЛИ, при этом выход генератора импульсов соединен с источником излучения и входом счетчика импульсов, выходы которого соединены с управляющим входом ключа и через схему задержки с одним из входов схемы ИЛИ, второй вход которой соединен с выходом командоаппарата, информационные входы амплитудных детекторов подсоединены к точке соединения выходных цепей фотоприемников, выходы амплитудных ...

УЛУЧШЕННЫЙ СПОСОБ ОПРЕДЕЛЕНИЯ КОНЦЕНТРАЦИИ АНАЛИТА В ФИЗИОЛОГИЧЕСКОЙ ЖИДКОСТИ

ПЕРЕДАЮЩИЕ СИГНАЛ АПТАМЕРЫ, КОТОРЫЕ ПРЕОБРАЗУЮТ СИГНАЛ РАСПОЗНАВАНИЯ МОЛЕКУЛЫ В ДИФФЕРЕНЦИАЛЬНОЙ СИГНАЛ

... 1. Способ преобразования конформационного изменения, передающего сигнал аптамера после его связывания с лигандом, в дифференциальный сигнал, генерированный репортерной молекулой, причем указанный способ включает стадии контактирования передающего сигнал аптамера с лигандом, где указанный передающий сигнал аптамер связывается с указанным лигандом, и детекции дифференциального сигнала, генерированного репортерной молекулой в результате конформационного изменения передающего сигнал аптамера, который после связывания с лигандом передает сигнал о конформационном изменении. 2. Способ по п.1, где указанный дифференциальный сигнал является оптическим сигналом, электрохимическим сигналом или ферментативным сигналом. 3. Способ по п.2, где указанный оптический сигнал выбран из группы, состоящей из флуоресценции, колориметрической интенсивности, анизотропии, поляризации, времени жизни, длины волны излучения и длины волны возбуждения. 4. Способ по п.1, где указанный передающий сигнал аптамер содержит ...

ФОТОМЕТРИЧЕСКИЙ СПОСОБ ОПРЕДЕЛЕНИЯ ХРОМА В СПЛАВАХ

Изобретение относится к области аналитической химии и позволяет с высокой чувствительностью и точностью определять микро- и макросодержания элементов. Сущность предлагаемого способа в том, что в качестве органического реагента для фотометрического опр деления хрома используют новосинтезированный реагент 2,7-бисазопроизводных хромотроповой кислоты, при этом определение ведут в слабокислой среде рH 3oC6 и при светопоглощении λ = 750 нм..

ОБРАЗОВАНИЕ МУЛЬТИПЛЕКСОВ НУКЛЕИНОВЫХ КИСЛОТ

... 1. Способ создания мультиплекса нуклеиновых кислот, включающий стадии: 1) создания смеси, содержащей воду, дуплекс Уотсона-Крика, достаточное число одноцепочечных молекул с последовательностью смешанных оснований для образования мультиплекса, который включает в себя дуплекс Уотсона-Крика, и акселераторный (катализирующий) агент, который увеличивает скорость или количество образования мультиплекса, причем указанный мультиплекс является триплексом или квадруплексом, где указанные одноцепочечные молекула или молекулы выбраны таким образом, что при нахождении в мультиплексе каждая из них является связанной со всеми другими цепями этого мультиплекса прикреплением по правилам спаривания оснований, причем эти правила являются либо правилами спаривания оснований Уотсона-Крика, либо правилами спаривания оснований гомологичного связывания; и 2) инкубирования указанной смеси для образования этого мультиплекса, причем каждая цепь указанного мультиплекса связана со всеми другими цепями этого мультиплекса ...

СПОСОБ И СОСТАВ ДЛЯ ОБНАРУЖЕНИЯ СЛЕДОВ КРОВИ

... 1. Состав для обнаружения следов крови человека или животного, содержащий соединение люминола, окислитель и щелочь, растворенные в предпочтительно водном растворителе, отличающийся тем, что: - соединение люминола присутствует в количестве, соответствующем концентрации от 1 до 20 ммоль/л в конечном составе, - в качестве окислителя использована перекись водорода, которая присутствует в концентрации от 25 до 100 ммоль/л в конечном составе, - в качестве щелочи использована сода NaOH, которая присутствует в концентрации от 25 ммоль/л до 500 ммоль/л в конечном составе. 2. Состав по п.1, отличающийся тем, что соединение люминола выбрано из группы, содержащей люминол, диэтилизолюминол и аминобутилэтилизолюминол. 3. Состав по п.1, отличающийся тем, что сода NaOH присутствует в концентрации от 25 до 150 ммоль/л или приблизительно 90 ммоль/л в конечном составе. 4. Состав по п.2, отличающийся тем, что сода NaOH присутствует в концентрации от 25 до 150 ммоль/л или приблизительно 90 ммоль/л в конечном ...

СПОСОБ ОПРЕДЕЛЕНИЯ КОНЦЕНТРАЦИИ АНАЛИТА В ФИЗИОЛОГИЧЕСКОЙ ЖИДКОСТИ И МОБИЛЬНОЕ УСТРОЙСТВО, СКОНФИГУРИРОВАННОЕ ДЛЯ ОПРЕДЕЛЕНИЯ КОНЦЕНТРАЦИИ АНАЛИТА В ФИЗИОЛОГИЧЕСКОЙ ЖИДКОСТИ

Изобретение относится к способу определения концентрации аналита в физиологической жидкости и набору для определения концентрации аналита в физиологической жидкости, при этом набор содержит мобильное устройство, имеющее камеру и процессор, и оптическую тест-полоску с тестовым полем. Способ определения концентрации аналита в физиологической жидкости путем использования мобильного устройства, имеющего камеру, включает а) захват ряда калибровочных изображений по меньшей мере одной интересующей области объекта путем использования камеры, причем калибровочные изображения отличаются по своей яркости; б) получение из каждого калибровочного изображения из ряда, полученного на шаге а), по меньшей мере одного основного калибровочного числа, характерного для функции тонального отображения мобильного устройства; в) определение по меньшей мере одной вероятной функции тонального отображения мобильного устройства с учетом основных калибровочных чисел из калибровочных изображений из ряда, полученного на ...

СПОСОБ ОПРЕДЕЛЕНИЯ СУЛЬФИД-ИОНОВ В ВОДНЫХ РАСТВОРАХ

Изобретение относится к аналитической химии и может быть использовано при фотометрическом определении сульфид-ионов в водных растворах. Способ определения сульфид-ионов в водных растворах заключается в приготовлении реагента, проведении фотометрической реакции анализируемого раствора с реагентом, определении оптической плотности реакционной смеси и расчете концентрации сульфид-ионов. В качестве цветореагента используют раствор нитрата серебра. В качестве стабилизатора образующегося сульфида серебра применяют раствор силиката натрия. Обеспечивается экспрессный фотометрический метод, в котором реакция проходит в момент смешения реагентов с анализируемым раствором без нагревания. 1 ил., 2 табл., 9 пр.

Способ определения меркаптанов в газовой смеси

Способ определения трихлорэтилена в сточных водах

Способ определения веществ каменноугольного пека,нерастворимых в хинолине

Способ определения @ -нафталинсульфокислоты в сульфомассе

Способ определения новокаина

Способ определения полиэтиленполиаминов

Сущность изобретения: анализируемую пробу обрабатывают солью железа (III) и 5-сульфосалициловым альдегидом в присутствии ацетата металла, измеряют оптическую плотность, вводят реагент, разрушающий окрашенный комплекс при молярном соотношении железа (III) и реагента 1 (1-10), и повторно измеряют оптическую плотность раствора. 1 з.п. ф-лы, 5табл.

Способ раздельного определения первичных и вторичных гидроксильных групп ацилоксипроизводных спиртов

Способ определения паров ацетона в воздухе

Способ определения кодеина в лекарственных смесях

Изобретение относится к аналитической химии, в частности к способу определения кодеина в лекарственных смесях. Целью изобретения является повышение селективности способа. Способ осуществляют растворением анализируемой пробы в 60-65%-ном водном этаноле. Кодеин вьщеляют из раствора тонкослойной хроматографией на кислом оксиде алюминия. Элюирова- ние проводят смесью зфира и этанола, взятых в объемном соотношении 80-85: : 10-15. Зону кодеина проявляют в парах йода, злюируют зту зону 0,05- 0,1 н. раствором соляной кислоты и фотометрируют полученный раствор. Селективность способа обеспечивается полным отделением кодеина от сопутствующих компонентов. i (Л ...

Способ качественного определения кумаринов,содержащих углерод-углеродную двойную связь в боковой цепи

Изобретение касается аналити- Iческой химии, в частности качественного определения кумаринов (КОК), содержащих углерод-углеродную двойную связь в боковой цепи. С целью повьшения специфичности и чувствительности КОК пробу растворяют в смеси спирта и диметилформамида в объемном соотношении 1-8:7-1, добавляют 10%-ный раствор едкого натра и5%-ный раствор перманганата калия. Затем нагревают до образования осадка оксида марганца. В фильтрат добавляют 1-2 капли нитрата кобальта до образова- ,ния аморфного осадка зеленого цвета. Чувствительность КОК 0,0008 г/мл. 3 табл. (Л ...

Способ количественного определения эфирного масла в цветках розы

Способ количественного определения резорцина в воде

Изобретение относится к аналитической химии и прикладной биохимии, а именно к способам определения резорцина в воде. Цель изобретения - повышение чувствительности , упрощение и ускорение процесса . Для этого к анализируемой пробе добавляют фосфатный буфер с рН 7,8 - 8,0, водные растворы пирокатехина (15 - 30 мМоль/л), пероксидазы и пероксида водорода (100 - 180 мМоль/л). Смесь быстро перемешивают и измеряют ее оптическую плотность через определенные промежутки времени в течение 2-3 мин при 680 - 710 нм. По рассчитываемому отношению изменения оптической плотности во времени судят о концентрации резорцина в пробе. 1 з.п.ф-лы, 1 табл. СО С ...

Способ определения полисахаридов в препаратах, выделенных из растений

Изобретение относится к аналитической химии органических соединений и может быть использовано для определения водорастворимых полисахаридов. Предложенный способ позволяет сократить продолжительность определения с 72 ч до 4 мин, и упростить его (исключается необходимость темного помещения). Это достигается обработкой препарата, выделенного из мать-и-мачехи или подорожника , йодмонохлоридом, растворен ным в соляной кислоте, при рН 2-3 в течение 2-3 мин. 1 табл.

Биочип для мультиплексного анализа

Предлагаемая полезная модель относится к области медицины, а именно к диагностике, и может быть использована для диагностики онкологических заболеваний. Биочип для мультиплексного анализа содержит прозрачную подложку из стекла, разделенную на функциональную и рабочую части, функциональная часть служит для фиксации биочипа в руках, рабочая часть имеет покрытие и разделена на тестовые ячейки посредством решетки из пластика, каждая тестовая ячейка снабжена иммобилизованными флуоресцентными антителами, специфичными к антигенам клеток, биочип содержит пленку, закрепленную поверх решетки, на подложку рабочей части нанесено покрытие, создающее положительный заряд на поверхности стекла, в тестовые ячейки внесены антитела, конъюгированные с флуоресцентной меткой Су-3, и реагент, препятствующий высыханию внесенных антител, рабочая поверхность биочипа покрыта воздухонепроницаемой стерильной пленкой, функциональная часть биочипа снабжена информацией о локализации внесенных антител. Технический результат от использования предлагаемого биочипа заключается в обеспечении возможности анализа клеток геморрагической жидкости, клеток мочи, клеток из материала тонкоигольной аспирационной биопсии и клеток, полученных из соскобов резецированной солидной опухоли, повышении надежности работы биочипа и увеличении срок его годности. 4 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 197 681 U1 (51) МПК G01N 21/78 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 21/78 (2019.08) (21)(22) Заявка: 2019115153, 27.04.2018 (24) Дата начала отсчета срока действия патента: Дата регистрации: 21.05.2020 Адрес для переписки: 603106, г. Нижний Новгород, а/я 15, ООО Патентно-правовая фирма "Петухов и Партнеры" (56) Список документов, цитированных в отчете о поиске: RU 142470 U1, 17.06.2014. RU 137188 U1, 10.02.2014. WO 2009/112594 A2, 17.09.2009. RU 2303634 C2, 27.07.2007. Стр.: 1 U 1 1 9 7 6 8 1 R U антитела, конъюгированные с флуоресцентной ...

Retroreflectors for remote detection

A detection system includes a retroreflector and a layer of material over the retroreflector, the material being subject to change in transmission with respect to an optical property of radiation, e.g. wavelength or polarization, with exposure to a phenomenon. The retroreflector and layer are illuminated from a radiation source of multiple aspects of the optical property. A sensor senses radiation retroreflected back through the layer. The retroreflector may, for example, be an array of or individual prisms or an array of or individual cat's eye microspheres. The layer of material above the retroreflector can include a colorimetric dye. In an embodiment, the retroreflector and layer are on the surface of a carrier that moves through a medium, e.g. a projectile or vehicle moving through the air. In a method of detecting a phenomenon, retroreflective elements are distributed in an array, as in the atmosphere or across a region of ground.

Drug detection method and apparatus

A drug detection apparatus for identifying whether a gas sample contains an acidic gas includes a reactor having a gas inlet, a detection reagent containing an oxidant and a reductant, and a catalyst triggering a chemical adsorption with the oxidant and the reductant. A drug detection method applied to a drug detection apparatus is also disclosed. The drug detection apparatus and method can detect the acidic gases from drugs immediately, sensitively and selectively, thereby improving the efficiency of suspect inspection of drug smuggling in airports.

Carbon monoxie (co) microsir sensor system

A very small low cost apparatus and method are provided for determining concentration from a target gas by means optically monitoring one or more sensors that respond to carbon monoxide. The apparatus comprises a photon source optically coupled to the sensor and the photon intensity passing through the sensor is quantified by one or more photodiode(s) in a system, so that the photon flux is a function of at least one sensor's response to the target gas, e.g., transmits light through the sensor to the photodiode. The photocurrent from the photodiode is converted to a sensor reading value proportional to the optical characteristics of the sensors and is loaded into a microprocessor or other logic circuit. In the microprocessor, the sensor readings may be differentiated to determine the rate of change of the sensor readings and the total photons absorbed value may be used to calculate the CO concentration.

Analytical devices for detection of low-quality pharmaceuticals

An analytical device, in particular, a paper analytical device (PAD), for detection of at least two chemical components indicative of a low quality pharmaceutical product is provided. The analytical device can include a porous, hydrophilic medium, at least two assay regions associated with the porous, hydrophilic medium, at least one assay reagent or precursor thereof in the assay regions, and at least one electronically readable information zone.

Method and apparatus for inspecting biological samples

A method of selecting for analysis a sample of a biological material anisotropically distributed on a substrate is disclosed, comprising the steps of directing a beam of radiation onto the substrate, said radiation being selected to interact with the biological material to an extent corresponding to the anisotropy; measuring the interaction at plurality of locations; and selecting the sample by reference to the measurements. An inspection apparatus for selecting for analysis a sample of a biological material anisotropically distributed on a substrate is disclosed comprising a source of radiation selected to interact with the anisotropically distributed biological material to an extent corresponding to the anisotropy; a detector for measuring the interaction at plurality of locations on the substrate; and a processor coupled to the detector for utilizing the measurement to select a portion of the sample for further analysis.

URINE ANALYSIS METHOD, DEVICE THEREOF, PROGRAM USED IN URINE ANALYSIS METHOD, AND STORAGE MEDIUM THEREOF

An analysis device includes determination means, capable of performing a first determination on whether a specific component in urine is positive or negative, on the basis of a color reaction between a reagent and the specific component in urine; and optical measurement means capable of working out data on light absorption characteristics of the urine itself with respect to light of a predefined wavelength region. When the data on the light absorption characteristics lies within a predefined range, and a result of the first determination is either positive or negative as established beforehand, the determination means changes the result of the first determination to a false positive or a false negative, or performs second determination to the effect that there is a likelihood of a false positive or a false negative. 1. A urine analysis method , comprising:a first determination step of, on the basis of a color reaction between a reagent and a specific component in urine, determining a distinction between a positivity and negativity of the specific component; anda step of working out data on light absorption characteristics of the urine itself with respect to tight of a predefined wavelength region,this method further comprising:a second determination step of, when a value of the data on the light absorption characteristics lies within a predefined range and a determination result in the first determination step is either positive or negative as established beforehand, changing the determination result to a false positive or false negative, or determining that there is a likelihood of a false positive or a false negative.2. The urine analysis method according to claim 1 ,wherein in the second determination step the value of the data on the light absorption characteristics is determined to lie within the predefined range when the urine is of a predefined colorless grade or yellow grade.3. The urine analysis method according to claim 1 , whereinthe specific component in ...

QUANTITATIVE MICROFLUIDIC DEVICES

Described herein are disposable paper-based assay devices for detection and quantitation of analytes in liquid clinical samples, e.g., blood or urine. The devices may be particularly suitable for use in regions of the world where health care infrastructure is absent. The test devices are versatile in that they can be adapted to detect a variety of analytes. The devices are also easy to use and interpret. Typically, all that is needed to conduct an assay is to apply a drop of sample to the indicated location on the device. The devices are typically colorimetric and readable with the naked eye. 1. A test device for quantitative determination of an analyte in a liquid biological sample , the device comprising a liquid sample input;', 'a colorimetric test readout;', 'a negative control that upon absorption of the sample maintains or displays a predetermined color;', 'a positive control, and', 'a liquid flow path which, responsive to application of a liquid sample to said input, transports liquid between said input and said readout and controls;, 'a porous, hydrophilic sheet defining plural functional regions includingdisposed in said device, at least one dried, color-producing reagent arranged to produce a shade or pattern of color in a said readout as a function of the concentration of an analyte in the sample; anddisposed in said device, a dried, color-producing reagent which reacts at said positive control to produce color;wherein a valid test is indicated by color change in said positive control and maintenance or display of a predetermined color at said negative control.2. A test device for quantitative determination of an analyte in a liquid biological sample , the device comprising a liquid sample input;', 'a colorimetric test readout including a region of a color backing said readout which optically interacts with color developed at said readout to improve visual discrimination among different analyte concentrations in an applied sample;', 'a colorimetric ...

