Pyridino[2,3-d]pyrimidine derivatives as selectiive kdr and fgfr inhibitors
Номер патента: EP1581531A1
Опубликовано: 05-10-2005
Автор(ы): Jin-Jun Liu, Kin-Chun Luk
Принадлежит: F Hoffmann La Roche AG
Опубликовано: 05-10-2005
Автор(ы): Jin-Jun Liu, Kin-Chun Luk
Принадлежит: F Hoffmann La Roche AG
Реферат: Disclosed are novel dihydropridinone compounds of the formula (I) wherein Ar, Ar' and R1 are as defined in the description, that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon lung and prostate tumors. Also, disclosed are pharmaceutical compositions containing these compounds and their preparation.
Pyridino[2,3-d]pyrimidine derivatives as selective kdr and fgfr inhibitors
Номер патента: CA2508951A1. Автор: Kin-Chun Luk,Jin-Jun Liu. Владелец: Individual. Дата публикации: 2004-07-08.