Transgenic rodents and rodent cell lines expressing hiv co-receptors
Номер патента: EP1141360A1
Опубликовано: 10-10-2001
Автор(ы): Mark A. Goldsmith, Oliver Keppler, Robert E. Atchison, Roberto F. Speck
Принадлежит: J David Gladstone Institutes
Опубликовано: 10-10-2001
Автор(ы): Mark A. Goldsmith, Oliver Keppler, Robert E. Atchison, Roberto F. Speck
Принадлежит: J David Gladstone Institutes
Реферат: The present invention features transgenic rodent models of HIV, wherein the transgenic rodent or transgenic rodent cell has incorporated into its genome genes encoding a human CD4 receptor and a human chemokine receptor. In particular the invention relates to transgenic rats, or mice characterized by being susceptible to infection with HIV, capable of expressing HIV structural genes, or HIV replication. The transgenic rodent or rodent cell of this invention is useful for studying the molecular basis of HIV infection, replication and pathogenicity, as well as for the testing of agents for new antiviral or vaccine strategies.
Transgenic rats and rat cell lines expressing human CD4 and a human chemokine receptor
Номер патента: US6372956B1. Автор: Mark A. Goldsmith,Roberto F. Speck,Robert E. Atchison,Oliver Keppler. Владелец: J David Gladstone Institutes. Дата публикации: 2002-04-16.