Solid and Liquid Textile-Treating Compositions

Provided herein are solid textile treating compositions; compositions containing colorants stabilized with one or more colorant stabilizers; compositions containing colorants that do not need to be stabilized by one or more colorant stabilizers; solid wash cycle conditioning agents; liquid textile treating compositions; cleaning agent compositions containing these; methods of making these; methods of treating textiles with these; textiles treated by these; containers containing the compositions; and methods of visually designating when a composition has reached or passed its pull date. 1. A solid textile-treating composition , comprising:(a) a water-soluble core comprising a water-soluble carrier; (i) a water-soluble polymer;', '(ii) a colorant; and', '(iii) a colorant stabilizer; and, '(b) a coating that at least partially covers the water-soluble core, the coating comprising'}(c) a flow aid physically associated with the coating such that the flow aid is partially or fully exposed on an outer surface of the coating.2. The solid textile-treating composition of claim 1 , wherein the coating further comprises a perfume.3. (canceled)4. The solid textile-treating composition of claim 2 , wherein at least some of the perfume is encapsulated.5. The solid textile-treating composition of claim 4 , wherein at least some of the encapsulated perfume is encapsulated in a microcapsule.6. (canceled)7. (canceled)8. The solid textile-treating composition of claim 1 , wherein the coating does not comprise a perfume.9. (canceled)10. The solid textile-treating composition of claim 1 , wherein the flow aid comprises a fabric softener.11. The solid textile-treating composition of claim 10 , wherein the fabric softener is a polysiloxane claim 10 , a textile-softening clay claim 10 , a cationic polymer claim 10 , or any combination thereof.1217-. (canceled)18. The solid textile-treating composition of claim 1 , further comprising a bleaching agent claim 1 , a bleach activator claim 1 , ...

IN VITRO POINT-OF-CARE SENSOR AND METHOD OF USE

An in vitro sensor for point-of-care detection of at least one analyte or reaction product includes an inert, impermeable substrate, a sensing system, and a reference system. The substrate includes a first transparent surface oppositely disposed from a second surface and first and second cavities. Each of the first and second cavities defines an opening at the second surface. The sensing system is disposed in at least a portion of the first cavity and includes an analyte-detection optode membrane, an analyte-permeable membrane, and a plurality of non-transparent microbeads associated with at least one of the analyte-detection optode membrane and the analyte-permeable membrane. The analyte-permeable membrane is layered upon the analyte-detection optode membrane and covers the opening of the first cavity. The reference system is disposed in at least a portion of the second cavity. 1. An in vitro sensor for point-of-care (POC) detection of at least one analyte or reaction product , said sensor comprising:an inert, impermeable substrate including a first transparent surface oppositely disposed from a second surface and first and second cavities, each of said first and second cavities defining an opening at said second surface;a sensing system disposed in at least a portion of said first cavity, said sensing system comprising an analyte-detection optode membrane, an analyte-permeable membrane, and a plurality of non-transparent microbeads associated with at least one of said analyte-detection optode membrane and said analyte-permeable membrane, said analyte-permeable membrane being layered upon said analyte-detection optode membrane and covering said opening of said first cavity; anda reference system disposed in at least a portion of said second cavity.2. The sensor of claim 1 , wherein at least a portion of said substrate is formed from one or more of polymethylmetacrylate claim 1 , 2-hydroxyethyl methacrylate claim 1 , and glass.3. The sensor of claim 1 , wherein at ...

COLORIMETRIC METHOD AND DEVICE FOR DETECTING ANALYTE QUANTITIES IN FLUIDS AND MATERIALS

A method and device for detecting an analyte in a solution or compound mixture use colorimetric detection to detect the quantity of an analyte in the solution or compound. The analyte sensor demonstrates a clear change in peak light absorption wavelength as a function of the stoichiometric relationship between the analyte sensor and the analyte. The method involves combining the analyte sensor and the analyte in solution and observing a color change of the mixture. Additionally, predefined amounts of the analyte sensor can be added until color change is detected and the quantity of analyte can be determined as a function of the total amount of analyte sensor in the mixture. Alternatively, a device having multiple wells or compartments, each with a different concentration of the analyte sensor. The analyte sample can be introduced to each well and the well that demonstrates the color change can, from its know analyte sensor concentration, be used to quickly and accurately determine the concentration of the analyte. 1. A detecting device comprising an analyte sensor that exhibits a predefined change in absorption wavelength , only at a specific stoichiometry of the analyte sensor and the analyte.2. The detecting device according to further comprising at least one well including an analyte sensor compound at a predefined concentration.3. The detecting device according to further comprising a plurality of wells claim 1 , each well including an analyte sensor compound at a predefined concentration.4. The detecting device according to wherein at least two of the plurality of wells have different concentrations of the analyte sensor compound.5. The detecting device according to wherein the analyte is zinc and the analyte sensor is ZPP1.6. The detecting device according to wherein the analyte is zinc and the analyte sensor is BG-29.6. The detecting device according to wherein the analyte sensor compound has a concentration of at least 10 micro molar.7. A device for ...

METHOD FOR DETECTING NUCLEIC ACID, AND DEVICE OR KIT

A method and a device or kit for detecting a nucleic acid, which enable simple and precise visual detection of a nucleic acid amplified by an nucleic acid amplification method, without necessity of special devices are provided. The method for detecting a nucleic acid in a sample comprises: contacting a sample with a dye to react with each other; and observing a substance produced by the reaction with visible light, and evaluating the presence or absence of a nucleic acid by eye. The device or kit for detecting a nucleic acid in a sample comprises: a carrier that holds a dye which can bind to a nucleic acid; a path for passing a sample through the carrier; and an evaluation part for observing a substance produced by the reaction between the sample and the dye with visible light, and evaluating the presence or absence of a nucleic acid by eye. 1. A method for detecting a nucleic acid in a sample , comprising the steps of:(1) contacting a sample with a dye to react with each other; and(2) observing a substance produced by the reaction with visible light, and evaluating the presence of a nucleic acid by eye.2. The detection method according to claim 1 , further comprising a step of:(3) contacting a substance reactable with the dye with the sample, prior to or subsequent to the step (1).3. The detection method according to claim 1 , wherein the dye is a dye whose color tone changes upon treating with an oxidizing agent claim 1 , a reducing agent claim 1 , an acid claim 1 , a base claim 1 , or a pH buffering agent. This application is a Divisional of co-pending application Ser. No. 12/726,680, filed on Mar. 18, 2010; and this application claims priority to Application No. 2009-068181 filed in Japan on Mar. 19, 2009, Application No. 2009-142468 filed in Japan on Jun. 15, 2009, Application No. 2009-176784 filed in Japan on Jul. 29, 2009, and Application No. 2009-176785 filed in Japan on Jul. 29, 2009; and this application claims the benefit of U.S. Provisional Application ...

METHOD FOR DETERMINING PECTIN CONTENT IN PLANT SAMPLE

Disclosed is a method for determining pectin content in a plant sample, comprising the following steps: 1) adding an acidic alcohol solution to the plant sample, then heating the resulting mixture to reflux in a water bath, followed by a first filtration; 2) soaking the filtered residue obtained from the first filtration with an acidic solution, then heating the resulting mixture to reflux in a water bath, followed by a second filtration, then bringing to volume after cooling, obtaining filtrate for later use; 3) adding an acetic acid/sodium acetate buffer solution to treat the filtered residue obtained from the second filtration, then adding a pectinase solution and heating the resulting mixture under vibration in a water bath, followed by a third filtration to obtain a filtrate for later use; 4) sequentially adding an acetic acid/sodium acetate buffer solution and a pectinase solution to the filtrate obtained in step 2) and heating the resulting mixture under vibration in a water bath to obtain an enzymatic hydrolysate, then adding the filtrate obtained in step 3) to the enzymatic hydrolysate followed by bringing to volume, obtaining a test solution; and 5) drawing the test solution into a continuous flow analyzer to perform analysis. The method disclosed has the advantage of providing accurate analysis results. 1. A method for determining pectin content in a plant sample , wherein said method comprises steps of:1) adding an acidic alcohol solution to the plant sample, followed by a heating in a water bath and then a first filtration;2) soaking a filtered residue obtained from the first filtration with an acid solution, followed by a heating in a water bath and then a second filtration, then bringing to volume after cooling, obtaining a filtrate for later use;3) adding an acetic acid/sodium acetate buffer solution to treat a filtered residue obtained from the second filtration, then adding a pectinase solution and heating the resulting mixture under vibration in a ...

Reader Devices for Optical and Electrochemical Test Devices

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

MEASURING DEVICE AND MEASURING METHOD

The device enables measurement of both of blood glucose level and hemoglobin A1c level, being small-sized and thus portable, allowing the measurement of a small amount of a specimen and, being usable in POC. The device comprises: a test-piece-mounting section () for detachably mounting test pieces () on which the blood specimen is to be spotted; a light-emitting section () for emitting light for irradiating the test pieces; a light-receiving section () for receiving reflected lights from the test pieces; and an operating section () for calculating the blood glucose level and hemoglobin A1c level of the blood specimen on the basis of photometric values obtained from the light-receiving section. For measuring the blood glucose level of the blood specimen, test piece (A) carries a composition reacting with glucose and showing color change. Test piece (B) carries a composition reacting with glycated hemoglobin and showing color change. 1. A measuring device for measuring a blood glucose level and a hemoglobin A1c level of a blood specimen , the measuring device comprising:a light-emitting section that emits illuminating light toward the blood specimen;a light-receiving section that receives reflected light from the blood specimen; andan operating section that calculates each of the blood glucose level and the hemoglobin A1c level of the blood specimen on the basis of a photometric value obtained from the light-receiving section,wherein the light-emitting section is capable of emitting two or more types of light having different wavelengths.2. The measuring device according to claim 1 , wherein the light-emitting section is capable of emitting three types of light having different wavelengths.3. The measuring device according to claim 2 , wherein one of the three types of light having different wavelengths is light having a specific wavelength that is absorbed by a portion whose color has changed in response to glucose contained in the blood specimen and the remaining ...

DIAGNOSTIC DEVICE FOR IDENTIFYING RUPTURE OF MEMBRANE DURING PREGNANCY

A diagnostic device is provided for distinguishing between amniotic fluid and urine in female secretion. The device can be employed as a panty shield or can be adhered onto a panty shield or can be employed in a simple pad that is pressed against a substrate provided with female secretion. 1. A dry diagnostic device for quickly distinguishing between amniotic fluid and/or urine in female secretion , provided with a color index ,the device comprising:a base layer; two inert carrier matrices provided on said base layer; dry reagents provided on said two inert carrier matrices wherein said dry reagents are capable of forming a chemical reaction with substances in the female secretion selected from two or more of a group comprising creatinine, alkaline phosphatase and total protein, so as to visually distinguish between the amniotic fluid and urine;the color index configured to allow distinguishing between the amniotic fluid and urine by comparing the colors of the device after contact of the device with amniotic fluid and/or urine to the colors of the index;the reagent capable of forming a chemical reaction with creatinine selected from one or more of a group of dinitro derivatives comprising: 3′5′-dinitrobenzoic acid, 2′4′-dinitrobenzoic acid, 3′5′-dinitrobenzotrifluoride, 3′5′-dinitrobenzamide, 3′5′-dinitrobenzoyl-phenyl glycine, 3,5-dinitrohydroxyphenylpropionic acid;the carrier matrix whereupon the reagent capable of forming a chemical reaction with creatinine is provided further comprising: a buffer capable of keeping a stable pH in a range of about 9 to 13.5, the buffer selected from one or more of a group of: sodium metasilicate, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium hydroxide-potassium chloride, potassium carbonate, glycine—sodium hydroxide, and sodium borate,the reagents capable of reacting with total protein a dye selected from one or more of a group of: 3′,3″,5′,5″-Tetrabromophenolsulfonephthalein, coomassie brilliant blue, Fast ...

OPTICAL SENSOR AND METHOD FOR INDICATING THE AGE OR QUALITY OF A NATURAL PRODUCT

The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their use. 125-. (canceled)27. The device according to claim 26 , wherein said reflecting layer or said nanoparticle layer have a thickness of 1 to 100 nm and said biodegradable polymer layer has a thickness of 5 to 1000 nm.28. The device according to claim 26 , wherein said reflecting layer comprises a mirror layer made of a metal.29. The device according to claim 28 , wherein said mirror layer is made of gold.30. The device according to claim 29 , wherein said mirror layer made of gold has a thickness of 10 to 30 nm.31. The device according to claim 26 , wherein said nanoparticle layer comprises a plurality of island-like structures wherein said islands have a size of 5 to 50 nm in diameter.32. The device according to claim 31 , wherein said nanoparticle layer is made of a metal.33. The device according to claim 32 , wherein said nanoparticle layer is made of gold.34. The device according to claim 33 , wherein said nanoparticle layer made of gold consisting essentially of a plurality of island-like structures claim 33 , wherein said islands have a size of 5 to 50 nm in diameter claim 33 , with a thickness of 2 to 20 nm.35. The device according to claim 26 , wherein said biodegradable polymer layer is degradable by biomolecules comprising enzymes or catabolic metabolites.36. The device according to claim 35 , wherein said biodegradable polymer layer has a thickness of 100 to 500 nm.37. The device according to comprising an additional carrier layer on the reflecting layer or the nanoparticle layer claim 26 , in each case being positioned on the side of the reflecting or the nanoparticle layer opposite of said polymer layer.38. The device according to claim 26 , wherein ...

Self-metering System and Testing Device with Casing and Sliding Member to Cut-off and Set Sample Volume

A testing cartridge for metering of a sample to be tested. The testing cartridge includes a casing defining a casing opening and a sliding member defining a sliding member opening. The casing opening or the sliding member opening can define a specified volume, wherein the casing opening and the sliding member opening collectively define a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume. The sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample. 1. A testing device for metering of a sample , comprising:a casing defining a casing opening; anda sliding member defining a sliding member opening, the casing opening or the sliding member opening defining a specified volume, the casing opening and the sliding member opening collectively defining a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume, wherein the sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample.2. The testing device as claimed in claim 1 , wherein the sliding member is contained within the casing and wherein the casing defines a passage for the transverse movement of the sliding member through the passage of the casing.3. The testing device as claimed in claim 1 , wherein the passage is dimensioned to flushly encompass a cross sectional shape of the sliding member.4. The testing device as claimed in claim 1 , wherein the sliding member opening is defined by enclosed sidewalls of the sliding member.5. The testing device as claimed in ...

Assays for detection of glycosaminoglycans

Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Methods and apparatuses for detecting a corrosion inhibitor

Methods, apparatuses, compositions and kits are disclosed for detecting the presence or absence of an inhibitor in a fluid. In one embodiment, methods, apparatuses, compositions and kits are disclosed for determining if the level of a corrosion inhibitor in a coolant fluid is sufficient to provide protection against corrosion.

BLAST, BALLISTIC AND BLUNT TRAUMA SENSOR

A molecular biosensor is provided including a lipid vesicle and a housing wherein the vesicle is contained on or within the housing and where the housing has a portion capable of transmitting a force generated, external to the housing to the vesicle. The biosensor is used in processes of detecting the presence or absence of an event force such as a blast or blunt force sufficient to produce a medical complication such as traumatic brain injury. 1. A molecular biosensor comprising:a lipid vesicle;a housing, said vesicle contained on or within said housing, said housing having a portion capable of transmitting a force generated external to said housing to said vesicle; andwherein said vesicle comprises phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, sphingomyelin cholesterol, ceramide, or combinations thereof.2. The biosensor of wherein said vesicle consists of phosphatidylcholine.3. The biosensor of wherein said vesicle comprises greater than 50 percent total lipid of phosphatidylcholine claim 1 , phosphatidylethanolamine claim 1 , or a combination thereof claim 1 , andwherein said housing is in the form of a lamellar structure, interlaced sheet, capsule, or tablet.4. The biosensor of wherein said housing is in the form of a capsule.5. The biosensor of wherein said vesicle further comprises a detection agent.6. The biosensor of wherein said detection agent consists of a fluorophore.7. A process for detecting a traumatic event comprising:subjecting a molecular biosensor, to a force; andanalyzing said biosensor for alteration in molecular structure subsequent to applying said force.8. The process of wherein said step of analyzing is by analyzing the lipid vesicle portion of said biosensor.9. The process of wherein said step of analyzing is by analyzing a solution external to a lipid vesicle portion of said biosensor for the presence or absence of a detection agent.10. The process of wherein said vesicle comprises ...

METHODS FOR DETERMINING A WAVEFRONT POSITION ON A TEST STRIP

The present disclosure relates to methods for determining a wavefront position of a liquid on a surface of an assay test strip placing a liquid on the surface of the test strip; and acquiring one or more signals from the surface of the test strip at one or more times, comparing the one or more acquired signals to a threshold, wherein the wavefront position is a position on the surface of the test strip where a signal is greater than or less than a threshold (e.g., fixed or dynamic threshold). Such methods may be used to determine the wavefront velocity of a liquid on a surface of an assay test strip and the transit time of a liquid sample to traverse the one or more positions on the surface of the assay test strip. 1. A method for determining a transit time of a liquid to cross from a first position to a second position on the surface of a test strip , said method comprising:placing a liquid on the surface of the test strip;acquiring a first signal from a first position of the surface of the test strip which corresponds to a starting time for the assay;acquiring two or more additional signals from the surface of the test strip;comparing the two or more additional signals to a threshold to determine a liquid front position, wherein the liquid front position is a position on the surface of the test strip where a difference between the two or more additional signals is greater than or less than the threshold;identifying a time at which the liquid front position crosses the second position on the surface of the test strip,wherein the transit time of the liquid to cross the surface of the test strip is the time between the acquisition of the first signal and the time at which the liquid front position crosses the second position on the surface of the test strip.2. The method of claim 1 , wherein the two or more additional signals are subtracted from a constant prior to being compared to the threshold.3. The method of claim 1 , wherein the two or more additional signals ...

Method and Device for Detection of an Analyte

The present invention relates to a method, device, and kit for analyzing a sample for determining the presence or amount of an analyte, particularly carbohydrate, more particularly sugar, in the sample using a fabric. 1. A method of determining the presence or amount of an analyte in a sample , said method comprising:applying the sample to a fabric;chemically modifying said analyte if present in the sample;detecting the presence or amount of said chemically-modified analyte.2. A method according to wherein the analyte is a carbohydrate.3. A method according to wherein the carbohydrate comprises a sugar.4. A method according to wherein the sugar comprises fructose claim 3 , dextrin claim 3 , lactose claim 3 , maltose or sucrose.5. A method according to wherein the chemical modification and detection are carried out at room temperature.6. A method according to wherein the chemical modification and detection are carried out in separate regions of the fabric.7. A method according to which further comprises inactivating an agent which would interfere with the detection of chemically-modified analyte.8. A method according to wherein the chemical modification and inactivation of interfering agent are carried out before detecting the chemically-modified analyte.9. A method according to wherein the chemical modification is reaction with an oxidant to open an ether linkage in a sugar ring and/or to produce an aldehyde group.10. A method according to wherein the chemical modifying agent is periodic acid or a periodate salt.11. A method according to in which after the chemical modification reaction and before the detection of the chemically-modified carbohydrate claim 9 , excess oxidant which would interfere with the detection of the chemically-modified carbohydrate is inactivated.12. A method according to wherein detection of the chemically-modified carbohydrate is with a copper-containing compound to give a visible colour change in the presence of the chemically-modified ...

