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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 554. Отображено 100.
24-10-2013 дата публикации

SYSTEMS AND METHODS TO COMPENSATE FOR SOURCES OF ERROR DURING ELECTROCHEMICAL TESTING

Номер: US20130277234A1
Автор: Burke David W., Marquant Michael, Surridge Nigel A.
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A method is disclosed for determining analyte concentration that includes applying a first electrical potential excitation pulse to a body fluid sample in an analyte sensor, and a first current response of the body fluid sample to the first pulse is measured. A second excitation pulse is applied to the body fluid sample in the analyte sensor, and a second current response of the body fluid sample to the second pulse is measured. An analyte level in the body fluid sample is determined by compensating for sources of error based on the first current response to the first pulse. 1. A method comprising:applying a first direct current (DC) pulse of electrical excitation to a body fluid sample in an analyte sensor, the first DC pulse being sufficient to generate a first current response;determining a first plurality of current measurements by measuring the first current response at a plurality of times during the first DC pulse, the first plurality of current measurements being sufficient to identify a compensation based on one or both of reaction rate and blank current interferent;applying a second DC pulse of electrical excitation to the body fluid sample, the second DC pulse being sufficient to generate a second current response;determining a second plurality of current measurements by measuring the second current response at a plurality of times during the second DC pulse; anddetermining a concentration of an analyte in the body fluid sample based on the first and second pluralities of current measurements, wherein the determined concentration is compensated for one or both of reaction rate and blank current interferent sources as a result of the first plurality of current measurements, and wherein the determined concentration is compensated based on a reaction rate determined by measuring a time to reach peak current response during the first DC pulse and/or is based on a reaction rate determined by the shape of the first current response to the first DC pulse.2. The ...

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Номер записи: 1
14-11-2013 дата публикации

TEMPERATURE SENSING ANALYTE SENSORS, SYSTEMS, AND METHODS OF MANUFACTURING AND USING SAME

Номер: US20130298648A1
Автор: Charlton Steven C., Creaven John P., Ripley Paul M., Sun Hoi-Cheong Steve, Wu Mu
Принадлежит: Bayer HealthCare LLC

An analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects. 1. An analyte sensor , comprising:a first electrode having a contact engagement portion and a sensing portion;a second electrode having a contact engagement portion and a sensing portion;an active region provided in contact with, and extending between, the sensing portions of the first electrode and the second electrode; anda thermocouple portion comprising at least part of a conducting path from the active region to the contact engagement portion of the second electrode.2. The analyte sensor of claim 1 , wherein the first electrode comprises a working electrode claim 1 , and the second electrode comprises a counter or reference electrode.3. The analyte sensor of claim 1 , wherein the contact engagement portions are the only two contact engagement portions of the analyte sensor.4. The analyte sensor of claim 1 , comprising a base claim 1 , the first electrode and the second electrode extending along the base.5. The analyte sensor of claim 1 , wherein the first electrode comprises a different conductive material than the thermocouple portion of the second electrode.6. The analyte sensor of claim 1 , wherein the thermocouple portion comprises a carbon-based material.7. The analyte sensor of claim 4 , wherein the first electrode comprises a noble metal and the thermocouple portion comprises a carbon-based material.8. The analyte sensor of claim 1 , comprising a fuse member extending between the first electrode and the second ...

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Номер записи: 2
02-01-2014 дата публикации

ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS

Номер: US20140001042A1
Автор: Brauker James H., Carr-Brendel Victoria E., Petisce James R., Simpson Peter C.
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants. 1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid , the sensor comprising:a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte;an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; andan auxiliary electrode comprising a conductive material and configured to modify an electrochemical interferent such that the electrochemical interferent is rendered substantially electrochemically non-reactive at the working electrode.2. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a conductive material selected from the group consisting of a conductive metal claim 1 , a conductive polymer claim 1 , and a blend of a conductive metal and a conductive polymer.3. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a form selected from the group consisting of a mesh claim 1 , a grid claim 1 , and a plurality of spaced wires.4. The ...

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Номер записи: 3
30-01-2014 дата публикации

System and method for quality assurance of a biosensor test strip

Номер: US20140027279A1
Автор: Henning Groll, James L. Pauley, Michael J. Celentano, Steven K. Moore
Принадлежит: Roche Diagnostics Operations Inc

The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

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Номер записи: 4
30-01-2014 дата публикации

SYSTEM AND METHOD FOR DETECTING USED AND DRIED SENSORS

Номер: US20140027308A1
Автор: Harrison Bern
Принадлежит: Bayer HealthCare LLC

Systems and methods for detecting dried test strips are provided, where a dried test strip may be one that has been re-inoculated with a biological sample after having already been previously inoculated with another sample at an earlier time (e.g., hours or days before). In various aspects, a biosensor such as an amperometric glucose biosensor (“meter”) may apply one or more input electrical signals to an inoculated test strip having at least a pair of electrodes in contact with the biological sample. The meter may measure output current value(s) resulting in response to the input electrical signals applied to the test strip. The meter may determine whether the test strip is a dried test strip by comparing a ratio of the measured output current value(s) with a boundary ratio value. 1. A method for detecting reuse of a test strip in a biosensor , the method comprising:inoculating a test strip having a dry reagent and a plurality of electrodes including a bare electrode which is normally not in contact with the dry reagent with a liquid so that the liquid contacts the dry reagent, the bare electrode and one or more other electrodes;while the electrodes are in contact with the liquid, applying an electrical potential between the bare electrode and one or more of the other electrodes;measuring a current flow between the bare electrode and one or more of the other electrodes responsive to application of the potential; anddetermining, based on one or more parameters of the measured current flow, whether the sensor strip is one that has been previously wetted and dried before the inoculating step.2. The method of wherein the measuring step includes the step of measuring a first current value at a first time during the potential applying step and measuring a second current value at a second claim 1 , later time during the potential applying step.3. The method of claim 2 , wherein the determining step includes:calculating a ratio between the second current value and the ...

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Номер записи: 5
01-01-2015 дата публикации

TRANSIENT SIGNAL ERROR TRAP FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE

Номер: US20150001070A1
Автор: Mackintosh Stephen
Принадлежит:

Various embodiments for methods, systems, and meters that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether at least one output transient signal of the biosensor is erroneous by monitoring the biosensor and flagging an error if the signal outputs of the biosensor do not meet certain criteria. 1. An analyte measurement system comprising: a substrate;', 'a plurality of electrodes connected to respective electrode connectors; and, 'a test strip including a housing;', 'a test strip port connector configured to connect to the respective electrode connectors of the test strip; and', (a) apply a first signal to the plurality of electrodes so that a physical characteristic of a fluid sample is determined;', '(b) estimate an analyte concentration based on a predetermined sampling time point during a test sequence;', '(c) apply a second signal to a first electrode and a second electrode of the plurality of electrodes at a specified sampling time point or interval during the test sequence dictated by the determined physical characteristic;', '(d) measure a signal output at a plurality of time points including the specified sampling time for each of the first and second electrodes;', '(e) measure a signal output at a predetermined offset time interval (Δt) from the specified sampling time for each of the first and second electrodes;', '(f) evaluate, for each of the first and second electrodes, whether a slope of the signal outputs between the predetermined offset time interval (Δt) and the specified sampling time is approximately zero or increasing over time;', '(g) if the slope of the signal output for each electrode at the predetermined offset time (Δt) to the specified sampling time is decreasing then determine or calculate the analyte concentration from the signal outputs of the first and second electrodes at the specified sampling time and annunciate the analyte ...

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Номер записи: 6
01-01-2015 дата публикации

FILL ERROR TRAP FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE

Номер: US20150001096A1
Автор: Mackintosh Stephen
Принадлежит:

Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether a sample fill condition is erroneous by monitoring the working electrodes and flagging an error if the signal outputs of the working electrodes do not meet certain thresholds. 1. An analyte measurement system comprising: a substrate;', 'a plurality of electrodes connected to respective electrode connectors; and, 'a test strip including a housing;', 'a test strip port connector configured to connect to the respective electrode connectors of the test strip; and', (a) apply a first signal to the plurality of electrodes so that a physical characteristic of a fluid sample is determined;', '(b) estimate an analyte concentration based on a predetermined sampling time point during a test sequence;', '(c) apply a second signal to a first electrode and a second electrode of the plurality of electrodes at a specified sampling time point during the test sequence dictated by the determined physical characteristic so that an analyte concentration is calculated from the second signal;', '(d) measure a signal output at the specified sampling time point from each of the first and second electrodes;', '(e) evaluate whether a value defined by a difference in the magnitudes of the respective signal outputs of the first and second electrodes divided by the magnitude of the signal output of the second electrode is greater than a predetermined threshold;', '(f) if the value is less than the predetermined threshold then determine or calculate the analyte concentration from the signal outputs of the first and second electrodes at the specified sampling time and annunciate the analyte concentration; and', '(g) if the value is greater than the predetermined threshold then annunciate an error., 'a microprocessor in electrical communication with the test strip port connector to apply electrical signals or ...

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Номер записи: 7
01-01-2015 дата публикации

TEMPERATURE COMPENSATION FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE

Номер: US20150001097A1
Автор: Malecha Michael
Принадлежит:

Various embodiments for a method, systems and meters that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and compensating for the effects of ambient temperature with a defined relationship between temperature in the environment, the meter or the biosensor. 1. An analyte measurement system comprising:a biosensor having a plurality of electrodes including at least two electrodes with an enzyme disposed thereon;and measure ambient temperature proximate the biosensor;', 'drive a signal to the at least two electrodes when a fluid sample with an analyte is deposited proximate the at least two electrodes;', 'measure a signal output from the at least two electrodes during the electrochemical reaction;', 'calculate an uncompensated analyte value from the signal output;', (a) the temperature compensation term increases for increasing uncompensated analyte values; and', '(b) the temperature compensation term is inversely related to the ambient temperature proximate the biosensor from about 5 degrees Celsius to about 22 degrees Celsius; and', '(c) the temperature compensation term is about zero for the ambient temperature proximate the biosensor from about 22 degrees Celsius to about 45 degrees Celsius;, 'adjust the uncompensated analyte value to a final analyte value with a temperature compensation term defined by a relationship in which, 'and', 'annunciate the final analyte value., 'a microcontroller coupled to a power source, memory and the plurality of electrodes of the biosensor and in which the microcontroller is configured to, 'a meter including4. The system of claim 2 , in which the microcontroller is configured to:(a) apply a first signal to the plurality of electrodes so that a physical characteristic of the fluid sample is determined;(b) estimate an analyte concentration based on a predetermined sampling time point during a test sequence;(c) apply a second signal to the plurality of ...

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Номер записи: 8
07-01-2016 дата публикации

METHODS OF ELECTROCHEMICALLY MEASURING AN ANALYTE WITH A TEST SEQUENCE HAVING A PULSED DC BLOCK AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

Номер: US20160003764A1
Автор: Beaty, Carpenter Scott E., JR. Terry A., Pan Zheng Zheng, Surridge Nigel A.
Принадлежит: ROCHE DIABETES CARE, INC.

Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature or both before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one AC block and at least one pulsed DC block, where pulsed DC block includes at least one recovery potential, and where a closed circuit condition of the electrode system is maintained during the DC block. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods. 2. The method of claim 1 , wherein the AC block is applied before the DC block claim 1 , after the DC block or interspersed within the DC block.3. The method of claim 1 , wherein the AC block is applied before the DC block.4. The method of claim 1 , wherein the AC block comprises a multi-frequency excitation waveform of at least two different frequencies.5. The method of claim 4 , wherein the frequencies of the AC block are about 10 kHz claim 4 , about 20 kHz claim 4 , about 10 kHz claim 4 , about 2 kHz and about 1 kHz claim 4 , and wherein each frequency is applied for about 0.5 seconds to about 1.5 seconds.6. The method of claim 1 , wherein the DC block comprises a pulsed sequence alternating between an excitation potential and the at least one recovery potential claim 1 , and wherein the determining comprises determining an effective current based upon the information of the excitation current response and the recovery current response and determining the analyte concentration based upon the effective current.7. The method of claim 6 , wherein the pulsed sequence includes at least one pulse to about ten pulses claim 6 , wherein the excitation pulse is at about +450 mV and the recovery pulse is at about 0 mV claim 6 , and wherein each pulse is applied for about 50 msec to about 500 msec.8. The method of claim 7 , wherein ...

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Номер записи: 9
07-01-2016 дата публикации

METHODS OF USING INFORMATION FROM RECOVERY PULSES IN ELECTROCHEMICAL ANALYTE MEASUREMENTS AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

Номер: US20160003765A1
Автор: Carpenter Scott E.
Принадлежит: ROCHE DIABETES CARE, INC.

Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where the DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the at least one recovery pulse is used to correct/compensate for temperature effects on the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods. 1. A method of compensating for temperature while electrochemically measuring an analyte in a fluid sample , the method comprising the steps of:applying an electrical test sequence to an electrochemical biosensor, the biosensor comprising:an electrode system,a reagent in electrical communication with the electrode system, anda receptacle configured to contact a fluid sample provided to the test element with the reagent,with the fluid sample in fluidic contact with the reagent, wherein the test sequence comprising at least one direct current (DC) block having a sequence of at least one excitation potential pulse and at least one recovery potential pulse, wherein a closed circuit condition of the electrode system is maintained during the DC block; anddetermining the analyte concentration based upon current response information from the DC block, wherein information from the at least one recovery potential pulse is used to compensate for temperature effects on the analyte concentration based upon a partial least squares (PLS) regression model.2. The method of claim 1 , wherein the at least one excitation potential pulse is about +450 mV and the at least one recovery potential pulse is about 0 mV claim 1 , and wherein ...

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Номер записи: 10
14-01-2016 дата публикации

APPARATUS FOR READING IDENTIFICATION INFORMATION OF BIOSENSOR

Номер: US20160011139A1
Автор: Bae Byeong-Woo, Hong Jong-Won, LEE KI-WON, Lee Sung-Dong, NAM Duck-sung, Suk Hong-Seong, YOO Jina
Принадлежит: INFOPIA CO., LTD.

An apparatus for reading identification information of a biosensor is provided, including a biosensor sensing unit detecting the biosensor, a light-emitting unit emitting light on an identification information recording unit when the biosensor sensing unit detects the biosensor, the identification information recording unit having the identification information of the biosensor recorded thereon, a light-receiving unit that receives the light emitted from the light-emitting unit, and reflected or refracted by or passing through the identification information recording section and an identification information reading unit analyzing the light received by the light-receiving unit and reading the identification information of the biosensor. 1. An apparatus for reading identification information of an electro-chemical biosensor , the apparatus comprising:a switch configured to be activated by insertion of the electro-chemical biosensor into the apparatus;a light emitting unit configured to, as a causal effect of the activation of the switch, turn on and emit light onto a color tag having at least two color segments disposed on the electro-chemical biosensor;a light receiving unit configured to receive the light emitted from the light emitting unit, the received light being reflected by, refracted by, or passing through the color tag having the at least two color segments; andan identification information reading unit configured to analyze the light received by the light receiving unit and read the identification information of the electro-chemical biosensor from an arrangement of colors on the color tag.2. The apparatus of claim 1 , wherein the identification information comprises a correction code used to correct a measurement result of the electro-chemical biosensor.3. The apparatus of claim 1 , wherein the color tag is attached to the electro-chemical biosensor.4. The apparatus of claim 1 , further comprising a processor configured to cause the light emitting unit to ...

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Номер записи: 11
14-01-2016 дата публикации

METHODS OF DETECTING HIGH ANTIOXIDANT LEVELS DURING ELECTROCHEMICAL MEASUREMENTS AND FAILSAFING AN ANALYTE CONCENTRATION THEREFROM AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORTING THE SAME

Номер: US20160011140A1
Автор: Buck, Carpenter Scott E., JR. Harvey B., Pan Zheng Zheng
Принадлежит: ROCHE DIABETES CARE, INC.

Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to provide an error code or correct and/or compensate for interferents such as an antioxidant before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one DC block, such as a slow-ramped bi-polar waveform, where a closed circuit condition is maintained during the DC block. The methods use information relating to status of a redox mediator feature during the electrochemical analysis to provide an antioxidant failsafe if the antioxidant is interfering with the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods. 2. The method of further comprising the step of displaying a failsafe if the level of the antioxidant is above a predetermined threshold.3. The method of claim 2 , wherein the failsafe is an error code or a specific failsafe message.4. The method of claim 1 , wherein the redox mediator is a nitrosoanaline (NA)-derived redox mediator.5. The method of claim 4 , wherein the NA-derived redox mediator is N claim 4 ,N-bis(hydroxyethyl)-3-methoxy-4-nitrosoanaline hydrochloride.6. The method of claim 1 , wherein the SRBP waveform is at least one of a triangular potential waveform claim 1 , a trapezoidal potential waveform or a sinusoidal potential waveform.7. The method of claim 1 , wherein the SRBP waveform alternates between about −450 mV to about +450 mV at equal ramp rates claim 1 , or wherein the SRBP waveform alternates between about −450 mV to about +450 mV at two different ramp rates.8. The method of claim 7 , where the ramp rates are between about 3 mV/msec and about 9 mV/msec.9. The method of claim 1 , wherein the test sequence further comprises a second DC block that includes a sequence alternating between at least one excitation potential and at least one recovery potential claim 1 , wherein a closed ...

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Номер записи: 12
21-01-2016 дата публикации

Normalized Calibration Of Analyte Concentration Determinations

Номер: US20160018355A1
Автор: Wu Huan-Ping
Принадлежит:

Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations.

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Номер записи: 13
28-01-2016 дата публикации

System Error Compensation Of Analyte Concentration Determinations

Номер: US20160025673A1
Автор: Wu Huan-Ping
Принадлежит:

During analyte analysis, errors may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The present invention introduces the determination of a pseudo-reference concentration determined during the analysis as a substitute for the true relative error and uses an anchor parameter to compensate for the system error in the analysis-determined pseudo-reference concentration. 1. A method for determining an analyte concentration in a sample , comprising:generating at least one output signal from a sample;measuring at least one analyte responsive output signal from the sample;determining a pseudo-reference concentration value from the at least one analyte responsive output signal, where a pseudo-reference concentration value is a substitute for true relative error;determining at least one anchor parameter in response to the pseudo-reference concentration value, where the at least one anchor parameter compensates for system error,incorporating the at least one anchor parameter into a compensation relationship; anddetermining a final compensated analyte concentration of the sample in response to the compensation relationship.2. The method of claim 1 , further comprising:measuring one analyte responsive output signal from the sample;measuring at least one extraneous stimulus responsive output signal from the sample;selecting a sample analyte concentration value as the pseudo-reference concentration value, where the sample analyte concentration value for multiple analyses is on average closer to an actual ...

