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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 5960. Отображено 100.
01-03-2012 дата публикации

Acquisition and Analysis of Mixed Ion Populations in a Mass Spectrometer

Номер: US20120049056A1
Автор: Michael W. Senko, Scott T. Quarmby, Vladimir Zabrouskov
Принадлежит: Thermo Finnigan LLC

A method of obtaining and analyzing a mass spectrum of a sample comprising components is characterized by: setting values of a first energy level and a second energy level; chromatographically separating the components; ionizing a portion of the separated components to create precursor ions; introducing a first portion of the precursor ions into a collision or reaction cell and generating a first sub-population of ions corresponding to the first energy level; introducing a second portion of the precursor ions into the cell and generating a second sub-population of ions corresponding to the second energy level; transferring a mixture of the first and second sub-populations of ions into a mass analyzer; producing an analysis of the ions of the mixture; varying the value of at least one of the first and the second energy levels according to a pre-determined cyclical variation; repeating various above steps; and analyzing the time-variation of the analyses.

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Номер записи: 1
29-03-2012 дата публикации

Calibration function for time-of-flight mass spectrometers with extreme mass accuracy

Номер: US20120074303A1
Автор: Oliver Räther
Принадлежит: Bruker Daltonik GmbH

A calibration function for time-of-flight mass spectrometers that converts ion times of flight into mass to charge ratios, takes into account not only the time of flight of a specific ionic species, but also the ion signal intensity of that ionic species. Use of the conversion function reduces nonsystematic deviations of the calculated mass values from the true mass values previously experienced in time of flight mass spectrometers.

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Номер записи: 2
19-04-2012 дата публикации

Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer

Номер: US20120091330A1
Автор: Graeme C. McAlister, Joshua J. Coon
Принадлежит: Individual

Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. Following injection and selection of a particular ion type or population, that population can be fragmented using the pre-existing ion injection pathway or inlet of a mass spectrometer. This is achieved by transmitting the ions back along the ion injection pathway. As the ions pass into the higher pressure regions located in or near the atmospheric pressure inlet, the ions are fragmented and then trapped. Following fragmentation and trapping, the ions can either be re-injected into the primary ion selection device or sent on to a secondary mass analyzer.

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Номер записи: 3
03-05-2012 дата публикации

Multi-Channel Detection

Номер: US20120104245A1
Автор: Alexander Alekseevich Makarov
Принадлежит: Thermo Fisher Scientific Bremen GmbH

A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has traveled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.

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Номер записи: 4
24-05-2012 дата публикации

Magnetic Sector Mass Spectrometry Based Multi-Parametric Particle Analyzer

Номер: US20120126114A1
Автор: Dmitry R. Bandura, Scott D. Tanner, Vladimir I. Baranov
Принадлежит: PerkinElmer Health Sciences Inc

An analytical instrument has a sample introduction system for generating a stream of particles from a sample and an ionization system for receiving the particles. The ionization system is operable to atomize the particles received from the sample introduction system and ionize atoms from the atomized particles. The instrument has an ion pretreatment system and a magnetic sector mass analyzer comprising an array detector. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted to detect a transient signal of at least one element from individual particles from said stream by performing mass analysis on the ions from the atomized particles. The magnetic sector mass analyzer is adapted determine an amount of said at least one element from an individual particle using the transient signal detected during mass analysis of the ions from said individual particle.

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Номер записи: 5
14-06-2012 дата публикации

Reflector Time-of-Flight Mass Spectrometry with Simultaneous Space and Velocity Focusing

Номер: US20120145889A1
Автор: Marvin L. Vestal
Принадлежит: Virgin Instruments Corp

A time-of-flight mass spectrometer includes an ion source that generates ions. A two-field ion accelerator accelerates the ions through an ion flight path. A pulsed ion accelerator focuses the ions to a first focal plane where the ion flight time is substantially independent to first order of an initial velocity of the ions prior to acceleration. An ion reflector focuses ions to a second focal plane where the ion flight time is substantially independent to first order of an initial velocity of the ions prior to acceleration. An ion detector positioned at the second focal plane detects the ions. The two-field ion accelerator and the ion reflector cause the ion flight time to the ion detector for the ion of predetermined mass-to-charge ratio to be substantially independent to first order of both the initial position and the initial velocity of the ions prior to acceleration.

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Номер записи: 6
04-10-2012 дата публикации

Ion energy analyzer and methods of manufacturing the same

Номер: US20120248311A1
Автор: Barton Lane, Jianping Zhao, Lee Chen, Merritt Funk, Radha Sundararajan
Принадлежит: Tokyo Electron Ltd

A process by which an ion energy analyzer is manufactured includes processing a first substrate to form an entrance grid having a first channel and a first plurality of openings extending therethrough. A second substrate is processed to form a selection grid having a second channel therein and a second plurality of openings extending therethrough. A third substrate is processed to form an ion collector having a third channel therein. The entrance grid is operably coupled to, and electrically isolated from, the selection grid, which is, in turn, operably coupled to, and electrically isolated from, the ion collector.

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Номер записи: 7
04-10-2012 дата публикации

Methods of electrical signaling in an ion energy analyzer

Номер: US20120248322A1
Автор: Barton Lane, Jianping Zhao, Lee Chen, Merritt Funk, Radha Sundararajan
Принадлежит: Tokyo Electron Ltd

A method of generating a signal representing with an ion energy analyzer for use in determining an ion energy distribution of a plasma. The ion energy analyzer, used for determining an ion energy distribution of a plasma, includes a first grid and a second grid that is spaced away from and electrically isolated from the first grid. The first grid forms a first surface of the ion energy analyzer and is positioned to be exposed to the plasma. The first grid includes a first plurality of openings, which are dimensioned to be less than a Debye length for the plasma. A voltage source and an ion current meter are operably coupled to the second grid, the latter of which is configured to measure an ion flux onto the ion collector and to transmit a signal that represents the measured ion flux. The method includes selectively and variably biasing the second grid relative to the first grid.

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Номер записи: 8
31-01-2013 дата публикации

Electron Transfer Dissociation Device

Номер: US20130026358A1
Автор: Jeffery Mark Brown, Martin Raymond Green
Принадлежит: Micromass UK Ltd

A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.

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Номер записи: 9
21-03-2013 дата публикации

Ion Trap Mass Spectrometer

Номер: US20130068942A1
Автор: Verenchikov Anatoly
Принадлежит:

Electrostatic trap mass spectrometers are disclosed that may comprise at least two parallel sets of electrodes separated by a field-free space, wherein said at least two parallel electrode sets extend along a curved Z-direction locally orthogonal to said X-Y plane such that each of said two electrode sets define a volume with a two-dimensional electrostatic field in an X-Y plane and define either planar or torroidal field regions; means for adjusting the torroidal field regions to provide both (i) stable trapping of ions passing between said fields within said X-Y plane and (ii) isochronous repetitive ion oscillations within said X-Y plane such that the stable ion motion does not require any orbital or side motion; and an ion bounding means in the curved Z-direction configured to compensate time-of-flight distortions at Z-edges of the trap. 1115.-. (canceled)116. An electrostatic trap (E-trap) mass spectrometer comprising:at least two parallel sets of electrodes separated by a field-free space, wherein said at least two parallel electrode sets extend along a curved Z-direction locally orthogonal to said X-Y plane such that each of said two electrode sets define a volume with a two-dimensional electrostatic field in an X-Y plane and define either planar or torroidal field regions;means for adjusting the torroidal field regions to provide both (i) stable trapping of ions passing between said fields within said X-Y plane and (ii) isochronous repetitive ion oscillations within said X-Y plane such that the stable ion motion does not require any orbital or side motion; andan ion bounding means in the curved Z-direction configured to compensate time-of-flight distortions at Z-edges of the trap.117. A trap as set forth in claim 116 , wherein said Z-axis is curved at a constant radius to form torroidal field regions; and wherein an angle Φ between the curvature plane and said X-Y plane is selected from the group consisting of (i) 0 degrees; (ii) 90 degrees; and (iii) at or ...

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Номер записи: 10
25-04-2013 дата публикации

Early detection of thiamine deficiency

Номер: US20130102624A1
Автор: John V. Schloss
Принадлежит: Individual

A method is provided for determining the thiamine status of a human or animal based on the relative levels of thiamine and its metabolites. Certain embodiments of the present invention also provide methods for determining the effectiveness of a thiamine deficiency treatment.

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Номер записи: 11
02-05-2013 дата публикации

CHARGED PARTICLE ENERGY ANALYSERS AND METHODS OF OPERATING CHARGED PARTICLE ENERGY ANALYSERS

Номер: US20130105687A1
Автор: Cubric Dane
Принадлежит: SHIMADZU CORPORATION

A charged particle energy analyser () includes inner and outer cylindrically symmetric electrodes () arranged coaxially on a longitudinal axis (z-z) of the analyser. A position-sensitive detector () has a particle-receiving detection surface located off-axis, at a radial spacing from the longitudinal axis (z-z) less than the radius of the inner electrode (). Methods of operating the charged particle energy analyser in first and second order focussing modes are described. A position-sensitive detector () suitable for use in “parallel analysers” is described (FIGS. and ). 1. A charged particle energy analyser for simultaneous detection of charged particles within a range of energies , the analyser comprising:{'b': '1', 'inner and outer cylindrically symmetric electrodes arranged coaxially on a longitudinal axis, the inner cylindrically symmetric electrode having a circumference of radius R,'}biasing means for supplying voltage to the inner and outer cylindrically symmetric electrodes to create an electrostatic focussing field between the electrodes,a charged particle source for introducing charged particles into the electrostatic focussing field for analysis, anda detector for detecting charged particles focussed by the electrostatic focussing field,wherein the detector has a charged particle-receiving detection surface located off-axis, at a radial spacing from the longitudinal axis less than said radius RI.2. An analyser as claimed in wherein said inner cylindrically symmetric electrode has a truncated configuration and said charged particle-receiving surface of the detector is located at a truncation plane of the inner electrode.3. An analyser as claimed in wherein a segment of the inner cylindrically symmetric electrode is missing defining a gap between exposed claim 1 , longitudinally-extending edges of the electrode claim 1 , and said detector is mounted in said gap.4. An analyser as claimed in wherein said inner cylindrically symmetric electrode includes ...

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Номер записи: 12
09-05-2013 дата публикации

Wien filter

Номер: US20130112889A1
Автор: Weiming Ren, Xuedong Liu, Zhongwei Chen
Принадлежит: Hermes Microvision Inc

This invention provides a multi-pole type Wien filter, which acts more purely approaching its fundamentally expected performance. A 12-electrode electric device acts as an electric deflector,or acts as an electric deflector and an electric stigmator together. A cylindrical 4-coil magnetic device with a magnetic core acts as a magnetic deflector. Both can produce a dipole field while only incurring a negligibly-small 3rd order field harmonic. The magnetic core enhances the strength and more preciously regulates the distribution of the magnetic field originally generated by the coils. Then two ways to construct a Wien filter are proposed. One way is based on both of the foregoing electric and magnetic devices, and the other way is based on the foregoing electric device and a conventional magnetic deflector. The astigmatism in each of such Wien filters can be compensated by the electric stigmator of the electric device.

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Номер записи: 13
16-05-2013 дата публикации

Mass Spectrometer

Номер: US20130119247A1
Автор: Green Martin Raymond, Pringle Steven Derek, Wildgoose Jason Lee
Принадлежит: MICROMASS UK LIMITED

A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. 1. A method of detecting ions comprising:outputting a first signal and a second signal from an ion detector, wherein said first signal corresponds with a signal multiplied or amplified by a first gain and said second signal corresponds with a signal multiplied or amplified by a second, different gain;digitising said first signal to produce a first digitised signal and digitising said second signal to produce a second digitised signal;combining said first digitised signal and said second digitised signal to form a combined digitised signal;determining intensity and arrival time, mass or mass to charge ratio data from said combined digitised signal; andsumming said intensity and arrival time, mass or mass to charge ratio data with a plurality of other corresponding intensity and arrival time, mass or mass to charge ratio data to form a final spectrum.2. A method as claimed in claim 1 , further comprising processing said combined digitised signal to detect a set of peaks or ion arrival events.3. A method as claimed in claim 2 , wherein said step of determining said intensity and arrival time claim 2 , mass or mass to charge ratio data from said combined digitised signal further comprises determining intensity and arrival time claim 2 , mass or mass to charge ratio data for each or at least some peaks or ion arrival events in said set of peaks or ion arrival events.4. A method as claimed in claim 3 , wherein:(a) said step of determining said intensity and arrival time, mass or mass to charge ratio data further comprises marking or flagging ...

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Номер записи: 14
16-05-2013 дата публикации

METHOD AND A MASS SPECTROMETER AND USES THEREOF FOR DETECTING IONS OR SUBSEQUENTLY-IONISED NEUTRAL PARTICLES FROM SAMPLES

Номер: US20130119249A1
Автор: Niehuis Ewald
Принадлежит: ION-TOF TECHNOLOGIES GMBH

A method is used in a time-of-flight mass spectrometer for analysis of a first pulsed ion beam, the ions of which are disposed along the pulse direction, separated with respect to their ion masses. The ions of at least one individual predetermined ion mass or of at least one predetermined range of ion masses can be decoupled from the first pulsed ion beam, as at least one decoupled ion beam, and the first ion beam and the at least one decoupled ion beam are analyzed. 1. Method for operating a time-of-flight mass spectrometer for analysis of a first pulsed ion beam , the ions of which are disposed in a separated manner along the pulse direction with respect to their ion masses ,the improvement whereinthe ions of at least one individual predetermined ion mass or of at least one predetermined range of ion masses are decoupled from the first pulsed ion beam and form at least one decoupled ion beam, and the first ion beam and the at least one decoupled ion beam are analyzed.2. Method according to claim 1 , wherein the intensity of at least one decoupled ion beam or the intensity of the first ion beam is attenuated after decoupling.3. Method according to claim 1 , wherein at least one decoupled ion beam claim 1 , after attenuation of the first ion beam or of the decoupled ion beam claim 1 , is reunited with the first ion beam in order to form a common ion beam.4. Method according to claim 3 , wherein the ions of the decoupled ion beam and of the first ion beam are positioned in the common ion beam claim 3 , separated with respect to their masses.5. Method according to claim 1 , wherein at least one decoupled ion beam is analyzed separately from the first ion beam.6. Method according to claim 5 , wherein the first ion beam is analyzed with lower sensitivity than the decoupled ion beam which is analyzed separately from the first ion beam.7. Method according to claim 1 , wherein a common mass spectrum claim 1 , advantageously in portions claim 1 , is determined from the ...

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Номер записи: 15
23-05-2013 дата публикации

SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS

Номер: US20130126723A1
Автор: Charipar Nicholas Alan, Cooks Robert Graham, Garimella Sandilya Venkata, Harper Jason David, Ouyang Zheng
Принадлежит:

The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. 1. A system for analyzing a sample , the system comprising:an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure;an ion analysis device; andan ion transfer member operably coupled to a gas flow generating device, wherein the gas flow generating device produces a laminar gas flow that focuses and transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.2. The system according to claim 1 , wherein the ions are transferred over a distance of at least about five centimeters.3. The system according to claim 1 , wherein the ions are sampled over a area at least 4 centimeters by 3 centimeters.4. The system according to claim 1 , wherein the gas flow generating device is a pump.5. The system according to claim 1 , wherein the gas flow generating device is a gas jet of the ionizing source.6. The system according to claim 1 , further comprising an electric focusing lens device operably coupled to the ion transfer member to facilitate transfer of ions to the inlet of the ion analysis device.7. The system according to claim 6 , wherein the electric focusing element further focuses the ions at the center of the transfer member during the transfer.812-. (canceled)12. The system according to claim 1 , wherein the ion transfer member is a tube.13. The system according to claim 12 , wherein the tube is composed of ...

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Номер записи: 16
30-05-2013 дата публикации

POST-IONIZATION OF NEUTRALS FOR ION MOBILITY oTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES

Номер: US20130134305A1
Автор: Egan Thomas F., Lewis Ernest K., Schultz J. Albert, Waters Kelley L.
Принадлежит: IONWERKS, INC.

The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments. 1. An apparatus comprising:an ion source for repetitively or continuously generating ions and neutrals;a post-ionization device fluidly coupled to said ion source to post-ionize or fragment at least a fraction of said ions and neutrals;an ion mobility cell capable of receiving the directly desorbed ions and the post-ionized ions;an ion extractor, fluidly coupled to said ion-mobility device capable of extracting said ions;a mass spectrometer fluidly coupled to and accepting said ions and fragment ions from said ion extractor,a position sensitive ion detector fluidly coupled to said time-of-flight mass spectrometer to detect said ions and fragment ions;a timing controller in electronic communication with said ion source and said ion extractor said timing controller tracking and controlling the time of activation of said ion source and controlling the activation of the post-ionization device and activation of said ion extractor according to a predetermined ...

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Номер записи: 17
20-06-2013 дата публикации

Systems and Methods for Using Variable Mass Selection Window Widths in Tandem Mass Spectrometry

Номер: US20130153761A1
Автор: Bonner Ronald F., Tate Stephen A.
Принадлежит: DH Technologies Development Pte. Ltd.

Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample. 1. A system for analyzing a sample using variable mass selection window widths , comprising:a tandem mass spectrometer that includes a mass analyzer that allows variable mass selection window widths; anda processor in communication with the tandem mass spectrometer that instructs the tandem mass spectrometer to perform at least two fragmentation scans of a sample with different mass selection window widths.2. The system of claim 1 , wherein the processor further instructs the tandem mass spectrometer to adjust one or more different acquisition parameters for each different mass selection window.3. The system of claim 2 , wherein the acquisition parameters comprise one or more of an accumulation time claim 2 , a collision energy claim 2 , or a collision energy spread.4. The system of claim 1 , wherein the mass selection window widths are selected to contain the same number of mass values.5. The system of claim 1 , wherein the mass selection window widths are based on one or more properties of sample compounds.6. The system of claim 1 , wherein the one or more properties ...

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Номер записи: 18
27-06-2013 дата публикации

Method of mass-spectrometry and a device for its realization

Номер: US20130161508A1
Автор: Aldan Asanovich Sapargaliyev, Yerbol Aldanovich Sapargaliyev
Принадлежит: Individual

The present invention relates to the analytical electronics used to identify compositions and structures of substances, in particular, to the analyzers comprising at least one mass-spectrometer (MS) and may be applied in such fields as medicine, biology, gas and oil industry, metallurgy, energy, geochemistry, hydrology, ecology. Technical result provides the increase in MS resolution, gain in sensitivity, precision and measurement rates of substances compositions and structures concurrently with enhancement of analyzer functional capabilities, downsizing and mass reduction. In claimed invention the ion flux generation and its guiding are performed in off-axis single-flow mode; parallel multi-stage mode; through use of three-dimensional field with mean meridian surface including without limitation three-dimensional reflecting and dual-zoned reflecting modes or by method of multi-reflection arrays. Devices to implement the claimed method are embodied. Proposed schematic ion optical diagrams allow developing different MS types notable for their minimized material intensity and geometrical dimensions.

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Номер записи: 19
27-06-2013 дата публикации

METHOD AND APPARATUS FOR DETECTING AND IDENTIFYING GASES BY MEANS OF ION MOBILITY SPECTROMETRY

Номер: US20130161509A1
Автор: Münchmeyer Wolf, Ungethüm Bert, Walte Andreas
Принадлежит: AIRSENSE ANALYTICS GMBH

The invention relates to a method for identifying gases, which are ionized and the drift times of the positive and negative product ions through drift spaces are measured and the measured drift times are evaluated, wherein for measuring the drift times the product ions are accelerated to drift velocities by a resulting electrical field. It is provided that the positive and negative product ions move synchronously and in parallel in the same direction. 1. A method for identifying gases , wherein the gases to be identified are ionized and the drift times of the positive and negative product ions through drift spaces are measured and the measured drift times are evaluated , wherein for measuring the drift times the product ions are accelerated to drift velocities by a resulting electrical field , wherein the positive and negative product ions move synchronously and in parallel in the same direction.2. The method of claim 1 , wherein the product ions are injected into the drift spaces perpendicular to their preferred direction.3. A device for identifying gases claim 1 , which comprises at least two drift tubes claim 1 , wherein each of the drift tubes has at least one detector for detecting product ions claim 1 , wherein at least two drift tubes are arranged in parallel with each other and are delimited claim 1 , on one hand claim 1 , by a common intake system and claim 1 , on the other hand claim 1 , by at least one detector.4. The device according to claim 3 , wherein an ion guide electrode arrangement dividing the drift tube into a common reaction chamber and at least two drift spaces is arranged in each of the drift tubes claim 3 , wherein an ion source is disposed in the common reaction chamber and a respective shielding grid is disposed in each of the drift spaces.5. The device according to claim 3 , wherein the drift spaces comprise alternatingly arranged drift electrodes claim 3 , wherein each drift electrode is electrically connected around the drift spaces and ...

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Номер записи: 20
04-07-2013 дата публикации

Method of Mass Spectrometry and Mass Spectrometer Using Peak Deconvolution

Номер: US20130168546A1
Автор: Denny Richard, Gilbert Anthony James, Green Martin Raymond, Pringle Steven Derek, Richardson Keith, Skilling John, Wildgoose Jason Lee
Принадлежит: MICROMASS UK LIMITED

A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum. 1. A method of mass spectrometry comprising:providing a Time of Flight mass analyser comprising an electrode for accelerating ions into a time of flight region and an ion detector arranged to detect ions after said ions have passed through said time of flight region;digitising a first signal output from said ion detector to produce a first digitised signal;de-convoluting said first digitised signal and determining one or more first ion arrival times and one or more first ion arrival intensities associated with said first digitised signal;digitising a second signal output from said ion detector to produce a second digitised signal;de-convoluting said second digitised signal and determining one or more second ion arrival times and one or more second ion arrival intensities associated with said second digitised signal;digitising third and further signals output from said ion detector to produce third and further digitised signals;de-convoluting said third and further digitised signals and determining one or more third and further ion arrival times and one or more third and further ion arrival intensities associated with said third and further digitised signals; andcombining said one or more first ion arrival times, said one or more second ion arrival times and ...

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Номер записи: 21
04-07-2013 дата публикации

Time-Of-Flight Mass Spectrometer

Номер: US20130168547A1
Автор: Miyauchi Shinji, NISHIGUCHI Masaru, Ueno Yoshihiro
Принадлежит: SHIMADZU CORPORATION

Provided is a time-of-flight mass spectrometer having a reflectron which eliminates energy dependency of the flight time of ions having the same m/z while ensuring a high degree of design freedom. An electric field created by the reflectron is virtually divided into a decelerating region for decelerating ions and a reflecting region for reflecting ions. For an ion having a mass-to-charge ratio which has departed with initial energy higher than U, the total flight time required for the ion to travel through a free-flight region and the decelerating region into the reflecting region and return will be equal to the total flight time required for an ion of the same mass-to-charge ratio to make a round trip in which the ion turns around at a point of the reference potential value at the boundary between the decelerating region and the reflecting region or in the decelerating region. 3. The time-of-flight mass spectrometer according to claim 2 , wherein:{'sub': 1', '2, 'd=d=d; and'}d is within the range of 0.01 Подробнее

Номер записи: 22
01-08-2013 дата публикации

Mass spectrometer with a wide dynamic range

Номер: US20130193320A1
Автор: Alberto Tommaso Crotti, Alessandro Casilli, Andrew Hoffman, Manuela Bergna
Принадлежит: Dani Instruments SpA

A mass spectrometer with a wide dynamic range, having:—a source ( 2 ) of ion beams,—an analyzer ( 4 ) for the ion beams generated by said source ( 2 ),—a detector ( 6 ) for the ions separated by said analyzer ( 4 ),—a treatment stage ( 8 ) for the analogue signal A generated by said detector, to obtain two separate signals A 1= mA and A 2 =nA, where m>n, characterised by comprising:—an analogue/digital converter ( 10 ) for converting both said analogue signals A 1 and A 2 into two numerical values D 1 and D 2, —a controller ( 12 ) which receives both the numerical values D 1 and D 2 as input, and provides as output a single value equal to D 1 if D 1 is less than the end-of-scale value of the converter ( 10 ), or a value equal to (m/n)D 2 if D 1 is equal to the end-of-scale value of the converter.

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Номер записи: 23
15-08-2013 дата публикации

MOLECULAR ION ACCELERATOR

Номер: US20130206975A1
Автор: CHEN Chung-Hsuan, HSU Nien-Yeen, LIN Jung-Lee, Wang Yi-Sheng
Принадлежит: Academia Sinica

A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte. 157-. (canceled)58. A linear pulsed-voltage ion acceleration apparatus for accelerating an ion of interest , the apparatus comprising:a linear series of from 5 to 1000 electrodes, wherein the electrodes are plates, cylinders or boxes comprising openings through which the ion of interest can pass;a series of two or more function generators, wherein each function generator is independently connected to one or more of the electrodes, and wherein each function generator is capable of supplying a pulsed voltage based on the duration of the ion of interest through its flight path;wherein the apparatus is configured to accelerate the ion of interest to an energy of up to 10 MeV per charge on the ion of interest.591. The apparatus of claim , wherein the apparatus is enclosed in a vacuum chamber.601. The apparatus of claim , wherein the electrodes are spaced apart greater than a distance for arcing.611. The apparatus of claim , comprising a series of 2 , 3 , 4 , or 5 function generators , wherein each function generator is independently connected to one or more of the electrodes , and wherein adjacent electrodes are connected to different function generators.621. The apparatus of claim , comprising two function generators , wherein each function generator is independently connected to one or more of the electrodes , wherein adjacent electrodes are connected to different function generators , and wherein each function generator is connected to every second electrode.631. The apparatus of claim , comprising three function generators , wherein each function generator is ...

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Номер записи: 24
15-08-2013 дата публикации

MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA

Номер: US20130206981A1
Автор: Clarke Nigel J., Ghoshal Amit, Goldman Mildred M.
Принадлежит: Quest Diagnostics Investment Incorporated

Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. 1. A method for determining in a sample , by mass spectrometry , the amounts of at least three analytes selected from the group consisting of pregnenolone , 17-OH pregnenolone , progesterone , 17-OH progesterone , dehydroepiandrosterone (DHEA) , androstenedione , testosterone , 11-deoxycortisol , deoxycorticosterone , and cortisol , the method comprising:subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the analytes, wherein the analytes are not derivatized prior to ionization;determining, by tandem mass spectrometry, the amounts of the one or more ions from each of the analytes; andusing the determined amounts of the one or more ions to determine the amount of each of the analytes in the sample.2. The method of claim 1 , wherein the analytes comprise cortisol claim 1 , androstenedione and 17-OH progesterone.3. The method of claim 1 , wherein the analytes comprise cortisol claim 1 , androstenedione and progesterone.4. The method of claim 1 , wherein the analytes comprise cortisol claim 1 , deoxycorticosterone and 17-OH progesterone.5. The method of claim 1 , wherein the analytes comprise testosterone claim 1 , androstenedione and dehydroepiandrosterone (DHEA).6. The method of claim 1 , wherein the analytes comprise four or more analytes.7. The ...

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Номер записи: 25
15-08-2013 дата публикации

ION MOBILITY TUBE

Номер: US20130206982A1
Автор: Peng Hua, Zhang Xiuting, ZHANG Yangtian, Zheng Xiaoyong
Принадлежит: Nutech Company Limited

An ion mobility tube comprises an ionization source chamber having a center ionization source chamber hole, an ion door, a mobility region unit having a center mobility tube chamber, a constraining grid, and a Faraday disk, and the ionization source chamber, the ion door, the mobility region unit, the constraining grid, and the Faraday disk are laminated together in sequence in a front-rear direction, wherein the mobility region unit comprises a first insulator and first metal electrode sheets concentrically fixed to a front surface and a back surface of the first insulator respectively. The mobility region unit comprises the first insulator and the first metal electrode sheets which are integral. Therefore, the ion mobility tube is advantageous in simplified manufacturing, and convenient for detachment and assembly. 1. An ion mobility tube , comprising: an ionization source chamber having a center ionization source chamber hole , an ion door , a mobility region unit having a center mobility tube chamber , a constraining grid , and a Faraday disk , and the ionization source chamber , the ion door , the mobility region unit , the constraining grid , and the Faraday disk are laminated together in sequence in a front-rear direction , wherein the mobility region unit comprises a first insulator and first metal electrode sheets concentrically fixed to a front surface and a back surface of the first insulator respectively.2. The ion mobility tube of claim 1 , characterized in that the first insulator is formed with a first electronic element accommodating hole located on radial outsides of the first metal electrode sheets.3. The ion mobility tube of claim 2 , characterized in that the first insulator is further formed with a first wiring hole located on the radial outsides of the first metal electrode sheets.4. The ion mobility tube of claim 1 , characterized in that the ionization source chamber comprises a second insulator and second metal electrode sheets ...

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Номер записи: 26
15-08-2013 дата публикации

Transmission Electron Microscope

Номер: US20130206987A1
Автор: Omoto Kazuya
Принадлежит: JEOL LTD.

A transmission electron microscope () includes an electron beam source (), an illumination lens (), an objective lens (), an intermediate lens system (), a pair of transfer lenses () located behind the intermediate lens system (), and an energy filter () for separating the electrons of the beam L transmitted through the specimen (S) according to energy. The transfer lenses () transfer the first image to the entrance crossover plane (S) of the energy filter () and to transfer the second image to the entrance image plane (A) of the filter (). An image plane (A) is formed between the first transfer lens () and the second transfer lens (). 1. A transmission electron microscope comprising:an electron beam source producing an electron beam;an illumination lens via which the electron beam from the electron beam source is directed at a specimen;an objective lens for forming a focused first image from the electron beam transmitted through the specimen;an intermediate lens system for forming a focused second image from the electron beam transmitted through the specimen;a pair of transfer lenses disposed behind the intermediate lens system, the pair of transfer lenses being made up of a first transfer lens and a second transfer lens; andan energy filter for separating the electrons of the electron beam transmitted through the specimen according to energy,wherein the transfer lenses act to transfer the first image to an entrance crossover plane of the energy filter and to transfer the second image to an entrance image plane of the energy filter; andwherein an image plane is formed between the first transfer lens and the second transfer lens of the pair of transfer lenses.2. A transmission electron microscope as set forth in claim 1 , wherein a detector for detecting electrons scattered by the specimen is disposed at said image plane between said first and second transfer lenses.3. A transmission electron microscope as set forth in claim 1 , wherein an entrance aperture for ...

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Номер записи: 27
19-09-2013 дата публикации

Method of Mass Selecting Ions and Mass Selector

Номер: US20130240725A1
Автор: MAKAROV Alexander A.
Принадлежит:

A method of selecting ions of interest from a beam of ions using an analyser, the method comprising: (i) providing an analyser comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis z, each system comprising one or more electrodes, the outer system surrounding the inner; (ii) causing the beam of ions to fly through the analyser along a main flight path in the presence of an analyser field so as to undergo within the analyser at least one full oscillation in the direction of the analyser axis whilst orbiting about or oscillating between one or more electrodes of the inner field defining electrode system; (iii) providing one or more sets of electrodes adjacent the main flight path; (iv) constraining the arcuate divergence from the main flight path of ions of interest by applying one set of voltages to one or more of the sets of electrodes adjacent the main flight path when the ions of interest are in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path and applying one or more different sets of voltages to the said one or more sets of electrodes adjacent the main flight path when the ions of interest are not in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path; and: (v) ejecting the ions of interest from the analyser. Also provided is a charged particle analyser comprising the two opposing ion mirrors comprising inner and outer field-defining electrode systems elongated along an analyser axis z, and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyser whilst the beam orbits around the axis z, the analyser further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive ...

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Номер записи: 28
19-09-2013 дата публикации

METHOD AND SYSTEM FOR IMPROVING CHARACTERISTIC PEAK SIGNALS IN ANALYTICAL ELECTRON MICROSCOPY

Номер: US20130240728A1
Автор: Albiol Sonia Estrade, Cardona Lluis Yedra, Corsellas José Manuel Rebled, Kim Steven, Martinez Francisca Peiro, Nicolopoulos Stavros, Serra Joaquin Portillo, Weiss Jon Karl
Принадлежит:

A method and system are disclosed for improving characteristic peak signals in electron energy loss spectroscopy (EELS) and energy dispersive x-ray spectroscopy (EDS) measurements of crystalline materials. A beam scanning protocol is applied which varies the inclination, azimuthal angle, or a combination thereof of the incident beam while spectroscopic data is acquired. The method and system may be applied to compositional mapping. 1. A method for obtaining spectroscopic data comprising: configuring an electron beam to impinge on a location of the sample comprising a region of crystalline material;', 'characterized in that the method further comprises:', 'applying an incident beam scanning protocol that maintains the beam impinging substantially on the sample location while varying over time one or both of the incident beam inclination angle and azimuthal angle; and', 'acquiring a set of spectroscopic data while the incident beam scanning protocol is being applied., 'furnishing in an electron microscope a sample comprising crystalline material; and'}2. The method of wherein the spectroscopic data set comprises energy-resolved x-ray data acquired from x-rays emitted from the crystalline region.3. The method of claim 1 , wherein the electron microscope is a transmission electron microscope and wherein the spectroscopic data set comprises energy loss data acquired from a beam exiting the sample claim 1 , further comprising applying a complementary beam scanning protocol to the exit beam that substantially removes any time-dependent motion of the exit beam arising from the incident beam scanning protocol.4. The method of further comprising the step of extracting quantitative compositional information from the spectroscopic data set.5. The method of wherein the incident beam scanning protocol comprises precessing the incident beam at a substantially constant inclination angle.7. The method of claim 2 , wherein an inclination angle is associated with the incident beam ...