Composition and Sensor for Detecting Occult Blood

An occult blood detection composition is used for various applications including that of predicting the start of menstruation. The composition may be applied to various devices to create a sensor, such devices include a feminine pad or shield, a badge, a swab or a wipe. The composition may be part of a kit wherein one component of the composition is applied to a device for the consumer. The remaining component of the composition, in liquid form, is applied to the device by the consumer prior to use. 1. A composition for detecting occult blood comprising:a benzoyl leuco methylene blue dye;a dye stabilizer;a color enhancer; andan oxidant.2. The composition of comprising 0.1 to 20% benzoyl leuco methylene blue dye.3. The composition of comprising 3% benzoyl leuco methylene blue dye.4. The composition of wherein the chromogen stabilizer comprises triethanolamine borate.5. The composition of comprising 1 to 15% triethanolamine borate.6. The composition of wherein the color enhancer comprises 6-methoxyquinoline.7. The composition of wherein comprising 1 to 20% 6-methoxyquinoline.8. The composition of further comprising a surfactant selected from the group consisting of sodium dodecyl sulfate claim 1 , dimethyl; sulfone and combinations thereof.9. The composition of further comprising 5 to 40% surfactant.10. The composition of further comprising a preservative selected from the group consisting of citric acid claim 1 , sodium citrate and combinations thereof.11. The composition of further comprising a ethylenediaminetetraacetic acid claim 1 , disodium salt.12. A sensor for detecting occult blood comprising an article having a surface onto which the composition of is applied claim 1 , the article selected from the group consisting of a wipe claim 1 , a badge claim 1 , a swab and a feminine care article.13. A sensor for detecting occult blood comprising:a substrate having a body-facing surface and an opposite garment facing surface;wherein an occult-blood detecting ...

Devices and Formulations for Detecting, Screening and Monitoring Levels of Certain Constituents in Bodily Fluids and Method

A device and method are disclosed for use in the conduct of a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid, which analysis utilizes an indicator formulation that changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid. A stabilizing formulation is carried in a vessel for mixing with a sample of the bodily fluid to be analyzed. The stabilizing formulation includes a first component for promoting formation of a film, a second component for adjusting the pH of the sample and inhibiting microbial digestion of the certain constituent carried by the bodily fluid, and a third component for reducing interference of ascorbic acid present in the bodily fluid. Where the certain constituent is glucose, the stabilizing formulation includes a microbial digestion inhibitor. 1. A device for use in the conduct of a non-invasive analysis of a bodily fluid to determine the presence and the level of a certain constituent carried by the bodily fluid , in which analysis an indicator formulation capable of changing color in response to exposure to the certain constituent provides a visible indication of the presence and the level of the certain constituent carried by the bodily fluid , the device comprising:a vessel having a receptacle for receiving a sample of the bodily fluid;a receptor construct within the vessel in juxtaposition with the receptacle;a stabilizer formulation carried by the receptor construct in position to be exposed to the sample of the bodily fluid upon introduction of the sample into the receptacle; a first component for promoting formation of a film;', 'a second component for adjusting the pH of the sample and inhibiting microbial digestion of the certain constituent carried by the bodily fluid; and', 'a third component for reducing interference of ascorbic acid present in the ...

TEST STRIP CARD

The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. 1. A test strip card for testing a property of a fluid specimen , said test strip card comprising:a comparison scale that comprises a continuous scale of visual levels;a test strip having (a) a reaction zone which is part of a reagent pad and (b) a zone that is not part of the reaction zone, the test strip being movably coupled to said test strip card for performing a reaction on the reaction zone on the reagent pad of the test strip; anda window along said comparison scale for viewing (a) the reaction zone of the test strip and (b) at least a portion of the zone of the test strip that is not part of the reaction zone,wherein said test strip is movable with respect to said comparison scale to align said reaction zone with a matching visual level on said comparison scale whereby indicating the property of the specimen.2. The test strip card of claim 1 , wherein:said test scale card further comprises a front wall, a back wall, and a pocket between said front wall and said back wall; andsaid test strip is movably located within said pocket in said test scale card.3. The test strip card of claim 2 , wherein:said window is formed in said front wall along said comparison scale; and part of said reaction zone on said test strip is visible through said window along said comparison scale.4. (canceled)5. The test strip card of claim 2 , wherein said test strip has a pull end extending beyond the borders of said front wall and said back wall.6. The test strip card of claim 2 , wherein;a notch is defined at an end of at ...

METHOD FOR DETERMINING AN ANALYTE IN AN AUTOMATED MANNER

A method for determining an analyte of a liquid sample in a cuvette includes providing a cuvette, a reagent, a barcode, an icon on the cuvette and a liquid analysis device comprising a photometer, a rotation device, a camera, a calibration data memory storing first calibration data, and an input device which manually inputs second calibration data. The cuvette is inserted into the liquid analysis device and is rotated to align the icon with the camera. The icon is read with the camera and the icon read compared with an icon model stored in the liquid analysis device to determine whether it corresponds thereto. The liquid sample is subjected to photometry based on the first calibration data if the icon read corresponds to the icon model. If not, the input apparatus is activated and the liquid sample is subjected to photometry on the basis of the second calibration data. 18-. (canceled)9. A method for automatically determining an analyte of a liquid sample in a cuvette in a liquid analysis device , the method comprising:providing a cuvette which is configured to be cylindrical;providing a reagent which is configured to react with the analyte in a color-changing manner;providing a barcode configured either as a one-dimensional barcode or as a two-dimensional barcode;providing an icon with two dimensions on an outside of the cuvette; a photometer,', 'a rotation device which is configured to rotate a cuvette inserted in the liquid analysis device,', 'a camera which is configured to read the barcode and the icon,', 'a calibration data memory which is configured to store first calibration data associated with the reagent, and', 'an input device which is configured to manually input second calibration data associated with the reagent;, 'providing a liquid analysis device comprising'}inserting the cuvette into the liquid analysis device;rotating the cuvette so as to align the icon with the camera;reading the icon with the camera;comparing the icon read with an icon model ...

IMMUNOCHROMATOGRAPHIC ASSAY METHOD AND APPARATUS

In an immunochromatographic assay method for performing an assay related to a specimen by reacting a reagent held by a carrier and the specimen with each other, and by obtaining an image signal by imaging a reagent portion by a camera, and by measuring, based on the image signal, the color-developed state of the reagent, a morphological opening-operation is applied to the image signal by using a structuring element the size of which is less than or equal to a signal-change-width of the reagent portion that has developed color, and a morphological opening-operation is applied to the image signal by using a structuring element the size of which is larger than the signal-change-width of the reagent portion that has developed color. The color-developed state is measured based on a difference signal obtained by performing a subtraction between the image signals to which the opening-operations have been applied respectively. 1. An immunochromatographic assay method for performing an assay related to a specimen by reacting a reagent held by a carrier and the specimen with each other , and by obtaining an image signal by imaging a reagent portion that has been reacted , and by measuring , based on the image signal , the color-developed state of the reagent caused by the reaction ,the method comprising:applying a morphological opening operation to the image signal by using a structuring element the size of which is less than or equal to a signal change width of the reagent portion that has developed color;applying a morphological opening operation to the image signal by using a structuring element the size of which is larger than the signal change width of the reagent portion that has developed color;obtaining a difference signal by performing a subtraction between the image signals to which the opening operations have been applied respectively; andmeasuring the color-developed state based on the difference signal.2. An immunochromatographic assay method for performing an ...

IMMUNOCHROMATOGRAPHIC ASSAY METHOD AND APPARATUS

In an immunochromatographic assay method for assaying a specimen by reacting a reagent held by a carrier and the specimen with each other, and by obtaining an image signal by imaging a reagent portion that has been reacted, and by measuring, based on the image signal, the color-developed state of the reagent caused by the reaction, the carrier holds reagents in such a manner that they do not extend continuously for the full length of the carrier in any one of two-dimensional directions along the surface of the carrier. A morphological opening operation is applied to the image signal, with respect to each of the two-dimensional directions, by using a structuring element the size of which is less than or equal to a signal change width of the reagent portion that has developed color, and the color-developed state is measured based on the image signal after the opening operation. 1. An immunochromatographic assay method for performing an assay related to a specimen by reacting a reagent held by a carrier and the specimen with each other , and by obtaining an image signal by imaging a reagent portion that has been reacted , and by measuring , based on the image signal , the color-developed state of the reagent caused by the reaction ,wherein the carrier holds the reagent in such a manner that the reagent does not extend continuously for the full length of the carrier in any one of two-dimensional directions along the surface of the carrier,the method comprising:applying a morphological opening operation to the image signal, with respect to each of the two-dimensional directions, by using a structuring element the size of which is less than or equal to a signal change width of the reagent portion that has developed color; andmeasuring the color-developed state based on the image signal after the opening operation.2. An immunochromatographic assay method claim 1 , as defined in claim 1 , the method comprising:applying a morphological opening operation to the image signal ...

MEDICAL FLUID ACCESS DEVICE WITH ANTISEPTIC INDICATOR

A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent. The indicator includes a substrate and a microporous layer disposed on the substrate. The microporous layer is made from a polymer material having an index of refraction from about 1.25 to about 1.6 and is configured to change from a substantially opaque state to a substantially transparent state upon exposure to an antiseptic solution. The microporous layer resumes the substantially opaque state after a period of time. 1. An antiseptic indicator comprising:a substrate; anda microporous layer disposed on the substrate, the microporous layer made from a polymer material having an index of refraction from about 1.25 to about 1.6 and configured to change from a substantially opaque state to a substantially transparent state upon exposure to an antiseptic solution, and wherein the microporous layer resumes the substantially opaque state after a period of time.2. The indicator of claim 1 , wherein the microporous layer includes a membrane configured to be resistant to blood staining.3. The indicator of claim 1 , wherein the microporous layer includes a membrane having a morphology with particle-like structures.4. The indicator of claim 1 , wherein the microporous layer is a membrane made by a liquid/liquid phase separation process.5. The indicator of claim 1 , wherein the microporous layer is directly formed on a housing of a medical fluid access device.6. The indicator of claim 5 , wherein the substrate is formed in proximity to a connector attached to the housing claim 5 , and wherein wiping or swabbing the connector with an antiseptic agent also exposes the microporous layer to the antiseptic agent.7. The indicator of claim 1 , further ...

TIME-TEMPERATURE INDICATING DEVICE

The present invention is generally in the field of measuring and indicating techniques and relates to a time-temperature indicating device and methods of manufacturing and reading this device. More specifically, the time-temperature indicator (TTI) device comprises at least one active reactant being at least a part of a component that is configured to be either an electrical component or transformable into an electrical component, said at least one active reactant being selected to be affectable by a chemical and/or physical reaction effecting a change in at least an electrical property of said electrical component at a rate that is time-temperature dependent. 1. A time-temperature indicator device comprising at least one active reactant being at least a part of an electrical component , said at least one active reactant is selected such it intrinsically changes at least an electrical property of said electrical component at a rate that is time-temperature dependent.2. A time-temperature indicator device comprising(i) at least one active reactant being at least a part of an electrical component, said at least one active reactant being selected to be affectable by a chemical and/or physical reaction effecting a change in at least an electrical property of said electrical component at a rate that is time-temperature dependent; and(ii) at least one first passive reactant in the form of a viscous substance, said chemical and/or physical reaction being a reaction between said at least one active reactant and said at least one first passive reactant and wherein said at least one first passive reactant is selected such that it causes time-temperature dependent development of said chemical and/or physical reaction.3. A time-temperature indicator device comprising(i) at least one active reactant being at least a part of an electrical component, said at least one active reactant being selected to be affectable by a chemical and/or physical reaction effecting a change in at ...

A METHOD AND DEVICE FOR DETECTING ALKYLATING AGENTS

A method is provided for detecting alkylating agents, the method comprising bringing together a first solvent, one or more surfactants, a base, a reagent comprising a nucleophilic nitrogen atom, and a suspected alkylating agent. A device suitable for putting said method into effect is also provided. 1. A method for detecting alkylating agents , the method comprising:bringing together a first solvent, one or more surfactants, a base, a reagent comprising a nucleophilic nitrogen atom, and a suspected alkylating agent.2. The method according to comprising providing a micelle-containing solution comprising the first solvent and one or more surfactants claim 1 , and bringing together the micelle-containing solution claim 1 , the suspected alkylating agent claim 1 , said reagent comprising a nucleophilic nitrogen atom and the base.3. The method according to comprising bringing together the first solvent claim 1 , a second solvent which is substantially immiscible with the first solvent claim 1 , the one or more surfactants claim 1 , the base claim 1 , the reagent comprising a nucleophilic nitrogen atom and the suspected alkylating agent claim 1 , wherein the reagent comprising a nuclephilic nitrogen atom is soluble in the second solvent.4. The method according to comprising providing a microemulsion comprising the first solvent claim 3 , the second solvent and one or more surfactants claim 3 , and bringing together the microemulsion claim 3 , the suspected alkylating agent claim 3 , the reagent comprising a nucleophilic nitrogen atom and the base.5. The method according comprising sensing for the formation of colouration.6. The method according to comprising sensing the speed of formation of colouration claim 5 , the speed of formation of colouration being indicative of the reactivity of the alkylating agent and/or the concentration of the alkylating agent.7. (canceled)8. The method according to comprising sensing for a change in colouration claim 5 , and adding further ...

ESTROUS CYCLE MONITORING BY COLOR RESPONSE

A method of determining the phase of an estrous cycle that a mammal is in at a given time that a biological sample is obtained from the mammal is provided. The biological sample obtained from the mammal is combined with a flavonol and an anthocyanin and/or iodine on, or which had been stored on and subsequently removed from, a silane-based surface to provide a color response. The estrus phase of the estrous cycle has a corresponding color response that is distinguishable from the color response of each other phase of the estrous cycle to an unaided human eye. The corresponding color response is correlated to the estrus phase of the estrous cycle. 1. A method of determining the phase of an estrous cycle that a mammal is in at a given time that a biological sample is obtained from the mammal , comprising combining the biological sample obtained from the mammal with a flavonol and subsequently combining the biological sample with an anthocyanin pigment on , or which had been stored on and subsequently removed from , a silane surface to induce a reaction that provides a color response , the estrus phase of the estrous cycle having a corresponding color response to the flavonol and the anthocyanin pigment that is distinguishable to an unaided human eye from the color responses of each other phase of the estrous cycle , and correlating the corresponding color response to the estrus phase of the estrous cycle.2. The method of claim 1 , wherein each phase of the estrous cycle has a corresponding color response that is distinguishable to the unaided human eye from the color responses of each other phase of the estrous cycle.3. The method of claim 1 , wherein the anthocyanin pigment has a three-position carbon with a first O-glycosyl group and a five-position carbon with a second O-glycosyl group.4. The method of claim 3 , wherein the anthocyanin pigment comprises a member selected from the group consisting of cyanidin 3 claim 3 ,5-diglycoside claim 3 , petunidin 3 claim 3 ,5 ...

Analytical Device with Base Module and Exchangeable Cassette

An analytical device for automated determining of a measured variable of a liquid sample, includes: a base module; a replaceable cassette connectable with the base module and having at least one liquid container connectable via a fluid line with a measuring cell and containing a reagent to be added to the liquid sample for forming a measured liquid; and a measuring transducer for registering measured values correlated with the measured variable for the measured liquid accommodated in the measuring cell. The cassette has, associated with the at least one liquid container, a fluid coupling apparatus having a primary component and a secondary component and serving for producing a connection of the fluid line with the liquid container. 115-. (canceled)16. An analytical device for automated determining of a measured variable of a liquid sample , comprising:a base module;a measuring cell;a fluid line;a replaceable cassette connectable with said base module and having at least one liquid container connectable via said fluid line with said measuring cell and containing a reagent to be added to the liquid sample for forming a measured liquid;a measuring transducer for registering measured values correlated with the measured variable for the measured liquid accommodated in said measuring cell; anda fluid coupling apparatus, wherein:said replaceable cassette has, associated with said at least one liquid container, said fluid coupling apparatus having a primary component and a secondary component and serving for producing a connection of said fluid line with said at least one liquid container.17. The analytical device as claimed in claim 16 , wherein:said base module and said replaceable cassette are separate components and each comprises complementary mechanical connecting means for providing a releasable connection between said replaceable cassette and said base module;said replaceable cassette includes locking means to prevent movement of said secondary component relative to ...

COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID COMPOUND

The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample. 1. A composition for colorimetric analysis comprisingan enzyme;a chromogenic reaction product; anda sulfonic acid.3. The composition of wherein R is methyl claim 2 , ethyl claim 2 , propyl claim 2 , —NH claim 2 , or mixtures thereof.5. The composition of wherein the sulfonic acid is present in an amount in the range of 0.02 M to 2.0 M.6. The composition of wherein the sulfonic acid has a pKa in the range of about −2.5 to 4.7. The composition of wherein the pH of the composition is in the range of about 0.2 to about 4.8. The composition of wherein the chromogenic reaction product is an oxidized product.9. The composition of wherein the chromogenic reaction product is an oxidized tetramethylbenzidine (TMB) compound.10. The composition of wherein the enzyme is a peroxidase or an oxidase.11. The composition of wherein the peroxidase and/or oxidase is selected from horseradish peroxidase claim 10 , soybean peroxidase claim 10 , glucose oxidase claim 10 , galactose oxidase claim 10 , xanthine oxidase claim 10 , lactoperoxidase claim 10 , microperoxidase claim 10 , NADH peroxidase NADPH peroxidase claim 10 , fatty-acid peroxidase claim 10 , and catalase.12. A method of conducting colorimetric analysis comprising the steps of:(a) providing a reaction composition comprising an enzyme and a chromogenic substrate;(b) allowing the reaction composition to form a chromogenic reaction product;(c) adding a ...

DRY CHEMISTRY, LATERAL FLOW-RECONSTITUTED CHROMATOGRAPHIC ENZYME-DRIVEN ASSAYS

A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desired reaction, are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final “read zone” wherein the color developed is read against predetermined color standards for the desired reaction. Pretreatment pads for the sample, as needed, are placed in front of the sample pad in the flow path as appropriate. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays. 119-. (canceled)20. An assay device comprising at least two pads in fluid communication and positioned on an adhesive backing , wherein(1) the first pad is a sample receiving pad adapted to receive a sample which flows through the sample receiving pad, and(2) the second pad is a substrate pad on which has been deposited a mobilizable dry mixture of components including a substrate for an enzyme, which components, when reconstituted by forward flow of the sample, perform an assay on the sample.21. The assay device of claim 20 , wherein a result of the assay performed on the sample is determined by a color indicative of the presence or concentration of the enzyme in the sample.22. The assay device of claim 20 , wherein a region of the first pad has been treated to remove or reduce the concentration of a substance in ...

