Co-inhibition of cd47/sirp? binding and nedd8-activating enzyme e1 regulatory subunit for the treatment of cancer
Номер патента: EP4323406A1
Опубликовано: 21-02-2024
Автор(ы): Hikmat H. Assi, Mark P. Chao
Принадлежит: Gilead Sciences Inc
Опубликовано: 21-02-2024
Автор(ы): Hikmat H. Assi, Mark P. Chao
Принадлежит: Gilead Sciences Inc
Реферат: Provided are methods for treating, mitigating, or preventing or delaying the recurrence or metastasis of, a cancer in a subject comprising co-administering: (a) an agent that inhibits binding between CD47 and SIRPα; and (b) a NEDD8-activating enzyme E1 regulatory subunit (NAE1) inhibitor. Further provided are kits for practicing such methods.
Co-inhibition of cd47/sirp.alpha. binding and nedd8-activating enzyme e1 regulatory subunit for the treatment of cancer
Номер патента: CA3215977A1. Автор: Mark P. Chao,Hikmat H. Assi. Владелец: Gilead Sciences Inc. Дата публикации: 2022-10-20.