Myeloid-specific promoter and use thereof
Номер патента: EP4330398A1
Опубликовано: 06-03-2024
Автор(ы): Haokun Yuan, Lung-Ji Chang, Rui Zhang
Принадлежит: Beijing Meikang Geno Immune Biotechnology Co Ltd
Опубликовано: 06-03-2024
Автор(ы): Haokun Yuan, Lung-Ji Chang, Rui Zhang
Принадлежит: Beijing Meikang Geno Immune Biotechnology Co Ltd
Реферат: Provided are a myeloid-specific promoter and a use thereof. The myeloid-specific promoter includes a nucleic acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 2. The myeloid-specific promoter shows specificity to myeloid tissues. It initiates a gene expression with high efficiency in myeloid cells, but with relative low efficiency in non-myeloid cells. As such, the myeloid-specific promoter regulates the specific expression of a gene in myeloid tissues. The myeloid-specific promoter and the CYBB gene are inserted into a lentiviral vector, and the constructed lentiviral expression vector shows specificity to myeloid tissues and can effectively restore the expression of gp91-phox protein and restore the generation function of ROS, which is of great significance for CGD treatment.
Myeloid-specific promoter and use thereof
Номер патента: US20240209395A1. Автор: Rui Zhang,Lung-Ji Chang,Haokun Yuan. Владелец: Beijing Meikang Geno-Immune Biotechnology Co Ltd. Дата публикации: 2024-06-27.