METHOD FOR PRESERVING AQUEOUS SOLUTION CONTAINING LEUCO CHROMOGEN

The present invention provides: a method for preserving an aqueous solution containing a leuco chromogen, comprising adding a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof to the aqueous solution containing a leuco chromogen; a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof; and a liquid reagent comprising a leuco chromogen and a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof. 1. A method for preserving an aqueous solution containing a leuco chromogen , comprising adding a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof to the aqueous solution containing a leuco chromogen.2. A method for stabilizing a leuco chromogen , comprising allowing the leuco chromogen to coexist in an aqueous solution comprising a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a metal ion or a salt thereof.4. The method according to claim 1 , wherein the leuco chromogen is a phenothiazine chromogen.5. The method according to claim 4 , wherein the phenothiazine chromogen is 10-(carboxymethylaminocarbonyl)-3 claim 4 ,7-bis(dimethylamino)phenothiazine.6. A liquid reagent comprising a leuco chromogen and a compound having at least one substituent selected from the group consisting of a nitroso group and an azo group and having an ability to coordinate a ...

TEST STRIPS AND METHOD FOR READING TEST STRIPS

A specimen test strip is provided to detect a characteristic of an analyte in a specimen sample. The specimen test strip includes a reaction area to receive the specimen sample and a color calibration area to determine a color, or a color and a color intensity, of the reaction area after receiving the specimen sample. The specimen test strip may further include a temperature indication area to correct a measurement of the characteristic of analyte. 1. A specimen test strip to detect a characteristic of an analyte in a specimen sample , comprising:a reaction area configured to receive the specimen sample; anda color calibration area configured to determine a color of the reaction area after receiving the specimen sample.2. The specimen test strip of claim 1 , wherein the color calibration area is configured to determine a color intensity in addition to the color of the reaction area after receiving the specimen sample.3. The specimen test strip of claim 1 , further comprising a temperature indication area configured to correct a measurement of the characteristic of analyte.4. The specimen test strip of claim 1 , wherein the color calibration area surrounds the reaction area.5. The specimen test strip of claim 4 , wherein the color calibration area comprises a ring-shaped area.6. The specimen test strip of claim 1 , wherein the color calibration area comprises a dummy reaction area that remains a same color or colors.7. The specimen test strip of claim 6 , wherein the dummy reaction area is devoid of any dye.8. The specimen test strip of claim 6 , wherein the dummy reaction area is devoid of any enzyme.9. The specimen test strip of claim 1 , wherein the color calibration area comprises a color chart or a gray card.10. The specimen test strip of claim 1 , further comprising a timer capillary to receive the specimen sample claim 1 , the timer capillary being marked off with time durations.11. The specimen test strip of claim 1 , further comprising a timer area to ...

Color-Based Reaction Testing of Biological Materials

A biological material test strip and adjacently-located reference color chart are affixed to a lid portion of an all-in-one specimen cup to perform color-based reaction testing of collected biological specimens in an uncalibrated environment. After specimen collection, the lid portion is secured to a container portion of the specimen cup. The cup may then be rotated into an upside down position causing the specimen, under the force of gravity, to pass from the container portion and into a volume of the lid portion, such that the test strip is exposed to the specimen as it is received into the volume of the lid portion. An image of the exposed test strip and adjacently-located reference color chart may then be captured and processed to identify any color matches between the individual test pads on the test strip and the corresponding sequences of reference color blocks on the reference chart. 120-. (canceled)21. A method for color-based reaction testing of biological materials comprising the acts of:capturing, by an electronic device using ambient lighting in an uncalibrated environment, digital image information of an exposed test strip and of a reference color chart, wherein the digital image information of each of the exposed test strip and the reference color chart is captured in the same uncalibrated environment, wherein the exposed test strip comprises a plurality of test pads, and wherein further the reference color chart comprises a plurality of color blocks;locating, by a diagnostic software application that is executing on the electronic device, first image data within the digital image information corresponding to each of the plurality of test pads, said first image data having uncalibrated color information;locating, by the diagnostic software application executing on the electronic device, second image data within the digital image corresponding to the plurality of color blocks on the reference color chart, said second image data having uncalibrated ...

SYSTEMS AND METHODS FOR NON-FASTING LDL CHOLESTEROL ASSAYS

In one embodiment, a test strip for testing for cholesterol-related blood analytes in whole blood includes a red blood cell separation layer, the red blood cell separation layer separating red blood cells from a blood sample applied to the test strip as the blood sample flows downward through the red blood cell separation layer. The test strip further includes a reaction layer receiving the blood sample from the red blood cell separation layer, the reaction layer including POE-POP-POE block copolymer, a surfactant, and a reflectivity changing reactant, the POE-POP-POE block copolymers solubilizing essentially only non-LDL cholesterol analytes, the non-LDL cholesterol analytes reacting with the reflectivity changing reactant in order to change a reflectivity of the blood sample. 1. A test strip for testing for cholesterol-related blood analytes in whole blood , the test strip comprising:a red blood cell separation layer, the red blood cell separation layer separating red blood cells from a blood sample applied to the test strip as the blood sample flows downward through the red blood cell separation layer; anda reaction layer receiving the blood sample from the red blood cell separation layer, the reaction layer including POE-POP-POE block copolymer, a surfactant, and a reflectivity changing reactant, the POE-POP-POE block copolymers solubilizing essentially only non-LDL cholesterol analytes, the non-LDL cholesterol analytes reacting with the reflectivity changing reactant in order to change a reflectivity of the blood sample.2. The test strip of claim 1 , further comprising a spreading layer claim 1 , oriented on top of the red blood cell separation layer.3. The test strip of where the POE-POP-POE block copolymer is selected from the list consisting of Pluronics L101: MW 3800 claim 1 , POE-POP-POE; Pluronics L121: MW 4400 claim 1 , POE-POP-POE; Pluronics P123: MW 5750 claim 1 , POE-POP-POE; and{'sub': 106', '70', '106, 'Pluronics F127: MW 12600; POE-POP-POE.'}4. The ...

VERSATILE DRUG TESTING DEVICE

A versatile drug testing device (a lateral flow diagnostic testing device) includes a flat transparent carrier with a top and a bottom with the carrier having a series of independent parallel grooves formed therein running from adjacent to the top to adjacent to the bottom of the carrier, each groove having a first opening and a second opening above the first opening therein adjacent to the bottom of the carrier, at least one drug test strip installed in one of said grooves with its absorbent pad contiguous to the openings and a cover layer attached to the carrier operable to sealing close each of said grooves whereby the bottom of the device can be immersed in a specimen of urine, body fluid, or other biological specimen to wet the pad of the at least one test strip though the ingress of the specimen though the associated openings and the test results on the test strip can be easily viewed through the transparent carrier. Because of the unique construction the device will give accurate reading if temporarily immersed in the specimen or left in the specimen for an extended period of time, making it very user friendly. 1. A device comprising:a carrier having a plurality of groove formations in a face of the carrier, wherein the plurality of groove formations are formed such that, in operation, the plurality of groove formations receive test strips therein;a base opening at a first position in the face of the carrier within a first groove of the plurality of groove formations, in operation, a sample pad of a first test strip in the first groove is exposed to a fluid in contact with the face of the carrier through the base opening;a bleed port as a second position above the first position in the face of the carrier within the first groove, in operation, the sample pad of the first test strip in the first groove is exposed through the bleed port to the fluid;wherein, in operation, when the carrier is submerged in the fluid, a first fluid pressure existing at the base ...

CRYSTALLIZED DIACETYLENIC INDICATOR COMPOUNDS AND METHODS OF PREPARING THE COMPOUNDS

Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds. 139-. (canceled)40. A time-temperature indicator comprising:a crystallized diacetylenic compound capable of polymerizing in the solid state to provide an irreversible appearance change in an environmental condition indicator; anda substrate onto which the crystallized diacetylenic compound is applied;wherein a change in appearance of the crystallized diacetylenic compound is detectable in a manner that is useful to indicate an ambient condition; {'br': None, 'R′NHCONH—R—C≡C—C≡C—R—NHCONHR′'}, 'wherein the crystallized diacetylenic compound is symmetrically substituted and having the structural formulawherein R is methylene, ethylene, propylene or butylene, R′ is a linear alkyl group having from 1 to 21 carbon atoms, the crystallized diacetylenic compound having a crystal structure wherein the crystallized diacetylenic compound molecules have a center-to-center separation, referring to the geometric centers of diacetylene units in adjacent molecules, of less than 4.7 Å, the center-to-center separation being in a direction wherein solid-state polymerization can occur.41. The time-temperature indicator of wherein the center-to-center separation corresponds to a unit cell repeat distance of the crystallized diacetylenic compound.42. The time-temperature indicator of wherein R′ is butyl claim 40 , octyl claim 40 , dodecyl or octadecyl.43. The time-temperature indicator of claim 40 , wherein the crystallized diacetylinic compound comprises two hydrogen bonds for ...

NON-TOXIC SOLVENT FOR CHROMOGENIC SUBSTRATE SOLUTION AND USES THEREOF

The present invention relates to a non-toxic dipolar solvent for chromogenic substrate for detecting presence of lacZ gene and/or gene activity, which comprises a stabilizing amount of a solubilizing agent. The present invention also relates to a method for inducing lac operon in screening assay, comprising the step of contacting an agar plate with at least one essential oil in a concentration sufficient to induce the lac operon. The present invention further relates to a method for detecting the presence of bacteria, comprising the step of contacting an agar plate with at least one essential oil in a concentration sufficient to induce detection of the bacteria. 1. A solvent for a chromogenic substrate for detecting presence , activity , expression , and/or non-expression of a lacZ gene , the solvent comprising at least one compound selected from the group consisting of 1-methylpyrrolidone (NMP) ,{'sup': '1', 'N-dimethyl propylene urea (DMPU),'}propylene carbonate (PC),{'i': 'Abies alba, Aniba roseodora, Cedrus atlantica, Citrus aurantifolia, Citrus aurantium, Citrus bergamia, Citrus limon, Citrus paradisi, Citrus reticulata, Citrus sinensis, Cupressus sempervirens, Juniperus communis, Juniperus virginiana, Picea mariana, Pinus pinaster, Pinus sylvestris, Ravensara aromatica, Rosmarinus officinalis', 'an essential oil selected from the group consisting of , citrus extracts, pine terpenoids, conifers extracts, limonene oil, linseed oil, and combinations thereof,'}and combinations thereof.2. The solvent of where the compound is at a concentration sufficient to maintain substrate activity for more than six months in solution at 4° C.3. The solvent of being a microemulsion.4. The solvent of as a ready-to-use non-toxic liquid.5. A composition for detecting the presence of lacZ gene comprising the solvent of and an effective amount of chromogenic substrate selected from the group consisting ofsubstituted indolyl-β-D-galactoside,halo-substituted indolyl-β-D-galactoside5- ...

URINE TEST SHEET

A urine test sheet which can reduce the workload of a person performing a test through the use of a urine test sheet, caused by the above-mentioned temporary restriction and which makes it possible to obtain a determination result having high reliability. The urine test sheet includes a support, and a reaction reagent which is formed on the support, and by the urine test sheet being immersed in urine to be a specimen and then being taken out, shows a reaction for a prescribed subject to be tested after a prescribed period of time, wherein a detection member in a pad-like shape including the reaction reagent and a reaction-terminating agent having an action causing the reaction to terminate is formed on the support, the reaction-terminating agent is covered with a water-soluble material, and the water-soluble material causes the reaction-terminating agent to act by being dissolved by moisture in the urine. 2. The urine test sheet according to claim 1 , whereinthe amount of the water-soluble material is set so as to cause the reaction-terminating agent to act and to terminate a reaction of the reaction reagent after each of the prescribed periods of time specified for each of the subjects to be tested.3. The urine test sheet according to claim 1 , whereinthe detection member is formed by arranging, in a layered form, the reaction reagent and the reaction-terminating agent covered with the water-soluble material.4. The urine test sheet according to claim 1 , whereinthe detection member is formed by covering the whole outer surface of the reaction-terminating agent with the water-soluble material to thereby be formed into a granular shape, and by containing, in a plural number, the reaction-terminating agent in the granular shape in the reaction reagent.5. The urine test sheet according claim 1 , whereindetection members corresponding to two or more subjects to be tested which are different in the prescribed period of time are formed on the support, and around each of ...

SYSTEM FOR WATER AND FOOD SAFETY TESTING

A system for testing for environmental contaminants using strip tests, obtaining and uploading images of strip tests into a processor, associating a test data set including location, time, and date of test with each image, determining a test result through computational analysis of each image, and storing and reporting test results and data sets. 1. A method of generating a test result which measures the presence of a contaminant in a test solution , comprising:a) immersing a strip test in said test solution, said strip test having an absorbent pad which is chemically treated to change color to indicate concentration of a contaminant;b) removing said test strip from said test solution and generating a digital image of said test strip;c) generating a test data set and associated said test data set with said image;d) uploading said image and said test data to a first processer; ande) using software present on said central processor to generate a test result using computational analysis of said image.2. The method of further comprising the step of transmitting said test result to a second processer in a location remote from said first processer.3. The method of wherein said test data comprises the time said image was generated and the location of a device used to generate said image.4. The method of wherein said processor evaluates placement of said strip test within said image and generates and transmits an error message if said placement does not comply with predetermined parameters.5. The method of wherein said image is generated by said second processor claim 2 , and said second processer is wirelessly interconnected with said first processor claim 2 , and said second processor generates data associated with said image.6. The method of wherein said first processor is adapted to aggregate multiple test results into one or more reports based on one or more commonalities within test data sets.7. The method of further comprising the step of aligning a test square ...

ASSAY METHOD

The invention provides an assay method for determining a level of haptoglobin in a sample comprising the steps of: (i) mixing haemoglobin with the sample to be assayed so as to form a haptoglobin-haemoglobin complex with haptoglobin present in the sample; (ii) contacting the product of step (i) with reagents for generating hydrogen peroxide and one or more chromogens which undergo a spectroscopically detectable change when peroxidase activity is present, in the presence of a buffer, under conditions in which hydrogen peroxide is generated from said reagents and forms a substrate for the peroxidise activity of the haptoglobin-haemoglobin complex present, and wherein the pH of the buffer is within a range which is sufficiently low that the peroxidise activity of any uncomplexed haemoglobin is substantially suppressed but sufficiently high that hydrogen peroxide generation occurs; (iii) determining the peroxidase activity of the haptoglobin-haemoglobin complex by measuring the change in an optical property of the reaction mixture; and (iv) correlating the level of peroxidise activity of the haptoglobin-haemoglobin complex with the amount of haptoglobin in the sample. A kit for use in such a method is also provided. 1. A method for determining a level of haptoglobin in a sample said method comprising:mixing haemoglobin with the sample to be assayed so as to form a haptoglobin-haemoglobin complex with haptoglobin present in the sample;(ii) contacting the product of step (i) with reagents for generating hydrogen peroxide and one or more chromogens which undergo an optically detectable change when peroxidase activity is present, in the presence of a buffer, under conditions in which hydrogen peroxide is generated from said reagents and forms a substrate for the peroxidise activity of the haptoglobin-haemoglobin complex present, and wherein the pH of the buffer is within a range which is sufficiently low that the peroxidise activity of any uncomplexed haemoglobin is ...

METHOD FOR DETECTING A WOUND INFECTION

The present invention relates to a method for detecting a wound infection comprising the steps of: contacting a sample obtained from a wound with at least two substrates for at least two enzymes selected from the group consisting of lysozyme, elastase, cathepsin G and myeloperoxidase, and detecting a wound infection when a conversion of the at least two substrates with said at least two enzymes are determined. 1. A wound dressing or swab comprising at least two substrates for at least two enzymes selected from the group consisting of lysozyme , elastase , cathepsin G and myeloperoxidase , wherein said substrates are capable of releasing a coloured agent or causing declouding.2. The wound dressing or swab according to claim 1 , characterised in that the wound dressing or swab comprises at least three of said substrates.3. The wound dressing or swab according to claim 1 , characterised in that the wound dressing or swab comprises at least four of said substrates.4. The wound dressing or swab according to claim 1 , characterised in that at least one of said substrates is dispersed or covalently bound in a matrix of a medically acceptable polymer.5. The wound dressing or swab according to claim 4 , wherein said medically acceptable polymer is a hydrogel.6. The wound dressing or swab according to claim 1 , characterised in that at least one of said substrates is bound on a fiber.7. The wound dressing according to claim 6 , wherein said fiber is selected from the group consisting of a fiber of the wound dressing and a fiber of the swab.8. The wound dressing according to claim 1 , characterised in that the at least two substrates are selected from the group consisting of a peptidoglycan claim 1 , N-methoxysuccinyl-ala-ala-pro-val-p-nitroanilide claim 1 , N-methoxysuccinyl-ala-ala-pro-phe p-nitroanilide claim 1 , 3 claim 1 ,3′ claim 1 ,5 claim 1 ,5′-tetramethylbenzidin claim 1 , 2 claim 1 ,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) claim 1 , crystal violet claim 1 ...

TEST SENSOR PACKAGE

A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample. 158-. (canceled)59. A sensor package , comprising:a base portion having at least one conically shaped sensor cavity;at least one test sensor, the at least one test sensor being located in the at least one conically shaped sensor cavity, the at least one test sensor including a formed plastic body and a reagent, the body having a top face with an integral first surface, a bottom face opposed to the first surface, and a sidewall extending from the periphery of the top face, wherein the first surface is configured to accept a fluid sample, and the reagent being disposed on the integral first surface and configured to cause a color change detectable on the second surface when the reagent reacts with an analyte in the fluid sample; anda protective sheet covering the at least one conically shaped sensor cavity.60. The sensor package of claim 59 , wherein the at least one test sensor further comprises a surfactant disposed on the body.61. The sensor package of claim 59 , wherein the at least one conically shaped sensor cavity is a plurality of conically shaped sensor cavities and the at least one test sensor is a plurality of test sensors claim 59 , wherein each one of the plurality of test sensors is located in a respective one of the plurality of conically shaped sensor cavities.62. The sensor package of claim 59 , wherein the formed plastic body is a hollow frustum with a larger open end and a smaller closed end.63. The sensor package of claim 59 , wherein the top face has a raised region substantially ...

