Novel imidazolidine derivatives, their preparation and their use as VLA-4 antagonists .

Novel imidazolidine derivatives, their preparation and their use as VLA-4 antagonists

Номер патента: JP4676697B2
Опубликовано: 27-04-2011
Автор(ы): シュテファーニエ・フローア, ハルトムート・リュッテン, ハンス・ウルリッヒ・シユテイルツ, フォルクマール・ヴェーナー, ホルスト・ブルム
Принадлежит: サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
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Рисунок 1. Взаимосвязь патентов (ближайшие 20).

Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Номер патента: CA2455966C. Автор: Hans Ulrich Stilz,Volkmar Wehner,Stefanie Flohr,Horst Blum,Hartmut Ruetten. Владелец: Sanofi Aventis Deutschland GmbH. Дата публикации: 2011-09-20.

Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Номер патента: CA2455966A1. Автор: Hans Ulrich Stilz,Volkmar Wehner,Stefanie Flohr,Horst Blum,Hartmut Ruetten. Владелец: Individual. Дата публикации: 2003-02-13.

Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Номер патента: IL160093A0. Автор: . Владелец: Aventis Pharma Gmbh. Дата публикации: 2004-06-20.

Novel imidazolidine derivatives and their preparation and use as VLA-4 antagonists.

Номер патента: NO20040426L. Автор: Volkmar Wehner,Stefanie Flohr,Hans-Ulrich Stilz,Horst Blum,Hartmut Ruetten. Владелец: Avantis Pharma Deutschland Gmb. Дата публикации: 2004-03-26.

NEW IMIDAZOLIDINE DERIVATIVES, THEIR PRODUCTION AND USE OF THEM AS VLA-4 ANTAGONISTS

Номер патента: RU2004105966A. Автор: Ханс Ульрих ШТИЛЬЦ,Штефани ФЛОР,Фолькмар ВЕНЕР,Хартмут РЮТТЕН,Хорст БЛУМ,Ханс Ульрих ШТИЛЬЦ (DE),Фолькмар ВЕНЕР (DE),Штефани ФЛОР (DE),Хорст БЛУМ (DE),Хартмут РЮТТЕН (DE). Владелец: АВЕНТИС ФАРМА ДОЙЧЛАНД ГмбХ (DE). Дата публикации: 2005-06-27.

Imidazolidine derivatives, process for their preparation and pharmaceutical preparation

Номер патента: NO326001B1. Автор: Volkmar Wehner,Hans-Ulrich Stilz,Horst Blum,Hartmut Ruetten. Владелец: Sanofi Aventis Deutschland. Дата публикации: 2008-09-01.

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Pyrimidine compounds and their use as modulators of chemokine receptor activity

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Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides

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Substituted quinoxalyl-imidazolidine-2,4-diones, processes for their preparation, their use as medicaments and pharmaceutical preparations

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Novel heterocyclic compounds, compositions, methods of preparation and uses thereof

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Novel heterocyclic compounds, compositions, methods of preparation and uses thereof

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Novel heterocyclic compounds, compositions, methods of preparation and uses thereof

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Derivatives of aminoquinoline and aminopyridine and their using as adenosine ligands a3

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Derivatives of naphthyridine, method for their preparing and using

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Indolyl-derivatives, method for their preparing, pharmaceutical composition, method of treatment and/or prophylaxis of diseases

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Anthranylamides and their using as medicinal agents

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Benzoyl guanidines, method for their preparing, medicinal agent comprising thereof and method for treatment and prophylaxis of diseases

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Anthranilamides, process for their preparation, their use as antiarrhythmics, and pharmaceutical preparations thereof

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Fluoro-pyridinone derivatives useful as antibacterial agents

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Novel heterocycles as inhibitors of leucocyte adhesion and as vla-4 antagonists

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Heterocyclic compounds, their preparation and their use as leucocyte adhesion inhibitors and VLA-4-antagonists

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Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use

Номер патента: US09738724B2. Автор: Christopher D. Thanos,Kalyani Penta,Avinash GILL,Ramesh Baliga,Leslie Mcevoy,Gang Yin,Sunil Bajad,Sonia Pollitt,Chris Murray,Alex STEINER. Владелец: Sutro Biopharma Inc. Дата публикации: 2017-08-22.

Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use

Номер патента: US09732161B2. Автор: Christopher D. Thanos,Kalyani Penta,Avinash GILL,Ramesh Baliga,Leslie Mcevoy,Gang Yin,Sunil Bajad,Sonia Pollitt,Chris Murray,Alex STEINER. Владелец: Sutro Biopharma Inc. Дата публикации: 2017-08-15.

Novel peroxide derivatives, their process of preparation and their use in human medicine and in cosmetics for the treatment or prevention of acne

Номер патента: CA2782948C. Автор: Jean-Claude Pascal,Nicolas Rodeville,Claire Bouix-Peter. Владелец: Galderma Research and Development SNC. Дата публикации: 2015-02-10.

Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use

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Phenothiazines and their derivatives for use as a medicament

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Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents

Номер патента: US5834456A. Автор: Garry E. Kiefer,A. Dean Sherry. Владелец: University of Texas System. Дата публикации: 1998-11-10.

Imidazolone phenylalanine derivatives as vla-4 antagonists.