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Номер записи: 29
26-09-2013 дата публикации

Method of Mass Separating Ions and Mass Separator

Номер: US20130248702A1
Автор: Alexander A. Makarov
Принадлежит: Thermo Fisher Scientific Bremen GmbH

A method of separating ions according to their time of flight is provided comprising: a. providing an analyser comprising two opposing ion mirrors, each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis with the outer field-defining electrode system surrounding the inner field-defining electrode system and creating therebetween an analyser volume; b. injecting ions into the analyser volume or creating ions within the analyser volume so that they separate according to their time of flight as they travel along a main flight path whilst undergoing a plurality of axial oscillations in the direction of the analyser axis and a plurality of radial oscillations whilst orbiting about one or more inner field-defining electrodes; c. the plurality of axial oscillations and plurality of radial oscillations causing the separated ions to intercept an exit port after a predetermined number of orbits. Also provided is an analyser for performing the method, comprising: the two opposing ion mirrors which abut at a first plane, wherein the outer field-defining electrode system of one mirror comprises two sections, the sections abutting at a second plane, comprising a first section between the first plane and the second plane, and a second section adjacent the first section and wherein the first section has at least a portion which extends radially from the analyser axis a greater extent than an adjacent portion of the second section at the second plane.

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Номер записи: 30
26-09-2013 дата публикации

Spectrometer Apparatus

Номер: US20130248703A1
Автор: William Angus Munro
Принадлежит: Smiths Detection Watford Ltd

An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude of an ion peak detected at the far end of the drift region.

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Номер записи: 31
17-10-2013 дата публикации

MEASURING THE POPULATIONS IN EACH HYPERFINE GROUND STATE OF ALKALI ATOMS IN A VAPOR CELL WHILE LIMITING THE CONTRIBUTION OF THE BACKGROUND VAPOR

Номер: US20130270434A1
Автор: ANDERSON Mike, Luey Ben, Nelson Karl D., Salit Kenneth
Принадлежит: HONEYWELL INTERNATIONAL INC.

A method for measuring the population of atoms in a vapor cell comprises collecting a sample of atoms, applying radio frequency (RF) spectroscopy to the sample such that a first portion of the atoms are in an upper ground state and a second portion of the atoms are in a lower ground state, and applying light to the sample to produce a first fluorescence such that all atoms are left in the lower ground state. The method further comprises measuring a population of the atoms in the upper ground state based on the first fluorescence, applying an RF pulse to the sample to transfer the atoms in the lower ground state to the upper ground state, and applying light to the sample after the RF pulse is applied to produce a second fluorescence. A population of all the atoms in the sample is then measured based on the second fluorescence. 1. A method for measuring the population of atoms in a vapor cell , the method comprising:collecting a sample of atoms from the vapor cell;applying radio frequency (RF) spectroscopy to the sample of atoms such that a first portion of the atoms are in an upper ground state and a second portion of the atoms are in a lower ground state;applying light to the sample of atoms to produce a first fluorescence of the atoms such that all the atoms in the sample are left in the lower ground state;measuring a population of the atoms in the upper ground state based on the first fluorescence of the atoms;applying an RF pulse to the sample of atoms to transfer the atoms in the lower ground state to the upper ground state;applying light to the sample of atoms after the RF pulse is applied to produce a second fluorescence of the atoms; andmeasuring a population of all the atoms in the sample based on the second fluorescence of the atoms.2. The method of claim 1 , wherein the sample of atoms is collected in a magneto-optic trap.3. The method of claim 2 , wherein the magneto-optic trap is part of a physics package in an atomic clock.4. The method of claim 1 , ...

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Номер записи: 32
24-10-2013 дата публикации

ANALYSIS APPARATUS AND ANALYSIS METHOD

Номер: US20130277549A1
Автор: Kimura Hajime, KIYOMURA Shunsuke
Принадлежит: Semiconductor Energy Laboratory Co., Ltd

A compound contained in a sample is analyzed more accurately. Provided is an analysis method using TOF-SIMS in which first spectral data is obtained by irradiating the sample with a first primary ion, second spectral data is obtained by irradiating the sample with a second primary ion, and a surface of the sample is etched by an ion and then the surface of the sample is irradiated with the first primary ion or the second primary ion. The first primary ion is more likely to break a molecular structure of a molecule contained in the sample than the second primary ion. 1. An analysis apparatus comprising:a first ion source; anda second ion source; anda detector for a mass number,wherein the first ion source comprises a function of irradiating a sample with a first primary ion, andwherein the second ion source comprises a function of etching the sample in a depth direction and a function of irradiating the sample with a second primary ion.2. The analysis apparatus according to claim 1 ,wherein the second primary ion comprises a cluster ion including a plurality of atoms, andwherein a second number of atoms of the second primary ion is larger than a first number of atoms of the first primary ion.3. The analysis apparatus according to claim 1 ,wherein first mass spectral data are detected when the sample is irradiated with the first primary ion,wherein second mass spectral data are detected when the sample is irradiated with the second primary ion, andwherein a first number of fragment peaks of the first mass spectral data is larger than a second number of fragment peaks of the second mass spectral data.4. An analysis method using TOF-SIMS claim 1 , comprising the steps of:obtaining first mass spectral data by irradiating a sample with a first primary ion;obtaining second mass spectral data by irradiating the sample with a second primary ion; andevaluating components of the sample by comparing the first mass spectral data with the second mass spectral data,wherein a first ...

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Номер записи: 33
31-10-2013 дата публикации

CHROMATOGRAPH MASS SPECTROMETER

Номер: US20130284919A1
Автор: Mukaibatake Kazuo
Принадлежит:

When an SIM measurement for ions originating from a target component separated by a chromatograph is performed, the measurement is performed while the mass-resolving power is switched among a plurality of levels of resolving power, with the mass-to-charge ratio fixed at a target value (S), and an extracted ion chromatogram is created based on each of data obtained corresponding to respective mass-resolving powers (S). After the extracted ion chromatograms are obtained, an S/N ratio is calculated for a peak of the target component on each of the chromatograms (S), and a mass-resolving power which yields the highest S/N ratio is selected (S). The selected mass-resolving power is set as the mass-resolving power in the subsequent measurements of the same target component in the same kind of sample (S), and the quantitative determination of the target component is performed using the extracted ion chromatogram obtained with the selected mass-resolving power (S). 1. A chromatograph mass spectrometer having a chromatograph in which components of a sample are separated in a temporal direction and a mass spectrometer with a quadrupole mass filter in which ions originating from the components of the sample separated by the chromatograph are separated according to mass-to-charge ratios thereof , the chromatograph mass spectrometer comprising:a) a quadrupole driver for applying a direct-current voltage and a radio-frequency voltage to each electrode constituting the quadrupole mass filter, so as to selectively allow an ion having a specific mass-to-charge ratio to pass through;b) a controller for controlling the quadrupole driver so as to change the applied voltages in such a manner that a mass-resolving power is sequentially switched among a plurality of previously determined levels of mass-resolving power when a target ion originating from a target component is allowed to pass through the quadrupole mass filter and be detected; andc) a chromatogram creator for creating an ...

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Номер записи: 34
31-10-2013 дата публикации

Time-of-Flight Mass Spectrometer and Data Compression Method Therefor

Номер: US20130289892A1
Автор: Satoh Takaya
Принадлежит: JEOL LTD.

A data compression method for use by a flight-of-time mass spectrometer reduces the amount of digital data, which are converted from mass spectra by a digitizer, by thinning out their data points without reducing the amount of information over the whole range. The mass spectrometer has a data processing unit including data reduction means which reduces the number of data points of digital data delivered from the digitizer in response to an electrical signal indicative of ions based on a previously entered data table such that m/z regions partitioned by given flight times or given ink are set to have different numbers of data points. 1. A time-of-flight mass spectrometer comprising:an ion source for ionizing a sample;a time-of-flight mass analyzer for causing generated ions to travel and mass-separating the ions according to their mass-to-charge ratio;a detector for detecting the ions mass-separated by the mass analyzer according to their mass-to-charge ratio and outputting an electrical signal;a digitizer for converting the electrical signal outputted from the detector into digital form; anda processing unit to which digital data from the digitizer is supplied,wherein said processing unit has (1) data compression means for reducing the number of data points of the digital data such that m/z regions partitioned by given flight times or given m/z are set to have different numbers of data points and (2) storage means in which the digital data whose number of data points has been reduced by the data compression means are stored over a long term.2. A time-of-flight mass spectrometer as set forth in claim 1 , wherein said data compression means reduces the number of data points by taking an average of flight times claim 1 , m/z values claim 1 , or ion intensity values between preset numbers of data points.3. A time-of-flight mass spectrometer as set forth in claim 1 , wherein the number of data points of the digital data that is set to different values for the m/z regions ...

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Номер записи: 35
07-11-2013 дата публикации

SCANNING ELECTRON MICROSCOPE AND LENGTH MEASURING METHOD USING THE SAME

Номер: US20130292568A1
Автор: Bizen Daisuke, Ezumi Makoto, Makino Hiroshi, Tanaka Junichi
Принадлежит:

This electron scanning microscope comprises an electron source (), electron optical systems () for exposing a sample () to primary electron beams (), an electron detector () for detecting signal electrons () emitted from the sample, and a deceleration electrical field-type energy filter (). The deceleration electrical field-type energy filter has a conductor thin film () for distinguishing the energy of signal electrons. With this configuration, it is possible to realize a scanning electron microscope having a deceleration electrical field-type energy filter with which high energy resolution is obtained, even in a case where the scanning electron microscope has a retarding optical system. 1. A scanning electron microscope comprising an electron source , a deflector for deflecting a primary electron beam emitted from the electron source , a condenser lens for converging the primary electron beam deflected by the deflector , an electron detector for detecting signal electrons emitted due to irradiation of a sample with the primary electron beam converted by the condenser lens , and a deceleration electrical field-type energy filter which is placed on the sample side than the electron detector and discriminates the energy of the signal electrons ,wherein the deceleration electrical field-type energy filter has a conductor thin film for energy discrimination of the signal electrons.2. The scanning electron microscope according to claim 1 , further comprising deceleration means for decelerating the primary electron beam applied to the sample.3. The scanning electron microscope according to claim 1 , wherein the conductor thin film has at least any of C claim 1 , graphene claim 1 , Al claim 1 , Au claim 1 , Cu and W claim 1 , and the thickness thereof is in the range of greater than or equal to 0.3 nm and less than or equal to 50 nm.4. The scanning electron microscope according to claim 1 , wherein the conductor thin film is a multilayer film of an insulator and a ...

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Номер записи: 36
14-11-2013 дата публикации

TANDEM MASS SPECTROMETRY USING COMPOSITE WAVEFORMS

Номер: US20130299693A1
Автор: Londry Frank A., Xia Yu
Принадлежит:

A tandem mass spectrometer system and method are described, where a composite voltage waveform is applied to so as to trap ion having selected m/z. The trapped ions may be subject to collision induced ionization dissociation (CID) by a selectable discrete frequency voltage waveform positioned so as to be in a notch in a broadband waveform. The resultant ion products may be trapped using a second notch having a center frequency corresponding to the ion product to be trapped. The process may be repeated so as to increase the amount of ions produced, or the process a first resultant ion product to yield a second resultant in product, which may be trapped. 1. An apparatus for analyzing ions , comprising:a mass spectrometer, and 'wherein the radio frequency generator is operated to provide a first RF waveform having a controllable frequency range and an amplitude, and a notch in the frequency range having a controllable frequency and amplitude.', 'a radio frequency generator,'}2. The apparatus of claim 1 , wherein the radio frequency generator is operated to provide a second RF waveform having a controllable frequency and amplitude.3. The apparatus of claim 2 , wherein the frequency of the second RF waveform is controlled to corresponds to the notch frequency of the first RF waveform.4. The apparatus of claim 1 , wherein the amplitude of the notch in the first RF waveform is selected so as to avoid dissociation of ions present in the portion of the mass spectrometer to which the RF waveform is applied.5. The apparatus of claim 2 , wherein the first RF waveform and the second RF waveform are applied simultaneously.6. The apparatus of claim 1 , wherein the first RF waveform and the second RF waveform are applied sequentially.7. The apparatus of claim 1 , wherein the first RF waveform is a broadband waveform.8. The apparatus of or claim 1 , wherein notch in the first waveform has a bandwidth of between about 4 kHz and about 8 kHz.9. The apparatus of claim 1 , or claim 1 , ...

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Номер записи: 37
14-11-2013 дата публикации

MASS SPECTROMETER

Номер: US20130304394A1
Автор: YAMAGUCHI Shinichi
Принадлежит: SHIMADZU CORPORATION

A product ion spectrum is created on the basis of MSanalysis data respectively obtained for a parent compound and a metabolite. Additionally, a neutral loss spectrum, in which the mass of each product ion is replaced with a mass difference between the mass of the product ion and that of a precursor ion, is created. Then, a common peak having the same mass on the neutral loss spectrums of both the parent compound and the metabolite is extracted, and a complementary peak appearing on the product ion spectrum of the metabolite is extracted; this peak appears at a position corresponding to the difference between the mass of the common peak and that of the precursor ion. The ion corresponding to the complementary peak is designated as a precursor ion for the next MSanalysis, and this MSanalysis is performed. 1. A mass spectrometer capable of an MSanalysis (where n is an integer greater than two) , which is characterized by comprising:{'sup': m-1', 'm-1, 'a) a mass spectrum creating means for creating an MSspectrum (where m is an integer greater than two and no greater than n) based on mass analysis data obtained by an MSanalysis performed for each of first and second components;'}{'sup': m-1', 'm-1', 'm-1, 'b) a mass-difference spectrum creating means for calculating, for each of the two MSspectrums, a mass difference between a mass of each peak among some or all of peaks appearing on the MSspectrum and a mass of a precursor ion, and for creating an MSmass-difference spectrum having a peak at each of the calculated mass differences;'}{'sup': 'm-1', 'c) a common-peak extracting means for extracting a peak having a same mass in the two MSmass-difference spectrums relating to the first component and the second component;'}{'sup': 'm-1', 'd) a complementary-peak extracting means for extracting a complementary peak on the MSspectrum relating to the first component and/or the second component, the complementary peak corresponding to a mass difference between the mass of the ...

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Номер записи: 38
21-11-2013 дата публикации

EFFICIENT DETECTION OF ION SPECIES UTILIZING FLUORESCENCE AND OPTICS

Номер: US20130306855A1
Автор: PAPANASTASIOU DIMITRIS, RAPTAKIS EMMANUEL
Принадлежит: FASMATECH SCIENCE & TECHNOLOGY SA

The present disclosure relates to mass spectrometers and ion mobility spectrometers and methods for utilizing them and, in particular, to efficient detection of large size ionic species by attaching fluorescent agents to such species and utilizing high intensity light and appropriate optics to define a detection plane. A mechanism to detect fluorescence photons with high efficiency is coupled thereto. In an exemplary embodiment, a mass or ion mobility analyzer is utilized to separate fluorescent ionic species in space or time. The ionic species absorb and re-emit photons as they transverse the detection plane. The photons are directed to a photon detector that generates an electric signal that defines time or position (or position and time of intersection) of ionic species with the detection plane. 1. A method of identifying particle properties in an apparatus including an ion conduit and a detection area at or near an end of the ion conduit that is illuminated by light radiation such that fluorescent agents attached to particles emit photons as they pass through the detection area , and further including detectors that measure time and position , comprising:transmitting a particle to which have been attached fluorescent agents through the ion conduit; anddetermining flight time and position information in response to collected measurements of time and position as the particle having attached fluorescent agents travels through the ion conduit.2. An apparatus comprising:means for generating a source of fluorescent particles;means to separate the particles, as a function of time and/or space, which separation results from uniqueness of particle properties;means to illuminate a detection area with light radiation; andmeans to detect the time and/or position of photons emitted by the particles as they cross the detection area.3. The apparatus of claim 2 , where the photons are emitted in any direction from particles as the particles cross the detection area claim 2 , ...

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Номер записи: 39
21-11-2013 дата публикации

Tandem Time-of-Flight Mass Spectrometer and Method of Mass Spectrometry Using the Same

Номер: US20130306859A1
Автор: Takaya Satoh
Принадлежит: Jeol Ltd

A tandem time-of-flight mass spectrometer is offered which can perform MS/MS measurements efficiently without sample wastage by ingeniously combining flight time ranges required by precursor ions with measurement times actually taken to measure the precursor ions. The mass spectrometer has an array input means for causing the flight time ranges required by selected precursor ions and the actually taken measurement times in which the precursor ions are measured to be appropriately arrayed in a time-sequential manner such that the flight time ranges and measurement times do not overlap each other.

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Номер записи: 40
28-11-2013 дата публикации

QUADRUPOLE MASS SPECTROMETER

Номер: US20130313427A1
Автор: Mizutani Shiro
Принадлежит:

A quadrupole power source which applies a voltage to each electrode (-) of a quadrupole mass filter () receives inputs of an m/z-axis correction coefficient Mcomp and a V-voltage correction coefficient Vcomp in addition to a power supply controlling voltage Qcont according to the m/z of a target ion. Vcomp is a reciprocal of the ratio by which a frequency is changed, while Mcomp is the square of the ratio by which the frequency is changed. In a detection gain adjuster section (C), a multiplier () multiplies an output Vdet′ of a V-voltage adjusting amplifier () by Vcomp whereby the radio-frequency voltage produced by a radio-frequency power supply section (A) is maintained at the same level even when the set frequency of a signal generator () is changed in order to tune an LC resonance circuit. 1. A quadrupole mass spectrometer including a quadrupole mass filter composed of a plurality of electrodes , a quadrupole power source for applying a predetermined voltage to each of the electrodes of the quadrupole mass filter so as to selectively allow an ion having a specific mass-to-charge ratio to pass through the quadrupole mass filter , and a controller for giving the quadrupole power source an instruction on a target voltage corresponding to the mass-to-charge ratio of a target ion ,the quadrupole power source having a wave detector for detecting a radio-frequency voltage applied to the quadrupole mass filter and generating a DC detection output, a detection output adjuster for adjusting a gain of the detection output generated by the wave detector, a radio-frequency power source which includes a signal generator for generating a radio-frequency signal with a variable frequency and which produces a radio-frequency voltage whose amplitude is based on a comparison between an output of the detection output adjuster and the target voltage and whose frequency is equal to or proportional to the frequency of the radio-frequency signal, a direct-current power source for ...