TEST ELEMENTS AND METHODS OF PRODUCING THE SAME FOR STUDYING A BODY FLUID SAMPLE

Disclosed herein are methods of producing a test element for studying a body fluid sample. In the methods, a detection layer is covered with a polymeric spreading layer and applied to a support. The spreading layer can be produced by being sprayed onto the detection layer such that the spreading layer has a thickness of at most about 20 μm. Also disclosed are test elements produced by the methods, as well as tape cassettes incorporating such test elements. 1. A method of producing a spreading layer on a test element for testing a body fluid sample , the method comprising the step of:spraying the spreading layer onto a detection layer, wherein the spreading layer comprises at least one polymer, and wherein the detection layer is applied to a support.2. The method of claim 1 , wherein the at least one polymer forming the spreading layer is sprayed together with a liquid that subsequently evaporates.3. The method of claim 2 , wherein the liquid that subsequently evaporates is an organic liquid.4. The method of claim 2 , wherein the liquid that subsequently evaporates is a polar solvent or an aliphatic polar organic solvent.5. The method of claim 2 , wherein the liquid that subsequently evaporates further comprises a hydrophilic substance.6. The method of claim 5 , wherein the hydrophilic substance is a surfactant.7. The method of claim 1 , wherein the spreading layer is a polymer solution or a polymer emulsion.8. The method of claim 1 , wherein the at least one polymer cross-links after being applied by spraying.9. The method of claim 1 , wherein the spraying step uses a pneumatic nozzle.10. The method of claim 1 , wherein the at least one polymer is selected from the group consisting of cellulose claim 1 , polyethylene glycol claim 1 , polyvinylalcohol claim 1 , polyolefin claim 1 , polyurethane claim 1 , polyamide claim 1 , polyimide claim 1 , polyacrylate claim 1 , polycarbonate claim 1 , polyester claim 1 , polyether claim 1 , polyvinylether claim 1 , ...

METHOD AND TEST MIXTURES FOR DETECTING THE PRESENCE OR ABSENCE OF TARGET MICROBES IN A TEST SAMPLE

A method of and test mixture for detecting the presence or absence of a target microbe in a sample is provided. The method includes the steps of: a) providing a test mixture that includes micro particles, a substrate in an amount that is sufficient to support log phase growth of the target microbe until a detectable characteristic signal is produced in the test mixture and sample admixture, and an amount of vitamin, amino acid, element and salt ingredients; b) combining the powdered test mixture and sample to form the admixture; and c) detecting the presence or absence of target microbes in the sample based on the presence or absence of the detectable characteristic. 1. A target microbe-specific test mixture for detecting the presence or absence of a target microbe in an environmental or biological sample , the test mixture comprising:micro particles in an amount that is effective to accelerate the formation of microbial biofilms in an admixture of the test mixture and the sample;a metabolizable substrate in an amount that is sufficient to support log phase growth of the target microbe until a detectable characteristic signal is produced in the test mixture and sample admixture, which metabolize substrate is adapted to produce the detectable characteristic signal when metabolized by the target microbe;an amount of vitamin, amino acid, element and salt ingredients, which amount of ingredients is operable to allow viability of the target microbe in the presence of the metabolizable substrate and to aid the target microbe through lag phase and into log phase reproduction of the target microbe in the sample; andwherein the test mixture is incompetent of supporting continued growth of any viable non-target microbes in the admixture in an amount that would interfere with the detection of the target microbe.2. The test mixture of claim 1 , wherein the micro particles comprise a static material within the sample/test mixture admixture.3. The test mixture of claim 2 , ...

KITS AND METHODS FOR CYANIDE DETECTION

Provided herein are compositions, kits, methods and devices for cyanide detection, particularly for cyanide detection in biological samples such as whole blood. The method comprises (1) contacting a sample with a cobinamide conjugate comprising a cobinamide moiety and a carrier; and (2) measuring the absorbance of light by the cobinamide conjugate. The present disclosure provides field-deployable cyanide detection methods, compositions, kits and devices, which provide rapid, accurate readout at the point of contact. Further provided herein is a method for determining exposure of a subject to cyanide. 1. A method for detecting cyanide in a sample , comprising:contacting a sample with a cobinamide conjugate comprising a cobinamide moiety and a carrier; andmeasuring the absorbance of light by the cobinamide conjugate.2. The method of claim 1 , wherein the carrier is a molecule or a surface.3. The method of claim 2 , wherein the cobinamide moiety is conjugated to the carrier covalently claim 2 , either directly or indirectly.4. The method of claim 1 , further comprising comparing the absorbance of light by the cobinamide conjugate with a control feature.5. The method of claim 1 , wherein the absorbance of light is measured at a visible wavelength of about 400 nm to about 700 nm.6. The method of claim 1 , wherein the absorbance of light is measured at an invisible wavelength of about 250 nm to about 400 nm.7. The method of claim 1 , wherein the sample is contacted with the cobinamide conjugate without pre-treatment claim 1 , wherein the sample is a biological sample.8. The method of claim 7 , wherein the biological sample is blood.9. The method of claim 8 , wherein the assay time of the method is less than five minutes.10. The method of claim 8 , wherein the amount of cyanide in the sample is from about 7.5 μM to about 1000 μM.11. A kit for detecting cyanide in a sample claim 8 , comprising a cobinamide conjugate claim 8 , said cobinamide conjugate comprising a ...

COLORIMETRIC GELATINASE ASSAY

The present invention is drawn toward a lateral-flow, colorimetric, gelatinase assay including a sample pad, a reagent pad, a membrane, and an absorbent pad, in that order, wherein the reagent pad has therein a dried form of gelatin-coated nanoparticles in a salt and sugar matrix, and wherein the membrane portion has a test stripe and a control stripe, such that the test stripe is a solution of electrolyte evaporated into a layer, and the control stripe is a solution of anti-gelatin antibody evaporated into a layer. The present invention is also drawn toward a method of detecting one or more gelatinases in a sample fluid using the assay, and methods of determining treatment for wound healing, cancer, ocular rosacea, periodontal disease and equine arthritis using the assay. 1. A lateral-flow , colorimetric , gelatinase assay comprising a sample pad , a reagent pad , a membrane , and an absorbent pad , in that order , wherein:the reagent pad comprises therein a dried form of gelatin-coated nanoparticles in a salt and sugar matrix, andthe membrane comprises a test stripe and a control stripe, wherein the test stripe comprises a solution of electrolyte evaporated into a layer, and the control stripe comprises a solution of anti-gelatin antibody evaporated into a layer.2. The assay according to claim 1 , wherein one or more of the sample pad claim 1 , the reagent pad and the absorbent pad are a woven mesh or a cellulose filter.3. The assay according to claim 1 , wherein one or more of the sample pad claim 1 , the reagent pad and the absorbent pad are porous paper.4. The assay according to claim 1 , wherein the nanoparticles are colloidal gold nanoparticles or colloidal silver nanoparticles.5. The assay according to claim 1 , wherein the membrane is a porous claim 1 , synthetic claim 1 , polymeric membrane.6. The assay according to claim 4 , wherein the membrane is selected from the group consisting of nitrocellulose claim 4 , polyvinylidene fluoride claim 4 , nylon and ...

RAPID DETECTION OF CEREBROSPINAL FLUID, METHODS AND SYSTEMS THEREFORE

Methods and systems are disclosed for rapid detection of cerebrospinal fluid (CSF) in a sample. In some embodiments, the methods comprise depleting a biological sample of beta-1 transferrin by contacting the sample with a sialic acid-specific lectin bound to a solid support, followed by subjecting the beta-1 transferrin-depleted sample to a lateral flow immunoassay. The methods can be used to detect CSF comprised by a sample in under one hour. Furthermore, the methods can detect CSF in a biological sample such as a plasma sample of a volume as small as about 10 μl. 1. A method for determining presence , absence or quantity of cerebral spinal fluid in a biological sample , the method comprising: a) forming a beta-1 transferrin-depleted sample by contacting a biological sample with lectin coated on a solid support for a time , wherein the lectin is a sialic acid-specific lectin; b) subjecting the beta-1 transferrin-depleted sample to a lateral flow immunoassay , wherein the immunoassay comprises: i) applying the transferrin-depleted sample to a lateral flow immunoassay section , wherein the section comprises a test surface comprising a first zone comprising a first conjugate comprising a first antibody directed against transferrin and colloidal gold particles , and a second zone comprising a second antibody directed against transferrin , wherein the second antibody is immobilized on the test surface in the second zone; ii) flowing the beta-1 transferrin-depleted sample on the test surface by capillary action , wherein the beta-1 transferrin-depleted sample contacts the first conjugate in the first zone , and wherein the transferrin , if any , comprised by the beta-1 transferrin-depleted sample forms a first complex comprising the transferrin comprised by the beta-1 transferrin-depleted sample , and the first conjugate; iii) further flowing the beta-1 transferrin-depleted sample across a second zone , wherein the first complex , if present , contacts a second antibody ...

ELECTRONIC DEVICE FOR ANALYZING AQUEOUS SOLUTIONS

An electronic device for analyzing an aqueous solution may comprise a housing, one or more measurement circuits and a control circuit all arranged inside the housing. The housing may be configured to receive a test element. The one or more measurement circuits may be configured to produce one or more corresponding sets of measurement signals relating to an aqueous solution received on the test element. The control circuit may include a memory having instructions stored therein that are executable by the control circuit to process the one or more sets of measurement signals to determine one or more corresponding characteristics of the aqueous solution. 1. A device for analyzing a plurality of characteristics of an aqueous solution , comprising:a portable hand-held housing having an interior;a test element receiving port configured to receive a wetted test element;circuitry in the housing for selectively generating radiation for interrogating a plurality of different portions of a wetted test element when placed within the test element receiving port, for receiving radiation reflected from the test element, and for generating a display responsive to the reflected radiation and indicative of the plurality of different characteristics of the aqueous solution; and,wherein the test element receiving port is proximate portions of the circuitry generating the radiation and receiving the reflected radiation.2. The device of claim 1 , wherein the circuitry is configured to execute instructions in response to measurement signals generated upon detection of reflected radiation to determine the different characteristics of the aqueous solution in response to the reflected radiation received by the radiation detection circuits.3. The device of claim 1 , further comprising a display on the housing and the display being associated with the circuitry and displaying an indication responsive to the determined different characteristic of the aqueous solution.4. The device of claim 1 , ...

ELECTRONIC DEVICE FOR ANALYZING AQUEOUS SOLUTIONS

An electronic device for analyzing an aqueous solution may comprise a housing, one or more measurement circuits and a control circuit all arranged inside the housing. The housing may be configured to receive a test element. The one or more measurement circuits may be configured to produce one or more corresponding sets of measurement signals relating to an aqueous solution received on the test element. The control circuit may include a memory having instructions stored therein that are executable by the control circuit to process the one or more sets of measurement signals to determine one or more corresponding characteristics of the aqueous solution. 1. A test element for determining a characteristic of an aqueous solution , comprising:an opaque substrate;a first side of the opaque substrate comprising a non-reflective surface; and,a test pad on the substrate comprising a reagent responsive in color to a characteristic of an aqueous solution.2. The test element of claim 1 , wherein the first side of the substrate is black in color.3. The test element of claim 1 , wherein the first side of the substrate presents a dark color to avoid optical color noise when the test element is illuminated by the source of radiation.4. The test element of claim 1 , further comprising a plurality of test pads affixed to the opaque substrate claim 1 , each test pad comprising a respective reagent responsive in color to a respective different characteristic of the aqueous solution.5. The test element of claim 1 , wherein the plurality of different characteristics of the aqueous solution include one or more of chlorine concentration claim 1 , bromine concentration claim 1 , pH level claim 1 , alkalinity concentration claim 1 , ammonia concentration claim 1 , nitrite concentration claim 1 , nitrate concentration claim 1 , solution hardness claim 1 , peracetic acid concentration claim 1 , peroxide concentration and chloramine concentration.6. A test element comprising:a light-blocking ...

METHOD FOR PERFORMING A RAPID TEST

The present invention relates to a method for performing a quantitative or qualitative analysis by a two-phase rapid test. In the method a signal reagent is placed into a container made of non-absorbing material, the container being located separate from the rapid test device. The signal reagent is reacted with the analyte(s) present in a test sample by adding the liquid test sample into the container. A reaction solution is obtained, which is then contacted with the rapid test device, wherein a detectable signal is developed. Subsequently, the development of the signal is monitored and read continuously. 1. A method for performing a two-phase rapid test , comprising the steps ofa) placing a predetermined amount of a signal reagent into a container made of non-absorbing material, wherein the container is located separate from the rapid test device,b) reacting the signal reagent with the analyte(s) present in a test sample by adding a liquid test sample into the container, to obtain a reaction solution,c) contacting said reaction solution with the rapid test device, wherein a detectable signal is developed by means of the signal reagent,d) continuously monitoring the development of the signal in the detection zone of the rapid test device by real-time reading of the signal using an apparatus which enables kinetic measurement.2. The method according to claim 1 , wherein said signal reagent is in the container in dry form claim 1 , being solubilised by means of the test sample.3. The method according to claim 1 , wherein the material of the container is polypropylene claim 1 , polyethylene or polystyrene.4. The method according to claim 1 , wherein the analyte is selected from the group consisting of nucleic acids claim 1 , lipids claim 1 , carbohydrates claim 1 , vitamins claim 1 , proteins claim 1 , polypeptides claim 1 , bacteria and viruses claim 1 , and parts or mixtures thereof claim 1 , and antibodies claim 1 , antigens claim 1 , metabolic products and metabolic ...

METHOD OF DETERMINING A CONCENTRATION OF NITRATE

A method of determining a concentration of nitrate includes mixing an acid with a first mixture comprising an aldehyde, a chloride and at least one of a nitrate sample and distilled water so as to obtain a second mixture. The second mixture is reacted with a phenol so as to develop a color in a third mixture after a reaction time. The concentration of nitrate is determined colorimetrically with the third mixture. 116-. (canceled)17. A method of determining a concentration of nitrate , the method comprising:mixing an acid with a first mixture comprising an aldehyde, a chloride and at least one of a nitrate sample and distilled water so as to obtain a second mixture;reacting a phenol with the second mixture so as to develop a color in a third mixture after a reaction time; anddetermining the concentration of nitrate colorimetrically with the third mixture.18. The method as recited in claim 17 , wherein:the first mixture is obtained by mixing a first solution containing the aldehyde with a second solution containing the chloride to obtain an aldehyde-chloride solution and adding a third solution containing the at least one of a nitrate sample and distilled water to the aldehyde-chloride solution to obtain a fourth solution as the first mixture,the second mixture is obtained by mixing the acid with the fourth solution so as to obtain a fifth solution as the second mixture, andthe third mixture is obtained by reacting a sixth solution containing the phenol with the fifth solution.19. The method as recited in claim 17 , wherein the aldehyde is formaldehyde.20. The method as recited in claim 19 , wherein the formaldehyde is provided as at least one of a solid claim 19 , as a liquid/solution claim 19 , as a gas claim 19 , as a compound which will produce formaldehyde when reacting with the acid and the phenol claim 19 , as a formaldehyde-releasing plastic claim 19 , and as a formaldehyde-releasing antimicrobial chemical compound.21. The method as recited in claim 20 , ...

Aquatic Environment Water-Quality Monitor Having A Submersible Chemical Indicator Wheel

A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities. 1. A water-quality monitoring system for monitoring quality of water in an aquatic environment , comprising: a holder having a rotational axis; and', 'a plurality of chemical indicators fixedly supported by said holder, wherein said plurality of chemical indicators are designed and configured to undergo optically detectable changes in response to changes in levels of corresponding respective differing constituents of the water; and, 'a chemical indicator wheel designed and configured to be submerged in the water of the aquatic environment during use, said chemical indicator wheel including an optical reader designed and configured to acquire optical readings of each of said plurality of indicators; and', 'a drive system designed and configured to drive said chemical indicator wheel to at least one reading position for each of said plurality of chemical indicators, wherein said optical reader can take a reading., 'a monitoring unit that includes2. A water-quality monitoring system according to claim 1 , wherein said holder is discoidal in shape.3. A water-quality monitoring system according to claim 1 , wherein each of said plurality of ...

MANIPULATION OF FLUIDS IN THREE-DIMENSIONAL POROUS PHOTONIC STRUCTURES WITH PATTERNED SURFACE PROPERTIES

A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated. 1. A structure for providing an indication of the presence of one or more indicator materials , the structure comprising:a porous three-dimensional photonic structure comprising a first region and a second region; whereinsaid first region comprises a first functional group on at least some of the interior surfaces of the porous three-dimensional photonic structure;said second region comprises a second functional group on at least some of the interior surfaces of the porous three-dimensional photonic structure; andthe first functional group attracts a first indicator material differently than the second functional group.2. The structure of claim 1 , wherein said first indicator material is a fluid.3. The structure of claim 1 , wherein said first region in the absence of said first indicator material has a substantially similar visible appearance to the visible appearance of said second region.4. The structure of claim 1 , wherein said first region comprises said first indicator material filled in at least some of the pores of said first region claim 1 , and said first region has a different reflectance spectrum than the reflectance spectrum of said second region.5. The structure of claim 1 , wherein the first surface property includes wettability claim 1 , hydrophobicity claim 1 , hydrophilicity claim 1 , lyophobicity claim 1 , or lyophilicity.6. The structure of claim 1 , wherein the second region attracts a second ...

ULTRA-HIGH-SENSITIVE ASSAY OF PROTEIN AND NUCLEIC ACID AND KIT, AND NOVEL ENZYME SUBSTRATE

Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically. 3. The method according to claim 1 , whereinthe enzyme is alkaline phosphatase, and{'sup': 1', '2', '1', '2, 'sub': 1-6', '1-6, 'X represents a phosphate group, Yand Yrepresent together a methylene group, or Yrepresents hydrogen, and Yrepresents a Calkoxy group, or a Calkyl group in the androsterone derivative represented by the formula (1).'}4. The method according to claim 1 , whereinthe enzyme is glucosidase, galactosidase, fructosidase or mannosidase, and{'sup': 1', '2', '1', '2, 'sub': 1-6', '1-6, 'X represents a sugar moiety, the sugar moiety represents one selected from the group consisting of glucose, galactose, fructose and mannose, and Yand Yrepresent together a methylene group, or Yrepresents hydrogen, and Yrepresents a Calkoxy group, or a Calkyl group in the androsterone derivative represented by the formula (1).'}5. The method according to claim 1 , whereinthe enzyme is peroxidase, and{'sub': 1-6', '1-6', '1-6, 'sup': 1', '2', '1', '2, 'X represents —O—CO—R (provided that R represents a Calkyl group or a phenyl group), and Yand Yrepresent together a methylene group, or Yrepresents hydrogen, and Yrepresents a Calkoxy group, or a Calkyl group in the androsterone derivative represented by the formula (1).'}13. The androsterone derivative according to claim 12 , wherein the definitions of X claim 12 , Yand Yare those of (A) X represents a phosphate group claim 12 , and Yand Yrepresent ...