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Номер записи: 14
28-01-2016 дата публикации

LIQUID SAMPLE MEASUREMENT DEVICE, LIQUID SAMPLE MEASUREMENT METHOD, AND BIOSENSOR

Номер: US20160025674A1
Автор: FUJIWARA Masaki, YAMAMOTO Tomohiro
Принадлежит:

It is intended to provide, for example, a liquid sample measurement device capable of measuring the amounts of components of a liquid with a high accuracy. A first voltage is applied to an electrode pair which composes a biosensor to obtain, a first response value, a second voltage is applied to an electrode pair which composes the biosensor to obtain a second response value, and a current that is generated when a third voltage is applied to an electrode pair which composes the biosensor is detected to obtain a third response value. A liquid sample measurement device uses the first response value, the second response value, and the third response value to obtain the concentration of glucose and the amount of blood cells of blood as well as the value equivalent to the temperature of the biosensor 1. A liquid sample measurement device that measures the amounts of components using a biosensor in which a liquid is introduced and then components contained in said liquid are subjected to oxidation-reduction using an oxidoreductase ,wherein the liquid sample measurement device comprises:a first current value measure that detects, as a first current value, an oxidation-reduction current that is generated by the oxidation-reduction when a first voltage is applied to a first electrode pair, which composes the biosensor;a second current value measure that detects, as a second current value, a current that is generated when a second voltage is applied to a second electrode pair, which composes the biosensor;a third current value measure that detects, as a third current value, a current that is generated when a third voltage is applied to a third electrode pair, which composes the biosensor;a controller that controls a voltage value and a voltage application period of each of the first voltage, the second voltage, and the third voltage, that applies the second voltage and the third voltage to the second electrode pair and the third electrode pair, respectively, while the first ...

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Номер записи: 15
26-01-2017 дата публикации

HAND-HELD TEST METER WITH FLUID INGRESS DETECTION CIRCUIT

Номер: US20170023516A1
Автор: HAMER Malcolm D.
Принадлежит:

A hand-held test meter (“HHTM”) for use with analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, a strip port connector disposed at least partially within the housing, a micro-controller disposed in the housing, a voltage supply disposed in the housing, a fluid ingress detection circuit block (“FRIDCB”) disposed in the housing and includes a paired signal and ground trace, and a ground-reference. A portion of the signal trace and ground trace are separated by a predetermined distance. The signal trace is electrically connected to the voltage supply and to the micro-controller and the ground trace is electrically connected to the ground-reference. With no ingress fluid, the signal trace is electrically isolated from the ground trace. The FRIDCB generates an output signal to the micro-controller that is dependent on fluid ingress into the meter housing, thus providing for detection of fluid ingress. 1. A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample , the hand-held test meter comprising:a housing;a strip port connector disposed at least partially within the housing;a micro-controller disposed in the housing;a voltage supply disposed in the housing;a fluid ingress detection circuit block disposed in the housing and including:at least one paired signal trace and ground trace; anda ground-reference,wherein at least a portion of the at least one signal trace and at least a portion of the at least one ground trace are separated by a predetermined distance;wherein the at least one signal trace is electrically connected to the voltage supply and to the micro-controller;wherein the ground trace is electrically connected to the ground-reference; andwherein the in the absence of ingress fluid, the signal trace of the at least one paired signal trace is electrically isolated from the ground trace.2. The hand-held test meter of wherein the fluid ingress ...

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Номер записи: 16
26-01-2017 дата публикации

BIOLOGICAL INFORMATION MEASUREMENT DEVICE AND BIOLOGICAL INFORMATION MEASUREMENT METHOD USING SAME

Номер: US20170023517A1
Автор: YOSHIOKA Eriko
Принадлежит:

In a biological information measurement device for measuring, for example, a blood glucose level, it is intended to improve measurement accuracy. In a voltage sweep mode A (a biological information characteristic detection mode), different voltage values are applied between a first input terminal and a second input terminal from a voltage applying unit in a first period and a second period, a plurality of various factors that affect variation in the measurement of biological information are considered as changes in the current value in the voltage sweep mode A (the biological information characteristic detection mode), thereby a biological information correction value is calculated from the changes in the current value, and the biological information measurement value measured during the biological information measurement mode C is corrected by the biological information correction value. Thus, the measurement accuracy can be improved. 1. A biological information measurement device , to which a biosensor is attached , the biosensor having a first electrode , a second electrode , and a reagent portion provided between the first electrode and the second electrode ,wherein the biological information measurement device comprises:a first input terminal, to which the first electrode is connected, and a second input terminal, to which the second electrode is connected;a voltage applying unit for applying a voltage to the first input terminal and the second input terminal; anda control unit connected to the voltage applying unit, the first input terminal, and the second input terminal,the control unit is configured to execute a biological information characteristic detection mode and a biological information measurement mode following the biological information characteristic detection mode,during the biological information characteristic detection mode, with respect to the voltage applying unit, the control unit applies voltage values between the first input terminal and ...

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Номер записи: 17
29-01-2015 дата публикации

REAGENT COMPOSITION FOR BIOSENSORS AND BIOSENSOR COMPRISING REAGENT LAYER FORMED OF THE SAME

Номер: US20150027905A1
Автор: Kim Jisu, Lim Gueisam
Принадлежит: LG ELECTRONICS INC.

The present invention relates to a composition which reduces the measurement error caused by the effect of hematocrit in a biosensor and to a biosensor comprising the same. Specifically, the invention relates to a reagent composition comprising an enzyme, an electron transfer mediator, a water-soluble polymer, and bile acid, and to a biosensor comprising a reagent layer formed of the composition. The reagent layer reduces the measurement error caused by the effect of hematocrit in the biosensor. 1. A reagent composition for biosensors , comprising an enzyme , an electron transfer mediator , a water-soluble polymer , and bile acid.2. The reagent composition of claim 1 , wherein the bile acid is a hydroxyl derivative of cholic acid.3. The reagent composition of claim 1 , wherein the the bile acid is contained in an amount ranging from 1 to 50 wt % based on the total weight of the composition.4. The reagent composition of claim 1 , wherein the the bile acid is contained in an amount ranging from 5 to 30 wt % based on the total weight of the composition.5. A a biosensor for measuring the concentration of a specific component in a sample claim 1 , wherein bile acid is contained in a reagent layer comprising a reagent which reacts specifically with the specific component in the sample.6. The biosensor of claim 5 , wherein the concentration of the specific component is measured using electrodes claim 5 , including a working electrode and a reference electrode claim 5 , which are provided on an insulating layer.7. The biosensor of claim 6 , wherein the reagent layer comprises an enzyme and an electron transfer mediator.8. The biosensor of claim 7 , wherein the reagent layer is formed on the electrodes.9. The biosensor of claim 7 , wherein the electrodes are formed so as to be disposed in a diffusion area in which the reagent of the reagent layer is dissolved in the sample and diffused.10. The biosensor of claim 7 , wherein the enzyme is glucose oxidase.11. An ...

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Номер записи: 18
04-02-2016 дата публикации

Blood glucose measuring device and method, and electronic device including blood glucose measuring module

Номер: US20160033440A1
Автор: Chul-Ho Cho, Jae-Geol Cho, Kwang-Bok Kim, Seong-Je Cho, Sun-Tae Jung
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A method and device for measuring blood glucose are provided. The device includes a strip receiving part having a plurality of pins therein, the pins being arranged in such a manner that at least one of the pins contacts at least one electrode formed in a blood glucose measurement strip when the blood glucose measurement strip is inserted into the strip receiving part; and a controller configured to identify a type of the blood glucose measurement strip inserted into the strip receiving part and to control application of a testing voltage configured in response to the identified type of the blood glucose measurement strip to each pin of the strip receiving part.

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Номер записи: 19
30-01-2020 дата публикации

Method of operation of a meter

Номер: US20200033287A1
Автор: Chen Wen-Huang, Lee Cheng-Che
Принадлежит:

The method of operation of a meter includes placing a sample on a test strip, assigning a first electrode of the test strip to be a counter electrode, applying a first signal to the test strip during a first period of time, assigning a second electrode of the test strip to be the counter electrode, applying a second signal to the test strip to measure the concentration of an analyte in the sample. 1. A method of operation of a meter to measure a response of a sample on a reaction chamber of a test strip , comprising:assigning a first electrode of the test strip to be a counter electrode;applying a first signal to a working electrode of the test strip during a first period of time;assigning a second electrode of the test strip to be the counter electrode;applying a second signal to the working electrode of the test strip during a second period of time; andmeasuring the response during the second period of time.2. The method of claim 1 , wherein assigning the first electrode of the test strip to be the counter electrode and assigning the second electrode of the test strip to be the counter electrode is performed using at least one switch of the meter.3. The method of claim 1 , further comprising assigning the first electrode of the test strip to be a reference electrode before applying the second signal to the working electrode of the test strip during the second period of time.4. The method of claim 1 , further comprising assigning the second electrode of the test strip to be a reference electrode before applying the first signal to the working electrode of the test strip during the first period of time.5. The method of claim 1 , wherein said the response is measuring a current across the working electrode and the second electrode.6. The method of claim 1 , wherein the test strip comprises at least four electrodes.7. The method of claim 6 , wherein assigning a third electrode of the test strip to be the reference electrode during the first period and second period of ...

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Номер записи: 20
12-02-2015 дата публикации

POTENTIOSTAT REFERENCE ELECTRODE INTERFACE

Номер: US20150041336A1
Автор: Chan Wen
Принадлежит:

A method for shielding an electrical signal without substantially degrading the system speed or substantially increasing the bulk of the system is provided. The method includes applying a first signal to a conductor coupled to the electrode, applying a second signal to a shield substantially surrounding the conductor, blocking electrical interference to the first signal, and increasing an effective impedance on the electrode coupled to the conductor. The second signal may be a buffered and compensated version of the first signal. 1. A method implemented by a circuit for shielding an electrode from interference , the method comprising:applying a first signal to a conductor coupled to the electrode;applying a second signal to a shield substantially surrounding the conductor;blocking electrical interference to the first signal; andincreasing an effective impedance on the electrode coupled to the conductor.2. The method of claim 1 , wherein the second signal is a compensated version of the first signal.3. The method of claim 1 , wherein the second signal is buffered.4. The method of claim 1 , wherein the second signal is created using compensation circuitry.5. The method of claim 4 , wherein the compensation circuitry is configured to:measure the first signal on the conductor;amplify the first signal;remove at least one high frequency component from the first signal; andphase shift the first signal.6. The method of claim 1 , further comprising substantially reducing a potential difference between the conductor and the shield.7. The method of claim 6 , wherein substantially reducing a potential difference between the conductor and the shield comprises reducing the potential difference to approximately zero.8. The method of claim 1 , wherein the second signal is applied by a low impedance source.9. A method for detecting a target in a sample using a point-of-care diagnostic device claim 1 , wherein the diagnostic device includes a potentiostat that uses the method ...

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Номер записи: 21
11-02-2016 дата публикации

METHODS OF SCALING DATA USED TO CONSTRUCT BIOSENSOR ALGORITHMS AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

Номер: US20160041117A1
Автор: Buck, Carpenter Scott E., JR. Harvey B., Pan Zheng Zheng, Valverde-Ventura Rene
Принадлежит: ROCHE DIABETES CARE, INC.

Methods are disclosed for scaling body fluid analysis data to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature, variations in electrode conductivity or combinations thereof before providing an analyte concentration. The scaling methods utilize current response data obtained from an AC block applied prior to a DC block to minimize the impact of such confounding variables upon the observed DC current response before creating descriptors or algorithms. The scaling methods therefore compensate the measured DC current by using data from the AC block made on the same sample. Also disclosed are devices, apparatuses and systems incorporating the various scaling methods. 2. The method of claim 1 , wherein the AC block comprises a multi-frequency excitation waveform of at least two different frequencies.3. The method of claim 2 , wherein the frequencies are about 10 kHz claim 2 , about 20 kHz claim 2 , about 10 kHz claim 2 , about 2 kHz and about 1 kHz claim 2 , and wherein each is applied for about 0.5 sec to about 1.5 sec.4. The method of any of claim 1 , wherein the at least one DC block includes at least one pulse to about ten pulses at a potential that alternates between about 0 mV to about +450 mV claim 1 , and wherein each pulse is applied for about 50 msec to about 500 msec.5. The method of claim 4 , wherein each DC pulse at about +450 mV is applied for about 250 msec claim 4 , and each DC pulse at about 0 mV is applied for about 500 msec.6. The method of claim 1 , wherein the first constant and the second constant are a pre-determined median resistance value.7. The method of further comprising the step of estimating the analyte concentration based upon scaled amperometric data.8. The method of further comprising the step of providing a failsafe that incorporates Ras a parameter into a failsafe algorithm claim 1 , wherein the failsafe prevents reporting or displaying of the analyte concentration if the variations in electrode ...

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Номер записи: 22
09-02-2017 дата публикации

SYSTEM AND METHOD FOR COMPENSATING SAMPLE-RELATED MEASUREMENTS BASED ON POLARIZATION EFFECTS OF TEST STRIPS

Номер: US20170038331A1
Автор: MACFIE Gavin, McColl David
Принадлежит:

A system and a method for correcting an analyte concentration measurement taken by a test strip is described herein. The test strip includes at least two spaced apart electrodes defining an electrochemical cell or reaction chamber. An initial polarization parameter of the test strip is determined at the time of test strip manufacture and a testing polarization parameter is determined at the time of testing. A resulting correction factor is then determined based on the initial and testing polarization parameters. The correction parameter can be applied to a measured analyte concentration in order to correct the measured analyte concentration. 1. A method for determining an analyte concentration of a sample fluid applied to a test strip , the test strip comprising at least two electrodes in spaced relation and defining a reaction chamber , the method comprising:determining an initial polarization parameter of the test strip at a time of test strip manufacture;determining a testing polarization parameter of the test strip at a time of testing;determining a correction parameter of the test strip based on the initial polarization parameter and the testing polarization parameter;measuring an initial analyte concentration; andapplying the correction parameter to the initial analyte concentration to produce a corrected analyte concentration.2. The method of claim 1 , wherein the at least two electrodes comprise carbon screened electrodes to which an electrical potential can be applied in order to measure an analyte concentration.3. The method of claim 1 , in which measuring the initial analyte concentration comprises:applying an electrical test potential between the at least two electrodes;measuring a resulting current output in response to the applied electrical test potential; anddetermining the initial analyte concentration based on the current output.4. The method of claim 1 , wherein a polarization parameter is determined by applying a first potential between the at ...

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Номер записи: 23
08-02-2018 дата публикации

Blood component measuring device, method for measuring blood component, and bio-sensor

Номер: US20180038819A1
Автор: Masaki Fujiwara, Tomohiro Yamamoto
Принадлежит: Panasonic Healthcare Holdings Co Ltd

Provided is a blood component measuring device or the like that can further suppress the measurement error of a blood component. The device detects an oxidation-reduction current generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 of a biosensor 1 , and converts the oxidation-reduction current (glucose response value) into a glucose conversion value. The device detects a current generated when a second voltage is applied to a second electrode pair 23, 24 of the biosensor 1 , and converts the detected current (blood cell amount response value) into a blood cell amount conversion value. The glucose response value is measured more than once and the blood cell amount response value is also measured more than once within a predetermined period after the introduction of the blood into the biosensor 1 . A CPU 72 corrects the glucose conversion value measured within the predetermined period based on at least a part of a plurality of glucose conversion values and a plurality of blood cell amount conversion values obtained from the results of measurement.

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Номер записи: 24
06-02-2020 дата публикации

LIQUID SAMPLE MEASURING SYSTEM AND MEASURING DEVICE

Номер: US20200041436A1
Автор: NADAOKA Masataka, ODA Yoshimasa, SHINNO Teppei, TERASHIMA Noriyoshi
Принадлежит:

A liquid sample measuring system includes a measuring device including a measuring section which measures biological information from liquid sample of a living subject within a housing in which a biosensor, on which the liquid sample of the biological body is deposited, is detachably mounted and a movement measuring section which measures movement information of the housing within the housing, and an administrating device including a movement determining section which determines whether or not a degree of the movement of the housing is within an allowable range by analyzing the movement information received from the measuring device. 114-. (canceled)15. A liquid sample measuring device , comprising:a housing to which a biosensor on which a liquid sample of a living subject is deposited is detachably mounted;a measuring section configured to measure biological information from the liquid sample of the living subject, the measuring section disposed inside of the housing;a movement measuring section configured to measure movement information of the housing, the movement measuring section disposed inside the housing;a recording section configured to record identification information including at least one of identification of a measurer, identification of a subject person, and identification of the biosensor as measuring administration data;an input section to which the identification information and the movement instruction from the measurer are inputted;a display section configured to display the measuring administration data and information for the measurer;a control section configured to calculate consumption of the biosensor by extracting the identification of the biosensor from the measuring administration data.16. The liquid sample measuring device according to claim 15 , wherein:the measuring administration data includes at least one of a time of mounting the biosensor, a time of the sample deposition, a time of starting measuring and a time of ending measuring. ...

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Номер записи: 25
15-02-2018 дата публикации

LIQUID SAMPLE MEASURING SYSTEM AND MEASURING DEVICE

Номер: US20180045669A1
Автор: NADAOKA Masataka, ODA Yoshimasa, SHINNO Teppei, TERASHIMA Noriyoshi
Принадлежит:

A liquid sample measuring system includes a measuring device including a measuring section which measures biological information from liquid sample of a living subject within a housing in which a biosensor, on which the liquid sample of the biological body is deposited, is detachably mounted and a movement measuring section which measures movement information of the housing within the housing, and an administrating device including a movement determining section which determines whether or not a degree of the movement of the housing is within an allowable range by analyzing the movement information received from the measuring device. 1. A liquid sample measuring device , comprising:a housing to which a biosensor on which a liquid sample of a living subject is deposited is detachably mounted;a measuring section configured to measure biological information from the liquid sample of the living subject, the measuring section disposed inside of the housing;a movement measuring section configured to measure movement information of the housing, the movement measuring section disposed inside the housing;a movement determining section configured to analyze the movement information and determine whether a degree of movement is within an allowable range; anda display section configured to display an instruction program that instructs a user how to handle the housing,wherein the display section displays the instruction program according to a result of determining by the movement determining section before the measuring section measures the biological information and/or after the measuring section measures the biological information.2. The liquid sample measuring device according to claim 1 , wherein:the movement determining section is further configured to determine whether the degree of the movement of the housing during a time from when the biosensor is mounted to the housing to when measuring the biological information by the measuring section ends.3. The liquid sample ...

