Modulation of bio-electrical rhythms via a novel engineering approach
Номер патента: EP1796472A2
Опубликовано: 20-06-2007
Автор(ы): Eduardo Marbán, Heecheol Cho, Ronald A. Li, Suk-Ying Tsang, TIAN Xue
Принадлежит: JOHNS HOPKINS UNIVERSITY
Опубликовано: 20-06-2007
Автор(ы): Eduardo Marbán, Heecheol Cho, Ronald A. Li, Suk-Ying Tsang, TIAN Xue
Принадлежит: JOHNS HOPKINS UNIVERSITY
Реферат: The present invention relates to novel compositions and methods to induce , and/or' modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).
Modulation of bio-electrical rhythms via a novel engineering approach
Номер патента: US09480719B2. Автор: TIAN Xue,Eduardo Marbán,Ronald A. Li,Suk-Ying Tsang,Heecheol Cho. Владелец: JOHNS HOPKINS UNIVERSITY. Дата публикации: 2016-11-01.