Embedded Indicator Dye Monitoring System and Method For An Aquatic Environment

An aquatic environment monitoring system that includes chemical indicators that are dyes immobilized in an immobilizing medium, such as a hydrogel, and supported on a holder such that an optical reader may be used to illuminate the indicator dyes. The chemical indicator dyes include chemical indicator dyes that are sensitive for detecting calcium, magnesium, and carbon dioxide present in the aquatic environment. 1. An aquatic environment monitoring apparatus comprising: a first chemical indicator dye sensitive for detecting calcium in the aquatic environment, the first chemical indicator dye immobilized in a first immobilizing medium;', 'a second chemical indicator dye sensitive for detecting magnesium in the aquatic environment, the second chemical indicator dye immobilized in a second immobilizing medium;', 'a third chemical indicator dye sensitive for detecting carbon dioxide in the aquatic environment, the third chemical indicator dye immobilized in a third immobilizing medium;, 'a plurality of immobilized chemical indicators wherein the chemical indicators includea chemical indicator holder supporting the first, second, and third chemical indicator dyes;one or more optical readers configured to illuminate the first, second, and third chemical indicator dyes.2. An aquatic environment monitoring apparatus according to claim 1 , further comprising a dosing calculator configured to use an amount of calcium claim 1 , an amount of magnesium claim 1 , and/or an amount of carbon dioxide present in the aquatic environment in a decision for adding a corresponding one of calcium claim 1 , magnesium claim 1 , and/or a source of carbonate to the aquatic environment claim 1 , the amount of calcium claim 1 , magnesium claim 1 , and/or carbonate being determined via the one or more optical readers illuminating the first claim 1 , second claim 1 , and/or third chemical indicator dyes respectively.3. An aquatic environment monitoring apparatus according to claim 2 , wherein the ...

Monitoring of Photo-Aging of Light-Based Chemical Indicators Using Illumination-Brightness Differential Scheme, and Systems, Methods, Apparatuses, and Software Relating Thereto

Photo-aging monitoring of light-based chemical indicators that experience performance degradation as the cumulative amount of light exposure from measurement and/or reference illumination increases from usage. Differing regions on a chemical indicator are illuminated with measurement illumination light of differing exposures, for example, higher brightness, longer exposure times, or both. Readings from the differing regions are compared with known aging information for the chemical indicator at issue to determine a confidence factor for the measurements. The confidence factor can be used to control various actions relating to measurements acquired from the chemical indicators, such as compensating measurement readings for photo-aging, assigning confidence levels to measurement readings, and issuing alerts to users when photo-aging exceeds one or more predetermined thresholds. 1. A method of monitoring photo-aging of a chemical indicator in an aquatic-environment monitoring/measuring system , comprising:taking, over a first period of time and using an optical reading system, a plurality of first optical readings from a first illumination spot on the chemical indicator, wherein each of the first optical readings is based on illuminating the first illumination spot with measurement light that creates a first exposure value;taking, over a second period of time and using the optical reading system, a plurality of second optical readings from a second illumination spot on the chemical indicator, wherein each of the second optical readings is based on illuminating the second illumination spot with measurement light that creates a second exposure value that is different from the first value so as to create an exposure differential;generating exposure-differential data as a function of the exposure differential; andusing the exposure-differential data to determine whether or not to take a remedial action relative to measurements acquired from the chemical indicator by the ...

Method to identify chemical compounds using colorimetric spot tests

A method to identify a compound of interest includes the step of subjecting a sample to a plurality of colorimetric spot tests to yield a plurality of resultant test colors. The resultant test colors are compared with reference colors to define a set of sample reference colors. Indexed reference color sets indexed for the compound of interest are provided. The indexed reference color sets are searched with one or more of the sample reference colors for a match with the set of sample reference colors. The identity of the sample as the compound of interest is then determined. A device and a system to identify compounds of interest are also disclosed.

METHOD OF DETECTING PANCREATIC DISEASE AND PANCREAS TESTING KIT

A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration of S100P in at least one of a pancreatic juice and a body fluid containing pancreatic juice collected from a test subject by immunochromatography. Additionally provided is a pancreas testing kit including an immunochromatography device that holds an anti-S100P antibody and a collection vessel that retains a protease inhibitor that inhibits an activity of a protease contained in the pancreatic juice. 1. A method of detecting pancreatic disease , comprising:detecting a concentration of S100P in at least one of a pancreatic juice and a body fluid containing pancreatic juice collected from a test subject by immunochromatography.2. The method of detecting pancreatic disease according to claim 1 , wherein the pancreatic juice is collected from a pancreatic duct.3. The method of detecting pancreatic disease according to claim 1 , wherein the body fluid containing pancreatic juice is collected from a duodenum.4. The method of detecting pancreatic disease according to claim 3 , wherein the body fluid containing pancreatic juice is a duodenal juice.5. The method of detecting pancreatic disease according to claim 1 , wherein the pancreatic juice and the body fluid containing pancreatic juice are obtained without administering a stimulant of pancreatic juice secretion.6. The method of detecting pancreatic disease according to claim 1 , wherein the pancreatic juice and the body fluid containing pancreatic juice are a pancreatic juice secreted due to administration of a stimulant of pancreatic juice secretion and a body fluid containing this pancreatic juice.7. The method of detecting pancreatic disease according to claim 1 , wherein the at least one of the pancreatic juice and the body fluid containing pancreatic juice collected by a collection vessel are used claim 1 , the collection ...

SPECTROSCOPIC FINGER-PRINTING OF RAW MATERIALS

The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation. 1. A method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation comprising the following steps:a) providing spectra of different batches of a first component obtained with a first spectroscopic method selected from NIR spectroscopy and MRI spectroscopy and spectra of a second component obtained with 2D-fluorescence spectroscopy and the cultivation supernatant yield of the protein of interest obtained in a cultivation using combinations of these different batches of the first and the second component,b) identifying a relation of fused spectra of the two different spectroscopic techniques after computing spectra PCA scores with the yield of the cultivation,c) providing a spectrum of a further batch of the first component obtained with the first spectroscopic method and a spectrum of a further batch of the second component obtained with the second spectroscopic method,d) selecting the combination of the provided first component and the provided second component if the predicted cultivation supernatant yield based on the relation of fused spectra after computing spectra PCA scores identified in b) is within +/−10% of the mean yield provided in a).2. canceled3. The method according to claim 1 , characterized in that the identifying is by principal component analysis.4. The method according to claim 3 , characterized in that the principal component analysis is an unfolded principal component analysis.5. The method according to claim 4 , characterized in that the unfolding preserves the information of the first mode (sample).6. The method according to claim 4 , claim 4 , and claim 4 ...

Analytical Aid

A process for producing an analytical aid for the detection of at least one analyte in a sample, such as a body fluid. The analytical aid includes at least one housing and at least one test element including at least one test chemistry. The process includes the following steps: providing the test element; and producing at least one housing part of the housing at least one shaping process, during which the test element is connected to the housing part. 1. A process for producing an analytical aid for the detection of at least one analyte in a sample , wherein the analytical aid comprises at least one housing and at least one test element comprising at least one test chemistry , wherein the process comprises the following steps:a) providing the test element comprising the test chemistry; and 'wherein, in step b), the test element is connected to the housing part such that at least one surface of the test chemistry as test field area for application of the sample remains uncovered by a housing material of the housing part, wherein the housing is configured such that at least one observation window is produced in the housing, wherein the test field area is optically monitorable through the observation window of the housing, wherein the process is carried out such that the housing forms at least one chamber, wherein the test field area faces an interior space of the chamber.', 'b) producing at least one housing part of the housing by means of at least one shaping process, during which the test element comprising the test chemistry is connected to the housing part,'}2. The process according to claim 1 , wherein the shaping process comprises at least one casting process.3. The process according to claim 1 , wherein the shaping process comprises at least one plastics shaping process claim 1 , wherein the plastics shaping process is selected from a back injection molding and an insert molding.4. The process according to claim 1 , wherein claim 1 , in step b) claim 1 , at ...

DUAL-FUNCTION HEAT INDICATOR AND METHOD OF MANUFACTURE

A dual-function heat indicator for monitoring two or more modes of heat exposure is described. A manufacturing process for the dual-function heat indicator is also described. Dual-function heat indicators as described may be useful for monitoring the exposure of host products, with which the dual-function heat indicators may be associated, to cumulative ambient heat exposure and to a peak ambient heat exposure, and for other purposes. 1. A dual-function heat indicator for monitoring cumulative ambient heat exposure and peak ambient heat exposure , the dual-function heat indicator comprising:a substrate;a cumulative exposure indicator supported by the substrate in a viewable, layered configuration, the cumulative exposure indicator being color-changeable in response to cumulative ambient heat exposure; anda peak exposure indicator supported by the substrate in a viewable, layered configuration, the peak exposure indicator comprising a first reactant, a second reactant and a meltable solid, the first reactant being chemically co-reactable with the second reactant to provide a color change, the meltable solid physically separating the first reactant from the second reactant, and the color-changing chemical reaction being induced in response to an ambient heat exposure peak temperature exceeding the melting point of the meltable solid;wherein the dual-function heat indicator indicates at least one of cumulative ambient heat exposure and peak ambient heat exposure by changing color.2. A dual-function heat indicator according to claim 1 , comprising a viewable active area wherein the cumulative exposure indicator and the peak exposure indicator are viewable in the active area with the optical densities of the viewed indicators combined.3. A dual-function heat indicator according to claim 1 , wherein the peak exposure indicator comprises a peak indicator layer of the dual-function heat indicator and the first reactant and the second reactant are particulate and are ...

ANALYTICAL DEVICES FOR DETECTION OF LOW-QUALITY PHARMACEUTICALS

A multilayer Paper Analytical Device (PAD) is provided for detection of at least two chemical components indicative of a low quality pharmaceutical or dietary supplement product. A method for detection of at least two chemical components indicative of a low quality pharmaceutical or dietary supplement product is also provided that employs a multilayer PAD. A kit is provided for detection of at least two chemical components indicative of a low quality pharmaceutical or dietary supplement product that includes a multilayer PAD and instructions for using the kit. 1. A multilayer Paper Analytical Device for detection of at least two chemical components indicative of a low quality pharmaceutical product or dietary supplement , comprising:one or more assay regions in communication with a non-chemically interfering binder agent disposed adjacent at least one hydrophobic layer; andone or more vessels each having a wall that houses one or more reagents in registry with at least one assay region for which testing for a chemical component is desired;wherein rupture of a vessel wall establishes communication between a corresponding assay region and the one or more reagents released by the ruptured vessel wall.2. The device of claim 1 , wherein the at least one vessel is fabricated from a rupturable material.3. The device of claim 1 , wherein the one or more vessels are integral with at least assay region.4. The device of claim 1 , wherein the one or more vessels when ruptured are in fluid communication with the assay region.5. The device of claim 1 , wherein at least one or more of an information identification zone and a color calibration zone is provided on the Paper Analytic Device.6. The device of claim 1 , further comprising at least one electronically readable information zone that claim 1 , after activation of the device claim 1 , provides color information necessary for detection of the at least two chemical components claim 1 , and wherein the least one electronically ...

CASE FOR SPECIMEN ANALYZING KIT, KIT FOR SPECIMEN ANALYZING, SPECIMEN ANALYSIS APPARATUS AND CONTROL METHOD OF SPECIMEN ANALYSIS APPARATUS

Provided is a case for specimen analyzing kit. The case includes a cover unit comprising a put-in part through which a specimen is putted and a result exposing part exposing a reaction result between the specimen and a reaction pad to the outside, a support unit coupled to the cover unit to define a predetermined inner space, and a plurality of put-in holes passing through the put-in part to introduce the specimen into the inner space. 1. A case for specimen analyzing kit , the case comprising:a cover unit comprising a put-in part through which a specimen is putted and a result exposing part exposing a reaction result between the specimen and a reaction pad to the outside;a support unit coupled to the cover unit to define a predetermined inner space; anda plurality of put-in holes passing through the put-in part to introduce the specimen into the inner space.2. The case of claim 1 , wherein the put-in part is recessed from a top surface of the cover unit to protrude toward the inner space claim 1 , andthe put-in holes are defined in a bottom surface of the put-in part.3. The case of claim 1 , wherein the support unit comprises at least one partition wall partitioning a region corresponding to the put-in holes to prevent the specimens introduced into the inner space through the plurality of put-in holes from interfering with each other.4. The case of claim 3 , wherein the partition wall protrudes from a bottom surface of the support unit toward the inner space and is disposed between the plurality of put-in holes.5. The case of claim 3 , wherein the support unit comprises at least one fixing wall disposed outside the partition wall to fix an end of the reaction pad to the support unit.6. The case of claim 5 , wherein the support unit comprises a fixing corresponding wall corresponding to the fixing wall to fix the other end of the reaction pad.7. The case of claim 3 , wherein the support unit comprises a partition corresponding wall corresponding to the partition ...

RAPID DETECTION OF UREA IN ADULTERATED MILK USING THREAD BASED MICROFLUIDIC SYSTEM

A system for detecting an adulterant in a sample of milk. One or more drops of milk are added to a first location of a system and the presence or absence of the adulterant is detected in a second location of the system using a material treated with a detection reagent. 1. A system comprising a first location , a second location and at least one cotton thread attached at a first end to the first location and at a second end to the second location.2. The system according to claim 1 , wherein the first location is a reservoir.3. The system according to claim 1 , wherein the second location is used for detection.4. The system according to claim 1 , wherein a plurality of cotton threads are used.5. The system according to claim 4 , wherein the threads are braided.6. The system according to claim 3 , wherein the second location comprises a material treated with a detection reagent.7. The system according to claim 6 , wherein the detection reagent is Ehrlich's reagent.8. The system according to claim 6 , wherein the material is paper.9. A method of detecting an adulterant in a sample of milk comprising the steps of loading one or more drops of milk in a first location of the system of and detecting the presence of the adulterant in the second location of the system of wherein a material treated with a detection reagent is present in the second location.10. The method of claim 9 , wherein the material is treated with a polymer gel and dried before being treated with a detection reagent.11. The method of claim 9 , wherein the milk is synthetic milk.12. The method of claim 9 , wherein the material is paper.13. The method of claim 9 , wherein the adulterant is urea.14. The method of claim 9 , wherein the detecting reagent is Ehrlich's reagent.15. The method of claim 9 , wherein the adulterant is one or more of urea claim 9 , glucose claim 9 , sodium hydroxide (NaOH) claim 9 , potassium hydroxide (KOH) claim 9 , bleaching agents claim 9 , and salicylic acid. The present ...

PROTEIN ASSAY APPARATUS

A protein assay apparatus includes at least one light-emitting unit for generating a first light, a second light or a third light for BCA protein assay, Bradford protein assay or Lowry protein assay, and at least one light-sensing unit for sensing the absorbed light passed through the test sample to calculate the concentration of protein in the test sample. This design shortens the protein examination time and greatly reduces the protein examination cost. 1. A protein assay apparatus , comprising:a plurality of light-emitting units adapted to respectively emit a first light, a second light and a third light onto a test sample, wherein said first light is a green light, said second light is a yellow light, and said third light is a red light;at least one light-sensing unit adapted to receive a first absorbed light, a second absorbed light or a third absorbed light and to measure the intensity of said first absorbed light, said second absorbed light or said third absorbed light, wherein said test sample absorbs part of said first light, said second light or said third light to generate said first absorbed light, said second absorbed light or said third absorbed light; andan arithmetic logic unit electrically connected to said light-sensing units and adapted to convert the intensity of said first absorbed light, said second absorbed light or said third absorbed light being measured by said light-sensing units into a value indicative of the concentration of protein in said test sample2. The protein assay apparatus as claimed in claim 1 , wherein the number of said light-emitting units is 3 and these three light-emitting units are adapted to emit said first light claim 1 , said second light and said third light respectively claim 1 , and one of these three light-emitting units is selected to emit one of said first light claim 1 , said second light and said third light at one time point.3. The protein assay apparatus as claimed in claim 2 , wherein said first light has a ...

URINE GENDER TEST KIT

A kit and methods for determining the gender of an unborn fetus. The kit comprises a container holding a solid composition therein, the solid composition including a basic salt and a transition metal separated by a filler and in which an atmosphere in the container is substantially free of water. 1. A kit for determining the gender of an unborn fetus , comprising:a container holding a solid composition therein, said solid composition including a basic salt and a transition metal separated by a filler, wherein an atmosphere in said container is substantially free of water.2. The kit of claim 1 , wherein said atmosphere is composed of dry nitrogen or dry air.3. The kit of claim 1 , wherein an opening of said container is covered with an air-tight seal.4. The kit of claim 1 , wherein an opening of said container is covered with a metal foil seal that is adhesively coupled to said opening.5. The kit of claim 1 , wherein said basic salt and a transition metal form separate layers in said contain.6. The kit of claim 1 , wherein said basic salt and a transition metal form separate layers in said container and a third layer of a neutral filler separating said layer of said basic salt from said layer of said transition metal.7. The kit of claim 1 , wherein said basic salt includes a water-soluble alkali metal hydroxide.8. The kit of claim 1 , wherein said transition metal includes aluminum.9. The kit of claim 1 , wherein said neutral filler includes a neutral salt.10. The kit of claim 1 , wherein said neutral filler includes a water-soluble polymer.11. The kit of claim 1 , wherein said solid composition further includes an indicator configured to enhance a color change in a solution resulting from mixing said solid composition with testosterone-containing urine.12. The kit of claim 1 , further including indicator strips that each have a colored surface that matches a color of one of either a solution resulting from mixing said solid composition with urine from a female that ...

MOBILE APP FOR CHEMICAL DETECTION

The present invention incorporates the camera from a mobile device (phone, iPad, etc.) to capture an image from a chemical test kit and process the image to provide chemical information. A simple user interface enables the automatic evaluation of the image, data entry, gps info, and maintain records from previous analyses. 1. A mobile app for providing chemical information , comprising the steps of:performing a chemical test producing results,capturing an image of said results, andprocessing said image to provide the chemical information.2. The mobile app for providing chemical information of wherein said step of performing a chemical test producing results is a swipe test for detecting explosives and wherein said results are colorimetric results.3. The mobile app for providing chemical information of wherein said step of performing a chemical test producing results is a spray test for detecting explosives and wherein said results are colorimetric results.4. The mobile app for providing chemical information of wherein said step of performing a chemical test producing results is a thin layer chromatography test and wherein said results are separation results.5. The mobile app for providing chemical information of wherein said step of performing a chemical test producing results is an electrophoresis test and wherein said results are gel results.6. The mobile app for providing chemical information of wherein said step of performing a chemical test producing results is a DNA analysis test and wherein said results are separation results.7. The mobile app for providing chemical information of further comprising the step of providing documentation of the test results.8. The mobile app for providing chemical information of further comprising the step of storing documentation of the test results including time of the test and location of the test.9. A mobile app for determining the presence of a specific chemical claim 1 , comprising the steps of:performing a test to ...