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Номер записи: 26
26-02-2015 дата публикации

ELECTROCHEMICAL TEST SENSOR AND METHOD OF MAKING THE SAME

Номер: US20150052746A1
Автор: Lieber Harris A., Perry Joseph E.
Принадлежит:

An electrochemical test sensor being adapted to assist in determining information relating to an analyte in a fluid sample and includes a base and a second layer. The base includes a plurality of electrodes, a working conductive lead and a counter conductive lead thereon. The electrodes include a working electrode and a counter electrode. The second layer assists in forming a channel in which the channel includes a reagent therein. Auto-calibration information of the test sensor is performed by a plurality of auto-calibration segments connected to one of the following: the working conductive lead, the counter conductive lead, or neither of the conductive leads, at least one of the plurality of auto-calibration segments being connected to the working conductive lead and at least one of the plurality of auto-calibration segments being connected to the counter conductive lead. 119-. (canceled)20. A method of making an electrochemical test sensor adapted to assist in determining information relating to an analyte in a fluid sample , the method comprising the acts of:providing a base;providing a second layer to assist in forming a channel;providing a plurality of electrodes on the base, the plurality of electrodes including a working electrode and a counter electrode;providing a working conductive lead that is electrically connected to the working electrode;providing a counter conductive lead that is electrically connected to the counter electrode;providing a reagent formed in the channel; andproviding information of the test sensor by forming a plurality of information segments to be connected to one of the following: the working conductive lead, the counter conductive lead, or neither of the conductive leads, and wherein at least one of the plurality of information segments is connected to the working conductive lead and at least one of the plurality of information segments is connected to the counter conductive lead;wherein each of a first plurality of information ...

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Номер записи: 27
21-02-2019 дата публикации

Method of operation of a meter

Номер: US20190056345A1
Автор: Chen Wen-Huang, Lee Cheng-Che
Принадлежит:

The method of operation of a meter includes placing a sample on a test strip, assigning a first electrode of the test strip to be a counter electrode, applying a first signal to the test strip during a first period of time, assigning a second electrode of the test strip to be the counter electrode, applying a second signal to the test strip to measure the concentration of an analyte in the sample. 1. A method of operation of a meter to measure a response of a sample on a reaction chamber of a test strip , comprising:assigning a first electrode of the test strip to be a counter electrode;applying a first signal to a working electrode of the test strip during a first period of time;assigning a second electrode of the test strip to be the counter electrode;applying a second signal to the working electrode of the test strip during a second period of time; andmeasuring the response during the second period of time.2. The method of claim 1 , wherein assigning the first electrode of the test strip to be the counter electrode and assigning the second electrode of the test strip to be the counter electrode is performed using at least one switch of the meter.3. The method of claim 1 , further comprising assigning the first electrode of the test strip to be a reference electrode before applying the second signal to the working electrode of the test strip during the second period of time.4. The method of claim 1 , further comprising assigning the second electrode of the test strip to be a reference electrode before applying the first signal to the working electrode of the test strip during the first period of time.5. The method of claim 1 , wherein said the response is measuring a current across the working electrode and the second electrode.6. The method of claim 1 , wherein the test strip comprises at least four electrodes.7. The method of claim 6 , wherein assigning a third electrode of the test strip to be the reference electrode during the first period and second period of ...

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Номер записи: 28
21-02-2019 дата публикации

Measuring Method and Measuring Apparatus

Номер: US20190056346A1
Автор: Kaneda Hisashi, Nakatani Ayano
Принадлежит: ARKRAY, INC.

A measuring method includes applying a first signal, which is a direct current signal, having a first value to a sample in a flow passage using a first electrode and a fourth electrode which is different from the first, second, and third electrodes, measuring a first electric response value, applying a second signal having a second value higher than the first value to the sample using the second and third electrodes, measuring a second electric response value, and correcting a value obtained from the first electric response value based on the second electric response value. 1. A measuring method for measuring a target substance contained in a sample by using an analysis tool including a flow passage for the sample and a plurality of electrodes arranged in the flow passage , the measuring method comprising:the plurality of electrodes including a first electrode which is provided with a reagent including an enzyme, a second electrode and a third electrode each of which is not provided with the reagent, and a fourth electrode which is different from the first electrode, the second electrode, and the third electrode,applying a first signal, which is a direct current signal, having a first value to the sample in the flow passage by using the first electrode as a working electrode and using the fourth electrode as a counter electrode;measuring a first electric response value of the sample to the first signal;applying contiguously for a given time a second signal, which is a direct current signal, having a second value higher than the first value to the sample in the flow passage by using the second electrode and the third electrode as the working electrode and the counter electrode;measuring a second electric response value of the sample within the given time to the second signal, the second electric response value indicating amount of electric charge generated by electrolysis of water in the sample; andcorrecting a value obtained from the first electric response value ...

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Номер записи: 29
21-02-2019 дата публикации

Measuring Method and Measuring Apparatus

Номер: US20190056347A1
Автор: Kaneda Hisashi, Nakatani Ayano
Принадлежит: ARKRAY, INC.

A measuring method includes applying a first signal having a first value to a sample disposed in the flow passage by using a working electrode and a counter electrode, measuring a first electric response value of the sample to the first signal, applying contiguously for a given time a second signal having a second value higher than the first value to the sample disposed in the flow passage by using the working electrode and the counter electrode, measuring a second electric response value of the sample within the given time to the second signal, the second electric response value indicating amount of electric charge generated by electrolysis of water in the sample, and correcting a value obtained from the first electric response value based on the second electric response value. 1. A measuring method for measuring a target substance contained in a sample by using an analysis tool in which at least one working electrode provided with a reagent including an enzyme and at least one counter electrode are arranged in a flow passage , the measuring method comprising:applying a first signal, which is a direct current signal, having a first value to the sample disposed in the flow passage by using the working electrode and the counter electrode;measuring a first electric response value of the sample to the first signal;applying contiguously for a given time a second signal, which is a direct current signal, having a second value higher than the first value to the sample disposed in the flow passage by using the working electrode and the counter electrode;measuring a second electric response value of the sample within the given time to the second signal, the second electric response value indicating amount of electric charge generated by electrolysis of water in the sample; andcorrecting a value obtained from the first electric response value based on the second electric response value.2. The measuring method according to claim 1 , wherein the counter electrode claim 1 , ...

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Номер записи: 30
12-03-2015 дата публикации

FILL SUFFICIENCY METHOD AND SYSTEM

Номер: US20150068920A1
Автор: CARDOSI Marco F., LEACH Christopher Philip, MILLS Leanne, Moffat James, RODGERS James Iain
Принадлежит:

Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip. 1. A method of determining the volume sufficiency of a fluid sample applied to a test strip electrically connected to a meter for measuring a glucose concentration , the method comprising:applying a first voltage between a first working electrode coated with a first reagent layer disposed on a mediator layer, a shared reference electrode coated with a mediator layer and a second working electrode coated with a second reagent layer disposed on a mediator layer;measuring a current during the first time period at the first working electrode;applying a voltage other than first voltage for a second time period after the first time period between the reference electrode and the second working electrode;measuring a current during the second time period at the second working electrode with the meter;predicting an estimated second current during the second time period at the second working electrode;evaluating a difference between the measured second current during the second time period and the estimated second current during the second time period at the second working electrode; anddisplaying an error condition indicating ...

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Номер записи: 31
12-03-2015 дата публикации

BIOSENSOR MONITORS, TEST STRIPS AND ACTIVATION MECHANISMS AND METHODS THEREOF

Номер: US20150068923A1
Автор: Huang Kuan-Chih, LEE JEN-FANG
Принадлежит:

The disclosure is directed to biosensor monitors, test strips and activation mechanisms and methods thereof. The biosensor monitor is for verifying a test strip to be used with the biosensor monitor. The monitor includes verification components located within the monitor and accessible to a test strip to be inserted into the biosensor monitor. The verification components interact with verification portions of the test strip to allow the biosensor monitor to verify the test strip before the biosensor monitor tests biological material on the test strip. A test strip and methods are also described. 1. A method for verifying a test strip comprising:sensing a presence of a test strip in a biosensor monitor;receiving a signal at one or more verification components of the biosensor monitor from one or more verification portions of the test strip;verifying the identity of the test strip.2. The method of claim 1 , wherein the verification portions of the test strip comprise conductive pads and the method further comprising applying a plurality of different electrical potentials to the conductive pads of the test strip.3. The method of claim 2 , wherein applying the plurality of different electrical potentials comprises applying different combinations of the plurality of different electrical potentials to the one or more verification portions of the test strip.4. The method of claim 2 , wherein the one or more verification portions comprise a plurality of verification portions and applying the plurality of different electric potentials comprises applying different combinations of the plurality of different electrical potentials to the plurality of verification portions of the test strip.5. The method of claim 1 , wherein light is emitted from the one or more verification component of the biosensor and light reflected off of the one or more verification portions of the test strip is detected claim 1 , wherein at least a portion of the one or more verification portions comprise ...

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Номер записи: 32
17-03-2016 дата публикации

APPARATUS AND METHOD FOR MEASURING CONCENTRATION OF WHOLE BLOOD SAMPLES

Номер: US20160077037A1
Автор: Cha Geun Sig, CHO Sung Pil, CHOI Sung Hyuk, KANG Youngjea, LEE Myeongho, Lee Seok-Won, Nam Hakhyun, PARK Ho Dong
Принадлежит:

A method for measuring a concentration of an analyte in a bio-sample using an electrochemical bio-sensor according to an exemplary embodiment of the present invention is characterized by a step of obtaining predetermined features from induced currents obtained by applying a DC voltage according to chronoamperometry in which, after a whole blood sample is injected to the electrochemical bio-sensor, a concentration of an analyte is obtained from an induced current obtained by applying a DC voltage for a certain time and from all induced currents obtained by further applying several step-ladder perturbation potentials for a short time subsequent to the DC voltage for the certain time, and is also characterized by minimization of a measurement error caused by a hindering material by forming a calibration equation by combining the at least one feature in a function and optimizing various conditions of the bio-sample through Deleted Texts multivariable analysis. 1. A method for measuring a concentration of an analyte in a bio-sample , the method comprising:a step of introducing a liquid bio-sample into a sample cell in which an oxidation/reduction enzyme capable of catalyzing an oxidation/reduction reaction of the analyte and an electron transfer mediator are fixed and a working electrode and an counter electrode are provided;a step of obtaining a first induced current by applying a constant DC voltage to the working electrode to start the oxidation/reduction reaction of the analyte and proceed with an electron transfer reaction;{'img': {'@id': 'CUSTOM-CHARACTER-00012', '@he': '3.13mm', '@wi': '2.12mm', '@file': 'US20160077037A1-20160317-P00002.TIF', '@alt': 'custom-character', '@img-content': 'character', '@img-format': 'tif'}, 'a step of obtaining a second induced current by applying a -step ladder-type perturbation potential after applying the constant DC voltage;'}a step of calculating a predetermined feature from two or more characteristic points from the first ...

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Номер записи: 33
17-03-2016 дата публикации

EXAMINATION METHOD FOR DETECTING ABNORMAL ELECTROCHEMICAL TESTING STRIP

Номер: US20160077038A1
Автор: LIAO Hung-Yun, TSAI Tsung-Hsuan, WENG Chih-Wei, YEN Miao-Ju
Принадлежит:

An examination method for detecting abnormal electrochemical testing strip includes the steps of: applying a trigger voltage to a testing strip; injecting a target sample to the testing strip; obtaining a trigger current which is generated by injecting the target sample to the testing strip; comparing the trigger current with a first threshold, and determining whether the trigger current is lager than or equal to the first threshold; and when the trigger current is less than the first threshold, displaying a message for abnormality. 1. An examination method for detecting abnormal electrochemical testing strip , comprising steps of:applying a trigger voltage to a testing strip;injecting a target sample to the testing strip;obtaining a trigger current which is generated by injecting the target sample to the testing strip;comparing the trigger current with a first threshold, and determining whether the trigger current is lager than or equal to the first threshold; andwhen the trigger current is less than the first threshold, displaying a message for abnormality.2. The examination method as recited in claim 1 , wherein the step of determining whether the trigger current is lager than or equal to the first threshold enters into a reaction stage when the trigger current is larger than or equal to the first threshold.3. The examination method as recited in claim 2 , wherein the reaction stage indicates the stage when the target sample generates the electrochemical reaction claim 2 , and a first driving voltage is supplied in the reaction stage to obtain a first reading current.4. The examination method as recited in claim 3 , further comprising steps of:supplying the first driving voltage to the testing strip and then resting the testing strip for a time interval to obtain a second reading current;comparing the ratio of the first reading current to the second reading current with a second threshold to determine whether the ratio is larger than or equal to the second ...

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Номер записи: 34
17-03-2016 дата публикации

APPARATUS FOR DIAGNOSTIC METER STRIP CONTROL AND IDENTIFICATION

Номер: US20160077039A1
Автор: Combs Brad, Leone Steven V., Modzelewski Brent E.
Принадлежит:

A system for measuring a property of a sample in a liquid which includes a test strip and a meter is provided. Some embodiments relate to a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, the control circuit configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; and a diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit. 1. A system for measuring a property of a sample in a liquid , comprising:a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; anda diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit.2. The system according to claim 1 , wherein the control circuit comprises a non-volatile string of bits used to identify the strip as authentic.3. The system according to claim 1 , wherein the control circuit comprises a non-volatile string of bits used as lot codes.4. The system according to claim 1 , wherein the controller of the meter is further programmed to perform a test utilizing the test strip and to inhibit the test strip after the test has been completed.5. The system according to claim 1 , wherein the control circuit is configured to measure a temperature of ...

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Номер записи: 35
17-03-2016 дата публикации

METHOD OF MEASURING BLOOD COMPONENT, SENSOR USED IN THE METHOD, AND MEASURING DEVICE

Номер: US20160077040A1
Автор: FUJIWARA Masaki, IKEDA Shin, SHINNO Teppei
Принадлежит:

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The method of measuring a component in blood using a biosensor comprising a first electrode system including a first working electrode on which at least an oxidoreductase that acts upon the component and a mediator are provided and a first counter electrode and a second working electrode on which the mediator is not provided. The first working electrode and the first counter electrode are used for obtaining the amount of the component and the second working electrode and the first working electrode are used for obtaining the amount of the blood cells. 143-. (canceled)44. A method of determining an amount of a component in blood using a biosensor comprising a first electrode , a second electrode , and a reagent layer comprising a mediator and an oxidoreductase , said reagent layer disposed on the second electrode;the method comprising:applying a first voltage to the first electrode and a second voltage to the second electrode such that the first electrode acts as a working electrode and the second electrode acts as a counter electrode;detecting a first current value generated by the application of the first voltage and the second voltage;applying a third voltage to the second electrode such that the second electrode acts as a working electrode; anddetecting a second current value generated by the application of the third voltage.; andcalculating an amount of the component using the first current value and the second current value.45. The method of claim 44 , wherein the reagent layer is not disposed on the first electrode.46. The method of claim 44 , wherein the second electrode has a negative polarity when it acts as a counter electrode.47. The method of claim 44 , wherein the second electrode ...

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Номер записи: 36
17-03-2016 дата публикации

Underfill Management System For A Biosensor

Номер: US20160077050A1
Автор: Eric A. Maurer, Huan-Ping Wu
Принадлежит: Ascensia Diabetes Care Holdings AG

A biosensor system including the underfill management system determines the analyte concentration in a sample from the at least one analytic output signal value. The underfill management system includes an underfill recognition system and an underfill compensation system. The underfill recognition system determines whether the test sensor initially is substantially full-filled or underfilled, indicates when the sample volume is underfilled so that additional sample may be added to the test sensor, and starts or stops the sample analysis in response to the sample volume. The underfill recognition system also may determine the initial degree of underfill. After the underfill recognition system determines the initial fill state of the test sensor, the underfill compensation system compensates the analysis based on the initial fill state of the test sensor to improve the measurement performance of the biosensor system for initially underfilled test sensors.

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Номер записи: 37
15-03-2018 дата публикации

TEMPERATURE COMPENSATION FOR AN ANALYTE MEASUREMENT DETERMINED FROM A SPECIFIED SAMPLING TIME DERIVED FROM A SENSED PHYSICAL CHARACTERISTIC OF THE SAMPLE CONTAINING THE ANALYTE

Номер: US20180074008A1
Автор: Malecha Michael
Принадлежит:

Various embodiments for a method, systems and meters that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and compensating for the effects of ambient temperature with a defined relationship between temperature in the environment, the meter or the biosensor. 1applying a signal to the at least two electrodes;initiating an electrochemical reaction between the at least two electrodes and an analyte in a fluid sample to cause a transformation of the analyte into a byproduct;measuring a signal output from the at least two electrodes during the electrochemical reaction;measuring a temperature proximate the biosensor;calculating an analyte value representative of a quantity of analyte in the fluid sample from the signal output; (a) the temperature compensation term increases for increasing analyte values; and', '(b) the temperature compensation term is inversely related to the biosensor temperature in a range of about 5 degrees Celsius to about 22 degrees Celsius;', '(c) the temperature compensation term is about zero for the ambient temperature proximate the biosensor from about 22 degrees Celsius to about 45 degrees Celsius;, 'adjusting the analyte value to a final analyte value by a temperature compensation term defined by a relationship whereandannunciating the final value representative of the quantity of analyte in the fluid sample.. A method of adjusting for the effect of temperature upon a biosensor having a plurality of electrodes with at least two electrodes provided with enzymes thereon, the method comprising the steps of: This DIVISIONAL application claims the benefits of priority under 35 USC §§ 120 and 121 from prior filed U.S. application Ser. No. 13/929,495 filed on Jun. 27, 2013, allowed, which prior filed application (Ser. No. 13/929,495) claims the benefits under 35 USC §§ 119 and 120 of prior filed U.S. Provisional Application Ser. No. 61/840,176 filed on Jun. 27, 2013, ...

