Ligands of estrogen receptors and , method of their preparation and pharmaceuticals comprising them
Номер патента: EP2274316A1
Опубликовано: 19-01-2011
Автор(ы): David Sedlak, Martin Kotora, Petr Bartunek, Petr Novak
Принадлежит: Institute of Molecular Genetics CAS, Institute of Organic Chemistry and Biochemistry CAS, Prirodovedecka fakulta Univezita Karlova Albertov 6
Опубликовано: 19-01-2011
Автор(ы): David Sedlak, Martin Kotora, Petr Bartunek, Petr Novak
Принадлежит: Institute of Molecular Genetics CAS, Institute of Organic Chemistry and Biochemistry CAS, Prirodovedecka fakulta Univezita Karlova Albertov 6
Реферат: The invention relates to novel ligands of the estrogen receptors α and β of general formula (II), which are useful as active substance of pharmaceuticals, for example pharmaceutical compositions useful for hormone replacement therapy, as well as for the treatment of tumour and inflammatory diseases. The invention relates also to a novel preparation method of these ligands comprising cyclotrimerization of ethynylestradiol with the appropriate diyne in an organic solvent. Further, the invention relates to pharmaceuticals comprising the novel compounds according to the invention.
Ligands of Estrogen Receptors alpha and beta, Method of Their Preparation, and Pharmaceuticals Comprising Them
Номер патента: US20110118225A1. Автор: Petr Novak,Martin Kotora,Petr Bartunek,David Sedlak. Владелец: USTAV UORGANICKE CHEMIE A BIOCHEMIE AV CR VVI. Дата публикации: 2011-05-19.