Methods for reducing rna immunogenicity and rna molecules with decreased immunogenicity
Номер патента: ZA202211633B
Опубликовано: 28-02-2024
Автор(ы): Henrik Baron Van Asbeck Alexander, Wilhelmus Carolus Dieker Jürgen
Принадлежит: Ribopro B V
Опубликовано: 28-02-2024
Автор(ы): Henrik Baron Van Asbeck Alexander, Wilhelmus Carolus Dieker Jürgen
Принадлежит: Ribopro B V
Реферат: The present invention relates to a method for decreasing the immunogenicity of an RNA molecule and/or at least maintaining the translation efficacy thereof. The present invention further relates to an RNA molecule, which is modified as compared to a corresponding wildtype RNA molecule, wherein the exchange of codons results in the total cytidine content of the modified RNA molecule being at least 10% less than the total cytidine content of the corresponding RNA molecule transcribed from said wildtype DNA sequence. The present invention also relates to an RNA molecule, wherein the exchange of codons results in the total uridine content of the modified RNA molecule being at least 10% less than the total uridine content of the corresponding RNA molecule transcribed from said wild-type DNA sequence. Finally, the present invention relates to the use of an RNA molecule of this invention in genome editing.
Methods for reducing rna immunogenicity and rna molecules with decreased immunogenicity
Номер патента: CA3177317A1. Автор: Alexander Henrik BARON VAN ASBECK,Jürgen Wilhelmus Carolus DIEKER. Владелец: Individual. Дата публикации: 2021-11-04.