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Номер записи: 38
18-03-2021 дата публикации

OPERATION AND VERIFICATION OF A PORTABLE CLINICAL ANALYSIS SYSTEM

Номер: US20210080449A1
Автор: Davis Graham, Emeric Pierre, Fetters Christopher, Soman Narendra, Vandersleen Gary, Wasserman Paul
Принадлежит: ABBOTT POINT OF CARE INC.

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A portable clinical system for in vitro analysis , the portable clinical system comprising:a cartridge configured to perform an in vitro analytical test; and a port configured to receive the cartridge,', 'a measurement module interfacing with the cartridge inserted into the port, the measurement module configured to perform a test cycle on the cartridge to conduct the in vitro analytical test on a sample, thereby generating a vibration profile for the test cycle of the cartridge; and', compare the generated vibration profile for the test cycle of the cartridge with a pre-established vibration profile,', 'determine whether the generated vibration profile for the test cycle of the cartridge deviates from the pre-established vibration profile, and', 'based on the comparison of the test cycle of the cartridge with the pre-established vibration profile, indicate whether the analyzer is functioning properly., 'a computing device configured to], 'an analyzer comprising'}2. The portable clinical system of claim 1 , wherein the pre-established vibration profile is a typical vibration profile for a similar cartridge.3. The portable clinical system of claim 1 , wherein the vibration profile for the test cycle of the cartridge comprises vibration from movement of one of more plungers of the analyzer when the analyzer performs the test cycle on the cartridge.4. The portable clinical system of claim 1 , wherein the vibration profile for the test cycle of the cartridge comprises acceptable variation from the pre-established vibration profile.5. The portable clinical system of claim 1 , wherein the computing device is ...

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Номер записи: 39
12-06-2014 дата публикации

METHOD OF MEASURING BLOOD COMPONENT, SENSOR USED IN THE METHOD, AND MEASURING DEVICE

Номер: US20140158553A1
Автор: FUJIWARA Masaki, IKEDA Shin, SHINNO Teppei
Принадлежит: Panasonic Corporation

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The method of measuring a component in blood using a biosensor comprising a first electrode system including a first working electrode on which at least an oxidoreductase that acts upon the component and a mediator are provided and a first counter electrode and a second working electrode on which the mediator is not provided. The first working electrode and the first counter electrode are used for obtaining the amount of the component and the second working electrode and the first working electrode are used for obtaining the amount of the blood cells. 143-. (canceled)44. A method of measuring a component in blood using a biosensor comprising a first electrode system including a first working electrode on which at least an oxidoreductase that acts upon the component and a mediator are provided and a first counter electrode and a second working electrode on which the mediator is not provided , the method comprising:a first step of obtaining a first current value by applying a first voltage to the first working electrode as a working electrode and the first counter electrode as a counter electrode; anda second step of obtaining a second current value by applying a second voltage to the second working electrode as a working electrode and the first working electrode as a counter electrode,wherein the first current value contains information on the amount of the component,the second current value contains information related to an amount of blood cells in the blood, andthe first current value and the second current value are used to calculate a value of the amount of the component, corrected based on the amount of blood cells.45. The method according to claim 44 , wherein the first step is carried ...

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Номер записи: 40
22-03-2018 дата публикации

SENSOR WITH MULTIPLE INLETS

Номер: US20180080894A1
Автор: Brown Michael Alvin, Davis Brian Keith, SR. Mark Flori, Zanella
Принадлежит:

An electrochemical gas sensor includes a sensor housing having a plurality of inlet passages, wherein each of the plurality of inlet passages has a cross-sectional area of no greater than 11,309 μm. The electrochemical gas sensor further includes a working electrode within the housing which is responsive to an analyte gas and an electrolyte within the sensor housing in ionic contact with the working electrode. 1. An electrochemical gas sensor , comprising:{'sup': '2', 'a sensor housing comprising a plurality of inlet passages, each of the plurality of inlet passages having a cross-sectional area of no greater than 11,309 μm;'}a working electrode within the housing which is responsive to an analyte gas; andan electrolyte within the sensor housing in ionic contact with the working electrode.2. The electrochemical sensor of wherein each of the plurality of inlet passages has a cross-sectional area of no greater than 2827 μm.3. The electrochemical sensor of wherein each of the plurality of inlet passages has a cross-sectional area of no greater than 1257 μm.4. The electrochemical sensor of wherein a cumulative geometric area of the plurality of inlet passages is in the range of 0.25 mmto 2.25 mm.5. The electrochemical sensor of wherein the sensor is adapted to detect concentration changes of the analyte gas on the order of 5000 ppm or less.6. The electrochemical sensor of wherein the electrochemical sensor is adapted to detect concentration changes of the analyte gas on the order of 1000 ppm or less.7. The electrochemical sensor of wherein the electrochemical sensor is adapted to detect concentration changes of the analyte gas on the order of 100 ppm or less.8. The electrochemical sensor of wherein the electrochemical sensor is adapted to detect changes in concentration of an analyte gas other than oxygen.9. The electrochemical sensor of wherein the electrolyte is hygroscopic.10. The electrochemical sensor of wherein the electrolyte comprises an aqueous acidic solution. ...

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Номер записи: 41
24-03-2016 дата публикации

ELECTRODE REACTION AREA TESTING METHOD OF BIOSENSOR TEST STRIP

Номер: US20160084793A1
Автор: CHANG YI CHUNG, CHEN YI LUNG, JIANG FANG YI, LAI CHIEN HUNG, LIN YA SIAN, YU CHIH CHUN
Принадлежит:

An electrode reaction area testing method of biosensor test strip includes: (1) preparing a semi-finished or finished test strip product having at least one sensing window corresponding to an electrode reaction area; a plural electrodes exposed from the electrode reaction area; (2) detecting the electrode reaction current of the electrode reaction area to obtain a first electrode reaction current and a third electrode reaction current; (3) calculating a current ratio of the first electrode reaction current to the third electrode reaction current; (4) determining the current ratio; (5) completing the detection of the electrode reaction area to determine whether the semi-finished or finished test strip product is good or defective, so as to test the accuracy of the separating plate attaching position or the insulating position and the applicability of the electrode reaction area in the manufacture of the test strip. 1. An electrode reaction area testing method of biosensor test strip , comprising the steps of:preparing a semi-finished or finished test strip product having a substrate and a separating plate, wherein the separating plate has a sensing window, the substrate has a first electrode, a second electrode and a third electrode disposed on a side of the sensing window and sequentially arranged from the outside to the inside; an end of the first electrode proximate to the sensing window is a first reacting electrode, an end of the second electrode proximate to the sensing window is a second reacting electrode, an end of the third electrode proximate to the sensing window is a third reacting electrode; covering the separating plate onto the first electrode, the second electrode and the third electrode; aligning the sensing window with the first reacting electrode, the second reacting electrode and the third reacting electrode, wherein each of the first reacting electrode, the second reacting electrode and the third reacting electrode has a partial area exposed ...

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Номер записи: 42
31-03-2016 дата публикации

ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP TO DETERMINE ANALYTE MEASUREMENT TIME BASED ON MEASURED TEMPERATURE, PHYSICAL CHARACTERISTIC AND ESTIMATED ANALYTE VALUE

Номер: US20160091451A1
Автор: McColl David, Smith Antony
Принадлежит:

Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic signal representative of the sample containing the analyte and selecting an analyte measurement sampling time based on measured temperature, physical characteristic and estimated analyte values. 1. An analyte measurement system comprising: a substrate;', 'a plurality of electrodes connected to respective electrode connectors; and, 'a test strip including a housing;', 'a test strip port connector configured to connect to the respective electrode connectors of the test strip; and', 'a microprocessor in electrical communication with the test strip port connector to apply electrical signals or sense electrical signals from the plurality of electrodes during a test sequence,, 'an analyte meter including (a) start an analyte test sequence upon deposition of a sample;', '(b) apply a signal to the sample to determine a physical characteristic signal representative of the sample;', '(c) drive another signal to the sample;', '(d) measure at least one output signal from at least one of the electrodes;', '(e) measure a temperature of one of the sample, test strip, or meter;', '(f) determine a temperature compensated value for the physical characteristic signal based on the measured temperature;', '(g) derive an estimated analyte concentration from the at least one output signal at one of a plurality of predetermined time intervals as referenced from the start of the test sequence;', '(h) determine a temperature compensated value for the estimated analyte concentration based on the measured temperature;', '(i) select an analyte measurement sampling time point or time interval with respect to the start of the test sequence based on (1) the temperature compensated value of the physical characteristic signal and (2) the temperature compensated value of the estimated analyte concentration;', '(j) calculate an analyte concentration ...

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Номер записи: 43
31-03-2016 дата публикации

Measurement Method Using Oxidase

Номер: US20160091452A1
Автор: Kaneda Hisashi
Принадлежит: ARKRAY, INC.

A method for measuring a target object in a sample by using an oxidase, wherein the influence of dissolved oxygen in the sample can be corrected, is provided. The method comprises: obtaining measurement values by causing the target object in the sample to react with the oxidase under different conditions of two or more types; and performing a correction based on the obtained two or more measurement values and a correction method preliminarily set so as to correct the influence of dissolved oxygen in the sample. 15-. (canceled)6. A measurement device comprising:a sensor section for obtaining information about measurement results obtained from reactions between a target object in a sample and an oxidase under different conditions of two or more types;a memory section for storing a correction method;an arithmetic section for selecting the correction method stored in the memory section based on the information obtained by the sensor section, and calculating a corrected value of the information by the correction method;and a display section for displaying the corrected value.7. The measurement device according to claim 6 , wherein the target object is selected from the group consisting of glucose claim 6 , lactic acid claim 6 , bilirubin claim 6 , cholesterol and ascorbic acid.8. The measurement device according to claim 6 , wherein the target object is glucose.9. The measurement device according to claim 6 , wherein the oxidase is selected from the group consisting of glucose oxidase claim 6 , lactate oxidase claim 6 , bilirubin oxidase claim 6 , cholesterol oxidase claim 6 , ascorbic acid oxidase claim 6 , uric acid oxidase claim 6 , peroxidase claim 6 , sulfurous acid oxidase claim 6 , amine oxidase claim 6 , lysyl oxidase claim 6 , lysine oxidase claim 6 , amino acid oxidase claim 6 , diamine oxidase claim 6 , pyridoxine phosphate oxidase claim 6 , protein-lysine 6-oxidase claim 6 , acyl-CoA oxidase claim 6 , alcohol oxidase claim 6 , choline oxidase claim 6 , ...

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Номер записи: 44
31-03-2016 дата публикации

METHOD FOR MEASURING HEMATOCRIT VALUE OF BLOOD SAMPLE, METHOD FOR MEASURING CONCENTRATION OF ANALYTE IN BLOOD SAMPLE, SENSOR CHIP AND SENSOR UNIT

Номер: US20160091453A1
Автор: FUJIWARA Masaki, IKEDA Shin, NAKAMINAMI Takahiro
Принадлежит:

Provided is a sensor chip for electrochemically measuring a concentration of an analyte in a blood sample. In one embodiment of the sensor, the sensor chip includes a substrate, and a preliminary measurement analyzer and a hematocrit value analyzer disposed on the substrate. The preliminary measurement analyzer includes a preliminary working electrode and a preliminary counter electrode. The hematocrit value analyzer includes a working electrode and a counter electrode. An oxidant of a redox substance is disposed on the preliminary measurement analyzer and the counter electrode. A reductant of a redox substance is disposed on the working electrode. 114-. (canceled)15. A method of determining an amount of a component in blood using a biosensor , a first electrode,', 'a second electrode,', 'an oxidant of a redox substance, and', 'a reductant of a redox substance,', 'wherein the reductant of a redox substance is disposed on the first electrode, and', 'the oxidant of a redox substance is disposed on the second electrode;, 'the biosensor comprising the method comprising:applying a first voltage to the first electrode and a second voltage to the second electrode such that the first electrode acts as a working electrode and the second electrode acts as a counter electrode;detecting a first current value generated by the application of the first voltage and the second voltage;applying a third voltage to the second electrode such that the second electrode acts as a working electrode;detecting a second current value generated by the application of the third voltage.; andcalculating an amount of the component using the first current value and the second current value.16. The method of claim 15 , wherein the first voltage and the second voltage are applied for a time of 0.01 to 10 seconds.17. The method of claim 15 , wherein the third voltage is applied for a time of 0.1 to 10 seconds.18. The method of claim 15 , wherein the amount of the component is calculated taking into ...

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Номер записи: 45
31-03-2016 дата публикации

OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS

Номер: US20160091454A1
Автор: Beer Greg P., Wu Huan-Ping
Принадлежит:

Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. 1. A method of distinguishing a control solution from a biological sample during operation of an electrochemical sensor measuring the amount of an analyte in said control solution and in said biological sample , the method comprising the acts of:(a) adding to said control solution an internal reference compound, said compound being adapted to be electrochemically oxidized at a potential higher than the potential needed to measure the oxidation of said analyte, said internal reference compound being added in an amount relative to a predetermined amount of analyte in said control solution sufficient to indicate the presence of said internal reference compound in the control solution;(b) introducing said control solution containing said internal reference compound and said predetermined amount of said analyte to an electrochemical sensor, said sensor having working and reference electrodes and a reaction layer containing reagents for oxidizing said analyte;(c) at least once applying a potential to said electrodes of said electrochemical sensor sufficient to oxidize said internal reference compound and said analyte and measuring the resulting electrical current;(d) at least once applying a potential to said electrochemical sensor lower than the potential of (c), said potential being sufficient to measure oxidation of said analyte and not sufficient to oxidize said internal reference compound and measuring the resulting electrical current;{'sub': high ...

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Номер записи: 46
26-03-2020 дата публикации

ELECTRODE BREAK DETECTION

Номер: US20200096471A1
Автор: Beaty Terry A., Wheeler Michael Harrison
Принадлежит: ROCHE DIABETES CARE, INC.

A method and system for determining a failsafe value for a biosensor having two perimeter electrodes, a distal electrode, and a proximal electrode are disclosed. A liquid measuring medium is applied to a capillary channel of the biosensor. The method includes applying an alternating voltage to the perimeter electrode and the proximal electrode, measuring conductivity to determine a first impedance between the perimeter electrode and the proximal electrode, applying the alternating voltage to the perimeter electrode and the distal electrode, measuring conductivity to determine a second impedance between the perimeter electrode and the distal electrode, determining a value using the first impedance and the second impedance, and providing an error message to the user if the value is out of tolerance. If the value is out of tolerance, then defects or breaks in the electrodes and/or reagent in a reaction area are present and the method disallows the test result. 1. A method for error checking a biosensor , comprising:applying a liquid measuring medium to a perimeter electrode, a proximal electrode, and a distal electrode on the biosensor;applying an alternating voltage to the perimeter electrode and the proximal electrode;measuring conductivity which is used to determine a first impedance between the perimeter electrode and the proximal electrode;applying said alternating voltage to the perimeter electrode and the distal electrode;measuring conductivity which is used to determine a second impedance between the perimeter electrode and the distal electrode;determining a value using the first impedance and the second impedance; andproviding an error message if the value is out of tolerance.2. The method according to claim 1 , wherein the perimeter electrode is a sample sufficiency counter electrode.3. The method according to claim 1 , wherein the perimeter electrode is a sample sufficiency working electrode.4. The method according to claim 1 , wherein the proximal electrode ...

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Номер записи: 47
18-04-2019 дата публикации

Analyte Detection Meter and Associated Method of Use

Номер: US20190113498A1
Автор: Cai Kevin, Harding Ian, Iyengar Sridhar, Williams Richard
Принадлежит: AGAMATRIX, INC.

A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample. 126.-. (canceled)28. The method of claim 27 , wherein the characteristic information is information reflecting a characteristic of the test strip at the time of manufacture of the test strip.29. The method of claim 27 , wherein the characteristic information encoded on the strip is information selected from the group consisting of: calibration information claim 27 , regional or country coding claim 27 , product identification claim 27 , customer identification claim 27 , assay type claim 27 , and date of manufacture.30. The method of claim 27 , wherein the method comprises the step of controlling or altering the effective area of an electrode within the sample space of the test strip claim 27 , wherein a two-dimensional surface area of the electrode is controlled or altered.31. The method of claim 30 , wherein a three-dimensional surface area is controlled or altered.32. The method of claim 27 , wherein the method comprises the step of controlling or altering the effective area of an electrode within the sample space of the test strip claim 27 , wherein a three-dimensional effective electrode area is controlled or altered.33. The method of claim 27 , wherein the method comprises the step of controlling or altering the surface of an electrode within the sample space claim 27 , wherein ...

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Номер записи: 48
24-07-2014 дата публикации

Electrochemical Biosensor

Номер: US20140202881A1
Автор: Charlton Steven C., Edelbrock Andrew J., George Suny J., Huang Dijia
Принадлежит: Bayer HealthCare LLC

According to one embodiment of the present invention, an electrochemical sensor () for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor () includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor. 135-. (canceled)36. An electrochemical sensor for detecting the concentration of an analyte in a fluid test sample , the sensor comprising:a flow path for receiving the fluid test sample;a plurality of leads each configured to be electrically coupled with a detector of electrical current;a working electrode disposed along the flow path and in electrical communication with at least one of the plurality of leads;a counter electrode disposed along the flow path and in electrical communication with at least one of the plurality of leads;a resistor in electrical communication with at least one of the plurality of leads; anda reagent disposed on at least the working electrode, the reagent being configured to react with the analyte to produce electrons that are transferred to the working electrode.37. The electrochemical sensor of claim 36 , wherein the counter electrode includes a high-resistance portion and a low-resistance portion claim 36 , the high resistance portion including the resistor.38. The electrochemical sensor of claim 37 , wherein the high-resistance portion of the counter electrode is located upstream along the flow path relative to the working electrode and the low-resistance portion of the counter electrode is located downstream along the flow path relative to the working electrode.39. The electrochemical sensor of claim 37 , wherein the reagent is further disposed over low-resistance portion of the counter electrode.40. The electrochemical sensor of claim 39 , wherein the reagent is also further disposed over the high-resistance portion of the counter electrode.41. The electrochemical test sensor of claim 36 , wherein ...