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Номер записи: 41
12-12-2013 дата публикации

METHOD AND DEVICE FOR INCREASING THE THROUGHPUT IN TIME-OF-FLIGHT MASS SPECTROMETERS

Номер: US20130327935A1
Автор: Wiedenbeck Michael
Принадлежит: HELMHOLTZ-ZENTRUM POTSDAM DEUTSCHES GEOFORSCHUNGSZENTRUM - GFZ STIFTUN DES ÖFFENTLICHE

The invention relates to a method for increasing the throughput in time-of-flight mass spectrometers as well as a device for conducting the method. 1. A method for increasing the throughput in time-of-flight mass spectrometers , whereinthe individual ion packets, which the extractor admits into the drift zone, are deflected inside the drift zone by means of at least one deflecting device disposed in the drift zone, for the generation of electric fields that vary in time and intensity, andthe deflection is detected as additional information together with the flight time of the ions by means of a detector.2. The method according to claim 1 , further characterized in that the electric field is selected such that the site at which the deflected ion packet strikes the detector is pre-determined.3. The method according to claim 1 , further characterized in that the time variability of the electric field is coordinated with the admission control of the extractor.4. The method according to claim 1 , further characterized in that the intensity of the electric field is selected such that a pre-determined deflection is ensured for each individual ion packet.5. The method according to claim 1 , further characterized in that the electric field acts on the ion packets within the drift zone in the direct vicinity of the extractor claim 1 , and electric fields do not act in the further course of the drift zone.6. The method according to claim 1 , further characterized in that the deflecting device that generates the electric field is disposed along the x or y-axis or along the x and y-axes claim 1 , the z-axis running along the direction of the drift zone.7. The method according to claim 6 , further characterized in that the deflecting device that generates the electric field is disposed along the x-axis and the y-axis in different regions of the drift zone.8. The method according to claim 1 , further characterized in that the intensity of the electric field is selected such that ...

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Номер записи: 42
19-12-2013 дата публикации

TRIPLE QUADRUPOLE MASS SPECTROMETER

Номер: US20130334415A1
Автор: Okumura Daisuke, Sugawara Hiroshi
Принадлежит: SHIMADZU CORPORATION

A high-quality mass spectrum is provided with alleviated mass/charge axis deviation in a triple quadrupole mass spectrometer even when executing a high-speed mass scan with MS/MS analysis. Mass calibration tables which denote relations between m/z and a mass deviation value which scan speed is a parameter are prepared separately for use in MS analyses without involving dissociation operations and MS/MS analyses with involving dissociation operations. According to a measuring mode, such as a product ion scan measurement or a neutral loss scan measurement, when performing MS/MS analysis, a mass deviation value for the minimum scan speed in a table is used for a quadrupole where the selected m/z is fixed, and a mass deviation value for a designated scan speed in a table is used for a quadrupole where the mass scan is performed, thus controlling the operations of each of a pre-stage and a post-stage quadrupoles. 1. A triple quadrupole mass spectrometer , comprising:an ion source, ionizing a sample;a pre-stage quadrupole, for selecting, from various ions generated by the ion source, first ions having a first specific mass-to-charge ratio as precursor ions;a collision cell, performing a dissociation operation to dissociate the precursor ions;a post-stage quadrupole, for selecting second ions having a second specific mass-to-charge ratio from various product ions generated by the dissociation operation;a detector, detecting the second ions passing through the post-stage quadrupole;a calibration information memory unit to store in advance mass calibration information showing a relationship between a mass-to-charge ratio and calibration values in each measuring mode, in which a scan speed is used as a parameter, of a MS analysis not involving the dissociation operation in the collision cell and of a MS/MS analysis involving the dissociation operation; anda control unit, reading, from the calibration information memory unit, mass calibration information corresponding to an ...

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Номер записи: 43
26-12-2013 дата публикации

AUGER ELEMENTAL IDENTIFICATION ALGORITHM

Номер: US20130341504A1
Автор: NASSER-GHODSI Mehran, Neill Mark, Sears Christopher
Принадлежит: KLA -TENCOR CORPORATION,

System and methods for decomposing an Auger electron spectrum into elemental and chemical components, includes conditioning and input spectrum to generate a normalized input spectrum; determining statistical correlation between the normalized input spectrum and stored elemental spectral signatures; and characterizing elemental or chemical species in the input spectrum from the statistical correlation, wherein said conditioning the input spectrum includes estimating a background signal of non-Auger electrons in the input spectrum and subtracting the estimated background signal from the input spectrum. 1. A method of Auger spectral analysis of an input spectrum , the input spectrum including an Auger spectrum , the method comprising:conditioning the input spectrum to generate a normalized input spectrum;determining a statistical correlation between the normalized input spectrum and one or more stored elemental spectral signatures; andcharacterizing species in the input spectrum from the statistical correlation,wherein said conditioning the input spectrum includes estimating a background signal of non-Auger electrons in the input spectrum and subtracting the estimated background signal from the input spectrum.2. The method of claim 1 , wherein the estimated background signal is a convex envelope of the input spectrum and said estimating the background signal include using a convex hull algorithm to calculate the convex envelope.3. The method of claim 1 , wherein said determining statistical correlation includes performing multilinear regression on the normalized input spectrum against the stored elemental spectral signatures.4. The method of claim 1 , wherein said conditioning the input spectrum further includes filtering the input spectrum to remove noise from the input spectrum.5. The method of claim 4 , wherein said filtering the input spectrum includes applying a Savitzky-Golay smoothing filter to the input spectrum.6. The method of claim 4 , wherein said filtering ...

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Номер записи: 44
02-01-2014 дата публикации

MICRO-REFLECTRON FOR TIME-OF-FLIGHT MASS SPECTROMETER

Номер: US20140001353A1
Автор: DANEL Jean-Sebastien, DURAFFOURG Laurent, PROGENT Frederic, TASSETTI Charles-Marie
Принадлежит: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (Former name: COMMISSARIAT A L'ENERGI

A micro-reflectron for a time-of-flight mass spectrometer including a substrate and integrated with the volume of the substrate, means for application of a potential gradient in a volume suitable for constituting a flight zone of the ions. The means of application includes at least two polarization electrodes and a wall of at least one resistive material that can be polarized between these electrodes so as to generate a continuous potential gradient, itself providing the function of reflectron, this flight zone, these electrodes and this wall being obtained by the technology of microelectromechanical systems (MEMS) and this micro-reflectron having a thickness of less than 5 millimetres while its other dimensions are less than 10 times this thickness. 1. A micro-reflectron for a time-of-flight mass spectrometer , the micro-reflectron comprising:a substrate and, integrated within an inner volume of the substrate, at least two polarization electrodes and a wall of at least one resistive material,wherein the substrate comprises two bonded wafers, at least one of the wafers having an etched channel therein, such that the bonded wafers define a tube enclosed by the wall, the tube comprising a flight zone for ions, andwherein the wall is polarized between the at least two polarization electrodes and generates a continuous potential gradient, the at least two polarization electrodes providing the continuous potential gradient for a reflectron and the flight zone, the at least two polarization electrodes and the wall being obtained by microelectromechanical systems (MEMS) technology comprising etching, deposition, and assembly and the micro-reflectron having a thickness in a thickness direction of less than 5 millimetres, and two characteristic lateral dimensions orthogonal to the thickness direction of less than 10 times the thickness.2. The micro-reflectron according to claim 1 , wherein the wall comprises at least one layer of resistive material on an inner surface of the ...

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Номер записи: 45
02-01-2014 дата публикации

Charged Particle Ray Apparatus and Pattern Measurement Method

Номер: US20140001360A1
Автор: Kasai Yuji, Makino Hiroshi, SUZUKI Makoto
Принадлежит: Hitachi-High-Technologies Corporation

Provided is a technique to automatize a synthesis function of signal charged particles having different energies. A charged particle beam apparatus includes: a charged particle source configured to irradiate a sample with a primary charged particle ray; a first detector configured to detect a first signal electron having first energy from signal charged particles generated from the sample; a second detector configured to detect a second signal electron having second energy from signal charged particles generated from the sample; a first operation part configured to change a synthesis ratio of a signal intensity of the first signal electron and a signal intensity of the second signal electron and to generate a detected image corresponding to each synthesis ratio; a second operation part configured to calculate a ratio of signal intensities corresponding to predetermined two areas of the detected image generated for each synthesis ratio; and a third operation part configured to determine a mixture ratio to be used for acquisition of the detected image on a basis of a change of the ratio of signal intensities. 1. A charged particle beam apparatus , comprising:a charged particle source configured to irradiate a sample with a primary charged particle beam;a first detector configured to detect a first signal electron having first energy from signal charged particles generated from the sample;a second detector configured to detect a second signal electron having second energy from signal charged particles generated from the sample;a first operation part configured to change a synthesis ratio of a signal intensity of the first signal electron and a signal intensity of the second signal electron and to generate a detected image corresponding to each synthesis ratio;a second operation part configured to calculate a ratio of signal intensities corresponding to predetermined two areas of the detected image generated for each synthesis ratio; anda third operation part configured ...

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Номер записи: 46
09-01-2014 дата публикации

EJECTION OF ION CLOUDS FROM 3D RF ION TRAPS

Номер: US20140008533A1
Автор: Brekenfeld Andreas, Gebhardt Christoph, HARTMER Ralf
Принадлежит:

The invention proposes a method for the collective ejection of ions from a 3D RF ion trap with a ring electrode and two end cap electrodes, which comprises the following steps: (a) the RF voltage of a high-quality resonant circuit applied to the ring electrode is replaced with a second RF voltage at the two end cap electrodes which can be changed or switched faster than the high voltage at the ring electrode, keeping the ions stored, (b) the second RF voltage at the end cap electrodes is then switched down or off abruptly, releasing the ions, and (c) the released ions are ejected through an opening in one of the end cap electrodes by switching on a DC voltage on at least one of the end cap electrodes. 1. A method for a collective ejection of ions from a 3D RF ion trap having a ring electrode and two end cap electrodes , comprising the steps:a) initially storing the ions by an RF voltage at the ring electrode,b) replacing the RF voltage at the ring electrode with a more rapidly switchable RF voltage at the two end cap electrodes to keep the ions stored,c) switching down abruptly the RF voltage at the end cap electrodes, andd) applying a DC voltage to at least one of the end cap electrodes to eject the ions through an opening in one of the end cap electrodes.2. The method according to claim 1 , wherein the two RF voltages have the same frequency but phases of opposite polarity; and in Step b) claim 1 , the amplitudes of the two RF voltages are increased and decreased in the contrary direction claim 1 , respectively.3. The method according to claim 1 , wherein the two RF voltages have different frequencies.4. The method according to claim 3 , wherein a value of one of the frequencies corresponds to an integer fraction of a frequency of the other RF voltage.5. The method according to claim 4 , wherein the two frequencies are coupled in phase-locked relationship.6. The method according to claim 3 , wherein in Step b) the amplitudes of the RF voltages are decreased and ...

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Номер записи: 47
06-02-2014 дата публикации

Adjusting energy of ions ejected from ion trap

Номер: US20140034825A1
Автор: Kenneth Newton
Принадлежит: AGILENT TECHNOLOGIES INC

An ion trap includes a trap exit at which an ion energy adjusting device is located. The adjusting device may be configured for focusing a beam of ions ejected from the trap, reducing the energy distribution of the ions, and/or reducing the average kinetic energy of the ions. The adjusting device may include lenses to which RF and/or DC voltages are applied.

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Номер записи: 48
06-02-2014 дата публикации

Systems and methods for ms-ms-analysis

Номер: US20140034827A1
Автор: Alexander Mordehai, Kenneth R. Newton
Принадлежит: AGILENT TECHNOLOGIES INC

A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.

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Номер записи: 49
13-02-2014 дата публикации

M/Z Targeted Attenuation on Time of Flight Instruments

Номер: US20140042312A1
Автор: Richardson Keith
Принадлежит: MICROMASS UK LIMITED

A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity. 1. A method of mass spectrometry comprising:separating ions according to one or more physico-chemical properties;providing a Time of Flight mass analyser; andcontrolling ions which are onwardly transmitted to said Time of Flight mass analyser by attenuating first ions having a first physico-chemical property within one or more first ranges which would otherwise be transmitted to said Time of Flight mass analyser and which have been determined to have or which are predicted to have a relatively high intensity.2. A method as claimed in claim 1 , wherein said step of controlling ions which are onwardly transmitted to said Time of Flight mass analyser further comprises attenuating first ions having a second physico-chemical property within one or more second ranges.3. A method as claimed in or claim 1 , wherein a two dimensional or multidimensional separation is performed wherein ions are simultaneously separated according to two different physico-chemical properties and wherein first ions which are attenuated have both a first physico-chemical property within one or more first ranges and a second physico-chemical property within one or more second ranges.4. A method as claimed in or claim 1 , wherein a plurality of one dimensional or single dimensional separations are performed in series or sequentially wherein ions are initially separated according to a first physico-chemical property and wherein first ions which are attenuated have a first physico-chemical property within one or more first ranges and wherein said ions are then subsequently ...

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Номер записи: 50
13-02-2014 дата публикации

Electron Transfer Dissociation Device

Номер: US20140042314A1
Автор: Jeffery Mark Brown, Martin Raymond Green
Принадлежит: Micromass UK Ltd

A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.

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Номер записи: 51
13-02-2014 дата публикации

COMPACT ION MOBILITY SPECTROMETER

Номер: US20140042315A1
Автор: Baykut Gokhan
Принадлежит:

The invention relates to devices for measuring the mobility of ions in gases at pressures of a few hectopascal. To make the device more compact, drift regions are bent into curved shapes, which extend into the third dimension. Parts of the drift region may lie above others. Alternating directions of curvature in the curved shapes balance out different path lengths by passing through approximately equal drift distances on outer and inner trajectories. Ions are held near the axis of the curved drift region by sectional or permanent focusing. One possible shape is a double loop in the shape of a figure eight. The shape extends perpendicular to its plane of projection so that several double loops lie on top of each other. RF ion funnels or ion tunnels can keep the ions near the axis. Axial focusing may use a pseudopotential radial to the axis of the curved shape. 1. Device for the separation of ions according to their ion mobility with a drift region in which the ions are pulled through a gas by means of electric fields , wherein the drift region is bent into a curved shape which extends over three spatial dimensions and comprises opposing curvatures such that ions at a distance from the axis travel alternately on outer and inner trajectories.2. Device according to claim 1 , wherein the curved shape of the drift region turns back on itself in the projection onto a base area claim 1 , and at least parts of the drift region come to lie adjacent to each other in a third dimension.3. Device according to claim 2 , wherein the drift region is designed as a tube with inner electrodes and gas flows in the tube.4. Device according to claim 2 , wherein the drift region has the shape of a figure eight layered in tiers.5. Device according to claim 1 , wherein the drift region is formed by a row of apertured diaphragms.6. Device according to with a voltage supply which is used to supply the apertured diaphragms alternately with the two phases of an RF voltage.7. Device according to ...

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Номер записи: 52
20-02-2014 дата публикации

Pre-Scan For Mass to Charge Ratio Range

Номер: US20140048701A1
Автор: Green Martin Raymond, Wildgoose Jason Lee
Принадлежит: MICROMASS UK LIMITED

A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters. 1. A method of mass spectrometry comprising:performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during said first analysis;automatically determining one or more ranges of interest of said one or more parameters from said first analysis; andautomatically performing a second subsequent analysis of said sample of ions, wherein said second analysis is restricted to one or more of said ranges of interest of said one or more parameters.2. A method as claimed in claim 1 , wherein said first analysis and said second analysis are performed using the same first analytical device.3. A method as claimed in claim 2 , wherein said first analytical device is operated at a first resolution to perform said first analysis and is then operated at a second higher resolution to perform said second analysis.4. A method as claimed in claim 1 , wherein said first analysis is performed using a first analytical device and said second analysis is performed using a second different analytical device.5. A method as claimed in claim 4 , wherein said first analytical device is operated at a first resolution to perform said first analysis and said second analytical device is operated at a second higher resolution to perform said second analysis.6. A method as claimed in any preceding claim claim 4 , wherein said parameter comprises the mass or mass to charge ...

