Oligonucleotide for inhibiting quaking activity
Номер патента: EP4370677A1
Опубликовано: 22-05-2024
Автор(ы): Anton Jan Van Zonneveld, Eric Peter Van Der Veer, Falk WACHOWIUS, Gerardus Theodorus Marie WAGENAAR, Jurrien Prins, Ruben Gosewinus DE BRUIN
Принадлежит: Leids Universitair Medisch Centrum LUMC
Опубликовано: 22-05-2024
Автор(ы): Anton Jan Van Zonneveld, Eric Peter Van Der Veer, Falk WACHOWIUS, Gerardus Theodorus Marie WAGENAAR, Jurrien Prins, Ruben Gosewinus DE BRUIN
Принадлежит: Leids Universitair Medisch Centrum LUMC
Реферат: The invention relates to the field of oligonucleotides that can inhibit a RNA-binding protein (RBP) such as Quaking (QKI) by acting as a binding sequence for said RBP ("decoys"). Such oligonucleotide may be used for the treatment of any disease or condition associated with an elevated expression level of QKI, such as inflammation or fibrosis.
Oligonucleotides for pms1 modulation
Номер патента: WO2023215390A3. Автор: Anastasia Khvorova,Daniel O'reilly,Chantal FERGUSON,Jillian Belgrad. Владелец: University of Massachusetts. Дата публикации: 2024-02-01.