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Номер записи: 49
14-05-2015 дата публикации

SYSTEMS AND METHODS FOR IMPROVED STABILITY OF ELECTROCHEMICAL SENSORS

Номер: US20150129424A1
Автор: Chatelier Ronald C., Hodges Alastair M.
Принадлежит:

Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a measurement of a parameter correlating to changes in a physical property of the sample analyzing device is calculated. A concentration of the analyte in view of the parameter correlating to a change in the physical property can then be determined. Systems and devices that take advantage of the parameter correlating to changes in a physical property to make analyte concentration determinations are also provided. 1. An electrochemical system , comprising:an electrochemical cell having a first electrode and a second electrode;a meter including a control unit connected to the electrochemical cell so that the control unit applies a potential between the first electrode and the second electrode of the electrochemical cell andthe control unit determines a measurement of a parameter correlating to a physical property of the electrochemical cell and uses said measurement to calculate a corrected concentration of the analyte in the sample.2. The electrochemical system of claim 1 , wherein said parameter comprises a measured capacitance of the electrochemical cell.3. The electrochemical system of claim 1 , wherein said physical property is related to at least one of an age of the electrochemical cell and a storage condition of the electrochemical cell.4. The electrochemical system of claim 3 , wherein said storage condition comprises a storage temperature and a storage time.5. The electrochemical system of claim 1 , wherein the sample comprises blood.6. The electrochemical system of claim 5 , wherein the blood comprises whole blood.7. An electrochemical system ...

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Номер записи: 50
14-05-2015 дата публикации

Measuring Apparatus and Measuring Method

Номер: US20150129434A1
Автор: Fukuda Kazuo, Okami Akiko, Sato Yoshiharu
Принадлежит: ARKRAY, INC.

An apparatus and a method that can detect a defective analytical device due to the scattering of a reagent are provided. In particular, a blood glucose level meter (measuring apparatus) is configured to measure a target component of a biological sample using a reagent. The apparatus includes a second measuring unit (measuring unit) configured to measure an electrical response to a detection signal applied to a pair of hematocrit electrodes (test electrode pair), and a control unit configured to determine the presence or absence of the reagent on the pair of hematocrit electrodes based on the measured electrical response. 1. A method for measuring a target component of a biological sample with a reagent ,the method comprising the following steps of:applying a detection signal to at least one test electrode pair;measuring an electrical response to the detection signal in the test electrode pair; anddetermining a presence or absence of the reagent on the test electrode pair based on the measured electrical response.2. The measuring method according to claim 1 , wherein the presence or absence of the reagent on the test electrode pair is determined by comparing the measured electrical response with a known value in the step of determining the presence or absence of the reagent.3. The measuring method according to claim 1 , wherein a current value is measured as the electrical response to the detection signal in the step of measuring the electrical response.4. The measuring method according to claim 1 , comprising a step of measuring a first biological value by using the test electrode pair either before the step of applying the detection signal or after the step of measuring the electrical response.5. The measuring method according to claim 4 , wherein the test electrode pair claim 4 , which is not provided with the reagent claim 4 , is used in the step of measuring a first biological value.6. The measuring method according to claim 4 , comprising a step of measuring a ...

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Номер записи: 51
04-05-2017 дата публикации

ELECTRODE ARRANGEMENTS FOR TEST ELEMENT INTEGRITY

Номер: US20170122896A1
Автор: Buck, JERNIGAN Walter, JR. Harvey
Принадлежит: ROCHE DIABETES CARE INC.

A method is provided for verifying test element integrity includes providing a biosensor having an electrode-support substrate. A first electrode is provided on the substrate that includes a first body and a neck extending from the first body. A second electrode is provided on the substrate that includes a second body and an opposite pair of necks. Each of the necks extends from a respective end of the second body. A spacer is positioned on the substrate and has an edge defining a boundary of a capillary channel formed between a cover and the substrate. The method also includes applying a signal across the necks of the second electrode to verify continuity along the second electrode. The second body of the second electrode and the pair of connective necks surround the first electrode in the capillary channel forming a loop circuit around the first electrode. 1. A method of verifying integrity test element of a test element having an integrity electrode arrangement , the method comprising:providing a test element comprising (a) an electrode-support substrate, (b) a first electrode provided on the electrode-support substrate that includes a first body portion and a connective neck extending from the first body portion, (c) a second electrode provided on the electrode-support substrate that includes a second body portion and an opposite pair of connective necks, each one of the opposite pair of connective necks extending from a respective end of the second body portion, (d) a cover, and (e) a spacer coupled to the electrode-support substrate, the spacer including an edge defining a boundary of a capillary channel formed between the cover and the electrode-support substrate, wherein the second body portion of the second electrode and the opposite pair of connective necks surround the first electrode in the capillary channel forming a loop circuit around the first electrode; andapplying a signal across the pair of connective necks of the second electrode to verify ...

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Номер записи: 52
25-04-2019 дата публикации

Method And Apparatus For Implementing Threshold Based Correction Functions For Biosensors

Номер: US20190119716A1
Автор: Mecklenburg George A.
Принадлежит:

A biosensor system, method and apparatus are provided for implementing threshold based correction functions for biosensors. A primary measurement of an analyte value is obtained. A secondary measurement of a secondary effect is obtained and is compared with a threshold value. A correction function is identified responsive to the compared values. The correction function is applied to the primary measurement of the analyte value to provide a corrected analyte value. The correction method uses correction curves that are provided to correct for an interference effect. The correction curves can be linear or non-linear. The correction method provides different correction functions above and below the threshold value. The correction functions may be dependent or independent of the primary measurement that is being corrected. The correction functions may be either linear or nonlinear. 1. A method for implementing threshold based correction functions for a biosensor comprising the steps of:applying a sample to the biosensor and obtaining a primary measurement of an analyte value;obtaining a secondary measurement of a secondary effect;comparing said secondary measurement of the secondary effect with a threshold value;responsive to said compared values, identifying a correction function; andapplying said identified correction function to said primary measurement to provide a corrected analyte value.2. A method for implementing threshold based correction functions for a biosensor as recited in wherein the step responsive to said compared values claim 1 , of identifying a correction function includes the steps of identifying said secondary measurement of the secondary effect less than or equal to said threshold value claim 1 , identifying a first coefficient A claim 1 , said first coefficient A to control magnitude of said correction function.5. A method for implementing threshold based correction functions for a biosensor as recited in wherein the step responsive to said ...

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Номер записи: 53
31-07-2014 дата публикации

METHOD FOR MEASURING CONCENTRATION OF ANALYTE IN BLOOD SAMPLE, AND BIOSENSOR SYSTEM

Номер: US20140209482A1
Автор: UCHIYAMA Motonori
Принадлежит: PANASONIC HEALTHCARE CO., LTD.

The method includes: acquiring data a related to a temperature of a blood sample on a sensor chip, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result; acquiring data b related to the concentration of an analyte in the blood sample, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b. 1. A method for measuring a concentration of an analyte in a blood sample using a sensor chip , the sensor chip including a capillary and a pair of electrodes , the method including:acquiring data a related to a temperature of the blood sample, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result;acquiring data b related to the concentration of the analyte, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; andmeasuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b.2. The method according to claim 1 , whereinthe first voltage is between 1.0V and 3.0V, and the second voltage is between 0.05V and 1.0V.3. The method according to claim 1 , further includes correcting the data b based on the data a.4. The method ...

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Номер записи: 54
21-05-2015 дата публикации

ANALYTE MEASUREMENT METHOD AND SYSTEM

Номер: US20150136615A1
Автор: Craggs Adam, Malecha Michael
Принадлежит:

Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration. 2. The method of claim 1 , in which first tuning parameter is from about 9.9 to about 10.2 and second tuning parameter is from about 10.8 to about 11.2.3. A method for determining a hematocrit-corrected test current measurable with a system having a test strip and a meter claim 1 , the method comprising:applying a first test voltage between a reference electrode and a second working electrode coated with a reagent layer and applying a second test voltage between a reference electrode and a first working electrode coated with a reagent layer;measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing glucose is applied to the test strip;measuring a fifth test current at the first working electrode; anddetermining the hematocrit-corrected test current by determining a ratio of the first test current to the second test current raised to a power term and multiplying the ratio by the fifth test current, where the power term is a function of a first tuning parameter and a second tuning parameter.4. The method of claim 3 , in which first tuning ...

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Номер записи: 55
02-05-2019 дата публикации

FLUID ANALYZER FOR MEASURING A TARGET ANALYTE AND METHOD OF CALIBRATING AN AMPEROMETRIC SENSOR

Номер: US20190128832A1
Автор: Chan Andy, Li Jay
Принадлежит: SIEMENS HEALTHCARE DIAGNOSTICS INC.

A control system for a fluid analyzer is described. The control system has a processor executing processor executable code to: control a potentiostat to apply a first voltage potential sufficient to induce a first electrochemical reaction of a target analyte or a reaction byproduct of the target analyte in a sample of the calibration reagent and receive a first reading from the potentiostat; control the potentiostat to apply a second voltage potential insufficient to induce a second electrochemical reaction of the target analyte or a reaction byproduct of the target analyte in the sample of the calibration reagent and receive a second reading from the potentiostat; calculate calibration parameters using the first reading, the second reading and a multi-point calibration algorithm; and measure a target analyte concentration within the fluid sample using the calibration parameters. 1. A fluid analyzer for analyzing a fluid sample , comprising:a potentiostat, when in electrical communication with two or more electrodes of an amperometric sensor, configured to measure signals generated by at least two of the two or more electrodes, and to control a voltage difference between at least two of the two or more electrodes;at least one calibration injection port adapted to receive a calibration reagent having a predetermined target analyte level of a target analyte;at least one automated valve communicating with the at least one calibration injection port and being openable and closable to pass one or more samples of the calibration reagent; and control the at least one automated valve to pass the calibration reagent through a fluid channel to the two or more electrodes;', 'control the potentiostat to apply a first voltage potential sufficient to induce a first electrochemical reaction of a target analyte or a reaction byproduct of the target analyte in a sample of the calibration reagent and receive a first reading from the potentiostat;', 'control the potentiostat to apply ...

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Номер записи: 56
07-08-2014 дата публикации

Underfill Recognition Biosensor

Номер: US20140216930A1
Автор: Maurer Eric, Perry Joseph E., Trippel Christine, Wu Huan-Ping
Принадлежит: Bayer HealthCare LLC

A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample. 1. A biosensor with an underfill recognition system , comprising:a sensor strip having a sample interface on a base, where the sample interface is in electrical communication with a working electrode and a counter electrode, the working and counter electrodes positioned in a reservoir formed by the base; anda measuring device having a processor connected to a sensor interface, where the sensor interface has a signal generator, and where the sensor interface has electrical communication with the sample interface; andwhere the processor is capable of directing the signal generator to apply a regular polling sequence to a sample contacting the working electrode and the counter electrode, the regular polling sequence substantially eliminating irreversible alteration of the concentration of at least one analyte in the sample during the application of the regular polling sequence,where the processor is capable of detecting the presence of the sample,where the processor is capable of directing the signal generator to apply an extended polling sequence to the sample, the extended polling sequence having at least one different extended input pulse, and the extended polling sequence substantially eliminating irreversible alteration of the concentration of the at least one analyte in the sample during the application of the extended polling sequence,where the processor is capable of detecting whether a ...

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Номер записи: 57
07-08-2014 дата публикации

HEMATOCRIT CORRECTED GLUCOSE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP USING TIME DIFFERENTIAL OF THE SIGNALS

Номер: US20140216948A1
Автор: Farmahan Mandip, McColl David, Smith Antony
Принадлежит: LifeScan Scotland Limited

Various embodiments that allow for determination of hematocrit by a time differential between the input and output signals such that a glucose measurement for a blood sample can be corrected by the measured hematocrit of the blood sample. 1. A method to determine a glucose concentration in a blood sample , the method comprising:depositing a blood sample in a test chamber of a test strip having at least first and second electrodes in contact with a reagent and third and fourth electrodes not in contact with the reagent;driving a non-oscillating signal to the at least first and second electrodes to cause a reaction with the glucose in the blood sample and the reagent;measuring a current output of the reaction to establish a preliminary glucose concentration;applying a first oscillating input signal at a first frequency to third and fourth electrodes;detecting a first oscillating output signal from the third and fourth electrodes;measuring a first time differential between the first input and output oscillating signals;applying a second oscillating input signal at a second frequency to the third and fourth electrodes;detecting a second oscillating output signal from the third and fourth electrodes;measuring a second time differential between the first input and output oscillating signals;estimating a hematocrit of the blood sample based on the first and second time differentials; andderiving a final glucose concentration based on the preliminary glucose concentration and the hematocrit from the estimating step.2. The method of claim 1 , in which the first frequency comprises about 25 claim 1 ,000 Hertz and the second frequency comprises about 250 claim 1 ,000 Hertz.4. The method of claim 3 , in which the measuring of a current output for the preliminary glucose concentration is performed prior to the estimating of the hematocrit. This application claims the benefits of priority under 35 USC §119, 120, 365 and 371 of prior filed U.S. Provisional Patent Application Ser. ...

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Номер записи: 58
18-05-2017 дата публикации

Analyte Test Sensor And Method Of Manufacturing The Same

Номер: US20170138887A1
Автор: Ghesquiere Alexander G., Tonks Simon
Принадлежит:

An analyte test sensor for use in measuring the concentration of a particular analyte in a test sample includes a non-conductive substrate, a reference electrode deposited on the substrate, a working electrode deposited on the substrate and a compensation electrode deposited on the substrate. The compensation electrode is provided with a resistive ladder and is designed to correct for test result inaccuracies which are the result of variances in the manufacturing of the test sensor. Specifically, in one embodiment, the compensation electrode corrects for test result inaccuracies in an analog manner by shunting a portion of the working current away from working electrode. In another embodiment, the compensation electrode corrects for test result inaccuracies in a digital manner by providing a calibration code which is proportional its resistance value. A batch of analyte test sensors are preferably manufactured in the following manner. An initial batch of the test sensors is constructed. Then, a limited sampling of the sensors is tested for accuracy using a control sample. Based on the test results, the resistance value of the compensation electrode for each remaining sensor in the batch is adjusted accordingly. 118-. (canceled)19. A method of making a plurality of calibration-adjusted sensors , the method comprising:applying a known voltage to an electrode pair of the first sensor from a first batch of sensors to produce a working current through the electrode pair of the first sensor;measuring the working current of the first sensor in the presence of a control sample;comparing the measured working current to a target working current;modifying the resistance of an electrode pair of a second sensor from the first batch of sensors if the measured working current is not the same as the target working current;measuring a working current of the second sensor in the presence of a control sample to confirm that when the known voltage is applied to the electrode pair of ...

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Номер записи: 59
26-05-2016 дата публикации

SYSTEMS AND METHODS FOR ELECTROCHEMICAL HEMATOCRIT DETERMINATION BY ALTERNATE CURRENT IMPEDANCE PHASE ANGLE DETERMINATIONS

Номер: US20160146750A1
Автор: Hughes Gary L., Jesswein Ryan D.
Принадлежит:

A system for determining a level of hematocrit includes a test strip configured to receive a sample; a meter configured to receive the test strip; and further including circuitry and a microprocessor, the circuitry and microprocessor configured to apply electrical energy to the test strip and the sample and determine an electrical property of the sample, either the impedance phase angle or the impedance magnitude of the test strip and the sample and, based on the electrical property, calculate the level of hematocrit in the sample. 1. A system for determining a level of hematocrit , comprising:a test strip configured to receive a sample;a meter configured to receive the test strip; andfurther including circuitry and a microprocessor, the circuitry and microprocessor configured to apply electrical energy to the test strip and the sample and determine an impedance phase angle of the test strip and the sample and, based on the impedance phase angle, calculate the level of hematocrit in the sample.2. The system of claim 1 , wherein the circuitry and microprocessor are further configured to determine an impedance magnitude of the test strip and the sample.3. The system of claim 2 , wherein the level of hematocrit is based on both the impedance phase angle and the impedance magnitude.4. The system of claim 3 , wherein the circuitry and microprocessor are further configured to determine a glucose level of the sample.5. The system of claim 4 , wherein the level of hematocrit determined is based on the interrelationship between the impedance magnitude and phase angle claim 4 , wherein the glucose level and the level of hematocrit have disparate but proportional impacts on the impedance magnitude and the impedance phase angle claim 4 , such that the level of each of the glucose level and the level of hematocrit is determinable.6. The system of claim 5 , wherein the test strip includes a first sample window claim 5 , the first sample window including a first electrode and a ...

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Номер записи: 60
09-06-2016 дата публикации

Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium

Номер: US20160161439A1
Автор: Sekimoto Shinjiro
Принадлежит: ARKRAY, INC.

There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied. 112.-. (canceled)13. A sensor testing method comprising:applying to a reagent layer of a sensor section at least one of a first voltage across a first electrode and a second electrode to generate a response current by reaction of a reagent present in the reagent layer with a target substance in a sample liquid and a second voltage that results in no response current or substantially no response current, where the sensor section comprises the reagent layer, an electrode section comprising the first electrode, the second electrode and an external layer membrane for making contact with the reagent layer;measuring the response current flowing between the first electrode and the second electrode; andcomputing a time required for an amount of change in the response current per specific amount of change in time resulting from the application of the first voltage to reach a value in a predetermined first specific range prior to when the response current reaches a steady state for determining whether there is a defect present in the external layer membrane, orcomputing a time required for an amount of change in the response current per specific amount of change in time resulting from the application of the second voltage to reach a value in a predetermined second specific range prior to when the response current reaches a steady state for determining whether ...

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Номер записи: 61
09-06-2016 дата публикации

Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium

Номер: US20160161440A1
Автор: Sekimoto Shinjiro
Принадлежит: ARKRAY, INC.

There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied. 113.-. (canceled)14. A non-transitory computer-readable storage medium configured to store a program for causing a computer to execute a sensor testing method , the sensor testing method comprising:applying to a reagent layer of sensor section via a voltage application unit, at least one of a first voltage across a first electrode and a second electrode to generate a response current by reaction of a reagent present in the reagent layer with a target substance in a sample liquid and a second voltage that results in no response current or substantially no response current, where the sensor section comprises the reagent layer, an electrode section comprising the first electrode, the second electrode and an external layer membrane for making contact with the reagent layer;measuring via a current measurement unit, the response current flowing between the first electrode and the second electrode; andcomputing a time required for an amount of change in the response current as measured by the current measurement unit per specific amount of change in time resulting from the application of the first voltage to reach a value in a predetermined first specific determination unit whether there is a defect present in the external layer membrane, orcomputing a time required for an amount of change in the response current as measured by the current measurement unit ...

