Crystalline salts of methyl 2- ( (r) - ( 3-chloro phenyl) ( (r) -l- ( (s) -2- (methylamino) -3- ( (r) -tetrahydro-2h-pyran-3-yl) propylcarbamoyl )
Номер патента: EP2462137A1
Опубликовано: 13-06-2012
Автор(ы): David A. Claremon, Lanqi Jia, Robert D. Simpson
Принадлежит: Vitae Pharmaceuticals LLC
Опубликовано: 13-06-2012
Автор(ы): David A. Claremon, Lanqi Jia, Robert D. Simpson
Принадлежит: Vitae Pharmaceuticals LLC
Реферат: Mucic acid salts of a compound represented by the following structural formula:(I) are disclosed. In particular, single crystalline mucic acid salts of the compound represented by structural formula (I) are characterized by a variety of properties and physical measurements. Methods of producing the mucic acid salts, using the salts to antagonize one or more aspartic proteases, and methods of treating a number of aspartic protease mediated disorders using the salts are described herein.
New process for the preparation of 1- [5- (3-chloro-phenyl) - isooxazol-3-yl]-ethanone and (r) -1- [5- (3-chloro-phenyl) - isooxazol-3-yl]-ethanol
Номер патента: EP2379514A4. Автор: Elfyn Jones,Hans Aastroem. Владелец: AstraZeneca AB. Дата публикации: 2012-06-13.