Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor
Номер патента: EP2342186A2
Опубликовано: 13-07-2011
Автор(ы): Devising Rameshsing Pardeshi, Golakchandra Sudarshan Maikap, Mangesh Gorakhanath Kamble, Mukund Keshav Gurjar, Samit Satish Mehta, Shashikant Gangaram Joshi
Принадлежит: Emcure Pharmaceuticals Ltd
Опубликовано: 13-07-2011
Автор(ы): Devising Rameshsing Pardeshi, Golakchandra Sudarshan Maikap, Mangesh Gorakhanath Kamble, Mukund Keshav Gurjar, Samit Satish Mehta, Shashikant Gangaram Joshi
Принадлежит: Emcure Pharmaceuticals Ltd
Реферат: A method for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor such as etravirine is provided Typically, etravirine is synthesized by the steps of a Condensing 2,4,6-trichlorpyrimidine with 3,5-dimethyl-4-hydroxybenzonitrile to obtain compound (V), b Condensing compound (V) with 4-aminobenzonitrile to obtain compound (VI), c Ammonolysis of compound (VI) to get compound (IV), d Halogenation of compound (IV) to get etravirine.
Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor
Номер патента: WO2010150279A3. Автор: Mukund Keshav Gurjar,Samit Satish Mehta,Golakchandra Sudarshan Maikap,Shashikant Gangaram Joshi,Devising Rameshsing Pardeshi,Mangesh Gorakhanath Kamble. Владелец: Emcure Pharmaceuticals Limited. Дата публикации: 2011-02-24.