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Номер записи: 62
07-06-2018 дата публикации

ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP BASED ON SENSED PHYSICAL CHARACTERISTIC(S) OF THE SAMPLE CONTAINING THE ANALYTE

Номер: US20180156750A1
Автор: Malecha Michael, McColl David, Smith Antony
Принадлежит:

Various embodiments for methods and systems that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample containing the analyte and deriving one of a batch slope, sampling time, or combinations thereof to attain accurate glucose concentration. 1. A method of determining an analyte concentration from a fluid sample , the method comprising:depositing a fluid sample on a biosensor;applying signals to the sample to transform the analyte into a different material;measuring or estimating a physical characteristic of the sample;evaluating signal output from the sample;deriving a parameter of the biosensor from the measured or estimated physical characteristic; anddetermining an analyte concentration based on the derived parameter of the biosensor and the signal output of the sample.2. The method of claim 1 , in which the measuring comprises applying a first signal to the sample to measure a physical characteristic of the sample.3. The method of claim 2 , in which the evaluating comprises driving a second signal to the sample.4. The method of claim 3 , in which the applying of the first signal and the driving of the second signal is in sequential order.5. The method of claim 3 , in which the applying of the first signal overlaps with the driving of the second signal.6. The method of claim 5 , in which the applying of the first signal comprises directing an alternating signal to the sample so that a physical characteristic of the sample is determined from an output of the alternating signal.7. The method of claim 5 , in which the applying of the first signal comprises directing an optical signal to the sample so that a physical characteristic of the sample is determined from an output of the optical signal.8. The method of claim 7 , in which the physical characteristic comprises at least one of viscosity claim 7 , hematocrit claim 7 , temperature claim 7 , and density of the sample claim 7 , or ...

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Номер записи: 63
07-06-2018 дата публикации

Self correction for spatial orientation and motion of portable clinical analyzers

Номер: US20180157785A1
Автор: Gary Vandersleen, Graham Davis, Narendra Soman, Paul Wasserman, PIERRE Emeric
Принадлежит: ABBOTT POINT OF CARE INC

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

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Номер записи: 64
16-06-2016 дата публикации

Analyte Determination Method and Analyte Meter

Номер: US20160169828A1
Автор: Harding Ian, Iyengar Sridhar, Williams Richard
Принадлежит: AGAMATRIX, INC.

The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip. 1. A method for determining an analyte in a sample comprising the steps of:(a) placing the sample in an electrochemical test cell comprising a working and a counter electrode and a mediator that serves as a charge carrier in the electrochemical determination of the analyte,(b) electrochemically determining an uncorrected result for the determination of analyte in the sample;(c) determining an additive correction term for the amount of oxygen in the sample, and(d) modifying the uncorrected result of step (b) by adding the additive correction term of step (c) to provide a corrected determination of analyte in the sample,wherein the additive correction term for the amount of oxygen in the sample is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample.2. The method of claim 1 , wherein the sample is a blood sample.34-. (canceled)5. The method of claim 1 , wherein the measurement that reflects the oxygen carrying capacity of the sample is determined applying a potential for a period of time sufficient to establish a chemical potential gradient between the electrodes claim 1 , switching off the applied potential at a time t claim 1 , and obtaining a value indicative of the rate of decay of the chemical potential gradient in the absence of applied potential.6. The method of claim 5 , wherein the value indicative of the rate of decay is a time t claim 5 , which is determined by determining the time claim 5 , t ...

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Номер записи: 65
11-09-2014 дата публикации

METHODS AND SYSTEMS TO DETERMINE FILL DIRECTION AND FILL ERROR IN ANALYTE MEASUREMENTS

Номер: US20140251833A1
Автор: Smith Antony, WHITEHEAD Neil, WHYTE Lynsey
Принадлежит: LifeScan Scotland Limited

Various embodiments for methods and systems that allow for detecting of a direction in which a sample is flowing towards a plurality of electrodes and detecting a fill error of an electrochemical test strip.

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Номер записи: 66
25-06-2015 дата публикации

Analyte Sensors with Ethylene Oxide Immunity

Номер: US20150177177A1
Автор: Liu Zenghe
Принадлежит: GOOGLE INC.

Analyte sensors capable of undergoing sterilization with ethylene oxide are provided. The analyte sensors can include one or more polymer membranes having a nucleophilic group. 2. The analyte sensor of claim 1 , wherein the analyte sensing component is glucose oxidase.3. The analyte sensor of claim 1 , wherein the polymer membrane is in contact with one or more electrodes.4. The analyte sensor of claim 1 , wherein the nucleophilic group comprises a heteroatom.5. The analyte sensor of claim 1 , wherein the nucleophilic group is an alcohol.6. The analyte sensor of claim 1 , wherein the nucleophilic group is a pyridinyl group.7. The analyte sensor of claim 1 , wherein the nucleophilic group is negatively charged.8. The analyte sensor of claim 7 , wherein the nucleophilic group is a carboxylate.9. The analyte sensor of claim 7 , wherein the nucleophilic group is a sulfonate.10. The analyte sensor of claim 1 , wherein the polymer membrane comprises vinyl pyridine-derived units.11. The analyte sensor of claim 1 , wherein the polymer membrane comprises (meth)acrylate-derived units having a nucleophilic group.14. The analyte sensor of claim 13 , wherein the (meth)acrylate-derived units are derived from 2-hydroxyethylmethacrylate. Unless otherwise indicated herein, the materials described in this section are not prior art to the claims in this application and are not admitted to be prior art by inclusion in this section.The continuous or semi-continuous monitoring of physiological parameters has applications in many areas of modern medicine. The use of an electrochemical-based analyte sensor that employs an enzyme in conjunction with integrated electronic components can allow for the quantification of an analyte in a liquid sample. Medical devices are sterilized to prevent patients from exposure to infectious disease and other harmful organisms during use of the device. Typical sterilization techniques cannot be used with some analyte sensors because they will damage either ...

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Номер записи: 67
25-06-2015 дата публикации

Matrix Stability Compositions, Test Elements, Test Systems and Methods of Use Thereof

Номер: US20150177178A1
Автор: Duvall Stacy H., Kachel Sibylle, Lica Georgeta C., Schabel Wilhelm, Scharfer Philip
Принадлежит: ROCHE DIABETES CARE, INC.

Reagent matrices and methods are disclosed for improving the stability of test elements with respect to degradation by humidity in the air. The reagent matrices and methods are based upon using an effective amount of a deliquescent material to decrease the sorption of water from the air by other components of a reagent matrix. When the test element is a glucose-specific test strip, and the reagent matrix can include a glucose dehydrogenase enzyme and/or a flavin adenine dinucleotide cofactor, a nitrosoaniline mediator, and a film former, where the deliquescent material may include a salt such as sodium chloride in an amount effective to absorb water from the atmosphere at a rate that is faster than the rate at which the other components of the reagent matrix absorb water from the atmosphere. 1. A test element for determining a presence or a concentration of an analyte in a sample fluid , comprising:at least one working electrode and at least one counter electrode disposed upon a substrate; anda dry-film reagent matrix extending between the at least one working electrode and the at least one counter electrode and configured for an electrode reaction, wherein the dry-film reagent matrix comprises a deliquescent material and one or more active ingredients effective for facilitating a desired electrochemical reaction, wherein the deliquescent material is present in an amount effective to preemptively absorb water from the atmosphere when the relative humidity exceeds a predetermined level, and wherein the deliquescent material has a deliquescence point between about 50% relative humidity and about 80% relative humidity.2. The test element of claim 1 , wherein the deliquescent material has a deliquescence point at about 75% relative humidity.3. The test element of claim 1 , wherein the deliquescent material comprises one or more members selected from the group consisting of sodium chloride claim 1 , calcium chloride claim 1 , magnesium chloride claim 1 , magnesium ...

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Номер записи: 68
21-06-2018 дата публикации

Verifying Operation of a Meter

Номер: US20180172618A1
Автор: Baskeyfield Damian, Blythe Stephen
Принадлежит:

A method of verifying operation of a meter for reading electrochemical test devices, includes obtaining a reference output signal indicative of a response generated at an electrochemical test device when the electrochemical test device reacts with a reference test fluid; applying with the meter an algorithm to the reference output signal so as to obtain a reference test result, wherein the algorithm is for use in estimating an unknown concentration of an analyte in a sample of the reference test fluid; and determining whether the reference test result is valid so as to verify operation of the meter. 1. A method of verifying operation of a meter for reading electrochemical test devices , comprising:obtaining a reference output signal indicative of a response generated at an electrochemical test device when the electrochemical test device reacts with a reference test fluid;applying with the meter an algorithm to the reference output signal so as to obtain a reference test result, wherein the algorithm is for use in estimating an unknown concentration of an analyte in a sample of the reference test fluid; anddetermining whether the reference test result is valid so as to verify operation of the meter.2. The method of claim 1 , further comprising storing the reference output signal in a memory of the meter.3. The method of claim 1 , further comprising identifying an anomaly in the reference output signal in response to determining the reference test result is not valid.4. The method of claim 1 , further comprising identifying an error in the algorithm in response to determining the reference test result is not valid.5. The method of claim 1 , further comprising determining a corruption of a memory of the meter claim 1 , the memory storing the reference output signal and/or the algorithm.6. The method of claim 1 , wherein the sample of the reference test fluid is: blood claim 1 , plasma claim 1 , urine claim 1 , saliva claim 1 , lacrimal fluid claim 1 , sweat claim 1 , ...

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Номер записи: 69
22-06-2017 дата публикации

MEASURING DEVICE, MEASURING METHOD, AND SUPPLY DEVICE

Номер: US20170176373A1
Автор: KATASE Makoto
Принадлежит:

A measuring device includes a detecting unit including a conductive layer (a current measuring unit) configured to measure a value of an electric current that fluctuates according to the concentration of a measurement target substance, a temperature sensor (a temperature measuring unit) configured to measure an environmental temperature of an environment in which the conductive layer is placed, a storing unit configured to store, as a plurality of combinations, analytical curves of current fluctuation width due to a shift (Δt) of the environmental temperature from a set temperature and the concentration of the measurement target substance, and a computing unit configured to derive the concentration of the measurement target substance from the shift (Δt) of the environmental temperature from the set temperature, the current value, and the analytical curves. 1. A measuring device comprising:a current measuring unit configured to measure a value of an electric current that fluctuates according to concentration of a measurement target substance;a temperature measuring unit configured to measure an environmental temperature of an environment in which the current measuring unit is placed;a storing unit configured to store, as a plurality of combinations, analytical curves of current fluctuation width due to a shift (Δt) of the environmental temperature from a set temperature and the concentration of the measurement target substance; anda computing unit configured to derive the concentration of the measurement target substance from the shift (Δt) of the environmental temperature from the set temperature, the current value, and the analytical curves.2. The measuring device according to claim 1 , further comprising a temperature adjusting unit configured to adjust the environmental temperature.3. The measuring device according to claim 1 , wherein the plurality of combinations of the analytical curves are acquired according to a plurality of conditions for gradually ...

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Номер записи: 70
30-06-2016 дата публикации

METHODS AND APPARATUS FOR DETERMINING ANALYTE IN A SAMPLE USING A SENSOR HAVING ELECTRODES WHICH ARE PROVIDED WITH AN ENZYME AND A MEDIATOR

Номер: US20160186229A1
Автор: Hall Geoffrey Frank
Принадлежит:

The invention relates to a method of and apparatus for determining concentration of an analyte, such as glucose, in a fluid sample, such as body fluid or control solution, using a mediated redox reaction. In particular, the method relates to mitigation of the effects of haematocrit on the response of sensor device used in such a method or apparatus. The invention describes a method of determining concentration of an analyte in a fluid sample deposited on a sensor device having a working electrode and a counter electrode, in which the electrodes are provided with an enzyme and a mediator for carrying out a mediated redox reaction, the method comprising: applying a first oxidising potential between the working and counter electrodes during a first time period; applying a second reducing potential between the working and counter electrodes during a second time period; determining a reaction parameter, the reaction parameter being indicative of the concentration of reduced mediator at the counter electrode after commencement of the second time period; using the reaction parameter to determine the concentration of analyte. 1. A method of determining concentration of an analyte in a fluid sample deposited on a sensor device having a working electrode and a counter electrode provided on a substrate , in which the working and counter electrodes are both provided with an enzyme and a mediator for carrying out a mediated redox reaction , the method comprising:applying a first oxidising potential at a first voltage between the working and counter electrodes during a first time period;applying a second reducing potential at a second voltage between the working and counter electrodes during a second time period;wherein a duration of the first time period is greater than a duration of the second time period;determining a reaction parameter, the reaction parameter being indicative of the concentration of reduced mediator at the counter electrode after commencement of the second ...

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Номер записи: 71
04-06-2020 дата публикации

Residual Compensation Including Underfill Error

Номер: US20200173952A1
Автор: Harrison Bern, Maurer Eric, Wu Huan-Ping
Принадлежит:

A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species ora redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and compensates a portion of the remaining error with a residual function. The amount of error compensation provided by the primary and residual functions may be adjusted with a weighing coefficient. The compensation method including a primary function and a residual function may be used to determine analyte concentrations having improved accuracy from output signals including components attributable to error. 125-. (canceled)26. A biosensor system , for determining an analyte concentration in a sample , comprising:a test sensor having a sample interface in electrical communication with a reservoir formed by the test sensor; and where the processor instructs the signal generator to apply an electrical input signal to the sensor interface,', 'where the processor determines an output signal responsive to the input signal and the concentration of the analyte in the sample from the sensor interface,', 'where the processor compensates at least 50% of the total error in the output signal with a primary function,', 'where the processor compensates at least 5% of the remaining error in the output signal with a first residual function,', 'where the processor determines a compensated output signal, and', 'where the processor determines an analyte concentration in a sample from the compensated output signal., 'a measurement device having a processor connected to a sensor interface through a signal generator, the sensor interface having electrical communication with the sample interface, and the processor having electrical communication with a storage medium,'}27. The system of claim 26 , where the measurement device is portable.28. The system of claim 26 ,where the processor supplies temperature and hematocrit values ...

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Номер записи: 72
05-07-2018 дата публикации

Portable Clinical Analysis System for Hematocrit Measurement

Номер: US20180184955A1
Автор: Davis Graham, Emeric Pierre, Glavina Paul, Soman Narendra, Vandersleen Gary, Wasserman Paul, Zhao Tian-Xian
Принадлежит: ABBOTT POINT OF CARE INC.

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A method of performing a hematocrit analysis , the method comprising:inserting a test device comprising a hematocrit sensor into a port of an analyzer;initiating, by the analyzer, a test cycle of the test device, the test cycle including performance of the hematocrit analysis, wherein the performance of the hematocrit analysis includes the test device generating an electric signal based on a hematocrit measurement of a biological sample;determining spatial orientation and/or motion of the analyzer during the test cycle of the test device;comparing the determined spatial orientation to a threshold operating spatial plane for the test device and/or comparing the determined motion to a threshold rate of motion for the test device;when the determined spatial orientation exceeds the threshold operating spatial plane, and/or the determined motion exceeds the threshold rate of motion, providing an alert prompting a user to take corrective action,wherein the corrective action is instructed in the alert to be taken during the test cycle without having to reinitiate the test cycle including the performance of the hematocrit analysis.2. The method of claim 1 , further comprising correcting a result of the hematocrit analysis claim 1 , when the determined spatial orientation exceeds the threshold operating spatial plane and/or the determined motion exceeds the threshold rate of motion.3. The method of claim 1 , further comprising suppressing the result of the hematocrit analysis claim 1 , when the determined spatial orientation exceeds the threshold operating spatial plane and/or the determined motion exceeds the ...

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Номер записи: 73
05-07-2018 дата публикации

Improved Biosensor System Analyte Measurement

Номер: US20180188199A1
Автор: Wu Huan-Ping
Принадлежит:

Methods and biosensor systems for compensating an analyte measurement are provided. The methods and systems determine a secondary output signal based on the measured primary output signal in order to better approximate the effects of an extraneous stimulus on the primary output signal under actual measurement conditions. The methods and systems according to the present disclosure may provide a more accurate analyte measurement, and may be particularly useful in detecting and compensating an analyte measurement during an off-condition. 1. A method of determining an analyte concentration in a biological fluid sample , the method comprising:measuring a measured primary output signal from the biological fluid sample, the measured primary output signal being primarily responsive to the analyte concentration in the biological fluid sample;generating a generated secondary output signal, the generated secondary output signal being responsive to an extraneous stimulus affecting the measured primary output signal;back-calculating a back-calculated secondary output signal based on the measured primary output signal;adjusting the generated secondary output signal using the back-calculated secondary output signal to derive an adjusted secondary output signal; andconverting the measured primary output signal to the analyte concentration value using a conversion function with the adjusted secondary output signal to compensate for the effect of the extraneous stimulus on the measured primary output signal.2. The method of claim 1 , wherein the generated secondary output signal is extracted from the measured primary output signal.3. The method of claim 1 , wherein the generated secondary output signal is measured separately from the measured primary output signal.4. The method of claim 1 , wherein the extraneous stimulus is one of temperature claim 1 , hematocrit (Hct) or total hemoglobin (THb).5. (canceled)6. (canceled)7. The method of claim 1 , wherein back-calculating a secondary ...

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Номер записи: 74
02-10-2014 дата публикации

Accurate Analyte Measurements for Electrochemical Test Strip Based on Multiple Discrete Measurements Defined by Sensed Physical Characteristic(s) of the Sample Containing the Analyte

Номер: US20140291167A1
Автор: Malecha Michael
Принадлежит: LifeScan Scotland Limited

Various embodiments that allow for a more accurate analyte concentration by determining at least one physical characteristic, particularly hematocrit, of the blood sample containing the analyte, particularly glucose, and deriving a specific sampling time based on a relationship between the physical characteristic and sampling time so that the analyte concentration can be determined with greater accuracy with the specific sampling time point. 1. A method of determining an analyte concentration from a physiological sample with a biosensor having at least two electrodes and a reagent disposed on at least one electrode of the electrodes , the method comprising:depositing a physiological sample on any one of the at least two electrodes to start an analyte test sequence;applying a first signal to the sample to derive a physical characteristic of the sample;driving a second signal to the sample for a first sampling time duration that overlaps with the test sequence to obtain a first transient signal output from the sample, the first transient signal correlated to both time and magnitude during the first sampling time duration;extracting a specific sampling time during the test sequence in the first sampling time duration based on the physical characteristic of the sample;obtaining from the first transient signal a second transient signal over a second sampling time duration;deriving respective magnitudes of the second transient signal at selected time intervals in the second sampling time duration; anddetermining an analyte concentration based on respective magnitudes of the second transient signal at the selected time intervals.2. The method of claim 1 , further comprisingdefining the second sampling time duration based on the specific sampling time such that the second sampling time duration overlaps the first sampling time duration; anddividing the second transient signal into discrete time intervals with respect to the second sampling time duration, andin which the ...

