Novel therapeutically active compounds of the formula
Номер патента: GB2153354B
Опубликовано: 21-10-1987
Автор(ы): Hans Eric Peter Strom, Karl Stefan Bengtsson, Lars George Johansson, Marianne Elisabet Widman, Paulis Tomas De, Sven Ove Ogren, Thomas Högberg
Принадлежит: Astra Lakemedel AB
Опубликовано: 21-10-1987
Автор(ы): Hans Eric Peter Strom, Karl Stefan Bengtsson, Lars George Johansson, Marianne Elisabet Widman, Paulis Tomas De, Sven Ove Ogren, Thomas Högberg
Принадлежит: Astra Lakemedel AB
Реферат: Novel therapeutically active compounds of the formula <CHEM> wherein Z , being Z<1>, Z<2> or Z<3>, is the same or different and selected among OH, OR<1>, NH2, NR2<4>, NHR<4>, SH, SR<4> and OR<4> wherein R<1> is a formyl group, an acyl group, an alkoxycarbonyl group or a mono- or dialkylcarbamoyl group and R<4> is a lower alkyl group, R<2> is a hydrogen, a halogen, a lower alkyl or a lower trifluoroalkyl group, R<3> is a hydrogen atom, a lower alkyl group, an alkenyl group, an alkynyl group or a phenyl group, which phenyl group could optionally be substituted by one or more of fluoro, chloro, bromo, trifluoromethyl, methyl, ethyl, methoxy or ethoxy in the ortho, metal or para positions, or optionally substituted by methylenedioxy, provided that at least one of Z<1>, Z<2> and Z<3> is a group OR<4> and further provided that when Z<2> is OH or NH2, Z<1> is NR2<4>, NHR<4>, SH, SR<4> or OR<4> or a physiologically acceptable salt or optical isomer thereof, intermediates and methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.
Substituted 1-naphthylpyrazole-3-carboxamides, method of their synthesis, pharmaceutical composition containing thereof and intermediate compounds of synthesis
Номер патента: RU2140912C1. Автор: Молимар Жан-Шарль,Лабеэв Бернар,Гюли Даниелл,Жанжан Франсис,Буажгрэн Робер. Владелец: Санофи. Дата публикации: 1999-11-10.