ESTERS OF FLUORENE-CARBOXYL ACIDS AND PROCEDURES FOR THEIR PREPARATION
Номер патента: PE20031029A1
Опубликовано: 27-01-2004
Автор(ы): Georg Speck, Gerald Pohl, Gerd Morschhauser, Helmut Meissner, Michael P Pieper, Richard Reichl, Sabine Germeyer, Sabine Pestel
Принадлежит: BOEHRINGER INGELHEIM PHARMA
Опубликовано: 27-01-2004
Автор(ы): Georg Speck, Gerald Pohl, Gerd Morschhauser, Helmut Meissner, Michael P Pieper, Richard Reichl, Sabine Germeyer, Sabine Pestel
Принадлежит: BOEHRINGER INGELHEIM PHARMA
Реферат: SE REFIERE A ESTERES DE ACIDOS FLUORENO-CARBOXILICOS DE FORMULA I DONDE A ES UN RADICAL CON DOS ENLACES SELECCIONADO DE GRUPO a, b, c; X- ES UN ANION CON CARGA NEGATIVA; R ES H, OH, METILO, ETILO, ENTRE OTROS; R1 Y R2 SON ALQUILO C1-C5 CON CICLOALQUILO C3-C6, OH, HALO; R1 Y R2 SON UN PUENTE COMUN DE ALQUILENO C3-C5; R3, R4, R3' Y R4' SON H, ALQUILO C1-C4, ALQUILOXI C1-C4, HIDROXI, -CF3, -CHF2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS METOBROMURO DEL ESTER DE TROPENOL CON ACIDO 9-HIDROXI-FLUORENO-9-CARBOXILICO, METOBROMURO DEL ESTER DE TROPENOL CON ACIDO 9-FLUORO-FLUORENO-9-CARBOXILICO, METOBROMURO DEL ESTER DE ESCOPINA CON ACIDO 9-HIDROXI-FLUORENO-9-CARBOXILICO, ENTRE OTROS. SE REFIERE ADEMAS A FORMULACIONES FARMACEUTICAS QUE CONTIENEN UNA SUSTANCIA ADICIONAL SELECCIONADO DE ANTIALERGICOS, ANTAGONISTAS DE LEUCOTRIENOS, CORTICOESTEROIDES REFERS TO ESTERS OF FLUORENE-CARBOXYL ACIDS OF FORMULA I WHERE A IS A RADICAL WITH TWO LINKS SELECTED FROM GROUP a, b, c; X- IS AN ANION WITH NEGATIVE CHARGE; R IS H, OH, METHYL, ETHYL, AMONG OTHERS; R1 AND R2 ARE C1-C5 ALKYL WITH C3-C6 CYCLOALKYL, OH, HALO; R1 AND R2 ARE A COMMON C3-C5 ALKYLENE BRIDGE; R3, R4, R3 'AND R4' ARE H, C1-C4 ALKYL, C1-C4 ALKYLOXY, HYDROXY, -CF3, -CHF2, AMONG OTHERS. PREFERRED COMPOUNDS METOBROMIDE OF TROPENOL ESTER WITH 9-HYDROXY-FLUORENE-9-CARBOXYL ACID, METOBROMIDE OF TROPENOL ESTER WITH 9-FLUORO-FLUORENE-9-CARBOXYL-9-CARBOXYL-ACID-ACID-SPUIDROMIDE-SPORINE-ACID 9-CARBOXYL, AMONG OTHERS. ALSO REFERS TO PHARMACEUTICAL FORMULATIONS CONTAINING AN ADDITIONAL SUBSTANCE SELECTED FROM ANTI-ALLERGICS, LEUKOTRIEN ANTAGONISTS, CORTICOSTEROIDS
Novel fluorene carboxylic acid ester, process for its production and use as a drug
Номер патента: JP4484522B2. Автор: サビーネ ペステル,リヒャルト ライヒル,ヘルムット マイスナー,ゲラルト ポール,ミヒャエル ペー ピーパー,サビーネ ゲルメイヤー,ゲオルク スペック,ゲルト モルシュホイザー. Владелец: ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト. Дата публикации: 2010-06-16.