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Compounds to treat Alzheimer's disease

Номер патента: NZ538542A
Опубликовано: 29-09-2006
Автор(ы): Andrea Gailunas, Barbara Jagodzinska, James P Beck, John N Freskos, Lawrence Y Fang, Michael Maillard, Roy Hom, Ruth E Tenbrink, Shon R Pulley, VARGHESE John
Принадлежит: Elan Pharm Inc

Реферат: Disclosed are protected compounds of formula (III) and (IV) wherein: R1 is -(CH2)-phenyl optionally substituted by one, two, three or four substituents as defined; R2 and R3 are hydrogen; X1 is -Cl, -Br, -I, or -OSO2Rx, where Rx is 4-methylphenyl-, 3-nitrophenyl, or CH3-; and The protecting group is as defined. Compounds of the type disclosed are useful as intermediates in the manufacture of a medicament for treating Alzheimer's disease, in particular for inhibiting beta-secretase-mediated cleavage of amyloid precursor protein (APP).

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Methods and kits for the differential diagnosis of Alzheimer's disease versus frontotemporal dementia and for the diagnosis of frontotemporal dementia, comprising FAS-L and CK 18 as biomarkers

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Methods for diagnosis and prognosis of alzheimer's disease

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Diagnostic assay for alzheimer's disease

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Methods of determining levels of free amino acids and dipeptides and diagnosing alzheimer's diseases

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Diagnostic biomarker profiles for the detection and diagnosis of alzheimer's disease

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Method of diagnosing alzheimer's disease

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Stratification by sex and apoe genotype identifies metabolic heterogeneity in alzheimer's disease

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Multi-modality neural network for alzheimer's disease classification

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Companion diagnostic for nsaids and donepezil for treating specific subpopulations of patients suffering from alzheimer's disease

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Companion diagnostic for nsaids and donepezil for treating specific subpopulations of patients suffering from alzheimer's disease

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Companion diagnostic for nsaids and donepezil for treating specific subpopulations of patients suffering from alzheimer's disease

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METHOD FOR DETECTION OF PrP-INTERACTING Aβ OLIGOMERIC SPECIES IN BIOLOGICAL MATERIALS AS A DIAGNOSIS OF ALZHEIMER'S DISEASE

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Cell-Based Biosensor for Early Alzheimer's Disease Detection

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Biomarkers for alzheimer's disease

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Mass spectrometry analysis of markers for alzheimer's disease

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Multi-modality neural network for alzheimer's disease classification background

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Diagnostic method for alzheimer's disease based on holo-transcobalamin II

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Diagnostic method for alzheimer's disease based on holo-transcobalamin ii

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Diagnostic method for alzheimer's disease based on holo-transcobalamin ii

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Compositions, kits, and methods for detecting preclinical alzheimer's disease

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G PROTEIN-COUPLED RECEPTOR ANTAGONIST AND ITS USE FOR PREVENTING AND TREATING ALZHEIMER'S DISEASE

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Medication for treating alzheimer's disease and method of treating alzheimer's disease

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Compositions and methods for treating alzheimer's disease

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N'-(2-Chloro-6-Methylbenzoyl)-4-Methyl-3[2-(3-Quinolyl) Ethynyl]-Benzohydrazide for treatment of Alzheimer's disease.

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Therapy of alzheimer's disease with using amyloid-beta peptide antibodies, and mixtures thereof

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METHODS FOR ASSESSING RISK OF ALZHEIMER'S DISEASE IN A PATIENT

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Method for differential diagnosis of alzheimer's disease, vascular and mixed dementia

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Peptide with protective action against alzheimer's disease

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Protein markers for mild cognitive impairment and alzheimer's disease

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Biomarkers of mild cognitive impairment and Alzheimer's disease

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Aspartic proteases, termed aspartyl protease 1 and 2 (ASP1 and ASP2) and gene variants thereof and their role in Alzheimer's disease

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Method for diagnosis of alzheimer's disease

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