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Benzoxazine derivatives, their preparation, and their application in therapy

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Novel dibenzoacridinium derivatives, their process of preparation and their use for treating viral infections

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Novel dibenzoacridinium derivatives, their process of preparation and their use for treating viral infections

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Novel dibenzoacridinium derivatives, their process of preparation and their use for treating viral infections

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Novel atp-sensitive potassium channel potentiators, their preparation and use

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Aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, intermediates for their preparation and their use in medicaments

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Hypnotic β-carboline derivatives, their method of preparation and their use as medicinal products

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NOVEL AMINOSUBSTITUTED STEROIDS, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

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Decahydroquinoline derivatives, method for their preparation and intermediates thereof, their use as medicaments and their pharmaceutical compositions

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New use and new derivatives of imidazole their preparation the new intermediates obtained their use as medicaments and the pharmaceutical compositions containing them

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Indane derivatives, process for their preparation and intermediates obtained, their use as medicines, and pharmaceutical compositions containing them

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Polysubstituted indan-1-ol compounds, and methods for their preparation and use

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Polysubstituted idan-1-ol compounds, and methods for their preparation and use

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Polysubstituted indan-1-ol compounds, and methods for their preparation and use

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3,4-diarylthiazolin-2-one or -2-thione derivatives their methods of preparation and their uses in therapeutics

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New 2-aminothiazolyl-2-oxyiminoacetamido bicyclooctene carboxylic acid compounds their preparation their compositions and their use as medicaments

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Vla-4 antagonists

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Substituted pyridines and their uses

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BENZAZOCINE DERIVATIVES, THEIR METHOD OF PREPARATION AND THEIR THERAPEUTIC APPLICATION

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NEW HETEROCYCLIC ACETIC ACID DERIVATIVES, THEIR PROCESS FOR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

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CLAVULANIC ACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION

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Piperazine derivatives, their process of preparation and their composition

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NEW CEPHALOSPORIN DERIVATIVES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT

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Bicyclic derivatives, methods for their preparing, pharmaceutical composition containing thereof, their using in treatment and method for treatment of mammals by their using

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Substituted sulfoxide compounds, methods for their preparation, and methods for their use

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PYRIDAZINONE DERIVATIVES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

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Acylaminoindole derivatives representing 5-ht1 agonists, process of their preparation, pharmaceutical compositions containing thereof, their use and intermediates of the preparation process

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NEW NAPHTHALENE DERIVATIVES, THEIR METHODS OF PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

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METHOD FOR PRODUCING NEW THIAZOLIDINE DERIVATIVES, THEIR TAUTOMERIC AND ISOMERIC FORMS AND THEIR ACID ADDITION SALTS

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Alkoxybenzylpyridopyrimidines, methods for their preparation, formulations thereof and their use in medicine

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camptothecin derivatives, process for their preparation, pharmaceutical composition and their use

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10-DESACETYL-14BETA-HYDROXYBACCATIN III DERIVATIVES THEIR METHOD OF PREPARATION AND FORMULATIONS CONTAINING THEM

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Compounds useful as antiproliferative agents and garft inhibitors

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NEW THIAZOLIC DERIVATIVES, THEIR PROCESS FOR PREPARATION AND ANTHELMINTH COMPOSITION CONTAINING THEM

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8.alpha.-acylamino ergolines, their production and use as drugs

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NOVEL 2-AMINO-BENZOYL-3 PHENYLACETAMIDES AND THEIR CYCLIC HOMOLOGUES USEFUL AS MEDICAMENTS AND THERAPEUTIC COMPOSITIONS AND PHARMACEUTICAL FORMS CONTAINING THEM

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Acrylic derivatives of piperazine, the method of preparing same and their application in therapeutics

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Diamino-1 ,3,5-triazines n-substituted with bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators

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Diamino-1,3,5-triazines n-substituted with bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators

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Pyrrolic derivatives, processes for preparing the same and their uses as a drug

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Pyrrolic derivatives, processes for preparing the same and their uses as a drug

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Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors

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1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors

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Sulfoximine substituted 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives and their use as CDK9 kinase inhibitors

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Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists

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Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists

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3-(piperidinyl)- and 3-(pyrrolidinyl)-lh-indazoles, a process for their preparation and their use as a medicament

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Novel derivatives of benzimidazole, methods for their preparing, their using and pharmaceutical composition containing thereof

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Isatin derivatives for use as in vivo imaging agents

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Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists

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Vla-4 antagonists

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Bis-indolic derivatives, their uses in particular as antibacterials

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1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors

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Solid phase synthesis of glutamate-urea-lysine derived (gul derived) prostate-specific membrane antigen (psma) targeting conjugates and their use as precursors for therapeutic and / or diagnostic agents

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Solid phase synthesis of glutamate-urea-lysine derived (gul derived) prostate-specific membrane antigen (psma) targeting conjugates and their use as precursors for therapeutic and / or diagnostic agent

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Nitrogen containing compounds and their use as antibacterial agents

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Carboline-3-carboxylic acid modified related sequences of Ala-Arg-Pro-Ala-Lys, their synthesis and use as thromobolytic agent

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Novel oxazolidinone derivatives and their use as orexin receptor antagonists

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