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  • Antibodies specific for hyperphosphorylated tau and methods of use thereof

Antibodies specific for hyperphosphorylated tau and methods of use thereof

Номер патента: MY197836A
Опубликовано: 20-07-2023
Автор(ы): Ayodeji Abdur-Rasheed Asuni, Christiane VOLBRACHT, Jan Torleif Pedersen, Juhl Karsten, Justus Claus Alfred DAECHSEL, Kristian Kj?Rgaard, Lars ?Stergaard Pedersen, LAURENT David, Lena Tagmose, Lone HELBO, Marigo Mauro, Nina Helen ROSENQVIST, S?Ren Christensen, Thomas Jensen
Принадлежит: H Lundbeck AS

Реферат: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer?s disease and other tauopathies.

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