Indole amide derivatives and their use as glycogen phosphorylase inhibitors
Номер патента: EP1485371A2
Опубликовано: 15-12-2004
Автор(ы): Alan Martin AstraZeneca R & D Alderley BIRCH, Andrew David AstraZeneca R & D Alderley MORLEY
Принадлежит: AstraZeneca AB
Опубликовано: 15-12-2004
Автор(ы): Alan Martin AstraZeneca R & D Alderley BIRCH, Andrew David AstraZeneca R & D Alderley MORLEY
Принадлежит: AstraZeneca AB
Реферат: Heterocyclic amides of formula (1) wherein: is a single or double bond; A is phenylene or heteroarylene; m is 0, 1 or 2;n is 0, 1 or 2;R1 is selected from for example halo, nitro, cyano, hydroxy, carboxy; R2 is hydrogen, hydroxy or carboxy;R3 is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C 1-4 alkyl(optionally substituted by 1 or 2 R8 groups);R4 is independently selected from for example hydrogen, halo, nitro, cyano, hydroxy, C 1-4 alkyl, and C 1-4 alkanoyl; R8 is selected from for example hydroxy, -COCOOR9, -C(O)N(R9)(R10), -NHC(O)R9 , (R9)(R10)N- and -COOR9;R9 and R10 are selected from for example hydrogen, hydroxy, C 1-4 alkyl (optionally substituted by 1 or 2 R13 );R13 is selected from hydroxy, halo, trihalomethyl and C 1-4 alkoxy;or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
Novel derivatives and their use as selective inhibitors of caspase-2
Номер патента: EP3433243A1. Автор: Etienne Jacotot. Владелец: Universite Paris Diderot Paris 7. Дата публикации: 2019-01-30.