Point-Of-Care, Medical Condition Screening Kit

A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents (), (b) a substrate () configured to: i) receive one of the reagents and react with it so as to cause it to acquire a first characteristic color, and, ii) upon the addition of the individual's bodily fluid to the substrate, acquire, as a result of the formulation of each of the reagents, a second, dichotomous characteristic color when the individual has a specific one of the various, medical conditions. This kit also includes: (c) a plurality of containers () having indicia () that are reflective of the reagent within the container and which of the various medical conditions is being screened for with the use of the container and the characteristic first and second colors which are indicative of the individual having a screened for medical condition, and (d) one of the reagents being a protein reagent that includes appropriate quantities of: water, isopropyl alcohol, citric acid monohydrate, sodium citrate iribasic monohydrate, tetrabromophenol blue and tartrazine. 11. A point-of-care screening kit () for use by heath care workers to make custom test strips to screen the bodily fluids of an individual for various , medical conditions , said kit comprising:{'b': '12', 'a reagent (),'}{'b': 18', '18', '12, 'i': 'a', 'a substrate () having an outer surface () that has a configuration adapted to: a) receive said reagent () and react with said reagent so as to cause said substrate outer surface to acquire a first characteristic color that is indicative of one of said medical conditions for which said screening is being undertaken, and, b) upon the addition of a specified quantity of said bodily fluid of said individual to a portion of said substrate containing said reagent, acquire a second characteristic color that is indicative of said individual having said ...

DETECTION KIT

A detection kit comprises a plurality of swabs, each of the plurality of swabs having the form of a stick, being bundled together in a single test kit for detection of a plurality of chemical compounds. A user opens a detection kit, swabs a surface or surfaces with the bundled sticks, collecting chemical constituents to be tested on detection surfaces of each of the plurality of sticks. Liquids, mists, vapors and powders may be tested in one method, utilizing one or more dry reagents on the detection surfaces. The sticks may comprise a volume of fluid, releasably contained within the sticks, such that when activated, a fluid, such as a reagent or solvent, is wicked by a wicking tip to the detection surface of the stick. For example, a mechanism is provided that is capable of breaking a vial or ampoule containing the fluid, when activated by a twisting motion or compression. Adhesive may be present on one or more of the detection surfaces. A transparent reaction chamber may be provided by a transparent cover or cap. 1. A detection kit for detecting a target compound or target compounds comprises:a plurality of sticks, each stick comprising: an outer sheath, a wicking tip, a detection surface and a volume of a fluid;an outer housing containing the plurality of sticks;an activating mechanism; and wherein the detection surface of each of the plurality of sticks is disposed on the wicking tip arranged such that the wicking tip is capable of directing the fluid to the detection surface by wicking of the fluid from the volume, when the fluid is released by activating the activation mechanism;', 'wherein the fluid comprises a solvent, a reagent or a combination of a solvent and a reagent;', 'wherein the volume of the fluid is contained within the outer sheath, such that when the fluid is released from the volume, the outer sheath contains the fluid within the stick, whereby the fluid is wicked by the wicking tip from a first end of the wicking tip to the detection surface ...

ANALYTE SENSING DEVICE

An analyte sensing device and a mobile device incorporating an analyte sensing device are disclosed. One example of an analyte sensing device is disclosed to include a body, a sensor die, and a substantially transparent material positioned such that the sensor die is sandwiched between the body and the substantially transparent material. The sensor die may be in optical communication with the substantially transparent material and in electrical communication with the body. 1. A sensing device for detecting one or more analytes , the sensing device comprising:a body;a sensor die; and a detection surface exposed such that the detection surface is adaptable to be in direct contact with the one or more analytes; and', the chemochromic material exhibits a first color in a first state, and a second color in a second state when exposed to a predetermined analyte,', 'the sensor die is configured to detect the change in color of the chemochromic material, and', 'the chemochromic material, the detection surface, and the substantially transparent material are integrally formed in a semiconductor package., 'a chemochromic material disposed at least partially adjacent to the detection surface such that a portion of the chemochromic material is configured to be exposed to the one or more analytes through the detection surface, wherein'}], 'a substantially transparent material positioned such that the sensor die is sandwiched between the body and the substantially transparent material, wherein the sensor die is in optical communication with the substantially transparent material and in electrical communication with the body, and wherein the substantially transparent material comprises2. The sensing device of further comprising:an emitter arranged such that an optical signal emitted from the emitter is directed to the substantially transparent material so as to be reflected to the sensor die by the detection surface after passing through the chemochromic material.3. The sensing ...

REPLACEMENT INDICATOR, ELASTOMERIC ARTICLES AND METHODS

A replacement indicator can be operatively associated with an elastomeric article such that the replacement indicator is visually observable. In some cases, the replacement indicator can be secured on or along the elastomeric article. Gas spring assemblies and pneumatic tires including a replacement indicator, as well as methods of manufacture are also included. 1. A replacement indicator for use in cooperation with an associated elastomeric article , said replacement indicator comprising a material having a visually-observable characteristic that changes from a first condition to a second condition that is different from said first condition upon exposure to a predetermined level of one or more environmental agents with said change from said first condition to said second condition capable of being correlated to a change in a material characteristic of the associated elastomeric article.2. A replacement indicator according to claim 1 , wherein said one or more environmental agents includes ozone (O).3. A replacement indicator according to claim 1 , wherein said one or more environmental agents includes oxygen (O).4. A replacement indicator according to claim 1 , wherein said one or more environmental agents includes heat.5. A replacement indicator according to further comprising an adhesive layer.6. A replacement indicator according to further comprising a protective layer extending across at least a portion of said adhesive layer such that said protective layer can at least partially inhibit inadvertent adhesion of said adhesive layer to an object prior to use.7. A replacement indicator according to claim 1 , further comprising a protective layer extending across at least a portion of said material such that said protective layer can at least partially inhibit exposure of said material to said one or more environmental agents prior to use.8. A replacement indicator according to claim 1 , wherein said first condition of said visually-observable characteristic ...

RESPONSIVE INTERFERENCE COLORATION

A three-layer system composed of a substrate, a metal or metal alloy thin film deposited on the substrate surface, and an overlaid stimulus-responsive polymer layer detects changes in environmental conditions brought about by physical, chemical, or biological stimuli. The thin metal or metal alloy film functions as an optical filter and the polymer layer changes properties (e.g., dimensions) in response to changing environmental conditions that manifests as a change in wavelength of reflected or filtered light. The system is useful in colorimetric sensors. 1. A responsive interference coloration system comprising:(a) a substrate, the substrate having a first surface;(b) a thin film of a metal or metal alloy, the thin film being a continuous film on at least a portion of the first surface of the substrate; and(c) a polymer layer, the polymer layer being coated on the thin film and the polymer of the polymer layer being a stimulus-responsive polymer;wherein the thin film has a thickness configured to filter electromagnetic radiation.2. The system of claim 1 , wherein the electromagnetic radiation is visible light claim 1 , ultraviolet light claim 1 , or infrared light claim 1 , or a combination thereof.3. The system of or claim 1 , wherein the thin film is deposited on the first surface of the substrate by physical or chemical deposition methods.4. The system of or claim 1 , wherein the thin film is deposited on the first surface of the substrate by thermal evaporation claim 1 , sputter coating claim 1 , or electroless plating.5. The system of any of - claim 1 , wherein the thin film is a thin film of aluminum claim 1 , indium claim 1 , silver claim 1 , nichrome claim 1 , copper claim 1 , titanium claim 1 , chromium claim 1 , nickel claim 1 , palladium claim 1 , zinc claim 1 , iron claim 1 , carbon claim 1 , gallium claim 1 , indium claim 1 , silicon claim 1 , germanium claim 1 , tin claim 1 , selenium claim 1 , or tellurium claim 1 , or a combination thereof.6. The ...

ANALYZER AND ANALYSIS METHOD

Provided are an analyzer that analyzes a specimen with high accuracy and an analysis method for analyzing a specimen with high accuracy. The analyzer according to the present disclosure include a first reaction vessel which contains a reagent, a second reaction vessel which contains a specimen and the reagent, a detector which detects optical characteristics of the first reaction vessel and optical characteristics of the second reaction vessel, and a controller which analyzes components of the specimen in the second reaction vessel using the optical characteristics of the first reaction vessel as a baseline. 1. An analyzer , comprising:a first reaction vessel which contains a reagent;a second reaction vessel which contains a specimen and the reagent;a detector which detects optical characteristics of the first reaction vessel and optical characteristics of the second reaction vessel; anda controller which analyzes components of the specimen in the second reaction vessel using the optical characteristics of the first reaction vessel as a baseline.2. The analyzer according to claim 1 , wherein the detector simultaneously detects the optical characteristics of the first reaction vessel and the optical characteristics of the second reaction vessel.3. The analyzer according to claim 1 , wherein the second reaction vessel is disposed in close proximity to the first reaction vessel.4. The analyzer according to claim 1 , wherein the second reaction vessel is disposed adjacent to the first reaction vessel.5. The analyzer according to claim 1 , wherein the first reaction vessel and the second reaction vessel have a volume of more than 0 μL and less than 100 μL.6. The analyzer according to claim 1 , wherein the detector includes at least one set of a light emitter and a light receiver.7. The analyzer according to claim 1 , further comprising an imaging unit which captures an image of the first reaction vessel and the second reaction vessel.8. The analyzer according to claim 7 ...

SYSTEM FOR ANALYZING A LIQUID SAMPLE

The invention relates to a system for analyzing a liquid sample, including an analysis device comprising a casing including a through-opening leading into a housing adapted to receive a portion of a collecting device and extending longitudinally from the opening along an axis of insertion of the collecting device. The analysis system further includes a collecting device comprising a main body extending along a longitudinal axis and including a fluid chamber adapted to be inserted in the housing along the insertion axis and a receiving surface intended to receive the liquid sample extending substantially orthogonally relative to the axis of the main body. 118-. (canceled)20. The system according to claim 19 , wherein the housing of the analysis device and the collecting device are both sized so that claim 19 , when the main body of the collecting device is inserted in the housing claim 19 , the distance between the collecting orifice and the measuring chamber is approximately equal to the distance between the opening of the housing and the measuring chamber claim 19 , and is preferably less than or equal to 2 cm.21. The system according to claim 19 , wherein the collecting device includes a collecting portion assembled to the main body and one surface of which forms the receiving surface claim 19 , this collecting portion being in contact with a wall of the casing at the edge of the opening of the housing when the main body of the collecting device is inserted in the housing.22. The system according to claim 19 , wherein the casing includes an upper wall and a lower wall connected to each other by a lateral wall having dimensions less than the dimensions of the upper and lower walls claim 19 , the opening of the housing is situated at the level of the upper wall of the casing and the housing extends substantially orthogonally to the latter in the direction of the lower wall.23. The system according to claim 22 , wherein the upper wall of the casing comprises a ...

WETNESS INDICATOR WITH TWO COLORANTS AND TWO STABILIZERS

A wetness indicator comprising a first and second colorant and a first and second stabilizer, wherein the pKa of the first stabilizer is from about two units below to about one unit above the pKa of the first colorant, and wherein the pKa of the second stabilizer is from about two units below to about one unit above the pKa of the second colorant. 1. A wetness indicator comprising:(a) a first colorant and a second colorant;(b) a first stabilizer and a second stabilizer;(c) wherein the pKa of the first stabilizer is from about two units below to about one unit above the pKa of the first colorant; and(d) wherein the pKa of the second stabilizer is from about two units below to about one unit above the pKa of the second colorant.2. The wetness indicator of claim 1 , wherein the first stabilizer and the second stabilizer are acid stabilizers.3. The wetness indicator of claim 1 , wherein the pKa of the first colorant is from about 1.5 to about 3.5.4. The wetness indicator of claim 1 , wherein the first colorant is phloxine B acid.5. The wetness indicator of claim 1 , wherein the pKa of the second colorant is from about 3.0 to about 5.0.6. The wetness indicator of claim 1 , wherein the second colorant is selected from the group consisting of the free acid of bromophenol blue claim 1 , the free acid of bromocresol purple claim 1 , and the free acid of bromocresol green.7. The wetness indicator of claim 1 , wherein the first stabilizer is a phosphorous based acid selected from the group consisting of cetyl phosphate claim 1 , stearyl phosphate claim 1 , cetearyl phosphate claim 1 , dicetyl phosphate claim 1 , distearyl phosphate claim 1 , dicetearyl phosphate claim 1 , phosphorous acid claim 1 , phosphoric acid claim 1 , and combinations thereof.8. The wetness indicator of claim 1 , wherein the pKa of the second colorant is from about 3.5 to about 7.0.9. The wetness indicator of claim 1 , further comprising a third and/or fourth colorant selected from the group consisting ...

METHOD AND ASSEMBLY FOR DETERMINING THE TEMPERATURE OF A TEST SENSOR

An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature. 124-. (canceled)25. A test sensor for determining an analyte concentration in a fluid sample , comprising:a fluid-receiving area for receiving a fluid sample, the fluid-receiving area including a reagent that produces a measurable reaction with an analyte in the sample, the test sensor having a test-sensor temperature and the reagent having a reagent temperature; anda temperature-dependent element disposed along a surface of the test sensor,wherein the test sensor is configured to be received in the opening of a meter, the temperature-dependent element being disposed along the surface of the test sensor so that the temperature-dependent element can be detected inside the meter when the test sensor is received into the opening, the meter being configured to determine a measurement of the reaction between the reagent and the analyte, the meter including a temperature-measuring system configured to determine a measurement of the test-sensor temperature from the temperature-dependent element when the temperature-dependent element is inside the meter, the meter being configured to determine a concentration of the analyte in the sample using the measurement of ...

ANALYTE EXTRACTION APPARATUS AND METHOD

Disclosed is a method and apparatus for determining a concentration of a glycopeptide antibiotic containing a phenol moiety such as Vancomycin in a complex sample matrix by extracting the glycopeptide antibiotic from a metered portion of the complex sample matrix by exposing said metered portion to an extraction material having an affinity with the glycopeptide antibiotic; and exposing the extraction material to a metered portion of an eluent for releasing the glycopeptide antibiotic from the extraction material; and by determining a concentration of the glycopeptide antibiotic by adding a Gibbs reagent (2,6 dichloroquinone-4chloroimide) to the metered portion of the complex sample matrix or the eluent; activating the Gibbs reagent and, after the reaction between the activated Gibbs reagent and the antibiotic has stabilized; detecting the reaction product of the activated Gibbs reagent and the antibiotic in said eluent; and determining the concentration of the antibiotic in the complex sample matrix from the detected reaction product. A method of designing a personalized drug administration regime using the thus obtained concentration is also disclosed. 1. A method of determining a concentration of a glycopeptide antibiotic containing a phenol moiety in a complex sample matrix , the method comprising:extracting the glycopeptide antibiotic from a metered portion of the complexsample matrix by:exposing said metered portion to an extraction material having an affinity with the glycopeptide antibiotic; andexposing the extraction material to a metered portion of a first eluent being a first organic solvent or a second eluent being a second organic solvent/water mixture for releasing the glycopeptide antibiotic from the extraction material; anddetermining a concentration of the glycopeptide antibiotic by:adding an excess amount of Gibbs reagent (2,6 dichloroquinone-4-chloroimide) relative to the amount of the glycopeptide antibiotic to the metered portion of the first or ...

REACTIVE INDICATOR COMPOSITIONS AND ARTICLES CONTAINING SAME

An indicator composition can be used to detect various environmental conditions stimuli such as in sterilization or storage processes. This indicator composition has a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 μm; and b) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to a chosen environmental condition stimulus. The indicator composition can be used by exposing it to the environmental condition stimulus for a sufficient time to cause a detectable change in the indicator composition such as a detectable color change. 1. An indicator composition comprising:a) a first polymeric particle comprising a solid continuous polymeric phase and a first reactant, the first polymeric particle having a mode particle size equal to or less than 50 μm; andb) a second reactant outside of the first polymeric particle, which second reactant is capable of reacting with the first reactant when exposed to an environmental condition stimulus.2. The indicator composition of claim 1 , wherein the first polymeric particle further comprises one or more discrete compartments dispersed within the solid continuous polymeric phase.3. The indicator composition of claim 1 , wherein the first reactant is predominantly within the volume of the one or more discrete compartments.4. The indicator composition of further comprising an organic polymeric matrix that comprises a polyvinyl alcohol claim 1 , a poly(vinyl pyrrolidone) claim 1 , a polyurethane claim 1 , a urethane-acrylic copolymer claim 1 , an acrylic polymer claim 1 , a styrene-acrylic copolymer claim 1 , or a polyester ionomer.5. The indicator composition of claim 1 , wherein the first polymeric particle has a mode particle size of at least 1 μm and up to and including 20 μm.6. The indicator composition of claim 1 , ...

COLORIMETRIC DETECTION OF AMINE-BASED SHALE INHIBITORS

A method of detecting an amine-based shale inhibitor in a wellbore servicing fluid (WSF) comprising contacting an aliquot of the WSF with an amine detector compound to form a detection solution; wherein the WSF comprises the amine-based shale inhibitor; and wherein the detection solution is characterized by at least one absorption peak wavelength in the range of from about 380 nm to about 760 nm; detecting an absorption intensity for the detection solution at a wavelength within about +20% of the at least one absorption peak wavelength; comparing the absorption intensity of the detection solution at the wavelength within about +20% of the at least one absorption peak wavelength with a target absorption intensity of the amine-based shale inhibitor to determine the amount of amine-based shale inhibitor in the WSF; and comparing the amount of amine-based shale inhibitor in the WSF with a target amount of the amine-based shale inhibitor. 1. A method of detecting an amine-based shale inhibitor in a wellbore servicing fluid (WSF) comprising:(a) contacting an aliquot of the WSF with an amine detector compound to form a detection solution; wherein the WSF comprises the amine-based shale inhibitor; and wherein the detection solution is characterized by at least one absorption peak wavelength in the range of from about 380 nanometers (nm) to about 760 nm;(b) detecting an absorption intensity for the detection solution at a wavelength within about +20% of the at least one absorption peak wavelength;(c) comparing the absorption intensity of the detection solution at the wavelength within about +20% of the at least one absorption peak wavelength with a target absorption intensity of the amine-based shale inhibitor to determine the amount of amine-based shale inhibitor in the WSF; and(d) comparing the amount of amine-based shale inhibitor in the WSF with a target amount of the amine-based shale inhibitor.2. The method of claim 1 , wherein (b) detecting an absorption intensity for ...