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Номер записи: 53
20-02-2014 дата публикации

Mass Spectrometer

Номер: US20140048704A1
Автор: Bateman Robert Harold, Giles Kevin, Pringle Steven Derek, Wildgoose Jason Lee
Принадлежит: MICROMASS UK LIMITED

A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. 1. A mass spectrometer comprising:an ion mobility separator;an ion guide comprising a stack of electrodes arranged downstream of said ion mobility separator;a voltage source for applying one or more voltages to the stack of electrodes for generating an axial potential;a mass filter or a further ion guide;a fragmentation or collision cell; anda TOF mass analyser orthogonally disposed downstream of the ion guide.2. A mass spectrometer as claimed in claim 1 , wherein said mass filter comprises a quadrupole mass filter.3. A mass spectrometer as claimed in claim 1 , wherein said mass filter is arranged so that a mass filtering characteristic of said mass filter is progressively varied claim 1 , increased or stepped.4. A mass spectrometer as claimed in claim 3 , wherein said mass filter is arranged so that ions having a first charge state are onwardly transmitted whereas ions having a second different charge state are substantially attenuated by said mass filter.5. A mass spectrometer as claimed in claim 4 , wherein said mass filter is arranged so that multiply charged ions are preferentially selected and are onwardly transmitted by said mass filter.6. A mass spectrometer as claimed in claim 5 , wherein said mass filter is arranged so that singly charged ions are reduced or substantially attenuated by said mass filter.7. A mass spectrometer as claimed in claim 1 , wherein said mass filter is operated as a high pass mass to ...

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Номер записи: 54
27-02-2014 дата публикации

Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers

Номер: US20140054454A1
Автор: Hoyes John Brian, Langridge David J., Wildgoose Jason
Принадлежит: MICROMASS UK LIMITED

A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector. 1. A Time of Flight mass analyser comprising:one or more devices arranged and adapted to correct for tilt in one or more isochronous planes of ions.2. A Time of Flight mass analyser as claimed in claim 1 , further comprising an ion detector.3. A Time of Flight mass analyser as claimed in or claim 1 , wherein said Time of Flight mass analyser comprises an axial acceleration Time of Flight mass analyser.4. A Time of Flight mass analyser as claimed in or claim 1 , wherein said Time of Flight mass analyser comprises an orthogonal acceleration Time of Flight mass analyser.5. A Time of Flight mass analyser as claimed in claim 4 , further comprising an orthogonal acceleration region.6. A Time of Flight mass analyser as claimed in claim 5 , wherein said orthogonal acceleration region comprises a pusher or puller electrode and/or a first grid or other electrode and/or a second grid or other electrode.7. A Time of Flight mass analyser as claimed in claim 6 , further comprising a first field free region between said pusher or puller electrode and said first grid or other electrode.8. A Time of Flight mass analyser as claimed in or claim 6 , further comprising a second field free region between said first grid or other electrode and said second grid or other electrode.98. A Time of Flight mass analyser as claimed in any of - claims 5 , further comprising a third field free region located either: (i) between said orthogonal acceleration region and said ion detector; or (ii) between said second grid or other electrode and said ion detector.109. A Time of Flight mass analyser as claimed in any of - claims 2 , wherein said one or more devices are arranged and adapted to correct for tilt in an isochronous plane of ions ...

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Номер записи: 55
27-02-2014 дата публикации

ZERO DEAD TIME, HIGH EVENT RATE, MULTI-STOP TIME-TO-DIGITAL CONVERTER

Номер: US20140054455A1
Автор: DUMONTHIER JEFFREY J., SUAREZ GEORGE
Принадлежит:

Time-to-digital converters adapted to analog and digital inputs and methods of use are described. A time-to-digital converter has an event frame latches and logic module with memory cells, an analog front-end module connected to the memory cells, and a bin increment generator module connected to the memory cells. The bin increment generator is configured to issue bin increments separated by a time increment, and the analog front end is configured to issue a start event followed by a plurality of stop events. Upon receipt of a first time increment following a start event, the event frame latches and logic module updates a first memory cell with a first bit-type; upon receipt of a second time increment following an intervening stop event, the event frame latches and logic module updates a second memory cell with a second bit-type different from the first bit-type. 1. A time-to-digital converter , comprising:an event frame latches and logic module having a plurality of memory cells;an analog front-end module connected to the event frame module; anda bin increment generator module connected to the event frame latches and logic module,wherein the bin increment generator module is configured to issue a sequence of bin increments to the event frame latches and logic module and wherein a successive bin increment follows a predecessor bin increment by a time interval,wherein the analog front-end module is configured to issue an event start indication to the event frame latches and logic module,wherein the analog front-end module is configured to issue at least one event stop indication to the event frame latches and logic module,wherein the event frame latches and logic module is configured to update at least one memory cell when the analog front-end module issues a bin increment, andwherein the memory cell update comprises a first bit-type following the issue of the start event indication, and wherein the memory cell update comprises a second bit-type following the issue of ...

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Номер записи: 56
27-02-2014 дата публикации

TIME-OF-FLIGHT MASS SPECTROMETER

Номер: US20140054456A1
Автор: FURUHASHI Osamu, KINUGAWA Tohru
Принадлежит:

An embodiment with a dual-stage reflectron is as follows: (1) On the assumption that a reflector has a base potential X(U) created by uniform electric fields, its design parameters are adjusted so as to cancel the first and second order derivatives at energy E=Eof a total time of flight T(E), and a second-order focusing position on a central axis at which the potential value becomes zero is determined (Mamyrin solution). (2) A correcting potential X(U) to be superposed on X(U), beginning from the second-order focusing position, is calculated so that T(E) of ions reflected in a region deeper than the second-order focusing position will be constant. (3) Voltage values of the reflector electrodes are determined so that a real potential X(U)=X(U)+X(U) is created on the central axis. 1. A time-of-flight mass spectrometer including an ion ejector for accelerating target ions by imparting a certain amount of energy to the ions , an ion reflector for reflecting ions ejected from the ion ejector and turning the ions around by an effect of an electric field , an ion detector for detecting the ions reflected by and exiting from the ion reflector , and a reflector driver for driving the ion reflector so as to create a reflecting electric field inside the ion reflector , wherein:{'sub': A', 'A', '0', '0, 'with X denoting a coordinate along a central axis of the ion reflector, the reflector driver applies a voltage to the ion reflector so as to create, inside an inner hollow area of the ion reflector and along the central axis of the ion reflector, a predetermined potential distribution U(X) in which the potential monotonously changes over the entire ion reflector and therefore an inverse function X(U) can be uniquely obtained, thus creating an N-th order focusing position at a position with coordinate Xand potential Einside the ion reflector; and'}{'sub': 0', 'A', 'C', '0', '0', '0, 'sup': 'N+3/2', 'the reflector driver also applies a voltage to the ion reflector within a space ...

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Номер записи: 57
06-03-2014 дата публикации

FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY SYSTEM

Номер: US20140061459A1
Автор: Allsworth Max, Hart Alison, Hart Matthew, Hartwell Stephen, Jamieson Lara, Somerville John, Wilks Ashley
Принадлежит: OWLSTONE NANOTECH INC

An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow. 1. An apparatus for detecting , identifying , classifying and/or quantifying chemical species in a gas flow comprising:a micro-fabricated ion filter;a system adapted to apply drive signals to the ion filter;a system adapted to measure the output of the ion filter; anda system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.2. An apparatus as recited in wherein the ion filter separates ions using a Field Asymmetric Waveform Ion Mobility Spectrometer (FAIMS).3. An apparatus as recited in further adapted to use measurements of ion current as a function of one or more of compensation field and dispersion field to facilitate chemical detection claim 2 , identification claim 2 , classification and/or quantification.4. An apparatus as recited in further adapted to use the trajectory of one or more ion peaks in FAIMS spectrum to facilitate chemical detection claim 3 , identification claim 3 , classification and/or quantification.5. An apparatus as recited in further adapted to classify ion peak trajectories into one or more of a number of categories to facilitate chemical detection claim 4 , identification claim 4 , classification and/or quantification.6. An apparatus as recited in wherein the categories are based on the form of variation in the peak position along the compensation field axis as dispersion ...

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Номер записи: 58
13-03-2014 дата публикации

ION ANALYSIS APPARATUS AND METHOD

Номер: US20140070087A1
Автор: GILES Roger, Gill Matthew Clive
Принадлежит:

The present invention is concerned with an ion analysis apparatus comprising an ion guide having an ion optical axis extending from an ion inlet to an ion outlet, the ion guide being configured to guide ions from the ion inlet to the ion outlet along the ion optical axis, wherein the ion guide comprises at least one extraction region located between the ion inlet and the ion outlet, the at least one extraction region being configured to extract ions moving along the ion optical axis of the ion guide in an extraction direction, the extraction direction being substantially orthogonal to the ion optical axis of the ion guide, wherein the apparatus includes ion radial confinement means that in use confine the ions in the radial direction within the ion guide. 1. An ion analysis apparatus comprising an ion guide having an ion optical axis extending from an ion inlet to an ion outlet , the ion guide being configured to guide ions from the ion inlet to the ion outlet along the ion optical axis , wherein the ion guide comprises at least one extraction region located between the ion inlet and the ion outlet , the at least one extraction region being configured to extract ions moving along the ion optical axis of the ion guide in an extraction direction , the extraction direction being substantially orthogonal to the ion optical axis of the ion guide , wherein the apparatus includes an ion radial confinement device that in use confines the ions in the radial direction within the ion guide , said ion radial confinement device comprising a first ion radial confinement device associated with a portion of the ion guide located before the extraction region and a second ion radial confinement device associated with the at least one extraction region , and wherein the extraction region is switchable between an extraction mode and a transmission mode.2. An ion analysis apparatus according to claim 1 , wherein the ion guide is a linear ion guide and the ion optical axis is the ...

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Номер записи: 59
13-03-2014 дата публикации

Elemental flow cytometer

Номер: US20140070092A1
Автор: Dmitry R. Bandura, Scott D. Tanner, Vladimir I. Baranov
Принадлежит: PerkinElmer Health Sciences Inc

An elemental flow cytometer includes a device to vaporize, atomize, and ionize material and an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets. A spectrometer is adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets.

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Номер записи: 60
27-03-2014 дата публикации

Nanoparticulate Assisted Nanoscale Molecular Imaging by Mass Spectrometery

Номер: US20140084153A1
Автор: Egan Thomas F., Lewis Ernest K., Schultz J. Albert, Ulrich Steven, Waters Kelley L.
Принадлежит: IONWERKS, INC.

Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source. 1. An analytical instrument for the characterization and analysis of a sample comprising:a sample stage for positioning a sample;a nanoparticulate beam source positioned to deliver a nanoparticulate beam to a sample on said sample stage;a nanofocused primary particle beam source or a nanofocused photon beam source, or both, said beam source positioned to deliver a beam to said sample; and,an analyzer positioned to analyze material or photons emitted from said sample.2. The instrument of claim 1 , wherein said sample stage is an XY sample stage.3. The instrument of claim 1 , comprising a component selected from the group consisting of a cluster beam source claim 1 , a vapor deposition system claim 1 , a laser ablation system claim 1 , an electrospray ionization source claim 1 , a molecular beam source claim 1 , an atomic layer epitaxy source claim 1 , an ion beam deposition source claim 1 , a Knudsen effusion cell claim 1 , a magnetron sputter source claim 1 , an electron beam evaporator source claim 1 , an atomic hydrogen claim 1 , oxygen or nitrogen source claim 1 , an ozonolysis source claim 1 , a plasma etching source claim 1 , an aerosol generator source claim 1 , and any combination thereof claim 1 , said component being position to deliver material to said sample claim 1 , to said nanoparticulate beam or to both.4. The instrument of claim 1 , wherein the analyzer comprises a mass spectrometer.5. The instrument of claim 4 , wherein the mass spectrometer is a time-of-flight mass spectrometer.6. The instrument of claim 1 , wherein the analyzer comprises a fluorescence spectrometer.7. The instrument of claim 1 , wherein the nanofocused primary particle beam ...

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Номер записи: 61
27-03-2014 дата публикации

Ion Mobility Spectrometer Which Controls Carrier Gas Flow to Improve Detection

Номер: US20140087477A1
Автор: Stephen John Taylor
Принадлежит: Smiths Detection Watford Ltd

IMS apparatus has an inlet with a preconcentrator opening into a reaction region where analyte molecules are ionized and passed via a shutter to a drift region for collection and analysis. A pump and filter arrangement supplies a flushing flow of clean gas to the housing in opposition to ion flow. A pressure pulser connects with the housing and is momentarily switched to cause a short drop in pressure, in the housing to draw in a bolus of analyte sample from the preconcentrator. Just prior to admitting a bolus of sample, the pump is turned off so that the flushing flow drops substantially to zero, thereby prolonging the time the analyte molecules spend in the reaction region.

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Номер записи: 62
10-04-2014 дата публикации

MCP UNIT, MCP DETECTOR, AND TIME-OF-FLIGHT MASS SPECTROMETER

Номер: US20140097339A1
Автор: SUZUKI Akio, WASHIYAMA Yuuya
Принадлежит: HAMAMATSU PHOTONICS K.K.

An MCP unit of the present invention has a triode structure with a structure to achieve a desired time response characteristic independent of restrictions from a channel diameter of MCP, and is provided with an MCP group, a first electrode, a second electrode, an anode, and an acceleration electrode. Particularly, the MCP unit further comprises a ring member between the acceleration electrode and the anode, as s restriction structure for confining reflected electrons emitted from the anode in response to incidence of secondary electrons from the MCP group, within a space between the acceleration electrode and the anode. 1. An MCP unit comprising:a microchannel plate arranged on a plane intersecting with a central axis of the MCP unit and configured to emit secondary electrons internally multiplied in response to incidence of a charged particle traveling along the central axis, the microchannel plate having an entrance face which the charged particle enters, and an exit face which is opposed to the entrance face and which the secondary electrons exit;a first electrode in contact with the entrance face of the microchannel plate, the first electrode being set at a first potential;a second electrode in contact with the exit face of the microchannel plate, the second electrode being set at a second potential higher than the first potential;an anode arranged as intersecting with the central axis, at a position where the secondary electrons emitted from the exit face of the microchannel plate arrive, the anode being set at a third potential higher than the second potential;an acceleration electrode arranged between the microchannel plate and the anode, the acceleration electrode being set at a fourth potential higher than the second potential and having a plurality of openings for allowing the secondary electrons traveling from the exit face of the microchannel plate to the anode to pass therethrough; anda ring member arranged between the acceleration electrode and the ...

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Номер записи: 63
07-01-2016 дата публикации

Optimised Ion Mobility Separation Timescales for Targeted Ions

Номер: US20160003773A1
Автор: Giles Kevin, Pringle Steven Derek, Wildgoose Jason Lee
Принадлежит:

An analytical device for analysing ions is provided comprising a separator for separating ions according to a physico-chemical property and an interface comprising one or more ion guides. A quadrupole rod set mass filter is arranged downstream of the interface. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator through the interface with a first transit time t; and (ii) to transmit a second group of ions which subsequently emerges from the separator through the interface with a second different transit time t 1. An analytical device for analysing ions comprising:a separator for separating ions according to a physico-chemical property;an interface comprising one or more ion guides, each ion guide comprising a plurality of electrodes;a quadrupole rod set mass or mass to charge ratio filter arranged downstream of said interface; anda control system arranged and adapted:{'b': '1', '(i) to transmit a first group of ions which emerges from said separator through said interface with a first transit time t; and'}{'b': '2', '(ii) to transmit a second group of ions which subsequently emerges from said separator through said interface with a second different transit time t.'}2. An analytical device as claimed in claim 1 , wherein said physico-chemical property comprises ion mobility or differential ion mobility.3. An analytical device as claimed in claim 2 , wherein said separator comprises an ion mobility separator or a differential ion mobility separator.4. An analytical device as claimed in claim 1 , wherein said physico-chemical property comprises mass or mass to charge ratio.5. An analytical device as claimed in claim 4 , wherein said separator comprises a time of flight region.6221. An analytical device as claimed in claim 1 , wherein said control system is arranged and adapted to transmit said second group of ions through said interface with a transit time t claim 1 , wherein t>t.7. An analytical device as ...

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Номер записи: 64
07-01-2016 дата публикации

Substances Detection System and Method

Номер: US20160003774A1
Автор: Crnatovic Aleksandar, Nacson Sabatino, Wiseman George
Принадлежит: TEKNOSCAN SYSTEMS INC.

A system and methodology for the detection of threat substances is described. The detector system consists of a method to evaporate the sample into a primary separator and thermal release of trapped target materials into a secondary separator like conventional GC. The GC column is thermally ramped to elute all substances and the end of the column terminates into an atmospheric pressure chemical ionization source of an axial ion mobility spectrometer (AIMS). Both polarity ions are pulsed into a single construction separator tube at different timing. Their arrival time is detected on a collector plate, which allows registering their ion mobility spectra of both polarities for a single GC peak. 19.-. (canceled)10. An apparatus for detecting the presence of one or more predetermined analytes in a sample , wherein the predetermined analytes number two or more , the apparatus comprising:a detector configured to receive and detect the presence of predetermined analytes carried in a carrier gas;a carrier gas generator, the generator comprising a single reservoir and configured to selectively operate in a gas delivery mode in which clean carrier gas is delivered to the detector and a cleaning mode in which the generator generates clean carrier gas for subsequent use in the detector;wherein the detector and the generator and positioned in a common housing.11. An apparatus for detecting the presence of one or more predetermined analytes in a sample , wherein the predetermined analytes number two or more , the apparatus comprising:a detector configured to receive and detect the presence of predetermined analytes carried in a carrier gas;a carrier gas generator, the generator comprising first and second reservoirs and configured such that the first reservoir operates in a gas delivery mode in which clean carrier gas is delivered to the detector while the second operates in a cleaning mode in which clean carrier gas is generated for subsequent use in the detector;the generator ...

