Vegf neutralizing prodrugs for the treatment of ocular conditions
Номер патента: NZ706853A
Опубликовано: 27-04-2018
Автор(ы): Burkhardt Laufer, Harald Rau, Kennett Sprogøe, Nicola BISEK, Romy Reimann, Samuel WEISBROD, Sebastian Stark, Thomas KNAPPE, Tobias Voigt
Принадлежит: Ascendis Pharma Ophthalmology Div A/S
Опубликовано: 27-04-2018
Автор(ы): Burkhardt Laufer, Harald Rau, Kennett Sprogøe, Nicola BISEK, Romy Reimann, Samuel WEISBROD, Sebastian Stark, Thomas KNAPPE, Tobias Voigt
Принадлежит: Ascendis Pharma Ophthalmology Div A/S
Реферат: The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a carrier-linked VEGF neutralizing prodrug, the carrier-linked prodrug comprising a covalently bound VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions., wherein the carrier-linked prodrug comprises a covalently bound VEGF neutralizing biologically active moiety, a reversible prodrug linker moiety and a carrier group which is a hydrogel, which VEGF neutralizing biologically active moiety is reversibly connected to a carrier through a reversible prodrug linker moiety, wherein there is optionally a spacer moiety between the carrier moiety and the reversible prodrug linker and wherein the reversible prodrug linker is of formula (F) below, for use in a method for the treatment of one or more ocular conditions.
C3d cellular and acellular vaccines for the prevention and treatment of cancer
Номер патента: WO2017189281A1. Автор: Marilia CASCALHO,Jeffrey L. Platt. Владелец: THE REGENTS OF THE UNIVERSITY OF MICHIGAN. Дата публикации: 2017-11-02.