Low-powered system for driving a fuel control mechanism

A low powered system for providing sufficient current to a fuel control mechanism drive. The system may have a fuel control mechanism pick circuit that has an energy storage mechanism for providing a large amount of current for a short time to the fuel control mechanism drive. A safety switch may be enabled with a special signal to let current flow to the fuel control mechanism drive to operate a corresponding fuel control mechanism for controlling fuel to a pilot light or heating element. The pilot light or heating element may provide heat to a thermoelectric source that generates electrical power from the heat. The electrical power may go to a single DC-to-DC converter and voltage clamp for providing a voltage source to a microcontroller and other circuits of the system. The pick circuit may prevent a harmful reverse flow of current from the storage mechanism to the thermoelectric source.

HANDHELD DIAGNOSTIC TEST DEVICE AND METHOD FOR USE WITH AN ELECTRONIC DEVICE AND A TEST CARTRIDGE IN A RAPID DIAGNOSTIC TEST

A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an uploading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step. 2. A method according to claim 1 , wherein in the connecting step claim 1 , the test device connection element is connected with the electronic device connection element in selectively disconnectable relation.3. A method according to claim 1 , wherein during the waiting step claim 1 , the algorithms enable the electronic device processor to generate time counting data claim 1 , with the time counting data forming at least a portion of the presentation data presented to the user.4. A method according to claim 1 , wherein before the electronic device processing step claim 1 , the test data is electronically transmitted from the sensors to the electronic device via the test device connection element and the electronic device connection element; and wherein in the electronic device processing step claim 1 , the algorithms enable the electronic device processor to generate test results based on the test data claim 1 , with the test results forming at least part of the presentation data for presentation to the user.5. A method according to claim 1 , further comprising a test device processing step claim ...

URINALYSIS DEVICE AND DRY REAGENT FOR QUANTITATIVE URINALYSIS

There is disclosed herein a method of quantitatively determining the concentration of at least one analyte in a sample, the method comprising the steps of either: (i) adding a portion of the sample to a first analyte assay formulation and to an analyte assay reference formulation to generate a first analyte sample and analyte reference sample and determining the concentration of the at least one analyte in the sample and/or (ii) adding a portion of the sample to a second analyte assay formulation and determining the concentration of the at least one analyte in the sample. Also disclosed herein are formulations, kits of parts, systems and computer implemented methods associated with said method. 164-. (canceled)65. A method of quantitatively determining the concentration of at least one first analyte in a sample , the method comprising the steps of:(a) adding a portion of the sample to a first analyte assay formulation comprising a first analyte complexing reagent to generate a first analyte sample;(b) adding a portion of the sample to an analyte assay reference formulation that is identical to the first analyte assay formulation, except that it further comprises a reagent that denatures the analyte or blocks the formation of a complex between the analyte and the first analyte complexing reagent, to generate an analyte reference sample; and(c) determining the concentration of the at least one first analyte in the sample by measuring the absorbance spectra of the first analyte sample and analyte reference sample, calculating the difference between the absorbance spectra of the first analyte sample and the analyte reference sample and comparing the difference spectrum obtained to a first pre-determined calibration curve of analyte concentration;wherein the at least one first analyte is albumin.66. The method of claim 65 , wherein the method further comprises determining the concentration of at least one second analyte in the sample claim 65 , the method comprising the ...

BIOCHIP IMAGE-FORMING SYSTEM

The present invention provides a biochip image-forming system including a case having a cavity, an optical assembly, a chip-holding assembly and an electricity storage assembly. The cavity communicates with a chip inlet for a biochip to be inserted into the cavity through the chip inlet and an image outlet for an image of the biochip to be outputted from the cavity via the image outlet. The optical assembly is received in the cavity and aligned with the image outlet for forming the image of the biochip. The chip-holding assembly is received in the cavity and arranged between the optical assembly and a heating component. The chip-holding assembly aligns with the chip inlet for the biochip to be placed thereon. The electricity storage assembly is electrically connected with the optical assembly and the heating component. As such, a biochip can be analyzed conveniently using said biochip image-forming system. 1. A biochip image-forming system , comprising:a case having a cavity, wherein the cavity communicates with a chip inlet for a biochip to be inserted into the cavity through the chip inlet and an image outlet for an image of the biochip to be outputted from the cavity via the image outlet;an optical assembly received in the cavity and aligned with the image outlet for forming the image of the biochip;a chip-holding assembly received in the cavity and arranged between the optical assembly and a heating component, wherein the chip-holding assembly aligns with the chip inlet for the biochip to be placed thereon; andan electricity storage assembly electrically connected with the optical assembly and the heating component.2. The biochip image-forming system as claimed in claim 1 , wherein the optical assembly comprises a lens assembly arranged between the image outlet and the chip-holding assembly and a backlight component fitted around the lens assembly for emitting light towards the chip-holding assembly.3. The biochip image-forming system as claimed in claim 2 , ...

Time Passage Indicator

There is described an indicator device for indicating the passage of time, the indicator device comprising an indicator section and a barrier section adjacent thereto, said indicator section comprising: an indicator material; a substrate material; and a first adhesive layer; the indicator material and the substrate material being in the form of one or more layers; the indicator material displaying different visible properties in response to the presence or absence of a chemical agent and/or the concentration thereof; the barrier section comprising a removable barrier layer, the removable barrier layer being substantially impermeable to the chemical agent; wherein on removal of the removable barrier layer, the concentration of the chemical agent in the indicator section changes over time, effecting a visible change. The device may be used to detect the presence/absence of oxygen, water, carbon dioxide, an amine, ammonia, and/or carboxylic acids or to indicate the passage of time. 1. An indicator device for indicating the passage of time , the indicator device comprising: an indicator material;', 'a substrate material; and', 'a first adhesive layer;', 'the indicator material and the substrate material being in the form of one or more layers;', 'the indicator material displaying different visible properties in response to the presence or absence of at least one of a chemical agent the and a concentration of the chemical agent;, 'an indicator section and a barrier section adjacent to the indicator section, the indicator section comprisingthe barrier section comprising a removable barrier layer, the removable barrier layer being substantially impermeable to the chemical agent;wherein upon removal of the removable barrier layer, the concentration of the chemical agent in the indicator section changes over time, effecting a change in visible properties of the indicator material.2. The indicator device of claim 1 , wherein the indicator section comprises the chemical agent ...

Smart Sticker for Use with Perishable Foods

A smart sticker for determining the current state of raw meat for safe human consumption is provided. The smart sticker indicates the quality or decomposition of the meat by changing color. The smart sticker employs a cupric nitrate solution mixed with a polymeric silicon substrate that forms a complex with the valence electrons on the nitrogen atom of an amino acid residue. After this interaction occurs, the smart sticker changes color from, for example, light blue to purple. 1. A smart sticker used to detect meat decomposition caused by a regular spoliation process , the smart sticker comprising:a. an additive containing cupric nitrate;b. a polymeric silicon substrate;c. a solid state sticker formed by the combination of the additive and the polymeric silicon substrate;d. wherein a reaction between a valence electron pair and cupric nitrate ions causes the smart sticker to change color indicating decomposition of protein.2. The smart sticker of claim 1 , wherein the smart sticker changes color when it detects the valence electrons on a nitrogen atom of an amino acid residue after the three-dimensional structures of proteins break down.3. The smart sticker of claim 1 , wherein the smart sticker is at least three millimeters thick.4. The smart sticker of claim 1 , wherein the additive is a solution of cupric nitrate mixed with a mild base and a salt.5. The smart sticker of claim 1 , wherein the color change occurs as a result of electron flow.6. The smart sticker of claim 1 , wherein the smart sticker detects valence electron pairs on biogenic amines and alcohols that are produced by the decomposition of food.7. The smart sticker of claim 1 , wherein the color-change is from light blue to purple.8. A smart sticker applied directly to the surface of raw food used to indicate deterioration by undergoing a complexing reaction with valence electron pairs on amino acid residues claim 1 , the smart sticker comprising:a. a substrate, the substrate containing a polymeric ...

RETROREFLECTOR PROVIDING THE FUNCTIONS OF RETROREFLECTION AND PICKUP OF A PARAMETER OF THE ENVIRONMENT

The invention relates to a retroreflector able to be placed in contact with an environment, comprising, by way of constituent material, a material enabling a parameter of said environment to be picked up, said material modifying the optical transmission properties of the retroreflector when said parameter is present, said retroreflector being able to receive an incident light beam via a first face and to reemit a light beam via said first face. 1. A retroreflector capable of being placed in contact with an environment , comprising , as a constitutive material , the material comprised between the faces of the retroreflector and also delimiting the latter , a porous material capturing a parameter of said environment , said parameter of said environment being a gas , said material inducing a modification of the optical transmission properties of the retroreflector , in the presence of said parameter and said retroreflector being able to receive an incident light beam through a first face and of re-emitting a light beam through said first face.2. The retroreflector according to claim 1 , which comprises three first faces claim 1 , so called rear faces claim 1 , defining a trihedron claim 1 , said three faces being convergent in a point forming an apex of the trihedron claim 1 , and a fourth face claim 1 , a so called opposite front face to said apex of the trihedron claim 1 , and containing said trihedron claim 1 , said material extending between these faces.3. The retroreflector according to claim 2 , wherein each rear face respectively extends along a first plane claim 2 , a second plane and a third plane claim 2 , said planes being substantially orthogonal with each other claim 2 , the light beam emerging along a direction substantially parallel to that of the incident light beam.4. The retroreflector according to claim 1 , which has a cube corner shape.5. The retroreflector according to claim 1 , wherein the porous material is a material with open porosity.6. The ...

WEARABLE WITH TEST STRIPS AND OPTICAL READER FOR SKIN

The present invention generally relates to a wearable electronic device that collects information about test sample using an optical sensor. The wearable device photographs and analyzes one or more organic samples placed on one or more immunoassay regions of a test strip in order to reveal information about the sample. The wearable electronic device may also sequentially photograph a plurality of individual organic samples applied to different immunoassay regions of a test strip. 1. A wearable sample analysis device , the apparatus comprising:a chamber comprising at least a portion of a rotatable test strip, wherein the test strip comprises a plurality of spaced immunoassay regions;an opening in the wearable device, wherein the opening receives a sample from the skin of a person, and wherein the sample accesses one of the plurality of spaced immunoassay regions;a rotatable carousel, where in the rotatable carousel moves the rotatable test strip from a first position to a second position, wherein in each of said first and second positions a respective one of the plurality of immunoassay regions is aligned with said opening to receive a sample;an optical reader, wherein the optical reader acquires an optical image of a first immunoassay region of the plurality of immunoassay regions of the test strip when the test strip is in the first position, and further acquires an optical image of a second immunoassay region of the plurality of immunoassay regions of the test strip when the test strip is in the second position; anda processor in communication with the optical reader, wherein the processor analyzes at least one of the first and second optical images;wherein the test strip is removed from the chamber after each of the plurality of immunoassay regions have received a sample via the opening.2. (canceled)3. The wearable sample analysis device of claim 1 , wherein the processor identifies at least one color characteristic of the optical image of the first immunoassay ...

METHOD OF ANALYZING GLYCATED PROTEIN, ANALYSIS REAGENT, ANALYSIS KIT, AND TEST PIECE FOR ANALYSIS

A method of analyzing a glycated protein, including reacting a color developer represented by the following Formula (1) with a biological sample; and measuring a color reaction of the color developer, 2. The method according to claim 1 , wherein the biological sample is a blood sample.3. The method according to claim 2 , wherein the blood sample is a serum sample or a plasma sample.4. The method according to claim 1 , wherein the biological sample in a liquid state is added to the color developer in a dry state.5. The method according to claim 1 , wherein the glycated protein is fructosamine.6. The method according to claim 1 , wherein the color developer is contained in a reagent.7. The method according to claim 6 , wherein the reagent is included in a kit.8. The method according to claim 1 , wherein in the method claim 1 , the reaction is carried out in a test piece comprising a substrate claim 1 ,wherein the substrate comprises a sample supply region and a reaction region, the sample supply region and the reaction region are connected by a flow channel, the reagent containing the color developer is placed at the reaction region, and the reaction region in the substrate is composed of a transparent member.9. The method according to claim 8 ,wherein the substrate is a layered body comprising an upper substrate and a lower substrate, the inside of the layered body comprises a first space, a second space, and the flow channel connecting the first space and the second space, the upper substrate comprises an opening at a position corresponding to the first space, the opening of the upper substrate and the first space form the sample supply region, the opening is a sample inlet, the second space is the reaction region, and the reagent is placed in at least a region of the upper substrate or a region of the lower substrate, the regions corresponding to the second space. This application claims priority from Japanese Patent Application No. 2016-087040, filed on Apr. 25, ...

Method for estimating an amount of analyte in a fluid

The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood.

COMPONENT MEASUREMENT DEVICE, COMPONENT MEASUREMENT METHOD, AND COMPONENT MEASUREMENT PROGRAM

A component measurement device for measuring a component of interest in blood based on an optical property of a mixture containing a pigmentary component colored by a color reaction between the component of interest in the blood and a reagent, the component measurement device including: an absorbance obtaining unit configured to obtain a measured value of absorbance of the mixture at a measuring wavelength; and an absorbance correction unit configured to correct the measured value of absorbance of the mixture at the measuring wavelength based on information on scattered light and a ratio between reduced hemoglobin and oxygenated hemoglobin in erythrocytes. 1. A component measurement device for measuring a component of interest in blood based on an optical property of a mixture containing a pigmentary component colored by a color reaction between the component of interest in the blood and a reagent , the component measurement device comprising:an absorbance obtaining unit configured to obtain a measured value of absorbance of the mixture at a measuring wavelength; andan absorbance correction unit configured to correct the measured value of absorbance of the mixture at the measuring wavelength based on information on scattered light and a ratio between reduced hemoglobin and oxygenated hemoglobin in erythrocytes.2. The component measurement device according to claim 1 , wherein: obtain a first measured value of absorbance of the mixture at a first wavelength and a second measured value of absorbance of the mixture at a second wavelength, both of which are within a wavelength band longer than the measuring wavelength within a wavelength band corresponding to a full width at half maximum of a peak wavelength band in an absorbance spectrum of the pigmentary component, and', 'obtain a third measured value of absorbance of the mixture at a third wavelength and a fourth measured value of absorbance of the mixture at a fourth wavelength, both of which are within a wavelength ...

COMPONENT MEASUREMENT DEVICE AND COMPONENT MEASUREMENT DEVICE SET

A component measurement device for measuring a component of interest in blood on a basis of optical characteristics of a mixture containing a color component produced by a color reaction between the component of interest in the blood and a reagent includes: a first light source configured to emit first irradiation light of a first predetermined wavelength to the mixture; and a second light source configured to emit second irradiation light of a second predetermined wavelength to the mixture, the second irradiation light to be used for estimation of a noise amount contained in a measured value of absorbance of the mixture measured by using the first irradiation light of the first light source, the noise amount being derived other than from the color component. 1. A component measurement device for measuring a component of interest in blood on a basis of optical characteristics of a mixture containing a color component produced by a color reaction between the component of interest in the blood and a reagent , the component measurement device comprising:a first light source configured to emit first irradiation light of a first predetermined wavelength to the mixture; anda second light source configured to emit second irradiation light of a second predetermined wavelength to the mixture, the second irradiation light to be used for estimation of a noise amount contained in a measured value of absorbance of the mixture measured by using the first irradiation light of the first light source, the noise amount being derived other than from the color component;wherein the first light source and the second light source are aligned in a flow path width direction perpendicular to a flow direction of the blood at a position where the mixture is present in a flow path of the blood.2. The component measurement device according to claim 1 , wherein:the first light source is configured to irradiate the first irradiation light to the mixture at a first irradiation position, and the ...

Membrane Carrier, Kit for Testing Liquid Sample Using Same, and Manufacturing Method Thereof

The present invention provides a membrane carrier comprising a flow path , wherein a microstructure is formed at a bottom of the flow path , and a particle to which an antibody or an antigen binds is arranged in at least a part on the flow path, the particle having a diameter of 500 nm or more and 100 μm or less. 1. A membrane carrier comprising a flow path , whereina microstructure is formed at a bottom of the flow path, anda particle to which an antibody or an antigen binds is arranged in at least a part on the flow path, the particle having a diameter of 500 nm or more and 100 μm or less.2. The membrane carrier according to claim 1 , wherein an average horizontal distance between adjacent microstructures is at least 3 times the diameter of the particle and 300 μm or less.3. The membrane carrier according to claim 1 , wherein the particle is one or more selected from the group consisting of a colored latex particle and a fluorescent latex particle.4. The membrane carrier according to claim 1 , whereinthe membrane carrier is a membrane carrier for a test kit of detecting a target substance in a liquid sample, andthe antibody and antigen specifically react with a target substance in the liquid sample.5. The membrane carrier according to claim 4 , comprising a detection zone for detecting the target substance in the liquid sample.6. The membrane carrier according to claim 5 , wherein the detection zone produces a color change when the target substance is detected.7. A method for manufacturing a liquid sample test kit claim 6 , comprising immobilizing a detection substance producing a color change by holding a target substance in the detection zone of the membrane carrier according to .8. A liquid sample test kit comprising the membrane carrier according to . The present invention relates to a membrane carrier, a liquid sample test kit using the carrier and a method for producing the test kit.Recently, Point of Care Testing (POCT) reagents using, for example, antigen- ...

METHOD FOR ESTIMATING AN AMOUNT OF ANALYTE IN A FLUID

The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood. 1. A method for determining a lysis of particles , the particles lying within a fluid sample , the method comprising:mixing the sample with a lysis reagent, the lysis reagent being configured to lyse some particles;illuminating the sample using a light source configured to emit light toward the sample;acquiring, using an image sensor, an image of light transmitted or reflected by the sample, the image sensor comprising pixels;calculating a lysis indicator from the image, the lysis indicator representing a progress of the lysis of particles in the sample.3. The method of claim 2 , wherein the dispersion term is derived from the variance or the standard deviation of the image acquired by the image sensor.4. The method of claim 1 , wherein two images are acquired by the image sensor at two different times respectively claim 1 , the method further comprising comparing the two images; and wherein the lysis indicator is derived from the comparison of the two images.5. The method of claim 4 , wherein the comparison is performed by calculating a difference between the two images or by calculating a correlation between the two images.6. The method of claim 4 , further comprising forming a comparative image representing a comparison between the two images acquired claim 4 , and calculating a statistical quantity of the comparative image claim 4 , the statistical quantity being for example a ...