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Номер записи: 65
07-01-2016 дата публикации

Methods Of Detecting Cancer

Номер: US20160003786A1
Автор: Anna Daily, Lindsay Rutherford
Принадлежит: Ascendant Diagnostics Llc

The present disclosure is directed toward methods and kits for detecting cancer, and in particular breast cancer, in a subject by measuring the levels of at least one of the identified markers, as compared to a control. The expression of the markers in Table 2A is increased in samples from subjects with cancer as compared to the expression level in subjects without cancer and the expression of the markers in Table 2B are decreased in samples from subjects with cancer as compared to the expression level in subjects without cancer. The sample may be lacrimal secretions or eye wash fluid, saliva, or other biological fluids. The kits may include an eye wash kit, collection tubes and protease inhibitors, or protein stabilizers.

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Номер записи: 66
07-01-2016 дата публикации

Photo or chemolabile conjugates for molecules detection

Номер: US20160003836A1
Автор: Jean-Philippe Ebran, Jonathan Stauber, Oleg Melnyk
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, IMABIOTECH, Universite De Lille 1 Sciences Et Technologies

The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.

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Номер записи: 67
01-01-2015 дата публикации

REAGENTS FOR OXIDIZER-BASED CHEMICAL DETECTION

Номер: US20150004710A1
Автор: Gregory Kerin E., Kunz Roderick R., Sworin Michael
Принадлежит: Massachusetts Institute of Technology

Reagents and methods are disclosed for detection of oxidizers and inorganic salts and other analytes of interest. The reagents can interact with their target analytes, especially oxidizer compositions or oxidizer-based explosives, to selectively enhance their ionization yield, interacting by chemical reaction or by forming an associative adduct which facilitates their detection. For example, the reagents can adduct with the counter-ion of the intended analyte for improved direct detection and/or react chemically via acid-base reactions to produce a new product for detection. In another aspect of the invention, reactive reagents and methods are also disclosed that facilitate indirect detection of the analyte at lower temperatures based on reduction-oxidation (redox) chemistry. These reagents are particularly useful in detecting oxidizer analytes. 1. A method for detection of an analyte molecule , M , potentially present in a sample as an ionizable compound or complex , MX , capable of dissociating into constituent ionic species , Mand counter-ions X , the method comprising: {'sup': +', '−, 'X, as a compound or complex XA, thereby ensuring greater availability of the ionized analyte, M, for detection; and'}, 'introducing a reagent, A, to sequester at least some of the counter-ions'}subjecting the ionized components of the sample to mass spectrometry, whereby the presence of M in the sample can be deduced.2. The method of wherein the method further comprises step of volatizing MX if present in the sample and dissociating it into constituent ionic species claim 1 , Mand counter-ions X claim 1 , before claim 1 , during or after dissociation.3. The method of wherein the step of subjecting ionized components of the sample to mass spectrometry further comprises subjecting the ionized components to ion mobility spectrometry.4. The method of wherein the method further comprises associating the reagent with a swipe prior to sample collection and then using the swipe to obtain ...

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Номер записи: 68
07-01-2016 дата публикации

MULTI-REFLECTION MASS SPECTROMETER

Номер: US20160005580A1
Автор: GRINFELD Dmitry, Makarov Alexander
Принадлежит:

A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction and having a space therebetween, the X direction being orthogonal to Y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the X direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length. 1. (canceled)2. A multi-reflection mass spectrometer comprising two ion-optical mirrors , each mirror elongated generally along a drift direction (Y) , each mirror opposing the other in an X direction and having a space therebetween , the X direction being orthogonal to the Y direction;the spectrometer further comprising an ion injector located at one end of the ion-optical mirrors in the drift direction, arranged so that in use it injects ions such that they oscillate between the ion-optical mirrors, reflecting from one mirror to the other generally orthogonally to the drift direction a plurality of times, turning the ions within each mirror whilst the ions proceed along the drift direction Y;wherein a distance between subsequent points at which the ions turn in the Y-direction changes monotonously with Y during at least a part of the motion of the ions along the drift direction.3. The multi-reflection mass spectrometer of in which the mass spectrometer further comprises one or more compensation electrodes each electrode being located in or ...

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Номер записи: 69
07-01-2016 дата публикации

Ion Trap Mass Spectrometer

Номер: US20160005584A1
Автор: Verenchikov Anatoly N.
Принадлежит:

An electrostatic mass spectrometer and a method of mass spectrometric analysis utilizing novel traps are disclosed. The mass spectrometer includes an ion source, an ion pulse injector, an ion detector, a set of analyzer electrodes connected to a set of power supplies, and a vacuum chamber enclosing the set of analyzer electrodes. The analyzer electrodes have multiple sets of elongated slits forming an array of elongated volumes. Each elongated volume is formed by a single set of slits aligned between the electrodes, and each volume forms a two-dimensional electrostatic field in an X-Y plane and is extended in a locally orthogonal Z-direction. Each two-dimensional field is arranged to trap moving ions in the X-Y plane and to enable isochronous ion motion along a mean ion trajectory within the X-Y plane. 146.-. (canceled)47. An electrostatic mass spectrometer comprising:at least one ion source;means for ion pulsed injection, said means are in communication with said at least one ion source;at least one ion detector;a set of analyzer electrodes;a set of power supplies connected to said analyzer electrodes;a vacuum chamber enclosing said electrode set; andwithin said electrode set, multiple sets of elongated slits forming an array of elongated volumes;wherein each volume of said array being formed by a single set of slits aligned between said electrodes;wherein each volume forming a two-dimensional electrostatic field in an X-Y plane extended in a locally orthogonal Z-direction; andwherein each two-dimensional field being arranged for trapping of moving ions in said X-Y plane and isochronous ion motion along a mean ion trajectory lying in said X-Y plane.48. An apparatus as in claim 47 , wherein said field volumes are aligned as one of the group: (i) a stack of linear fields; (ii) a rotational array of linear fields; (iii) a single field region folded along a spiral claim 47 , stadium shape claim 47 , or a snake shape line; (iv) a coaxial array of torroidal fields; and ( ...

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Номер записи: 70
13-01-2022 дата публикации

ANALYSIS METHOD AND NON-TRANSITORY COMPUTER READABLE MEDIUM

Номер: US20220013344A1
Автор: KUDO Yukihiko, Sugimoto Shinji
Принадлежит: SHIMADZU CORPORATION

An analysis method includes analyzing a reference sample that contains a predetermined amount of a predetermined component by an analysis device using a chromatograph and obtaining a reference detection value which is a detection value of the predetermined amount of the predetermined component detected by the analysis device, calculating a judgment reference value which is a criterion for judging whether a concentration of a detection subject component in a measurement subject sample is equal to or larger than a reference concentration or equal to or smaller than the reference concentration based on the reference detection value, and analyzing the measurement subject sample by the analysis device and judging that the detection subject component has been detected in a case where a detection value exceeding the judgment reference value is detected in a peak detection time zone corresponding to the detection subject component. 1. An analysis method including:analyzing a reference sample that contains a predetermined amount of a predetermined component by an analysis device using a chromatograph and obtaining a reference detection value which is a detection value of the predetermined amount of the predetermined component detected by the analysis device;calculating a judgment reference value which is a criterion for judging whether a concentration of a detection subject component in a measurement subject sample is equal to or larger than a reference concentration or equal to or smaller than the reference concentration based on the reference detection value; andanalyzing the measurement subject sample by the analysis device and judging that the detection subject component has been detected in a case where a detection value exceeding the judgment reference value is detected in a peak detection time zone corresponding to the detection subject component.2. The analysis method according to claim 1 , whereindetection of the detection subject component or non-detection of the ...

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Номер записи: 71
07-01-2016 дата публикации

DIFFERENTIALLY PUMPED DUAL LINEAR QUADRUPOLE ION TRAP MASS SPECTROMETER

Номер: US20160005586A1
Автор: Kenttamaa Hilkka I., Owen Benjamin C.
Принадлежит:

The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers. 120-. (canceled)21. A system comprising:a first mass spectrometer comprising a first ion trap in a first vacuum chamber;a second mass spectrometer comprising a second ion trap in a second vacuum chamber; anda vacuum manifold operably connecting the first and second vacuum chambers such that charged particles travel from the first vacuum chamber into the second vacuum chamber.22. The system according to claim 21 , wherein the vacuum manifold contacts the first mass spectrometer at a back portion and contacts the second mass spectrometer at a front portion.23. The system according to claim 22 , wherein the second ion trap is a linear quadrupole ion trap.24. The system according to claim 23 , wherein the first ion trap is a linear quadrupole ion trap.25. The system according to claim 21 , wherein the vacuum manifold comprises a multipole.26. The system according to claim 25 , wherein the multipole in the vacuum chamber is configured to allow ions to travel from the first mass spectrometer to the second mass spectrometer.27. The system according to claim 21 , further comprising an ionization source operably associated with the first mass spectrometer.28. The system according to claim 27 , wherein the ionization source is an atmospheric pressure ionization source.29. The system according to claim 24 , further comprising:a first multipole and a first lens operably associated with the first ion trap; anda second multipole and a second lens operably associated with the second ion trap.30. The system according to claim 29 , further comprising an ion introduction multipole positioned between the ionization source and the first multipole. ...

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Номер записи: 72
07-01-2016 дата публикации

Ion Trap Mass Spectrometer

Номер: US20160005587A1
Автор: Verenchikov Anatoly N.
Принадлежит:

An electrostatic analyzer including at least one first set of electrodes, at least one second set of electrodes, and a field free space separating the two sets of electrodes is disclosed. The two sets of electrodes form two-dimensional electrostatic fields of ion mirrors and are arranged to provide isochronous ion oscillations in an x-y plane. Both sets of electrodes are curves at a constant curvature radius R along a third locally orthogonal Z-direction to form a torroidal field region. A related method is also disclosed. 126-. (canceled)27. An electrostatic analyzer comprising:at least one first set of electrodes forming a two-dimensional electrostatic field of an ion mirror in an X-Y plane; said ion mirror arranged to provide ion reflections in an X-direction;at least one second set of electrodes forming a two-dimensional electrostatic field in said X-Y plane; anda field free space separating said two electrode sets;wherein said two electrode sets are arranged to provide isochronous ion oscillations in said; field free space,wherein both of said two electrode sets are curved at constant curvature radius R along a third locally orthogonal Z-direction to form at least one torroidal field regions.28. The electrostatic analyzer of claim 27 , wherein at least one of said electrode sets is angularly modulated to periodically reproduce three-dimensional field sections E(X claim 27 ,Y claim 27 ,Z) along the third locally orthogonal Z-direction.29. The electrostatic analyzer of claim 27 , wherein within said first set of mirror electrodes claim 27 , at least one outer ring electrode is connected to a higher repelling voltage relative to an opposite electrode of an internal ring.30. The electrostatic analyzer of claim 27 , wherein said torroidal field regions comprise sections with different curvature radii to form one shape of the group: (i) a spiral; (ii) a snake-shape; and (iii) a stadium-shape.31. The electrostatic analyzer of claim 27 , wherein the angle between the ...

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Номер записи: 73
03-01-2019 дата публикации

INTELLIGENTLY CONTROLLED SPECTROMETER METHODS AND APPARATUS

Номер: US20190006160A1
Автор: Osgood Mark A, Wu Ching
Принадлежит: Excellims Corporation

The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. 1. A vacuum inlet for a mass spectrometer comprising , a mechanism that controls a vacuum inlet structure for the mass spectrometera) to maintain the mass spectrometer at a pressure by dynamically controlling the size of the vacuum inlet at a first state; andb) to pulse the inlet structure according to a timing diagram to allow some part of a sample to enter the mass spectrometer, by temporarily changing the inlet structure to a second state;wherein each of the inlet structure states involves opening or closing the vacuum inlet to a particular size.2. The apparatus in claim 1 , further comprises an ion mobility spectrometer that is outside the vacuum inlet structure.3. The apparatus in claim 2 , wherein the timing diagram is generated by the ion mobility spectrometer.4. The apparatus of claim 1 , wherein the mechanism that controls a vacuum inlet structure includes driving component(s) that are used for maintaining the pressure and/or for pulsing to allow samples to enter the mass spectrometer.5. The apparatus of claim 4 , wherein the driving component(s) are selected from: magnetic actuator claim 4 , piezoelectric actuator claim 4 , mechanical actuator.6. The apparatus of claim 1 , wherein dynamically controlling the size of the vacuum inlet is performed by deforming a conductive elastomer.7. The apparatus of claim 6 , wherein the conductive elastomer is deformed by compressing claim 6 , expanding claim 6 , rotating and/or ...

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Номер записи: 74
03-01-2019 дата публикации

Mass Spectrometer

Номер: US20190006164A1
Автор: Terui Yasushi, YOSHINARI Kiyomi
Принадлежит:

Acceleration of decelerated ions and a reduction in the velocity dispersion width of decelerated ions are both achieved, whereby the sensitivity of detected ion sensitivity is improved and resolution is improved. The distance dx between at least one set of facing rod-shaped electrodes among rod-shaped electrodes (--) to (--) differs at the inlet part at which ions enter and the outlet part at which ions exit, and the distance dx between the at least one set of facing rod-shaped electrodes is gradually reduced or increased from the inlet part toward the outlet part. 1. A mass spectrometer , comprising:2n rod-like electrodes; and{'sub': 'RF', 'a control unit configured to apply a DC voltage U and a radio frequency voltage Vcos Ωt to the rod-like electrodes to generate a high-frequency multipole electric field equal to or more than a quadrupole electric field between the rod-like electrodes, whereina distance between at least a pair of facing rod-like electrodes of the rod-like electrodes at an entrance portion that ions enter is different from the distance at an exit portion from which ions are emitted; andthe distance between the at least pair of the facing rod-like electrodes is gradually reduced from the entrance portion toward the exit portion.2. A mass spectrometer , comprising:2n rod-like electrodes; and{'sub': 'RF', 'a control unit configured to apply a DC voltage U and a radio frequency voltage Vcos Ωt to the rod-like electrodes to generate a high-frequency multipole electric field equal to or more than a quadrupole electric field between the rod-like electrodes, whereina distance between at least a pair of facing rod-like electrodes of the rod-like electrodes at an entrance portion that ions enter is different from the distance at an exit portion from which ions are emitted; andthe distance between the at least pair of the facing rod-like electrodes is gradually increased from the entrance portion toward the exit portion.3. The mass spectrometer according to ...

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Номер записи: 75
03-01-2019 дата публикации

TIME-OF-FLIGHT MASS SPECTROMETER

Номер: US20190006168A1
Автор: Mizutani Shiro
Принадлежит: SHIMADZU CORPORATION

An acceleration voltage generator () generates a high-voltage pulse to be applied to a push-out electrode (), by operating a switch section () to turn on and off a high direct-current voltage generated by a high-voltage power supply (). A drive pulse signal is supplied from a controller () to the switch section () through a primary-side drive section (), transformer (), and secondary-side drive section (). The measurement period of a repeated measurement is changed according to a target m/z range. A primary-voltage controller () controls a primary-side power supply () to change a primary-side voltage according to the measurement period, thereby adjusting the voltage to be applied between the two ends of a primary winding of the transformer () by the primary-side drive section (). The pulse signal fed to the switch section () overshoots due to LC resonance. Due to this overshoot, the voltage at the point in time where the pulse signal begins to rise varies depending on the measurement period. Such a variation of the voltage at the point in time where the pulse signal begins to rise causes a discrepancy in the timing at which the rising slope crosses the threshold voltage of MOSFET. However, this discrepancy can be corrected by adjusting the primary-side voltage. As a result, high mass accuracy can be achieved irrespective of the measurement period. 1. A time-of-flight mass spectrometer which repeats a measurement covering a predetermined time-of-flight range with a predetermined period , the time-of-flight mass spectrometer comprising:a) an ion ejector for ejecting ions to be analyzed into a flight space by imparting acceleration energy to the ions by an effect of an electric field created by a voltage applied to an electrode;b) a high-voltage pulse generator for applying, to the electrode of the ion ejector, a high-voltage pulse for ejecting ions, the high-voltage pulse generator including: a direct-current power supply for generating a high direct-current voltage; ...

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Номер записи: 76
08-01-2015 дата публикации

Pulsed Mass Calibration in Time-of-Flight Mass Spectrometry

Номер: US20150008310A1
Автор: Christian Tanner, Edward B. Ledford, Jr., Marc Gonin, Martin Tanner
Принадлежит: Zoex Corp

A method is provided for calibrating mass-to-charge ratio measurements obtained from a time-of-flight mass spectrometer used as a detector for a chromatographic system. The method can include introducing a calibrant material into the time-of-flight mass spectrometer after a sample is introduced to the chromatographic system, but before the analysis of the sample is complete, such that calibrant material and sample material are not present at the ion source of the mass spectrometer, contemporaneously, and back-flushing residual or leaking calibrant through a back-flush line and away from the mass spectrometer.

