Piperidine and morpholine derivatives and their use as therapeutic agents
Номер патента: EP0835253A1
Опубликовано: 15-04-1998
Автор(ы): Christopher John Swain, Graeme Irvine Stevenson, Jason Elliott, Raymond Baker
Принадлежит: Merck Sharp and Dohme Ltd
Опубликовано: 15-04-1998
Автор(ы): Christopher John Swain, Graeme Irvine Stevenson, Jason Elliott, Raymond Baker
Принадлежит: Merck Sharp and Dohme Ltd
Реферат: The present invention provides compounds of formula (I), wherein R1 is a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulphur, which group is optionally substituted; R2 is hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy, CF3, OCF3, NO2, CN, SR?a, SORa, SO¿2Ra, CO2R?a, CONRaRb, C¿2-6alkenyl, C2-6alkynyl or C1-4alkyl substitued by C1-4alkoxy, where R?a and Rb¿ each independently represent hydrogen or C¿1-4?alkyl; R?3¿ is hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy substituted by C1-4alkoxy or CF3; R?4, R5, R6, R9a, R9b¿, A, X and Y are as defined in the specification; and m is zero or 1, and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
Imidazopyrimidine derivatives and triazolopyrimidine derivatives their use and preparation process
Номер патента: NZ522241A. Автор: Ming Wang,Scott Miller,Hiroshi Omura,Noriyuki Yamamoto,Timothy B Lowinger,Norihiro Kawamura,Muneto Mogi,Takeshi Yura,Martha E Rodriguez,Gyoonhee Han,Toshio Kokubo,Yingfu Li,Nagahiro Yoshida,Makiko Marumo,Arnel B Concepcion,Hiroko Katsumata,William J Cott,Margaret A Popp,Aniko M Redmann. Владелец: Bayer AG. Дата публикации: 2004-04-30.