Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
Номер патента: NZ583017A
Опубликовано: 24-02-2012
Автор(ы): Haiming Zhang, Hugh Alfred Burgoon Jr, Jie Yan, Qiuling Song, Ramanaiah C Kanamarlapudi, Shinya Iimura, Wenxue Wu
Принадлежит: Lexicon Pharmaceuticals Inc
Опубликовано: 24-02-2012
Автор(ы): Haiming Zhang, Hugh Alfred Burgoon Jr, Jie Yan, Qiuling Song, Ramanaiah C Kanamarlapudi, Shinya Iimura, Wenxue Wu
Принадлежит: Lexicon Pharmaceuticals Inc
Реферат: Disclosed are methods of preparing trifluoro-phenylethoxy compounds, represented by general formula II(a), by contacting a compound of general formula (IV) with a platinum group metal catalyst having a chiral ligand. Examples of the compounds of general formula (IV) include 1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl-2,2,2-trifluoroethanone and 1-(2-bromo-5-chlorophenyl)-3-methyl-1H-pyrazole.
Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
Номер патента: EP2187887B1. Автор: Jie Yan,Shinya Iimura,Qiuling Song,Wenxue Wu,Haiming Zhang,Ramanaiah C. Kanamarlapudi,Mark S. Bednarz,Hugh Alfred Burgoon, Jr.. Владелец: Lexicon Pharmaceuticals Inc. Дата публикации: 2017-11-15.