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Номер записи: 77
08-01-2015 дата публикации

System and method for quantitation in mass spectrometry

Номер: US20150008317A1
Автор: Mircea Guna
Принадлежит: DH TECHNOLOGIES DEVELOPMENT PTE LTD

A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed DC voltage to the timed-ion selector, the pulsed DC voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.

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Номер записи: 78
08-01-2015 дата публикации

Apparatus and Methods for Ion Mobility Spectrometry

Номер: US20150008318A1
Автор: Makarov Alexander
Принадлежит: Thermo Fisher Scientific (Bremen) GmbH

A method of ion mobility spectrometry comprising: (i) introducing a packet of ions into a drift space; (ii) passing the ions through the drift space wherein the ions separate according to their ion mobility; and (iii) reflecting or deflecting the ions that have passed through the drift space back into the drift space wherein the ions can further separate according to their ion mobility. The reflecting or deflecting takes place in a region at lower pressure than the drift space. The drift space may be re-used multiple times to extend the separation path length. The regions of low pressure preferably allow inertial ion motion wherein the mean free path between ion collisions with gas is significantly longer than in the stages of ion mobility separation. The low pressure reflecting or deflecting region enables a time of flight focusing of ions to be provided without ion mobility separation occurring therein. 1. A method of ion mobility spectrometry comprising: (i) introducing a packet of ions into a drift space; (ii) passing the ions through the drift space wherein the ions separate according to their ion mobility; and (iii) reflecting or deflecting the ions that have passed through the drift space back into the drift space wherein the ions can further separate according to their ion mobility , wherein the reflecting or deflecting takes place in a region at lower pressure than the drift space.2. A method as claimed in wherein after step (iii) claim 1 , the method comprises repeating steps (ii) and (iii) in turn as many times each as needed to attain a required ion separation length or resolving power.3. A method as claimed in wherein step (iii) comprises reflecting or deflecting the ions that have passed through the drift space in a first direction back into the drift space in a second direction opposite to the first direction.4. A method as claimed in further comprising (iv) reflecting or deflecting the ions that have passed through the drift space in the second ...

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Номер записи: 79
11-01-2018 дата публикации

MASS SPECTROMETER AND ION MOBILITY SPECTROMETER

Номер: US20180011057A1
Автор: NISHIGUCHI Masaru
Принадлежит: SHIMADZU CORPORATION

A cylindrically-shaped auxiliary electrode and a cylindrically-shaped reflecting electrode are located anterior to a spray flow ejected from an ESI ionization probe. An inlet end of a heated capillary extends into the space between the two electrodes. The auxiliary electrode and heated capillary are grounded, while the reflecting electrode is supplied with a direct-current voltage having the same polarity as measurement target ions. As a result, a reflecting electric field which reflects ions originating from sample components and charged droplets, being carried by the spray flow, is created within the space between the two electrodes. A focusing electric field for focusing ions onto the inlet end is also created in an area near the inlet end. The ions originating from sample components are thereby separated from the gas flow and gathered around the inlet end, to be drawn into the heated capillary and sent into a vacuum chamber. 1. A mass spectrometer provided with: an ion source including an ionization probe for spraying a liquid sample into an ionization chamber in which an ambience of atmospheric pressure is present; and an ion introduction section for sending , from the ionization chamber to a vacuum chamber , ions generated by the ion source from a component contained in sample droplets sprayed from the ionization probe , where an arrangement of the ionization probe and the ion introduction section is determined so that a spraying direction of the liquid sample from the ionization probe extends orthogonally or obliquely to a direction of introducing the ions from the ionization chamber by the ion introduction section , the mass spectrometer comprising:a) an auxiliary electrode provided in the spraying direction of the sample droplets from the ionization probe and at a closer position than an inlet end of the ion introduction section, the auxiliary electrode surrounding a central axis of a spray flow from the ionization probe;b) a reflecting electrode provided ...

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Номер записи: 80
10-01-2019 дата публикации

SYSTEMS AND METHODS FOR SUBSTANCE DETECTION USING DOPED MEMBRANES

Номер: US20190011421A1
Автор: Lukow Stefan, Rogers William, Romanov Vladimir, Schmidt Hartwig
Принадлежит:

The present disclosure is directed to methods and systems for detecting a substance of interest. The methods and systems include contacting the substance of interest with a doped membrane, the doped membrane comprising at least one semi-permeable medium doped with at least one acid. The systems and methods further include desorbing the doped membrane to release the substance of interest, performing an analysis of the substance of interest, and detecting the substance of interest. 1. A device for detecting a substance of interest , the device comprising a doped membrane , wherein the membrane comprises at least one semi-permeable medium and is doped with at least one acid.2. The device of claim 1 , wherein the at least one acid comprises an organic acid.3. The device of claim 2 , wherein the organic acid comprises at least one of trifluoroacetic acid and formic acid.4. The device of claim 1 , wherein the at least one acid comprises an inorganic acid.5. The device of claim 4 , wherein the inorganic acid comprises at least one of phosphoric acid and polyphosphoric acid.6. The device of claim 1 , wherein the doped membrane has a thickness of from about 10 μm to about 1000 μm claim 1 , from about 25 μm to about 900 μm claim 1 , from about 50 μm to about 750 μm claim 1 , from about 75 μm to about 500 μm claim 1 , or from about 100 μm to about 250 μm.7. The device of claim 1 , wherein the doped membrane comprises at least a portion of an outer surface of a sample swab.8. The device of claim 1 , wherein the doped membrane comprises a doped ion exchange membrane.9. The device of claim 1 , wherein the at least one semi-permeable medium comprises a polybenzimidazole (PBI) copolymer.10. The device of claim 1 , wherein the semi-permeable medium is doped with the acid at a concentration of from about 0.50 weight percent to about 20 weight percent of the acid.11. The device of claim 1 , wherein the doped membrane has a surface pH of from about 6.0 to about 7.0.12. The device of ...

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Номер записи: 81
12-01-2017 дата публикации

Method of Optimising Spectral Data

Номер: US20170011899A1
Автор: Jason Lee Wildgoose, Keith Richardson, Martin Raymond Green, Richard Moulds
Принадлежит: Micromass UK Ltd

A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, whilst discarding less optimal data.

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Номер записи: 82
12-01-2017 дата публикации

Determining device for hydrocarbon emissions of motors

Номер: US20170011902A1
Автор: Manfred Gohl
Принадлежит: Verwaltungsgesellschaft für Emissionsanalyse UG (haftungsbeschränkt)

A determination device for hydrocarbon emissions of a thermal engine including an inspection probe for removing a sample volume from a liquid, a measurement channel for conducting the sample volume via an ion source apparatus to a broadband measurement apparatus that is configured to determine a spectrum to be measured in one step, wherein the ion source apparatus is configured for soft ionization and the measurement apparatus forms an intensity signal sequence across the mass spectrum and is configured as a simultaneously measuring “time-of-flight” detector or as a “double-focusing sector field mass spectrometer in Mattauch-Herzog geometry.”

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Номер записи: 83
09-01-2020 дата публикации

REAGENTS FOR ENHANCED DETECTION OF LOW VOLATILITY ANALYTES

Номер: US20200011844A1
Автор: KELLEY Jude A., KINGSBOROUGH Richard Paul, KUNZ Roderick Russell, OSTRINSKAYA Alla
Принадлежит:

The use of volatilization reagents is disclosed for improved detection of inorganic oxidizers such as, but not limited to, chlorates and perchlorates. Detection methods are disclosed whereby a reagent can transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of an inorganic salt analyte, forming an acid (i.e., chloric acid, perchloric acid) that is easier to detect by a mechanism whereby the acidified reagent is more easily vaporized, and hence, more easily detected. Concurrently, the anion of the acid forms a new salt with the cation released from the salt that was acidified. The reagents can also include acidic salts or cation-donators, more generally. In some embodiments, hydrated reagents or co-reagents that can release water can be employed. 1. A method for detection of an analyte molecule , X , potentially present in a sample , the method comprising:treating the sample with an acidic evaporative reagent to form a higher vapor pressure analog of the analyte if present in the sample, andsubjecting the treated sample to mass spectrometry, whereby the presence of X in the sample can be deduced,wherein the acidic evaporative reagent comprises a polymeric acid.2. The method of claim 1 , wherein said acidic evaporative reagent has a pKa of less than 2.5.3. The method of claim 1 , wherein said acidic evaporative reagent comprises a polymeric organic acid.46.-. (canceled)7. The method of claim 1 , wherein said acidic evaporative reagent comprises a hydrated acidification reagent.8. The method of claim 7 , wherein said hydrated acidification reagent comprises a hydrated sulfonate- or sulfate-containing acid.9. The method of claim 7 , wherein said hydrated acidification reagent comprises solid sodium bisulfate monohydrate.10. The method of claim 1 , wherein the step of subjecting the treated sample to mass spectrometry further comprises subjecting the treated sample to ion mobility spectrometry.11. The method of claim 1 , wherein the method further comprises ...

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Номер записи: 84
15-01-2015 дата публикации

FIRST AND SECOND ORDER FOCUSING USING FIELD FREE REGIONS IN TIME-OF-FLIGHT

Номер: US20150014522A1
Автор: Haufler Robert E., Loyd William Morgan
Принадлежит:

In some embodiments, a time of flight mass spectrometer can comprise an input orifice for receiving ions, a first ion accelerator stage for accelerating the ions along a first path, at least one ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path, a detector for detecting at least a portion of the ions redirected by said at least one ion reflector, and at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector. In some embodiments, the lengths of the field free drift regions can be selected so as to provide 1st and 2nd order corrections of the time of flight of the ions with respect to variation in their initial positions. 1. A time of flight mass spectrometer , comprising:an input orifice for receiving ions,a first ion acceleration stage for accelerating the ions along a first path,a first ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path,a second ion reflector configured to redirect the ions propagating along the second path onto a third path,a detector for detecting at least a portion of the ions redirected by said second ion reflector,at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector, anda second acceleration stage disposed between said first and second field free drift regions.2. The mass spectrometer of claim 1 , wherein said first and second field free drift regions are configured to correct for a spread in initial positions of ions entering the spectrometer relative to a reference position.3. The mass spectrometer of claim 2 , wherein the detector is positioned to receive the ions propagating along the third path.4. The mass ...

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Номер записи: 85
15-01-2015 дата публикации

TIME OF FLIGHT TUBES AND METHODS OF USING THEM

Номер: US20150014524A1
Автор: Chiappetta Anthony, Ferrara Keith, STEINER Urs
Принадлежит: PerkinElmer Health Sciences, Inc.

Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged. 1. A time of flight tube comprising:an inner tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the inner tube, the inner tube comprising a conductive material disposed on an inner surface of the inner tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged;an outer tube surrounding the inner tube, the outer tube effective to insulate the inner tube and electrically isolate the inner tube; andan air gap between the inner tube and the outer tube.2. The time of flight tube of claim 1 , in which the inner tube comprises a material with a coefficient of thermal expansion that is effective to maintain a substantially constant height of the inner tube during operation of the time of flight tube.3. The time of flight tube of claim 2 , in which the coefficient of thermal expansion of the material is effective to permit longitudinal expansion of the inner tube by about two microns or less.4. The time of flight tube of claim 1 , in which the conductive material on the inner surface of the inner tube comprises a coated conductive material.5. The time of flight tube of claim 1 , in which the outer surface of the inner tube is non-conductive.6. The time of flight tube of claim 1 , further comprising a cap coupled to the inner tube.7. The time of flight tube ...

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Номер записи: 86
15-01-2015 дата публикации

SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS

Номер: US20150014525A1
Автор: Charipar Nicholas Alan, Cooks Robert Graham, Garimella Sandilya Venkata, Harper Jason David, Ouyang Zheng
Принадлежит:

The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. 128-. (canceled)29. A system for analyzing a sample , the system comprising:an ionizing source for converting molecules of a sample into sample ions, the ionizing source comprising a gas inlet port and an electrode positioned within the source to interact with a gas introduced through the gas inlet port and to generate a discharge that interacts with the sample to produce the sample ions;an ion analysis device; andan ion transfer member operably coupled to a gas flow generating device, wherein the gas flow generating device produces a laminar gas flow without regions of recirculation that transfers the sample ions through the ion transfer member to an inlet of the ion analysis device.30. The system according to claim 29 , further comprising a gas source operably coupled to the gas inlet port.31. The system according to claim 30 , wherein the gas is helium.32. The system according to claim 29 , wherein the gas flow generating device is a pump.33. The system according to claim 29 , wherein the gas flow generating device is a gas jet of the ionizing source.34. The system according to claim 29 , wherein the ion transfer member is a tube.35. The system according to claim 34 , wherein the tube is composed of a rigid material.36. The system according to claim 35 , wherein the rigid material is metal or glass.37. The system according to claim 34 , wherein the tube is composed of a flexible material.38. The ...

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Номер записи: 87
14-01-2016 дата публикации

Improved Lock Component Corrections

Номер: US20160013036A1
Автор: Wildgoose Jason Lee
Принадлежит:

A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time Tand at the same time measuring a time of flight or mass to charge ratio Mof one or more lockmass ions. The mass spectrometer is then operated at a subsequent time Tand the time of flight or mass to charge ratio Mof the one or more lockmass ions is measured at subsequent time T. The time of flight or mass to charge ratio of ions is then adjusted by or based upon the difference between the time of flight or mass to charge ratio Mof the one or more lockmass ions as measured at time Tand the time of flight or mass to charge ratio Mof the one or more lockmass ions as measured at time T. 1. A method of mass spectrometry comprising:{'sub': 0', '0, 'initially calibrating or re-calibrating a mass spectrometer at a time Tand at substantially the same time measuring a time of flight or mass to charge ratio Mof one or more lockmass ions;'}{'sub': '1', 'operating the mass spectrometer at a subsequent time T;'}{'sub': 1', '1, 'measuring the time of flight or mass to charge ratio Mof said one or more lockmass ions at said time T; and'}{'sub': 1', '1', '0', '0, 'adjusting the time of flight or mass to charge ratio of ions by or based upon the difference between the time of flight or mass to charge ratio Mof said one or more lockmass ions as measured at said time Tand said time of flight or mass to charge ratio Mof said one or more lockmass ions as measured at said time T.'}2. A method as claimed in claim 1 , wherein the step of initially calibrating or re-calibrating said mass spectrometer at said time Tcomprises performing a calibration routine to produce a calibration curve.3. A method as claimed in claim 2 , wherein said calibration curve corresponds to a curve of best fit which relates the measured mass to charge ratio or time of flight of a plurality of known ions with the actual or known mass to charge ratio or time of flight of said plurality of known ...

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Номер записи: 88
11-01-2018 дата публикации

Charged Particle Beam Device

Номер: US20180012725A1
Автор: KAWANO Hajime, Kazumi Hideyuki, MIZUHARA Yuzuru, Yokosuka Toshiyuki
Принадлежит: HITACHI HIGH-TECHNOLOGIES CORPORATION

Provided is a charged particle beam device that enables, even if a visual field includes therein a plurality of regions having different secondary electron emission conditions, the setting of appropriate energy filter conditions adapted to each of these regions. The charged particle beam device is equipped with a detector for detecting charged particles obtained on the basis of scanning, over a sample, a charged particle beam emitted from a charged particle source, and an energy filter for filtering by energy the charged particles emitted from the sample. Index values are determined for the plurality of regions contained within the scanning region of the charged particle beam, and, for each of a plurality of energy filter conditions, differences are calculated between the plurality of index values and the reference index values that have been set for each of the plurality of regions. 1. A charged particle beam device including a detector for detecting charged particles obtained on the basis of scanning of a beam emitted from a charged particle source and an energy filter for energy-filtering the charged particles emitted from a sample , the device comprising:an arithmetic processor that calculates index values in a plurality of regions contained in a scanning region of the charged particle beam and that calculates differences between the plurality of index values and reference index values set for each of the plural regions with respect to each of a plurality of energy filter conditions.2. The charged particle beam device according to claim 1 ,wherein the arithmetic processor calculates standard deviations of the index values based on the difference calculation.3. The charged particle beam device according to claim 2 ,wherein the arithmetic processor selects the energy filter conditions in which the index value is the minimum or which satisfy given conditions.4. The charged particle beam device according to claim 1 ,wherein the index values are at least one of ...

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Номер записи: 89
11-01-2018 дата публикации

SYSTEMS AND METHODS FOR BUBBLE BASED ION SOURCES

Номер: US20180012748A1
Автор: Abbott William, Fries David P., Yang Bo
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, an ion channel, an electrode, and/or any other components. The ion source can include a container at least partially comprising a solvent or solution, a bubble generator coupled to the container configured to generate a plurality of bubbles within the solvent, and/or any other component. The ion channel can receive ions that are generated based on solvent from the bubbles. 1. A bubble based ion source system comprising: a container at least partially comprising a solvent;', 'a bubble generator coupled to the container configured to generate a plurality of bubbles within the solvent; and, 'an ion source configured to generate a plurality of ions comprisingan ion channel comprising an aperture and an electrode, the ion channel configured to receive the plurality of ions through the aperture, the plurality of ions being generated based at least in part on at least a portion of the solvent from at least one of the plurality of bubbles.2. The bubble based ion source system of claim 1 , wherein the electrode is configured to facilitate guiding the plurality of ions to an analyzer device.3. The bubble based ion source system of claim 2 , wherein the analyzer device is at least one of: an ion mobility spectrometer claim 2 , a mass spectrometer claim 2 , a charged particle deposition system claim 2 , or a charge energy generation device.4. The bubble based ion source system of claim 1 , wherein at least one voltage applied to the ion channel facilitates moving the plurality of ions into an analyzer device.5. The bubble based ion source system of claim 1 , further comprising a heat source positioned above the container claim 1 , wherein the plurality of ions are generated further based at least in part on the heat source.6. The bubble based ion source system of claim 1 , wherein the bubble generator is configured to ...

