Cyclic peptide antibiotics
Номер патента: EP3681875A1
Опубликовано: 22-07-2020
Автор(ы): Emily J. HANAN, Georgette Castanedo, Guosheng Wu, Keira GARLAND, Marie Gabrielle BRAUN, Paul Gibbons, Peter Andrew Smith, Po-Wai Yuen, Richard Pastor, Yuhong FU, Yunxing Cheng
Принадлежит: F Hoffmann La Roche AG
Опубликовано: 22-07-2020
Автор(ы): Emily J. HANAN, Georgette Castanedo, Guosheng Wu, Keira GARLAND, Marie Gabrielle BRAUN, Paul Gibbons, Peter Andrew Smith, Po-Wai Yuen, Richard Pastor, Yuhong FU, Yunxing Cheng
Принадлежит: F Hoffmann La Roche AG
Реферат: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Cyclic peptide antibiotics
Номер патента: WO2019052545A1. Автор: Peter Andrew Smith,Po-Wai Yuen,Richard Pastor,Georgette Castanedo,Guosheng Wu,Paul Gibbons,Yuhong FU,Keira GARLAND,Emily J. HANAN,Yunxing Cheng,Marie Gabrielle BRAUN. Владелец: F. Hoffmann-La Roche AG. Дата публикации: 2019-03-21.