Tyrosine kinase containing Ig and EGF homology domains (TIE) ligands and nucleic acid molecules encoding them
Опубликовано: 30-11-2001
Автор(ы): Audrey Goddard, Austin L Gurney, Daniel Tumas, David Botstein, Kenneth J Hillan, Margaret Roy, Napoleone Ferrara, Paul J Godowski, Ralph Schwall
Принадлежит: Genentech Inc
Реферат: Isolated nucleic acid molecules encoding the TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules. Wherein; Seq ID 2 (NL1): MRPLCVTCWWLGLLAAMGAVAGQEDGFEGTEEGSPREFIYLNRYKR AGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELL NNELLKQKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYM QLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLEHKYQHL ATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIIN QISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQAL EDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSV NFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWS GRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDR DHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGV YWAEFRGGSYSLKKVVMMIRPNPNTFH Seq ID 4 (NL5): MKTFTWTLGVLFFLLVDTGHCRGGQFKIKKINQRRYPRATDGKEEAKKC AYTFLVPEQRITGPICVNTKGQDASTIKDMITRMDLENLKDVLSRQKREID VLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDN SLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITL LEEQCLRIFSRQDTHVSPPLVQVVPQHIPNSQQYTPGLLGGNEI QRDPGYPRDLMPPPDLATSPTKSPFKIPPVTFINEGPFK DCQQAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSV NFFRNWENYKKGFGNIDGEYWLGLENIYMLSNQDNYKLLIELEDW SDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNG KQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGH YRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID Seq ID 6 (NL8): MGKPWLRALQLLLLLGASWARAGAPRCTYTFVLPPQKFTGAVC WSGPASTRATPEAANASELAALRMRVGRHEELLRELQRLAAADGA VAGEVRALRKESRGLSARLGQLRAQLQHEAGPGAGPGA DLGAEPAAALALLGERVLNASAEAQRAAARFHQLDVKFRELAQLV TQQSSLIARLERLCPGGAGGQQQVLPPPPLVPVVPVRLVGST SDTSRMLDPAPEPQRDQTQRQQEPMASPMPAGHPAVPTKPVGPWQDCAEA RQAGHEQSGVYELRVGRHVVSVWCEQQLEGGGWTVIQRRQDGSVN FFTTWQHYKAGFGRPDGEYWLGLEPVYQLTSRGDHELLVLLEDWGGR GARAHYDGFSLEPESDHYRLRLGQYHGDAGDSLSWHNDKPFS TVDRDRDSYSGNCALYQRGGWWYHACAHSNLNGVWHHGGH YRSRYQDGVYWAEFRGGAYSLRKAAMLIRPLKL Seq ID 19 (NL4): MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCC EEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSK RMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLY QKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLV SFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEME DWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFST KDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNK HLDGITWYGWHGSTYSLKRVEMKIRPEDFKP
Tie ligand homologues
Номер патента: EP1015585A2. Автор: Ralph Schwall,Napoleone Ferrara,David Botstein,Audrey Goddard,Paul J. Godowski,Austin L. Gurney,Daniel Tumas,Kenneth Hillan,Margaret Roy. Владелец: Genentech Inc. Дата публикации: 2000-07-05.