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Номер записи: 90
10-01-2019 дата публикации

LIQUID SAMPLE INTRODUCTION SYSTEM FOR ION SOURCE AND ANALYSIS DEVICE

Номер: US20190013189A1
Автор: Okumura Daisuke, SAKAGOSHI Yusuke
Принадлежит: SHIMADZU CORPORATION

A liquid sample introduction system for an ion source which ionizes a liquid sample by supplying the liquid sample to an ionization probe in an ion source and making an atomization-promoting gas blow at the liquid sample exiting from the tip of the ionization probe the liquid sample introduction system including: a liquid sample container -which is a hermetically closable container for holding a liquid sample; a liquid-supply-gas passage having one end connected to a point in a passage for supplying an atomization-promoting gas to the ion source, and the other end connected to a space above a liquid level in the liquid sample container -and a sample supply passage having one end connected to a space below the liquid level in the liquid sample container -and the other end connected to the ionization probe 1. A liquid sample introduction system for an ion source which ionizes a liquid sample by supplying the liquid sample to an ionization probe in an ion source and making an atomization-promoting gas blow at the liquid sample exiting from a tip of the ionization probe , the liquid sample introduction system comprising:a) a plurality of liquid sample containers, each of which is a hermetically closable container for holding a liquid sample;b) a liquid-supply-gas passage having one end connected to a point in a passage for supplying an atomization-promoting gas to the ion source, and another end connected to a space above a liquid level in one of the liquid sample containers; andc) a sample supply passage having one end connected to a space below the liquid level in one of the liquid sample containers and another end connected to the ionization probe,wherethe other end of the liquid-supply-gas passage is branched into a plurality of liquid-supply-gas sub-passages each of which is connected to the space above the liquid level in one of the liquid sample containers;the one end of the sample supply passage is branched into a plurality of sample-supply sub-passages each of ...

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Номер записи: 91
14-01-2021 дата публикации

TIME-OF-FLIGHT MASS SPECTROMETER

Номер: US20210013019A1
Автор: KOZAWA Hiroaki, MIYAZAKI Yuta, Okumura Daisuke, OSHIRO Tomoyuki
Принадлежит: SHIMADZU CORPORATION

For an automatic adjustment of a detector voltage, a measurement of a standard sample is performed, in which a reflection voltage generator under the control of an autotuning controller applies, to a reflector, voltages which are different from those applied in a normal measurement and do not cause temporal conversion of ions. Ions having the same m/z simultaneously ejected from an ejector are dispersed in the temporal direction and reach a detector. Therefore, a plurality of low peaks corresponding to individual ions are observed on a profile spectrum. A peak-value data acquirer determines a wave-height value of each peak. A wave-height-value list creator creates a list of wave-height values. A detector voltage determiner searches for a detector voltage at which the median of the wave-height values in the wave-height-value list falls within a reference range. 1. A time-of-flight mass spectrometer including an ejector configured to impart acceleration energy to ions originating from a sample component to eject the ions into a flight space , a flight-space-forming electrode configured to create , within the flight space , an electric field of a predetermined condition which makes the ions ejected by the ejector fly in the flight space , and a detector configured to detect the ions after the ions' flight in the flight space , the time-of-flight mass spectrometer comprising:a) a controller configured to control a voltage applied to an electrode in the ejector and/or a voltage applied to the flight-space-forming electrode, so as to create a non-converging condition under which ions having a same mass-to-charge ratio are not temporally converged, when adjusting a detector voltage for adjusting a gain of the detector; andb) a detector voltage determiner configured to conduct a measurement of a predetermined sample under the non-converging condition and determine an appropriate detector voltage based on one or more of a number, height and area of peaks observed on each of ...

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Номер записи: 92
14-01-2021 дата публикации

MASS SPECTROMETER

Номер: US20210013022A1
Автор: Tateishi Yusuke
Принадлежит: SHIMADZU CORPORATION

Provided is a mass spectrometer which repeats the operation of capturing ions originating from a sample component into an ion trap (), ejecting the ions from the ion trap, and analyzing the ions with a TOF mass analyzer (). A capturing voltage generator () applies an ion-capturing radio-frequency voltage to the ion trap. An ejecting voltage generator () applies an ion-ejecting voltage whose phase is synchronized with the radio-frequency voltage. A controller () controls those devices to introduce next ions to be analyzed into the ion trap while performing a mass spectrometric analysis in the TOF mass analyzer. A blank signal acquirer () acquires a blank signal within a measurement period or measurement window while the ion trap is being operated. A noise remover () subtracts blank-signal data from signal intensity data acquired by a sample measurement. A spectrum creator () creates a mass spectrum based on noise-removed data. 1. A mass spectrometer including an ion trap configured to capture an ion by a radio-frequency electric field and a time-of-flight mass analyzer configured to perform a mass spectrometric analysis on an ion ejected from the ion trap , the mass spectrometer configured to repeatedly perform an operation of capturing an ion originating from a sample component into the ion trap , ejecting the ion from the ion trap and analyzing the ion with the time-of-flight mass analyzer , and the mass spectrometer comprising:a capturing voltage generator configured to apply an ion-capturing radio-frequency voltage to at least one of the electrodes forming the ion trap;an ejecting voltage generator configured to apply an ion-ejecting voltage to at least one of the electrodes forming the ion trap, where a phase of the ion-ejecting voltage is synchronized with a phase of the radio-frequency voltage;a controller configured to control the capturing voltage generator and the ejecting voltage generator so as to introduce an ion to be subsequently analyzed into the ion ...

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Номер записи: 93
09-01-2020 дата публикации

TANDEM MASS SPECTROMETER AND PROGRAM FOR THE SAME

Номер: US20200013599A1
Автор: Toyama Atsuhiko, Yamamoto Hideki
Принадлежит: SHIMADZU CORPORATION

As soon as a set of data is acquired by a mass spectrometric analysis, an accumulated value of the signal intensity on the mass spectrum is calculated for each m/z segment obtained by dividing the entire m/z range covered by the measurement by a predetermined m/z width. Only the m/z segments with accumulated signal-intensity values equal to or greater than a predetermined threshold are selected as the target for an MS/MS analysis. MS/MS analysis is performed for each selected m/z segment, using ions whose m/z values fall within the m/z segment as precursor ions. A measurement cycle which includes mass spectrometric analysis performed one time and MS/MS analysis performed one or more times is repeated. After that, ions originating from the same component are selected based on the retention time of a peak in an extracted ion chromatogram created for each product ion, and the component is identified. 1. A tandem mass spectrometer including a first mass-separating section configured to select , as a precursor ion , an ion having a specific mass-to-charge ratio or ions having a specific mass-to-charge-ratio range among ions originating from a sample , an ion-dissociating section configured to dissociate the precursor ion , and a second mass-separating section configured to perform a mass spectrometric analysis for various product ions generated by dissociation of the precursor ion , the tandem mass spectrometer comprising:a) a mass spectrometry controller configured to control each of the aforementioned sections so as to acquire mass spectrum data by performing a mass spectrometric analysis in the second mass-separating section, without performing selection of an ion in the first mass-separating section and dissociation of an ion in the ion-dissociating section;b) a mass-to-charge-ratio segment determiner configured to select one or more mass-to-charge-ratio segments from a plurality of mass-to-charge-ratio segments obtained by dividing an entire mass-to-charge-ratio ...

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Номер записи: 94
09-01-2020 дата публикации

Physical Isolation of Adducts and Other Complicating Factors in Precursor Ion Selection for IDA

Номер: US20200013609A1
Автор: Tate Stephen Alexander
Принадлежит:

A system is disclosed for identifying precursor ions originating from an ion source device. A mass filter filters an ion beam by using a series of overlapping precursor ion mass selection windows across the precursor ion mass range. A mass analyzer analyzes the precursor ions of each precursor ion mass selection window of the series, producing a plurality of precursor ion spectra for the precursor ion mass range. A precursor ion is selected from the spectra. The intensities for the selected precursor ion are retrieved from the spectra and a trace is produced that describes how the intensity of the selected precursor ion varies with the location of the precursor ion mass selection window. The selected precursor ion is identified as a precursor ion originating from the ion source device if the trace includes a nonzero intensity for the m/z value of the selected precursor ion. 1. A system for identifying precursor ions originating from an ion source device using a scanning sequential windowed precursor ion selection and mass analysis survey scan , comprising:an ion source device that ionizes and transforms a sample into an ion beam;a mass filter receives the ion beam;a mass analyzer; anda processor in communication with the mass filter and the mass analyzer that(a) instructs the mass filter to filter the ion beam by scanning a precursor ion mass selection window with a width smaller than a precursor ion mass range of interest across a precursor ion mass range of interest in overlapping steps, producing a series of overlapping precursor ion mass selection windows across the precursor ion mass range, and instructs the mass filter to transmit precursor ions from each precursor ion mass selection window of the series of overlapping precursor ion mass selection windows to the mass analyzer,(b) instructs the mass analyzer to analyze the precursor ions of each precursor ion mass selection window of the series of overlapping precursor ion mass selection windows, producing a ...

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Номер записи: 95
03-02-2022 дата публикации

Method and apparatus for data independent combined ion mobility and mass spectroscopy analysis

Номер: US20220034840A1
Автор: TENZER Stefan
Принадлежит:

An apparatus and a method of data independent combined ion mobility and mass spectroscopy analysis includes introducing precursor ions into an ion mobility spectrometer (IMS), sequentially releasing precursor ions from said IMS according to their ion mobility, introducing said released precursor ions into a mass filter, fragmenting the precursor ions transmitted through said mass filter to generate fragment ions, and carrying out a mass spectroscopy measurement on said fragment ions. The IMS and mass filter are controlled in a synchronized manner to carry out a plurality of IM scans, wherein adjacent mass windows in said IM scan that are associated with consecutive mass spectroscopy measurements of fragment ions overlap, such that precursor ions transmitted through said mass filter during said IM scan are located in at least one continuous scan region in an m/z-IM plane which extends in a generally diagonal direction in said m/z-IM plane. 1. A method of data independent combined ion mobility and mass spectroscopy analysis , comprising the following steps:introducing precursor ions into an ion mobility separator (IMS), sequentially releasing precursor ions from said IMS according to their ion mobility,introducing said released precursor ions into a mass filter which selectively transmits precursor ions having m/z values falling within a controllable mass window,fragmenting the precursor ions transmitted through said mass filter to generate fragment ions,carrying out a mass spectroscopy measurement on said fragment ions, wherein each fragment ion is associated with a mass window and an ion mobility (IM) range, and associating detected fragments with its corresponding precursor ion,wherein said IMS and said mass filter are controlled in a synchronized manner such as to carry out a plurality of IM scans, during which precursor ions of increasing or decreasing IM are successively released from said IMS, and during which the mass window of said mass filter is shifted ...

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Номер записи: 96
21-01-2016 дата публикации

Molecular markers in bladder cancer

Номер: US20160017434A1
Автор: Daphne Hessels, Franciscus Petrus Smit, Jacobus A. SCHALKEN
Принадлежит: Mdxhealth Research BV, NOVIOGENDIX RESEARCH BV

The Present invention relates methods for establishing the presence, or absence, of a bladder tumour and/or classification of the tumor according to the aggressiveness and/or establishing the prediction of prognosis and disease outcome for a human individual suffering from bladder cancer. Specifically, the present invention relates to methods for establishing the presence, or absence, of a bladder tumour in a human individual comprising: determining the expression of one or more genes chosen from the group consisting of ADAMTS12, ASPN, CDC20, COL10A1, CTHRC1, FAP, SFRP4, FOXM1, KRT6A, ANLN, CHI3L1, TPX2, CCNB2, IGF2BP2, INHBA, PDCD1LG2, transcript cluster 2526893, and transcript cluster 2526896 in a biological sample (tissue or bodyfluid) originating from said human individual; establishing up regulation of expression of said one or more genes as compared to expression of said respective one or more genes in a sample originating from said human individual not comprising tumour cells or tissue.

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Номер записи: 97
19-01-2017 дата публикации

DETECTION APPARATUS AND DETECTION METHOD

Номер: US20170016856A1
Автор: Chang Jianping, Chen Zhiqiang, HE Huishao, Li Yuanjing, Liang Song, Liu Yaohong, LIU Yinong, MA Qiufeng, Zhang Qingjun, Zhao Ziran, ZHU Weiping, ZOU XIANG
Принадлежит:

A detection apparatus and a detection method are disclosed. In one aspect, the detection apparatus includes a sampling device for collecting samples to be checked. It further includes a sample pre-processing device configured to pre-process the sample from the sampling device. It further includes a sample analyzing device for separating samples from the pre-processing device and for analyzing the separated samples. The detection apparatus is miniaturized and highly precise, and is capable of quickly and accurately detecting gaseous phase or particulate substances, and it has applications for safety inspections at airports, ports, and subway stations. 1. A detection apparatus comprising:a sampling device for collecting a sample to be detected;a sample pre-processing device configured to pre-process the sample from the sampling device; anda sample analyzing device for separating the pre-processed sample and analyzing the separated sample.2. The detection apparatus of claim 1 , wherein the sampling device comprises a chamber body comprising:a sample inlet that is at a first end of the chamber body and is for suction of the sample;a sample outlet that is adjacent to a second end, opposite to first end, of the chamber body and is for discharge of the sample;an air inflation opening configured to induct a flow of air into the chamber body; andan air exhaust opening configured to discharge the air and to, together with the air inflation opening in the chamber body, form a tornado type air flow moving spirally from the first end to the second end of the chamber body,wherein a section of the chamber body has an inner wall with a truncated conical shape, the truncated conical shaped inner wall having a smaller-diameter round end being adjacent to the sample inlet and a larger-diameter round end being adjacent to the sample outlet of the chamber body, andwherein the air inflation opening is configured such that an axially air induction direction of the air inflation opening is ...

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Номер записи: 98
21-01-2016 дата публикации

Deep MALDI TOF Mass Spectrometry of Complex Biological Samples, e.g., Serum, and Uses Thereof

Номер: US20160018410A1
Автор: Allen Jenna, Asmellash Senait, Röder Heinrich, Tsypin Maxim
Принадлежит:

A method of analyzing a biological sample, for example serum or other blood-based samples, using a MALDI-TOF mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a MALDI-TOF sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument. In some embodiments at least 100,000 laser shots and even 500,000 shots are directed onto the sample. It has been discovered that this approach, referred to as “deep-MALDI”, leads to a reduction in the noise level in the mass spectra and that a significant amount of additional spectral information can be obtained from the sample. Moreover, peaks visible at lower number of shots become better defined and allow for more reliable comparisons between samples.

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Номер записи: 99
18-01-2018 дата публикации

METHOD AND APPARATUS FOR DETECTING ORGANOPHOSPHORUS COMPOUNDS AND ILLICIT DRUGS

Номер: US20180017529A1
Автор: Atkinson David A., Ewing Robert G., Valenzuela Blandina R.
Принадлежит: BATTELLE MEMORIAL INSTITUTE

A method is disclosed for detecting organophosphorus compounds and illicit drugs using an ion detector. A vapor sample containing at least one analyte and at least one dopant is ionized. A proton-bound adduct ion is formed between the analyte and the dopant in a reaction region defined between the ionization source and the ion detector. 1. A method of detecting an organophosphorus compound (OPC) and/or an illicit drug with an ion detector , the method comprising the steps of:forming a proton-bound adduct ion between at least one OPC and at least one secondary or tertiary amine in a reaction region defined between an ionization source and the ion detector; anddetecting the proton-bound adduct ion with the ion detector to confirm presence of the OPC and/or the illicit drug.2. The method of wherein the at least one secondary or tertiary amine includes a proton affinity greater than the organophosphorus compound ion.3. The method of claim 1 , wherein the at least one secondary or tertiary amine includes a proton affinity between 220 kcal/mol and 250 kcal/mol.4. The method of wherein the at least one OPC is an analyte and the at least one secondary or tertiary amine is a dopant.5. The method of wherein the OPC is a phosphonate or an organophosphate.6. The method of wherein the dopant is a dialkylamine claim 4 , alkyl-substituted derivative of pyridine claim 4 , or a trialkylamine.7. The method of wherein the dialkylamine or trialkylamine have R groups with between 1 and 12 carbons including: diethylamine claim 6 , diisopropyl amine claim 6 , diethylmethyl amine claim 6 , triethylamine claim 6 , tripropylamine claim 6 , tributylamine claim 6 , trioctylamine claim 6 , tridecylamine claim 6 , tridodecylamine claim 6 , and combinations thereof.8. The method of wherein the OPC is detectable at 100 parts-per-quadrillion or better.9. The method of wherein the illicit drug is an analyte and the at least one OPC is a dopant.10. The method of wherein the OPC is a phosphonate or an ...

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Номер записи: 100