2-aryl-3-aroylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome
Номер патента: NZ503990A
Опубликовано: 31-05-2002
Автор(ы): George Joseph Cullinan
Принадлежит: Lilly Co Eli
Опубликовано: 31-05-2002
Автор(ы): George Joseph Cullinan
Принадлежит: Lilly Co Eli
Реферат: The compound of formula I, optionally in combination with the compound of formula II, is useful for inhibiting estrogen deprivation syndrome. In formula I: R and R1 are independently hydrogen, hydroxy, C1-C6 alkoxy, OCH2Ar, OCO(C1-C6 alkyl), OCOAr, Ar is phenyl or substituted phenyl, R2 is chlorine, bromine, OCH2Ar, OCO (C1-C6 alkyl), OCOAr. In formula II: R3 and R4 are independently hydrogen, C1-C6 alkyl, (C1-C6 alkyl) or COAr, R5 is pyrolidin-1-yl, piperidin-1-yl or hexamethleneimin-1-yl, where the nitrogen of the R5 is optionally the N-oxide Or a pharmaceutical salt or solvate thereof.
2-aryl-3-aroylbenzo[b]thiophenes useful for the treatment of a estrogen deprivation syndrome
Номер патента: IL135509A0. Автор: . Владелец: Lilly Co Eli. Дата публикации: 2001-05-20.