Phenyl-substituted piperidine compounds and their preparation and use in treating calcium overload in brain cells of mammals
Номер патента: CA1323367C
Опубликовано: 19-10-1993
Автор(ы): Jýrgen Drejer, Palle Jakobsen
Принадлежит: Novo Nordisk AS
Опубликовано: 19-10-1993
Автор(ы): Jýrgen Drejer, Palle Jakobsen
Принадлежит: Novo Nordisk AS
Реферат: ABSTRACT Novel piperidine compounds having the formula wherein R3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C1-6-alkyl, C1-6-alkoxy, C3-8-cycloalkyl, C3-5-alkylene or aral-koxy, R1 is straight or branched C1-8-alkyl, C4-8-alkoxy-C4-8-al-kyl, C4-7-cycloalkyl, aryloxy-C3-8-alkyl, C4-8-alkenyl, or C4-8-cycloalkylalkyl, or R1 may also be hydrogen or C1-3-alkyl, when R3 is aryl, which is substituted with two or more of C1-6- alkyl, C1-6-alkoxy, C3-8-cycloalkyl, aralkoxy, or with C3-5- alkylene. X is hydrogen or halogen, and wherein Y is O or S and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.
Phenyl substituted piperidine compounds for use as ppar activators
Номер патента: CA2507465C. Автор: Zhengyu Liu,Cheryl Myers Hayward,Scott William Bagley,Thomas Andrew Brandt,Robert Wayne Dugger,William Andrew Hada. Владелец: Pfizer Products Inc. Дата публикации: 2009-04-28.