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Номер записи: 75
19-07-2018 дата публикации

METHOD FOR CORRECTING CREA SENSOR FOR CALCIUM INHIBITION

Номер: US20180202963A1
Автор: HANSEN Thomas Steen, NYGAARD Thomas Pedersen
Принадлежит: Radiometer Medical APS

A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the device comprising an enzyme layer, the method comprising: determining sensitivities of the device for each of one or more calibration solutions; determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution; wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; and calculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution. 1. A method of calibrating a device for measuring the concentration of creatine and/or creatinine in a sample including one or more enzyme modulators , the device comprising an enzyme layer , the method comprising:determining sensitivities of the device for each of one or more calibration solutions;determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution;wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; andcalculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution.2. The method of claim 1 , wherein claim 1 , prior to the determining a degree of modulation for the sample claim 1 , the method further comprises:aspirating an earlier sample in the device.3. The method of claim 2 , wherein the period of time from aspirating the earlier sample to ...

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Номер записи: 76
09-10-2014 дата публикации

PERSONAL BLOOD GLUCOSE METER AND ABNORMAL MEASUREMENT DETECTION METHOD USING SAME

Номер: US20140299487A1
Автор: Cha Geun Sig, KIM Tae Eun, Lee Myeong-Ho, Nam Hakhyum, Suh Min Woo
Принадлежит: I-SENS, INC.

A personal blood glucose meter and a method for sensing abnormal measurement using the same are disclosed. A personal blood glucose meter includes: a sensor strip for collecting and applying a blood sample, wherein the sensor strip includes a reagent; an electrode unit including a plurality of electrodes for receiving the blood sample from the sensor strip to generate electric current based on potential differences; an MCU for measuring currents value generated from the electrode unit to determine whether a glucose value of the blood sample is normal or abnormal; a potential supply unit for applying a predetermined potential to the electrode unit; and a display unit displaying resultant output from the MCU. 1. A personal blood glucose meter comprising:a sensor strip for collecting and applying blood sample, wherein the sensor strip includes a reagent;an electrode unit including a plurality of electrodes for receiving the blood sample from the sensor strip to generate electric current based on potential differences;an MCU for measuring currents value generated from the electrode unit to determine whether the blood glucose value of the blood sample is normal or abnormal;a potential supply unit for applying a predetermined potential to the electrode unit; anda display unit for displaying resultant output from the MCU.2. The personal blood glucose meter as set forth in claim 1 , wherein the electrode unit includes:a flow sensing electrode for receiving the blood sample to generate first potential;an auxiliary electrode having a ground function; anda working electrode for receiving the blood sample to generate second potential.3. The personal blood glucose meter as set forth in claim 1 , wherein the MCU changes the predetermined potential of the plurality of electrodes of the electrode unit to measure the current value of the working electrode at least twice claim 1 , and compares the current value with a predetermined current value to determine whether the blood glucose ...

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Номер записи: 77
28-07-2016 дата публикации

REFERENCE ELECTRODE ERROR TRAP DETERMINED FROM A SPECIFIED SAMPLING TIME AND A PRE-DETERMINED SAMPLING TIME

Номер: US20160216226A1
Автор: Mackintosh Stephen, Smith Antony
Принадлежит:

Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether a counter or reference electrode is causing an error by monitoring the working electrodes and flagging an error if the signal outputs of the working electrodes do not meet certain thresholds. 1. An analyte measurement system with electrode error determination , the system comprising: a substrate;', physical characteristic sensing electrodes;', 'a first working electrode and a second working electrode; and', 'a reference electrode; and, 'a plurality of electrodes connected to respective electrode connectors with a reagent disposed proximate the plurality of the electrodes, the plurality of electrodes comprising], 'a test strip including a housing;', 'a test strip port connector configured to connect to the respective electrode connectors of the test strip; and', (a) apply a first signal to the physical characteristic sensing electrodes of the plurality of electrodes to determine a physical characteristic of a fluid sample;', '(b) apply a second signal between the first working electrode and the reference electrode, and between the second working electrode and the reference electrode to determine an analyte concentration of the fluid sample;', '(c) measure a signal output proximate a specified sampling time point from each of the first and second working electrodes;', '(d) measure another signal output proximate a predetermined sampling time point from each of the first and second working electrodes;', '(e) calculate a first differential between a signal output of the first working electrode measured at the specified sampling time point and a signal output of the first working electrode measured at the predetermined sampling time point;', '(f) calculate a second differential between a signal output of the second working electrode measured at the specified sampling time point and ...

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Номер записи: 78
26-07-2018 дата публикации

Normalized Calibration Of Analyte Concentration Determinations

Номер: US20180209932A1
Автор: Wu Huan-Ping
Принадлежит:

Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations. 177-. (canceled)78. A method for calibrating a measurement device of a biosensor system , the method comprising: a primary stimulus in the form of a reference sample analyte concentration from a reference sample, and', 'an extraneous stimulus resulting from one or more of a physical characteristic, an environmental aspect, or a manufacturing variation error incorporated into the analyte responsive output signals;, 'measuring at least two analyte responsive output signals, the analyte responsive output signals being affected by'}determining, via a measurement device, a reference correlation by relating the primary stimulus to the two analyte responsive output signals;measuring, from the reference sample, an extraneous stimulus responsive output signal of the extraneous stimulus and quantifying the extraneous stimulus responsive output signal to provide at least two quantified extraneous stimulus values;determining a normalizing relationship from the analyte responsive output signals and the two quantified extraneous stimulus values, the normalizing relationship being determined at a single selected sample analyte ...

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Номер записи: 79
04-07-2019 дата публикации

METHODS OF ELECTROCHEMICALLY MEASURING AN ANALYTE WITH A TEST SEQUENCE HAVING A PULSED DC BLOCK AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

Номер: US20190204258A1
Автор: Beaty Terry A., Carpenter Scott E., Pan Zheng Zheng, Surridge Nigel A.
Принадлежит: ROCHE DIABETES CARE, INC.

Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature or both before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one AC block and at least one pulsed DC block, where pulsed DC block includes at least one recovery potential, and where a closed circuit condition of the electrode system is maintained during the DC block. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods. 1. A method for electrochemical measurement of an analyte in a fluid sample comprising:applying an electrical test sequence to an electrochemical biosensor, the electrochemical biosensor comprising:an electrode system;a reagent in electrical communication with the electrode system;a receptacle configured to place the fluid sample provided to the electrochemical biosensor in fluidic contact with the reagent; and applying a preconditioning signal to the electrode system;', 'applying at least two direct current (DC) excitation signals to the electrode system after the applying of the preconditioning signal; and', 'applying at least one recovery potential to the electrode system by maintaining a closed circuit condition of the electrode system, each recovery potential in the at least one recovery potential being generated between two DC excitation signals in the at least two DC excitation signals;, 'the electrical test sequence further comprisinggenerating a current measurement from the electrode system during at least one DC excitation signal in the at least two DC excitation signals of the electrical test sequence; anddetermining a concentration of an analyte in the fluid sample based at least in part on the current measurement.2. The method of claim 1 , wherein the preconditioning signal is another DC excitation signal.3. The ...

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Номер записи: 80
04-07-2019 дата публикации

METHOD FOR MEASURING AN ANALYTE IN A BLOOD SAMPLE AND ANALYTE MEASURING DEVICE

Номер: US20190204259A1
Автор: CHANG Pei-Chen, CHEN Po-Han, LIN MENG-YI
Принадлежит:

A method includes steps of: applying a first voltage signal on a blood sample so as to obtain a preliminary value regarding an analyte in the blood sample; applying on the blood sample, a second voltage signal that includes cycles of a pulse and that has a voltage value alternating between high and low levels; measuring a physical quantity resulting from application of the second voltage signal on the blood sample at a time point in one of the cycles of the pulse of the second voltage signal so as to generate a calibration value; and calibrating the preliminary value based on the calibration value so as to obtain a calibrated value of the analyte in the blood sample which serves as a result of measurement of the analyte. 1. A method for measuring an analyte in a blood sample , to be implemented by an analyte measuring device , and comprising:applying, by the analyte measuring device, a first voltage signal on the blood sample so as to obtain a preliminary value regarding the analyte in the blood sample based on a measured physical quantity resulting from application of the first voltage signal;applying, by the analyte measuring device on the blood sample, a second voltage signal that includes N number of cycles of a pulse and that has a voltage value alternating between high and low levels, where N is an integer not smaller than two;measuring, by the analyte measuring device, a physical quantity resulting from application of the second voltage signal on the blood sample at a time point in one of the cycles of the pulse of the second voltage signal so as to generate a calibration value based on the physical quantity measured at the time point; andcalibrating, by the analyte measuring device based on the calibration value, the preliminary value of the analyte in the blood sample so as to obtain a calibrated value of the analyte in the blood sample which serves as a result of measurement of the analyte.2. The method as claimed in claim 1 , wherein the measuring the ...

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Номер записи: 81
23-10-2014 дата публикации

SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE AND CORRECTING FOR INTERFERENTS

Номер: US20140311924A1
Автор: Matzinger David, Teodorczyk Maria
Принадлежит: Cilag GmbH International

Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip. 3. The method of claim 2 , in which the step of switching comprises changing the polarity of the second voltage with respect to the first voltage.6. The method of claim 2 , in which the measuring of the first current output comprises measuring a current output of the at least two electrodes at about 1.1 seconds after initiation of test sequence.7. The method of claim 2 , in which the measuring of the second current output comprises measuring a current output of the at least two electrodes at about 4.1 seconds after initiation of test sequence.8. The method of claim 2 , in which the estimating of the steady state current output comprises measuring a current output of the at least two electrodes at about 5 seconds after initiation of test sequence.9. The method of claim 1 , in which the coefficients A and B comprise approximately 1.004 and approximately 0.0077 claim 1 , respectively.10. The method claim 2 , in which the coefficients A claim 2 , B claim 2 , C claim 2 , D claim 2 , and E comprise approximately 1.004 claim 2 , approximately 0.0077 claim 2 , approximately 0.889 claim 2 , approximately 0.0220 and approximately −0.00036 claim 2 , respectively.11. The method of claim 4 , in which the coefficients A and B comprise approximately 1.004 and approximately 0.0077 claim 4 , respectively.12. The method of claim 4 , ...

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Номер записи: 82
12-08-2021 дата публикации

METHOD FOR MEASURING COMPONENTS OF BIOLOGICAL SAMPLE

Номер: US20210247346A1
Автор: HIRONAKA Shouko, Mizuoka Daiki, Sasaki Suguru, YOSHIOKA Eriko
Принадлежит:

Provided is a method for measuring a component of a biological sample with a biosensor provided with: a capillary for introducing the biological sample; an electrode part including a first electrode system that includes a first working electrode and a first counter electrode in the capillary; and a reagent part disposed so as to be in contact with the electrode part, the reagent part containing an enzyme and a mediator, and the method including a step of starting voltage application for a duration longer than 0 second and up to 0.7 second to the first electrode system within 0 second to 0.5 second after detection of the introduction of the biological sample to obtain a hematocrit value based on a current value obtained thereby. 126-. (canceled)27. A biosensor , comprising:a capillary for introducing a biological sample;a reagent part containing an enzyme and a mediator in the capillary;a first hematocrit measurement system for measuring a hematocrit value, the first hematocrit measurement system being disposed so as to be in contact with the reagent part in the capillary and comprising a first working electrode and a first counter electrode; anda second hematocrit measurement system for measuring a hematocrit value, the second hematocrit measurement system comprising a second working electrode at a place where the reagent part is not disposed and a second counter electrode disposed so as to be in contact with the reagent part.28. The biosensor according to claim 27 , further comprising:an electrode system for obtaining a current value that depends on glucose, the electrode system being disposed so as to be in contact with the reagent part in the capillary and comprising a third working electrode and a third counter electrode; andan electrode system for obtaining a current value that depends on glucose, the electrode system being disposed so as to be in contact with the reagent part in the capillary and comprising a fourth sixth working electrode and a fourth sixth ...

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Номер записи: 83
18-07-2019 дата публикации

DESCRIPTOR-BASED METHODS OF ELECTROCHEMICALLY MEASURING AN ANALYTE AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

Номер: US20190219534A1
Автор: Carpenter Scott E., Pan Zheng Zheng
Принадлежит: ROCHE DIABETES CARE, INC.

Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as hematocrit, salt concentration and/or temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the excitation and recovery pulses are used to build within- and across-pulse descriptors to correct/compensate for hematocrit, salt concentration and/or temperature effects on the analyte concentration. Methods of transforming current response data also are disclosed. Further disclosed are devices, apparatuses and systems incorporating the various measurement methods. 2. The method of further comprising the step of transforming the excitation current response information and the recovery current response information from a first x-y space claim 1 , where x=time and y=current to a second x-y space where x=ln(time) and y=ln(current).3. The method of claim 1 , wherein the determining the analyte concentration step uses descriptors encoding magnitude and shape characteristics of the transformed excitation current response information and the transformed recovery current response information.4. The method of claim 1 , wherein the determining the analyte concentration step is based upon an effective current determined based upon the transformed excitation current response information and the transformed recovery current response information.6. The method of claim 1 , wherein 95% of analyte concentrations fall within ±10 mg/dl of a reference at concentrations less than about 75 mg/dL claim 1 , and wherein 95% of analyte concentrations fall within ±10% of the reference at concentrations greater than ...

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Номер записи: 84
13-11-2014 дата публикации

Accurate Analyte Measurements for Electrochemical Test Strip Based on Sensed Physical Characteristic(s) of the Sample Containing the Analyte

Номер: US20140332408A1
Автор: Malecha Michael, McColl David, Smith Antony
Принадлежит: LifeScan Scotland Limited

Various embodiments for methods and systems that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample containing the analyte and deriving one of a batch slope, sampling time, or combinations thereof to attain accurate glucose concentration. 1. A method of determining an analyte concentration from a fluid sample with a biosensor having at least two electrodes and a reagent disposed on at least one of the electrodes , the method comprising:depositing a fluid sample on any one of the at least two electrodes to start an analyte test sequence;applying a first signal to the sample to measure or estimate a physical characteristic of the sample;deriving a batch slope for the biosensor based on the measured or estimated physical characteristic;driving a second signal to the sample;measuring an output signal from at least one of the at least two electrodes; andcalculating an analyte concentration based on the measured output signal and thederived batch slope from the measured or estimated physical characteristic of the sample.2. A method of demonstrating increased accuracy of a test strip , the method comprising:providing a batch of test strips;introducing a referential sample containing a referential concentration of an analyte to each test strip of the batch of test strips to initiate a test sequence;reacting the analyte with a reagent on each test strip to cause a physical transformation of the analyte proximate the two electrodes;determining a physical characteristic of the referential sample;deriving a defined batch slope for the batch of test strips based on the determined physical characteristics of the referential sample;sampling an electrical output of the referential sample at a predetermined time point during the test sequence;calculating an analyte concentration based on the defined batch slope and sampled electrical output to provide for a final analyte concentration value for each test ...

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Номер записи: 85
23-08-2018 дата публикации

OPERATION AND VERIFICATION OF A PORTABLE CLINICAL ANALYSIS SYSTEM

Номер: US20180238854A1
Автор: Davis Graham, Emeric Pierre, Fetters Christopher, Soman Narendra, Vandersleen Gary, Wasserman Paul
Принадлежит: ABBOTT POINT OF CARE INC.

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A portable clinical system for in vitro analysis , the system comprising:a test device configured to perform an in vitro analytical test; and a port configured to receive the test device and', determine spatial orientation and motion of the analyzer during a test cycle of the test device,', 'generate a test cycle profile for the test cycle, wherein the generated test cycle profile indicates the determined spatial orientation and motion of the analyzer during the test cycle,', 'compare the generated test cycle profile to a pre-established profile for the test device,', 'determine whether the generated test cycle profile deviates from the pre-established profile, and', 'at least one of (i) provide an alert prompting a user of the system to take corrective action and (ii) perform system maintenance, when the test cycle profile deviates from the pre-established profile., 'a computing device configured to], 'an analyzer comprising'}2. The system of claim 1 , wherein the computing device is further configured to determine whether the system maintenance fails and to communicate the failure of the system maintenance to an electronic auditable system.3. The system of claim 1 , wherein the computing device is further configured claim 1 , when the generated test cycle profile deviates from the pre-established profile claim 1 , to prevent reporting of a test result obtained from performance of the in vitro analytical test claim 1 , and to provide an alert prompting the user of the system that the system maintenance is required.4. The system of claim 3 , wherein the computing device is further configured to ...

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Номер записи: 86
23-07-2020 дата публикации

A DIAGNOSTIC SENSOR

Номер: US20200229742A1
Автор: "OCONNELL Ivan", "OFARRELL Brian", Cummins Timothy, DARBY Steven
Принадлежит:

A diagnostic sensor device has a semiconductor chip having a distal end physically configured to fit into a power and data socket conforming to a non-proprietary standard, and having exposed pads for engagement with corresponding conductors of such a socket. At its proximal end the chip has at least one sensor for contact with an analyte. The device may be manufactured in a single integrated process to provide a wafer which is diced to provide the individual devices. 1. A diagnostic sensor device comprising: a distal end physically configured to fit into a connector conforming to a non-proprietary data and power transfer standard, and said distal end having exposed pads for engagement with corresponding conductors of such a connector socket;', 'at least one sensor for contact with an analyte, and', 'a sensing circuit linked with the or each sensor and said pads, wherein the sensing circuit includes converters and digital calibration circuits, at least some of the converters and digital calibration circuits are located directly beneath the sensors, and the circuit comprises capacitive sensors., 'a monolithic semiconductor integrated circuit comprising2. The diagnostic sensor device as claimed in claim 1 , wherein the device comprises a layer of hydrophobic material which is etched to form an exposed sensing region for each sensor.3. The diagnostic sensor device as claimed in claim 1 , wherein the device comprises a layer of hydrophobic material which is etched to form an exposed sensing region for each sensor claim 1 , and wherein the hydrophobic material comprises polyimide.4. (canceled)5. (canceled)6. (canceled)7. The diagnostic sensor device as claimed in claim 1 , wherein the device distal end is configured to fit into a 12-pin USB connector socket or a 12-pin FFC socket.8. The diagnostic sensor device as claimed in claim 1 , wherein the sensor device is configured to mimic a flat flex cable in terms of dimensions.9. The diagnostic sensor device as claimed in ...

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Номер записи: 87
31-08-2017 дата публикации

EQUILIBRIUM POTENTIAL ESTIMATING METHOD, EQUILIBRIUM POTENTIAL ESTIMATING DEVICE, CONCENTRATION ESTIMATING DEVICE, PROGRAM, MEDIUM AND BLOOD SUGAR ESTIMATING DEVICE

Номер: US20170248545A1
Автор: AYABE Masaaki, UDAGAWA Ken
Принадлежит:

An oxidation-reduction substance equilibrium potential estimating method is provided, the method including: 1. An oxidation-reduction substance equilibrium potential estimating method , comprising:applying a voltage to an electrode contacting a sample containing an oxidation-reduction substance and sweeping the voltage;measuring a current flowing through the electrode;if an integrated value of the current becomes a value within a reference range, determining whether to sweep the voltage in an opposite direction to a sweep direction in the previous sweeping or to terminate sweeping of the voltage;if it is determined to terminate sweeping of the voltage, estimating an oxidation-reduction substance equilibrium potential at a value of the voltage; andif it is determined to sweep the voltage, sweeping the voltage in an opposite direction to a sweep direction in the previous sweeping.2. The oxidation-reduction substance equilibrium potential estimating method according to claim 1 , whereinif an integrated value of the current becomes a value within the reference range, the determining has judging whether or not a sweep width of the voltage, a change amount between the currents corresponding to the sweep width or a change amount between the integrated values corresponding to the sweep width is within a tolerated range,if it is judged that the value is within the tolerated range, the estimating has estimating the equilibrium potential at a voltage value within the tolerated range, andif it is judged that the value is outside the tolerated range, the sweeping the voltage in an opposite direction has sweeping the voltage in an opposite direction to a sweep direction in the previous sweeping.3. The oxidation-reduction substance equilibrium potential estimating method according to claim 1 , whereinthe determining has: determining to sweep the voltage in an opposite direction to a sweep direction in the previous sweeping if a number of times of the sweeping is less than N (N is ...

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Номер записи: 88
07-09-2017 дата публикации

METHOD FOR MEASURING CONCENTRATION OF ANALYTE IN BLOOD SAMPLE, AND BIOSENSOR SYSTEM

Номер: US20170254773A1
Автор: UCHIYAMA Motonori
Принадлежит:

The method includes: acquiring data a related to a temperature of a blood sample on a sensor chip, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result; acquiring data b related to the concentration of an analyte in the blood sample, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b. 1. A sensor chip comprising:a glucose measurement system configured to measure glucose of a biological sample;a temperature measurement system configured to measure temperature of the biological sample; anda capillary in which the biological sample is introduced, the capillary introducing the biological sample into the glucose measurement system and the temperature measurement system in order;wherein the glucose measurement system includes a first working electrode, a first counter electrode and a reagent portion;the temperature measurement system includes a second working electrode and a second counter electrode.2. The sensor chip according to claim 1 , whereinthe first working electrode, the first counter electrode, the second working electrode and the second counter electrode are formed independently.3. The sensor chip according to claim 1 , whereinthe temperature measurement system is disposed out of touch with the reagent portion.4. The sensor chip according to claim 1 , whereinthe reagent portion includes an oxidoreductase and a mediator.5. The sensor chip according to claim 1 , whereinan area of the second counter electrode is either the same or larger than an ...

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Номер записи: 89
15-08-2019 дата публикации

LIQUID SAMPLE MEASUREMENT DEVICE, LIQUID SAMPLE MEASUREMENT METHOD, AND BIOSENSOR

Номер: US20190250119A1
Автор: FUJIWARA Masaki, YAMAMOTO Tomohiro
Принадлежит:

It is intended to provide, for example, a liquid sample measurement device capable of measuring the amounts of components of a liquid with a high accuracy. A first voltage is applied to an electrode pair , which composes a biosensor , to obtain a first response value, a second voltage is applied to an electrode pair , which composes the biosensor , to obtain a second response value, and a current that is generated when a third voltage is applied to an electrode pair , which composes the biosensor , is detected to obtain a third response value. A liquid sample measurement device uses the first response value, the second response value, and the third response value to obtain the concentration of glucose and the amount of blood cells of blood as well as the value equivalent to the temperature of the biosensor 1. A liquid sample measurement device that measures the amounts of components using a biosensor in which a liquid is introduced and then components contained in said liquid are subjected to oxidation-reduction using an oxidoreductase ,wherein the liquid sample measurement device comprises:a first current value measure that detects, as a first current value, an oxidation-reduction current that is generated by the oxidation-reduction when a first voltage is applied to a first electrode pair, which composes the biosensor;a second current value measure that detects, as a second current value, a current that is generated when a second voltage is applied to a second electrode pair, which composes the biosensor;a third current value measure that detects, as a third current value, a current that is generated when a third voltage is applied to a third electrode pair, which composes the biosensor;a controller that controls a voltage value and a voltage application period of each of the first voltage, the second voltage, and the third voltage, that applies the second voltage and the third voltage to the second electrode pair and the third electrode pair, respectively, while ...

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Номер записи: 90
06-08-2020 дата публикации

ANALYTE MEASUREMENT DEVICE

Номер: US20200249193A1
Автор: Klemm Thomas
Принадлежит:

Analyte measurement devices and methods of measuring an analyte in a sample. At least one of the methods include: applying an electrical analysis signal to the sample during a measurement time interval (MT), wherein the electrical analysis signal, when transferred into a frequency space, comprises a superposition of two or more non-zero frequency components at least at a sampling time; measuring at least one electrical response signal from the sample; analyzing the electrical response signal; and determining the amount of the analyte in the sample based on the analyzing. 115.-. (canceled)16. A method of measuring an analyte in a sample , the method comprising:applying an electrical analysis signal to the sample during a measurement time interval, wherein the electrical analysis signal, when transferred into a frequency space, comprises a superposition of two or more non-zero frequency components at least at one or more sampling times;measuring at least one electrical response signal from the sample;analyzing the electrical response signal; anddetermining an amount of the analyte in the sample based on the analyzing.17. The method according to claim 16 , wherein the electrical analysis signal comprises a noise signal claim 16 , the noise signal comprising at least one of: a white noise frequency spectrum claim 16 , a pink noise frequency spectrum claim 16 , a red noise frequency spectrum claim 16 , a blue noise frequency spectrum claim 16 , a violet noise frequency spectrum claim 16 , or a grey noise frequency spectrum.18. The method according to claim 16 , wherein:the electrical response signal is filtered by a variable bandpass filter, the variable bandpass filter comprising a center frequency that is varied during the measurement time interval; andanalyzing the electrical response signal comprises analyzing at least a portion of the electrical response signal that is filtered by the variable bandpass filter.19. The method according to claim 17 , wherein:the one or ...

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Номер записи: 91
01-10-2015 дата публикации

Method for fast measurement of specimen concentration

Номер: US20150276650A1
Автор: Chien-Hung Lai, Fang-Yi Jiang, Po-Hao Lin, Shih-Jen Lu, Shu-Wei Yang, Ya-Sian Lin, Yi-Chen Chen, Yi-Lung Chen, Yu-Hsuan Tai
Принадлежит: BROADMASTER BIOTECH CORP

A method for fast measurement of a specimen concentration which needs a sensing strip with an electrode test region on which an enzymatic reagent with a specific ingredient is coated and has steps as follows: place a specimen on the electrode test region of the sensing strip; apply a high voltage on the electrode test region for a period to create electrochemical current therein by which at least a faradic current and at least a non-faradic current are generated in the electrode test region; apply a measuring voltage less than the high voltage or the same as the high voltage on the electrode test region to generate a total current including faradic and non faradic currents and the total current finally reaching a steady current, which is measured for calculating a specimen concentration.

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Номер записи: 92
01-10-2015 дата публикации

ELECTROCHEMICAL BIOSENSING METER, SYSTEM AND MEASURING METHOD FOR ANALYTE MEASUREMENT INCORPORATING FILLED SAMPLE DETECTION

Номер: US20150276670A1
Автор: Chen Chao-Wang, CHOU TAI-CHENG, Hou Hui-Sheng, Wu Chia-Chi
Принадлежит:

The present invention related to an electrochemical biosensing meter, a system and a measuring method for analyte measurement incorporating filled sample detection. The method comprises detecting a third electrical signal obtained from a second electrode pair on a test strip and detecting a second electrical signal obtained from a first electrode pair on the test strip. The second electrode pair is close to a sample entrance of a sample chamber and the first electrode pair is far away from the sample entrance of the sample chamber. The third electrical signal is used for detecting the state of the sample chamber when sufficiently filled. Compare the second electrical signal and the third electrical signal to determine the distribution state of the sample in the sample chamber. Therefore, it increases the credibility for the entire sample chamber sufficiently filled with the sample. 1. A method for filling sample detection , comprising: a sample chamber containing a first end and a second end, and the first end and the second end disposed in relative position, and the first end having a sample entrance; and', 'a conducting layer comprising a first electrode pair and a second electrode pair and one end of the first electrode pair and the second electrode pair respectively disposed in the sample chamber, wherein the end of the first electrode pair is far away from the first end of the sample chamber and the end of the second electrode pair is close to the first end of the sample chamber;', 'providing the sample at the sample entrance to let the sample fill into the sample chamber;, 'providing an electrochemical biosensor strip used for determining an analyte concentration in a sample, which comprising'}detecting a second electrical signal obtained from the first electrode pair;detecting a third electrical signal obtained from the second electrode pair, and the third electrical signal used for determining the filled state of the sample chamber;comparing the second ...

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Номер записи: 93
01-10-2015 дата публикации

ELECTRODE STRIP AND SENSOR STRIP AND MANUFACTURE METHOD THEREOF AND SYSTEM THEREOF

Номер: US20150276671A1
Автор: Chu Ching-Yuan, HUANG LAN-HSIANG, HUANG Ying-Che
Принадлежит:

The present disclosure relates to an electrode strip, a sensor strip, a system thereof and a manufacturing method thereof. The sensor strip includes a first reactive film, a second reactive film and a vent hole. The first reactive film includes a substrate, a first electrode layer and a first insulation layer. The first end of the first insulation layer is concaved to a first depth to form a first reactive area. The second reactive film includes a second electrode layer and a second insulation layer. The first end of the second insulation layer is concaved to a second depth to form a second reactive area. The vent hole penetrates the second insulation layer, the second electrode layer and the first insulation layer so as to connect the first reactive area and the second reactive area. 1. A method for manufacturing a sensor strip , comprising the steps of:providing a first reactive film and a second reactive film, wherein the first reactive film includes a first reactive area, and the second reactive film includes a second reactive area;disposing the first reactive film on the second reactive film; andforming a vent hole penetrating the first reactive film and connecting the first reactive area and the second reactive area.2. The method for manufacturing a sensor strip according to claim 1 , wherein the step of providing the first reactive film includes the following steps:providing a substrate;disposing a first electrode layer on the substrate;forming a first insulation layer on the first electrode layer wherein a first end of the first insulation layer is concaved to form the first reactive area within a first depth; andcoating or printing a first reaction layer in the first reactive area.3. The method for manufacturing a sensor strip according to claim 2 , wherein the step of forming the first insulation layer further includes a step of exposing an electrode of the first electrode layer adjacent to a second end of the first insulation layer and wherein the step of ...

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Номер записи: 94
21-09-2017 дата публикации

Methods of making a test sensor

Номер: US20170269020A1
Автор: Feldman Benjamin J., WANG Yi
Принадлежит:

A sensor, and methods of making, for determining the concentration of an analyte, such as glucose, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and may include an insertion monitoring trace to determine correct positioning of the sensor in a connector. The sensor is calibration-adjusted, eliminating the need for a user to enter a calibration code or for the meter to read a calibration code.

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Номер записи: 95
21-09-2017 дата публикации

Substance Measuring Method and Measuring Apparatus Using Electrochemical Biosensor

Номер: US20170269022A1
Автор: Katsuki Koji
Принадлежит: ARKRAY, INC.

Provided is a measuring method using a biosensor, the method including: introducing a sample containing a substance to be measured into an electrochemical measurement cell, wherein the electrochemical measurement cell comprises: an insulating base plate; and an electrode system applying a first voltage to the electrode system; applying a second voltage to the electrode system; obtaining a first signal; obtaining a second signal; and correcting the second signal by the first signal, to determine the concentration of the substance to be measured in the sample.

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Номер записи: 96
27-09-2018 дата публикации

Slope-Based Compensation Including Secondary Output Signals

Номер: US20180275089A1
Автор: Huang Dijia, Wu Huan-Ping
Принадлежит:

A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. 1. (canceled)268-. (canceled)69. A method for determining an analyte concentration in a biological sample from a test sensor including a sample interface having a working electrode and a counter electrode , an additional sensor and a measurement device including a processor and a signal generator connected to the processor , the method comprising:applying an electrical input signal from the signal generator to the biological sample through the working electrode and the counter electrode of the sample interface,generating from the input signal an analytic output signal in response to a redox reaction of an analyte from the biological sample;generating a secondary output signal from the biological sample from the additional sensor, the secondary output signal in response to the hematocrit content of the sample, the secondary output signal being generated independently from the redox reaction of the analyte from the biological sample;measuring the temperature of the biological sample; a) at least one term based on values extracted from the analytic output signal,', 'b) at least one term of the interaction based on the temperature measurement; and', 'c) at least one term including the hematocrit content determined from the secondary output signal; and, 'determining at least one index function responsive to multiple error parameters, the index function ...

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Номер записи: 97
05-10-2017 дата публикации

TEST STRIP AND METHOD OF OPERATION THEREOF

Номер: US20170284955A1
Автор: CHEN FAN-YU, LAI CHIEN-HUNG, LIN YA-SIAN
Принадлежит:

Test strip and method of operating thereof are provided. The test strip, from the top down, comprises a cover, an insulating layer, an electrode set, and a substrate. More particularly, the electrode set at least comprises a first electrode, a second electrode, and a third electrode. The insulating layer comprises a track, and the cover comprises an inlet, an indication line, and at least one vent. With the third electrode and the indication line in accordance with the present invention, a user may confirm the operation status of the test strip and the loading status of biological samples with ease to improve the accuracy of testing. 1. A test strip for biomaterials , comprising:a substrate, wherein the substrate is a layer of polyester;an electrode set disposed on the substrate, wherein the electrode set comprises a first electrode, a second electrode, and the third electrode;an insulating layer disposed on the electrode set, wherein the insulating layer comprises a track at one end of the insulating layer;a cover disposed on the insulating layer, wherein the cover comprises an inlet, an indication line, and at least one vent;wherein the first electrode contains a first reaction region exposed to the track;wherein the third electrode contains a third reaction region exposed to the track;wherein the second electrode contains a second reaction region;wherein the first reaction region is configured at the outer area of the track, the third reaction region is configured at the inner area of the track, and the second reaction region is configured between the first reaction region and the third reaction region;wherein the inlet is disposed at one end of the cover close to the track;wherein the indication line is configured at one end of the track away from the inlet; andwherein the at least one vent is configured with the indication line away from the inlet.2. The test strip as claimed in claim 1 , wherein the first electrode is a working electrode.3. The test strip as ...

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Номер записи: 98
27-08-2020 дата публикации

Biosensor Systems for Determining Analyte Concentration Based On Complex Index Functions

Номер: US20200271615A1
Автор: Jung Sung-Kwon, Wu Huan-Ping
Принадлежит:

A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. 125-. (canceled)26. A biosensor system , for determining an analyte concentration in a fluid sample , comprising:a test sensor having a sample interface adjacent to a reservoir holding the fluid sample, wherein the test sensor generates at least one output signal responsive to the concentration of the analyte in the fluid sample; and determine at least one output signal value from the output signal received from the sensor interface, wherein the at least one output signal value represents an unknown concentration of the analyte in the fluid sample,', 'determine at least one ΔS value from at least a complex index function stored in the storage medium, wherein the at least one ΔS value represents a slope deviation between a slope of a correlation between analyte concentration and the at least one output signal, and a hypothetical slope of a perfect correlation between analyte concentration and output signals, the correlation between analyte concentration and the at least one output signal determined from a previously determined reference correlation between previously determined reference output signal values and reference sample analyte concentration values, the reference sample analyte concentration values ...

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Номер записи: 99
13-10-2016 дата публикации

ANALYTE METER AND METHOD OF OPERATION

Номер: US20160299097A1
Автор: ELDER David, Forlani Christian, GUTHRIE Brian, LLOYD Timothy, Massari Rossano, McColl David, Smith Antony
Принадлежит:

An analyte meter having a test strip port is configured to transmit an electric signal through a received test strip with a sample. A pair of electrodes apply the electric signal and receive an electrical response from the test strip. A processing unit analyzes the electrical response and uses the response to determine an analyte level of the sample. 127.-. (canceled)28. A portable analyte test meter for use with an associated analytical test strip in the determination of a hematocrit concentration of a blood sample applied to the test strip through finger contact , said test meter comprising:a housing;a port for receiving the associated analytical test strip;a low pass filter circuit block disposed in the housing;a square wave generator circuit block disposed in the housing and connected to the low pass filter circuit block, the square wave generator configured to generate a square wave at a frequency in the range of about 70 kHz to about 80 kHz and to transmit the generated square wave signal to the associated analytical test strip in the port via the low pass filter circuit block; anda processing block configured to calculate a magnitude of a signal received from the associated analytical test strip, wherein the signal received from the associated analytical test strip originated from the generated square wave.29. The portable analyte test meter of claim 28 , wherein the port comprises electrodes for electrically connecting to the associated analytical test strip.30. The portable analyte test meter of claim 29 , wherein the magnitude of the signal received from the associated analytical test strip indicates the hematocrit concentration and wherein the processing block calculates the hematocrit concentration based on the magnitude of the signal.31. The portable analyte test meter of claim 28 , wherein the associated analytical test strip comprises a chamber having a sample therein.32. The portable analyte test meter of claim 28 , wherein the low pass filter block ...

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Номер записи: 100